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Several studies have now reported associations between gestational diabetes mellitus (GDM) and low free thyroxine (fT4) during the second and third trimesters, but not in the first trimester. The present study further examines relationships between low fT4, maternal weight, and GDM among women in the FaSTER (First and Second Trimester Evaluation of Risk) trial, in an effort to determine the extent to which thyroid hormones might contribute to causality. The FaSTER cohort includes 9351 singleton, euthyroid women; 272 of these women were subsequently classified as having GDM. Thyrotropin (TSH), fT4, and thyroid antibodies were measured at 11–14 weeks’ gestation (first trimester) and 15–18.9 weeks’ gestation (second trimester). An earlier report of this cohort documented an inverse relationship between fT4 in the second trimester and maternal weight. In the current analysis, women with GDM were significantly older (32 vs. 28 years) and weighed more (75 vs. 64.5 kg). Maternal weight and age (but not TSH) were significantly associated univariately with fT4 (dependent variable), in the order listed. Second trimester fT4 odds ratios (OR) for GDM were 2.06 [95% CI 1.37–3.09] (unadjusted); and 1.89 [95% CI 1.26–2.84] (adjusted). First trimester odds ratios were not significant: OR 1.45 [95%CI 0.97–2.16] (unadjusted) and 1.11 [95% CI 0.74–1.62] (adjusted). The second trimester fT4/GDM relationship thus appeared to strengthen as gestation progressed. In FaSTER, high maternal weight was associated with both low fT4 and a higher GDM rate in the second trimester. Peripheral deiodinase activity is known to increase with high caloric intake (represented by high weight). We speculate that weight-related low fT4 (the metabolically inactive prohormone) is a marker for deiodinase activity, serving as a substrate for conversion of fT4 to free triiodothyronine (fT3), the active hormone responsible for glucose-related metabolic activity. [ABSTRACT FROM AUTHOR]

Comments on several articles about internal medicine. Treatment approach for Zollinger-Ellison syndrome after gastrinoma resection; Levels of lipoproteins in nephrotic syndrome; Role of urea excretion rate in the development of hyperkalemia.

This article examines the serious effects of cannabis toxicity in children, particularly in a pediatric intensive care unit (PICU). The study focuses on admissions for cannabis intoxication at a children's hospital in Maine and reveals that half of the cases required critical care in the PICU. Accidental ingestion of edible cannabis products intended for recreational use was the primary cause of these cases. The study emphasizes the necessity of child-resistant packaging and public awareness campaigns to prevent severe cannabis toxicity in children. Additionally, the article presents a case study of a patient who experienced diffuse alveolar hemorrhage, a condition where blood leaks into the air sacs of the lungs, due to cannabis use. The authors stress the importance of ruling out other potential causes before diagnosing this condition, such as infections or autoimmune diseases. While the study suggests a potential link between cannabis use and lung bleeding, further research is required to fully comprehend this relationship. [Extracted from the article]

Several letters to the editor are presented in response to the article "Prevalence and Risk of Progression of Light-Chain Monoclonal Gammopathy of Undetermined Significance: A Retrospective Population-Based Cohort Study," by Angela Dispenzieri and colleagues in the May 15, 2010 issue, along with a response from the authors of the article.

Background: Anti-extractable nuclear antigen antibodies (anti-ENA) have diagnostic significance in systemic rheumatic disease (SRD)., Methods: Anti-ENA were tested in 1685/30,196 sera that were submitted sequentially for antinuclear antibody (ANA) testing. Frequency was stratified by ANA titer and pattern, by referral source, by submitted diagnosis and by patient age and sex., Results: Anti-ENA frequency increased with ANA titer (7.3% at < 32%-43.3% at ≥ 1024). Anti-histone (11.6%) and anti-SSA/SSB (13.9%) were the most frequent finding with a homo\xadgeneous pattern; anti-SSA/SSB (39.7%) and anti-RNP/anti-Sm (37.7%) were the most frequent finding with a speckled pattern. Sera with speckled, multiple and homogenous ANA patterns accounted for 92.6% of positive anti-ENA findings. At ANA titer ≥ 256, 29.2% of these sera were tested for anti-ENA, of which 41.2% were positive; frequency was higher with an accompanying diagnosis of SRD (53.5% vs. 36.5%, p < 0.004 by χ2-test) but not with referral by rheumatologists (43.5% vs. 35.9%) and did not differ by patient age or sex., Conclusions: Reflexive anti-ENA testing may be helpful among sera with ANA titer ≥ 256 and homogeneous, speckled or multiple patterns, irrespective of referral source or accompanying diagnosis. Further work is needed to evaluate the clinical impact of this protocol.

The appropriate clinical use of serum iron and transferrin saturation (TSAT) requires satisfactory reference intervals from birth to old age, and for males and females. This study identified 54 publications from 1974 to 2001 that met the criteria used in three prior meta-analyses, and these were analyzed statistically. A summary of our review is presented along with our reference population data on these measurements. This analysis places previous publications in perspective and suggests possible reasons for the observed differences. Previous studies of the individual analytes, serum iron, transferrin, and TSAT values agree with the reference ranges presented in this study, although the entire experience over time and between sexes has not been available before. Our 95% reference ranges are somewhat broader than those of the smaller studies, but they agree well with those of the larger ones., (Copyright 2002 Wiley-Liss, Inc.)