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1,042 results on '"D'ONOFRIO, F."'

58. Retrospective evaluation of patient profiling and effectiveness of apremilast in an Italian multicentric cohort of psoriatic arthritis patients

Author

Favalli, E. G., Conti, F., Selmi, C., Iannone, F., Bucci, R., D Onofrio, F., Carlino, G., Santo, L., Semeraro, A., Zuccaro, C., D Angelo, S., Atzeni, F., Marino, F., Monti, S., Guidelli, G. M., Francesca Romana Spinelli, Biggioggero, M., and Caporali, R.

Subjects
psoriatic arthritis, Treatment Outcome, Italy, Antirheumatic Agents, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Psoriatic, Humans, effectiveness, Female, apemilast, Retrospective Studies, Thalidomide
Abstract

We aimed to evaluate the baseline characteristics, the reasons for prescription, and the effectiveness/safety profile of real-life apremilast for the treatment of psoriatic arthritis (PsA).PsA patients treated with apremilast were retrospectively extracted from an Italian multicentric cohort. Baseline population characteristics and reasons for apremilast prescription were analysed. Clinical response was defined as the proportion of patients achieving Disease Activity in PSoriatic Arthritis (DAPSA) remission/low disease activity (LDA), minimal disease activity (MDA), and very low disease activity (VLDA). Six-month retention rate was computed by the Kaplan-Meier method, with a detailed analysis of reasons for discontinuation. Univariate and multivariate models were developed to examine predictors of clinical response and persistence.The study population included 131 patients mainly with oligoarticular PsA (58%), carrying at least one comorbidity (64.1%, in particular history of malignancies [25.9%] and latent tuberculosis [16.3%]) treated with apremilast as first-line targeted therapy (47.7%) or in biologics failures (52.3%). Contraindication to biologics (60.3%) and lack of poor prognostic factors (27.5%) were the most frequent reason for apremilast prescription. The 6-month retention rate was 72.1%. Inefficacy (n=7), diarrhoea (n=10), nausea (n=3), and headache (n=7) were the most frequent reasons for discontinuation. At 3 months DAPSA LDA/remission, MDA, and VLDA were observed in 40.3, 6.7, and 5.6% of patients, respectively. Female sex was a negative predictor of both retention rate and clinical response.In our real-life analysis apremilast was mainly used in oligoarticular PsA carrying comorbidities leading to contraindications to biologics. Effectiveness and safety profiles were consistent with clinical trials.

Published
2019

59. Occult HBV infection may negatively impact on drug survival in patients with rheumatoid arthritis on treatment with a first biologic drug. An appraisal from the Biologic Apulian Registry (BIOPURE)

Author

Carlino, G., primary, Fornaro, M., additional, Santo, L., additional, Bucci, R., additional, Semeraro, A., additional, Quarta, L., additional, D'Onofrio, F., additional, Marsico, A., additional, Zuccaro, C., additional, Falappone, P.C., additional, Mazzotta, D., additional, Cantatore, F.P., additional, Muratore, M., additional, and Iannone, F., additional

Published
2019
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67. CLINICAL OUTCOMES OF TREATMENT WITH GOLIMUMAB IN SEROPOSITIVE AND SERONEGATIVE RHEUMATOID ARTHRITIS PATIENTS IN REAL-LIFE SETTINGS. DATA FROM ITALIAN REGISTER GISEA

Author

Iannone, F, Caporali, R, Grosso, V, Favalli, Eg, Marchesoni, A, D'Angelo, S, Tramontano, G, Sarzi-Puttini, P, Atzeni, F, Conti, F, Miranda, F, Foti, R, Amato, G, Carletto, A, dal Forno, I, Gremesela, E, Fedele, Al, Cauli, A, Perra, D, Ramonda, R, Lorenzin, M, Sebastiani, M, Cassone, G, Epis, O, Casu, C, Fusaro, E, Priora, M, Govoni, M, Bergossi, F, Cantatore, Fp, D'Onofrio, F, Cantarini, L, Gentileschi, S, Salaffi, F, Di Carlo, M, and Lapadula, G

Published
2018

69. AB0225 Clinical outcomes of treatment with golimumab in seropositive and seronegative rheumatoid arthritis patients in real-life settings. data from italian register gisea

Author

Iannone, F., primary, Caporali, R., additional, Grosso, V., additional, Favalli, E.G., additional, Marchesoni, A., additional, D’Angelo, S., additional, Tramontano, G., additional, Sarzi-Puttini, P., additional, Atzeni, F., additional, Conti, F., additional, Miranda, F., additional, Foti, R., additional, Amato, G., additional, Carletto, A., additional, dal Forno, I., additional, Gremese, E., additional, Fedele, A.L., additional, Cauli, A., additional, Perra, D., additional, Ramonda, R., additional, Lorenzin, M., additional, Sebastiani, M., additional, Cassone, G., additional, Epis, O., additional, Casu, C., additional, Fusaro, E., additional, Priora, M., additional, Govoni, M., additional, Bergossi, F., additional, Cantatore, F.P., additional, D’Onofrio, F., additional, Cantarini, L., additional, Gentileschi, S., additional, Salaffi, F., additional, Di Carlo, M., additional, and Lapadula, G., additional

Published
2018
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70. SAT0327 Baseline characteristics and reasons for apremilast prescription in a large italian cohort of psoriatic arthritis patients

Author

Favalli, E.G., primary, Zuccaro, C., additional, Biggioggero, M., additional, Selmi, C., additional, Bucci, R., additional, D’onofrio, F., additional, Carlino, G., additional, Santo, L., additional, Semeraro, A., additional, Monti, S., additional, Mazzotta, D., additional, Atzeni, F., additional, Caporali, R., additional, and Iannone, F., additional

Published
2018
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71. AB0420 Drug survival on certolizumab and predictors thereof in patients with rheumatoid arthritis, psoriatic arthritis, and axial-spondyloarthritis from the apulian biopure registry

Author

Semeraro, A., primary, Carlino, G., additional, Bucci, R., additional, D’Onofrio, F., additional, Falappone, P.C., additional, Lopriore, S., additional, Marsico, A., additional, Maruotti, N., additional, Mazzotta, D., additional, Muratore, M., additional, Quarta, L., additional, Santo, L., additional, Zuccaro, C., additional, and Iannone, F., additional

Published
2018
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72. Erratum to: Early (≤1-h) vs. late (>1-h) administration of frovatriptan plus dexketoprofen combination vs. frovatriptan monotherapy in the acute treatment of migraine attacks with or without aura: a post hoc analysis of a double-blind, randomized, parallel group study

Author

Allais G, Bussone G, Tullo V, Cortelli P, Valguarnera F, Barbanti P, Sette G, Frediani F, D'Arrigo G, d'Onofrio F, Curone M, Colombo B, Omboni S, Benedetto C., COMI , GIANCARLO, Allais, G, Bussone, G, Tullo, V, Cortelli, P, Valguarnera, F, Barbanti, P, Sette, G, Frediani, F, D'Arrigo, G, D'Onofrio, F, Comi, Giancarlo, Curone, M, Colombo, B, Omboni, S, and Benedetto, C.

Published
2015

73. Vertical eye movements during horizontal head impulse test: a new clinical sign of superior vestibular neuritis

Author

D'ONOFRIO, F.

Subjects
Male, Selective superior semicircular canal paresis, Vertical catch-up saccade, Eye Movements, High-speed video head impulse test, Superior vestibular neuritis, Middle Aged, Vestibology, otorhinolaryngologic diseases, Humans, Female, sense organs, Head Impulse Test, Vestibular Neuronitis
Abstract

In some patients suffering from acute unilateral peripheral vestibular deficit, the head impulse test performed towards the affected side reveals the typical catch-up saccade in the horizontal plane, and an oblique, mostly vertical, upward catch-up saccade after the rotation of the head towards the healthy side. Three cases are reported herein, which have been studied using slow motion video analysis of the eye movements captured by a high-speed webcam (90 fps). The clinical evidence is discussed and a pathophysiological explanation is proposed, consisting in a selective hypofunction of the superior semicircular canal during superior vestibular neuritis.In alcuni pazienti affetti da deficit vestibolare periferico acuto, il Test Impulsivo Cefalico (HIT) eseguito verso il lato malato evidenzia un tipico saccadico di rifissazione sul piano orizzontale, mentre, quando eseguito verso il lato sano, provoca un saccadico obliquo, in maggior misura verticale, verso l'alto. Sono stati studiati tre pazienti in cui il movimento oculare è stato registrato con webcam ad alta frequenza di campionamento (90 fps) ed analizzato al rallentatore. Sono esposte e discusse le evidenze cliniche e ne viene proposta una interpretazione fisiopatologica consistente nella ipofunzione selettiva del canale semicircolare superiore in corso di neurite vestibolare superiore.

Published
2013

74. SAT0105 Survival in first line of biologic agents in an apulian cohort of rheumatoid arthritis patients with occult hepatitis b virus infection

Author

Carlino, G, primary, Fornaro, M, additional, D'Onofrio, F, additional, Maruotti, N, additional, Semeraro, A, additional, Zuccaro, C, additional, Santo, L, additional, Marsico, A, additional, Bucci, R, additional, Quarta, L, additional, Casilli, O, additional, Falappone, PCF, additional, and Iannone, F, additional

Published
2017
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76. THU0164 Subclinical atherosclerosis and cardiovascular events in italian patients with rheumatoid arthritis: results from multicenter girrcs (gruppo italiano di ricerca in reumatologia clinica e sperimentale) study

Author

Ruscitti, P, primary, Margiotta, DPE, additional, Navarini, L, additional, Macaluso, F, additional, Iacono, D, additional, D'Onofrio, F, additional, Emmi, G, additional, Atzeni, F, additional, Prete, M, additional, Perosa, F, additional, Sarzi-Puttini, P, additional, Emmi, L, additional, Cantatore, FP, additional, Triolo, G, additional, Giacomelli, R, additional, and Valentini, G, additional

Published
2017
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78. Headache, anxiety and depressive disorders: the HADAS study. J Headache Pain

Author

Beghi E, Bussone G, D'Amico D, Cortelli P, Cevoli S, Manzoni GC, Torelli P, Tonini MC, Allais G, D'Onofrio F, Genco S, Moschiano F, Beghi M, Salvi S., DE SIMONE, ROBERTO, Beghi, E, Bussone, G, D'Amico, D, Cortelli, P, Cevoli, S, Manzoni, Gc, Torelli, P, Tonini, Mc, Allais, G, DE SIMONE, Roberto, D'Onofrio, F, Genco, S, Moschiano, F, Beghi, M, and Salvi, S.

Abstract

Headache, anxiety and depressive disorders: the HADAS study J Headache Pain (2010) 11:141–150 Ettore Beghi • Gennaro Bussone • Domenico D’Amico • Pietro Cortelli • Sabina Cevoli • Gian Camillo Manzoni • Paola Torelli • Maria Clara Tonini • Giovanni Allais • Roberto De Simone • Florindo D’Onofrio • Sergio Genco • Franca Moschiano • Massimiliano Beghi • Sara Salvi Abstract The objective of this paper was to assess prevalence and characteristics of anxiety and depression in migraine without aura and tension-type headache, either isolated or in combination. Although the association between headache and psychiatric disorders is undisputed, patients with migraine and/or tension-type headache have been frequently investigated in different settings and using different tests, which prevents meaningful comparisons. Psychiatric comorbidity was tested through structured interview and the MINI inventory in 158 adults with migraine without aura and in 216 persons with tension-type headache or migraine plus tension-type headache. 49 patients reported psychiatric disorders: migraine 10.9%, tension-type headache 12.8%, and migraine plus tensiontype headache 21.4%. The MINI detected a depressive episode in 59.9, 67.0, and 69.6% of cases. Values were 18.4, 19.3, and 18.4% for anxiety, 12.7, 5.5, and 14.2%, for panic disorder and 2.3, 1.1 and 9.4% (p = 0.009) for obsessive–compulsive disorder. Multivariate analysis showed panic disorder prevailing in migraine compared with the other groups (OR 2.9; 95% CI 1.2–7.0). The association was higher (OR 6.3; 95% CI 1.4–28.5) when migraine (with or without tension-type headache) was compared to pure tension-type headache. This also applied to obsessive–compulsive disorder (OR 4.8; 95% CI 1.1– 20.9) in migraine plus tension-type headache. Psychopathology of primary headache can reflect shared risk factors, pathophysiologic mechanisms, and disease burden.

Published
2010

79. Drug outcome survey to evaluate anti-TNF treatment in rheumatoid arthritis: an Italian observational study (the DOSE study)

Author

Anecchino, C, Fanizza, C, Marino, V, Romero, M, DOSE Study Group, Costatini, A, Franzin, Mg, Gallo, G, Lattarulo, M, Marchesoni, A, Mazzone, A., Scarpato, S, Valesini, Guido, Celeste, Mg, Di Muzio, G, Gentile R, Perricone R, Garibaldi, Ao, Battaglia, E, Bonaccorsi, Lm, Rapisarda, A, Juric, P, Malavolta, N, Mulè, R, Puggioli, C, Arduini, E, Ceccarelli, Fulvia, Valesini, G, Bianchi, S, Padovan M, Trotta F, Bazzichi, L, Consensi, A, Dal Canto, L, Doveri, M, Polvani, M., Bello, S, Bonali, C, Intini, S, Faggioli, A, Cesta V, Costantini A, Cavaliere, A, Laurenti, R, Dell'Orso, B, De Simone, M, Meschini, C, Bellantoni, A, Massari, V, Rotunno, L., Ciapetti, A, Gasparini, S, Grassi, W, Lupi, E, Verri, F, Del Pizzo, V, Donadio, D, Ferrucci, Mg, Goglia, C, Racca, A, Stisi, S, Maesano, C., Ferraccioli, G., Jacoboni, Er, Privitera, R, Proli, Em, Galeazzi, M, Menza, L, Misiani, F, Tarantino, A, Capobianco, L, D'Onofrio, F, Stea, S, Silvi, E, and Vitocolonna, E.

Subjects
Adult, Male, Drug Resistance, Severity of Illness Index, Etanercept, Arthritis, Rheumatoid, Disability Evaluation, Sex Factors, Drug Therapy, Rheumatoid, Humans, Prospective Studies, Age Factors, Aged, Drug Monitoring, Drug Therapy, Combination, Female, Italy, Middle Aged, Treatment Outcome, Tumor Necrosis Factor-alpha, Adalimumab, Antirheumatic Agents, Infliximab, Arthritis, Combination
Abstract

The aim of this paper is to analyse the use of anti-TNF drugs in current Italian practice, evaluate clinical responses to treatment, and identify possible predictors of negative response in patients with rheumatoid arthritis (RA).DOSE is a non-interventional, prospective study of patients with active RA treated for the first time with anti-TNF agents in 21 Italian hospitals. Demographic and clinical characteristics of patients, treatments and outcome measures were assessed. Outcome measures used were EULAR response, DAS28 remission and HAQ remission at 12 months. A stepwise logistic regression model was used to study the predictors of non-response.Of 299 RA patients (mean 53.8 ± 12.8 years, 76.1% female), DAS28 was5.1 in 60.5% of patients and HAQ was1 in 65.9%. Etanercept was the most prescribed anti-TNF. DMARDs were used in 77.6% of patients (methotrexate in 59.2%). Significant improvements in clinical and laboratory parameters were observed at 12 months. The proportion of patients classed as non-responders remained high, and varied according to assessment criteria. The main predictors independently and significantly associated with a high risk of non-response were: age and female gender for all outcome criteria; high DAS28 value for disease remission; and HAQ1 for disability remission.In Italian anti-TNF treatment for RA, age, gender, and high values of both disease activity and disability were predictors of non-response to first-line therapy with anti-TNF drugs. Future studies should consider optimal second-line therapies for RA patients who do not achieve remission to their first anti-TNF treatment.

Published
2014

80. SAT0489 Biologic Therapies and Infections in The Daily Practice: A Study on Historical Cohort from 3 Italian Rheumatologic Units

Author

Cipriani, P., primary, Berardicurti, O., additional, Masedu, F., additional, D'Onofrio, F., additional, Navarini, L., additional, Ruscitti, P., additional, Maruotti, N., additional, Margiotta, D.P.E., additional, Liakouli, V., additional, Di Benedetto, P., additional, Carubbi, F., additional, Valenti, M., additional, Cantatore, F.P., additional, Afeltra, A., additional, and Giacomelli, R., additional

Published
2016
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91. Knowing to transform : three ways for agricultural economists to observe Italy 1900-1940

Author

D'Onofrio, F., UU LEG Research UUSE Multidisciplinary Economics, Economie van de welvaartsstaat, UU LEG Research USE Tjalling C. Koopmans Institute, Plantenga, Janneke, Morgan, M.S., Maas, Harro, and University Utrecht

Abstract

Knowing to transform describes how Italian agricultural economists collected information about the economy of Italy, how these practices of observation contributed to the development of the theoretical tenets of agricultural economists, and in particular to the analysis of family farms. Finally, this work discusses how observation entred the political debate on agricultural policies before and during the Fascist regime. This work introduces the concept of "stakeholder statistics", and stresses the two way relation between the observer and the observed that in the context of this project can be considered in terms of coproduction of observational knowledge.

Published
2013

95. Effetto della Metformina sul food-intake in soggetti obesi

Author

RIZZO, Maria Rosaria, Manzella D, Petrella G, Saccomanno F, Turano F, PAOLISSO, Giuseppe, GIUGLIANO, Dario, D’Onofrio F., Rizzo, Maria Rosaria, Manzella, D, Petrella, G, Saccomanno, F, Turano, F, Paolisso, Giuseppe, Giugliano, Dario, and D’Onofrio, F.

Published
1998

98. Età geriatrica ed insulino-resistenza: quale ruolo per DHEA solfato?

Author

Tagliamonte MR, Turano F, Saccomanno F, Manzella D, Carella C, PAOLISSO, Giuseppe, Varricchio M, D’Onofrio F., RIZZO, Maria Rosaria, Tagliamonte, Mr, Rizzo, Maria Rosaria, Turano, F, Saccomanno, F, Manzella, D, Carella, C, Paolisso, Giuseppe, Varricchio, M, and D’Onofrio, F.

Published
1997

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