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52. Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus

Author

Lande, R., Palazzo, R., Gestermann, N., Jandus, C., Falchi, M., Spadaro, F., Riccieri, V., James, E. A., Butera, A., Boirivant, M., Feldmeyer, L., Surbeck, I., Di Lucca, J., Stuber, F., Spinelli, F. R., Botti, E., Marinari, B., Bianchi, L., Pica, R., Cerbelli, B., Giannakakis, K., Auteri, S. E., Daniels, I., Durrant, L. G., Horstman, S., Costanzo, A., Romero, P., Alessandri, C., Conti, F., Valesini, G., Gilliet, M., Chizzolini, C., and Frasca, L.

Published
2020
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57. Glucocorticoid tapering and associated outcome in patients with newly diagnosed systemic lupus erythematosus: the real-world GULP prospective observational study

Author

Floris, A, Chessa, E, Sebastiani, G, Prevete, I, Iannone, F, Coladonato, L, Govoni, M, Bortoluzzi, A, Mosca, M, Tani, C, Doria, A, Iaccarino, L, Franceschini, F, Fredi, M, Conti, F, Spinelli, F, Bellisai, F, D'Alessandro, R, Zanetti, A, Carrara, G, Scire, C, Cauli, A, Piga, M, Floris A., Chessa E., Sebastiani G. D., Prevete I., Iannone F., Coladonato L., Govoni M., Bortoluzzi A., Mosca M., Tani C., Doria A., Iaccarino L., Franceschini F., Fredi M., Conti F., Spinelli F. R., Bellisai F., D'Alessandro R., Zanetti A., Carrara G., Scire C. A., Cauli A., Piga M., Floris, A, Chessa, E, Sebastiani, G, Prevete, I, Iannone, F, Coladonato, L, Govoni, M, Bortoluzzi, A, Mosca, M, Tani, C, Doria, A, Iaccarino, L, Franceschini, F, Fredi, M, Conti, F, Spinelli, F, Bellisai, F, D'Alessandro, R, Zanetti, A, Carrara, G, Scire, C, Cauli, A, Piga, M, Floris A., Chessa E., Sebastiani G. D., Prevete I., Iannone F., Coladonato L., Govoni M., Bortoluzzi A., Mosca M., Tani C., Doria A., Iaccarino L., Franceschini F., Fredi M., Conti F., Spinelli F. R., Bellisai F., D'Alessandro R., Zanetti A., Carrara G., Scire C. A., Cauli A., and Piga M.

Abstract

Objective A subanalysis of the multicentre Early Lupus inception cohort was performed to investigate the real-world Glucocorticoids (GCs) Use in newly diagnosed systemic lupus erythematosus (SLE) Patients (GULP). Methods Patients starting prednisone (PDN) ≥5 mg/day and concomitant hydroxychloroquine or immunosuppressant within 12 months of SLE classification were enrolled. Core set variables were recorded at baseline and every 6 months, including changes in PDN dose, European Consensus Lupus Activity Measurement (ECLAM) and Systemic Lupus International Collaborating Clinics damage index. Regression models analysed predictors of tapering PDN<5 mg/day at any time and outcomes associated with different patterns of GCs tapering. Results The GULP study included 127 patients with SLE; 73 (57.5%) tapered and maintained PDN <5 mg/ day, and 17 (13.4%) discontinued PDN within a 2-year follow-up. Renal involvement (HR: 0.41; p=0.009) and lower C3 serum levels (HR: 1.04; p=0.025) predicted a lack of PDN tapering below 5 mg/day. High ECLAM scores were associated with a greater probability of increasing PDN dose (OR: 1.6; p=0.004), independently of daily intake. Disease relapse rate did not statistically differ (p=0.706) between patients tapering PDN <5 mg/day (42/99, 42.4%) and those tapering PDN without dropping below 5 mg/day (13/28, 46.4%). Every month on PDN <5 mg/day associated with lower damage accrual (IRR: 0.96; p=0.007), whereas never tapering PDN <5 mg/day associated with a higher risk of developing GC-related damage (OR 5.9; p=0.014). Conclusion Tapering PDN <5 mg/day was achieved and maintained in half of newly diagnosed patients with SLE and may represent a good balance between the need to prevent damage accrual and the risk of disease relapse.

Published
2022

58. Notulae to the Italian alien vascular flora: 14

Author

Galasso, G, Domina, G, Andreatta, S, Argenti, C, Astuti, G, Bacaro, G, Bacchetta, G, Bagella, S, Banfi, E, Barberis, D, Bartolucci, F, Bernardo, L, Bonari, G, Brundu, G, Buccomino, G, Calvia, G, Cancellieri, L, Capuano, A, Celesti-Grapow, L, Conti, F, Cuena-Lombraña, A, D’Amico, F, De Fine, G, de Simone, L, Guacchio, E, Emili, F, Fanfarillo, E, Fascetti, S, Fiaschi, T, Fois, M, Fortini, P, Gentili, R, Giardini, M, Hussain, A, Iamonico, D, Laface, V, Lallai, A, Lazzaro, L, Lecis, A, Ligato, E, Loi, G, Lonati, M, Lozano, V, Maccherini, S, Mainetti, A, Mascia, F, Mei, G, Menini, F, Merli, M, Montesano, A, Mugnai, M, Musarella, C, Nota, G, Olivieri, N, Passalacqua, N, Pinzani, L, Pisano, A, Pittarello, M, Podda, L, Posillipo, G, Potenza, G, Probo, M, Prosser, F, Quaglini, L, Enri, S, Rivieccio, G, Roma-Marzio, F, Rosati, L, Selvaggi, A, Soldano, A, Stinca, A, Tasinazzo, S, Tassone, S, Terzi, M, Vallariello, R, Vangelisti, R, Verloove, F, Lastrucci, L, Galasso G., Domina G., Andreatta S., Argenti C., Astuti G., Bacaro G., Bacchetta G., Bagella S., Banfi E., Barberis D., Bartolucci F., Bernardo L., Bonari G., Brundu G., Buccomino G., Calvia G., Cancellieri L., Capuano A., Celesti-Grapow L., Conti F., Cuena-Lombraña A., D’Amico F. S., De Fine G., de Simone L., Guacchio E. D., Emili F., Fanfarillo E., Fascetti S., Fiaschi T., Fois M., Fortini P., Gentili R., Giardini M., Hussain A. N., Iamonico D., Laface V. L. A., Lallai A., Lazzaro L., Lecis A. P., Ligato E., Loi G., Lonati M., Lozano V., Maccherini S., Mainetti A., Mascia F., Mei G., Menini F., Merli M., Montesano A., Mugnai M., Musarella C. M., Nota G., Olivieri N., Passalacqua N. G., Pinzani L., Pisano A., Pittarello M., Podda L., Posillipo G., Potenza G., Probo M., Prosser F., Quaglini L. A., Enri S. R., Rivieccio G., Roma-Marzio F., Rosati L., Selvaggi A., Soldano A., Stinca A., Tasinazzo S., Tassone S., Terzi M., Vallariello R., Vangelisti R., Verloove F., Lastrucci L., Galasso, G, Domina, G, Andreatta, S, Argenti, C, Astuti, G, Bacaro, G, Bacchetta, G, Bagella, S, Banfi, E, Barberis, D, Bartolucci, F, Bernardo, L, Bonari, G, Brundu, G, Buccomino, G, Calvia, G, Cancellieri, L, Capuano, A, Celesti-Grapow, L, Conti, F, Cuena-Lombraña, A, D’Amico, F, De Fine, G, de Simone, L, Guacchio, E, Emili, F, Fanfarillo, E, Fascetti, S, Fiaschi, T, Fois, M, Fortini, P, Gentili, R, Giardini, M, Hussain, A, Iamonico, D, Laface, V, Lallai, A, Lazzaro, L, Lecis, A, Ligato, E, Loi, G, Lonati, M, Lozano, V, Maccherini, S, Mainetti, A, Mascia, F, Mei, G, Menini, F, Merli, M, Montesano, A, Mugnai, M, Musarella, C, Nota, G, Olivieri, N, Passalacqua, N, Pinzani, L, Pisano, A, Pittarello, M, Podda, L, Posillipo, G, Potenza, G, Probo, M, Prosser, F, Quaglini, L, Enri, S, Rivieccio, G, Roma-Marzio, F, Rosati, L, Selvaggi, A, Soldano, A, Stinca, A, Tasinazzo, S, Tassone, S, Terzi, M, Vallariello, R, Vangelisti, R, Verloove, F, Lastrucci, L, Galasso G., Domina G., Andreatta S., Argenti C., Astuti G., Bacaro G., Bacchetta G., Bagella S., Banfi E., Barberis D., Bartolucci F., Bernardo L., Bonari G., Brundu G., Buccomino G., Calvia G., Cancellieri L., Capuano A., Celesti-Grapow L., Conti F., Cuena-Lombraña A., D’Amico F. S., De Fine G., de Simone L., Guacchio E. D., Emili F., Fanfarillo E., Fascetti S., Fiaschi T., Fois M., Fortini P., Gentili R., Giardini M., Hussain A. N., Iamonico D., Laface V. L. A., Lallai A., Lazzaro L., Lecis A. P., Ligato E., Loi G., Lonati M., Lozano V., Maccherini S., Mainetti A., Mascia F., Mei G., Menini F., Merli M., Montesano A., Mugnai M., Musarella C. M., Nota G., Olivieri N., Passalacqua N. G., Pinzani L., Pisano A., Pittarello M., Podda L., Posillipo G., Potenza G., Probo M., Prosser F., Quaglini L. A., Enri S. R., Rivieccio G., Roma-Marzio F., Rosati L., Selvaggi A., Soldano A., Stinca A., Tasinazzo S., Tassone S., Terzi M., Vallariello R., Vangelisti R., Verloove F., and Lastrucci L.

Abstract

In this contribution, new data concerning the distribution of vascular flora alien to Italy are presented. It includes new records, confirmations, and status changes for Italy or for Italian administrative regions. Nomenclatural and distribution updates, published elsewhere, and corrections are provided as Suppl. material 1. © Gabriele Galasso et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published
2022

61. AB0771 FEMALE GENDER AND STEROID TREATMENT AS MAIN INFLUENCING FACTORS IN THE PERCEPTION OF QUALITY OF LIFE IN ANCA-ASSOCIATED VASCULITIS: FINAL RESULTS FROM THE ITALIAN VERSION OF ANCA-ASSOCIATED VASCULITIS PATIENT-REPORTED OUTCOME (AAV-PRO_ITA) QUESTIONNAIRE

Author

Treppo, E., primary, Isola, M., additional, De Martino, M., additional, Padoan, R., additional, Urban, M. L., additional, Monti, S., additional, Sartorelli, S., additional, Giollo, A., additional, Argolini, L. M., additional, Marvisi, C., additional, Gattamelata, A., additional, Regola, F., additional, Ferro, F., additional, Cassone, G., additional, Motta, F., additional, Berti, A., additional, Conticini, E., additional, Guiducci, S., additional, Matucci-Cerinic, M., additional, Lo Gullo, A., additional, Manfredi, A., additional, Frediani, B., additional, Bortolotti, R., additional, Selmi, C., additional, Baldini, C., additional, Franceschini, F., additional, Conti, F., additional, Emmi, G., additional, Caporali, R., additional, Rossini, M., additional, Dagna, L., additional, Montecucco, C., additional, Schiavon, F., additional, Salvarani, C., additional, De Vita, S., additional, and Quartuccio, L., additional

Published
2023
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62. AB1765-HPR APPLICATION OF THE EULAR SYSTEMIC SCLEROSIS IMPACT OF DISEASE (SCLEROID) QUESTIONNAIRE IN AN ITALIAN COHORT OF PATIENTS WITH SYSTEMIC SCLEROSIS: ANALYSIS OF PATIENT-REPORTED OUTCOMES AND THEIR ASSOCIATION WITH MAIN DISEASE FEATURES

Author

Bisconti, I., primary, Reza Beigi, D. M., additional, Pellegrino, G., additional, Cadar, M., additional, DI Ciommo, F. R., additional, Stefanantoni, K., additional, Truglia, S., additional, Conti, F., additional, and Riccieri, V., additional

Published
2023
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65. AB0672 DETECTION OF MACROPHAGE MIGRATION INHIBITORY FACTOR IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS COMPLAINING PAINFUL DISTURBANCES: A SINGLE CENTER STUDY

Author

Pirone, C., primary, Ceccarelli, F., additional, Colasanti, T., additional, Galosi, E., additional, Orefice, V., additional, Garufi, C., additional, Natalucci, F., additional, Olivieri, G., additional, Picciariello, L., additional, Falco, P., additional, Di Pietro, G., additional, Spinelli, F. R., additional, Truglia, S., additional, Alessandri, C., additional, Truini, A., additional, and Conti, F., additional

Published
2023
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70. POS1176 HOSPITALIZATION RATES, FEATURES, AND DISCHARGE DIAGNOSES OF A LARGE NATIONWIDE COHORT OF ANCA-ASSOCIATED VASCULITIS

Author

Berti, A., primary, Ottone, M., additional, Sartorelli, S., additional, Treppo, E., additional, Bettiol, A., additional, Padoan, R., additional, Regola, F., additional, Monti, S., additional, Marvisi, C., additional, Giollo, A., additional, Argolini, L. M., additional, Righini, M., additional, Gattamelata, A., additional, Cassone, G., additional, Sottini, L., additional, Maule, M., additional, Toniati, P., additional, Palermo, B. L., additional, Bello, F., additional, Guella, S., additional, Izzo, R., additional, Muratore, F., additional, Catanoso, M. G., additional, Fassio, A., additional, Cataleta, P., additional, Buscaroli, A., additional, Giorgi Rossi, P., additional, Franceschini, F., additional, Caporali, R., additional, Montecucco, C., additional, Conti, F., additional, Emmi, G., additional, Quartuccio, L., additional, Paolazzi, G., additional, Dagna, L., additional, Schiavon, F., additional, Salvarani, C., additional, and Bortolotti, R., additional

Published
2023
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72. AB0429 EIGHT-MONTH FOLLOW-UP OF THE NON-MEDICAL SWITCH FROM ETANERCEPT BIO-ORIGINATOR TO GP-2015 OR SB4 ETANERCEPT BIOSIMILARS IN PATIENTS WITH CHRONIC INFLAMMATORY ARTHROPATHIES: A MONOCENTRIC OBSERVATIONAL STUDY

Author

Castellani, C., primary, Di Sanzo, L., additional, Bevignani, G., additional, Molteni, E., additional, Sciarra, G., additional, Di Franco, M., additional, Alessandri, C., additional, Riccieri, V., additional, Priori, R., additional, Ceccarelli, F., additional, Spinelli, F. R., additional, Scrivo, R., additional, and Conti, F., additional

Published
2023
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74. POS1075 RETENTION RATE OF BIOLOGIC AND TARGETED SYNTHETIC ANTI-RHEUMATIC DRUGS IN ELDERLY PATIENTS AFFECTED BY RHEUMATOID ARTHRITIS: DATA FROM ITALIAN GISEA REGISTRY

Author

Manfredi, A., primary, Iannone, F., additional, Bugatti, S., additional, Favalli, E. G., additional, Franceschini, F., additional, Atzeni, F., additional, Bazzani, C., additional, Cantatore, F. P., additional, Caporali, R., additional, Cauli, A., additional, Conti, F., additional, Ferraccioli, G., additional, Foti, R., additional, Fusaro, E., additional, Iagnocco, A., additional, Govoni, M., additional, Gremese, E., additional, Lapadula, G., additional, Rai, A., additional, Rossini, M., additional, Semeraro, A., additional, and Sebastiani, M., additional

Published
2023
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77. POS0852 REAL LIFE DATA OF FILGOTINIB IN RHEUMATOID ARTHRITIS PATIENTS: DATA FROM ITALIAN GISEA REGISTRY

Author

Fornaro, M., primary, Caporali, R., additional, Montecucco, C., additional, Cauli, A., additional, Conti, F., additional, Chimenti, M. S., additional, Gorla, R., additional, Atzeni, F., additional, Semeraro, A., additional, Gremese, E., additional, Sebastiani, M., additional, Govoni, M., additional, Cantatore, F. P., additional, Santo, L., additional, Frediani, B., additional, Lapadula, G., additional, Ferraccioli, G., additional, and Iannone, F., additional

Published
2023
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78. AB0590 CROSS-SECTIONAL ASSESSMENT OF THE QUALITY OF LIFE IN SLE PATIENTS: ROLE OF DISEASE ACTIVITY, CHRONIC DAMAGE, FIBROMYALGIA SYNDROME AND MOOD DISORDERS

Author

Natalucci, F., primary, Ceccarelli, F., additional, Massari, C., additional, Pirone, C., additional, Olivieri, G., additional, Orefice, V., additional, Picciariello, L., additional, Ciancarella, C., additional, Garufi, C., additional, Mancuso, S., additional, Truglia, S., additional, Spinelli, F. R., additional, Alessandri, C., additional, and Conti, F., additional

Published
2023
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79. AB0689 LIFESTYLE AND NUTRITIONAL STATUS IN ITALIAN PATIENTS WITH ISOLATED SJӦGREN’S SYNDROME

Author

Izzo, R., primary, Colafrancesco, S., additional, Gattamelata, A., additional, Pinto, A., additional, Donini, L. M., additional, Guggino, G., additional, Grasso, G., additional, Matucci-Cerinic, M., additional, Orlandi, M., additional, De Vita, S., additional, Quartuccio, L., additional, Binutti, M., additional, Conti, F., additional, and Priori, R., additional

Published
2023
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80. AB0175 EVALUATION OF THE STATE OF ACTIVATION OF PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH POLYMYALGIA RHEUMATICA

Author

Castellani, C., primary, Colafrancesco, S., additional, Barbati, C., additional, Truglia, S., additional, Buoncuore, G., additional, Priori, R., additional, Sili Scavalli, A., additional, Molteni, E., additional, Sciarra, G., additional, Di Sanzo, L., additional, Bevignani, G., additional, Conti, F., additional, and Scrivo, R., additional

Published
2023
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81. POS0862 PRESCRIPTION PATTERN OF JAK INHIBITORS OVER 5 YEARS IN ITALY: DATA FROM THE ITALIAN NATIONAL GISEA REGISTRY

Author

Spinelli, F. R., primary, Iannone, F., additional, Favalli, E. G., additional, Gremese, E., additional, Bugatti, S., additional, Garufi, C., additional, Atzeni, F., additional, Cauli, A., additional, Sebastiani, M., additional, Carletto, A., additional, Govoni, M., additional, Semeraro, A., additional, Foti, R., additional, Cantatore, F. P., additional, Bazzani, C., additional, Parisi, S., additional, Chimenti, M. S., additional, Frediani, B., additional, Caporali, R., additional, and Conti, F., additional

Published
2023
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83. POS1249 LUNG ULTRASOUND CHANGES COMPARED WITH AUTOMATED QUANTITATIVE COMPUTED TOMOGRAPHY FOR DETECTING SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE

Author

Reza Beigi, D. M., primary, Pellegrino, G., additional, Landini, N., additional, Mattone, M., additional, Paone, G., additional, Truglia, S., additional, DI Ciommo, F. R., additional, Bisconti, I., additional, Cadar, M., additional, Stefanantoni, K., additional, Panebianco, V., additional, Conti, F., additional, and Riccieri, V., additional

Published
2023
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85. AB0558 ANIFROLUMAB IN REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS: A REAL-LIFE, MULTICENTER STUDY

Author

Trentin, F., primary, Tani, C., additional, Cauli, A., additional, Ceccarelli, F., additional, Ciccia, F., additional, Conti, F., additional, Coladonato, L., additional, Dagna, L., additional, De Marchi, G., additional, Emmi, G., additional, Fasano, S., additional, Gatto, M., additional, Moroni, L., additional, Riccio, F., additional, Piga, M., additional, Zen, M., additional, and Mosca, M., additional

Published
2023
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86. Incidence and risk factors of esophagogastric varices bleeding in cirrhotic patients with advanced hepatocellular carcinoma treated with lenvatinib

Author

Iavarone, M., primary, Alimenti, E., additional, Tada, T., additional, Shimose, S., additional, Suda, G., additional, Yoo, C., additional, Soldà, C., additional, Piscaglia, F., additional, Casadei-Gardini, A., additional, Marra, F., additional, Vivaldi, C., additional, Conti, F., additional, Schirripa, M., additional, Iwamoto, H., additional, Sho, T., additional, Lee, So Heun, additional, Rizzato, M.D., additional, Tonnini, M., additional, Rimini, M., additional, Campani, C., additional, Masi, G., additional, Foschi, F., additional, Bruccoleri, M., additional, Kawaguchi, T., additional, Kumada, T., additional, Hiraoka, A., additional, Atsukawa, M., additional, Fukunishi, S., additional, Ishikawa, T., additional, Tajiri, K., additional, Ochi, H., additional, Yasuda, S., additional, Toyoda, H., additional, Hatanaka, T., additional, Kakizaki, S., additional, Kawata, K., additional, Tada, F., additional, Ohama, H., additional, Itokawa, N., additional, Okubo, T., additional, Arai, T., additional, Imai, M., additional, Naganuma, A., additional, Tosetti, G., additional, and Lampertico, P., additional

Published
2023
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87. Attitudes and practices of dentists treating HIV+ patients in the era of new antiretroviral therapy: A 12-year update

Author

Giuliani, M., Patini, Romeo, Lo Muzio, L., Troiano, G., Caponio, V. C. A., Adamo, D., Conti, F., Gallenzi, Patrizia, Lajolo, Carlo, Patini R. (ORCID:0000-0001-7358-8763), Gallenzi P. (ORCID:0000-0001-9805-4522), Lajolo C. (ORCID:0000-0003-4663-9734), Giuliani, M., Patini, Romeo, Lo Muzio, L., Troiano, G., Caponio, V. C. A., Adamo, D., Conti, F., Gallenzi, Patrizia, Lajolo, Carlo, Patini R. (ORCID:0000-0001-7358-8763), Gallenzi P. (ORCID:0000-0001-9805-4522), and Lajolo C. (ORCID:0000-0003-4663-9734)

Abstract

During the first years of the HIV pandemic, the virus diffusion was responsible for discriminatory behavior from medical and dental care workers towards HIV-infected patients, as described by our research group in 2009. The aim of the current study was to provide an update on the previous data, investigating the presence of discriminatory behaviors, evaluating the level of dentists’ knowledge about the virus and proposing strategies to be implemented to avoid professional exposure and cross-infections. This study was a cross-sectional, online, national survey on dentists, members of the main national dental associations (ANDI and AIO). The questionnaire was divided into four major sections, with the same structure as the questionnaire administered in 2009. The differences between groups were analyzed using the software program IBM SPSS Statistic, version 21.0. A total of 1054 dentists filled out the questionnaire completely. Among them 0.04% revealed a discriminatory attitude towards HIV-infected patients. The univariate analysis showed that discrimination towards HIV + patients was statistically associated with personal experiences and the level of fear associated with treating them (p = 0.001) and with the type of dental treatments performed (p = 0.01). This cross-sectional study revealed the persistence of dentists who still discriminate against HIV + patients, and the percentage of these dentists was only slightly lower than that in the previous survey (4.3% in the present survey vs. 4.5%). The survey also depicted other information worthy of consideration, such as a perceived ability to detect HIV + patients based on their appearance, complaints about not having received adequate training for treating HIV + individuals, and a lack of scientific knowledge about the virus. From the evidence reported by the present survey, it can be argued that universities, professional boards, and training institutions must increase their efforts in spreading correct knowledge a

Published
2023

88. The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma

Author

Lai, Quirino, De Matthaeis, Nicoletta, Finotti, Michele, Galati, Giovanni, Marrone, Giuseppe, Melandro, Fabio, Morisco, Filomena, Nicolini, Daniele, Pravisani, Riccardo, Giannini, Edoardo G, Aglitti, A, Aliberti, C, Baccarani, U, Bhoori, S, Borzio, M, Brancaccio, G, Burra, P, Cabibbo, G, Casadei Gardini, A, Carrai, P, Cillo, U, Conti, F, Cucchetti, A, D'Ambrosio, R, Dell'Unto, C, Di Costanzi, Gg, Di Sandro, S, Foschi, Fg, Fucilli, F, Gambato, M, Gasbarrini, Antonio, Giuliante, Felice, Ghinolfi, D, Grieco, Antonio, Gruttaduria, S, Guarino, M, Kostandini, A, Iavarone, M, Lenci, I, Levi Sandri, Gb, Losito, F, Lupo, Lg, Manzia, Tm, Mazzocato, S, Mescoli, C, Miele, Luca, Muley, M, Persico, M, Plaz Torres, Mc, Pompili, Maurizio, Ponziani, Francesca Romana, Rapaccini, Gian Ludovico, Rendina, M, Renzulli, M, Rossi, Marco, Rreka, E, Russo, Fp, Sacco, R, Sangiovanni, A, Sessa, A, Simonetti, N, Sposito, C, Tortora, R, Trevisani, F, Viganò, L, Viganò, M, Villa, E, Vincenzi, V, Violi, P, Vitale, A, Gasbarrini, A (ORCID:0000-0002-7278-4823), Giuliante, F (ORCID:0000-0001-9517-8220), Grieco, A (ORCID:0000-0002-0544-8993), Miele, L (ORCID:0000-0003-3464-0068), Pompili, M (ORCID:0000-0001-6699-7980), Ponziani, FR (ORCID:0000-0002-5924-6238), Rapaccini, GL (ORCID:0000-0002-6467-857X), Rossi, M (ORCID:0000-0002-4539-5670), Lai, Quirino, De Matthaeis, Nicoletta, Finotti, Michele, Galati, Giovanni, Marrone, Giuseppe, Melandro, Fabio, Morisco, Filomena, Nicolini, Daniele, Pravisani, Riccardo, Giannini, Edoardo G, Aglitti, A, Aliberti, C, Baccarani, U, Bhoori, S, Borzio, M, Brancaccio, G, Burra, P, Cabibbo, G, Casadei Gardini, A, Carrai, P, Cillo, U, Conti, F, Cucchetti, A, D'Ambrosio, R, Dell'Unto, C, Di Costanzi, Gg, Di Sandro, S, Foschi, Fg, Fucilli, F, Gambato, M, Gasbarrini, Antonio, Giuliante, Felice, Ghinolfi, D, Grieco, Antonio, Gruttaduria, S, Guarino, M, Kostandini, A, Iavarone, M, Lenci, I, Levi Sandri, Gb, Losito, F, Lupo, Lg, Manzia, Tm, Mazzocato, S, Mescoli, C, Miele, Luca, Muley, M, Persico, M, Plaz Torres, Mc, Pompili, Maurizio, Ponziani, Francesca Romana, Rapaccini, Gian Ludovico, Rendina, M, Renzulli, M, Rossi, Marco, Rreka, E, Russo, Fp, Sacco, R, Sangiovanni, A, Sessa, A, Simonetti, N, Sposito, C, Tortora, R, Trevisani, F, Viganò, L, Viganò, M, Villa, E, Vincenzi, V, Violi, P, Vitale, A, Gasbarrini, A (ORCID:0000-0002-7278-4823), Giuliante, F (ORCID:0000-0001-9517-8220), Grieco, A (ORCID:0000-0002-0544-8993), Miele, L (ORCID:0000-0003-3464-0068), Pompili, M (ORCID:0000-0001-6699-7980), Ponziani, FR (ORCID:0000-0002-5924-6238), Rapaccini, GL (ORCID:0000-0002-6467-857X), and Rossi, M (ORCID:0000-0002-4539-5670)

Abstract

Aim To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment. Methods A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases. Two HCC clinical settings were explored: (i) incidence, and (ii) death after any HCC treatment. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to compare the pooled data between patients who received or did not receive APT. Results A total of 20 studies were identified, of whom 15 focused on HCC incidence, including 2,685,009 patients, and five on post-treatment death, including 3281 patients. APT was associated with an overall reduced risk of HCC incidence (OR: 0.63; 95%CI = 0.51-0.79; p < 0.001) as well as of post-treatment mortality (OR: 0.54; 95%CI = 0.35-0.83; p = 0.006). Conclusions Current data suggest that APT correlated with higher HCC incidence and poor overall survival following tumour treatment.

Published
2023

89. Metabolic syndrome and body weight in people living with HIV infection: analysis of differences observed in three different cohort studies over a decade

Author

Taramasso L., Bonfanti P., Ricci E., Maggi P., Orofino G., Squillace N., Menzaghi B., Madeddu G., Molteni C., Vichi F., Riguccini E., Saracino A., Santoro C., Guastavigna M., Francisci D., Di Biagio A., De Socio G. V., Sarchi E., Chichino G., Bolla C., Bellacosa C., Angarano G., Calza L., Farinazzo M., Angioni G., Gussio M., Celesia B. M., Falasca K., Mastroianni A., Guadagnino G., Salomoni E., Martinelli C., Dentone C., Bassetti M., Cenderello G., Pellicano G. F., Nunnari G., Valsecchi L., Cordier L., Parisini S., Rizzardini G., Rusconi S., Conti F., Bandera A., Gori A., Motta D., Puoti M., Migliorino G. M., Martini S., Cascio A., Trizzino M., Gulminetti R., Nofri M., Cibelli D., Parruti G., Mameli M. S., Taramasso L., Bonfanti P., Ricci E., Maggi P., Orofino G., Squillace N., Menzaghi B., Madeddu G., Molteni C., Vichi F., Riguccini E., Saracino A., Santoro C., Guastavigna M., Francisci D., Di Biagio A., De Socio G.V., Sarchi E., Chichino G., Bolla C., Bellacosa C., Angarano G., Calza L., Farinazzo M., Angioni G., Gussio M., Celesia B.M., Falasca K., Mastroianni A., Guadagnino G., Salomoni E., Martinelli C., Dentone C., Bassetti M., Cenderello G., Pellicano G.F., Nunnari G., Valsecchi L., Cordier L., Parisini S., Rizzardini G., Rusconi S., Conti F., Bandera A., Gori A., Motta D., Puoti M., Migliorino G.M., Martini S., Cascio A., Trizzino M., Gulminetti R., Nofri M., Cibelli D., Parruti G., Mameli M.S., Taramasso, L, Bonfanti, P, Ricci, E, Maggi, P, Orofino, G, Squillace, N, Menzaghi, B, Madeddu, G, Molteni, C, Vichi, F, Riguccini, E, Saracino, A, Santoro, C, Guastavigna, M, Francisci, D, Di Biagio, A, De Socio, G, Taramasso, Lucia, Bonfanti, Paolo, Ricci, Elena, Maggi, Paolo, Orofino, Giancarlo, Squillace, Nicola, Menzaghi, Barbara, Madeddu, Giordano, Molteni, Chiara, Vichi, Francesca, Riguccini, Erika, Saracino, Annalisa, Santoro, Carmen, Guastavigna, Marta, Francisci, Daniela, Di Biagio, Antonio, and De Socio, Giuseppe Vittorio

Subjects
Adult, Male, dyslipidaemia, antiretroviral therapy, HIV Infections, Overweight, Logistic regression, Body Mass Index, Cohort Studies, Prevalence, medicine, overweight, Humans, Pharmacology (medical), Metabolic Syndrome, business.industry, Health Policy, Incidence (epidemiology), Body Weight, HIV, weight gain, Odds ratio, Middle Aged, medicine.disease, Confidence interval, metabolic syndrome, Cross-Sectional Studies, Infectious Diseases, Metabolic syndrome, medicine.symptom, business, Weight gain, Demography, Cohort study
Abstract

Objectives: The aim of this study was to assess the incidence of being overweight and metabolic syndrome (MS) among people living with HIV (PHIV) in three different cross-sectional studies conducted over three different periods: 2005, 2011 and 2015. Methods: This was a multi-centre, nationwide study. Data were collected in three studies from the CISAI group - SIMOne, HIV-HY and STOPSHIV - and included a total of 3014 PHIV. Logistic regression [odds ratio (OR), 95% confidence interval (CI)] was used to account for age and gender difference among three groups when comparing MS prevalence and being overweight; potential confounders were accounted for by including them in the regression equation. Results: Overall, the mean age was 46.9±10.2years, and men comprised 73.3% of participants. Comparing 2005, 2011 and 2015, MS was present in 34.5%, 33.0% and 29.3% of PHIV, respectively. Adjusted OR for MS was 0.64 (95% CI: 0.52-0.78) in 2011 and 0.56 (95% CI: 0.46-0.69) in 2015 compared with 2005, while BMI (kg/m2 ) increased from 23.6 in 2005, 24.5 in 2011 and 24.5 in 2015, with a concomitant increase of being overweight from 29.4% to 39.5% to 39.6% (p&nbsp

Published
2021

90. Dynamics and energy coupling of gas puff Z-pinches on a fast linear transformer driver.

Author

Conti, F., Narkis, J., Williams, A., Fadeev, V., and Beg, F. N.

Subjects
*KINETIC energy, *GASES, *GAS distribution, *COUPLES, *X-rays
Abstract

Gas puff Z-pinch experiments with annular Ar and Ne gas shells have been conducted on the Compact Experimental System for Z-pinch and Ablation Research (CESZAR) linear transformer driver (LTD) with 500 kA current and 160 ns rise time. Here, we present results from the first systematic gas puff Z-pinch experiments using a fast (≤ 200 ns) LTD as a driver, in which we show that 7% of the stored energy in the capacitors is coupled to plasma kinetic energy as estimated via self-emission and laser schlieren images. 0D and 1D simulations—which do not allow instability growth and thus reach greater maximum average velocities—using initial conditions inferred from experimental implosion trajectories predict coupling in excess of 10% of the stored energy. The Ar and Ne implosions were comparably massed and thus achieved similar maximum kinetic energies, though the Ne pinches were more stable and the x-ray pulses were longer and produced higher yield: 2–5 ns and 0.21–0.52 J (0.15–0.37 J/cm) of Ar K-shell and 12–25 ns and 2.2–3.9 J (1.6–2.6 J/cm) of Ne K-shell, respectively. The difference in stability is most likely attributed to variations in initial conditions such as density distribution and gas breakdown initiation. [ABSTRACT FROM AUTHOR]

Published
2021
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91. Effect of insulator surface conditioning on the pinch dynamics and x-ray production of a Ne-filled dense plasma focus.

Author

Housley, D., Hahn, E. N., Narkis, J., Angus, J. R., Link, A. J., Conti, F., and Beg, F. N.

Subjects
PLASMA focus, DENSE plasmas, PLASMA sheaths, X-rays, PLASMA diagnostics, ELECTRIC breakdown, LASER plasmas
Abstract

The dense plasma focus (DPF) can be an intense source of x rays, wherein the insulator sleeve strongly dictates the electrical breakdown, which subsequently affects the formation of a plasma sheath and a collapse phase. Experiments on a 25 kJ DPF (operated at 4.4 kJ) are carried out to demonstrate the influence of insulator surface morphology on the pinch structure, dynamics, and x-ray yield using a Ne fill. Two borosilicate insulators are directly compared, one with a smooth finish and the other machined with four circumferential grooves traversing the perimeter of the exterior insulator surface. Comparisons are made through same-shot imaging diagnostics of the evolving plasma sheath during breakdown, rundown, and at the pinch in addition to the time-resolved measurements of emitted x rays via filtered photodiodes. The presence of structures on the insulator sleeve reduces x-ray production across all fill pressures by a factor of 2.8 ± 2.4 on average and reduces the highest x ray producing shots by a factor of 5.5 ± 1.8. Observations of sheath asymmetry and inhomogeneity at lift-off are observed and correlated with subsequent observations of off-axis radial collapse. Taken together, this suggests that local variations in the insulator surface decrease the spatial uniformity of the sheath, leading to an azimuthally asymmetric focus, reduced electron densities, and, ultimately, degraded x-ray production. [ABSTRACT FROM AUTHOR]

Published
2021
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96. Analysis of sea surface temperature maps via topological machine learning

Author

Conti F., Papini O., Moroni D., Pieri G., Reggiannini M., and Pascali M. A.

Subjects
Sea surface temperature map, Remote sensing, TDA, Marine mesoscale patterns
Abstract

Computational methods to leverage topological features occurring in signals and images are currently one of the most innovative trends in applied mathematics. In this paper a pipeline of topological machine learning is applied to the challenging task of classifying four specific marine mesoscale patterns from remote sensing data, i.e., Sea Surface Temperature maps of the southwestern region of the Iberian Peninsula. Our preliminary study achieves an accuracy of 56% in the 4-label classification. Such results are encouraging, especially considering that the data are affected by noise and that there are low-quality/missing data. Also, the paper devises directions for future improvements.

Published
2023

97. The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma

Author

Lai, Q., De Matthaeis, N., Finotti, M., Galati, G., Marrone, G., Melandro, F., Morisco, F., Nicolini, D., Pravisani, R., Giannini, E. G., Aglitti, A., Aliberti, C., Baccarani, U., Bhoori, S., Borzio, M., Brancaccio, G., Burra, P., Cabibbo, G., Casadei Gardini, A., Carrai, P., Cillo, U., Conti, F., Cucchetti, A., D'Ambrosio, R., Dell'Unto, C., Di Costanzo, G. G., Di Sandro, S., Foschi, F. G., Fucilli, F., Gambato, M., Gasbarrini, A., Giuliante, F., Ghinolfi, D., Grieco, A., Gruttaduria, S., Guarino, M., Kostandini, A., Iavarone, M., Lenci, I., Levi Sandri, G. B., Losito, F., Lupo, L. G., Manzia, T. M., Mazzocato, S., Mescoli, C., Miele, L., Muley, M., Persico, M., Plaz Torres, M. C., Pompili, M., Ponziani, F. R., Rapaccini, G. L., Rendina, M., Renzulli, M., Rossi, M., Rreka, E., Russo, F. P., Sacco, R., Sangiovanni, A., Sessa, A., Simonetti, N., Sposito, C., Tortora, R., Trevisani, F., Vigano, L., Vigano, M., Villa, E., Vincenzi, V., Violi, P., and Vitale, A.

Subjects
clopidogrel, aspirin, Clinical Biochemistry, incidence, occurrence, survival, General Medicine, Biochemistry, Settore MED/18
Abstract

To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment.A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases. Two HCC clinical settings were explored: (i) incidence, and (ii) death after any HCC treatment. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to compare the pooled data between patients who received or did not receive APT.A total of 20 studies were identified, of whom 15 focused on HCC incidence, including 2,685,009 patients, and five on post-treatment death, including 3281 patients. APT was associated with an overall reduced risk of HCC incidence (OR: 0.63; 95%CI = 0.51-0.79; p 0.001) as well as of post-treatment mortality (OR: 0.54; 95%CI = 0.35-0.83; p = 0.006).Current data suggest that APT correlated with higher HCC incidence and poor overall survival following tumour treatment.

Published
2023

100. Direct comparison of wire, foil, and hybrid X-pinches on a 200 kA, 150 ns current driver.

Author

Collins IV, G. W., Valdivia, M. P., Hansen, S. B., Conti, F., Carlson, L. C., Hammer, D. A., Elshafiey, A., Narkis, J., and Beg, F. N.

Subjects
COPPER wire, WIRE, SOFT X rays, ELECTRON beams
Abstract

Wire X-pinches (WXPs) have been studied comprehensively as fast (∼ 1 ns pulse width), small (∼ 1 μ m) x-ray sources, created by twisting two or more fine wires into an "X" to produce a localized region of extreme magnetic pressure at the cross-point. Recently, two alternatives to the traditional WXP have arisen: the hybrid X-pinch (HXP), composed of two conical electrodes bridged by a thin wire or capillary, and the laser-cut foil X-pinch (LCXP), cut from a thin foil using a laser. We present a comparison of copper wire, hybrid, and laser-cut foil X-pinches on a single experimental platform: UC San Diego's ∼ 200 kA, 150 ns rise time GenASIS driver. All configurations produced 1–2 ns pulse width, ≤ 5 μ m soft x-ray (Cu L-shell, ∼ 1 keV) sources (resolutions diagnostically limited) with comparable fluxes. WXP results varied with linear mass and wire count, but consistently showed separate pinch and electron-beam-driven sources. LCXPs produced the brightest (∼ 1 MW), smallest (≤ 5 μ m) Cu K-shell sources, and spectroscopic data showed both H-like Cu K α lines indicative of source temperatures ≥ 2 keV, and cold K α (∼ 8050 eV) characteristic of electron beam generated sources, which were not separately resolved on other diagnostics (within 1–2 ns and ≤ 200 μ m). HXPs produced minimal K-shell emission and reliably single, bright, and small L-shell sources after modifications to shape the early current pulse through them. Benefits and drawbacks for each configuration are discussed to provide potential X-pinch users with the information required to choose the configuration best suited to their needs. [ABSTRACT FROM AUTHOR]

Published
2021
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