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51. MOESM1 of A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status

Author

Wollenberg, Kurt, Harris, Michael, Gabrielian, Andrei, Ciobanu, Nelly, Chesov, Dumitru, Long, Alyssa, Taaffe, Jessica, Hurt, Darrell, Rosenthal, Alex, Tartakovsky, Michael, and Crudu, Valeriu

Abstract

Additional file 1: Table S1. File containing data about paired samples analyzed in this article. These data include the SRA identifiers, TB Portal anonymized patient identifier, octal spoligotype, spoligotype and SNP barcode numerical lineage, pairwise distance (number of SNPs) between samples, days between sample collection, maximum drug resistance test result, case definition, case outcome, patient age at onset, and patient gender. A key to abbreviations used in the table are included in the header.

Published
2020
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52. Rapid Detection of Extensively Drug-Resistant Tuberculosis in Clinical Samples Using a Novel Tabletop Platform: Protocol for a Prospective Clinical Study (Preprint)

Author

Hillery, Naomi, primary, Seifert, Marva, additional, Catanzaro, Donald G, additional, McKinnon, Symone, additional, Colman, Rebecca E, additional, Chiles, Peter G, additional, Chesov, Dumitru, additional, Ciobanu, Nelly, additional, Hagan, Christopher, additional, Crudu, Valeriu, additional, Catanzaro, Antonino, additional, and Rodwell, Timothy C, additional

Published
2020
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57. A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.

Author

Wollenberg, Kurt, primary, Harris, Michael, additional, Gabrielian, Andrei, additional, Ciobanu, Nelly, additional, Chesov, Dumitru, additional, Long, Alyssa, additional, Taaffe, Jessica, additional, Hurt, Darrell, additional, Rosenthal, Alex, additional, Tartakovsky, Michael, additional, and Crudu, Valeriu, additional

Published
2019
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59. Prediction of multiple drug resistant pulmonary tuberculosis against drug sensitive pulmonary tuberculosis by CT nodular consolidation sign

Author

Huang, Xi-Ling, primary, Skrahin, Aliaksandr, additional, Lu, Pu-Xuan, additional, Alexandru, Sofia, additional, Crudu, Valeriu, additional, Astrovko, Andrei, additional, Skrahina, Alena, additional, Taaffe, Jessica, additional, Harris, Michael, additional, Long, Alyssa, additional, Wollenberg, Kurt, additional, Engle, Eric, additional, Hurt, Darrell E., additional, Akhundova, Irada, additional, Ismayilov, Sharafat, additional, Mammadbayov, Elcan, additional, Gadirova, Hagigat, additional, Abuzarov, Rafik, additional, Seyfaddinova, Mehriban, additional, Avaliani, Zaza, additional, Vashakidze, Sergo, additional, Shubladze, Natalia, additional, Nanava, Ucha, additional, Strambu, Irina, additional, Zaharia, Dragos, additional, Muntean, Alexandru, additional, Ghita, Eugenia, additional, Bogdan, Miron, additional, Mindru, Roxana, additional, Spinu, Victor, additional, Sora, Alexandra, additional, Ene, Catalina, additional, Sergueev, Eugene, additional, Kirichenko, Valery, additional, Lapitski, Vladzimir, additional, Snezhko, Eduard, additional, Kovalev, Vassili, additional, Tuzikov, Alexander, additional, Gabrielian, Andrei, additional, Rosenthal, Alex, additional, Tartakovsky, Michael, additional, and Wang, Yi Xiang J, additional

Published
2019
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60. Building a tuberculosis-free world: The Lancet Commission on tuberculosis

Author

Reid, Michael J A, primary, Arinaminpathy, Nimalan, additional, Bloom, Amy, additional, Bloom, Barry R, additional, Boehme, Catharina, additional, Chaisson, Richard, additional, Chin, Daniel P, additional, Churchyard, Gavin, additional, Cox, Helen, additional, Ditiu, Lucica, additional, Dybul, Mark, additional, Farrar, Jeremy, additional, Fauci, Anthony S, additional, Fekadu, Endalkachew, additional, Fujiwara, Paula I, additional, Hallett, Timothy B, additional, Hanson, Christy L, additional, Harrington, Mark, additional, Herbert, Nick, additional, Hopewell, Philip C, additional, Ikeda, Chieko, additional, Jamison, Dean T, additional, Khan, Aamir J, additional, Koek, Irene, additional, Krishnan, Nalini, additional, Motsoaledi, Aaron, additional, Pai, Madhukar, additional, Raviglione, Mario C, additional, Sharman, Almaz, additional, Small, Peter M, additional, Swaminathan, Soumya, additional, Temesgen, Zelalem, additional, Vassall, Anna, additional, Venkatesan, Nandita, additional, van Weezenbeek, Kitty, additional, Yamey, Gavin, additional, Agins, Bruce D, additional, Alexandru, Sofia, additional, Andrews, Jason R, additional, Beyeler, Naomi, additional, Bivol, Stela, additional, Brigden, Grania, additional, Cattamanchi, Adithya, additional, Cazabon, Danielle, additional, Crudu, Valeriu, additional, Daftary, Amrita, additional, Dewan, Puneet, additional, Doepel, Laurie K, additional, Eisinger, Robert W, additional, Fan, Victoria, additional, Fewer, Sara, additional, Furin, Jennifer, additional, Goldhaber-Fiebert, Jeremy D, additional, Gomez, Gabriela B, additional, Graham, Stephen M, additional, Gupta, Devesh, additional, Kamene, Maureen, additional, Khaparde, Sunil, additional, Mailu, Eunice W, additional, Masini, Enos O, additional, McHugh, Lorrie, additional, Mitchell, Ellen, additional, Moon, Suerie, additional, Osberg, Michael, additional, Pande, Tripti, additional, Prince, Lea, additional, Rade, Kirankumar, additional, Rao, Raghuram, additional, Remme, Michelle, additional, Seddon, James A, additional, Selwyn, Casey, additional, Shete, Priya, additional, Sachdeva, Kuldeep S, additional, Stallworthy, Guy, additional, Vesga, Juan F, additional, Vilc, Valentina, additional, and Goosby, Eric P, additional

Published
2019
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64. Clinical Management of Multidrug-Resistant Tuberculosis in 16 European Countries

Author

Günther, Gunar, primary, van Leth, Frank, additional, Alexandru, Sofia, additional, Altet, Neus, additional, Avsar, Korkut, additional, Bang, Didi, additional, Barbuta, Raisa, additional, Bothamley, Graham, additional, Ciobanu, Ana, additional, Crudu, Valeriu, additional, Danilovits, Manfred, additional, Dedicoat, Martin, additional, Duarte, Raquel, additional, Gualano, Gina, additional, Kunst, Heinke, additional, de Lange, Wiel, additional, Leimane, Vaira, additional, McLaughlin, Anne-Marie, additional, Magis-Escurra, Cecile, additional, Muylle, Inge, additional, Polcová, Veronika, additional, Popa, Cristina, additional, Rumetshofer, Rudolf, additional, Skrahina, Alena, additional, Solodovnikova, Varvara, additional, Spinu, Victor, additional, Tiberi, Simon, additional, Viiklepp, Piret, additional, and Lange, Christoph, additional

Published
2018
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66. Reply: Benefit of the Shorter Multidrug-Resistant Tuberculosis Treatment Regimen in California and Modified Eligibility Criteria

Author

van Leth, Frank, primary, Günther, Gunar, additional, Hoffmann, Harald, additional, Lange, Christoph, additional, Alexandru, Sofia, additional, Altet, Neus, additional, Avsar, Korkut, additional, Bang, Didi, additional, Barbuta, Raisa, additional, Bothamley, Graham, additional, Ciobanu, Ana, additional, Crudu, Valeriu, additional, Danilovits, Manfred, additional, Dedicoat, Martin, additional, Duarte, Raquel, additional, Fréchet-Jachym, Mathilde, additional, Gualano, Gina, additional, Guglielmetti, Lorenzo, additional, Heyckendorf, Jan, additional, Kalsdorf, Barbara, additional, Kunst, Heinke, additional, de Lange, Wiel, additional, Le Dû, Damien, additional, Leimane, Vaira, additional, van Leth, Frank, additional, Macedo, Rita, additional, Magis-Escurra, Cecile, additional, McLaughlin, Anne-Marie, additional, Muylle, Inge, additional, Olaru, Ioana D., additional, Oliveira, Olena, additional, Polcová, Veronika, additional, Pontali, Emanuele, additional, Popa, Cristina, additional, Robert, Jérôme, additional, Rumetshofer, Rudolf, additional, Skrahina, Alena, additional, Solodovnikova, Varvara, additional, Spinu, Victor, additional, Tiberi, Simon, additional, Veziris, Nicolas, additional, and Viiklepp, Piret, additional

Published
2017
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68. Multidrug-resistant tuberculosis in Moldova and the Former Yugoslav Republic of Macedonia: The importance of health system governance

Author

Thomas-Reilly, R. Gregory, Tozija, Fimka, Soltan, Viorel, Nikovska, Dance G, Crudu, Valeriu, Atun, Rifat, and McKee, Martin

Subjects
Europe, Health (social science), tuberculosis, Health Policy, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, MDR-TB, lcsh:RA1-1270, Moldova, health systems, The Former Yugoslav Republic of Macedonia, Drug-resistance, Europe, health systems, MDR-TB, Moldova, The Former Yugoslav Republic of Macedonia, tuberculosis, Drug-resistance
Abstract

Aim: Multidrug-resistant tuberculosis (MDR-TB) arises where treatment is interrupted or inadequate, when patients are treated inappropriately, or when an individual has impaired immune function, which can lead to a rapid progression from infection with an MDR-strain to disease. This study examines the role of health systems in amplifying or preventing the development of MDR-TB. Methods: We present two comparative studies, which were undertaken in The Former Yugoslav Republic of Macedonia (TFYR Macedonia) and Moldova. Results: The findings reveal several health systems-level factors that contribute to the different rates of MDR-TB observed in these two countries, including: pre-existing burden of disease; organization of the health system, with the existence of parallel systems; power dynamics among policy makers and disease programmes; and the accountability & effectiveness of programme oversight. Conclusions: The findings do not offer a universal template for health system reform but do identify specific factors that may be contributing to the epidemic and are worthy of further attention in the two countries., South Eastern European Journal of Public Health (SEEJPH), Volume V, 2016

Published
2016
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69. The TB Portals: an Open-Access, Web-Based Platform for Global Drug-Resistant-Tuberculosis Data Sharing and Analysis

Author

Rosenthal, Alex, primary, Gabrielian, Andrei, additional, Engle, Eric, additional, Hurt, Darrell E., additional, Alexandru, Sofia, additional, Crudu, Valeriu, additional, Sergueev, Eugene, additional, Kirichenko, Valery, additional, Lapitskii, Vladzimir, additional, Snezhko, Eduard, additional, Kovalev, Vassili, additional, Astrovko, Andrei, additional, Skrahina, Alena, additional, Taaffe, Jessica, additional, Harris, Michael, additional, Long, Alyssa, additional, Wollenberg, Kurt, additional, Akhundova, Irada, additional, Ismayilova, Sharafat, additional, Skrahin, Aliaksandr, additional, Mammadbayov, Elcan, additional, Gadirova, Hagigat, additional, Abuzarov, Rafik, additional, Seyfaddinova, Mehriban, additional, Avaliani, Zaza, additional, Strambu, Irina, additional, Zaharia, Dragos, additional, Muntean, Alexandru, additional, Ghita, Eugenia, additional, Bogdan, Miron, additional, Mindru, Roxana, additional, Spinu, Victor, additional, Sora, Alexandra, additional, Ene, Catalina, additional, Vashakidze, Sergo, additional, Shubladze, Natalia, additional, Nanava, Ucha, additional, Tuzikov, Alexander, additional, and Tartakovsky, Michael, additional

Published
2017
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72. Treatment outcomes of MDR-TB and HIV co-infection in Europe

Author

Magis-Escurra, Cecile, primary, Günther, Gunar, additional, Lange, Christoph, additional, Alexandru, Sofia, additional, Altet, Neus, additional, Avsar, Korkut, additional, Bang, Didi, additional, Barbuta, Raisa, additional, Bothamley, Graham, additional, Ciobanu, Ana, additional, Crudu, Valeriu, additional, Davilovits, Manfred, additional, Dedicoat, Martin, additional, Duarte, Raquel, additional, Gualano, Gina, additional, Kunst, Heike, additional, de Lange, Wiel, additional, Leimane, Vaira, additional, McLaughlin, Anne-Marie, additional, Muylle, Inge, additional, Polcová, Veronika, additional, Popa, Christina, additional, Rumetshofer, Rudolf, additional, Skrahina, Alena, additional, Solodovnikova, Varvara, additional, Spinu, Victor, additional, Tiberi, Simon, additional, Viiklepp, Piret, additional, and van Leth, Frank, additional

Published
2017
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73. FATE: the new partnership to Fight Against TB in Central and Eastern Europe

Author

Jagielski, Tomasz, primary, Aleksa, Alena, additional, Bachiyska, Elizabeta, additional, Bakos, Ágnes, additional, Crudu, Valeriu, additional, Dziadek, Jaroslaw, additional, Homolka, Jirí, additional, Homorodean, Daniela, additional, Jansone, Inta, additional, Katalinic-Jankovic, Vera, additional, Krenke, Rafal, additional, Kuzmic, Uroš, additional, Mokrousov, Igor, additional, Nikolayevskyy, Vlad, additional, Nikolenka, Alena, additional, Osmani, Gjyle Mulliqi, additional, Papaventsis, Dimitrios, additional, Pole, Ilva, additional, Porvazník, Igor, additional, Savic, Branislava, additional, Shubladze, Natalia, additional, Solovic, Ivan, additional, Szabó, Nóra, additional, Tafaj, Silva, additional, Ustamujic, Aida, additional, van Ingen, Jakko, additional, Vasiliauskiene, Edita, additional, Yablonsky, Peter K., additional, Zemanova, Ilona, additional, Zhuravlev, Viacheslav, additional, and Žolnir-Dovc, Manca, additional

Published
2017
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75. Accuracy of cobas MTB and MTB-RIF/INH for Detection of Mycobacterium tuberculosisand Drug Resistance

Author

de Vos, Margaretha, David, Anura, Duraisamy, Karthickeyan, Nadarajan, Darshaalini, Noroc, Ecaterina, Penn-Nicholson, Adam, Crudu, Valeriu, Giri, Sidhartha, Maurer, Florian P., Pati, Sanghamitra, Stevens, Wendy, Scott, Lesley, Turuk, Jyotimayee, Schumacher, Samuel G., Ruhwald, Morten, Ciobanu, Nelly, Singh Chadha, Sarabijt, Codreanu, Alexandru, Das, Dasarathi, Kahamba, Trish, Kar, Itishree, Macé, Aurélien, Mohanty, Jyoti, Nabeta, Pamela, Kranzer, Katherina, Ongarello, Stefano, Pattanaik, Archana, Romancenco, Elena, Sarin, Sanjay, Singh, Lyndel, Singh, Sunita, and Turcan, Nadia

Abstract

This study evaluated the performance of cobas MTB and cobas MTB-RIF/INH for the diagnosis of tuberculosis (TB) and detection of rifampicin (RIF) and isoniazid (INH) resistance. Adults presenting with pulmonary TB symptoms were recruited in South Africa, Moldova, and India. Performance of cobas MTB was assessed using culture as reference, whereas cobas MTB-RIF/INH was assessed using phenotypic drug susceptibility testing and whole-genome sequencing as composite reference standards. Xpert MTB/RIF (Xpert) or Xpert MTB/RIF Ultra (Ultra) was used as a comparator. The overall sensitivity and specificity of cobas MTB were 95% (95% CI, 93%–96%) and 96% (95% CI, 95%–97%), respectively. Among smear-negative results, the sensitivity of cobas MTB was 75% (95% CI, 66%–83%). Among participants tested with both cobas MTB and Xpert, sensitivity was 96% (95% CI, 94%–97%) for cobas MTB and 95% (95% CI, 93%–97%) for Xpert. Among participants tested with both cobas MTB and Ultra, sensitivity was 88% (95% CI, 81%–92%) for cobas MTB and 89% (95% CI, 83%–93%) for Ultra. Sensitivity and specificity of cobas MTB-RIF/INH for RIF and INH detection were 90% (95% CI, 84%–94%) and 100% (95% CI, 99%–100%), and 89% (95% CI, 84%–93%) and 99.5% (95% CI, 98%–100%), respectively. The cobas MTB and cobas MTB-RIF/INH assays exhibited high performance in a diverse population and present a suitable option for molecular detection of TB and both RIF and INH resistance.

Published
2024
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76. Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

Author

Lange, Christoph, Abubakar, Ibrahim, Alffenaar, Jan-Willem C, Bothamley, Graham, Caminero, Jose A, Carvalho, Anna Cristina C, Chang, Kwok-Chiu, Codecasa, Luigi, Correia, Ana, Crudu, Valeriu, Davies, Peter, Dedicoat, Martin, Drobniewski, Francis, Duarte, Raquel, Ehlers, Cordula, Erkens, Connie, Goletti, Delia, Günther, Gunar, Ibraim, Elmira, Kampmann, Beate, Kuksa, Liga, de Lange, Wiel, van Leth, Frank, van Lunzen, Jan, Matteelli, Alberto, Menzies, Dick, Monedero, Ignacio, Richter, Elvira, Rüsch-Gerdes, Sabine, Sandgren, Andreas, Scardigli, Anna, Skrahina, Alena, Tortoli, Enrico, Volchenkov, Grigory, Wagner, Dirk, van der Werf, Marieke J, Williams, Bhanu, Yew, Wing-Wai, Zellweger, Jean-Pierre, Cirillo, Daniela Maria, and TBNET

Abstract

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. This document summarises the current knowledge on the prevention, diagnosis and treatment of adults and children with MDR/XDR-TB and their contacts, and provides expert consensus recommendations on questions where scientific evidence is still lacking.

Published
2014

77. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Author

Stucki, David, primary, Brites, Daniela, additional, Jeljeli, Leïla, additional, Coscolla, Mireia, additional, Liu, Qingyun, additional, Trauner, Andrej, additional, Fenner, Lukas, additional, Rutaihwa, Liliana, additional, Borrell, Sonia, additional, Luo, Tao, additional, Gao, Qian, additional, Kato-Maeda, Midori, additional, Ballif, Marie, additional, Egger, Matthias, additional, Macedo, Rita, additional, Mardassi, Helmi, additional, Moreno, Milagros, additional, Vilanova, Griselda Tudo, additional, Fyfe, Janet, additional, Globan, Maria, additional, Thomas, Jackson, additional, Jamieson, Frances, additional, Guthrie, Jennifer L, additional, Asante-Poku, Adwoa, additional, Yeboah-Manu, Dorothy, additional, Wampande, Eddie, additional, Ssengooba, Willy, additional, Joloba, Moses, additional, Boom, W Henry, additional, Basu, Indira, additional, Bower, James, additional, Saraiva, Margarida, additional, Vasconcellos, Sidra E G, additional, Suffys, Philip, additional, Koch, Anastasia, additional, Wilkinson, Robert, additional, Gail-Bekker, Linda, additional, Malla, Bijaya, additional, Ley, Serej D, additional, Beck, Hans-Peter, additional, de Jong, Bouke C, additional, Toit, Kadri, additional, Sanchez-Padilla, Elisabeth, additional, Bonnet, Maryline, additional, Gil-Brusola, Ana, additional, Frank, Matthias, additional, Penlap Beng, Veronique N, additional, Eisenach, Kathleen, additional, Alani, Issam, additional, Ndung'u, Perpetual Wangui, additional, Revathi, Gunturu, additional, Gehre, Florian, additional, Akter, Suriya, additional, Ntoumi, Francine, additional, Stewart-Isherwood, Lynsey, additional, Ntinginya, Nyanda E, additional, Rachow, Andrea, additional, Hoelscher, Michael, additional, Cirillo, Daniela Maria, additional, Skenders, Girts, additional, Hoffner, Sven, additional, Bakonyte, Daiva, additional, Stakenas, Petras, additional, Diel, Roland, additional, Crudu, Valeriu, additional, Moldovan, Olga, additional, Al-Hajoj, Sahal, additional, Otero, Larissa, additional, Barletta, Francesca, additional, Carter, E Jane, additional, Diero, Lameck, additional, Supply, Philip, additional, Comas, Iñaki, additional, Niemann, Stefan, additional, and Gagneux, Sebastien, additional

Published
2016
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78. Treatment Outcomes in Multidrug-Resistant Tuberculosis

Author

Günther, Gunar, primary, Lange, Christoph, additional, Alexandru, Sofia, additional, Altet, Neus, additional, Avsar, Korkut, additional, Bang, Didi, additional, Barbuta, Raisa, additional, Bothamley, Graham, additional, Ciobanu, Ana, additional, Crudu, Valeriu, additional, Danilovits, Manfred, additional, Dedicoat, Martin, additional, Duarte, Raquel, additional, Gualano, Gina, additional, Kunst, Heinke, additional, de Lange, Wiel, additional, Leimane, Vaira, additional, Magis-Escurra, Cecile, additional, McLaughlin, Anne-Marie, additional, Muylle, Inge, additional, Polcová, Veronika, additional, Popa, Christina, additional, Rumetshofer, Rudolf, additional, Skrahina, Alena, additional, Solodovnikova, Varvara, additional, Spinu, Victor, additional, Tiberi, Simon, additional, Viiklepp, Piret, additional, and van Leth, Frank, additional

Published
2016
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79. Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study

Author

Colman, Rebecca E., primary, Anderson, Julia, additional, Lemmer, Darrin, additional, Lehmkuhl, Erik, additional, Georghiou, Sophia B., additional, Heaton, Hannah, additional, Wiggins, Kristin, additional, Gillece, John D., additional, Schupp, James M., additional, Catanzaro, Donald G., additional, Crudu, Valeriu, additional, Cohen, Ted, additional, Rodwell, Timothy C., additional, and Engelthaler, David M., additional

Published
2016
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81. In reply

Author

Merker, Matthias, primary, Crudu, Valeriu, additional, Noroc, Ecaterina, additional, Romancenco, Elena, additional, Chesov, Dumitru, additional, Günther, Gunar, additional, Niemann, Stefan, additional, and Lange, Christoph, additional

Published
2016
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82. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Author

Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael G.B., Rüsch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Béguec, Caroline, Antierens, Annick, Augustynowicz-Kopeć, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Barry, Clifton E., Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sébastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebæk, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Branislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, Vukovic, Dragana, Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael G.B., Rüsch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Béguec, Caroline, Antierens, Annick, Augustynowicz-Kopeć, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Barry, Clifton E., Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sébastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebæk, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Branislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, and Vukovic, Dragana

Abstract

Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.

Published
2015

83. BIOLOGICAL EVALUATION OF NEW 2-PHENETHYLBENZOYL THIOUREA DERIVATIVES AS ANTITUBERCULOSIS AGENTS.

Author

STRATAN, ECATERINA, ŢURCAN, NADEJDA, CRUDU, VALERIU, ROMANCENCO, ELENA, COTELEA, TAMARA, NIŢULESCU, GEORGE MIHAI, CHIRIŢĂ, CORNEL, and MORUŞCIAG, CHIRIŢĂ

Subjects
DRUG therapy for tuberculosis, THIOUREA, CHEMICAL derivatives, MYCOBACTERIUM tuberculosis, TOXICITY testing, LABORATORY mice
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018

84. Building a tuberculosis-free world: The LancetCommission on tuberculosis

Author

Reid, Michael J A, Arinaminpathy, Nimalan, Bloom, Amy, Bloom, Barry R, Boehme, Catharina, Chaisson, Richard, Chin, Daniel P, Churchyard, Gavin, Cox, Helen, Ditiu, Lucica, Dybul, Mark, Farrar, Jeremy, Fauci, Anthony S, Fekadu, Endalkachew, Fujiwara, Paula I, Hallett, Timothy B, Hanson, Christy L, Harrington, Mark, Herbert, Nick, Hopewell, Philip C, Ikeda, Chieko, Jamison, Dean T, Khan, Aamir J, Koek, Irene, Krishnan, Nalini, Motsoaledi, Aaron, Pai, Madhukar, Raviglione, Mario C, Sharman, Almaz, Small, Peter M, Swaminathan, Soumya, Temesgen, Zelalem, Vassall, Anna, Venkatesan, Nandita, van Weezenbeek, Kitty, Yamey, Gavin, Agins, Bruce D, Alexandru, Sofia, Andrews, Jason R, Beyeler, Naomi, Bivol, Stela, Brigden, Grania, Cattamanchi, Adithya, Cazabon, Danielle, Crudu, Valeriu, Daftary, Amrita, Dewan, Puneet, Doepel, Laurie K, Eisinger, Robert W, Fan, Victoria, Fewer, Sara, Furin, Jennifer, Goldhaber-Fiebert, Jeremy D, Gomez, Gabriela B, Graham, Stephen M, Gupta, Devesh, Kamene, Maureen, Khaparde, Sunil, Mailu, Eunice W, Masini, Enos O, McHugh, Lorrie, Mitchell, Ellen, Moon, Suerie, Osberg, Michael, Pande, Tripti, Prince, Lea, Rade, Kirankumar, Rao, Raghuram, Remme, Michelle, Seddon, James A, Selwyn, Casey, Shete, Priya, Sachdeva, Kuldeep S, Stallworthy, Guy, Vesga, Juan F, Vilc, Valentina, and Goosby, Eric P

Published
2019
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85. Out-patient MDR-TB care in Moldova

Author

Buga, Alexandru, primary, Crudu, Valeriu, additional, Domente, Liliana, additional, Dravniece, Gunta, additional, Tadolini, Marina, additional, Migliori, Giovanni Battista, additional, and Manissero, Davide, additional

Published
2015
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87. Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing

Author

Colman, Rebecca E., primary, Schupp, James M., additional, Hicks, Nathan D., additional, Smith, David E., additional, Buchhagen, Jordan L., additional, Valafar, Faramarz, additional, Crudu, Valeriu, additional, Romancenco, Elena, additional, Noroc, Ecaterina, additional, Jackson, Lynn, additional, Catanzaro, Donald G., additional, Rodwell, Timothy C., additional, Catanzaro, Antonino, additional, Keim, Paul, additional, and Engelthaler, David M., additional

Published
2015
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89. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Author

Merker, Matthias, primary, Blin, Camille, additional, Mona, Stefano, additional, Duforet-Frebourg, Nicolas, additional, Lecher, Sophie, additional, Willery, Eve, additional, Blum, Michael G B, additional, Rüsch-Gerdes, Sabine, additional, Mokrousov, Igor, additional, Aleksic, Eman, additional, Allix-Béguec, Caroline, additional, Antierens, Annick, additional, Augustynowicz-Kopeć, Ewa, additional, Ballif, Marie, additional, Barletta, Francesca, additional, Beck, Hans Peter, additional, Barry, Clifton E, additional, Bonnet, Maryline, additional, Borroni, Emanuele, additional, Campos-Herrero, Isolina, additional, Cirillo, Daniela, additional, Cox, Helen, additional, Crowe, Suzanne, additional, Crudu, Valeriu, additional, Diel, Roland, additional, Drobniewski, Francis, additional, Fauville-Dufaux, Maryse, additional, Gagneux, Sébastien, additional, Ghebremichael, Solomon, additional, Hanekom, Madeleine, additional, Hoffner, Sven, additional, Jiao, Wei-wei, additional, Kalon, Stobdan, additional, Kohl, Thomas A, additional, Kontsevaya, Irina, additional, Lillebæk, Troels, additional, Maeda, Shinji, additional, Nikolayevskyy, Vladyslav, additional, Rasmussen, Michael, additional, Rastogi, Nalin, additional, Samper, Sofia, additional, Sanchez-Padilla, Elisabeth, additional, Savic, Branislava, additional, Shamputa, Isdore Chola, additional, Shen, Adong, additional, Sng, Li-Hwei, additional, Stakenas, Petras, additional, Toit, Kadri, additional, Varaine, Francis, additional, Vukovic, Dragana, additional, Wahl, Céline, additional, Warren, Robin, additional, Supply, Philip, additional, Niemann, Stefan, additional, and Wirth, Thierry, additional

Published
2015
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90. FATE: the new partnership to Fight Against TB in Central and Eastern Europe

Author

Aleksa, Alena, Bachiyska, Elizabeta, Bakos, Ágnes, Crudu, Valeriu, Dziadek, Jaroslaw, Homolka, Jirí, Homorodean, Daniela, Jansone, Inta, Katalinic-Jankovic, Vera, Krenke, Rafal, Kuzmic, Uroš, Mokrousov, Igor, Nikolayevskyy, Vlad, Nikolenka, Alena, Osmani, Gjyle Mulliqi, Papaventsis, Dimitrios, Pole, Ilva, Porvazník, Igor, Savic, Branislava, Shubladze, Natalia, Solovic, Ivan, Szabó, Nóra, Tafaj, Silva, Ustamujic, Aida, van Ingen, Jakko, Vasiliauskiene, Edita, Yablonsky, Peter K., Zemanova, Ilona, Zhuravlev, Viacheslav, Žolnir-Dovc, Manca, and Jagielski, Tomasz

Published
2017
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92. Molecular Concepts of Macrophage Targeting

Author

Boldescu, Veaceslav, primary, Crudu, Valeriu, additional, Sucman, Natalia, additional, Pogrebnoi, Serghei, additional, Zviaghinţeva, Marina, additional, Stîngaci, Eugenia, additional, Pogrebnoi, Vsevolod, additional, and Macaev, Fliur, additional

Published
2013
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95. Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

Author

Manson, Abigail L, Cohen, Keira A, Abeel, Thomas, Desjardins, Christopher A, Armstrong, Derek T, Barry, Clifton E, Brand, Jeannette, Chapman, Sinéad B, Cho, Sang-Nae, Gabrielian, Andrei, Gomez, James, Jodals, Andreea M, Joloba, Moses, Jureen, Pontus, Lee, Jong Seok, Malinga, Lesibana, Maiga, Mamoudou, Nordenberg, Dale, Noroc, Ecaterina, Romancenco, Elena, Salazar, Alex, Ssengooba, Willy, Velayati, A A, Winglee, Kathryn, Zalutskaya, Aksana, Via, Laura E, Cassell, Gail H, Dorman, Susan E, Ellner, Jerrold, Farnia, Parissa, Galagan, James E, Rosenthal, Alex, Crudu, Valeriu, Homorodean, Daniela, Hsueh, Po-Ren, Narayanan, Sujatha, Pym, Alexander S, Skrahina, Alena, Swaminathan, Soumya, Van der Walt, Martie, Alland, David, Bishai, William R, Cohen, Ted, Hoffner, Sven, Birren, Bruce W, and Earl, Ashlee M

Abstract

Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we examined a data set of whole-genome sequences from 5,310 M. tuberculosis isolates from five continents. Despite the great diversity of these isolates with respect to geographical point of isolation, genetic background and drug resistance, the patterns for the emergence of drug resistance were conserved globally. We have identified harbinger mutations that often precede multidrug resistance. In particular, the katG mutation encoding p.Ser315Thr, which confers resistance to isoniazid, overwhelmingly arose before mutations that conferred rifampicin resistance across all of the lineages, geographical regions and time periods. Therefore, molecular diagnostics that include markers for rifampicin resistance alone will be insufficient to identify pre-MDR strains. Incorporating knowledge of polymorphisms that occur before the emergence of multidrug resistance, particularly katG p.Ser315Thr, into molecular diagnostics should enable targeted treatment of patients with pre-MDR-TB to prevent further development of MDR-TB.

Published
2017
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97. Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosisIsolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study

Author

Colman, Rebecca E., Anderson, Julia, Lemmer, Darrin, Lehmkuhl, Erik, Georghiou, Sophia B., Heaton, Hannah, Wiggins, Kristin, Gillece, John D., Schupp, James M., Catanzaro, Donald G., Crudu, Valeriu, Cohen, Ted, Rodwell, Timothy C., and Engelthaler, David M.

Abstract

ABSTRACTIncreasingly complex drug-resistant tuberculosis (DR-TB) is a major global health concern and one of the primary reasons why TB is now the leading infectious cause of death worldwide. Rapid characterization of a DR-TB patient's complete drug resistance profile would facilitate individualized treatment in place of empirical treatment, improve treatment outcomes, prevent amplification of resistance, and reduce the transmission of DR-TB. The use of targeted next-generation sequencing (NGS) to obtain drug resistance profiles directly from patient sputum samples has the potential to enable comprehensive evidence-based treatment plans to be implemented quickly, rather than in weeks to months, which is currently needed for phenotypic drug susceptibility testing (DST) results. In this pilot study, we evaluated the performance of amplicon sequencing of Mycobacterium tuberculosisDNA from patient sputum samples using a tabletop NGS technology and automated data analysis to provide a rapid DST solution (the Next Gen-RDST assay). One hundred sixty-six out of 176 (94.3%) sputum samples from the Republic of Moldova yielded complete Next Gen-RDST assay profiles for 7 drugs of interest. We found a high level of concordance of our Next Gen-RDST assay results with phenotypic DST (97.0%) and pyrosequencing (97.8%) results from the same clinical samples. Our Next Gen-RDST assay was also able to estimate the proportion of resistant-to-wild-type alleles down to mixtures of =1%, which demonstrates the ability to detect very low levels of resistant variants not detected by pyrosequencing and possibly below the threshold for phenotypic growth methods. The assay as described here could be used as a clinical or surveillance tool.

Published
2016
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98. MTBDRplusand MTBDRslAssays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis

Author

Seifert, Marva, Georghiou, Sophia B., Catanzaro, Donald, Rodrigues, Camilla, Crudu, Valeriu, Victor, Thomas C., Garfein, Richard S., Catanzaro, Antonino, and Rodwell, Timothy C.

Abstract

ABSTRACTAccurate identification of drug-resistant Mycobacterium tuberculosisis imperative for effective treatment and subsequent reduction in disease transmission. Line probe assays rapidly detect mutations associated with resistance and wild-type sequences associated with susceptibility. Examination of molecular-level performance is necessary for improved assay result interpretation and for continued diagnostic development. Using data collected from a large, multisite diagnostic study, probe hybridization results from line probe assays, MTBDRplusand MTBDRsl, were compared to those of sequencing, and the diagnostic performance of each individual mutation and wild-type probe was assessed. Line probe assay results classified as resistant due to the absence of wild-type probe hybridization were compared to those of sequencing to determine if novel mutations were inhibiting wild-type probe hybridization. The contribution of absent wild-type probe hybridization to the detection of drug resistance was assessed via comparison to a phenotypic reference standard. In our study, mutation probes demonstrated significantly higher specificities than wild-type probes and wild-type probes demonstrated marginally higher sensitivities than mutation probes, an ideal combination for detecting the presence of resistance conferring mutations while yielding the fewest number of false-positive results. The absence of wild-type probe hybridization without mutation probe hybridization was determined to be primarily the result of failure of mutation probe hybridization and not the result of novel or rare mutations. Compared to phenotypic culture-based drug susceptibility testing, the absence of wild-type probe hybridization without mutation probe hybridization significantly contributed to the detection of phenotypic rifampin and fluoroquinolone resistance with negligible increases in false-positive results.

Published
2016
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99. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage (vol 47, pg 242, 2015)

Author

Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael, Ruesch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Beguec, Caroline, Antierens, Annick, Augustynowicz-Kopec, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Clifton E Barry, Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sebastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei-Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebeak, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Ranislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li-Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, Vukovic, Dragana, Wahl, Celine, Warren, Robin, Supply, Philip, Niemann, Stefan, and Wirth, Thierry

100. Additional file 1: Table S1. of Shedding light on the performance of a pyrosequencing assay for drug-resistant tuberculosis diagnosis

Author

Georghiou, Sophia, Seifert, Marva, Shou-Yean Lin, Catanzaro, Donald, Garfein, Richard, Jackson, Roberta, Crudu, Valeriu, Rodrigues, Camilla, Victor, Thomas, Catanzaro, Antonino, and Rodwell, Timothy

Subjects
3. Good health
Abstract

Pyrosequencing (PSQ) Success of Each Gene Target by Smear- and Culture-Status. Table S2. Proportion of Successful Pyrosequencing (PSQ) Reactions by Smear- and Culture-Status. (DOCX 18 kb)

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