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716 results on '"Curtis, Bruce"'

82. Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs

Author

Curtis, Bruce A., Tanifuji, Goro, Burki, Fabien, Gruber, Ansgar, Irimia, Manuuel, Maruyama, Shinichiro, Arias, Maria C., Ball, Steven G., Gile, Gillian H., Hirakawa, Yoshihisa, Hopkins, Julia F., Kuo, Alan, Rensing, Stefan A., Schmutz, Jeremy, Symeonidi, Aikaterini, Elias, Marek, Eveleigh, Robert J. M., Herman, Emily K., Klute, Mary J., Nakayama, Takuro, Obornik, Miroslav, Reyes-Prieto, Adrian, Armbrust, E. Virginia, Aves, Stephen J., Beiko, Robert G., Coutinho, Pedro, Dacks, Joel B., Durnford, Dion G., Fast, Naomi M., Green, Beverley R., Grisdale, Cameron J., Hempel, Franziska, Henrissat, Bernard, Hoppner, Marc P., Ishida, Ken-Ichiro, Kim, Eunsoo, Koreny, Ludek, Kroth, Peter G., Liu, Yuan, Malik, Shehre-Banoo, Maier, Uwe G., McRose, Darcy, Mock, Thomas, Neilson, Jonathan A. D., Onodera, Naoko T., Poole, Anthony M., Pritham, Ellen J., Richards, Thomas A., Rocap, Gabrielle, Roy, Scott W., Sarai, Chihiro, Schaack, Sarah, Shirato, Shu, Slamovits, Claudio H., Spencer, Davie F., Suzuki, Shigekatsu, Worden, Alexandra Z., Zauner, Stefan, Barry, Kerrie, Bell, Callum, Bharti, Arvind K., Crow, John A., Grimwood, Jane, Kramer, Robin, Lindquist, Erika, Lucas, Susan, Salamov, Asaf, McFadden, Geoffrey I., Lane, Christopher E., Keeling, Patrick J., Gray, Michael W., Grigoriev, Igor V., and Archibald, John M.

Subjects
comparative genomics
Abstract

Cryptophyte and chlorarachniophyte algae are transitional forms in the widespread secondary endosymbiotic acquisition of photosynthesis by engulfment of eukaryotic algae. Unlike most secondary plastid-bearing algae, miniaturized versions of the endosymbiont nuclei (nucleomorphs) persist in cryptophytes and chlorarachniophytes. To determine why, and to address other fundamental questions about eukaryote eukaryote endosymbiosis, we sequenced the nuclear genomes of the cryptophyte Guillardia theta and the chlorarachniophyte Bigelowiella natans. Both genomes have 21,000 protein genes and are intron rich, and B. natans exhibits unprecedented alternative splicing for a single-celled organism. Phylogenomic analyses and subcellular targeting predictions reveal extensive genetic and biochemical mosaicism, with both host- and endosymbiont-derived genes servicing the mitochondrion, the host cell cytosol, the plastid and the remnant endosymbiont cytosol of both algae. Mitochondrion-to-nucleus gene transfer still occurs in both organisms but plastid-to-nucleus and nucleomorph-to-nucleus transfers do not, which explains why a small residue of essential genes remains locked in each nucleomorph.

Published
2012

86. Extreme mitochondrial reduction in a novel group of free-living metamonads

Author

Williams, Shelby K., Jerlström-Hultqvist, Jon, Eglit, Yana, Salas-Leiva, Dayana E., Curtis, Bruce, Orr, Russell, Stairs, Courtney W., Simpson, Alastair G. B., Roger, Andrew J., Williams, Shelby K., Jerlström-Hultqvist, Jon, Eglit, Yana, Salas-Leiva, Dayana E., Curtis, Bruce, Orr, Russell, Stairs, Courtney W., Simpson, Alastair G. B., and Roger, Andrew J.

Abstract

Metamonads are a diverse group of heterotrophic microbial eukaryotes adapted to living in hypoxic environments. All metamonads but one harbour metabolically altered ‘mitochondrion-related organelles’ (MROs) with reduced functions relative to aerobic mitochondria, however the degree of reduction varies markedly over the metamonad tree. To further investigate metamonad MRO diversity, we generated high quality draft genomes, transcriptomes, and predicted proteomes for five recently discovered free-living metamonads. Phylogenomic analyses place these organisms in a clade sister to the Fornicata – a group of metamonads that includes parasitic and free-living diplomonads and Carpediemonas-like organisms. Extensive bioinformatic analyses of the manually curated gene models showed that these organisms have extremely reduced MROs in comparison to other free-living metamonads. Loss of the mitochondrial iron-sulfur cluster (ISC) assembly system in some organisms in this group appears to be linked to the acquisition in their common ancestral lineage of a SUF-like minimal system (SMS) Fe/S cluster pathway through lateral gene transfer (LGT). One of the isolates, named ‘RC’, appears to have undergone even more drastic mitochondrial reduction losing almost all other detectable MRO-related functions. The extreme mitochondrial reduction observed within this free-living anaerobic protistan clade is unprecedented and demonstrates that mitochondrial functions, under some conditions, can be almost completely lost even in free-living organisms.

Published
2023

88. The Complete Genome of the Crenarchaeon Sulfolobus solfataricus P2

Author

She, Qunxin, Singh, Rama K., Confalonieri, Fabrice, Zivanovic, Yvan, Allard, Ghislaine, Awayez, Mariana J., Clausen, Ib Groth, Curtis, Bruce A., De Moors, Anick, Erauso, Gael, Fletcher, Cynthia, Jong, Ineke Heikamp-de, Jeffries, Alex C., Kozera, Catherine J., Medina, Nadine, Peng, Xu, Thi-Ngoc, Hoa Phan, Redder, Peter, Schenk, Margaret E., Theriault, Cynthia, Tolstrup, Niels, Charlebois, Robert L., Doolittle, W. Ford, Duguet, Michel, Gaasterland, Terry, Garrett, Roger A., Ragan, Mark A., Sensen, Christoph W., and Van der Oost, John

Published
2001

89. The Performance-Based Research Fund, Gender and a Cultural Cringe

Author

Curtis, Bruce

Abstract

This article explores ways the Performance-based Research Fund (PBRF) produces gendered results and expresses a cultural cringe. It is argued that the research evaluation is fixated with being "world-class" at the expense of academic practice that focuses on New Zealand. In this context, disadvantage faced by female academics under the PBRF can be re-imagined as an exemplar of a broader experience faced by all New Zealand-trained and focused academics. At the same time, the PBRF has produced some embarrassing results for neoliberal policy-makers and somewhat empowers academics as arbiters of excellence by reifying elements of peer review.

Published
2016
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95. A unique symbiosome in an anaerobic single-celled eukaryote

Author

Jerlström-Hultqvist, Jon, primary, Gallot-Lavallée, Lucie, additional, Salas-Leiva, Dayana E., additional, Curtis, Bruce A., additional, Záhonová, Kristína, additional, Čepička, Ivan, additional, Stairs, Courtney W., additional, Pipaliya, Shweta, additional, Dacks, Joel B., additional, Archibald, John M., additional, and Roger, Andrew J., additional

Published
2023
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97. Editorial

Author

Curtis, Bruce

Published
2017

99. Editorial

Author

Curtis, Bruce

Published
2018

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