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Copyright of GeoHumanities is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aims: Extramammary Paget disease (EMPD) is an epithelial neoplasm that can occur at many sites, including the vulva and scrotum. EMPD is characterised by the presence of neoplastic cells, in single cells and clusters, that infiltrate all layers of non‐neoplastic squamous epithelium. The differential diagnosis for EMPD includes melanoma in situ and secondary involvement of tumours from other sites, such as urothelial or cervical; pagetoid spread of tumor cells can also been seen at other sites, such as anorectal mucosa. The most frequently utilised biomarkers for confirming the diagnosis of EMPD include CK7 and GATA3; however, these biomarkers lack specificity. The purpose of this study was to evaluate TRPS1, a newly described breast biomarker, in pagetoid neoplasms of the vulva, scrotum and anorectum. Methods and results: Fifteen cases of primary EMPD of the vulva (two with associated invasive carcinoma) and four primary EMPD of the scrotum showed strong nuclear immunoreactivity for TRPS1. In contrast, five cases of vulvar melanoma in situ, one case of urothelial carcinoma with secondary pagetoid spread into the vulva and two anorectal adenocarcinomas with pagetoid spread into anal skin (one with associated invasive carcinoma) were negative for TRPS1. Additionally, weak nuclear TRPS1 staining was observed in non‐neoplastic tissues (e.g. keratinocytes), but always with less intensity when compared to tumour cells. Conclusions: These results demonstrate that TRPS1 is a sensitive and specific biomarker for EMPD, and may be especially useful for excluding secondary involvement of the vulva by urothelial and anorectal carcinomas. [ABSTRACT FROM AUTHOR]

Describes AcqWeb, a Web site that has pertinent information for library acquisitions. Topics include the partnership with ACQNET, the electronic news group for acquisitions; AcqWeb's structure; editorial policy; the International Directory of E-mail Addresses of Publishers, Vendors and Related Professional Associations; and future possibilities. (LRW)

Abstract This chapter of The No Shelf Required Guide to E-book Purchasing examines the challenges that of purchasing e-books for academic libraries from online vendors and suggests solutions and workaround [...]

This article describes an academic library's experience developing and sustaining a literary festival as a collaborative effort. The Eastern North Carolina Literary Homecoming (ENCLH) is a year-long program of events that celebrates the culture and literature of North Carolina. With activities in 6 counties located in the mid-coastal region of North Carolina, the program provides a rich opportunity for people of this area to learn about and meet North Carolina artists. In the past the program was restricted to artists with connections to Eastern North Carolina, but the program is expanding its coverage in 2011. The program theme for 2011 will focus on the impact of environmental literature on social change. This event has been a successful collaboration between a number of cultural institutions, with Joyner Library at East Carolina University serving as the lead. Federal, state and private grant funding has been secured for several years. Key players in the mix include the editor and staff of the North Carolina Literary Review, along with staff from the local public library and members of the ECU faculty as well as librarians from other regional schools. Keywords: Literary Collaboration; North Carolina Literary Review; East Carolina University; Literary Festivals, Introduction East Carolina University is part of the University of North Carolina system of 17 schools and universities. ECU is the third-largest university in the system, with over 27,000 students [...]

A research project was undertaken by a university library system to develop a sustainable user experience strategy. A task force was convened to conduct a pilot project with members from both libraries in the system to assess staffing responsibilities, guidelines, processes, and data-gathering procedures. The team tested an electronic resources list common to both libraries. In describing the methods employed by the task force in their research, this article outlines the benefits and drawbacks of staffing configurations to initiate user experience practices in an academic library setting. [ABSTRACT FROM PUBLISHER]

An experience of heightened perception by characters in literary or dramatic works is often signaled by the use of the word 'methought.' Readers and audiences are alerted that the experience being conveyed altered the character's consciousness or viewpoint, which may impact future behavior and/or action. Since the word is considered archaic, however, it is not used in modern works.

Objectives: Comparative assessments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) molecular assays that have been operationalized through the US Food and Drug Administration's Emergency Use Authorization process are warranted to assess real-world performance. Characteristics such as sensitivity, specificity, and false-negative rate are important to inform clinical use.Methods: We compared five SARS-CoV-2 assays using nasopharyngeal and nasal swab specimens submitted in transport media; we enriched this cohort for positive specimens, since we were particularly interested in the sensitivity and false-negative rate. Performance of each test was compared with a composite standard.Results: The sensitivities and false-negative rates of the 239 specimens that met inclusion criteria were, respectively, as follows: Centers for Disease Control and Prevention 2019 nCoV Real-Time RT-PCR Diagnostic Panel, 100% and 0%; TIB MOLBIOL/Roche z 480 Assay, 96.5% and 3.5%; Xpert Xpress SARS-CoV-2 (Cepheid), 97.6% and 2.4%; Simplexa COVID-19 Direct Kit (DiaSorin), 88.1% and 11.9%; and ID Now COVID-19 (Abbott), 83.3% and 16.7%.Conclusions: The assays that included a nucleic acid extraction followed by reverse transcription polymerase chain reaction were more sensitive than assays that lacked a full extraction. Most false negatives were seen in patients with low viral loads, as extrapolated from crossing threshold values. [ABSTRACT FROM AUTHOR]