16,792 results on '"Curto, A."'
Search Results
52. Recalculate Without Recomputing
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Dias Curto, José
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- 2024
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53. Optimization of the application of cationic agent in the screen printing paste with reactive dye on cotton substrate
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Rainert, Karine Thaise, Herpich, Heiderose, Valle, Rita De Cássia Siqueira Curto, and Valle, José Alexandre Borges
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- 2024
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54. DNA metabarcoding reveals the diet of the invasive fish Oreochromis mossambicus in mangroves of São Tomé Island (Gulf of Guinea)
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Nogueira, S., Curto, M., Gkenas, C., Afonso, F., Dias, D., Heumüller, J., Félix, P. M., de Lima, R. F., Chaínho, P., Brito, A. C., and Ribeiro, F.
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- 2024
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55. The CORALIE survey for southern extrasolar planets XIX. Brown dwarfs and stellar companions unveiled by radial velocity and astrometry
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Barbato, D., Ségransan, D., Udry, S., Unger, N., Bouchy, F., Lovis, C., Mayor, M., Pepe, F., Queloz, D., Santos, N. C., Delisle, J. B., Figueira, P., Marmier, M., Matthews, E. C., Curto, G. Lo, Venturini, J., Chaverot, G., Cretignier, M., Otegi, J. F., and Stalport, M.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
A historical planet-search on a sample of 1647 nearby southern main sequence stars has been ongoing since 1998 with the CORALIE spectrograph at La Silla Observatory, with a backup subprogram dedicated to the monitoring of binary stars. We review 25 years of CORALIE measurements and search for Doppler signals consistent with stellar or brown dwarf companions to produce an updated catalog of both known and previously unpublished binary stars in the planet-search sample, assessing the binarity fraction of the stellar population and providing perspective for more precise planet-search in the binary sample. We perform new analysis on the CORALIE planet-search sample radial velocity measurements, searching for stellar companions and obtaining orbital solutions for both known and new binary systems. We perform simultaneous radial velocity and proper motion anomaly fits on the subset of these systems for which Hipparcos and Gaia astrometry measurements are available, obtaining accurate estimates of true mass for the companions. We find 218 stars in the CORALIE sample to have at least one stellar companion, 130 of which are not yet published in the literature and for which we present orbital solutions. The use of proper motion anomaly allow us to derive true masses for the stellar companions in 132 systems, which we additionally use to estimate stability regions for possible planetary companions on circumprimary or circumbinary orbits. Finally, we produce detection limit maps for each star in the sample and obtain occurrence rates of $0.43^{+0.23}_{-0.11}\%$ and $12.69^{+0.87}_{-0.77}\%$ for brown dwarf and stellar companions respectively in the CORALIE sample., Comment: 34 pages, 15 figures, accepted for publication in A&A
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- 2023
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56. The crime of being poor
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Curto, Georgina, Kiritchenko, Svetlana, Nejadgholi, Isar, and Fraser, Kathleen C.
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Computer Science - Computation and Language - Abstract
The criminalization of poverty has been widely denounced as a collective bias against the most vulnerable. NGOs and international organizations claim that the poor are blamed for their situation, are more often associated with criminal offenses than the wealthy strata of society and even incur criminal offenses simply as a result of being poor. While no evidence has been found in the literature that correlates poverty and overall criminality rates, this paper offers evidence of a collective belief that associates both concepts. This brief report measures the societal bias that correlates criminality with the poor, as compared to the rich, by using Natural Language Processing (NLP) techniques in Twitter. The paper quantifies the level of crime-poverty bias in a panel of eight different English-speaking countries. The regional differences in the association between crime and poverty cannot be justified based on different levels of inequality or unemployment, which the literature correlates to property crimes. The variation in the observed rates of crime-poverty bias for different geographic locations could be influenced by cultural factors and the tendency to overestimate the equality of opportunities and social mobility in specific countries. These results have consequences for policy-making and open a new path of research for poverty mitigation with the focus not only on the poor but on society as a whole. Acting on the collective bias against the poor would facilitate the approval of poverty reduction policies, as well as the restoration of the dignity of the persons affected.
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- 2023
57. An Agent-Based Model for Poverty and Discrimination Policy-Making
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Montes, Nieves, Curto, Georgina, Osman, Nardine, and Sierra, Carles
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Computer Science - Multiagent Systems - Abstract
The deceleration of global poverty reduction in the last decades suggests that traditional redistribution policies are losing their effectiveness. Alternative ways to work towards the #1 United Nations Sustainable Development Goal (poverty eradication) are required. NGOs have insistingly denounced the criminalization of poverty, and the social science literature suggests that discrimination against the poor (a phenomenon known as aporophobia) could constitute a brake to the fight against poverty. This paper describes a proposal for an agent-based model to examine the impact that aporophobia at the institutional level has on poverty levels. This aporophobia agent-based model (AABM) will first be applied to a case study in the city of Barcelona. The regulatory environment is central to the model, since aporophobia has been identified in the legal framework. The AABM presented in this paper constitutes a cornerstone to obtain empirical evidence, in a non-invasive way, on the causal relationship between aporophobia and poverty levels. The simulations that will be generated based on the AABM have the potential to inform a new generation of poverty reduction policies, which act not only on the redistribution of wealth but also on the discrimination of the poor.
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- 2023
58. Fairness: from the ethical principle to the practice of Machine Learning development as an ongoing agreement with stakeholders
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Curto, Georgina and Comim, Flavio
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
This paper clarifies why bias cannot be completely mitigated in Machine Learning (ML) and proposes an end-to-end methodology to translate the ethical principle of justice and fairness into the practice of ML development as an ongoing agreement with stakeholders. The pro-ethical iterative process presented in the paper aims to challenge asymmetric power dynamics in the fairness decision making within ML design and support ML development teams to identify, mitigate and monitor bias at each step of ML systems development. The process also provides guidance on how to explain the always imperfect trade-offs in terms of bias to users.
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- 2023
59. The ESO's Extremely Large Telescope Working Groups
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Padovani, Paolo, Cirasuolo, Michele, van der Burg, Remco, Cantalloube, Faustine, George, Elizabeth, Kasper, Markus, Leschinski, Kieran, Martins, Carlos, Milli, Julien, Möhler, Sabine, Neeser, Mark, Neichel, Benoit, Otarola, Angel, Sánchez-Janssen, Rubén, Serra, Benoit, Smette, Alain, Valenti, Elena, Verinaud, Christophe, Vernet, Joël, Absil, Olivier, Agapito, Guido, Andersen, Morten, Arcidiacono, Carmelo, Arko, Matej, Baudoz, Pierre, Beltramo-Martin, Olivier, Biancalani, Enrico, Bierwirth, Thomas, Burtscher, Leonard, Carlà, Giulia, Castro-Almazán, Julio A., Cheffot, Anne-Laure, Coccato, Lodovico, Correia, Carlos, Fetick, Romain, Fiorentino, Giuliana, Fusco, Thierry, García-Lorenzo, Begoña, Fusillo, Nicola Gentile, Gonzalez, Oscar, Grazian, Andrea, Gullieuszik, Marco, Hainaut, Olivier, Ivanov, Valentin, Kaasinen, Melanie, Kaddad, Darshan, Kamiński, Tomasz, Kausch, Wolfgang, Kerber, Florian, Kimeswenger, Stefan, Kokotanekova, Rosita, Kuznetsov, Arseniy, Lau, Alexis, Louarn, Miska Le, Lemmel, Frédéric, Liske, Jochen, Curto, Gaspare Lo, Lucsanyi, David, Lundin, Lars, Noll, Stefan, Oberti, Sylvain, Osborn, James, Masciadri, Elena, Milaković, Dinko, Murphy, Michael T., Pedichini, Fernando, Santaella, Miguel Pereira, Piazzesi, Roberto, López, Javier Piqueras, Plantet, Cédric, Prod'homme, Thibaut, Przybilla, Norbert, Puech, Mathieu, Reid, Derryck T., Reiners, Ansgar, Rijnenberg, Rutger, Rodrigues, Myriam, Rossi, Fabio, Routledge, Laurence, Smit, Hans, Tecza, Mathias, Thatte, Niranjan, van Boekel, Roy, Verma, Aprajita, and Vigan, Arthur
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Since 2005 ESO has been working with its community and industry to develop an extremely large optical/infrared telescope. ESO's Extremely Large Telescope, or ELT for short, is a revolutionary ground-based telescope that will have a 39-metre main mirror and will be the largest visible and infrared light telescope in the world. To address specific topics that are needed for the science operations and calibrations of the telescope, thirteen specific working groups were created to coordinate the effort between ESO, the instrument consortia, and the wider community. We describe here the goals of these working groups as well as their achievements so far., Comment: 8 pages, 4 figures
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- 2023
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60. Graph rules for recurrent neural network dynamics: extended version
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Curto, Carina and Morrison, Katherine
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Quantitative Biology - Neurons and Cognition - Abstract
This is an extended version of our survey article, "Graph rules for recurrent neural network dynamics," to appear in the April 2023 edition of the Notices of the AMS. It includes additional results, derivations, figures, references, and a set of open questions., Comment: 32 pages (double-column), 25 figures, 2 tables
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- 2023
61. Performance of three model-based iterative reconstruction algorithms using a CT task-based image quality metric
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Muti, G., Riga, S., Berta, L., Curto, D., De Mattia, C., Felisi, M., Rizzetto, F., Torresin, A., Vanzulli, A., and Colombo, P. E.
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Physics - Medical Physics - Abstract
In this study we evaluated the task-based image quality of a low contrast clinical task for the abdomen protocol (e.g., pancreatic tumour) of three different CT vendors, exploiting three model-based iterative reconstruction (MBIR) levels. We used three CT systems equipped with a full, partial, advanced MBIR algorithms. Acquisitions were performed on a phantom at three dose levels. Acquisitions were reconstructed with a standard kernel, using filtered back projection algorithm (FBP) and three levels of the MBIR. The noise power spectrum (NPS), the normalized one (nNPS) and the task-based transfer function (TTF) were computed following the method proposed by the American Association of Physicists in Medicine task group report-233 (AAPM TG-233). Detectability index (d') of a small lesion (small feature; 100 HU and 5-mm diameter) was calculated using non-prewhitening with eye-filter model observer (NPWE).The nNPS, NPS and TTF changed differently depending on CT system. Higher values of d' were obtained with advanced-MBIR, followed by full-MBIR and partial-MBIR.Task-based image quality was assessed for three CT scanners of different vendors, considering a clinical question. Detectability can be a tool for protocol optimisation and dose reduction since the same dose levels on different scanners correspond to different d' values., Comment: 7 pages, 5 figures, 3 tables
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- 2023
62. Helicobacter P ylori infection in children with inflammatory bowel disease: a prospective multicenter study
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Emanuele Dilaghi, Enrico Felici, Edith Lahner, Emanuela Pilozzi, Silvia Furio, Livia Lucchini, Giovanna Quatrale, Marisa Piccirillo, Pasquale Parisi, Sara Curto, Bruno Annibale, Alessandro Ferretti, Maurizio Mennini, Severino Persechino, and Giovanni Di Nardo
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Helicobacter pylori infection ,H. pylori gastritis ,Inflammatory Bowel Disease ,Children ,Pediatrics ,RJ1-570 - Abstract
Abstract Background The relationship between Helicobacter-pylori(Hp)infection and inflammatory-bowel-disease(IBD) in pediatric-patients remains controversial. We aimed to assess the Hp-infection occurrence in newly-diagnosed pediatric-patients with IBD compared to no-IBD patients. Additionally, we aimed to examine differences in clinical-activity-index(CAI) and endoscopic-severity-score(ESS)between IBD-patients with and without Hp-infection, at baseline and at 1-year-follow-up(FU), after eradication-therapy(ET). Methods IBD diagnosis was based on Porto-criteria, and all patients underwent gastroscopy at baseline and 1-year FU. For Crohn's-disease(CD) and ulcerative colitis(UC), IBD-CAI and -ESS were classified using PCDAI/SES-CD and PUCAI/UCEIS, respectively. Results 76 IBD-patients were included in the study[35 F(46.1%),median-age 12(range 2–17)]. CD and UC were diagnosed in 29(38.2%) and 45(59.2%)patients, respectively, and unclassified-IBD in two(2.6%)patients. Non-IBD patients were 148[71 F(48.0%),median-age 12(range 1–17)]. Hp-infection at baseline was reported in 7(9.2%) and 18(12.2%)IBD and non-IBD patients, respectively(p = 0.5065). The 7 IBD patients with Hp infection were compared to 69 IBD patients without Hp-infection at baseline evaluation, and no significant differences were reported considering CAI and ESS in these two groups. At 1-year FU, after ET, IBD patients with Hp infection improved, both for CAI and ESS, but statistical significance was not reached. Conclusion The occurrence of Hp-infection did not differ between IBD and no-IBD patients. No differences in CAI or ESS were observed at the diagnosis, and after ET no worsening of CAI or ESS was noted at one-year FU, between Hp-positive and -negative IBD patients.
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- 2024
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63. A longitudinal pilot study examining the influence of the orthodontic system chosen in adult patients (brackets versus aligners) on oral health-related quality of life and anxiety
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Laura Correa, Alberto Albaladejo, and Adrián Curto
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Orthodontics ,Brackets ,Aligners ,Oral health-related quality of life ,Anxiety ,Dentistry ,RK1-715 - Abstract
Abstract Background In recent years, the demand for orthodontic treatment with aligners has increased, led by patient need, as aligners typically provide them with improved aesthetics and less physical discomfort. In deciding with the patient on an appropriate orthodontic system, it is important to take into account the potential discomfort and the perceptions that patients have in relation to their treatment. The objective of this study was to analyze the influence of brackets or aligners on oral health-related quality of life (OHRQoL) and anxiety levels in a sample of adult patients during the first month of treatment. Methods The pilot study was carried out at the Dental Clinic of the University of Salamanca between November 2023 and February 2024. Eighty adult patients who initiated orthodontic treatment were selected and divided into two groups: the brackets group (Victory®; 3 M Unitek, California, USA) (n = 40) and the aligners group (Invisalign®; Align Technology, California, USA) (n = 40). OHRQoL was analyzed using the Oral Health Impact Profile-14 (OHIP-14) questionnaire, and anxiety was analyzed using the State–Trait Anxiety Inventory (STAI). The follow-up time was one month, with scores recorded at the beginning (T0) and one month after starting treatment (T1). Results The mean patient age was 33.70 (± 5.45) years old. The total sample (n = 80) consisted of 66.2% men and 33.8% women. In the brackets group, one month after starting treatment, the dimension with the highest impact was that of physical pain (5.62 ± 1.51). In the aligners group, where the dimension of psychological disability had the highest score (4.22 ± 1.02). In the brackets group the total OHIP score was higher at one month (T1) (33.98 ± 6.81) than at the start of treatment (T0) (21.80 ± 3.34); this greater impact on OHRQoL one month after starting treatment was not observed in the aligners group (T1 = 27.33 ± 6.83; T0 = 27.33 ± 6.22). The orthodontic system used did not influence participants’ anxiety (p > 0.05). Age and sex were not influential factors in either OHRQoL or anxiety. Conclusions The bracket system significantly influenced patients’ OHRQoL. In the sample studied, no influence of the orthodontic system (brackets versus aligners) on anxiety was observed.
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- 2024
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64. Combustion Diagnosis in a Spark-Ignition Engine Fueled with Syngas at Different CO/H2 and Diluent Ratios
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Santiago Martinez-Boggio, Pedro Teixeira Lacava, Felipe Solferini de Carvalho, and Pedro Curto-Risso
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syngas ,hydrogen ,combustion diagnosis ,flame image processing ,Chemical engineering ,TP155-156 - Abstract
The gasification of residues into syngas offers a versatile gaseous fuel that can be used to produce heat and power in various applications. However, the application of syngas in engines presents several challenges due to the changes in its composition. Such variations can significantly alter the optimal operational conditions of the engines that are fueled with syngas, resulting in combustion instability, high engine variability, and misfires. In this context, this work presents an experimental investigation conducted on a port-fuel injection spark-ignition optical research engine using three different syngas mixtures, with a particular focus on the effects of CO/H2 and diluent ratios. A comparative analysis is made against methane, considered as the baseline fuel. The in-cylinder pressure and related parameters are examined as indicators of combustion behavior. Additionally, 2D cycle-resolved digital visualization is employed to trace flame front propagation. Custom image processing techniques are applied to estimate flame speed, displacement, and morphological parameters. The engine runs at a constant speed (900 rpm) and with full throttle like stationary engine applications. The excess air–fuel ratios vary from 1.0 to 1.4 by adjusting the injection time and the spark timing according to the maximum brake torque of the baseline fuel. A thermodynamic analysis revealed notable trends in in-cylinder pressure traces, indicative of differences in combustion evolution and peak pressures among the syngas mixtures and methane. Moreover, the study quantified parameters such as the mass fraction burned, combustion stability (COVIMEP), and fuel conversion efficiency. The analysis provided insights into flame morphology, propagation speed, and distortion under varying conditions, shedding light on the influence of fuel composition and air dilution. Overall, the results contribute to advancing the understanding of syngas combustion behavior in SI engines and hold implications for optimizing engine performance and developing numerical models.
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- 2024
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65. Connected Automated and Human-Driven Vehicle Mixed Traffic in Urban Freeway Interchanges: Safety Analysis and Design Assumptions
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Anna Granà, Salvatore Curto, Andrea Petralia, and Tullio Giuffrè
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urban freeways interchanges ,surrogate safety measures ,connected automated vehicles ,VISSIM ,road design ,Mechanical engineering and machinery ,TJ1-1570 ,Machine design and drawing ,TJ227-240 ,Motor vehicles. Aeronautics. Astronautics ,TL1-4050 - Abstract
The introduction of connected automated vehicles (CAVs) on freeways raises significant challenges, particularly in interactions with human-driven vehicles, impacting traffic flow and safety. This study employs traffic microsimulation and surrogate safety assessment measures software to delve into CAV–human driver interactions, estimating potential conflicts. While previous research acknowledges that human drivers adjust their behavior when sharing the road with CAVs, the underlying reasons and the extent of associated risks are not fully understood yet. The study focuses on how CAV presence can diminish conflicts, employing surrogate safety measures and real-world mixed traffic data, and assesses the safety and performance of freeway interchange configurations in Italy and the US across diverse urban contexts. This research proposes tools for optimizing urban layouts to minimize conflicts in mixed traffic environments. Results reveal that adding auxiliary lanes enhances safety, particularly for CAVs and rear-end collisions. Along interchange ramps, an exclusive CAV stream performs similarly to human-driven ones in terms of longitudinal conflicts, but mixed traffic flows, consisting of both CAVs and human-driven vehicles, may result in more conflicts. Notably, when CAVs follow human-driven vehicles in near-identical conditions, more conflicts arise, emphasizing the complexity of CAV integration and the need for careful safety measures and roadway design considerations.
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- 2024
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66. CÂNCER DE MAMA: O USO DE FERRAMENTAS DIGITAIS PARA MANEJO DE PACIENTE PORTADORA DA MUTAÇÃO BRCA1
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Lacerda, Brunella Curto Cristianes, primary, Silva, João Victor Caetano da, additional, Pereira, Pedro Lucas Alves, additional, Daleprane, Vinicius Eduardo, additional, Caetano, Sumaya Scherrer Senna, additional, Uchiya, Taissa dos Santos, additional, Santana, Gabriel Mendonça, additional, Louro, Luana Santos, additional, Louro, Thomas Erik Santos, additional, Casotti, Matheus Correia, additional, Carvalho, Elizeu Fagundes de, additional, Louro, Iúri Drumond, additional, and Meira, Débora Dummer, additional
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- 2024
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67. Monte Carlo Simulation for Project Risk Prioritisation
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Acebes, Fernando, primary, Curto, David, additional, González-Varona, José Manuel, additional, and Pajares, Javier, additional
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- 2024
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68. Sequence generation in inhibition-dominated neural networks
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Parmelee, Caitlyn, Alvarez, Juliana Londono, Curto, Carina, and Morrison, Katherine
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Quantitative Biology - Neurons and Cognition - Abstract
This is a brief overview of results from [arXiv:2107.10244, ref 11], on network architectures that produce sequential dynamics in a special family of inhibition-dominated neural networks. It was written for SIAM DSWeb., Comment: 6 pages, 4 figures, appeared in SIAM DSWeb, 2022
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- 2022
69. Stellar signal components seen in HARPS and HARPS-N solar radial velocities
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Moulla, K. Al, Dumusque, X., Figueira, P., Curto, G. Lo, Santos, N. C., and Wildi, F.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Context. Radial velocity (RV) measurements induced by the presence of planets around late-type stars are contaminated by stellar signals that are of the order of a few meters per second in amplitude, even for the quietest stars. Those signals are induced by acoustic oscillations, convective granulation patterns, active regions co-rotating with the stellar surface, and magnetic activity cycles. Aims. This study investigates the properties of all coherent stellar signals seen on the Sun on timescales up to its sidereal rotational period. By combining HARPS and HARPS-N solar data spanning several years, we are able to clearly resolve signals on timescales from minutes to several months. Methods. We use a Markov Chain Monte Carlo (MCMC) mixture model to determine the quality of the solar data based on the expected airmass-magnitude extinction law. We then fit the velocity power spectrum of the cleaned and heliocentric RVs with all known variability sources, to recreate the RV contribution of each component. Results. After rejecting variations caused by poor weather conditions, we are able to improve the average intra-day root mean square (RMS) value by a factor of ~1.8. On sub-rotational timescales, we are able to fully recreate the observed RMS of the RV variations. In order to also include rotational components and their strong alias peaks introduced by nightly sampling gaps, the alias powers are accounted for by being redistributed to the central frequencies of the rotational harmonics. Conclusions. In order to enable a better understanding and mitigation of stellar activity sources, their respective impact on the total RV must be well-measured and characterized. We are able to recreate RV components up to rotational timescales, which can be further used to analyse the impact of each individual source of stellar signals on the detectability of exoplanets., Comment: Accepted for publication in A&A
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- 2022
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70. Time-dependent moments from partial differential equations and the time-dependent set of atoms
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Curto, Raúl E., di Dio, Philipp J., Korda, Milan, and Magron, Victor
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Mathematics - Functional Analysis ,Primary: 47A57, 44A60, Secondary: 30E05, 65D32 - Abstract
We study the time-dependent moments and associated polynomials arising from the partial differential equation $\partial_t f = \nu\Delta f + g\cdot\nabla f + h\cdot f$, and consider in detail the dual equation. For the heat equation we find that several non-negative polynomials which are not sums of squares become sums of squares under the heat equation in finite time. We show that every non-negative polynomial in $\mathbb{R}[x,y,z]_{\leq 4}$ becomes a sum of squares in finite time under the heat equation. We solve the problem of moving atoms under the equation $\partial_t f = g\cdot\nabla f + h\cdot f$ with $f_0 = \mu_0$ being a finitely atomic measure. The time evolution $\mu_t = \sum_{i=1}^k c_i(t)\cdot \delta_{x_i(t)}$ of the atom positions $x_i(t)$ are described by the transport term $g\cdot\nabla$ and the time-dependent coefficients $c_i(t)$ have an explicit solution depending on $x_i(t)$, $h$, and $\mathrm{div}\, g$., Comment: Extended Results
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- 2022
71. Planetary system around LTT 1445A unveiled by ESPRESSO: Multiple planets in a triple M-dwarf system
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Lavie, B., Bouchy, F., Lovis, C., Osorio, M. Zapatero, Deline, A., Barros, S., Figueira, P., Sozzetti, A., Hernandez, J. I. Gonzalez, Lillo-Box, J., Rodrigues, J., Mehner, A., Damasso, M., Adibekyan, V., Alibert, Y., Prieto, C. Allende, Cristiani, S., DOdorico, V., Di Marcantonio, P., Ehrenreich, D., Santos, R. Genova, Curto, G. Lo, Martins, C. J. A. P., Micela, G., Molaro, P., Nunes, N., Palle, E., Pepe, F., Poretti, E., Rebolo, R., Santos, N., Sousa, S., Mascareno, A. Suarez, Tabrenero, H., and Udry, S.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present radial velocity follow-up obtained with ESPRESSO of the M-type star LTT 1445A (TOI-455), for which a transiting planet b with an orbital period of~5.4 days was detected by TESS. We report the discovery of a second transiting planet (LTT 1445A c) and a third non-transiting candidate planet (LTT 1445A d) with orbital periods of 3.12 and 24.30 days, respectively. The host star is the main component of a triple M-dwarf system at a distance of 6.9 pc. We used 84 ESPRESSO high-resolution spectra to determine accurate masses of 2.3$\pm$0.3 $\mathrm{M}_\oplus$ and 1.0$\pm$0.2 $\mathrm{M}_\oplus$ for planets b and c and a minimum mass of 2.7$\pm$0.7 $\mathrm{M}_\oplus$ for planet d. Based on its radius of 1.43$\pm0.09$ $\mathrm{R}_\oplus$ as derived from the TESS observations, LTT 1445A b has a lower density than the Earth and may therefore hold a sizeable atmosphere, which makes it a prime target for the James Webb Space Telescope. We used a Bayesian inference approach with the nested sampling algorithm and a set of models to test the robustness of the retrieved physical values of the system. There is a probability of 85$\%$ that the transit of planet c is grazing, which results in a retrieved radius with large uncertainties at 1.60$^{+0.67}_{-0.34}$ $\mathrm{R}_\oplus$. LTT 1445A d orbits the inner boundary of the habitable zone of its host star and could be a prime target for the James Webb Space Telescope., Comment: 31 pages, 20 figures Accepted A&A
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- 2022
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72. Detection of barium in the atmospheres of the ultra-hot gas giants WASP-76b and WASP-121b
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Silva, T. Azevedo, Demangeon, O. D. S., Santos, N. C., Allart, R., Borsa, F., Cristo, E., Esparza-Borges, E., Seidel, J. V., Palle, E., Sousa, S. G., Tabernero, H. M., Osorio, M. R. Zapatero, Cristiani, S., Pepe, F., Rebolo, R., Adibekyan, V., Alibert, Y., Barros, S. C. C., Bouchy, F., Bourrier, V., Curto, G. Lo, Di Marcantonio, P., D'Odorico, V., Ehrenreich, D., Figueira, P., Hernández, J. I. González, Lovis, C., Martins, C. J. A. P., Mehner, A., Micela, G., Molaro, P., Mounzer, D., Nunes, N. J., Sozzetti, A., Mascareño, A. Suárez, and Udry, S.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
High-resolution spectroscopy studies of ultra-hot Jupiters have been key in our understanding of exoplanet atmospheres. Observing into the atmospheres of these giant planets allows for direct constraints on their atmospheric compositions and dynamics while laying the groundwork for new research regarding their formation and evolution environments. Two of the most well-studied ultra-hot Jupiters are WASP-76b and WASP-121b, with multiple detected chemical species and strong signatures of their atmospheric dynamics. We take a new look at these two exceptional ultra-hot Jupiters by reanalyzing the transit observations taken with ESPRESSO at the Very Large Telescope and attempt to detect additional species. To extract the planetary spectra of the two targets, we corrected for the telluric absorption and removed the stellar spectrum contributions. We then exploited new synthetic templates that were specifically designed for ultra-hot Jupiters in combination with the cross-correlation technique to unveil species that remained undetected by previous analyses. We add a novel detection of Ba+ to the known atmospheric compositions of WASP-76b and WASP-121b, the heaviest species detected to date in any exoplanetary atmosphere, with additional new detections of Co and Sr+ and a tentative detection of Ti+ for WASP-121b. We also confirm the presence of Ca+, Cr, Fe, H, Li, Mg, Mn, Na, and V on both WASP-76b and WASP-121b, with the addition of Ca, Fe+, and Ni for the latter. Finally, we also confirm the clear asymmetric absorption feature of Ca+ on WASP-121b, with an excess absorption at the bluer wavelengths and an effective planet radius beyond the Roche lobe. This indicates that the signal may arise from the escape of planetary atmosphere., Comment: 21 pages, 16 figures. Published in A&A Volume 666, October 2022 - Letter to the Editor
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- 2022
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73. Spatial Analysis of Chemical and Textural Soil Attributes in a Multistrata Agroforestry System
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Anelise Dias, Emanuel José Gomes de Araújo, Eduardo Vinicius da Silva, Pedro Vaz, Maryna Barbosa Ferreira, Thiago Lisboa Xavier, and Rafaella de Angeli Curto
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Spatial models ,kriging ,soil conservation ,sustainability ,agroecology ,Forestry ,SD1-669.5 - Abstract
Abstract The objective was to evaluate the spatial distribution of chemical and textural soil variables in a multistrata agroforestry system. A total of 73 georeferenced soil samples were collected at depths of 10-20 cm and 20-40 cm. The studied parameters were: pH H2O , potential acidity (H+Al), calcium (Ca 2+ ), magnesium (Mg 2+ ), aluminum (Al 3+ ), sodium (Na + ), potassium (K + ), phosphorus (P), organic carbon (C org ), cation exchange capacity (T-value), base saturation (V-value), total clay, total sand, and silt. Principal component analysis (PCA) was performed in R software using the FactoMineR and Factoextra packages. For variables with spatial dependence, ordinary kriging was performed using the best-fitted model. For variables without spatial dependence, inverse distance weighted (IDW) interpolation was applied (power = 2). The spherical model was the best fit for chemical attributes. IDW interpolation accurately mapped the textural attributes. It was concluded that geostatistics enabled a detailed analysis of chemical and textural attributes.
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- 2024
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74. Unlocking Nile tilapia (Oreochromis niloticus Linn., 1758) selective breeding programmes in Uganda through geographical genetic structure mapping
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Papius Dias Tibihika, Cassius Aruho, Victoria Namulawa, Richard Ddungu, Gertrude Atukunda, Margaret Aanyu, Mujibu Nkambo, Thapasya Vijayan, Gerald Kwikiriza, Manuel Curto, and Harald Meimberg
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genetic structure ,major lakes of Uganda ,Nile tilapia ,selective breeding programmes ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
Abstract Nile tilapia (Oreochromis niloticus), native to Africa and the Levant, is an important species for both aquaculture and capture fisheries. Despite these attributes, Nile tilapia has been negatively impacted by anthropogenic activities ranging from overfishing and habitat destruction to translocations. These human‐mediated activities have threatened the genetic evolutionary integrity of native populations of Nile tilapia and congeneric species through admixture, demographic bottlenecks and introgressive hybridization. In this context, the genetic contrast between farmed/bred strains and wild Nile tilapia populations in the major lakes of Uganda remains understudied. Understanding the genetic structure of Nile tilapia populations in the major water bodies of Uganda (lakes Victoria, Kyoga, Edward, George, Albert and Nile River) is a key resource to guide selective breeding programmes, thus minimizing the effects of maladaptation under both aquaculture and natural stocks. Although the population genetics of Nile tilapia in Uganda's major lakes have been studied, this was based on limited sampling scope, especially in the wild, and the key information on the species could have been overlooked. We fill this knowledge gap by genotyping 756 Nile tilapia individuals from multiple populations for each major water body of Uganda using a panel of 34 microsatellite loci based on the microsatellite genotyping‐by‐sequencing (SSR‐GBS) technique. The results indicate two discrete gene pools/stocks: the Edward‐George system and the Albert‐Kyoga system‐Victoria. Evidence of loss of genetic diversity and admixture of some Nile tilapia stocks was found, most likely resulting from anthropogenic perturbations. This study contributes useful information key for understanding the potential Nile tilapia broodstock sources for selective breeding programmes, aimed at improving aquaculture production in Uganda.
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- 2024
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75. Development of a natural language processing pipeline for assessment of cardiovascular risk in myeloproliferative neoplasms
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Andrea Duminuco, Joshua Au Yeung, Raj Vaghela, Sukhraj Virdee, Claire Woodley, Susan Asirvatham, Natalia Curto‐Garcia, Priya Sriskandarajah, Jennifer O'Sullivan, Hugues deLavallade, Deepti Radia, Shahram Kordasti, Giuseppe Palumbo, Claire Harrison, and Patrick Harrington
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2024
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76. Novel 3D human trophoblast culture to explore T. cruzi infection in the placenta
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Sofia Apodaca, Marco Di Salvatore, Arturo Muñoz-Calderón, María de los Ángeles Curto, Silvia A. Longhi, and Alejandro G. Schijman
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congenital Chagas disease ,placental tropism ,human trophoblast ,three-dimensional microtissue model ,Trypanosoma cruzi infection ,quantitative PCR ,Microbiology ,QR1-502 - Abstract
IntroductionHuman trophoblastic cell lines, such as BeWo, are commonly used in 2D models to study placental Trypanosoma cruzi infections. However, these models do not accurately represent natural infections. Three-dimensional (3D) microtissue cultures offer a more physiologically relevant in vitro model, mimicking tissue microarchitecture and providing an environment closer to natural infections. These 3D cultures exhibit functions such as cell proliferation, differentiation, morphogenesis, and gene expression that resemble in vivo conditions.MethodsWe developed a 3D culture model using the human trophoblastic cell line BeWo and nonadherent agarose molds from the MicroTissues® 3D Petri Dish® system. Both small (12–256) and large (12–81) models were tested with varying initial cell numbers. We measured the diameter of the 3D cultures and evaluated cell viability using Trypan Blue dye. Trophoblast functionality was assessed by measuring β-hCG production via ELISA. Cell fusion was evaluated using confocal microscopy, with Phalloidin or ZO-1 marking cell edges and DAPI staining nuclei. T. cruzi infection was assessed by microscopy and quantitative PCR, targeting the EF1-α gene for T. cruzi and GAPDH for BeWo cells, using three parasite strains: VD (isolated from a congenital Chagas disease infant and classified as Tc VI), and K98 and Pan4 (unrelated to congenital infection and classified as Tc I).ResultsSeeding 1000 BeWo cells per microwell in the large model resulted in comparable cellular viability to 2D cultures, with a theoretical diameter of 408.68 ± 12.65 μm observed at 5 days. Functionality, assessed through β-hCG production, exceeded levels in 2D cultures at both 3 and 5 days. T. cruzi infection was confirmed by qPCR and microscopy, showing parasite presence inside the cells for all three tested strains. The distribution and progression of the infection varied with each strain.DiscussionThis innovative 3D model offers a simple yet effective approach for generating viable and functional cultures susceptible to T. cruzi infection, presenting significant potential for studying the placental microenvironment.
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- 2024
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77. Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic
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Mariona Ramos, Rebeca Martín-García, M. Ángeles Curto, Laura Gómez-Delgado, M. Belén Moreno, Mamiko Sato, Elvira Portales, Masako Osumi, Sergio A. Rincón, Pilar Pérez, Juan C. Ribas, and Juan C.G. Cortés
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Functional aspects of cell biology ,Mycology ,Organizational aspects of cell biology ,Science - Abstract
Summary: Rod-shaped fission yeast grows through cell wall expansion at poles and septum, synthesized by essential glucan synthases. Bgs1 synthesizes the linear β(1,3)glucan of primary septum at cytokinesis. Linear β(1,3)glucan is also present in the wall poles, suggesting additional Bgs1 roles in growth polarity. Our study reveals an essential collaboration between Bgs1 and Tea1-Tea4, but not other polarity factors, in controlling growth polarity. Simultaneous absence of Bgs1 function and Tea1-Tea4 causes complete loss of growth polarity, spread of other glucan synthases, and spherical cell formation, indicating this defect is specifically due to linear β(1,3)glucan absence. Furthermore, linear β(1,3)glucan absence induces actin patches delocalization and sterols spread, which are ultimately responsible for the growth polarity loss without Tea1-Tea4. This suggests strong similarities in Bgs1 functions controlling actin structures during cytokinesis and polarized growth. Collectively, our findings unveil that cell wall β(1,3)glucan regulates polarized growth, like the equivalent extracellular matrix in neuronal cells.
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- 2024
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78. Hacia el auto sacramental: los autos alegóricos en las visiones de Juana de la Cruz (1481-1534)
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María Victoria Curto Hernández and Rebeca Sanmartín Bastida
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Castilla ,Baja Edad Media ,Renacimiento ,Literatura visionaria femenina ,Teatralidad ,Autos alegóricos ,Language and Literature - Abstract
Este trabajo tiene como objetivo profundizar en la teatralidad de los sermones de la visionaria franciscana Juana de la Cruz (1481-1534). Para ello se mostrará cómo las diferentes formas de teatralidad que presentan sus visiones celestiales pueden proporcionarnos indicios sobre el desarrollo del teatro religioso castellano de su tiempo. Se incluye también la edición dramatizada de un posible auto contenido en su obra Libro del conorte.
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- 2024
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79. Preclinical prototype validation and characterization of a thermobrachytherapy system for interstitial hyperthermia and high-dose-rate brachytherapy
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Ioannis Androulakis, Rob M.C. Mestrom, Sergio Curto, Inger-Karine K. Kolkman-Deurloo, and Gerard C. van Rhoon
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Brachytherapy ,Electromagnetic heating ,Hyperthermia ,Radiation therapy ,Validation ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and purpose: Integrating simultaneous interstitial hyperthermia in high-dose-rate brachytherapy treatments (HDR-BT) is expected to lead to enhanced therapeutic effect. However, there is currently no device available for such an integration. In this study, we presented and validated the thermobrachytherapy (TBT) preclinical prototype system that is able to seamlessly integrate into the HDR-BT workflow. Materials and methods: The TBT system consisted of an advanced radiofrequency power delivery and control system, dual-function interstitial applicators, and integrated connection and impedance matching system. The efficiency and minimum heating ability of the system was calculated performing calorimetric experiments. The effective-heating-length and heating pattern was evaluated using single-applicator split phantom experiments. The heating independence between applicators, the ability of the system to adaptable and predictable temperature steering was evaluated using multi-applicator split phantom experiments. Results: The system satisfied interstitial hyperthermia requirements. It demonstrated 50 % efficiency and ability to reach 6 °C temperature increase in 6 min. Effective-heating-length of the applicator was 43.7 mm, following the initial design. Heating pattern interference between applicators was lower than recommended. The system showed its ability to generate diverse heating patterns by adjusting the phase and amplitude settings of each electrode, aligning well with simulations (minimum agreement of 88 %). Conclusions: The TBT preclinical prototype system complied with IHT requirements, and agreed well with design criteria and simulations, hence performing as expected. The preclinical prototype TBT system can now be scaled to an in-vivo validation prototype, including an adaptable impedance matching solution, appropriate number of channels, and ensuring biocompatibility and regulatory compliance.
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- 2024
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80. Are AI systems biased against the poor? A machine learning analysis using Word2Vec and GloVe embeddings.
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Georgina Curto, Mario Fernando Jojoa Acosta, Flavio Comim, and Begoña García Zapirain
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- 2024
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81. Diversity of Emergent Dynamics in Competitive Threshold-Linear Networks.
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Katherine Morrison, Anda Degeratu, Vladimir Itskov, and Carina Curto
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- 2024
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82. A Recursive approach to the matrix moment problem
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Curto, R., Ech-charyfy, A., Idrissi, K., and Zerouali, E. H.
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Mathematics - Functional Analysis ,44A60 (primary), 47A57 (secondary) - Abstract
In this paper, we study the truncated matrix moment problem in one variable through recursive matrix extensions. \ We give necessary and sufficient conditions for a recursive matrix extension of finite data to be a matrix moment sequence in the classical cases of Hamburger, Stieltjes, and Hausdorff moment problems. \ We also discuss matricial subnormal completion and matricial $k$--hyponormal completion problems and provide an analog of Stampfli's Theorem on flat propagation for $2$--hyponormal matricial weighted shifts., Comment: 27 pages
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- 2022
83. J\'org Eschmeier's mathematical work
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Albrecht, Ernst, Curto, Raúl E., Hartz, Michael, and Putinar, Mihai
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Mathematics - History and Overview ,Mathematics - Functional Analysis - Abstract
An outline of J\"org Eschmeier's main mathematical contributions is organized both on a historical perspective, as well as on a few distinct topics. The reader can grasp from our essay the dynamics of spectral theory of commutative tuples of linear operators during the last half century. Some clear directions of future research are also underlined., Comment: 13 pages, 5 pictures
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- 2022
84. Front Matter
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
85. Subculture or Pop Culture? Theatre, Fashion, and Air Guitar
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
86. Trauma from a Safe Distance: The Unprecedented Success of The History of the Troubles (Accordin' to My Da)
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
87. Cover
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
88. Pugilists, Ponies, and Propriety: A Micro-History of Popular Athleticism at the Local Opera House
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
89. Staging Black Popularity: One Night in Miami and the Historic Hampton House
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
90. The Popularity of Contemporary Singaporean Pantomime
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
91. Performing Pilgrimage: Popular Religious Education at Chautauqua's Palestine Park
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
92. Promoting a Popular Body: The Stage, Couture, and the Creation of the Female Form in the Late Nineteenth and Early Twentieth Centuries
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
93. Popular Performance and Everyday Life: Interdisciplinary Transnational Dispatches from the Street and Sea
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
94. Unpopular Populism: Project 400 Theater's LES Travesti
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
95. Ndangered Narratives: Ernie McClintock as an Early Facilitator of Hip-Hop Theatre
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
96. Introduction
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
97. Ethos Statement
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Woodworth, Chris, Taylor, Chelsea, Stalter-Pace, Sunny, Owicki, Eleanor, McCarroll, Sarah, Kazuschyk, Kyla, Fish, Tom, Davis, Janet M., Curto, Chelsea, Cizmar, Elizabeth M., Bringardner, Chase, and Anderson, Mysia
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- 2024
98. Dielectric properties of low moisture foods measured by open-ended coaxial probe and cavity perturbation technique
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Frabetti, A. C. C., Garnault, T., Curto, H., Thillier, A., Boillereaux, L., Rouaud, O., and Curet, S.
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- 2023
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99. Jan Stochel, a stellar mathematician
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Sameer Chavan, Raúl Curto, Zenon Jan Jabłoński, Il Bong Jung, and Mihai Putinar
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unbounded subnormal operator ,moment problem ,composition operator ,cauchy dual ,Applied mathematics. Quantitative methods ,T57-57.97 - Abstract
The occasion for this survey article was the 70th birthday of Jan Stochel, professor at Jagiellonian University, former head of the Chair of Functional Analysis and a prominent member of the Kraków school of operator theory. In the course of his mathematical career, he has dealt, among other things, with various aspects of functional analysis, single and multivariable operator theory, the theory of moments, the theory of orthogonal polynomials, the theory of reproducing kernel Hilbert spaces, and mathematical aspects of quantum mechanics.
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- 2024
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100. Evaluación de los costes asociados a la enfermedad de pacientes con linfoma cutáneo de células T en España: análisis en función del estadio clínico (estudio MICADOS)
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B. Navarro Matilla, P.L. Ortiz Romero, R.M. Pujol Vallverdú, A. Combalia Escudero, I. Zapata Paz, E. González Barca, C. Muniesa Montserrat, M. Morillo Andújar, A. Pérez Ferriols, C. Román Curto, R. Fernández de Misa Cabrera, M. Hospital Gil, A. Marín Niebla, P.J. Rios Rull, F. de la Cruz Vicente, R.M. Izu Belloso, A. Martín García-Sancho, M.E. Parera Amer, R. Córdoba Mascuñano, M.D. Ramón Quiles, A. Saus Carreres, R. del Campo García, S. Machan, P. Viguera Ester, and J. Blanco Garnelo
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Mycosis fungoides ,Sézary syndrome ,Cost of disease ,Pharmacoeconomics ,Dermatology ,RL1-803 ,Internal medicine ,RC31-1245 - Abstract
Resumen: Antecedentes y objetivo: No se dispone de datos españoles sobre el coste asociado al linfoma cutáneo de células T (LCCT). Además, la incorporación de nuevos tratamientos hace necesario analizar el coste real de la enfermedad. El estudio MICADOS analizó dos objetivos principales: Por un lado, evaluó el impacto en la calidad de vida en los pacientes con LCCT, y por otro lado, estudió los costes de la enfermedad. En esta publicación se recoge el segundo de los objetivos del estudio. Métodos: El coste de la enfermedad se estudió bajo la perspectiva del Sistema Nacional de Salud (SNS) con un horizonte temporal de un año. Participaron 23 dermatólogos y hematólogos de 15 hospitales públicos españoles. Se incluyeron pacientes adultos con LCCT del tipo micosis fungoide (MF) y síndrome de Sézary (SS). Resultados: Se incluyeron 141 pacientes, el 57,4% masculinos, con una edad media de 63,6 años (IC 95%: 61,4-65,7). Los costes directos anuales medios por pacientes del estudio fueron de 34.214€, siendo de 11.952,47€ en estadio I, 23.506,21€ en estadio II, 38.771,81€ en estadio III y 72.748,84€ en estadio IV. El coste anual directo total estimado de todos los pacientes en España con MF/SS resultó en 78.301.171€, donde el 81% de los costes fueron atribuibles a pacientes en estadio I, el 7% al estadio II, el 6% al estadio III y el 6% al estadio IV. Conclusiones: Este estudio ofrece una evaluación precisa del coste directo del LCCT en pacientes con MF/SS en España, mostrando costes que varían sustancialmente en función del estadio. Los costes soportados por el paciente y los costes indirectos deberán considerarse en futuras investigaciones. Abstract: Background and objective: The cost of treating cutaneous T-cell lymphoma (CTCL) in Spain is unknown. With the advent of new treatments, it is more important than ever to gain an accurate picture of the true costs involved. The MICADOS study had 2 primary objectives: 1) to evaluate the impact of CTCL on patient quality of life, and 2) to evaluate the costs associated with the disease. This article reports the results of the cost analysis. Methods: We estimated the cost of treating CTCL over a period of 1 year from the perspective of the Spanish National Health System. Twenty-three dermatologists and hematologists from 15 public hospitals analyzed data for adult patients with mycosis fungoides (MF) or Sézary syndrome (SS). Results: A total of 141 patients (57.4% male) with a mean age of 63.6 years (95% CI: 61.4-65.7 years) were included. The mean direct annual cost of treating CTCL was €34,214 per patient. The corresponding costs by stage were €11,952.47 for stage I disease, €23,506.21 for stage II disease, €38,771.81 for stage III disease, and €72,748.84 for stage IV disease. The total direct annual cost of treating MF/SS in public hospitals in Spain was estimated at €78,301,171; stage I disease accounted for 81% of all costs, stage II for 7%, and stages III and IV for 6% each. Conclusions: The MICADOS study offers an accurate picture of the direct cost of treating CTCL in patients with MF/SS in Spain and shows that costs vary significantly according to disease stage. Patient-borne and indirect costs should be analyzed in future studies.
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- 2024
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