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A novel 4-thiazolidinone derivative Les-6490 (pyrazol-4-thiazolidinone hybrid) was designed, synthesized, and characterized by spectral data. The compound was screened for its antimicrobial activity against some pathogenic bacteria and fungi and showed activity against Staphylococcus and Saccharomyces cerevisiae (the Minimum Inhibitory Concentration (MIC) 820 μM). The compound was studied in the rat adjuvant arthritis model (Freund's Adjuvant) in vivo. Parietal and fecal microbial composition using 16S rRNA metagenome sequences was checked. We employed a range of analytical techniques, including Taxonomic Profiling (Taxa Analysis), Diversity Metrics (Alpha and Beta Diversity Analysis), Multivariate Statistical Methods (Principal Coordinates Analysis, Principal Component Analysis, Non-Metric Multidimensional Scaling), Clustering Analysis (Unweighted Pair-group Method with Arithmetic Mean), and Comparative Statistical Approaches (Community Differences Analysis, Between Group Variation Analysis, Metastat Analysis). The compound significantly impacted an increasing level of anti-inflammatory microorganisms ( Blautia , Faecalibacterium prausnitzii , Succivibrionaceae , and Coriobacteriales ) relative recovery of fecal microbiota composition. Anti-Treponemal activity in vivo was also noted. The tested compound Les-6490 has potential prebiotic activity with an indirect anti-inflammatory effect.

Britain has a reputation for having a stock market-oriented corporate economy and there is an extensive literature maintaining that laws affording substantial protection to outside investors are needed for a thriving stock market. Historically, however, UK equity markets have not always flourished and, when they have, law's contribution has been open to question. This article considers the uneasy match between law and Britain's stock market development from when shares first began to trade publicly through to the present day, offering in so doing insights into the relationship between law and equity markets and current reforms intended to revive a flagging UK stock exchange., (© The Author(s) 2023. Published by Oxford University Press.)

Rising unemployment is one of the consequences of the COVID-19 pandemic in many countries. This, in turn, has forced policymakers to respond immediately with policy tools to minimize unemployment. The purpose of our study is to contribute to empirical knowledge by looking at activities of 40 local government units to counteract unemployment in the cross-border region on the Polish side. In doing this, our study contributes to the efforts to manage unemployment in times of COVID-19 and other crisis situations. The results show that most of the rural and rural-urban communes did not undertake diagnostic activities that would allow one to identify the economic sectors most affected by changes related to the COVID-19 pandemic, e.g., reduction in the number of employees, suspension, or liquidation of activities. According to LGUs surveyed, companies operating in rural-urban communes applied much more frequently for support for job protection in connection with the COVID-19 pandemic than companies located in rural communes. The COVID-19 pandemic demonstrated the crucial role of LGUs in overcoming its impacts. The empirical results of this study (in-depth interviews) indicate that policy makers should pay more attention to consolidating or strengthening the role of LGUs in national disaster management and provide them with the competencies and resources necessary to deal with emergencies (in particular, they concern strengthening cooperation and coordination with other levels of government, effective communication and sharing of good practices also in cross-border areas). It would strengthen decision support systems (DSS) in the regions., (© 2022 The Author(s). Published by Elsevier B.V.)

Libra is the first private cryptocurrency with the potential to change the landscape of global payment and monetary systems. Due to the scale and reach provided by its affiliation with Facebook, the question is not whether, but how, to regulate it. This article introduces the Libra project and analyses the potential responses open to regulators worldwide. We conclude that perhaps the greatest impact will come not from Libra itself, but rather from reactions to it, particularly by other BigTechs, incumbent financial institutions and governments around the world., (© The Author(s) 2020. Published by Oxford University Press.)

The Musée Dupuytren was a Parisian pathology museum established in 1835. This museum hosted 3 skulls with severe craniofacial lesions initially tagged as aggressive forms of tinea capitis. The aim of this study was to investigate these specimens and discuss the initial diagnosis. Historical investigations were conducted based on the biographic data from the tags of the 3 skulls and entries on the catalog of the museum. Age was determined using dentition and the patency of cranial base synchondroses. The computed tomography scans were performed using standard medical devices. The 3 skulls were from the late 18th to early 19th century. Skull № 1 was a 5-year-old child and presented with microcephaly and extensive vault osteolysis compatible with an aggressive benign lesion, a malignant tumor, or a chronic infection. Skull № 2 was a 12- to 18-year-old teenager and presented with symmetrical porotic hyperostosis compatible with undernutrition and various hematologic conditions causing prolonged anemia, but also with chronic inflammation and/or infection. Skull № 3 was also from a 12- to 18-year-old teenager and presented with focal temporal osteolysis compatible with an aggressive benign or a low-grade malignant temporal soft-tissue lesion or with chronic infection. These skulls contribute to the understanding of the concept of tinea in the 19th century. They are furthermore windows on the sanitary and social conditions in Paris in the years following the French revolution and during the Napoleonian wars.