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Soy protein concentrate was hydrothermally treated at isothermal temperatures of 200, 250, 300, and 350 °C for times up to 60 min to produce a crude bio-oil. Additional product fractions included water-soluble products, gases, and residual solids. We report herein the conversion of protein and gravimetric yields of the different product fractions. The biocrude yield generally increased with both time and temperature as did the yield of gaseous products. The highest biocrude yield was 34%, produced from liquefaction at 350 °C for 60 min. Chemical and physical characterization of the biocrude revealed how its composition and boiling point range changed with reaction time. Finally, we report a reaction network and the parameters for a phenomenological kinetics model that captures the influence of time and temperature on the yields of gas, solid, biocrude, and aqueous-phase products from isothermal hydrothermal liquefaction (HTL) of soy protein concentrate. The reaction network comprised a sole primary path, ...

The prevalence of substructures in $\sim1-10$ Myr old protoplanetary disks, which are often linked to planet formation, has raised the question of how early such features form, and as a corollary, how early planet formation begins. Here we present observations of seven protostellar disks (aged $\sim0.1-1$ Myr) from the VLA/ALMA Nascent Disk and Multiplicity Survey of Orion Protostars (VANDAM: Orion) that show clear substructures, thereby demonstrating that these features can form early in the lifetimes of disks. We use simple analytic models as well as detailed radiative transfer modeling to characterize their structure. In particular we show that at least four of the sources have relatively massive envelopes, indicating that they are particularly young, likely the youngest disks with substructures known to-date. Several of these disks also have emission from an inner disk that is offset from the center of the ring structure. Given the size of the cleared out regions of the disk, it is unclear, however, whether these features are related to planet formation, or rather if they are signposts of close-separation binary formation at early times., 21 pages, 11 figures, 4 tables, accepted for publication in ApJ

The reaction pathways and chemical kinetics of tryptophan and its products were elucidated under hydrothermal conditions from experiments at 265, 280, 295, and 310 °C. Tryptophan participates in several primary reactions leading to the formation of six identified primary products. The primary reactions include decarboxylation, deamination, and cleavage of C–C bonds. Several of the primary products are also formed via secondary reactions. A chemical kinetics model based on the reaction pathways provides excellent correlation of the experimentally observed trends. The model indicates that both the reaction temperature and the initial concentration of tryptophan are influential on the selectivity of the parallel primary reaction pathways, as formation of higher molecular weight products directly from tryptophan is a second order reaction and has the highest activation energy. These new results and the reaction model provide insights into the chemistry that occurs during hydrothermal valorization of proteinaceous biomass.

Characterizing the physical properties and compositions of circumplanetary disks can provide important insights into the formation of giant planets and satellites. We report ALMA 0.88 mm (Band 7) continuum observations of six planetary-mass (10-20 $M_{\rm Jup}$) companions: CT Cha b, 1RXS 1609 b, ROXs 12 b, ROXs 42B b, DH Tau b, and FU Tau b. No continuum sources are detected at the locations of the companions down to 3$\sigma$ limits of 120-210 $\mu$Jy. Given these non-detections, it is not clear whether disks around planetary-mass companions indeed follow the disk flux-host mass trend in the stellar regime. The faint radio brightness of these companion disks may result from a combination of fast radial drift and a lack of dust traps. Alternatively, as disks in binary systems are known to have significantly lower millimeter fluxes due to tidal interactions, these companion disks may instead follow the relationship of moderate-separation binary stars. This scenario can be tested with sensitive continuum imaging at rms levels of $\lesssim$10 $\mu$Jy., Comment: Accepted for publication in AJ

Introduction This survey explored several topics related to living with insomnia/sleeping difficulties. Reported here are patient experience, attitudes, and perspectives about and understanding of prescription medications for insomnia. Methods The online survey was conducted by The Harris Poll in the U.S. between February 14 and March 8, 2019. Survey respondents (“patients”) were adults age ≥18y who had been diagnosed with insomnia (11% of respondents), or had experienced sleeping difficulties (defined as difficulty falling asleep or staying asleep for ≥3 nights/week for ≥3 months; 89% of respondents). Raw survey data were weighted by relevant factors to be representative of the total U.S. adult population with insomnia/sleeping difficulties. Results Among 525 patients (mean age 46y; 55% female) who completed the survey, 83 were currently using prescription medication, 45 used prescription medication previously, and 397 had no prescription medication history. The majority of all patients “somewhat” or “strongly” agreed they were “concerned about the safety risks of sleep medications currently available by prescription” (79%); felt “there have got to be better medications that help people sleep” (74%); and that they “wish there were more medications to choose from” (67%). Within the group of respondents with current/past prescription history (n=128), 63%, 23%, and 14% had tried 1-2, 3-4, or ≥5 different prescription medications, respectively. Among reasons for missing/skipping a dose, ~20% of respondents with current/past prescription history selected for each response that they “do not feel my medication is effective”; “do not like the way my medication makes me feel when I wake up the next morning”; and “prefer not to take my medication every night unless absolutely necessary.” Conclusion Results from this online survey provide insights into patient attitudes toward pharmacotherapy and indicate that a significant number of insomnia patients feel dissatisfied with medication treatment options, including concerns regarding safety and side effects. Support Eisai Inc.

We report Atacama Large Millimeter/submillimeter Array and Very Large Array continuum observations that potentially identify the four youngest protostars in the Orion Molecular Clouds taken as part of the Orion VANDAM program. These are distinguished by bright, extended, irregular emission at 0.87 and 8 mm and are optically thick at 0.87 mm. These structures are distinct from the disk or point-like morphologies seen toward the other Orion protostars. The 0.87 mm emission implies temperatures of 41-170 K, requiring internal heating. The bright 8 mm emission implies masses of 0.5-1.2 M o˙ assuming standard dust opacity models. One source has a Class 0 companion, while another exhibits substructure indicating a companion candidate. Three compact outflows are detected, two of which may be driven by companions, with dynamical times of ∼300 to ∼1400 yr. The slowest outflow may be driven by a first hydrostatic core. These protostars appear to trace an early phase when the centers of collapsing fragments become optically thick to their own radiation and compression raises the gas temperature. This phase is thought to accompany the formation of hydrostatic cores. A key question is whether these structures are evolving on freefall times of ∼100 yr, or whether they are evolving on Kelvin-Helmholtz times of several thousand years. The number of these sources imply a lifetime of ∼6000 yr, in closer agreement with the Kelvin-Helmholtz time. In this case, rotational and/or magnetic support could be slowing the collapse. © 2020. The American Astronomical Society. All rights reserved., We wish to thank the anonymous referee for insightful comments and suggestions that improved the quality of this manuscript. The authors acknowledge Lee Hartmann for the useful discussions and many insightful comments. Support for Nicole Karnath was provided by the NSF through award SOSP AST-1519126 from the NRAO and by the NASA Origin of the Solar System program 13-OSS13-0094 (Megeath PI for both). This work made use of the SIMBAD database, the Vizier database, and the NASA Astrophysics Data System, funded by the National Aeronautics and Space Administration and the NSF. A.S. acknowledges funding through Fondecyt regular (project code 1180350), "Concurso Proyectos Internacionales de Investigacion" (project code PII20150171), and Chilean Centro de Excelencia en Astrofisica y Tecnologias Afines (CATA) BASAL grant AFB-170002. J.J.T. acknowledges funding from the National Science Foundation AST-1814762. Z.Y.L. is supported in part by NSF 1716259 and NASA 80NSSC18K1095. G.A., M.O., and A.K.D.-R. acknowledge financial support from the State Agency for Research of the Spanish MCIU through the AYA2017-84390-C2-1-R grant (co-funded by FEDER) and through the "Center of Excellence Severo Ochoa" award for the Instituto de Astrofisica de Andalucia (SEV2017-0709). This research was conducted in part at the SOFIA Science Center, which is operated by the Universities Space Research Association under contract NNA17BF53C with the National Aeronautics and Space Administration. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. This paper makes use of the following ALMA data: ADS/JAO.ALMA#2015.1.00041.S. ALMA is a partnership of ESO (representing its member states), NSF (USA), and NINS (Japan), together with NRC (Canada), MOST and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO and NAOJ.

We present ALMA 850 $\mu$m continuum observations of the Orion Nebula Cluster that provide the highest angular resolution ($\sim 0\rlap{.}''1 \approx 40$ AU) and deepest sensitivity ($\sim 0.1$ mJy) of the region to date. We mosaicked a field containing $\sim 225$ optical or near-IR-identified young stars, $\sim 60$ of which are also optically-identified "proplyds". We detect continuum emission at 850 $\mu$m towards $\sim 80$% of the proplyd sample, and $\sim 50$% of the larger sample of previously-identified cluster members. Detected objects have fluxes of $\sim 0.5$-80 mJy. We remove sub-mm flux due to free-free emission in some objects, leaving a sample of sources detected in dust emission. Under standard assumptions of isothermal, optically thin disks, sub-mm fluxes correspond to dust masses of $\sim 0.5$ to 80 Earth masses. We measure the distribution of disk sizes, and find that disks in this region are particularly compact. Such compact disks are likely to be significantly optically thick. The distributions of sub-mm flux and inferred disk size indicate smaller, lower-flux disks than in lower-density star-forming regions of similar age. Measured disk flux is correlated weakly with stellar mass, contrary to studies in other star forming regions that found steeper correlations. We find a correlation between disk flux and distance from the massive star $\theta^1$ Ori C, suggesting that disk properties in this region are influenced strongly by the rich cluster environment., Comment: Accepted for publication in ApJ

We report the detection of methanol in the disk around the young outbursting star V883 Ori with the Atacama Large Millimeter/submillimeter Array (ALMA). Four transitions are observed with upper level energies ranging between 115 and 459 K. The emission is spatially resolved with the 0.14" beam and follows the Keplerian rotation previously observed for C$^{18}$O. Using a rotational diagram analysis, we find a disk-averaged column density of $\sim10^{17}$ cm$^{-2}$ and a rotational temperature of $\sim90-100$ K, suggesting that the methanol has thermally desorbed from the dust grains. We derive outer radii between 120 and 140 AU for the different transitions, compared to the 360 AU outer radius for C$^{18}$O. Depending on the exact physical structure of the disk, the methanol emission could originate in the surface layers beyond the water snowline. Alternatively, the bulk of the methanol emission originates inside the water snowline, which can then be as far out as ~100 AU, instead of 42 AU as was previously inferred from the continuum opacity. In addition, these results show that outbursting young stars like V883 Ori are good sources to study the ice composition of planet forming material through thermally desorbed complex molecules, which have proven to be hard to observe in more evolved protoplanetary disks., Comment: 8 pages, 4 figures, 1 table. Accepted for publication in ApJL

HD 100453AB is a 10+/-2 Myr old binary whose protoplanetary disk was recently revealed to host a global two-armed spiral structure. Given the relatively small projected separation of the binary (1.05", or ~108 au), gravitational perturbations by the binary seemed to be a likely driving force behind the formation of the spiral arms. However, the orbit of these stars remained poorly understood, which prevented a proper treatment of the dynamical influence of the companion on the disk. We observed HD 100453AB between 2015-2017 utilizing extreme adaptive optics systems on the Very Large Telescope and Magellan Clay Telescope. We combined the astrometry from these observations with published data to constrain the parameters of the binary's orbit to a=1.06"+/-0.09", e=0.17+/-0.07, and i=32.5+/- 6.5 degrees. We utilized publicly available ALMA CO data to constrain the inclination of the disk to i~28 degrees, which is relatively co-planar with the orbit of the companion and consistent with previous estimates from scattered light images. Finally, we input these constraints into hydrodynamical and radiative transfer simulations to model the structural evolution of the disk. We find that the spiral structure and truncation of the circumprimary disk in HD 100453 are consistent with a companion-dirven origin. Furthermore, we find that the primary star's rotation, its outer disk, and the companion exhibit roughly the same direction of angular momentum, and thus the system likely formed from the same parent body of material., Comment: 28 pages, 11 figures, Accepted to ApJ

Until recently exergaming was seldom a topic of research. The technology that makes exergaming possible was not available to consumers. In 2006, Nintendo released the Wii gaming system. This new system allowed for interactive physical movement beyond simple hand held play. The Wii system contained hardware and software that responded to movements of the player's body through the tracking of hand held controllers and movements of the lower extremities using floor based hardware. Exergaming appears poised to continue its foray into popular culture for better or worse. After nearly a decade of research a single theory for exergames has not been suggested. Previous researchers have relied on existing theories to guide them. Over a dozen theories have been used by authors of research into exergaming. With all of this research and the many theories that have been used it is time for an examination of these theories as to their relevance for exergaming. This paper endeavors to review the existing literature to identify what theories are being used in research and to delineate what the components of each theory are. A literature review was conducted using the Trident International University online library. This library allowed access to the ProQuest Summon® Service search engine which allowed for a search of multiple libraries including Blackwell, Gale, LexisNexis, Academic, Sage, Springer, Emerald, ProQuest, Taylor & Francis, IEEE, and Project Muse resulting in a search of more than 6,800 publishers and 94,000 journal and periodical titles. There are over a dozen theories found in the literature on exergaming. This paper endeavors to examine how often each theory appears in the literature while providing a brief overview of each theory. In the final analysis, the theory chosen for exergame research will be determined by the type of study undertaken.

With the novelty of exergames, an alternative form of entertainment and exercise emerged especially for physical education (PE). While video games have been historically associated to problems such as obesity, social introversion and aggressive behavior, exergames brought a new perspective in which these cultural artifacts could contribute to people's education concerning the practice of physical activity. This article presents a study about the setting up of an exergame lab focusing on kids and preadolescents who usually show signs of dissatisfaction with PE. The research methodology followed a qualitative observation approach, involving twenty-four students of both genders for three months. Results demonstrated that students who were normally unmotivated to participate in PE classes showed a positive attitude regarding the exergame practices and demonstrated their willingness to collaborate with peers. The study also showed that exergaming provides situations in which students can increase the regularity of their practice of physical exercises.

A kinetic model for the hydrothermal liquefaction (HTL) of microalgae was developed and its performance in predicting biocrude yields was tested. Kinetic interactions between algal proteins, carbohydrates, and lipids were also included for the first time. These interactions provided a better fit of the data used to determine model parameters, but the kinetics model lacking interactions provided a better prediction of published biocrude yields. This model predicted 70 published biocrude yields to within ±5 wt% given the biochemical composition of the alga and the HTL temperature and time as model inputs. Forty-two other published biocrude yields were predicted to within ±10 wt%. The model accurately predicts that feedstocks richer in proteins or lipids give higher biocrude yields than those abundant in carbohydrates. This updated model better predicts the combined influences of HTL reaction conditions and algae biochemical composition on HTL biocrude yields than any other model currently available.

Class I protostars are thought to represent an early stage in the lifetime of protoplanetary disks, when they are still embedded in their natal envelope. Here we measure the disk masses of 10 Class I protostars in the Taurus Molecular Cloud to constrain the initial mass budget for forming planets in disks. We use radiative transfer modeling to produce synthetic protostar observations and fit the models to a multi-wavelength dataset using a Markov Chain Monte Carlo fitting procedure. We fit these models simultaneously to our new CARMA 1.3 mm observations that are sensitive to the wide range of spatial scales that are expected from protostellar disks and envelopes so as to be able to distinguish each component, as well as broadband spectral energy distributions compiled from the literature. We find a median disk mass of 0.018 M$_{\odot}$ on average, more massive than the Taurus Class II disks, which have median disk mass of $\sim$0.0025 M$_{\odot}$. This decrease in disk mass can be explained if dust grains have grown by a factor of 75 in grain size, indicating that by the Class II stage, at a few Myr, a significant amount of dust grain processing has occurred. However, there is evidence that significant dust processing has occurred even during the Class I stage, so it is likely that the initial mass budget is higher than the value quoted here., Comment: 29 pages, 5 figures, 2 tables, ApJ, in press

Multi-wavelength observations provide a complementary view of the formation of young directly-imaged planet-mass companions. We report the ALMA 1.3 mm and Magellan adaptive optics (MagAO) H-alpha, i', z', and Ys observations of the GQ Lup system, a classical T Tauri star with a 10-40 Mjup substellar companion at ~110 AU projected separation. We estimate the accretion rates for both components from the observed H-alpha fluxes. In our 0.05 arcsec resolution ALMA map, we resolve GQ Lup A's disk in dust continuum, but no signal is found from the companion. The disk is compact, with a radius of ~22 AU, a dust mass of ~6 Earth masses, an inclination angle of ~56 deg, and a very flat surface density profile indicative of a radial variation in dust grain sizes. No gaps or inner cavity are found in the disk, so there is unlikely a massive inner companion to scatter GQ Lup B outward. Thus, GQ Lup B might have formed in situ via disk fragmentation or prestellar core collapse. We also show that GQ Lup A's disk is misaligned with its spin axis, and possibly with GQ Lup B's orbit. Our analysis on the tidal truncation radius of GQ Lup A's disk suggests that GQ Lup B's orbit might have a low eccentricity., Comment: Accepted for publication in ApJ

Traditional fixed-effects models based on nonlinear least squares or Bayesian methods of rate parameter estimation for batch reactor longitudinal data are problematic because such methods assume statistical independence between all measurements across multiple batches. For multiple longitudinal experiments, which yield time series data, such assumptions of independence are clearly inappropriate. Therefore, we investigate the application of nonlinear mixed-effects models for batch reactor experiments. Investigators in other fields use nonlinear mixed-effects models extensively to estimate accurate and nonbiased parameters for data sets with multiple correlated measurements. Such models may be superior for modeling batch reactor longitudinal experiments. Using single response data from a batch recycle trickle bed reactor system for the hydrogenation of acetophenone to 1-phenylethanol over a copper catalyst, we show less correlated parameters as well as improved lag plots and run sequence plots from a mixed-effects model relative to a fixed-effects Bayesian model.

Purpose To test whether reducing radiation dose to uninvolved bladder while maintaining dose to the tumor would reduce side effects without impairing local control in the treatment of muscle-invasive bladder cancer. Methods and Materials In this phase III multicenter trial, 219 patients were randomized to standard whole-bladder radiation therapy (sRT) or reduced high-dose volume radiation therapy (RHDVRT) that aimed to deliver full radiation dose to the tumor and 80% of maximum dose to the uninvolved bladder. Participants were also randomly assigned to receive radiation therapy alone or radiation therapy plus chemotherapy in a partial 2 × 2 factorial design. The primary endpoints for the radiation therapy volume comparison were late toxicity and time to locoregional recurrence (with a noninferiority margin of 10% at 2 years). Results Overall incidence of late toxicity was less than predicted, with a cumulative 2-year Radiation Therapy Oncology Group grade 3/4 toxicity rate of 13% (95% confidence interval 8%, 20%) and no statistically significant differences between groups. The difference in 2-year locoregional recurrence free rate (RHDVRT − sRT) was 6.4% (95% confidence interval −7.3%, 16.8%) under an intention to treat analysis and 2.6% (−12.8%, 14.6%) in the "per-protocol" population. Conclusions In this study RHDVRT did not result in a statistically significant reduction in late side effects compared with sRT, and noninferiority of locoregional control could not be concluded formally. However, overall low rates of clinically significant toxicity combined with low rates of invasive bladder cancer relapse confirm that (chemo)radiation therapy is a valid option for the treatment of muscle-invasive bladder cancer.

Objective Carpal tunnel syndrome (CTS) is a common median nerve entrapment neuropathy characterized by pain, paresthesias, diminished peripheral nerve conduction velocity (NCV) and maladaptive functional brain neuroplasticity. We evaluated structural reorganization in brain gray matter (GM) and white matter (WM) and whether such plasticity is linked to altered median nerve function in CTS. Methods We performed NCV testing, T1-weighted structural MRI, and diffusion tensor imaging (DTI) in 28 CTS and 28 age-matched healthy controls (HC). Voxel-based morphometry (VBM) contrasted regional GM volume for CTS versus HC. Significant clusters were correlated with clinical metrics and served as seeds to define associated WM tracts using DTI data and probabilistic tractography. Within these WM tracts, fractional anisotropy (FA), axial (AD) and radial (RD) diffusivity were evaluated for group differences and correlations with clinical metrics. Results For CTS subjects, GM volume was significantly reduced in contralesional S1 (hand-area), pulvinar and frontal pole. GM volume in contralesional S1 correlated with median NCV. NCV was also correlated with RD and was negatively correlated with FA within U-fiber cortico-cortical association tracts identified from the contralesional S1 VBM seed. Conclusions Our study identified clear morphometric changes in the CTS brain. This central morphometric change is likely secondary to peripheral nerve pathology and altered somatosensory afference. Enhanced axonal coherence and myelination within cortico-cortical tracts connecting primary somatosensory and motor areas may accompany peripheral nerve deafferentation. As structural plasticity was correlated with NCV and not symptomatology, the former may be a better determinant of appropriate clinical intervention for CTS, including surgery., Highlights ► CTS demonstrated reduced GM volume in S1, pulvinar, and frontal pole. ► GM volume in S1 was significantly correlated with median nerve conduction velocity. ► Median nerve velocity was linked to WM microstructure in tracts connected to S1.

We present ALMA observations of the Orion Nebula that cover the OMC1 outflow region. Our focus in this paper is on compact emission from protoplanetary disks. We mosaicked a field containing $\sim 600$ near-IR-identified young stars, around which we can search for sub-mm emission tracing dusty disks. Approximately 100 sources are known proplyds identified with HST. We detect continuum emission at 1 mm wavelengths towards $\sim 20\%$ of the proplyd sample, and $\sim 8\%$ of the larger sample of near-IR objects. The noise in our maps allows 4$\sigma$ detection of objects brighter than $\sim 1.5$ mJy, corresponding to protoplanetary disk masses larger than 1.5 M$_{\rm J}$ (using standard assumptions about dust opacities and gas-to-dust ratios). None of these disks are detected in contemporaneous CO(2-1) or C$^{18}$O(2-1) observations, suggesting that the gas-to-dust ratios may be substantially smaller than the canonical value of 100. Furthermore, since dust grains may already be sequestered in large bodies in ONC disks, the inferred masses of disk solids may be underestimated. Our results suggest that the distribution of disk masses in this region is compatible with the detection rate of massive planets around M dwarfs, which are the dominant stellar constituent in the ONC., Comment: Accepted for publication in ApJ

13 p., While autonomic outflow is an important co-factor of nausea physiology, central control of this outflow is poorly understood. We evaluated sympathetic (skin conductance level) and cardiovagal (high-frequency heart rate variability) modulation, collected synchronously with functional MRI (fMRI) data during nauseogenic visual stimulation aimed to induce vection in susceptible individuals. Autonomic data guided analysis of neuroimaging data, using a stimulus-based (analysis windows set by visual stimulation protocol) and percept-based (windows set by subjects’ ratings) approach. Increased sympathetic and decreased parasympathetic modulation was associated with robust and anti-correlated brain activity in response to nausea. Specifically, greater autonomic response was associated with reduced fMRI signal in brain regions such as the insula, suggesting an inhibitory relationship with premotor brainstem nuclei. Interestingly, some sympathetic/parasympathetic specificity was noted. Activity in default mode network and visual motion areas was anti-correlated with parasympathetic outflow at peak nausea. In contrast, lateral prefrontal cortical activity was anticorrelated with sympathetic outflow during recovery, soon after cessation of nauseogenic stimulation. These results suggest divergent central autonomic control for sympathetic and parasympathetic response to nausea. Autonomic outflow and the central autonomic network underlying ANS response to nausea may be an important determinant of overall nausea intensity and, ultimately, a potential therapeutic target.

We present Karl G. Janksy Very Large Array (VLA) 1.3 cm, 3.6 cm, and 6 cm continuum maps of compact radio sources in the Orion Nebular Cluster. We mosaicked 34 square arcminutes at 1.3 cm, 70 square arcminutes at 3.6 cm and 109 square arcminutes at 6 cm, containing 778 near-infrared detected YSOs and 190 HST-identified proplyds (with significant overlap between those characterizations). We detected radio emission from 175 compact radio sources in the ONC, including 26 sources that were detected for the first time at these wavelengths. For each detected source we fit a simple free-free and dust emission model to characterize the radio emission. We extrapolate the free-free emission spectrum model for each source to ALMA bands to illustrate how these measurements could be used to correctly measure protoplanetary disk dust masses from sub-millimeter flux measurements. Finally, we compare the fluxes measured in this survey with previously measured fluxes for our targets, as well as four separate epochs of 1.3 cm data, to search for and quantify variability of our sources., Comment: 13 pages, 6 figures, 4 tables, ApJ, in press

The purpose of this research was to probe the philosophical beliefs of instructional designers using sound philosophical constructs and quantitative data collection and analysis. We investigated the philosophical and methodological beliefs of instructional designers, including 152 instructional design faculty members and 118 non-faculty professionals. We used the Philosophy of Social Science Inventory, a 52-item questionnaire, to measure 20 beliefs within four categories. We probed four ontological beliefs (ontological realism, ontological relativism, physicalism, and idealism); five epistemological beliefs (epistemological relativism, fallibilism, epistemological objectivity, rationalism, and empiricism); three axiological beliefs (ethical realism, ethical relativism, and valueneutrality in research); and eight methodological beliefs (nomothetic, idiographic and critical methods, scientific naturalism, humanism, and quantitative, qualitative and mixed methods). Our research questions included (a) What are the predominant philosophical and methodological beliefs of instructional designers? (b) Do instructional design faculty and non-faculty instructional designers, identifying with different research methodologies, hold different sets of philosophical beliefs? and (c) What relationships exist between philosophical beliefs and age, gender, ethnicity, level of education, and/or years of service? Overall, the philosophical profile of instructional designers can reasonably be described as pragmatic. Belief characterizations of methodological subgroups (e.g., those identifying with qualitative, quantitative, or mixed methods research) generally supported our hypotheses. Although demographic variables (except gender) were not singularly important, our analyses suggest that a combination of ethnicity, gender, research preference, and level of education can be used to predict philosophical and methodological beliefs.

ObjectivesMental disorder is common among individuals with neurological illness. We aimed to characterise the patient population referred for psychiatry assessment at a tertiary neurology service in terms of neurological and psychiatric diagnoses and interventions provided.MethodsWe studied all individuals referred for psychiatry assessment at a tertiary neurology service over a 2-year period (n= 82).ResultsThe most common neurological diagnoses among those referred were epilepsy (16%), Parkinson’s disease (15%) and multiple sclerosis (8%). The most common reasons for psychiatric assessment were low mood or anxiety (48%) and medically unexplained symptoms or apparent functional or psychogenic disease (21%). The most common diagnoses among those with mental disorder were mood disorders (62%), and neurotic, stress-related and somatoform disorders, including dissociative (conversion) disorders (28%). Psychiatric diagnosis was not related to gender, neurological diagnosis or psychiatric history.ConclusionIndividuals with neurological illness demonstrate significant symptoms of a range of mental disorders. There is a need for further research into the characteristics and distribution of mental disorder in individuals with neurological illness, and for the enhancement of integrated psychiatric and neurological services to address the comorbidities demonstrated in this population.

We present the highest spatial resolution ALMA observations to date of the Class I protostar GY 91 in the $\rho$ Ophiuchus L1688 molecular cloud complex. Our 870 $\mu$m and 3 mm dust continuum maps show that the GY 91 disk has a radius of $\sim$80 AU, and an inclination of $\sim$40$^{\circ}$, but most interestingly that the disk has three dark lanes located at 10 AU, 40 AU, and 70 AU. We model these features assuming they are gaps in the disk surface density profile and find that their widths are 7 AU, 30 AU, and 10 AU. These gaps bear a striking resemblance to the gaps seen in the HL Tau disk, suggesting that there may be Saturn-mass planets hiding in the disk. To constrain the relative ages of GY 91 and HL Tau, we also model the disk and envelope of HL Tau and find that they are of similar ages, although GY 91 may be younger. Although snow lines and magnetic dead zones can also produce dark lanes, if planets are indeed carving these gaps then Saturn-mass planets must form within the first $\sim$0.5 Myr of the lifetime of protoplanetary disks., Comment: 9 pages, 6 figures, 2 tables. Accepted for publication in ApJ

We have rereduced Spitzer IRS spectra and reanalyzed the SED's of three nearby debris disks: lambda Boo, HD 139664, and HR 8799. We find that that the thermal emission from these objects is well modeled using two single temperature black body components. For HR 8799 -- with no silicate emission features despite a relatively hot inner dust component (Tgr = 150 K) -- we infer the presence of an asteroid belt interior to and a Kuiper Belt exterior to the recently discovered orbiting planets. For HD 139664, which has been imaged in scattered light, we infer the presence of strongly forward scattering grains, consistent with porous grains, if the cold, outer disk component generates both the observed scattered light and thermal emission. Finally, careful analysis of the lambda Boo SED suggests that this system possesses a central clearing, indicating that selective accretion of solids onto the central star does not occur from a dusty disk., 8 pages, 2 figures (including 2 color figures), ApJ, in press

Bivalves are of major importance in aquatic ecology, aquaculture, are widely used as sentinel species in environmental toxicology and show remarkable plasticity to molecular oxygen. Excess reactive oxygen species (ROS) arising from molecular oxygen can cause oxidative stress and this is also a consequence of exposure to many common environmental pollutants. Indices of oxidative stress have therefore found favor as biomarkers of exposure and effect in environmental toxicology. However, there is a growing body of literature on the use of discovery-led proteomics methods to detect oxidative stress in bivalves. This is because proteins absorb up to 70 % of ROS leading to complication of the proteome. This article explores the background to these developments and assesses the practice and future potential of proteomics in the study of oxidative stress in bivalves.

Advanced prostate cancer patients frequently deal with intractable prostatic bleeding which is a difficult problem to manage. Intraurethral high-dose rate (HDR) brachytherapy may palliate this condition. Advanced prostate cancer patients with intractable prostatic bleeding were offered brachytherapy with Iridium-192 using a Micro-selectron HDR machine. During a 5-year period, analysis was performed in 23 patients with a median age and Gleason score of 78 years and 9, respectively. Following brachytherapy, haematuria resolved in 19 of the 23 patients and was recurrence free at 6 months. Intraurethral HDR brachytherapy is a potentially effective modality for treating haematuria in patients with advanced prostate cancer.

Much has been gained over the years in various educational fields that have taken advantage of CALL. In many cases, CALL has facilitated learning and provided teachers and students access to materials and tools that would have remained out of reach were it not for technology. Nonetheless, there are still cases where a lack of funding or access to CALL tools prevents teachers and students from reaping the benefits of CALL. Furthermore, in countries inundated by technology, opportunities for students to create and collaborate using CALL may get lost amid the noise of the latest program, or the trendiest learning tools. The project described in this article involves students in a different way to use CALL for learning; it has them work together using technology, troubleshooting problems, and creating online news stories. This article describes a digital journalism simulation called JUEMUN Journalism. JUEMUN, the Japan English University Model United Nations, is an annual event that brings together students from around the globe to participate in a Model United Nations (MUN). A component of this event includes teams of journalists who cover the events at the MUN, and report on them in four formats: podcasts, video broadcasts, a written chronicle, and editorial cartoons.

We have surveyed 84 Class 0, Class I, and flat-spectrum protostars in mid-infrared [Si II], [Fe II] and [S I] line emission, and 11 of these in far-infrared [O I] emission. We use the results to derive their mass outflow rates. Thereby we observe a strong correlation of mass outflow rates with bolometric luminosity, and with the inferred mass accretion rates of the central objects, which continues through the Class 0 range the trend observed in Class II young stellar objects. Along this trend from large to small mass-flow rates, the different classes of young stellar objects lie in the sequence Class 0 -- Class I/flat-spectrum -- Class II, indicating that the trend is an evolutionary sequence in which mass outflow and accretion rates decrease together with increasing age, while maintaining rough proportionality. The survey results include two which are key tests of magnetocentrifugal outflow-acceleration mechanisms: the distribution of the outflow/accretion branching ratio b, and limits on the distribution of outflow speeds. Neither rule out any of the three leading outflow-acceleration, angular-momentum-ejection mechanisms, but they provide some evidence that disk winds and accretion-powered stellar winds (APSWs) operate in many protostars. An upper edge observed in the branching-ratio distribution is consistent with the upper bound of b = 0.6 found in models of APSWs, and a large fraction (0.31) of the sample have branching ratio sufficiently small that only disk winds, launched on scales as large as several AU, have been demonstrated to account for them., Version submitted to ApJ: 36 pages, 3 tables, 8 figures

This chapter will show different ways that graded readers, hereafter referred to as GR, can be used to increase English language learning motivation, deepen knowledge of specialized content and refine discussion skills among higher-level learners. The benefits of using graded reading to provide input to second language learners may be well known to language educators and researchers in various fields. ‘Language acquisition comes from input, not output; from comprehension, not production’ (Krashen, 2004: 136). Furthermore, upper-intermediate books from GR series can be used to provide motivated higher-level learners with background information and contexts in the form of challenging and interesting content that can facilitate deeper thinking and discussions about culture, history and literature, i.e. the very types of exchange that literature students take part in.

Only 1251 three-dimensional structures for bovine proteins are currently in the protein data bank (PDB), compared with over 60,000 protein sequences, demonstrating a large gap between knowledge of sequences and three-dimensional structures. An alternative approach to obtaining protein structures experimentally is to use homology modelling. In this paper, online homology modelling with Geno3D was used to create structural models for selected milk enzymes, i.e., lysozyme, alkaline phosphatase, lactoperoxidase, lipoprotein lipase, and cathepsin D. Models were also generated for the N-terminal and catalytic domains of plasmin. The models generated were assessed in terms of their geometry, Ramachandran diagrams and root mean-square deviation from targets. Generally, models were plausible and provided a first approach to protein structure for enzymes for which an experimentally determined three-dimensional structure is as yet unavailable. As a positive control, bovine chymosin (which is in the PDB) was modelled on the 38% homologous human protein and the resulting structure shown to be very similar to the experimentally determined crystal structure.

Litterfall can be an important flux of mercury (Hg) to soils in forested landscapes, yet typically the only available data to evaluate Hg deposition is from precipitation Hg monitoring. Litterfall was collected at 39 sampling sites in two small research watersheds, in 2003 and 2004, and analyzed for total Hg. Four vegetation classes were designated in this study as hardwoods, softwoods, mixed and scrub. The mean litter Hg concentration in softwoods (58.8 ± 3.3 ng Hg g−1 was significantly greater than in mixed (41.7 ± 2.8 ng Hg g−1 and scrub (40.6 ± 2.7 ng Hg g−1, and significantly lower than in hardwoods (31.6 ± 2.6 ng Hg g−1. In contrast, the mean weighted litter Hg flux was not significantly different among vegetation classes. The lack of a significant difference in litter Hg flux between hardwoods and softwoods was attributable to the large autumnal hardwood litter Hg flux being balanced by the higher softwood litter Hg concentrations, along with the higher chronic litterfall flux throughout the winter and spring in softwoods. The estimated annual deposition of Hg via litterfall in Hadlock Brook watershed (10.1 μg m−2 and Cadillac Brook watershed (10.0 μg m−2 was greater than precipitation Hg deposition and similar to or greater than the magnitude of Hg deposition via throughfall. These results demonstrate that litterfall Hg flux to forested landscapes can be at least as important as precipitation Hg inputs.

We report Atacama Large Millimeter/submillimeter Array (ALMA) 1.3 mm continuum upper limits for 5 planetary-mass companions DH Tau B, CT Cha B, GSC 6214-210 B, 1RXS 1609 B, and GQ Lup B. Our survey, together with other ALMA studies, have yielded null results for disks around young planet-mass companions and placed stringent dust mass upper limits, typically less than 0.1 M_earth, when assuming dust continuum is optically thin. Such low-mass gas/dust content can lead to a disk lifetime estimate (from accretion rates) much shorter than the age of the system. To alleviate this timescale discrepancy, we suggest that disks around wide companions might be very compact and optically thick, in order to sustain a few Myr of accretion yet have very weak (sub)millimeter flux so as to still be elusive to ALMA. Our order-of-magnitude estimate shows that compact optically-thick disks might be smaller than 1000 R_jup and only emit ~micro-Jy of flux in the (sub)millimeter, but their average temperature can be higher than that of circumstellar disks. The high disk temperature could impede satellite formation, but it also suggests that mid- to far-infrared might be more favorable than radio wavelengths to characterize disk properties. Finally, the compact disk size might imply that dynamical encounters between the companion and the star, or any other scatterers in the system, play a role in the formation of planetary-mass companions., Comment: Accepted for publication in AJ

We present the highest spatial resolution ALMA observations to date of the Class I protostar WL 17 in the $\rho$ Ophiuchus L1688 molecular cloud complex, which show that it has a 12 AU hole in the center of its disk. We consider whether WL 17 is actually a Class II disk being extincted by foreground material, but find that such models do not provide a good fit to the broadband SED and also require such high extinction that it would presumably arise from dense material close to the source such as a remnant envelope. Self-consistent models of a disk embedded in a rotating collapsing envelope can nicely reproduce both the ALMA 3 mm observations and the broadband SED of WL 17. This suggests that WL 17 is a disk in the early stages of its formation, and yet even at this young age the inner disk has been depleted. Although there are multiple pathways for such a hole to be created in a disk, if this hole were produced by the formation of planets it could place constraints on the timescale for the growth of planetesimals in protoplanetary disks., Comment: 7 pages, 3 figures, 2 tables, accepted for publication in ApJL

239 Background: In the COU-AA-302 trial, abiraterone acetate plus prednisone (AAP) resulted in extension of radiographic progression-free survival (rPFS) and overall survival in chemotherapy-naïve mCRPC patients compared to prednisone alone. However, limited data on AAP treatment and outcomes is available in the real-world in this setting. The aim of this study is to describe the duration of AAP treatment in routine clinical practice in mCRPC patients prior to chemotherapy. Methods: The study was designed as a retrospective chart review of mCRPC patients identified through oncology and urology practice in Belgium, France, Germany and the UK. This first analysis reports baseline patient characteristics at AAP initiation for the first 224 patients. Treatment duration, PFS and rPFS were estimated using Kaplan-Meier curves. Potential factors associated with treatment duration were explored using the log-rank test. Results: Data from 224 mCRPC patients treated with AAP (Belgium: 67; Germany: 150; UK: 7; none from France) across 19 centres was considered in this initial analysis. At baseline, the median age was 75.5 years (interquartile range [IQR]: 69.0-82.0) and the median PSA level was 50.0 ng/mL (IQR: 21.0-121.0). Patients with visceral metastases (9.8%) and ECOG 2-3 (9.4%) were included in this study, in contrast to those included in the COU-AA-302 study. Median duration of AAP treatment was 11.6 months (95% confidence interval [CI]: 10.2-12.8), whilst median PFS and rPFS were 11.9 months (95% CI: 10.8-13.3) and 16.5 months (95% CI: 13.5-20.0), respectively. Reasons for discontinuing AAP involved PSA progression (52.2%), radiographic progression (38.9%), symptomatic progression (27.8%), non-toxic death (19.4%) and toxicity (2.2%). Treatment duration was significantly longer in mCRPC patients with either baseline ECOG status 0, lower PSA, alkaline phosphatase, aspartate aminotransferase, or lactate dehydrogenase levels (p < 0.05). Conclusions: The results of this study suggest similar treatment duration and rPFS for mCRPC patients in this real-life cohort with poorer clinical features compared to those observed in the COU-AA-302 trial population.

The online version of the original article can be found under doi:10.1007/s11423-011-9220-7.M. D. Sheehan (&) R. B. JohnsonUniversity of South Alabama, Mobile, AL, USAe-mail: msheehan@usouthal.eduTable 3 Philosophical belief differences by method preferencePhilosophical belief Method preference in descendingorderM Significantly different pairsof meansPhysicalism Quantitative 2.82 Qualitative vs. quantitativeMixed 2.43 Mixed vs. quantitativeQualitative 2.23Idealism Qualitative 3.78 Qualitative vs. quantitativeMixed 3.51Quantitative 3.21Ontological realism nsOntological relativism Qualitative 4.11 Qualitative vs. quantitativeMixed 3.69Quantitative 3.22

Background: The literature and research on nursing ethics and advocacy has shown that generally very few nurses and other clinicians will speak up about an issue they have witnessed regarding a patient advocacy concern and that often advocacy in nursing is not learned until after students have graduated and begun working. Objective: To evaluate the effectiveness of narrative pedagogy on the development of advocacy in student nurses, as measured by the Protective Nursing Advocacy Scale. Design: We tested the hypothesis that use of a narrative pedagogy assignment related to ethics would improve student nurse’s perception of their advocacy role as measured by the Protective Nursing Advocacy Scale using a quasi-experimental nonrandomized study using a pre-test, intervention, post-test design. Data collection occurred during class time from October 2012 to December 2012. The Protective Nursing Advocacy Scale tool was administered to students in class to assess their baseline and was administered again at the completion of the educational intervention to assess whether narrative pedagogy was effective in developing the nursing student’s perception of their role as a patient advocate. Ethical considerations: Students were informed that their participation was voluntary and that the data collected would be anonymous and confidential. The survey was not a graded assignment, and students did not receive any incentive to participate. The institutional review board of the college determined the study to be exempt from review. Setting: School of Nursing at a small liberal arts college in the Northeastern United States. Participants: A consecutive, nonprobability sample of 44 senior-level nursing students enrolled in their final nursing semester was utilized. Findings: Results indicated significant differences in student nurse’s perception of their advocacy role related to environment and educational influences following an education intervention using an ethics digital story. Conclusion: Using the Protective Nursing Advocacy Scale, we were able to measure the effectiveness of narrative pedagogy on nursing student’s perception of the nurse’s advocacy role.

This paper presents a theoretically-based methodology that was used to enable the development of instructional objectives and media recommendations for training Military Flight Officers in Situation Awareness (SA). The research was conducted during a Training Situation Analysis already in progress. A set of behaviors theoretically linked to SA was empirically validated during 12 training flights at a Naval air station. Data was also collected concerning the criticality and difficulty to perform for each behavior, and the adequacy of the current training aircraft and simulators to provide the required training. Finally, two measures of structural knowledge were used to elicit mental model representations to identify the relationships among the behaviors. The process serves as an example of theory-to-practice in a real-world context.

The apolipoprotein (Apo) E gene, and thus its gene product, plays a central and pervasive role in lipid metabolism by serving as a ligand for lipoprotein receptors. Polymorphisms of this gene have been associated with variation in lipid phenotypes in some Caucasian and Asian populations, but not in others. No such study has been carried out in a resident Irish population.A study was designed to examine the relationship between serum cholesterols and Apo E genotype in a cohort of healthy Irish adults.One hundred healthy Irish adults, aged 19-65 years, were recruited from the Cork City area. Two fasting blood samples were collected from each subject. One was assayed for serum cholesterols--total and low-density lipoprotein (LDL), and high-density lipoprotein (HDL)--while the other sample was used for isolation of genomic DNA and determination of Apo E genotype.While the E2 (12%) was the least prevalent, E3 was the most prevalent Apo E genotype (66%) in this group of healthy Irish adults. A significant Apo E gene-dosage effect was evident, whereby individuals with the Apo E2 genotype had a lower level of total cholesterol, E3 had intermediate levels, and E4 had a higher level. Moreover, those with the Apo E4 genotype had a significantly higher level of LDL cholesterol compared to E2 or E3 genotypes. There was no significant difference in mean serum adjusted HDL-cholesterol levels between the three Apo E genotypes.These findings suggest that healthy Irish adults with the Apo E4 genotype have higher serum total and LDL-cholesterol levels than those with E2 or E3 Apo E genotypes and therefore may have a higher risk of atherosclerotic coronary artery disease and coronary heart disease in later life.

Vital population parameters, such as growth, survival, recruitment, reproduction, distribution, and abundance, are the consequences of life history modes to which fish stocks have evolved. Differences in these parameters have long been used to identify separate management stocks assuming that phenotypic variation is due to genotypic and environmental controls. However, few studies have examined the temporal stability of life history parameters, nor the mechanisms by which differences in these parameters between stocks are maintained. We examine the temporal and spatial stability of several life history parameters of Atlantic cod (Gadus morhua), haddock (Melanogrammus aeglefinus), and yellowtail flounder (Limanda ferruginea) in the northwest Atlantic Ocean to assess their utility for stock identification. Although significant temporal differences in vital rates were found within stocks, differences were generally maintained between stocks. Both genetic (biological) and oceanographic (physical) conditions play an integral role in maintaining stock structure. Although, the utility of vital life history parameters for stock identification may decrease with stock complexity and exploitation history, their applicability increases with the number of parameters examined.

Nausea is associated with significant morbidity, and there is a wide range in the propensity of individuals to experience nausea. The neural basis of the heterogeneity in nausea susceptibility is poorly understood. Our previous functional magnetic resonance imaging (fMRI) study in healthy adults showed that a visual motion stimulus caused activation in the right MT+/V5 area, and that increased sensation of nausea due to this stimulus was associated with increased activation in the right anterior insula. For the current study, we hypothesized that individual differences in visual motion-induced nausea are due to microstructural differences in the inferior fronto-occipital fasciculus (IFOF), the white matter tract connecting the right visual motion processing area (MT+/V5) and right anterior insula. To test this hypothesis, we acquired diffusion tensor imaging data from 30 healthy adults who were subsequently dichotomized into high and low nausea susceptibility groups based on the Motion Sickness Susceptibility Scale. We quantified diffusion along the IFOF for each subject based on axial diffusivity (AD); radial diffusivity (RD), mean diffusivity (MD) and fractional anisotropy (FA), and evaluated between-group differences in these diffusion metrics. Subjects with high susceptibility to nausea rated significantly (P < 0.001) higher nausea intensity to visual motion stimuli and had significantly (P < 0.05) lower AD and MD along the right IFOF compared to subjects with low susceptibility to nausea. This result suggests that differences in white matter microstructure within tracts connecting visual motion and nausea-processing brain areas may contribute to nausea susceptibility or may have resulted from an increased history of nausea episodes.