347 results on '"Czekalski, S."'
Search Results
52. Pharmacokinetic parameters of thiamazole in hyperthyroid patients responding rapidly and slowly to the treatment
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Syrenicz, A., barbara gawronska-szklarz, Wojcicki, J., and Czekalski, S.
53. Arg 16Gly polymorphism of beta2-adrenoceptor gene and salt sensitivity of blood pressure in Polish hypertensive
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Andrzej Ciechanowicz, Widecka, K., Adler, G., Cyryowski, L., Czekalski, S., and Ciechanowicz, A.
54. Phenazone pharmacokinetics in patients quickly and slowly attaining euthyreosis after the treatment with methimazole
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Wojcicki, J., Gornik, W., Syrenicz, A., barbara gawronska-szklarz, and Czekalski, S.
55. Influence of physical activity on vertebral deformity in men and women: Results from the European Vertebral Osteoporosis Study
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Silman, A. J., Terence O'Neill, Cooper, C., Kanis, J., Felsenberg, D., Abendroth, K., Agnusdei, D., Antoniou, A., Aroso, A., Banzer, D., Benevolenskaya, L. I., Bergmann, K., Bhalla, A. K., Andia, J. B. C., Czekalski, S., Delmas, P. D., Dequeker, J., Diaz Curiel, M., Diaz Lopez, J. B., Dilsen, G., Eastell, R., Falch, J. A., Felsch, B., Franke, J., Gennari, C., Geusens, P., Havelka, S., Hofman, A., Hoszowski, K., Jajic, I., Janott, J., Johnell, O., Kalidis, L., Kirschner, S., Kiss, C., Krusekemper, G., Lauermann, T., Letkovska, A., Vaz, A. L., Lorenc, R. S., Lyritis, G., Marchand, F., Marsden, D., Masaryk, P., Matthis, C., Mews, J., Meyer, H. E., Miazgowski, T., Mikhailov, E. E., Diaz, M. N., Nilsson, B., Ortoloni, S., Petta, G., Pols, H. A. P., Poor, G., Rapado, A., Raptou, P., Raspe, H., Reeve, J., Reid, D. M., Reisinger, W., Ring, F., Escofet, D. R., Martin, M. R., Schatz, H., Sheidt-Nave, C., Sosa, M., Todd, C., Vavrincova, P., Varlow, J., Weber, K., Woolf, A. D., Wieland, E., Williams, R., and Ziegler, R.
56. Chronic renal insufficiency (part II)--current methods of slowing down disease progression,Przewlekła niewydolność nerek (Cześć II)--Aktualne metody hamowania progresji
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Czekalski, S., Oko, A., Pawlaczyk, K., and Ilona Idasiak-Piechocka
57. Post-transplant nephropathy and arterial hypertension,Nadciśnienie tetnicze a przewlekła nefropatia potransplantacyjna
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Oko, A., Ilona Idasiak-Piechocka, and Czekalski, S.
58. Cardiovascular system in patients in different stages of chronic kidney disease,Stan układu sercowo-naczyniowego u pacjentów w różnych stadiach przewlekłej choroby nerek
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Strózecki, P., Kozłowski, M., Grajewska, M., Kurowski, R., Stefańska, A., Odrowa̧z-Sypniewska, G., Serafin, Z., Lasek, W., Nartowicz, E., Jacek Kubica, Manitius, J., Czekalski, S., Pupek-Musialik, D., and Myśliwiec, M.
59. Expert panel position statement on imaging diagnostics and indications for percutaneous angioplasty for renal artery stenosis in hypertensive patients, adopted by Polish Society of Hypertension and Polish Society of Nephrology,Stanowisko grupy ekspertów dotycza̧ce diagnostyki obrazowej i wskazań do wykonywania zabiegów przezskórnej angioplastyki zwȩżenia tȩtnicy nerkowej u chorych z nadciśnieniem tȩtniczym: Przyjȩte przez Polskie Towarzystwo Nadciśnienia Tȩtniczego, Polskie Towarzystwo Nefrologiczne
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Witkowski, A., Wiȩcek, A., Januszewicz, A., Andziak, P., Buszman, P., Cieszanowski, A., Czekalski, S., Gaciong, Z., Robert Gil, Głuszek, J., Januszewicz, M., Januszewicz, W., Juszkat, R., Kabat, M., Kabłak-Ziembicka, A., Ka̧dziela, J., Kleinork, A., Lekston, A., Lesiak, M., Michałowska, I., Posadzy-Małaczyńska, A., Prejbisz, A., Przewłocki, T., Rowiński, O., Rynkiewicz, A., Szczerbo-Trojanowska, M., and Tykarski, A.
60. The evaluation of bone mineral density and selected markers of bone turnover in patients with insulin dependent diabetes mellitus,Ocena gestości mineralnej kości i wybranych markerów przebudowy kości u chorych na cukrzyce insulinozalezna
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Miazgowski, T., Elżbieta Andrysiak-Mamos, Pynka, S., Gulińska, M., and Czekalski, S.
61. Inherited reduced number of nephrons versus primary arterial hypertension,Wrodzona zmniejszona liczba nefronów a pierwotne nadcisnienie t¿tnicze
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Czekalski, S., Oko, A., Pawlaczyk, K., Myśliwiec, M., Ksia̧zek, A., Gellert, R., Rowińska, D., Ryszard Grenda, and Manitius, J.
62. Comparison of thiamazole pharmacokinetics in healthy individuals and patients with hyperthyroidism,Porównanie farmakokinetyki tiamazolu u osób zdrowych i chorych na nadczynność tarczycy
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Anhelli Syrenicz, Gawrońska-Szklarz, B., Wójcicki, J., and Czekalski, S.
63. [Analysis of polymorphisms Sma (Hpa II) and Sca I gene precursors of atrial natriuretic peptide (ANP) in patients with essential hypertension]
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Widecka, K., Andrzej Ciechanowicz, Adler, G., Szychot, E., Wodecki, M., and Czekalski, S.
64. Wegener's granulomatosis associated with rapidly progressive glomerulonephritis,Przypadek gwałtownie postȩpuja̧cego kłȩbuszkowego zapalenia nerek w przebiegu choroby Wegenera
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Ilona Idasiak-Piechocka, Oko, A., Łochyńska, K., Woźniak, A., and Czekalski, S.
65. Pathomechanism of hyperlipoproteinemia in chronic renal failure,Patomechanizm hiperlipoproteinemii w przewlekłej niewydolności nerek
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Rutkowski, B., Łososowska, R., Król, E., Kisielnicka, E., Zbigniew Zdrojewski, Szołkiewicz, M., Niewȩglowski, T., Chmielewski, M., Sucajtys, E., Świerczyński, J., Korczyńska, J., Stelmańska, E., Goyke, E., Bogusławski, W., Czekalski, S., Klinger, M., and Manitius, J.
66. [Plasma prekallikrein in chronic liver diseases]
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Ciechanowicz A, Miks B, Jerzy Kawiak, Ciechanowski K, Ryszkiewicz D, Długosz A, Syczewska-Wawrzynowicz M, Marzecka J, and Czekalski S
- Subjects
Adult ,Liver Cirrhosis ,Male ,Carcinoma, Hepatocellular ,Liver Diseases ,Liver Neoplasms ,Prekallikrein ,Middle Aged ,Hepatitis ,Chronic Disease ,Humans ,Female ,Biomarkers ,Aged - Abstract
Plasma prekallikrein (PPK) is a single-chain glycoprotein synthesized in the liver. The aim of our study was to evaluate a plasma prekallikrein as the marker reflecting liver protein synthesis in patients with chronic liver diseases. PPK levels have been measured by own modification of amidolytic micro-assay in 43 patients with chronic liver diseases and 37 healthy volunteers as control group. As compared to control group, PPK level was significantly decreased in patients with chronic active hepatitis and with decompensated liver cirrhosis and significantly increased in patients with liver cirrhosis complicated by hepatocellular carcinoma. There was no difference in plasma prekallikrein between patients with compensated liver cirrhosis and controls. The results suggest that PPK might be a useful index for the assessment of residual functional liver mass in patients with chronic liver diseases.
67. Indications for imaging,Stanowisko grupy ekspertów dotycza̧ce diagnostyki obrazowej i wskazań do wykonywania zabiegów przezskórnej angioplastyki zwȩzenia tȩtnicy nerkowej u chorych z nadciśnieniem tȩtniczym. Przyjȩte przez Polskie Towarzystwo Nadciśnienia Tȩtniczego, Polskie Towarzystwo Nefrologiczne i Polskie Towarzystwo Kardiologiczne
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Witkowski, A., Wiȩcek, A., Januszewicz, A., Andziak, P., Paweł Buszman, Cieszanowski, A., Czekalski, S., Gaciong, Z., Gil, R., Głuszek, J., Januszewicz, M., Januszewicz, W., Juszkat, R., Kabat, M., Kabłak-Ziembicka, A., Ka̧dziela, J., Kleinork, A., Lekston, A., Lesiak, M., Michałowska, I., Posadzy-Małaczyńska, A., Prejbisz, A., Przewłocki, T., Rowiński, O., Rynkiewicz, A., Szczerbo-Trojanowska, M., and Tykarski, A.
68. The DD genotype of the ACE gene is associated with elevated albuminuria in salt-sensitive essential hypertension
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Krystyna Widecka, Ciechanowicz, A., Adler, G., and Czekalski, S.
69. Pregnancy in diabetic woman with coexisting hypothyroidism, coronary artery disease and with early onset nephrotic syndrome - a case report
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Wender-Ozegowska, E., Zawiejska, A., Wanic-Kossowska, M., Stefan Ożegowski, Brazert, J., and Czekalski, S.
70. Guidelines for diagnosis and treatment of primary aldosteronism,Zalecenia dotycza̧ce diagnostyki i leczenia pierwotnego hiperaldosteronizmu
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Januszewicz, A., Kokot, F., Widecka, K., Wiȩcek, A., Czekalski, S., Cieszanowski, A., Jerzy Chudek, Dobrucki, T., Florczak, E., Gaciong, Z., Głuszek, J., Grodzicki, T., Janaszek-Sitkowska, H., Januszewicz, M., Januszewicz, W., Kabat, M., Kasperlik-Załuska, A., Królicki, L., Litwin, M., Makowiecka-Cieśla, M., Narkiewicz, K., Otto, M., Prejbisz, A., Romer, T., Sznajderman, M., Tykarski, A., Walecki, J. M., Wasiutyński, A., and Zgliczyński, W.
71. Effect of hypertension on function of the transplanted kidney--3 years follow-up,Wpływ nadciśnienia tetniczego na czynność przeszczepionej nerki w trzyletniej obserwacji
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Oko, A., Olejnik, A., Ilona Idasiak-Piechocka, Włodarczyk, Z., Głyda, M., and Czekalski, S.
72. ScaI polymorphism of the ANF gene is associated with higher ANF plasma levels in salt-sensitive essential hypertension
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Widecka, K., Andrzej Ciechanowicz, Adler, G., and Czekalski, S.
73. Quality of life and therapy in the elderly patients on chronic peritoneal dialysis,Jakość terapii i jakość życia u chorych w podeszłym wieku leczonych dializa̧ otrzewnowa̧
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Lichodziejewska-Niemierko, M., Bobeł-Olchowik, B., Mikolaj Majkowicz, Afeltowicz, Z., Liberek, T., Rutkowski, B., Wańkowicz, Z., Ksia̧zek, A., Myśliwiec, Z., Czekalski, S., Manitius, J., Grzegorzewska, A., Klinger, M., and Dȩbska-Ślizień, A.
74. [Thyroid nodules--diagnostic and therapeutic problems]
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Syrenicz, A., Widecka, K., Kosinski, B., Maria Listewnik, and Czekalski, S.
75. Prolongation of rat kidney graft survival after inoculation of allogeneic spleen cells: the effect of various routes of cell transfer
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Oko, A., Ilona Idasiak-Piechocka, Pawlaczyk, K., Wruk, M., Pawliczak, E., and Czekalski, S.
76. Chronic renal insufficiency (part I)--diagnosis,Przewlekła niewydolność nerek (Cześć I)--Diagnostyka
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Czekalski, S., Oko, A., Pawlaczyk, K., and Ilona Idasiak-Piechocka
77. Intrinsic properties of the nonpeptide angiotensin II antagonist losartan in glomeruli and mesangial cells at high concentrations
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Chansel D, Badre L, Czekalski S, sophie VANDERMEERSCH, Cambar J, and Ardaillou R
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Male ,Dose-Response Relationship, Drug ,Cell Survival ,Angiotensin II ,Biphenyl Compounds ,Kidney Glomerulus ,Imidazoles ,Tetrazoles ,Losartan ,Glomerular Mesangium ,Rats ,Rats, Sprague-Dawley ,Animals ,Humans ,Vasoconstrictor Agents ,Calcium ,Antihypertensive Agents ,Cells, Cultured - Abstract
Intrinsic activities of the nonpeptide angiotensin II antagonist losartan were examined in a number of in vitro assays. Losartan produced contraction of rat isolated glomeruli at 100 mumol/l and of human mesangial cells at 1 to 100 mumol/l. Cell surface reduction was associated with disorganization of the alpha actin microfilament bundles. Losartan also stimulated cytosolic calcium concentration in cultured human mesangial cells at high concentrations (10-100 mumol/l). Losartan-dependent cytosolic free calcium concentration increase was not affected by nicardipine or 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxy-benzoate hydrochloride, whereas it was abolished in a calcium-free medium. There was a marked homologous desensitization response to losartan which was also obtained after pretreatment by EXP 3174 (2-n-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]imidazole-5-carboxylic acid), the metabolite of losartan. The search for other agonistic effects of losartan in human mesangial cells including inositoltriphosphate formation, prostaglandin E2 production, [3H]leucine or [3H]thymidine incorporation was negative. Losartan and EXP 3174 were not toxic for human mesangial cells at the concentrations studied as judged by the absence of release of lactate dehydrogenase and the normal uptake of neutral red. These studies demonstrate that losartan exhibits glomerular effects in vitro only at high concentrations. Their relevance to in vivo situations is still questionable.
78. Comparative study of two immunosuppressive treatment methods in patients with focal segmental glomerulosclerosis,Porownanie dwoch metod leczenia immunosupresyjnego u chorych na ogniskowa segmentalna sklerotyzacje klebuszkow nerkowych
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Oko, A., Ilona Idasiak-Piechocka, Olejnik, A., Woźniak, A., Łochyńska, K., Krzymański, M., Salwa-Zurawska, W., and Czekalski, S.
79. Adaptation to high salt diet in sodium sensitive and non-sodium sensitive hypertensive patients
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Widecka, K., Andrzej Ciechanowicz, and Czekalski, S.
80. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Ad Darts Memo, Morris For The Collaboration, Juhl, C., Porksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th, Muller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Bjorn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H-M, Oksanen, L., Tuomainen, T-P, Kontula, K., Salonen, J. T., Dekker, J. M., Boks, P., Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., Macalpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M. Jr, Kozakova, H., Kaas, A., Kofronova, O., Tlaskalova-Hogenova, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sorensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Hasko, G., Szabo, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H-H, Genediab, Study Group, Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabak, A. Gy, Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Canton, A., Burgos, R., Hernandez, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simo, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., Mcdermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y-S, Sternesjo, J., Sandler, S., Chen, M-C, Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Breant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessieres-Lacombe, S., Gedec, Study Group, Tauber, J-P, Home, P. D., Lindholm, A., Riis, A., European Insulin Aspart Study Group, Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Us Dm, Study Group Of Insulin Glargine In Type, Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Hvidore Study group on Childhood Diabetes, Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Ukpds, Group, Steiner, G., Dais, Project Group, Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Verges, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph, Benko, B., Ljubic, S., Turk, Z., Granic, M., Marz, W., Wollschlager, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O Rahilly, S., Hattersley, A. T., Mccarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Siman, C., Wisse, Bert, Gittenberger-De Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ozegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rosc, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Skrha, J., Kvasnicka, J., Kalvodova, B., Hilgertova, J., Schatteman, K., Goossens, F., Scharpe, S., Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Haring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., Mckinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnas, A. M., Andersen, N. Aa, Osterhoff, M., Mohlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Furnsinn, C., Nowotny, P., Waldhausl, W., Roden, M., Neeft, M., Meijer, A. J., Bavenholm, P., Pigon, J., Efendic, S., Kastenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovska, A., Kasalicky, P., Hosova, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefebvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valero, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., Galan, B., Netea, M. G., Hancu, N., Smits, P., Meer, J. W. M., Osterbye, T., Jorgensen, K. H., Tranum-Jensen, J., Fredman, P., Hoy, M., Bokvist, K., Olsen, H. L., Horn, T., Gromada, J., Laub, R., Lohmann, T., Hahn, H. J., Adler, T., Emmrich, F., Rabuazzo, A. M., Lupi, R., Dotta, F., Patane, G., Marselli, L., Realacci, M., Piro, S., Del Guerra, S., Santangelo, C., Navalesi, R., Purrello, F., Marchetti, P., Vos, P., Visser, L., Haan, B. J., Klok, P., Schilfgaarde, R., Poppema, S., Juang, J-H, Kuo, C-H, Hsu, B. R-S, Nacher, V., Perez, M., Biarnes, M., Raurell, M., Soler, J., Montanya, E., Ritzel, R., Maubach, J., Busing, M., Becker, T., Klempnauer, J., Hucking, K., Schmiegel, W. H., Nauck, M. A., Boucek, P., Saudek, F., Adamec, M., Kozitarova, R., Jedinakova, T., Vlasakova, Z., Bartos, V., Maffi, P., Bertuzzi, F., Aldrighetti, L., Taglietti, M. V., Castelnuovo, A., Pozza, G., Di Carlo, V., Secchi, A., Renier, G., Mamputu, J-C, Gillespie, J. S., Mcmaster, D., Mercer, C., Trimble, E. R., Lecomte, M., Vericel, E., Paget, C., Ruggiero, D., Lagarde, M., Wiernsperger, N., Pricci, F., Leto, G., Amadio, L., Cordone, S., Iacobini, C., Catalano, S., Violi, F., Rotella, C. M., Pugliese, G., Zicari, A., Gradini, R., Sale, P., Pala, L., Cresci, B., Giannini, S., Manuelli, C., Dahlfors, G., Arnqvist, H. J., Gonelle-Gispert, C., Halnan, P. A., Sadoul, K., Wolter, S., Lang, J., Niwa, T., Yu, W., Hidaka, H., Senda, T., Niki, I., Fukasawa, T., Renstrom, E., Barg, S., Seward, E., Rorsman, P., Rutter, G. A., Molinete, M., Lilla, V., Ravazzola, M., Halban, P. A., Efanov, A. M., Bertorello, A. M., Zaitsev, S. V., Zwiller, J., Berggren, P-O, Msengul, A., Salman, F., Sargrn, M., Ozer, E., Karsidaǧ, K., Salman, S., Gedik, S., Satman, I., Dinccaǧ, N., Yilmaz, M. T., Lloyd, A., Hopkinson, P. K., Testa, M. A., Blonde, L., Turner, R. R., Hayes, J., Simonson, D. C., Ven, N. C. W., Lubach, C. H. C., Snoek, F. J., Mollema, E. D., Ploeg, H. M., Danne, T., Hoey, H., Mcgee, H., Fitzgerald, H., Lernmark, B., Thernlund, G., Fredin, K., Hagglof, B., Lugari, R., Anna, C., Ugolotti, D., Dei Cas, A., Barilli, A. L., Sard, L., Marani, B., Iotti, M., Zandomeneghi, R., Gnudi, A., Kjems, L. L., Volund, Aa, Toft-Nielsen, M., Damholt, M. B., Hilsted, L., Hughes, T. E., Krarup, T., Holst, J. J., Young, A., Gottlieb, A., Fineman, M., Kolterman, O., Cancelas, J., Garcia-Martinez, J. A., Villanueva-Penacarrillo, M. L., Valverde, I., Malaisse, W. J., Filipsson, K., Ahren, B., Balkan, B., Kwasnik, L., Battle, B., Li, X., Egan, J. M., Clocquet, A. R., Elahi, D., Petrella, E., Pricket, K., Petersen, K. F., Sullivan, J. T., Amatruda, J. M., Livingston, J. N., Shulman, G. I., Freyse, E-J, Knospe, S., Glund, K., Demuth, H-U, Walker, D., Malik, R. 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D., Schick, F., Diraison, F., Moulin, P., Beylot, M., Thams, P., Capito, K., Eliasson, Lena, Barg, Sebastian, Gopel, Sven, Kanno, Takahiro, Renstrom, Erik, Meda, P., Charollais, A., Gjnovci, A., Calabrese, A., Wonkam, A., Caton, D., Wisznievski, L., Serre, V., Cogne, F., Bauquis, J., Bosco, D., Huarte, J., Herrera, P., Gotfredsen, C. F., Vessby, B., Kanwu, Study Group, Manuel Y Keenoy, B., Engelen, W., Vertommen, J., Schrans, S., Louheranta, A., Lindstrom, J., Tuomilehto, J., Finnish Diabetes Prevention Study Group, Segal, K. R., Heymsfield, S., Hauptman, J., Boldrin, M., Lucas, C., Pandolfi, A., Cetrullo, D., Polishchuck, R., Alberta, M., Pellegrini, G., Calafiore, A., Vitacolonna, E., Capani, F., Consoli, A., Halleux, C. M., Gillot, E. F., Brichard, S. M., Planken, M., Corthouts, B., Peiffer, F., Scholten, D., Walke, M., Assert, R., Pirags, V., Pedula, K. L., Hillier, T. A., Brown, J. B., Eurodiab, Prospective Complications Study Group, Santini, S. A., Marra, G., Cotroneo, P., Manto, A., Di Leo, M. A. S., Di Gregorio, S., Tordi, A., Pitocco, D., Ruotolo, V., Ghirlanda, G., Temelkova-Kurktschiev, T., Schaper, F., Koehler, C., Henkel, E., Hanefeld, M., Mancini, L., Citterio, F., Cotroneo, A., Ceroone, S., Castagneto, M., Rajbhandari, S. M., Dent, M. T., Plater, M. E., Harris, N. D., Tesfaye, S., Ward, J. D., Dupuy, O., Mayaudon, H., Lecoules, S., Bauduceau, B., Palou, M., Farret, O., Molinie, C., Antonelli-Incalzi, R., Fuso, L., Giordano, A., Calcagni, M. L., Todaro, L., Basso, S., Tramaglino, L. M., Troncone, L., Pistelli, R., Guillot, R., Bringuier, A., Porokhov, B., Guillausseau, P. J., Feldmann, G., Zivanic, S., Cizmic, M., Dragojevic, R., Vanovic, M., Borghouts, L. B., Kranenburg, G. P. J., Schaart, G., Keizer, H. A., Niess, A. M., Dickuth, H. H., Lutz, O., Barbe, P., Calazel-Fournier, C., Hernandez, G., Saint-Martin, F., Galitzky, J., Goncalves, A. A., Da Silva, E. C., Brito, I. J. L., Da Silva, C. A., Lawrence, N. J., Kousta, E., Mulnier, H., Penny, A., Millauer, B., Johnston, D. G., Robinson, S., Perriello, G., Pimenta, W., Pampanelli, S., Lucidi, P., Lepore, M., Porcellati, F., Cordoni, M. C., Feo, P., Bolli, G. B., Sjostrand, M., Holmang, A., Lonnroth, P., Hauer, B., Grauer, P., Artzner, S., Lang, R., Stumvoll, M., Monti, L. D., Piatti, P. M., Gemone, F., Valsecchi, G., Magni, M., Barbieri, E., Setola, E., Sandoli, E. P., Galli-Kienle, M., Pontiroli, A. E., Nichols, Gregory A., Brown, Jonathan B., Salzsieder, E., Boltz, H., Ramirez, J. C., Rutscher, A., Fischer, U., Koenig, Ch, Friske, M., Schramm, W., Landgraf, R., Bachmann, W., Bangemann, M., Groeneveld, G., Edvell, Anders, Lindstrom, Per, Tsiotra, P., Koukourava, A., Raptis, S. A., Tsigos, C., Boutou, E., Triandaffilopoulou, A., Egido, E. M., Rodriguez-Gallardo, J., Gutierrez, E., Garcia, P., Silvestre, R. A., Marco, J., Khan, Akhtar, Ling, Zong-Chao, Ahren, Bo, Efendic, Suad, Bunting, C., Du, X., Zhi Sui, G., Rosen, P., Koschinsky, T., Kearney, T. M., Sharp, P. S., Lapolla, A., Fedele, D., Martano, L., Garbeglio, M., Seraglia, R., Favretto, D., Traldi, P., Meerwaldt, R., Smit, A. J., Links, Th P., V Roon, A. M., Graaf, R., Gans, R. O. B., Deyneli, O., Ersoz, H. O., Gogas, D., Fak, A. S., Akalin, S., Veglio, M., Sivieri, R., Chinaglia, A., Scaglione, L., Neuropathy Study Group of the Italian Society of the Study of Diabetes, Le, T., Wong, N., Detrano, R., Charles, M. A., Colhoun, H. M., Francis, D. P., Rubens, M., Underwood, S. R., Fuller, J. H., Knudsen, E., Sato, A., Nielsen, F. S., Bonora, E., Kiechl, S., Willeit, J., Oberhollenzer, F., Egger, G., Bonadonna, R., Muggeo, M., Festa, A., D Agostino, R. Jr, Howard, G., Mykkanen, L., Tracy, R. P., Haffner, S. M., Poulsen, P., Vach, K., European Group for the Study of Insulin Resistance (EGIR), Ijzerman, R. G., Bakker, S. J. L., Truster, J., Crowther, N. J., Cameron, N., Gray, I. P., Chaillous, L., Carel, J. C., Thivolet, C., Boitard, C., Charbonnel, B., Sai, P., Study Group, D. I. O. R., Decochez, K., Keymeulen, B., Somers, G., Dorchy, H., Rottiers, R., Winnock, F., Ver Elst, K., Weets, I., Pipeleers, D., Gorus, F., Seebaum, S., Schumm-Draeger, P-M, Petzoldt, R., Federlin, K., Bonnevie-Nielsen, V., Martensen, P. M., Justesen, J., Worsaa, A., Karlsson, Maria, Sederholm, Sofia, Ludvigsson, Johnny, Belicar, P., Dale, C., Vague, Ph, Alessis, C., Lassmann-Vague, V., Bode, B. W., Gross, T. M., Ghegan, M., Steed, R. D., Davidson, P. C., Ordonez, A., Rubio, J. L., Sulleiro, J. M., Buendia, J. P., Zamora, J., Castillo, M., Schaupp, L., Ellmerer, M., Brunner, G. A., Sendlhofer, G., Schlack, Ch, Skrabal, F., Wach, P., Pieber, T. R., Heinemann, L., Kramer, U., Klotzer, H. M., Hermann, M., Non-Invasive Task Force, Cosgrove, K. E., Chapman, J. C., Shepherd, R. M., Mcintyre, S., Butler, P. C., Dunne, M. J., Brekardin, E., Dorschner, H., Schwanstecher, C., Schwanstecher, M., Uhde, I., Emmanouilidou, E., Teschemacher, A. G., Pouli, A. E., Gylfe, E., Tengholm, A., Hellman, B., Perfetti, R., Aggarwal, S., Muller, Gunter, Welte, Stefan, Wied, Susanne, Valverde, A. M., Mur, C., Kahn, C. R., Benito, M., Rondinone, C. M., Peterson, T., Laviola, L., Belsanti, G., Logoluso, F., Napoli, R., Davalli, A. M., Weir, G. C., Giorgino, R., Giorgino, F., Flesch, S., Hompesch, B., Rave, K., Susanto, F., Kuhn-Velten, W. N., Heise, T., Rendell, M., Dole, J., Rosiglitazone Study Group, Esper, R. J., Stein, E., Lemme, L., Cerivastatin/Bezafibrate Latin America Study Group, Rubinstein, A., Maritz, F. J., Soule, S., Market, A., Chajek-Shaul, T., Maislos, M., Tal, S., Stolero, D., Hidm, Investigators, Josefsen, K., Beckmann, H., Petersen, C., Ekman, R., Efanova, I., Zaitsev, S., Berggren, P. O., Birkenbach, M., Holl, R. W., Rosenbauer, J., Grabert, M., German Working Group on Quality Control, Icks, A., Schwab, O., Reile, K., German Pediat. Working Group, Janssen, M. M. J., Jongh, R. T., Casteleijn, S., Masurel, N., Hoogma, R. P. L. M., Santeusanio, F., Brunetti, P., Fanelli, C. G., Laureti, S., Bartocci, L., Maran, A., Crepaldi, C., Trupiani, S., Macdonald, I. A., Avogaro, A., Bouman, S. D., Keitz, M., Bruggink, J. E., Scheurink, A. J. W., Strubbe, J. H., Steffens, A. B., Ferguson, S. C., Mccrimmon, R. J., Perros, P., Best, J. J. K., Deary, I. J., Frier, B. M., Robinson, R. T. C. E., Ireland, N. H., Bedford, C., Fairclough, E., Hudson, S., Heller, S. R., Borch-Johnsen, K., Berger, M., Overmann, H., Bender, R., Blank, M., Sawicki, P., Jorgens, V., Muhlhauser, I., Nosadini, R., Sailer, A., Dalla Vestra, M., Brocco, E., Piarulli, F., Frigato, F., Sambataro, M., Velussi, M., Baggio, B., Fioretto, P., Jager, A., Hinsbergh, V. W. M., Kostense, P. 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L., Vigili Kreutzenberg, S., Marchetto, S., Calo, L., Wascher, T. C., Wolkart, G., Brunner, F., Tripathy, Devjit, Carlsson, Martin, Isomaa, Bo, Tuomi, Tiinamaija, Groop, Leif, Stoffers, D. A., Muller, D. C., Wideman, L., Chin, G. A., Clarke, W. L., Hanks, J. B., Habener, J. F., Guazzarotti, L., Toffolo, G., Clementi, L., Vespasiani, G., Cobelli, C., Clauin, S., Bellanne-Chantelot, C., Bartolotta, E., Gautier, J-F, Wilson, C., Weyer, C., Mort, D., Knowler, W. C., Polonsky, K., Bogardus, C., Pratley, R. E., Veldhuis, J. D., Polonsky, K. S., Byrne, M. M., Brandt, A., Arnold, R., Katschinski, M., Goke, B., Hardt, E., Fritsche, A., Stefan, N., Schutzenauer, S., Luddeke, H. J., Renner, R., Hepp, K. D., Shnawa, N., Krugluger, W., Hopmeier, P., Schernthaner, G., Kautzky-Willer, A., Prager, R., Fallucca, F., Sabbatini, A., Sciullo, E., Torresi, P., Mazziotti, F., Maroccia, E., Napoli, A., Buongiorno, A., Deberg, M., Dozio, N., Castiglioni, M. 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F., Motala, A. A., Omar, M. A. K., Tzaneva, V., Iotova, V., Jaeger, C., Hatziagelaki, E., Stroedter, A., Becker, F., Bretzel, R. G., Strebelow, M., Schlosser, M., Ziegler, B., Ziegler, M., Wassmuth, R., Ostrauskas, R., Zalinkevicius, R., Norkus, A., Lithuanian Collaborative Group for the Epidemiology of Diabetes, Jarosz-Chobot, P., Otto-Buczkowska, E., Koehler, B., Maklakiewicz, E., Green, A., Ionescu-Tirgoviste, C., Serban, V., Guja, C., Mota, M., Creteanu, G., Calin, A., Morosanu, M., Ferariu, I., Halmagy, I., Cristescu, I., Strugariu, M., Minescu, A., Barbul, R., Visalli, N., Sabastiani, L., Adorisio, E., Cassone Faldetta, M. R., Multari, G., Casu, A., Songini, M., Pozzilli, P., Imdiab, Study Group, Muntoni, Sa, Waananen, S., Law, G., Muntoni, S., Shubnikov, E., Choubnikova, J., Mikulecky, M., Michalkova, D., Hlava, P., Teuscher, A. U., Reinli, K., Teuscher, A., Zhao, H. X., Stenhouse, E., Moyeed, R., Demaine, A. G., Millward, B. A., Feltbower, R. G., Holland, P., Campbell, F., Fear, N. T., Wasmuth, H. E., Elliott, R. B., Mclachlan, C., Erhardt, G., Kolb, H., Guaita, G., Pelligra, I., Motzo, C., Obinu, M., Cossu, E., Cirillo, R., Kinalski, M., Kretowski, A., Bingley, P., Kinalska, I., Douek, I. F., Bingley, P. J., Gale, E. A. M., Imagawa, A., Hanafusa, T., Miyagawa, J., Matsuzawa, Y., Iddm, Osaka Study Group, Todd, J. A., Welsh, K., Marshall, S., Nolsoe, R., Kristiansen, O. P., Larsen, Z., Johannesen, J., Jahromi, M. M., Larsen, Z. M., Kyvik, K. O., Jeanclos, E., Schork, N. J., Aviv, A., Sieradzki, J., Malecki, M. T., Klupa, T., Hanna, L., Sieradzka, J., Frey, J., Krolewski, A. S., Calvo, B., Bilbao, J. R., Perez Nanclares, G., Castano, L., Santos, J. L., Perez-Bravo, F., Piquer, S., Puig-Domingo, M., Carrasco, E., Calvillan, M., Leiva, A., Albala, C., Cavallo, M. G., Manca Bitti, M. L., Suraci, C., Crino, A., Giordano, C., Cervoni, M., Sbriglia, M. 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81. [Kallman's syndrome combined with aortic valve anomaly and epilepsy]
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Tomasz Miazgowski, Eisner M, and Czekalski S
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Adult ,Male ,Epilepsy ,Aortic Valve ,Humans ,Kallmann Syndrome - Abstract
Kallman's syndrome is defined clinically as hypogonadotropic hypogonadism associated with anosmia and other congenital abnormalities. There is no report on Kallman's syndrome coexisting with aortic valve anomaly and epilepsy in the available literature. Therefore, the authors considered worthy presenting a case of a 36-years male [correction of female] patient with Kallmann's syndrome combined with aortic valve anomaly, epilepsy and hyperostosis frontalis. Disease history data, clinical examination, the results of hormonal tests and USG helped to establish the diagnosis. Diagnostic and therapeutical problems in such cases have also been discussed.
82. Decreased bone mineral density in patients with insulin-dependent-diabetes,Obnizona gestość mineralna kości u chorych zcukrzyca insulinozalezna
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Tomasz Miazgowski, Andrysiak-Mamos, E., Czekalski, S., and Pynka, S.
83. Association of polymorphism of human renal kallikrein gene promoter with hypertension, salt-sensitivity and urinary kallikrein excretion
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Placha, G., Kaczmarczyk, M., Krystyna Widecka, Gora, J., Adler, G., Czekalski, S., Gaciong, Z., and Ciechanowicz, A.
84. Anthropometric measurements and vertebral deformities
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Johnell, O., Terence O'Neill, Felsenberg, D., Kanis, J., Cooper, C., Silman, A. J., Abendroth, K., Agnusdei, D., Antoniou, A., Aroso, A., Banzer, D., Benevolenskaya, L. I., Bergmann, K., Bhalla, A. K., Cannata Andia, J. B., Czekalski, S., Delmas, P. D., Dequeker, J., Diaz Curiel, M., Diaz Lopez, J. D., Dilsen, G., Eastell, R., Falch, J. A., Felsch, B., Franke, J., Gennari, C., Geusens, P., Havelka, S., Hofman, A., Hoszowski, K., Jajic, I., Janott, J., Kalidis, L., Kirschner, S., Kiss, C., Kruskemper, G., Lauermann, T., Letkovska, A., Lopez Vaz, A., Lorenc, R. S., Lyritis, G., Marchand, F., Marsden, D., Masaryk, P., Matthis, C., Mews, J., Meyer, H. E., Miazgowski, T., Mikhailov, E. E., Nilsson, B., Ortolani, S., Petta, G., Pols, H. A. P., Poor, G., Rapado, A., Raptou, P., Raspe, H., Reeve, J., Reid, D. M., Reisinger, W., Ring, F., Roig Escofet, D., Ruiz Martin, M., Schatz, H., Scheidt-Nave, C., Sosa, M., Todd, C., Varincova, P., Varlow, J., Weber, K., Wieland, E., Williams, R., Woolf, A. D., and Ziegler, R.
85. Circardian rhythm of blood pressure in patients with early phase of primary chronic glomerulonephritis,Dobowy rytm ciśnienia tȩtniczego u chorych we wczesnym okresie pierwotnego przewlekłego kłȩbuszkowego zapalenia nerek
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Łochyńska, K., Oko, A., Ilona Idasiak-Piechocka, and Czekalski, S.
86. The effect of clodronate on bone mineral density and serum osteocalcin in postmenopausal women with osteopenia - a prospective, randomized, placebo-controlled study
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Napierała, K., Tomasz Miazgowski, Hoszowski, K., Bieńkowska, R., Lorenc, R., and Czekalski, S.
87. Plasma atrial natriuretic factor and cyclic GMP in mitral stenosis treated by balloon valvulotomy. Effect of atrial fibrillation.
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Dussaule, J C, primary, Vahanian, A, additional, Michel, P L, additional, Soullier, I, additional, Czekalski, S, additional, Acar, J, additional, and Ardaillou, R, additional
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- 1988
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88. ARG 16 GLY POLYMORPHISM OF BETA2ADRENOCEPTOR GENE AND SALT SENSITIVITY OF BLOOD PRESSURE IN POLISH HYPERTENSIVE
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Ciechanowicz, A. M., Widecka, K., Adler, G., Cyryowski, L., Czekalski, S., and Ciechanowicz, A.
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- 2000
89. POLYMORPHISM OF ALPHAADDUCIN GENE AN SALT SENSITIVITY OF BLOOD PRESSURE IN POLISH HYPERTENSIVES
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Drozd, R., Widecka, K., Adler, G., Cyryowski, L., Czekalski, S., and Ciechanowicz, A.
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- 2000
90. Renal sonography in bipolar patients on long-term lithium treatment.
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Jończyk-Potoczna K, Abramowicz M, Chłopocka-Woźniak M, Strzelczuk-Judka L, Michalak M, Czekalski S Prof, and Rybakowski JK Prof
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- Adult, Aged, Aged, 80 and over, Female, Glomerular Filtration Rate physiology, Humans, Kidney physiopathology, Kidney Function Tests, Male, Middle Aged, Time, Bipolar Disorder drug therapy, Kidney diagnostic imaging, Kidney drug effects, Lithium Compounds therapeutic use, Ultrasonography methods
- Abstract
Purpose: The aim of the study was to analyze sonographic (US) renal findings in lithium-treated bipolar patients and to correlate them with renal function., Methods: Renal US and renal function tests were performed on 120 patients with bipolar disorder. Ninety patients (30 males, 60 females), aged 36-82 years, had received lithium therapy for an average of 16 years, whereas 30 patients (10 males, 20 females), aged 35-85 years, who had never been exposed to lithium, served as controls., Results: In the lithium-treated group, patients with macrocysts (22%) had poorer renal function with higher creatinine serum concentrations, lower estimated glomerular filtration rates, and lower urine specific gravity, compared with the patients without macrocysts. The US changes characteristic for lithium nephropathy (punctate hyperechoic foci, microcysts < 2 mm, and increased echogenicity) were seen in three patients. These patients had been treated with lithium for more than 20 years and had impaired renal function. Sixteen percent of patients in the control group had macrocysts; however, no correlation between their presence and impaired renal function was found., Conclusions: The presence of macrocysts in the kidneys of lithium-treated bipolar patients is associated with impaired renal function. The US changes characteristic for lithium nephropathy are rare, and in our study, were only found in patients treated with lithium for 20 years or more. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44:354-359, 2016., (© 2016 Wiley Periodicals, Inc.)
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- 2016
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91. Vitamin K2 for the treatment of vascular injury in patients with chronic kidney disease.
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Czekalski S and Pawlaczyk K
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- Humans, Osteoporosis, Renal Insufficiency, Chronic drug therapy, Vitamin K, Vascular System Injuries, Vitamin K 2
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- 2015
92. Novel markers of kidney injury in bipolar patients on long-term lithium treatment.
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Rybakowski JK, Abramowicz M, Chłopocka-Wozniak M, and Czekalski S
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- Acute-Phase Proteins, Adult, Aged, Biomarkers metabolism, Female, Glomerular Filtration Rate, Humans, Kidney Diseases physiopathology, Kidney Function Tests, Lipocalin-2, Lipocalins blood, Lithium Compounds therapeutic use, Male, Middle Aged, Proto-Oncogene Proteins blood, Sex Factors, Time Factors, beta 2-Microglobulin urine, Bipolar Disorder drug therapy, Kidney Diseases chemically induced, Lithium Compounds adverse effects
- Abstract
Objectives: We assessed kidney function in long-term lithium-treated bipolar patients compared with age-matched patients not taking lithium, including novel markers of kidney injury such as plasma neutrophil gelatinase-associated lipocalin (NGAL) and urinary beta-2 microglobulin (β2-MG) METHODS: The study comprised 120 patients with bipolar disorder of which 90 (30 males and 60 females) have been receiving lithium for 5-38 (mean 16) years, and 30 (10 males and 20 females) have never been exposed to lithium., Results: Lithium-treated patients, both men and women, showed significantly higher plasma NGAL and urinary β2-MG and lower urine specific gravity and estimated glomerular filtration rate (eGFR), compared with patients not taking lithium. In these patients, serum NGAL did not correlate with any clinical feature or other parameter of kidney function. Urinary β2-MG correlated with serum creatinine and eGFR in the whole group of lithium-treated patients and in addition, in males, with duration of illness, duration of lithium treatment, and urine specific gravity., Conclusions: Lithium treatment causes an impairment of kidney function reflected also by abnormal levels of novel markers of kidney injury. Of these, urinary β2-MG, as a marker of tubular function seems to be better predictor than serum NGAL in lithium-treated patients because it shows multiple clinical and biochemical correlations, especially in men., (Copyright © 2013 John Wiley & Sons, Ltd.)
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- 2013
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93. The association of glycogen synthase kinase-3beta (GSK-3β) gene polymorphism with kidney function in long-term lithium-treated bipolar patients.
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Rybakowski JK, Abramowicz M, Szczepankiewicz A, Michalak M, Hauser J, and Czekalski S
- Abstract
Background: Most bipolar patients experience a reduction in urinary concentrating ability within a few weeks of starting lithium treatment. This phenomenon may be connected with the effect of lithium on the glycogen synthase kinase-3beta (GSK-3β) present in the renal tubules. The GSK-3β gene is located on chromosome 3q13 and possesses a functional -50 C/T polymorphism. In the present study, we estimated this polymorphism in a group of long-term lithium-treated patients and assessed its association with various parameters of kidney function, including novel markers of kidney injury such as serum neutrophil gelatinase-associated lipocalin (NGAL) and urinary beta2-microglobulin (β2-MG)., Methods: The study comprised 78 patients with bipolar mood disorder (25 males, 53 females), aged 36 to 82 (60 ± 11) years. The mean duration of bipolar illness was 6 to 50 (24 ± 10) years, and the patients have been receiving lithium for 5 to 38 (16 ± 9) years. All the patients had the following features, regarded as the phenotypes of kidney functions measured: urine examination for specific gravity evaluation, serum creatinine concentration, and estimated glomerular filtration rate (eGFR) evaluation, as well as the serum concentrations of NGAL and urinary β2-MG. Genotyping of GSK-3β gene -50 C/T polymorphism was done by polymerase chain reaction analysis., Results and Discussion: Thirty-four patients (6 males, 28 females) had the T/T genotype, 37 patients (16 males, 21 females) had the T/C genotype, and 7 patients (3 males, 4 females) had the C/C genotype. Patients homozygous for C allele had significantly higher urine specific gravities (1.019 ± 0.008) compared to the remaining genotypes (1.013 ± 0.007) (p = 0.035), with no influence of the duration of lithium treatment. Other parameters of kidney function (serum creatinine, eGFR, serum NGAL, and urinary β2-MG levels) were not different between genotypes and, again, were not affected by the duration of lithium treatment. There was no correlation between urine specific gravity and other kidney function parameters. The results of our study indicate that the GSK-3β genotype may be connected with lithium-induced impairment of renal concentrating ability in long-term lithium-treated bipolar patients. Limitations of the study include small size of the sample, small number of C/C genotype patients, and a lack of multiple testing analysis of genotypic differences in various measures of kidney function.
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- 2013
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94. Screening for the markers of kidney damage in men and women on long-term lithium treatment.
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Rybakowski JK, Abramowicz M, Drogowska J, Chłopocka-Woźniak M, Michalak M, and Czekalski S
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- Albuminuria physiopathology, Biomarkers urine, Creatinine urine, Female, Glomerular Filtration Rate, Humans, Kidney physiopathology, Male, Middle Aged, Serum Albumin metabolism, Specific Gravity, Time Factors, Biomarkers analysis, Kidney drug effects, Kidney pathology, Lithium adverse effects
- Abstract
Background: Lithium is the most effective therapeutic modality for the prevention of recurrences in bipolar disorder. An important adverse effect of lithium, especially with long-term treatment, is a possibility of a toxic effect on kidney function. Therefore, the aim of the study was to assess kidney function in a group of long-term lithium-treated patients., Material/methods: The study comprised 80 patients with bipolar mood disorder (26 male, 54 female), aged 60 ± 11 years. They had been receiving lithium for 5-38 (16 ± 9) years. Random urine sample was examined for albumin and creatinine excretion, and urinary albumin to creatinine ratio (UACR) was calculated. Specific gravity of the urine sample was recorded. Serum concentration of creatinine was measured and estimated glomerular filtration rate (eGFR) was calculated. Serum concentration of albumin was also measured., Results: Decreased eGFR values <60 ml/min/1.73 m² were found in 23% of patients, significantly more frequently in men that in women (38% vs. 16%, p=0.04). Elevated UACR values (>30 mg/g) were found in 25% of men and 12% of women, respectively. Serum albumin concentration >52 g/l was detected in 19% of patients (17% of men and 20% of women). Specific gravity of the urine, equal to or below 1.005, was recorded in 21% of men and 14% of women., Conclusions: The results confirm the opinion that screening for the markers of kidney damage should be performed in long-term lithium-treated patients for identification of persons with impaired kidney function. Male sex seems to be the risk factor for the development of kidney damage during long-term lithium treatment.
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- 2012
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95. [The effect of long-term lithium treatment on kidney function].
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Rybakowski J, Drogowska J, Abramowicz M, Chłopocka-Woźniak M, and Czekalski S
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- Albuminuria chemically induced, Antimanic Agents therapeutic use, Bipolar Disorder drug therapy, Diabetes Insipidus chemically induced, Glomerular Filtration Rate drug effects, Humans, Kidney Failure, Chronic chemically induced, Kidney Function Tests, Lithium Carbonate therapeutic use, Mood Disorders chemically induced, Risk Factors, Antimanic Agents adverse effects, Kidney drug effects, Kidney Diseases chemically induced, Lithium Carbonate adverse effects
- Abstract
In 1963 it was first demonstrated that long-term lithium administration exerts a "mood-stabilising" effect, preventing recurrences of mania and depression in bipolar affective disorder. Despite the introduction of many other drugs having mood-stabilising effect, lithium still remains the first choice drug for the prophylaxis of affective episodes in mood disorder. Lithium is eliminated nearly exclusively by the kidneys: lithium clearance is proportional to creatinine clearance and is influenced by natriuretic and antinatriuretic factors. Nowadays, nearly 40-year experience with long-term lithium treatment point to a possibility of nephrotoxic effects of this ion. Impaired urinary concentrating ability, which, in a few patients can reach an intensity of diabetes insipidus, can occur after several weeks of lithium administration. Favourable results in the treatment of diabetes insipidus have been obtained with amiloride, the drug which block epithelial sodium channel. However, after 10-20 years of treatment, lithium-induced interstitial nephropathy may be demonstrated in some patients, which, in small proportion of the latter may lead to end-stage renal disease. Lithium-induced hipercalcemia and nephrotic syndrome are rare complications of lithium therapy. In patients on long-term lithium therapy periodic monitoring of kidney function by measuring serum creatinine concentration and glomerular filtration rate is necessary. In case of detecting nephropathy, a discontinuation of lithium sho uld be considered. The patient in whom lithium was discontinued due to nephropathy should remain in nephrological treatment.
- Published
- 2012
96. Pregnancy in diabetic woman with coexisting hypothyroidism, coronary artery disease and with early onset nephrotic syndrome--a case report.
- Author
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Wender-Ozegowska E, Zawiejska A, Wanic-Kossowska M, Ozegowski S, Brazert J, and Czekalski S
- Subjects
- Adult, Age of Onset, Female, Humans, Hypothyroidism complications, Pregnancy, Coronary Artery Disease complications, Diabetes Mellitus, Type 1 complications, Hypothyroidism physiopathology, Nephrotic Syndrome complications, Pregnancy Complications, Cardiovascular diagnosis, Pregnancy Complications, Hematologic diagnosis, Pregnancy in Diabetics diagnosis
- Abstract
We present a case of pregnancy in 28-years old nulliparous woman with an over 20-years long history of diabetes, hypothyroidism, diabetic nephropathy with nephrotic syndrome, retinopathy and coronary artery disease treated with PCA prior the pregnancy (class H diabetes, according to White classification).
- Published
- 2012
97. Therapeutic equivalence of epoetin zeta and alfa, administered subcutaneously, for maintenance treatment of renal anemia.
- Author
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Krivoshiev S, Wizemann V, Czekalski S, Schiller A, Pljesa S, Wolf-Pflugmann M, Siebert-Weigel M, Koytchev R, and Bronn A
- Subjects
- Adult, Aged, Anemia etiology, Epoetin Alfa, Erythropoietin pharmacokinetics, Female, Hematinics pharmacokinetics, Hemoglobins analysis, Humans, Injections, Subcutaneous, Kidney Failure, Chronic therapy, Male, Middle Aged, Recombinant Proteins, Renal Dialysis adverse effects, Single-Blind Method, Therapeutic Equivalency, Anemia drug therapy, Erythropoietin therapeutic use, Hematinics therapeutic use
- Abstract
Introduction: The primary objective of the trial was to prove the therapeutic equivalence of epoetin zeta to epoetin alfa when administered subcutaneously for maintaining target hemoglobin (Hb) in patients with renal anemia on chronic hemodialysis. Additional information was provided on the safety and tolerability of epoetin zeta with particular focus on the formation of anti-erythropoietin antibodies., Methods: A total of 462 patients were randomized to either epoetin zeta or alfa for 28 weeks after an open period of dose adjustment of 12-16 weeks with only epoetin zeta. The aim of treatment was to maintain Hb between 10.0-12.0 g/dL with constant epoetin dosage. Primary endpoints were the mean Hb level and the mean weekly epoetin dosage during the last 4 weeks of treatment. Safety endpoints were the occurrence of anti-erythropoietin antibodies, incidence of Hb levels above 13 g/dL, ratings of tolerability, and adverse events (AEs)., Results: The mean Hb level (+/-SD) during the last 4 weeks of treatment was 10.94+/-0.84 g/dL (epoetin zeta) and 11.02+/-0.94 g/dL (epoetin alfa). The 95% confidence interval (CI) (''C0.28 g/dL to 0.12 g/dL) was entirely within the predefined equivalence range (+/-0.5 g/dL). The mean weekly epoetin dosage per body weight over the last 4 weeks of treatment was 97.0+/-94.3 IU/kg/week (epoetin zeta) and 86.0+/-78.0 IU/kg/week (epoetin alfa). The 95% CI (''C8.06 IU/kg/week to 29.96 IU/kg/week) was also within the predefined equivalence range of +/-45 IU/kg/week. The most common AEs were infections and infestations (15.1% of patients on epoetin zeta and 14.8% of patients on epoetin alfa). None of the patients developed anti-erythropoietin antibodies., Conclusions: Epoetin zeta, administered subcutaneously, is equivalent to epoetin alfa in respect of its clinical efficacy. The safety profile of both products is similar: no unexpected AEs were observed, no patients developed anti-erythropoietin antibodies, and both epoetin preparations were well tolerated.
- Published
- 2010
- Full Text
- View/download PDF
98. Elevated urinary fibronectin excretion predicts poor outcome in patients with primary chronic glomerulonephritis.
- Author
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Idasiak-Piechocka I, Oko A, Pawliczak E, Kaczmarek E, and Czekalski S
- Subjects
- Adult, Biomarkers urine, Chronic Disease, Disease Progression, Female, Follow-Up Studies, Glomerular Filtration Rate physiology, Glomerulonephritis therapy, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Treatment Outcome, Young Adult, Fibronectins urine, Glomerulonephritis diagnosis, Glomerulonephritis urine
- Abstract
Background/aims: Fibronectin (FN) is one of the major matrix proteins in the kidney. The accumulation of FN fragments in inflamed glomeruli could contribute to the progression of renal injury. In the present study, the urinary FN excretion (UFN) was measured for evaluation of its possible role as a prognostic marker in patients with newly diagnosed chronic glomerulonephritis (GN)., Methods: In 55 patients with newly diagnosed biopsy-proven chronic GN, UFN was measured using an enzyme-immunossay kit. The progression of kidney disease was defined as a reduction of the estimated glomerular filtration rate (eGFR) >or=5 ml/min/year during the 4-year follow-up., Results: The mean UFN in patients with GN (245.0 +/- 229.2 ng/mmol creatinine) was higher than in the 19 healthy subjects (100.7 +/- 87.3 ng/mmol creatinine; p < 0.002). No correlations between the initial UFN and eGFR and proteinuria were found. We did not find any association between UFN and the severity of glomerular sclerosis or the intensity of interstitial fibrosis. The progressive fall of eGFR was recorded in 13 patients (progressors). The mean initial UFN was significantly higher in progressors than in nonprogressors (p < 0.01). In logistic regression analysis, the initial high UFN was identified as independent factor predicting kidney function deterioration., Conclusion: These results indicate that UFN measured before treatment could serve as an additional prognostic marker of a poor outcome in patients with newly diagnosed primary GN.
- Published
- 2010
- Full Text
- View/download PDF
99. Effect of intradialytic intravenous administration of omega-3 fatty acids on nutritional status and inflammatory response in hemodialysis patients: a pilot study.
- Author
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Szklarek-Kubicka M, Fijałkowska-Morawska J, Zaremba-Drobnik D, Uciński A, Czekalski S, and Nowicki M
- Subjects
- Body Mass Index, C-Reactive Protein drug effects, Fatty Acids, Omega-3 blood, Female, Humans, Inflammation drug therapy, Inflammation Mediators blood, Interleukin-6 blood, Kidney Failure, Chronic therapy, Lipids blood, Male, Middle Aged, Pilot Projects, Prospective Studies, Serum Albumin drug effects, Transferrin drug effects, Fatty Acids, Omega-3 administration & dosage, Inflammation blood, Kidney Failure, Chronic blood, Nutritional Status drug effects, Parenteral Nutrition methods, Renal Dialysis methods
- Abstract
Objective: Because omega-3 polyunsaturated fatty acids (PUFAs) may have anti-inflammatory properties, we tested the hypothesis that intradialytic, intravenous omega-3 PUFA treatment, combined with dietary supplementation, can modify the inflammatory response to dialysis, and influence the nutritional status of hemodialysis (HD) patients., Methods: Twenty HD patients with serum albumin at <39g/L received 100mL of 10% omega-3 PUFA emulsion during 11 consecutive HD sessions. Body mass index (BMI), serum albumin, transferrin, and lipids were measured before and after treatment. Serum interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) levels were determined before and after the HD session at baseline and after 4 weeks of treatment., Results: No adverse events were evident during the study. There were no significant changes in BMI, serum albumin, transferin, total and low-density lipoprotein cholesterol, and triglycerides. Predialysis hsCRP and IL-6 did not change. There was a significant increase in hsCRP (P=.01) and a tendency of IL-6 concentration to increase during the HD session before treatment (P=.067). In contrast, neither hsCRP (P=.21) nor IL-6 (P=.26) changed during the final HD session. Neither urea reduction ratio nor Kt/V changed significantly during the study, but the normalized protein catabolic ratio increased after treatment (P=.003)., Conclusions: Short-term parenteral administration of omega-3 PUFA is safe and well-tolerated by HD patients. The intervention does not significantly influence markers of inflammation or change the nutritional status of chronic HD patients, but it may attenuate the inflammatory response to HD sessions.
- Published
- 2009
- Full Text
- View/download PDF
100. [Nephrological care in Wielkopolska-region of Poland in 2009--realization of the united idea].
- Author
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Czekalski S
- Subjects
- Chronic Disease, Humans, Kidney Transplantation, Peritoneal Dialysis, Poland, Renal Dialysis, Ambulatory Care Facilities organization & administration, Delivery of Health Care, Integrated organization & administration, Kidney Diseases therapy, Renal Replacement Therapy methods
- Abstract
The establishment of net of the dialysis centers within the distance of 50 km each other, created the basis for realization of united idea for organization of nephrological care in the Wielkopolska-region of Poland. Nephrological care consists of both an integrated methods of the renal replacement therapy: hemodialysis, peritoneal dialysis and kidney transplantation and the screening for chronic kidney disease, its early diagnosis and effective treatment which slow-down the progression of the disease. The nephrological ambulatory, associated with dialysis centers and the nephrological departments with dialysis center and ambulatory play an important role in the integrated nephrological care. As the result of an accessibility of nephrological consultation in the ambulatory located about 25-30 km from the patients home, the nephrological care in Wielkopolska region constantly improves.
- Published
- 2009
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