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55. Index

Author

De Luca, Tom and Buell, John

Published
2005

60. Notes

Author

De Luca, Tom and Buell, John

Published
2005

65. Le Indicazioni al by - pass aorto-coronarico negli anni 1970-1980

Author

NAPPI, Gianantonio, A. Iacono, F. De Vivo, L. Piazza, N. Mininni, U. F. Civitello, A. Scialdone, C. Vosa, L. De Luca T. S., M. Cotrufo, Nappi, Gianantonio, A., Iacono, F., De Vivo, L., Piazza, N., Mininni, U. F., Civitello, A., Scialdone, C., Vosa, L. De Luca T., S., and M., Cotrufo

Published
1983

66. L'emergenza nelle cardiopatie congenite cianogene

Author

C. VOSA, D. CASALE, L. DE LUCA T. S, G. CAIANIELLO, V. ESPOSITO, NAPPI, Gianantonio, C., Vosa, D., Casale, L. DE LUCA T., S., G., Caianiello, V., Esposito, and Nappi, Gianantonio

Published
1983

73. I tumori del cuore destro: esperienza di tre casi

Author

C. VOSA, L. DE LUCA T. S, L. PIAZZA, F. DE VIVO, B. GIANNOLO, F. MADONNA, AGOZZINO, Lucio, NAPPI, Gianantonio, C., Vosa, L. DE LUCA T., S., L., Piazza, F., DE VIVO, B., Giannolo, F., Madonna, Agozzino, Lucio, and Nappi, Gianantonio

Published
1983

80. I tumori del cuore destro: esperienza di tre casi

Author

NAPPI, Gianantonio, C. Vosa, L. De Luca T. S., L. Piazza, F. De Vivo, B. Giannolo, F. Madonna, AGOZZINO, Lucio, M. Cotrufo, Nappi, Gianantonio, C., Vosa, L. De Luca T., S., L., Piazza, F., De Vivo, B., Giannolo, F., Madonna, Agozzino, Lucio, and M., Cotrufo

Published
1983

82. Treatment of infected aorto-bifemoral dacron graft

Author

NAPPI, Gianantonio, M. Cotrufo, B. Crescenzi, L. Piazza, F. De Vivo, G. Caianiello, L. De Luca T. S., C. Vosa, Nappi, Gianantonio, M., Cotrufo, B., Crescenzi, L., Piazza, F., De Vivo, G., Caianiello, L. De Luca T., S., and C., Vosa

Published
1982

85. Planetary Cinema

Author

de Luca, Tiago

Subjects
Earth, World, Global consciousness, Cinema, Media archaeology, bic Book Industry Communication::A The arts::AF Art forms::AFK Non-graphic art forms::AFKV Electronic, holographic & video art, bic Book Industry Communication::R Earth sciences, geography, environment, planning::RB Earth sciences, bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFD Media studies
Abstract

The story is now familiar. In the late 1960s humanity finally saw photographic evidence of the Earth in space for the first time. According to this narrative, the impact of such images in the consolidation of a planetary consciousness is yet to be matched. This book tells a different story. It argues that this narrative has failed to account for the vertiginous global imagination underpinning the media and film culture of the late nineteenth century and beyond. Panoramas, giant globes, world exhibitions, photography and stereography: all promoted and hinged on the idea of a world made whole and newly visible. When it emerged, cinema did not simply contribute to this effervescent globalism so much as become its most significant and enduring manifestation. Planetary Cinema proposes that an exploration of that media culture can help us understand contemporary planetary imaginaries in times of environmental collapse. Engaging with a variety of media, genres and texts, the book sits at the intersection of film/media history and theory/philosophy, and it claims that we need this combined approach and expansive textual focus in order to understand the way we see the world.

Published
2022
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92. [Long-term tonometry control of laser therapy of open-angle glaucoma]

Author

Malagola, Romualdo, Motolese, E. D., and De Luca, T.

Subjects
Adult, Aged, 80 and over, Male, tonometric follow-up, glaucoma, laser trabeculoplasty, Trabeculectomy, Middle Aged, Tonometry, Ocular, Postoperative Complications, Humans, Female, Laser Therapy, Glaucoma, Open-Angle, Intraocular Pressure, Aged, Follow-Up Studies
Published
1988

93. Bone marrow transplantation in Hunter syndrome (mucopolysaccharidosis type II): two-year follow-up of the first Italian patient and review of the literature

Author

Gv, Coppa, Gabrielli O, Zampini L, Pierani P, Pl, Giorgi, Am, Jezequel, Orlandi F, Miniero R, Alessandro Busca, and De Luca T

Subjects
Male, Italy, Liver, Child, Preschool, Biopsy, Needle, Humans, Bone Marrow Transplantation, Follow-Up Studies, Glycosaminoglycans, Mucopolysaccharidosis II
Abstract

A patient with Hunter syndrome, or mucopolysaccharidosis type II (MPS-osis II), was subjected to bone marrow transplantation (BMT), at the age of 2 9/12 years. A two-year follow-up ensued to the purpose of comparing clinical, biochemical, neuropsychologic status pre- and post-BMT. From the clinical standpoint, a complete normalization of hepatosplenomegaly was observed. In addition the skin decreased in thickness and joint mobility improved. The echocardiography showed normalization of left ventricle size. With the exception of verbal capabilities, there was no further deterioration of the neuropsychologic profile. The ultrastructural examination of the liver showed an almost total disappearance of storage material. Normal iduronate sulfatase levels in leukocytes and lymphoblasts were constantly found after BMT. A qualitative and quantitative improvement in urinary glycosaminoglycan (GAG) excretion was also found. The effectiveness of the BMT in our patient is also assessed in the context of the few cases of MPS-osis II that have been reported to date. A final evaluation of the efficacy of BMT in MPS-osis II will be possible only when a higher number of patients, diagnosed as early as possible and transplanted within the first months of life, can be followed-up for more extended periods of time.

96. Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation

Author

Clemens Zwergel, Marco Tripodi, Donatella Del Bufalo, Annalisa Romanelli, Daniela Trisciuoglio, Cecilia Battistelli, Lucia Altucci, Giulia Stazi, Paola B. Arimondo, Rossella Fioravanti, Teresa De Luca, Alexandra Paulo, Dany Pechalrieu, Sergio Valente, Raffaele Strippoli, Angela Nebbioso, Federica Sarno, Eduarda Mendes, Antonello Mai, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Università degli studi della Campania 'Luigi Vanvitelli' = University of the Study of Campania Luigi Vanvitelli, Universidade de Lisboa = University of Lisbon (ULISBOA), Istituto Nazionale di Malattie Infettive 'Lazzaro Spallanzani' (INMI), Department of Molecular Medicine, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Pharmacochimie de la Régulation Epigénétique du Cancer (ETaC), PIERRE FABRE-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie biologique épigénétique - Epigenetic Chemical Biology (EpiCBio), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), IFO - Istituto Nazionale Tumori Regina Elena [Roma] (IRE), CNR Istituto di Biologia e Patologia Molecolari [Roma] (CNR | IBPM), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), This work was supported by PRIN 2016 (prot. 20152TE5PK) (L.A., A.M.), Ricerca Finalizzata 2013 PE-2013-02355271 (A.M.), the Italian Association for Cancer Research AIRC-19162 (A.M.), AIRC-17217 (L.A.) and AIRC-18560 (D.D.B.), NIH (n. R01GM114306) (A.M.), VALERE: Vanvitelli per la Ricerca Program (L.A.), FP7-BLUEPRINT (282510) (L.A., A.M.), the Campania Regional Government Lotta alle Patologie Oncologiche (L.A.), iCURE (CUP B21c17000030007) (L.A.), Campania Regional Government FASE 2: IDEAL (CUP B63D18000560007) (L.A.), PlanCancer2014 (P.B.A.) and FCT, Portugal through UID/DTP/04138/2019 (A.P., E.M.) funds., Zwergel, C., Fioravanti, R., Stazi, G., Sarno, F., Battistelli, C., Romanelli, A., Nebbioso, A., Mendes, E., Paulo, A., Strippoli, R., Tripodi, M., Pechalrieu, D., Arimondo, P. B., De Luca, T., Del Bufalo, D., Trisciuoglio, D., Altucci, L., Valente, S., Mai, A., Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Università degli studi della Campania 'Luigi Vanvitelli', Universidade de Lisboa (ULISBOA), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institute of Molecular Pathology and Biology [Rome] (IPBM), and Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Consiglio Nazionale delle Ricerche (CNR)

Subjects
0301 basic medicine, Cancer Research, Methyltransferase, [SDV]Life Sciences [q-bio], Azacitidine, Decitabine, DNA methyltransferase, Apoptosis, Medicinal chemistry, Protein degradation, lcsh:RC254-282, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, [CHIM]Chemical Sciences, Chemistry, Drug discovery, Apoptosi, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Enzyme inhibition, 030104 developmental biology, Oncology, Cell culture, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, DNMT1, medicine.drug
Abstract

DNA methyltransferases (DNMTs) play a relevant role in epigenetic control of cancer cell survival and proliferation. Since only two DNMT inhibitors (azacitidine and decitabine) have been approved to date for the treatment of hematological malignancies, the development of novel potent and specific inhibitors is urgent. Here we describe the design, synthesis, and biological evaluation of a new series of compounds acting at the same time as DNMTs (mainly DNMT3A) inhibitors and degraders. Tested against leukemic and solid cancer cell lines, 2a&ndash, c and 4a&ndash, c (the last only for leukemias) displayed up to submicromolar antiproliferative activities. In HCT116 cells, such compounds induced EGFP gene expression in a promoter demethylation assay, confirming their demethylating activity in cells. In the same cell line, 2b and 4c chosen as representative samples induced DNMT1 and -3A protein degradation, suggesting for these compounds a double mechanism of DNMT3A inhibition and DNMT protein degradation.

Published
2020
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97. PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

Author

Donatella Del Bufalo, Isabella Sperduti, Italia Falcone, Michele Milella, Giovanni Blandino, Anais Del Curatolo, Ruggero De Maria, Vincenzo Corbo, Michele Simbolo, Teresa De Luca, Matilde Todaro, Andrea Sacconi, Giorgio Stassi, Marina Konopleva, Ludovica Ciuffreda, Ursula Cesta Incani, Aldo Scarpa, Antonina Benfante, Silvia Matteoni, Fabiana Conciatori, Federico Malusa, Adriana Eramo, Chiara Bazzichetto, Francesco Cognetti, Giovanni Sette, James A. McCubrey, Michael Andreeff, Milella, M., Falcone, I., Conciatori, F., Matteoni, S., Sacconi, A., De Luca, T., Bazzichetto, C., Corbo, V., Simbolo, M., Sperduti, I., Benfante, A., Del Curatolo, A., Cesta Incani, U., Malusa, F., Eramo, A., Sette, G., Scarpa, A., Konopleva, M., Andreeff, M., Mccubrey, J., Blandino, G., Todaro, M., Stassi, G., De Maria, R., Cognetti, F., Del Bufalo, D., and Ciuffreda, L.

Subjects
0301 basic medicine, MAPK/ERK pathway, PTEN, RNA interference, protein Kinase inhibitors, RNA, Small Interfering, humans, Phosphoinositide-3 Kinase Inhibitors, Animals, cell line, tumor, drug synergism, everolimus, female, Janus Kinase 1, MAP Kinase Kinase Kinases, mice, neoplastic stem cells, PTEN phosphohydrolase, phosphatidylinositol 3-Kinases, proto-oncogene Proteins c-akt, Pyridones, Pyrimidinones, RNA Interference, STAT3 Transcription Factor, TOR Serine-Threonine Kinases, Multidisciplinary, MAPK/PI3K pathway inhibition, oncology, MAPK/PI3K pathway inhibition, cell line, MAPK/PI3K, inhibition, oncology. inhibition. PTEN, gene, mRNA, cancer cell lines, MEK/mTOR, oncology, mTOR, tumor, Mice, Nude, Biology, Small Interfering, Article, 03 medical and health sciences, Mediator, Settore MED/04 - PATOLOGIA GENERALE, Cell Line, Tumor, medicine, PI3K/AKT/mTOR pathway, Settore MED/06 - ONCOLOGIA MEDICA, RPTOR, Cancer, medicine.disease, Blockade, 030104 developmental biology, Cancer research, biology.protein, RNA
Abstract

Combined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy in oncology. Since PTEN lies at the intersection of these two pathways, we investigated whether PTEN status determines the functional response to combined pathway inhibition. PTEN (gene, mRNA, and protein) status was extensively characterized in a panel of cancer cell lines and combined MEK/mTOR inhibition displayed highly synergistic pharmacologic interactions almost exclusively in PTEN-loss models. Genetic manipulation of PTEN status confirmed a mechanistic role for PTEN in determining the functional outcome of combined pathway blockade. Proteomic analysis showed greater phosphoproteomic profile modification(s) in response to combined MEK/mTOR inhibition in PTEN-loss contexts and identified JAK1/STAT3 activation as a potential mediator of synergistic interactions. Overall, our results show that PTEN-loss is a crucial determinant of synergistic interactions between MAPK and PI3K pathway inhibitors, potentially exploitable for the selection of cancer patients at the highest chance of benefit from combined therapeutic strategies.

Published
2017

98. 1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells

Author

Marco Miceli, Antonello Mai, Gerald Brosch, Alessia Lenoci, Donatella Del Bufalo, Angela Nebbioso, Lucia Altucci, Giulio Dondio, Daniela Trisciuoglio, Sergio Valente, Teresa De Luca, Donatella Labella, Chiara Bigogno, Valente, S, Trisciuoglio, D, De Luca, T, Nebbioso, Angela, Labella, D, Lenoci, A, Bigogno, C, Dondio, G, Miceli, M, Brosch, G, Del Bufalo, D, Altucci, Lucia, and Mai, A.

Subjects
Cellular differentiation, Antineoplastic Agents, HL-60 Cells, Structure-Activity Relationship, hemic and lymphatic diseases, Drug Discovery, medicine, Tumor Cells, Cultured, cancer, Humans, hDAC inhibitors, Cell Proliferation, Oxadiazoles, U937 cell, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Myeloid leukemia, medicine.disease, HCT116 Cells, HDAC1, Histone Deacetylase Inhibitors, Leukemia, Cell culture, Doxorubicin, Cancer cell, Cancer research, Molecular Medicine, Histone deacetylase, Drug Screening Assays, Antitumor, epigenetic
Abstract

We describe 1,3,4-oxadiazole-containing hydroxamates (2) and 2-aminoanilides (3) as histone deacetylase inhibitors. Among them, 2t, 2x, and 3i were the most potent and selective against HDAC1. In U937 leukemia cells, 2t was more potent than SAHA in inducing apoptosis, and 3i displayed cell differentiation with a potency similar to MS-275. In several acute myeloid leukemia (AML) cell lines, as well as in U937 cells in combination with doxorubicin, 3i showed higher antiproliferative effects than SAHA.

Published
2014
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99. Biochemical diagnosis of mucopolysaccharidoses: Experience of 297 diagnoses in a 15-year period (1977–1991)

Author

Rita Pallini, Tiziana Annella, T De Luca, G. Spagnuolo, P. Rosario, E. Morabito, Aurora Daniele, P. Di Natale, DI NATALE, P, Annella, T, Daniele, Aurora, DE LUCA, T, Morabito, E, Pallini, R, Rosario, P, and Spagnuolo, G.

Subjects
Adult, Heterozygote, medicine.medical_specialty, Pathology, Adolescent, Period (gene), Mucopolysaccharidosis, Reference Values, Internal medicine, Genotype, Genetics, Humans, Medicine, Lymphocytes, Medical diagnosis, Child, Gene, Genetics (clinical), business.industry, Homozygote, Infant, Heterozygote advantage, Fibroblasts, Mucopolysaccharidoses, medicine.disease, Human genetics, Enzymes, genomic DNA, Italy, Child, Preschool, Lysosomes, business
Abstract

We report the results over 15 years (1977-1991) for biochemical diagnoses of patients referred from throughout Italy and suspected of having a mucopolysaccharidosis. Of these, 147 patients were diagnosed as being homozygous or hemizygous for a specific lysosomal enzyme deficiency; 74 pregnancies at risk were monitored in their families; 76 heterozygote diagnoses were performed on their relatives, with a total of 48 positive diagnoses. We also report the analysis of genomic DNA from 11 unrelated Italian Hunter patients, using pc2S15 probe. DNA from two patients, digested with Pst-I, showed a variant pattern of hybridization caused by deletion or rearrangement of the gene. © 1993 Society for the Study of Inborn Errors of Metabolism and Kluwer Academic Publishers.

Published
1993
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100. MDCT and virtual angioscopy in spontaneous aortocaval fistula

Author

I Romano, Sergio Salerno, Antonio Lo Casto, Teresa De Luca, Salerno, S, Romano, I, De Luca, T, and Lo Casto, A

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Fistula, Angioscopy, Vena Cava, Inferior, Inferior vena cava, Aortography, Aortic aneurysm, User-Computer Interface, Aneurysm, Fatal Outcome, Imaging, Three-Dimensional, cava, Laparotomy, medicine, Humans, fistula, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Aged, MDCT angioscopy, medicine.diagnostic_test, business.industry, virtual angioscopy, Phlebography, medicine.disease, Abdominal aortic aneurysm, aorta, multidetector row ct, medicine.vein, Arteriovenous Fistula, cardiovascular system, Radiographic Image Interpretation, Computer-Assisted, Radiology, Renal vein, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed, Vascular Surgical Procedures, Aortic Aneurysm, Abdominal
Abstract

Aortocaval fistula is a rare, less than 1%, but life threatening complication, of abdominal aortic aneurysm. Mortality is high but prompt recognition of the fistula can reduce mortality rate. The multidetector row CT (MDCT) findings in a 69-year-old patient with a complex medical history characterized by previous episodes of myocardial ischemia, is reported. MDCT shows an early homogeneous enhancement of the inferior vena cava, slightly dilated at the liver level and markedly narrowed above the renal vein due to aneurysm compression. The patient underwent to emergency laparotomy but died during surgery for cardiac arrest. MDCT allows a prompt recognition of the fistula and different computerized reconstruction techniques as maximum intensity projection (MIP), multiplanar reformatting (MPR) and virtual angioscopy (VA) added imaging information for surgery.

Published
2007

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