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407 results on '"Cree-Green, Melanie"'

52. Results from the Effects of MEtformin on cardiovasculaR function in AdoLescents with type 1 Diabetes (EMERALD) Study: A Brief Report of Kidney and Inflammatory Outcomes

Author

Tommerdahl, Kalie L., Bjornstad, Petter, Kendrick, Jessica, Cree-Green, Melanie, Baumgartner, Amy D., Pyle, Laura, Reusch, Jane E.B., and Nadeau, Kristen J.

Subjects
Diabetes Mellitus, Type 1, endocrine system diseases, Adolescent, Creatinine, nutritional and metabolic diseases, Albuminuria, Humans, Diabetic Nephropathies, Kidney, Article, Metformin, Glomerular Filtration Rate
Abstract

Youth with type 1 diabetes (T1D) demonstrate insulin resistance (IR), independent of glycemia, when compared to normoglycemic peers. IR increases the risk for cardiovascular disease (CVD) and diabetic kidney disease (DKD), factors also associated with systemic inflammation. We evaluated the effect of metformin on markers of inflammation and DKD in youth with T1D. EMERALD, a double-blind, randomized, placebo-controlled trial of 3 months of metformin in 48 youth aged 12-21 years with T1D, included baseline and follow-up assessments of serum creatinine and cystatin C to estimate glomerular filtration rate (eGFR), AST, ALT, highly sensitive c-reactive protein, white blood count, platelets, adiponectin, leptin, and urine albumin:creatinine ratio (UACR). Metformin was associated with a 13.9 mL/min/1.73m(2) (95% CI 4.7-23.1 mL/min/1.73m(2)) increase in eGFR by serum creatinine vs. placebo (p≤0.01), with a significant difference remaining after multivariable adjustments (p=0.03). Whereas eGFR measured by serum creatinine increased significantly following metformin, no differences were observed with cystatin C, UACR, or systemic inflammatory markers. Additional studies with directly measured GFR in response to metformin in T1D are needed.

Published
2020

53. Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and β-Cell Function.

Author

Xiang, Anny H., Martinez, Mayra P., Trigo, Enrique, Utzschneider, Kristina M., Cree‐Green, Melanie, Arslanian, Silva A., Ehrmann, David A., Caprio, Sonia, Mohamed, Passant H. I. H., Hwang, Darryl H., Katkhouda, Namir, Nayak, Krishna S., Buchanan, Thomas A., Cree-Green, Melanie, and RISE Consortium

Subjects
INSULIN sensitivity, GASTRIC banding, GASTRIC bypass, TYPE 2 diabetes, FAT, LIVER, ADULTS, CANAGLIFLOZIN, RESEARCH, BARIATRIC surgery, RESEARCH methodology, BLOOD sugar, MEDICAL cooperation, EVALUATION research, INSULIN, COMPARATIVE studies, STOMACH surgery, PREDIABETIC state, INSULIN resistance
Abstract

Objective: The aim of this study was to examine the relationship between changes in liver fat and changes in insulin sensitivity and β-cell function 2 years after gastric banding surgery.Methods: Data included 23 adults with the surgery who had prediabetes or type 2 diabetes for less than 1 year and BMI 30 to 40 kg/m2 at baseline. Body adiposity measures including liver fat content (LFC), insulin sensitivity (M/I), and β-cell responses (acute, steady-state, and arginine-stimulated maximum C-peptide) were assessed at baseline and 2 years after surgery. Regression models were used to assess associations adjusted for age and sex.Results: Two years after surgery, all measures of body adiposity, LFC, fasting and 2-hour glucose, and hemoglobin A1c significantly decreased; M/I significantly increased; and β-cell responses adjusted for M/I did not change significantly. Among adiposity measures, reduction in LFC had the strongest association with M/I increase (r = -0.61, P = 0.003). Among β-cell measures, change in LFC was associated with change in acute C-peptide response to arginine at maximal glycemic potentiation adjusted for M/I (r = 0.66, P = 0.007). Significant reductions in glycemic measures and increase in M/I were observed in individuals with LFC loss >2.5%.Conclusions: Reduction in LFC after gastric banding surgery appears to be an important factor associated with long-term improvements in insulin sensitivity and glycemic profiles in adults with obesity and prediabetes or early type 2 diabetes. [ABSTRACT FROM AUTHOR]

Published
2021
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58. Short Term Glucagon‐Like Peptide‐1 Receptor Agonist Therapy Does Not Influence Hepatic De Novo Lipogenesis in Polycystic Ovary Syndrome

Author

Stuppy, Jacob, primary, Severn, Cameron, additional, Parks, Elizabeth, additional, Wolfe, Robert, additional, Carreau, Anne‐Marie, additional, Garcia‐Reyes, Yesenia, additional, Rahat, Haseeb, additional, Wagner, David, additional, Nadeau, Kristen, additional, Pyle, Laura, additional, and Cree‐Green, Melanie, additional

Published
2021
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59. Combined Oral Contraceptive Treatment Does Not Alter the Gut Microbiome or Serum Metabolomic Profile in Obese Girls with Polycystic Ovary Syndrome

Author

Jobira, Beza, primary, Frank, Daniel N, additional, Silveira, Lori J, additional, Garcia-Reyes, Yesenia, additional, Robertson, Charles E, additional, Ir, Diana, additional, Alexander, Keisha L, additional, D’Alessandro, Angelo, additional, Nadeau, Kristen, additional, and Cree-Green, Melanie, additional

Published
2021
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61. Single‐leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes

Author

Scalzo, Rebecca L., primary, Schauer, Irene E., additional, Rafferty, Deirdre, additional, Knaub, Leslie A., additional, Kvaratskhelia, Nina, additional, Johnson, Taro Kaelix, additional, Pott, Gregory B., additional, Abushamat, Layla A., additional, Whipple, Mary O., additional, Huebschmann, Amy G., additional, Cree‐Green, Melanie, additional, Reusch, Jane E. B., additional, and Regensteiner, Judith G., additional

Published
2021
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62. RISE Clamp Method - Supplemental Tables

Author

Mather, Kieren J, Tjaden, Ashley, Hoehn, Adam, Nadeau, Kristen J, Buchanan, Tom, Kahn, Steven E, Arslanian, Silva, Caprio, Sonia, Atkinson, Karen, Cree-Green, Melanie, Utzschneider, Kristina, and Edelstein, Sharon E

Subjects
Glucose clamp, precision, accuracy, humanities
Abstract

Supplemental tables for a manuscript describing the approach and technical outcomes for a multi center study implementation of hyperglycemic glucose clamp methodology.

Published
2020
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65. Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes

Author

Tommerdahl, Kalie L., primary, Baumgartner, Karl, additional, Schäfer, Michal, additional, Bjornstad, Petter, additional, Melena, Isabella, additional, Hegemann, Shannon, additional, Baumgartner, Amy D., additional, Pyle, Laura, additional, Cree-Green, Melanie, additional, Truong, Uyen, additional, Browne, Lorna, additional, Regensteiner, Judith G., additional, Reusch, Jane E.B., additional, and Nadeau, Kristen J., additional

Published
2021
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79. Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism.

Author

Cree‐Green, Melanie, Wiromrat, Pattara, Stuppy, Jacob J., Thurston, Jessica, Bergman, Bryan C., Baumgartner, Amy D., Bacon, Samantha, Scherzinger, Ann, Pyle, Laura, Nadeau, Kristen J., and Cree-Green, Melanie

Subjects
CALF muscles, INSULIN resistance, CHILDHOOD obesity, FREE fatty acids, OBESITY, METABOLISM
Abstract

Objective: This study aimed to phenotype and compare adipose, hepatic, and muscle insulin sensitivity (IS) in a diet- and physical activity-controlled cohort of normoglycemic youth with obesity with that of participants without obesity (controls) to distinguish early metabolic abnormalities in pediatric obesity.Methods: Thirty-eight participants (17 in the control group [BMI < 85th percentile] and 21 youth with obesity [BMI ≥ 95th percentile]; age: 12-21 years; 76% female; Tanner stage 4-5; sedentary) were enrolled. Tissue-specific IS was measured using a four-phase hyperinsulinemic-euglycemic clamp with glucose and glycerol isotope tracers to assess suppression of endogenous glucose release and lipolysis by insulin. Intramyocellular lipid content was assessed by 1 H-magnetic resonance spectroscopy, and hepatic fat fraction (HFF) and visceral fat were assessed by magnetic resonance imaging. Calf-muscle mitochondrial activity was measured with exercise-stimulated 31 P-magnetic resonance spectroscopy.Results: Youth with obesity had higher HFF (P < 0.001), visceral fat (P = 0.024), and intramyocellular lipid content (P = 0.017) and lower muscle (glucose clearance rate [P < 0.001]), adipose (P < 0.0001), and hepatic IS (P < 0.003). Mitochondria postexercise response was not different. In participants with obesity, muscle IS inversely correlated with HFF (r = 0.700, P = 0.002) and suppressed free fatty acid concentrations (r = -0.65, P = 0.003).Conclusions: Inactive normoglycemic youth with obesity had decreased muscle, adipose, and hepatic IS. Free fatty acids and liver fat were inversely associated with muscle IS, which argues for lipid-targeted interventions. [ABSTRACT FROM AUTHOR]

Published
2019
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80. Single‐leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes.

Author

Scalzo, Rebecca L., Schauer, Irene E., Rafferty, Deirdre, Knaub, Leslie A., Kvaratskhelia, Nina, Johnson, Taro Kaelix, Pott, Gregory B., Abushamat, Layla A., Whipple, Mary O., Huebschmann, Amy G., Cree‐Green, Melanie, Reusch, Jane E. B., and Regensteiner, Judith G.

Subjects
SKELETAL muscle, EXERCISE therapy, TYPE 2 diabetes, BLOOD flow, CARDIOPULMONARY fitness
Abstract

Key points: People with type 2 diabetes (T2D) have impaired skeletal muscle oxidative flux due to limited oxygen delivery.In the current study, this impairment in oxidative flux in people with T2D was abrogated with a single‐leg exercise training protocol.Additionally, single‐leg exercise training increased skeletal muscle CD31 content, calf blood flow and state 4 mitochondrial respiration in all participants. Cardiorespiratory fitness is impaired in type 2 diabetes (T2D), conferring significant cardiovascular risk in this population; interventions are needed. Previously, we reported that a T2D‐associated decrement in skeletal muscle oxidative flux is ameliorated with acute use of supplemental oxygen, suggesting that skeletal muscle oxygenation is rate‐limiting to in vivo mitochondrial oxidative flux during exercise in T2D. We hypothesized that single‐leg exercise training (SLET) would improve the T2D‐specific impairment in in vivo mitochondrial oxidative flux during exercise. Adults with (n = 19) and without T2D (n = 22) with similar body mass indexes and levels of physical activity participated in two weeks of SLET. Following SLET, in vivo oxidative flux measured by 31P‐MRS increased in participants with T2D, but not people without T2D, measured by the increase in initial phosphocreatine synthesis (P = 0.0455 for the group × exercise interaction) and maximum rate of oxidative ATP synthesis (P = 0.0286 for the interaction). Additionally, oxidative phosphorylation increased in all participants with SLET (P = 0.0209). After SLET, there was no effect of supplemental oxygen on any of the in vivo oxidative flux measurements in either group (P > 0.02), consistent with resolution of the T2D‐associated oxygen limitation previously observed at baseline in subjects with T2D. State 4 mitochondrial respiration also improved in muscle fibres ex vivo. Skeletal muscle vasculature content and calf blood flow increased in all participants with SLET (P < 0.0040); oxygen extraction in the calf increased only in T2D (P = 0.0461). SLET resolves the T2D‐associated impairment of skeletal muscle in vivo mitochondrial oxidative flux potentially through improved effective blood flow/oxygen delivery. [ABSTRACT FROM AUTHOR]

Published
2022
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81. Targeting the cardiovascular system with sitagliptin improves diastolic cardiac function but does not improve cardiorespiratory fitness in adults with type 2 diabetes

Author

Scalzo, Rebecca L., Rafferty, Deirdre, Schauer, Irene, Huebschmann, Amy G., Cree-Green, Melanie, Reusch, Jane E.B., and Regensteiner, Judith G.

Subjects
Blood Glucose, Glycated Hemoglobin, Male, endocrine system, Dipeptidyl-Peptidase IV Inhibitors, Sitagliptin Phosphate, Middle Aged, Article, Oxidative Phosphorylation, Placebos, Oxygen Consumption, Sulfonylurea Compounds, Cardiorespiratory Fitness, Diabetes Mellitus, Type 2, Double-Blind Method, Diastole, Humans, Hypoglycemic Agents, Female, Muscle, Skeletal, Aged
Abstract

People with type 2 diabetes mellitus (T2D) have preclinical cardiac and vascular dysfunction associated with low cardiorespiratory fitness (CRF). This is especially concerning because CRF is a powerful predictor of cardiovascular mortality, a primary issue in T2D management. Glucagon-like pepetide-1 (GLP-1) augments cardiovascular function and our previous data in rodents demonstrate that potentiating the GLP-1 signal with a dipeptidyl peptidase-4 (DPP4) inhibitor augments CRF. Lacking are pharmacological treatments which can target T2D-specific physiological barriers to exercise to potentially permit adaptations necessary to improve CRF and thereby health outcomes in people with T2D. We therefore hypothesized that administration of a DPP4-inhibitor (sitagliptin) would improve CRF in adults with T2D.Thirty-eight participants (64 ± 1 years; mean ± SE) with T2D were randomized in a double-blinded study to receive 100 mg/day sitagliptin, 2 mg/day glimepiride, or placebo for 3 months after baseline measurements. Fasting glucose decreased with both glimepiride and sitagliptin compared with placebo (P = 0.002). CRF did not change in any group (Placebo: Pre: 15.4 ± 0.9 vs. Post: 16.1 ± 1.1 ml/kg/min vs. Glimepiride: 18.5 ± 1.0 vs. 17.7 ± 1.2 ml/kg/min vs. Sitagliptin: 19.1 ± 1.2 vs. 18.3 ± 1.1 ml/kg/min; P = 0.3). Sitagliptin improved measures of cardiac diastolic function, however, measures of vascular function did not change with any treatment.Three months of sitagliptin improved diastolic cardiac function, however, CRF did not change. These data suggest that targeting the physiological contributors to CRF with sitagliptin alone is not an adequate strategy to improve CRF in people with T2D.www.clinicaltrials.gov NCT01951339.

Published
2019

89. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study

Author

Wiromrat, Pattara, primary, Bjornstad, Petter, additional, Roncal, Carlos, additional, Cree-Green, Melanie, additional, Baumgartner, Amy, additional, Coe, Gregory, additional, Reyes, Yesenia Garcia, additional, Schäfer, Michal, additional, Truong, Uyen, additional, Pyle, Laura, additional, Johnson, Richard J., additional, and Nadeau, Kristen J., additional

Published
2019
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90. 1347-P: Improvement in Peripheral Insulin Sensitivity (IS) with Metformin (MET) in Adolescents with Type 1 Diabetes (T1D) Is Not Mediated by Muscle Mitochondrial Change

Author

TOMMERDAHL, KALIE L., primary, CREE-GREEN, MELANIE, additional, BJORNSTAD, PETTER, additional, CARREAU, ANNE-MARIE, additional, REYES, YESENIA GARCIA, additional, BAUMGARTNER, AMY D., additional, BROWN, MARK S., additional, NEWCOMER, BRADLEY, additional, REUSCH, JANE E.B., additional, and NADEAU, KRISTEN J., additional

Published
2019
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91. 124-OR: Comparison of OGTT Model-Derived Measures of ß-Cell Function between Youth and Adults

Author

UTZSCHNEIDER, KRISTINA, primary, MARI, ANDREA, additional, TRIPPUTI, MARK, additional, MATHER, KIEREN J., additional, NADEAU, KRISTEN J., additional, EDELSTEIN, SHARON, additional, HANNON, TAMARA S., additional, ARSLANIAN, SILVA A., additional, CREE-GREEN, MELANIE, additional, BUCHANAN, THOMAS A., additional, CAPRIO, SONIA, additional, KAHN, STEVEN E., additional, and CONSORTIUM, RISE, additional

Published
2019
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93. Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes

Author

Cree-Green, Melanie, primary, Bergman, Bryan C, additional, Cengiz, Eda, additional, Fox, Larry A, additional, Hannon, Tamara S, additional, Miller, Kellee, additional, Nathan, Brandon, additional, Pyle, Laura, additional, Kahn, Darcy, additional, Tansey, Michael, additional, Tichy, Eileen, additional, Tsalikian, Eva, additional, Libman, Ingrid, additional, and Nadeau, Kristen J, additional

Published
2019
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98. Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome

Author

Simon, Stacey L, primary, McWhirter, Laura, additional, Diniz Behn, Cecilia, additional, Bubar, Kate M, additional, Kaar, Jill L, additional, Pyle, Laura, additional, Rahat, Haseeb, additional, Garcia-Reyes, Yesenia, additional, Carreau, Anne-Marie, additional, Wright, Kenneth P, additional, Nadeau, Kristen J, additional, and Cree-Green, Melanie, additional

Published
2019
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100. Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women

Author

Pereira-Eshraghi, Camila F., primary, Chiuzan, Codruta, additional, Zhang, Yuan, additional, Tao, Rachel H., additional, McCann, Matthew, additional, Neugut, Y. Dana, additional, Printz, Alison, additional, Fennoy, Ilene, additional, Cree-Green, Melanie, additional, Oberfield, Sharon E., additional, and Sopher, Aviva B., additional

Published
2019
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