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53. Guidelines for neuromuscular ultrasound training

Author

Tawfik, Eman A., primary, Cartwright, Michael S., additional, Grimm, Alexander, additional, Boon, Andrea J., additional, Kerasnoudis, Antonios, additional, Preston, David C., additional, Wilder‐Smith, Einar, additional, Axer, Hubertus, additional, Hobson‐Webb, Lisa D., additional, Alfen, Nens, additional, Crump, Nicholas, additional, Shahrizaila, Nortina, additional, Inkpen, Peter, additional, Mandeville, Ross, additional, Sakamuri, Sarada, additional, Shook, Steven J., additional, Shin, Susan, additional, and Walker, Francis O., additional

Published
2019
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54. Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Author

O’Byrne, Sorcha, primary, Elliott, Natalina, additional, Rice, Siobhan, additional, Buck, Gemma, additional, Fordham, Nicholas, additional, Garnett, Catherine, additional, Godfrey, Laura, additional, Crump, Nicholas T., additional, Wright, Gary, additional, Inglott, Sarah, additional, Hua, Peng, additional, Psaila, Bethan, additional, Povinelli, Benjamin, additional, Knapp, David J. H. F., additional, Agraz-Doblas, Antonio, additional, Bueno, Clara, additional, Varela, Ignacio, additional, Bennett, Phillip, additional, Koohy, Hashem, additional, Watt, Suzanne M., additional, Karadimitris, Anastasios, additional, Mead, Adam J., additional, Ancliff, Phillip, additional, Vyas, Paresh, additional, Menendez, Pablo, additional, Milne, Thomas A., additional, Roberts, Irene, additional, and Roy, Anindita, additional

Published
2019
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57. Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Author

O’Byrne, Sorcha, Elliott, Natalina, Rice, Siobhan, Buck, Gemma, Fordham, Nicholas, Garnett, Catherine, Godfrey, Laura, Crump, Nicholas T., Wright, Gary, Inglott, Sarah, Hua, Peng, Psaila, Bethan, Povinelli, Benjamin, Knapp, David J. H. F., Agraz-Doblas, Antonio, Bueno, Clara, Varela, Ignacio, Bennett, Phillip, Koohy, Hashem, Watt, Suzanne M., Karadimitris, Anastasios, Mead, Adam J., Ancliff, Phillip, Vyas, Paresh, Menéndez, Pablo, Milne, Thomas A., Roberts, Irene, Roy, Anindita, O’Byrne, Sorcha, Elliott, Natalina, Rice, Siobhan, Buck, Gemma, Fordham, Nicholas, Garnett, Catherine, Godfrey, Laura, Crump, Nicholas T., Wright, Gary, Inglott, Sarah, Hua, Peng, Psaila, Bethan, Povinelli, Benjamin, Knapp, David J. H. F., Agraz-Doblas, Antonio, Bueno, Clara, Varela, Ignacio, Bennett, Phillip, Koohy, Hashem, Watt, Suzanne M., Karadimitris, Anastasios, Mead, Adam J., Ancliff, Phillip, Vyas, Paresh, Menéndez, Pablo, Milne, Thomas A., Roberts, Irene, and Roy, Anindita

Abstract

Human lymphopoiesis is a dynamic lifelong process that starts in utero 6 weeks postconception. Although fetal B-lymphopoiesis remains poorly defined, it is key to understanding leukemia initiation in early life. Here, we provide a comprehensive analysis of the human fetal B-cell developmental hierarchy. We report the presence in fetal tissues of 2 distinct CD19+ B-progenitors, an adult-type CD10+ve ProB-progenitor and a new CD10-ve PreProB-progenitor, and describe their molecular and functional characteristics. PreProB-progenitors and ProB-progenitors appear early in the first trimester in embryonic liver, followed by a sustained second wave of B-progenitor development in fetal bone marrow (BM), where together they form >40% of the total hematopoietic stem cell/progenitor pool. Almost one-third of fetal B-progenitors are CD10-ve PreProB-progenitors, whereas, by contrast, PreProB-progenitors are almost undetectable (0.53% ± 0.24%) in adult BM. Single-cell transcriptomics and functional assays place fetal PreProB-progenitors upstream of ProB-progenitors, identifying them as the first B-lymphoid–restricted progenitor in human fetal life. Although fetal BM PreProB-progenitors and ProB-progenitors both give rise solely to B-lineage cells, they are transcriptionally distinct. As with their fetal counterparts, adult BM PreProB-progenitors give rise only to B-lineage cells in vitro and express the expected B-lineage gene expression program. However, fetal PreProB-progenitors display a distinct, ontogeny-related gene expression pattern that is not seen in adult PreProB-progenitors, and they share transcriptomic signatures with CD10-ve B-progenitor infant acute lymphoblastic leukemia blast cells. These data identify PreProB-progenitors as the earliest B-lymphoid–restricted progenitor in human fetal life and suggest that this fetal-restricted committed B-progenitor might provide a permissive cellular context for prenatal B-progenitor leukemia initiation.

Published
2019

73. Linear forecasting of the F10.7 proxy for solar activity.

Author

Warren, Harry P., Emmert, John T., and Crump, Nicholas A.

Abstract

The ability to accurately forecast variations in the solar extreme ultraviolet irradiance is important to many aspects of operational space weather. For example, variations in the Sun's radiative output at these wavelengths drive changes in thermospheric density, which perturbs the trajectories of objects in low Earth orbit. Thus, predicting the conjunction of an operational satellite with orbital debris requires accurate forecasts of solar activity. In this paper we present a simple linear forecasting model for the 10.7 cm radio flux ( F10.7), a commonly used proxy for solar activity. Comparisons with simple reference models indicate that this linear model has positive skill for all forecast days that we have considered. We also examine the impact of the F10.7 forecast skill on empirical model predictions of thermospheric density and ionospheric total electron content. [ABSTRACT FROM AUTHOR]

Published
2017
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75. Cover Picture: Live‐Cell Studies of p300/CBP Histone Acetyltransferase Activity and Inhibition (ChemBioChem 14/2012)

Author

Dancy, Beverley M., primary, Crump, Nicholas T., additional, Peterson, Daniel J., additional, Mukherjee, Chandrani, additional, Bowers, Erin M., additional, Ahn, Young‐Hoon, additional, Yoshida, Minoru, additional, Zhang, Jin, additional, Mahadevan, Louis C., additional, Meyers, David J., additional, Boeke, Jef D., additional, and Cole, Philip A., additional

Published
2012
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76. Live-Cell Studies of p300/CBP Histone Acetyltransferase Activity and Inhibition

Author

Dancy, Beverley M., primary, Crump, Nicholas T., additional, Peterson, Daniel J., additional, Mukherjee, Chandrani, additional, Bowers, Erin M., additional, Ahn, Young-Hoon, additional, Yoshida, Minoru, additional, Zhang, Jin, additional, Mahadevan, Louis C., additional, Meyers, David J., additional, Boeke, Jef D., additional, and Cole, Philip A., additional

Published
2012
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78. Stress-activated MAP Kinases in Chromatin and Transcriptional Complexes.

Author

Posas, Francesc, Nebreda, Angel R., Crump, Nicholas T., Han, Ya Ting, and Mahadevan, Louis C.

Abstract

Stress-activated MAP kinases (SAPKs) are activated by stressors or by certain physiological stimuli and mediate an intracellular response appropriate to the change in environment. Long-term adaptation requires reprogramming of transcription and one of the most significant actions of SAPK cascades is therefore induction of gene expression. SAPKs and their downstream kinases phosphorylate many chromatin-associated and transcription factors. Further, they can induce localised histone modification by regulating histone acetyltransferases and deacetylases. p38/SAPK2 also elicits phosphorylation of the nucleosomal proteins histone H3 and HMGN1 (previously HMG-14) via the downstream mitogen- and stress-stimulated kinases MSK1/2. Finally, recent evidence indicates a novel non-enzymatic SAPK function in transcriptional complexes, suggesting a more structural role. The yeast SAPK Hog1p is recruited to a proportion of its target genes on activation and localises beyond the promoter into coding regions. The observation that Hog1p interacts with elongating RNA polymerase II in addition to several transcriptional elongation factors has led to the suggestion that this SAPK may behave like an elongation factor at some target genes. The generality of this new function is discussed. [ABSTRACT FROM AUTHOR]

Published
2008
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