682 results on '"Conde, Lucia"'
Search Results
52. USING MULTI-POLYGENIC RISK SCORE ANALYSES TO PREDICT ANOREXIA NERVOSA CASE STATUS
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Sidari, Morgan, primary, Mitchell, Brittany, additional, Conde, Lucia Colodro, additional, Maguire, Sarah, additional, Kennedy, Martin, additional, Jordan, Jenny, additional, Parker, Richard, additional, Bulik, Cynthia, additional, and Martin, Nick, additional
- Published
- 2022
- Full Text
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53. Breastfeeding and Health
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Colodro-Conde, Lucia, primary
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- 2017
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- View/download PDF
54. Contributors
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Aparicio-García, Marta E., primary, Bottorff, Joan L., additional, Brabete, Andreea C., additional, Chrisler, Joan C., additional, Colodro-Conde, Lucia, additional, Cuéllar-Flores, Isabel, additional, Díaz-Morales, Juan F., additional, Goodall, Karen, additional, Hepworth, Julie, additional, Johnson, Joy L., additional, Kelly, Mary T., additional, Lander, Nedra R., additional, Limiñana-Gras, Rosa M., additional, McVittie, Chris, additional, Nahon, Danielle, additional, Newbigging, Karen, additional, Oliffe, John L., additional, Patró-Hernández, Rosa M., additional, Read, Jennan G., additional, Rieker, Patricia P., additional, Sánchez-López, M. Pilar, additional, Schiebinger, Londa, additional, and Wong, Sabrina T., additional
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- 2017
- Full Text
- View/download PDF
55. Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia
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McMaster, Mary L., Berndt, Sonja I., Zhang, Jianqing, Slager, Susan L., Li, Shengchao Alfred, Vajdic, Claire M., Smedby, Karin E., Yan, Huihuang, Birmann, Brenda M., Brown, Elizabeth E., Smith, Alex, Kleinstern, Geffen, Fansler, Mervin M., Mayr, Christine, Zhu, Bin, Chung, Charles C., Park, Ju-Hyun, Burdette, Laurie, Hicks, Belynda D., Hutchinson, Amy, Teras, Lauren R., Adami, Hans-Olov, Bracci, Paige M., McKay, James, Monnereau, Alain, Link, Brian K., Vermeulen, Roel C. H., Ansell, Stephen M., Maria, Ann, Diver, W. Ryan, Melbye, Mads, Ojesina, Akinyemi I., Kraft, Peter, Boffetta, Paolo, Clavel, Jacqueline, Giovannucci, Edward, Besson, Caroline M., Canzian, Federico, Travis, Ruth C., Vineis, Paolo, Weiderpass, Elisabete, Montalvan, Rebecca, Wang, Zhaoming, Yeager, Meredith, Becker, Nikolaus, Benavente, Yolanda, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Nieters, Alexandra, de Sanjose, Silvia, Staines, Anthony, Conde, Lucia, Riby, Jacques, Glimelius, Bengt, Hjalgrim, Henrik, Pradhan, Nisha, Feldman, Andrew L., Novak, Anne J., Lawrence, Charles, Bassig, Bryan A., Lan, Qing, Zheng, Tongzhang, North, Kari E., Tinker, Lesley F., Cozen, Wendy, Severson, Richard K., Hofmann, Jonathan N., Zhang, Yawei, Jackson, Rebecca D., Morton, Lindsay M., Purdue, Mark P., Chatterjee, Nilanjan, Offit, Kenneth, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, Vijai, Joseph, Goldin, Lynn R., Skibola, Christine F., and Caporaso, Neil E.
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- 2018
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56. Lifetime prevalence and correlates of perinatal depression in a case-cohort study of depression
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Kiewa, Jacqueline, primary, Meltzer-Brody, Samantha, additional, Milgrom, Jeannette, additional, Bennett, Elizabeth, additional, Mackle, Tracey, additional, Guintivano, Jerry, additional, Hickie, Ian B, additional, Colodro-Conde, Lucia, additional, Medland, Sarah E, additional, Martin, Nick, additional, Wray, Naomi, additional, and Byrne, Enda, additional
- Published
- 2022
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57. Co-option of endogenous retroviruses through genetic escape from TRIM28 repression
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Enriquez-Gasca, Rocio, primary, Gould, Poppy Aeron, additional, Tunbak, Hale, additional, Conde, Lucia, additional, Herrero, Javier, additional, Chittka, Alexandra, additional, Gifford, Robert, additional, and Rowe, Helen M, additional
- Published
- 2022
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58. Heritability of initiation and duration of breastfeeding behavior
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Colodro-Conde, Lucia, Sanchez-Romera, Juan F, and Ordonana, Juan R
- Published
- 2013
59. Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium
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Gibson, Todd M., Smedby, Karin E., Skibola, Christine F., Hein, David W., Slager, Susan L., de Sanjosé, Silvia, Vajdic, Claire M., Zhang, Yawei, Chiu, Brian C.-H., Wang, Sophia S., Hjalgrim, Henrik, Nieters, Alexandra, Bracci, Paige M., Kricker, Anne, Zheng, Tongzhang, Kolar, Carol, Cerhan, James R., Darabi, Hatef, Becker, Nikolaus, Conde, Lucia, Holford, Theodore R., Weisenburger, Dennis D., De Roos, Anneclaire J., Butterbach, Katja, Riby, Jacques, Cozen, Wendy, Benavente, Yolanda, Palmers, Casey, Holly, Elizabeth A., Sampson, Joshua N., Rothman, Nathaniel, Armstrong, Bruce K., and Morton, Lindsay M.
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- 2013
60. Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
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IRAS OH Epidemiology Chemical Agents, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, Rothman, Nathaniel, IRAS OH Epidemiology Chemical Agents, Berndt, Sonja I, Vijai, Joseph, Benavente, Yolanda, Camp, Nicola J, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E, Kleinstern, Geffen, Hjalgrim, Henrik, Besson, Caroline, Skibola, Christine F, Morton, Lindsay M, Brooks-Wilson, Angela R, Teras, Lauren R, Breeze, Charles, Arias, Joshua, Adami, Hans-Olov, Albanes, Demetrius, Anderson, Kenneth C, Ansell, Stephen M, Bassig, Bryan, Becker, Nikolaus, Bhatti, Parveen, Birmann, Brenda M, Boffetta, Paolo, Bracci, Paige M, Brennan, Paul, Brown, Elizabeth E, Burdett, Laurie, Cannon-Albright, Lisa A, Chang, Ellen T, Chiu, Brian C H, Chung, Charles C, Clavel, Jacqueline, Cocco, Pierluigi, Colditz, Graham, Conde, Lucia, Conti, David V, Cox, David G, Curtin, Karen, Casabonne, Delphine, De Vivo, Immaculata, Diver, W Ryan, Dogan, Ahmet, Edlund, Christopher K, Foretova, Lenka, Fraumeni, Joseph F, Gabbas, Attilio, Ghesquières, Hervé, Giles, Graham G, Glaser, Sally, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M, Haiman, Christopher A, Haioun, Corinne, Hofmann, Jonathan N, Holford, Theodore R, Holly, Elizabeth A, Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D, Jarrett, Ruth F, Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N, Kong, Yinfei, Kraft, Peter, Kricker, Anne, Lake, Annette, Lan, Qing, Lawrence, Charles, Li, Dalin, Liebow, Mark, Link, Brian K, Magnani, Corrado, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L, Molina, Thierry J, Monnereau, Alain, Montalvan, Rebecca, North, Kari E, Novak, Anne J, Onel, Kenan, Purdue, Mark P, Rand, Kristin A, Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W, Severson, Richard K, Shanafelt, Tait D, Smith, Martyn T, Smith, Alexandra, Song, Kevin W, Song, Lei, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stephens, Deborah, Sutherland, Heather J, Tkachuk, Kaitlyn, Thompson, Carrie A, Tilly, Hervé, Tinker, Lesley F, Travis, Ruth C, Turner, Jenny, Vachon, Celine M, Vajdic, Claire M, Van Den Berg, Anke, Van Den Berg, David J, Vermeulen, Roel C H, Vineis, Paolo, Wang, Sophia S, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Doo, Nicole Wong, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R, Chanock, Stephen J, Slager, Susan L, and Rothman, Nathaniel
- Published
- 2022
61. Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project
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Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Pietiläinen, Kirsi H, Hur, Yoon-Mi, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos CEM, Ooki, Syuichi, Saudino, Kimberly J, Stazi, Maria A, Fagnani, Corrado, D’Ippolito, Cristina, Nelson, Tracy L, Whitfield, Keith E, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Heikkilä, Kauko, Cutler, Tessa L, Hopper, John L, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Corley, Robin P, Huibregtse, Brooke M, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth JF, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D, Tarnoki, David L, Burt, S Alexandra, Klump, Kelly L, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M, Saffery, Richard, Rasmussen, Finn, Tynelius, Per, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Haworth, Claire MA, Plomin, Robert, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Boomsma, Dorret I, Sørensen, Thorkild IA, Kaprio, Jaakko, and Silventoinen, Karri
- Published
- 2017
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62. Symptoms of Depression and Risk of Low Back Pain: A Prospective Co-Twin Study
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Pinheiro, Marina B., Ferreira, Manuela L., Refshauge, Kathryn, Colodro-Conde, Lucia, González-Javier, Francisca, Hopper, John L., Ordoñana, Juan R., and Ferreira, Paulo H.
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- 2017
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63. Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
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Vesely, Clare, primary, Wong, Yien Ning Sophia, additional, Childs, Alexa, additional, Akarca, Ayse U., additional, Dhami, Pawan, additional, Vaikkinen, Heli, additional, Conde, Lucia, additional, Herrero, Javier, additional, Ogunbiyi, Olagunju, additional, Gander, Amir, additional, Luong, Tu Vinh, additional, Thirlwell, Chrissie, additional, Caplin, Martyn, additional, Toumpanakis, Christos, additional, Peggs, Karl, additional, Quezada, Sergio A., additional, Marafioti, Teresa, additional, and Meyer, Tim, additional
- Published
- 2022
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64. Prediction of human adaptation and performance in underwater environments
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Plaza, Joaquin Colodro, de los Fayos Ruiz, Enrique J. Garces, Garcia, Juan J. Lopez, and Conde, Lucia Colodro
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- 2014
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65. Phenotypic and genetic factors associated with differential consent to record linkage for prescription history in the Australian Genetics of Depression Study
- Author
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Gomez, Lina, primary, Diaz Torres, Santiago, additional, Colodro-Conde, Lucia, additional, Garcia Marin, Luis, additional, Yap, Chloe, additional, Byrne, Enda M., additional, Yengo, Loic, additional, Lind, Penelope A., additional, Wray, Naomi R., additional, Medland, Sarah., additional, Hickie, Ian, additional, Lupton, Michelle, additional, Renteria, Miguel E., additional, Martin, Nicholas G., additional, and Campos, Adrian I, additional
- Published
- 2021
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66. Borderline Personality Disorder and the Big Five: Molecular Genetic Analyses Indicate Shared Genetic Architecture with Neuroticism and Openness
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Streit, Fabian, primary, Witt, Stephanie, additional, Awasthi, Swapnil, additional, Foo, Jerome, additional, Jungkunz, Martin, additional, Frank, Josef, additional, Colodro-Conde, Lucia, additional, Hindley, Guy, additional, Smeland, Olav, additional, Maslahati, Tolou, additional, Schwarze, Cornelia, additional, Schott, Björn, additional, Hartmann, Annette, additional, Giegling, Ina, additional, Zillich, Lea, additional, Sirignano, Lea, additional, Poisel, Eric, additional, Chen, Chi-Hua, additional, Nöthen, Markus, additional, Mobascher, Arian, additional, Rujescu, Dan, additional, Lieb, Klaus, additional, Dahmen, Norbert, additional, Roepke, Stefan, additional, Schmahl, Christian, additional, Bohus, Martin, additional, Ripke, Stephan, additional, Rietschel, Marcella, additional, and Andreassen, Ole, additional
- Published
- 2021
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67. 96. USE AND INTEREST IN PERSONAL GENOMICS AND THEIR RELATIONSHIP WITH GENETIC LITERACY, PERSONAL CHARACTERISTICS, AND ATTITUDES TOWARDS PSYCHIATRIC GENETIC TESTING
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Morosoli, Jose, primary, Conde, Lucia Colodro, additional, and Medland, Sarah E., additional
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- 2021
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68. W35. INDIVIDUAL DIFFERENCES IN DEPRESSIVE SYMPTOMS AFTER THE EARLY RESPONSES TO THE COVID-19 PANDEMIC IN AUSTRALIA
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Conde, Lucia Colodro, primary, Olsen, Catherine, additional, Martin, Nick, additional, Whiteman, David, additional, and Medland, Sarah E., additional
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- 2021
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69. Whole-genome sequencing of single circulating tumor cells from neuroendocrine neoplasms
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Childs, Alexa, primary, Steele, Christopher D, additional, Vesely, Clare, additional, Rizzo, Francesca M, additional, Ensell, Leah, additional, Lowe, Helen, additional, Dhami, Pawan, additional, Vaikkinen, Heli, additional, Luong, Tu Vinh, additional, Conde, Lucia, additional, Herrero, Javier, additional, Caplin, Martyn, additional, Toumpanakis, Christos, additional, Thirlwell, Christina, additional, Hartley, John A, additional, Pillay, Nischalan, additional, and Meyer, Tim, additional
- Published
- 2021
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70. Habilidades de relación social en la escuela
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García, Roberto Fernández, Conde, Lucía Recio, and González, Pilar Ricarte
- Published
- 1999
71. Influencia de la emoción en la conducta y en nuestras relaciones
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Conde, Lucía Recio
- Published
- 1999
72. Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer
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Besson, Caroline, Moore, Amy, Wu, Wenting, Vajdic, Claire M., de Sanjose, Silvia, Camp, Nicola J., Smedby, Karin E., Shanafelt, Tait D., Morton, Lindsay M., Brewer, Jerry D., Zablotska, Lydia, Li, Shengchao A., Chung, Charles C., Teras, Lauren R., Kleinstern, Geffen, Monnereau, Alain, Kane, Eleanor, Benavente, Yolanda, Purdue, Mark P., Birmann, Brenda M., Link, Brian K., Vermeulen, Roel C.H., Spinelli, John J., Albanes, Demetrius, Arslan, Alan A., Miligi, Lucia, Molina, Thierry J., Skibola, Christine F., Zhang, Yawei, Cozen, Wendy, Staines, Anthony, Caporaso, Neil E., Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tinker, Lesley F., Severson, Richard K., Melbye, Mads, Adami, Hans Olov, Glimelius, Bengt, Bracci, Paige M., Conde, Lucia, Glenn, Martha, Curtin, Karen, Lan, Qing, Zheng, Tongzhang, Weinstein, Stephanie, Brooks-Wilson, Angela R., Diver, W. Ryan, Hjalgrim, Henrik, Besson, Caroline, Moore, Amy, Wu, Wenting, Vajdic, Claire M., de Sanjose, Silvia, Camp, Nicola J., Smedby, Karin E., Shanafelt, Tait D., Morton, Lindsay M., Brewer, Jerry D., Zablotska, Lydia, Li, Shengchao A., Chung, Charles C., Teras, Lauren R., Kleinstern, Geffen, Monnereau, Alain, Kane, Eleanor, Benavente, Yolanda, Purdue, Mark P., Birmann, Brenda M., Link, Brian K., Vermeulen, Roel C.H., Spinelli, John J., Albanes, Demetrius, Arslan, Alan A., Miligi, Lucia, Molina, Thierry J., Skibola, Christine F., Zhang, Yawei, Cozen, Wendy, Staines, Anthony, Caporaso, Neil E., Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tinker, Lesley F., Severson, Richard K., Melbye, Mads, Adami, Hans Olov, Glimelius, Bengt, Bracci, Paige M., Conde, Lucia, Glenn, Martha, Curtin, Karen, Lan, Qing, Zheng, Tongzhang, Weinstein, Stephanie, Brooks-Wilson, Angela R., Diver, W. Ryan, and Hjalgrim, Henrik
- Abstract
Background: Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases. Methods: We examined the association between (i) established NMSC susceptibility loci and CLL risk in a meta-analysis including 3100 CLL cases and 7667 controls and (ii) established CLL loci and NMSC risk in a study of 4242 basal cell carcinoma (BCC) cases, 825 squamous cell carcinoma (SCC) cases and 12802 controls. Polygenic risk scores (PRS) for CLL, BCC and SCC were constructed using established loci. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Higher CLL-PRS was associated with increased BCC risk (OR4th-quartile-vs-1stquartile ¼ 1.13, 95% CI: 1.02-1.24, Ptrend ¼ 0.009), even after removing the shared 6p25.3 locus. No association was observed with BCC-PRS and CLL risk (Ptrend ¼ 0.68). These findings support a contributory role for CLL in BCC risk, but not for BCC in CLL risk. Increased CLL risk was observed with higher SCC-PRS (OR4th-quartile-vs-1st-quartile ¼ 1.22, 95% CI: 1.08-1.38, Ptrend ¼ 1.36 × 10-5), which was driven by shared genetic susceptibility at the 6p25.3 locus. Conclusion: These findings highlight the role of pleiotropy regarding the pathogenesis of CLL and NMSC and shows that a single pleiotropic locus, 6p25.3, drives the observed association between genetic susceptibility to SCC and increased CLL risk. The study also provides evidence that genetic susceptibility for CLL increases BCC risk.
- Published
- 2021
73. Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
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Litchfield, Kevin, Reading, James L., Puttick, Clare, Thakkar, Krupa, Abbosh, Chris, Bentham, Robert, Watkins, Thomas B.K., Rosenthal, Rachel, Biswas, Dhruva, Rowan, Andrew, Lim, Emilia, Al Bakir, Maise, Turati, Virginia, Guerra-Assunção, José Afonso, Conde, Lucia, Furness, Andrew J.S., Saini, Sunil Kumar, Hadrup, Sine R., Herrero, Javier, Lee, Se Hoon, Van Loo, Peter, Enver, Tariq, Larkin, James, Hellmann, Matthew D., Turajlic, Samra, Quezada, Sergio A., McGranahan, Nicholas, Swanton, Charles, Litchfield, Kevin, Reading, James L., Puttick, Clare, Thakkar, Krupa, Abbosh, Chris, Bentham, Robert, Watkins, Thomas B.K., Rosenthal, Rachel, Biswas, Dhruva, Rowan, Andrew, Lim, Emilia, Al Bakir, Maise, Turati, Virginia, Guerra-Assunção, José Afonso, Conde, Lucia, Furness, Andrew J.S., Saini, Sunil Kumar, Hadrup, Sine R., Herrero, Javier, Lee, Se Hoon, Van Loo, Peter, Enver, Tariq, Larkin, James, Hellmann, Matthew D., Turajlic, Samra, Quezada, Sergio A., McGranahan, Nicholas, and Swanton, Charles
- Abstract
Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features underpinning CPI sensitization. Here, we collated whole-exome and transcriptomic data for >1,000 CPI-treated patients across seven tumor types, utilizing standardized bioinformatics workflows and clinical outcome criteria to validate multivariable predictors of CPI sensitization. Clonal tumor mutation burden (TMB) was the strongest predictor of CPI response, followed by total TMB and CXCL9 expression. Subclonal TMB, somatic copy alteration burden, and histocompatibility leukocyte antigen (HLA) evolutionary divergence failed to attain pan-cancer significance. Dinucleotide variants were identified as a source of immunogenic epitopes associated with radical amino acid substitutions and enhanced peptide hydrophobicity/immunogenicity. Copy-number analysis revealed two additional determinants of CPI outcome supported by prior functional evidence: 9q34 (TRAF2) loss associated with response and CCND1 amplification associated with resistance. Finally, single-cell RNA sequencing (RNA-seq) of clonal neoantigen-reactive CD8 tumor-infiltrating lymphocytes (TILs), combined with bulk RNA-seq analysis of CPI-responding tumors, identified CCR5 and CXCL13 as T-cell-intrinsic markers of CPI sensitivity.
- Published
- 2021
74. Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
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Gangoso, Ester, primary, Southgate, Benjamin, additional, Bradley, Leanne, additional, Rus, Stefanie, additional, Galvez-Cancino, Felipe, additional, McGivern, Niamh, additional, Güç, Esra, additional, Kapourani, Chantriolnt-Andreas, additional, Byron, Adam, additional, Ferguson, Kirsty M., additional, Alfazema, Neza, additional, Morrison, Gillian, additional, Grant, Vivien, additional, Blin, Carla, additional, Sou, IengFong, additional, Marques-Torrejon, Maria Angeles, additional, Conde, Lucia, additional, Parrinello, Simona, additional, Herrero, Javier, additional, Beck, Stephan, additional, Brandner, Sebastian, additional, Brennan, Paul M., additional, Bertone, Paul, additional, Pollard, Jeffrey W., additional, Quezada, Sergio A., additional, Sproul, Duncan, additional, Frame, Margaret C., additional, Serrels, Alan, additional, and Pollard, Steven M., additional
- Published
- 2021
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75. Deliverable 7.5 Project Final Brochure and Video
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González, Lucía, Dalmas, Sebastien, Caixach, Ariadna, Conde, Lucia, Sánchez, Sergio, and Aulinas, Montse
- Subjects
InformationSystems_INFORMATIONSYSTEMSAPPLICATIONS ,brochure ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,ComputingMilieux_PERSONALCOMPUTING ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,video ,graphic materials ,ComputingMethodologies_ARTIFICIALINTELLIGENCE ,GeneralLiterature_MISCELLANEOUS - Abstract
CHESS SETUP final brochure and video. 
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- 2020
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76. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
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Coleman, Jonathan RI, Peyrot, Wouter J, Purves, Kirstin L, Davis, Katrina AS, Rayner, Christopher, Choi, Shing Wan, Hubel, Christopher, Gaspar, Helena A, Kan, Carol, Van der Auwera, Sandra, Adams, Mark James, Lyall, Donald M, Choi, Karmel W, Dunn, Erin C, Vassos, Evangelos, Danese, Andrea, Maughan, Barbara, Grabe, Hans J, Lewis, Cathryn M, O'Reilly, Paul F, McIntosh, Andrew M, Smith, Daniel J, Wray, Naomi R, Hotopf, Matthew, Eley, Thalia C, Breen, Gerome, Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M, Abdellaoui, Abdel, Adams, Mark J, Agerbo, Esben, Air, Tracy M, Andlauer, Till FM, Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan TF, Bigdeli, Tim B, Binder, Elisabeth B, Bryois, Julien, Buttenschon, Henriette N, Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E, Davies, Gail, Deary, Ian J, Degenhardt, Franziska, Derks, Eske M, Direk, Nese, Dolan, Conor V, Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K, Foo, Jerome C, Forstner, Andreas J, Frank, Josef, Gill, Michael, Goes, Fernando S, Gordon, Scott D, Grove, Jakob, Hall, Lynsey S, Hansen, Christine Soholm, Hansen, Thomas F, Herms, Stefan, Hickie, Ian B, Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M, Howard, David M, Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A, Jorgenson, Eric, Knowles, James A, Kohane, Isaac S, Kraft, Julia, Kretzschmar, Warren W, Kutalik, Zoltan, Li, Yihan, Lind, Penelope A, MacIntyre, Donald J, MacKinnon, Dean F, Maier, Robert M, Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E, Mehta, Divya, Middeldorp, Christel M, Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M, Montgomery, Grant W, Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G, Nyholt, Dale R, Oskarsson, Hogni, Owen, Michael J, Painter, Jodie N, Pedersen, Carsten Bocker, Pedersen, Marianne Giortz, Peterson, Roseann E, Pettersson, Erik, Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A, Qvist, Per, Rice, John P, Riley, Brien P, Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C, Shen, Ling, Shi, Jianxin, Shyn, Stanley I, Sigurdsson, Engilbert, Sinnamon, Grant CB, Smit, Johannes H, Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E, Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A, Thorgeirsson, Thorgeir E, Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, Andres G, Umbricht, Daniel, van Hemert, Albert M, Viktorin, Alexander, Visscher, Peter M, Wang, Yunpeng, Webb, Bradley T, Weinsheimer, Shantel Marie, Wellmann, Jurgen, Willemsen, Gonneke, Witt, Stephanie H, Wu, Yang, Xi, Hualin S, Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T, Berger, Klaus, Boomsma, Dorret I, Cichon, Sven, Dannlowski, Udo, de Geus, EJC, DePaulo, J Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tonu, Hamilton, Steven P, Hayward, Caroline, Heath, Andrew C, Kendler, Kenneth S, Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S, Lucae, Susanne, Madden, Pamela AF, Magnusson, Patrik K, Martin, Nicholas G, Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Mueller-Myhsok, Bertram, Nordentoft, Merete, Noethen, Markus M, O'Donovan, Michael C, Paciga, Sara A, Pedersen, Nancy L, Penninx, Brenda WJH, Perlis, Roy H, Porteous, David J, Potash, James B, Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G, Smoller, Jordan W, Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Volzke, Henry, Weissman, Myrna M, Werge, Thomas, Levinson, Douglas F, Borglum, Anders D, Sullivan, Patrick F, Consortium, Psychiat Genomics, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), Human genetics, APH - Methodology, APH - Digital Health, Adult Psychiatry, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Sociology and Social Gerontology, Complex Trait Genetics, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, N.R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E.M., Abdellaoui, A., Adams, M.J., Agerbo, E., Air, T.M., Andlauer, TFM, Bacanu, S.A., Bækvad-Hansen, M., Beekman, ATF, Bigdeli, T.B., Binder, E.B., Bryois, J., Buttenschøn, H.N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Christensen, J.H., Clarke, T.K., Coleman, JRI, Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G.E., Davies, G., Deary, I.J., Degenhardt, F., Derks, E.M., Direk, N., Dolan, C.V., Dunn, E.C., Eley, T.C., Escott-Price, V., Kiadeh, FFH, Finucane, H.K., Foo, J.C., Forstner, A.J., Frank, J., Gaspar, H.A., Gill, M., Goes, F.S., Gordon, S.D., Grove, J., Hall, L.S., Hansen, C.S., Hansen, T.F., Herms, S., Hickie, I.B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J.J., Hougaard, D.M., Howard, D.M., Ising, M., Jansen, R., Jones, I., Jones, L.A., Jorgenson, E., Knowles, J.A., Kohane, I.S., Kraft, J., Kretzschmar, W.W., Kutalik, Z., Li, Y., Lind, P.A., MacIntyre, D.J., MacKinnon, D.F., Maier, R.M., Maier, W., Marchini, J., Mbarek, H., McGrath, P., McGuffin, P., Medland, S.E., Mehta, D., Middeldorp, C.M., Mihailov, E., Milaneschi, Y., Milani, L., Mondimore, F.M., Montgomery, G.W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M.G., Nyholt, D.R., O'Reilly, P.F., Oskarsson, H., Owen, M.J., Painter, J.N., Pedersen, C.B., Pedersen, M.G., Peterson, R.E., Pettersson, E., Peyrot, W.J., Pistis, G., Posthuma, D., Quiroz, J.A., Qvist, P., Rice, J.P., Riley, B.P., Rivera, M., Mirza, S.S., Schoevers, R., Schulte, E.C., Shen, L., Shi, J., Shyn, S.I., Sigurdsson, E., Sinnamon, GCB, Smit, J.H., Smith, D.J., Stefansson, H., Steinberg, S., Streit, F., Strohmaier, J., Tansey, K.E., Teismann, H., Teumer, A., Thompson, W., Thomson, P.A., Thorgeirsson, T.E., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A.G., Umbricht, D., Van der Auwera, S., van Hemert, A.M., Viktorin, A., Visscher, P.M., Wang, Y., Webb, B.T., Weinsheimer, S.M., Wellmann, J., Willemsen, G., Witt, S.H., Wu, Y., Xi, H.S., Yang, J., Zhang, F., Arolt, V., Baune, B.T., Berger, K., Boomsma, D.I., Cichon, S., Dannlowski, U., de Geus, EJC, DePaulo, J.R., Domenici, E., Domschke, K., Esko, T., Grabe, H.J., Hamilton, S.P., Hayward, C., Heath, A.C., Kendler, K.S., Kloiber, S., Lewis, G., Li, Q.S., Lucae, S., Madden, PAF, Magnusson, P.K., Martin, N.G., McIntosh, A.M., Metspalu, A., Mors, O., Mortensen, P.B., Müller-Myhsok, B., Nordentoft, M., Nöthen, M.M., O'Donovan, M.C., Paciga, S.A., Pedersen, N.L., Penninx, BWJH, Perlis, R.H., Porteous, D.J., Potash, J.B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T.G., Smoller, J.W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M.M., Werge, T., Lewis, C.M., Levinson, D.F., Breen, G., Børglum, A.D., and Sullivan, P.F.
- Subjects
Netherlands Twin Register (NTR) ,0301 basic medicine ,Male ,SYMPTOMS ,Databases, Factual ,Genome-wide association study ,0302 clinical medicine ,Medicine ,Depression (differential diagnoses) ,RISK ,HERITABILITY ,PSYCHIATRIC-DISORDERS ,Middle Aged ,Psychiatry and Mental health ,Major depressive disorder ,Female ,Waist Circumference ,MENTAL-HEALTH ,Psychological trauma ,Clinical psychology ,Adult ,Psychological Trauma ,Genetic correlation ,CHILDHOOD MALTREATMENT ,Article ,EVENTS ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,SDG 3 - Good Health and Well-being ,ADVERSITY ,mental disorders ,SNP ,Humans ,Genetic Predisposition to Disease ,Molecular Biology ,Genetic association ,Aged ,Depressive Disorder, Major ,business.industry ,Heritability ,medicine.disease ,United Kingdom ,ASSOCIATION ANALYSIS ,030104 developmental biology ,BIOLOGICAL INSIGHTS ,Gene-Environment Interaction ,Self Report ,business ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (r g = 0.24, p = 1.8 × 10 -7 versus r g = -0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10 -4 ). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.
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- 2020
77. Genetically Determined Height and Risk of Non-hodgkin Lymphoma
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Moore, Amy, Kane, Eleanor, Wang, Zhaoming, Panagiotou, Orestis A., Teras, Lauren R., Monnereau, Alain, Wong Doo, Nicole, Machiela, Mitchell J., Skibola, Christine F., Slager, Susan L., Salles, Gilles, Camp, Nicola J., Bracci, Paige M., Nieters, Alexandra, Vermeulen, Roel C. H., Vijai, Joseph, Smedby, Karin E., Zhang, Yawei, Vajdic, Claire M., Cozen, Wendy, Spinelli, John J., Hjalgrim, Henrik, Giles, Graham G., Link, Brian K., Clavel, Jacqueline, Arslan, Alan A., Purdue, Mark P., Tinker, Lesley F., Albanes, Demetrius, Ferri, Giovanni M., Habermann, Thomas M., Adami, Hans-Olov, Becker, Nikolaus, Benavente, Yolanda, Bisanzi, Simonetta, Boffetta, Paolo, Brennan, Paul, Brooks-Wilson, Angela R., Canzian, Federico, Conde, Lucia, Cox, David G., Curtin, Karen, Foretova, Lenka, Gapstur, Susan M., Ghesquieres, Herve, Glenn, Martha, Glimelius, Bengt, Jackson, Rebecca D., Lan, Qing, Liebow, Mark, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Morton, Lindsay M., North, Kari E., Offit, Kenneth, Padoan, Marina, Patel, Alpa V., Piro, Sara, Ravichandran, Vignesh, Riboli, Elio, de Sanjose, Silvia, Severson, Richard K., Southey, Melissa C., Staines, Anthony, Stewart, Carolyn, Travis, Ruth C., Weiderpass, Elisabete, Weinstein, Stephanie, Zheng, Tongzhang, Chanock, Stephen J., Chatterjee, Nilanjan, Rothman, Nathaniel, Birmann, Brenda M., Cerhan, James R., Berndt, Sonja I., Moore, Amy, Kane, Eleanor, Wang, Zhaoming, Panagiotou, Orestis A., Teras, Lauren R., Monnereau, Alain, Wong Doo, Nicole, Machiela, Mitchell J., Skibola, Christine F., Slager, Susan L., Salles, Gilles, Camp, Nicola J., Bracci, Paige M., Nieters, Alexandra, Vermeulen, Roel C. H., Vijai, Joseph, Smedby, Karin E., Zhang, Yawei, Vajdic, Claire M., Cozen, Wendy, Spinelli, John J., Hjalgrim, Henrik, Giles, Graham G., Link, Brian K., Clavel, Jacqueline, Arslan, Alan A., Purdue, Mark P., Tinker, Lesley F., Albanes, Demetrius, Ferri, Giovanni M., Habermann, Thomas M., Adami, Hans-Olov, Becker, Nikolaus, Benavente, Yolanda, Bisanzi, Simonetta, Boffetta, Paolo, Brennan, Paul, Brooks-Wilson, Angela R., Canzian, Federico, Conde, Lucia, Cox, David G., Curtin, Karen, Foretova, Lenka, Gapstur, Susan M., Ghesquieres, Herve, Glenn, Martha, Glimelius, Bengt, Jackson, Rebecca D., Lan, Qing, Liebow, Mark, Maynadie, Marc, McKay, James, Melbye, Mads, Miligi, Lucia, Milne, Roger L., Molina, Thierry J., Morton, Lindsay M., North, Kari E., Offit, Kenneth, Padoan, Marina, Patel, Alpa V., Piro, Sara, Ravichandran, Vignesh, Riboli, Elio, de Sanjose, Silvia, Severson, Richard K., Southey, Melissa C., Staines, Anthony, Stewart, Carolyn, Travis, Ruth C., Weiderpass, Elisabete, Weinstein, Stephanie, Zheng, Tongzhang, Chanock, Stephen J., Chatterjee, Nilanjan, Rothman, Nathaniel, Birmann, Brenda M., Cerhan, James R., and Berndt, Sonja I.
- Abstract
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
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- 2020
- Full Text
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78. The genetic architecture of the human cerebral cortex
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Grasby, Katrina L., Jahanshad, Neda, Painter, Jodie N., Colodro-Conde, Lucia, Bralten, Janita, Hibar, Derrek P., Lind, Penelope A., Pizzagalli, Fabrizio, Ching, Christopher R. K., McMahon, Mary Agnes B., Shatokhina, Natalia, Zsembik, Leo C. P., Thomopoulos, Sophia I., Zhu, Alyssa H., Strike, Lachlan T., Agartz, Ingrid, Alhusaini, Saud, Almeida, Marcio A. A., Alnaes, Dag, Amlien, Inge K., Andersson, Micael, Ard, Tyler, Armstrong, Nicola J., Ashley-Koch, Allison, Atkins, Joshua R., Bernard, Manon, Brouwer, Rachel M., Buimer, Elizabeth E. L., Bulow, Robin, Burger, Christian, Cannon, Dara M., Chakravarty, Mallar, Chen, Qiang, Cheung, Joshua W., Couvy-Duchesne, Baptiste, Dale, Anders M., Dalvie, Shareefa, de Araujo, Tania K., de Zubicaray, Greig I., de Zwarte, Sonja M. C., den Braber, Anouk, Doan, Nhat Trung, Dohm, Katharina, Ehrlich, Stefan, Engelbrecht, Hannah-Ruth, Erk, Susanne, Fan, Chun Chieh, Fedko, Iryna O., Foley, Sonya F., Ford, Judith M., Fukunaga, Masaki, Garrett, Melanie E., Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L., Green, Melissa J., Groenewold, Nynke A., Grotegerd, Dominik, Gurholt, Tiril P., Gutman, Boris A., Hansell, Narelle K., Harris, Mathew A., Harrison, Marc B., Haswell, Courtney C., Hauser, Michael, Herms, Stefan, Heslenfeld, Dirk J., Ho, New Fei, Hoehn, David, Hoffmann, Per, Holleran, Laurena, Hoogman, Martine, Hottenga, Jouke-Jan, Ikeda, Masashi, Janowitz, Deborah, Jansen, Iris E., Jia, Tianye, Jockwitz, Christiane, Kanai, Ryota, Karama, Sherif, Kasperaviciute, Dalia, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Klein, Marieke, Knapp, Michael, Knodt, Annchen R., Kramer, Bernd, Lam, Max, Lancaster, Thomas M., Lee, Phil H., Lett, Tristram A., Lewis, Lindsay B., Lopes-Cendes, Iscia, Luciano, Michelle, Macciardi, Fabio, Marquand, Andre F., Mathias, Samuel R., Melzer, Tracy R., Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Moreira, Jose C. V., Muhleisen, Thomas W., Mueller-Myhsok, Bertram, Najt, Pablo, Nakahara, Soichiro, Nho, Kwangsik, Loohuis, Loes M. Olde, Orfanos, Dimitri Papadopoulos, Pearson, John F., Pitcher, Toni L., Putz, Benno, Quide, Yann, Ragothaman, Anjanibhargavi, Rashid, Faisal M., Reay, William R., Redlich, Ronny, Reinbold, Celine S., Repple, Jonathan, Richard, Genevieve, Riedel, Brandalyn C., Risacher, Shannon L., Rocha, Cristiane S., Mota, Nina R., Salminen, Lauren, Saremi, Arvin, Saykin, Andrew J., Schlag, Fenja, Schmaal, Lianne, Schofield, Peter R., Secolin, Rodrigo, Shapland, Chin Yang, Shen, Li, Shin, Jean, Shumskaya, Elena, Sonderby, Ida E., Sprooten, Emma, Tansey, Katherine E., Teumer, Alexander, Thalamuthu, Anbupalam, Tordesillas-Gutierrez, Diana, Turner, Jessica A., Uhlmann, Anne, Vallerga, Costanza L., van der Meer, Dennis, van Donkelaar, Marjolein M. J., van Eijk, Liza, van Erp, Theo G. M., van Haren, Neeltje E. M., van Rooij, Daan, van Tol, Marie-Jose, Veldink, Jan H., Verhoef, Ellen, Walton, Esther, Wang, Mingyuan, Wang, Yunpeng, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., Witt, Stephanie H., Wittfeld, Katharina, Wolf, Christiane, Wolfers, Thomas, Wu, Jing Qin, Yasuda, Clarissa L., Zaremba, Dario, Zhang, Zuo, Zwiers, Marcel P., Artiges, Eric, Assareh, Amelia A., Ayesa-Arriola, Rosa, Belger, Aysenil, Brandt, Christine L., Brown, Gregory G., Cichon, Sven, Curran, Joanne E., Davies, Gareth E., Degenhardt, Franziska, Dennis, Michelle F., Dietsche, Bruno, Djurovic, Srdjan, Doherty, Colin P., Espiritu, Ryan, Garijo, Daniel, Gil, Yolanda, Gowland, Penny A., Green, Robert C., Hausler, Alexander N., Heindel, Walter, Ho, Beng-Choon, Hoffmann, Wolfgang U., Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Jack, Clifford R., Jr., Jang, MiHyun, Jansen, Andreas, Kimbrel, Nathan A., Kolskar, Knut, Koops, Sanne, Krug, Axel, Lim, Kelvin O., Luykx, Jurjen J., Mathalon, Daniel H., Mather, Karen A., Mattay, Venkata S., Matthews, Sarah, Van Son, Jaqueline Mayoral, McEwen, Sarah C., Melle, Ingrid, Morris, Derek W., Mueller, Bryon A., Nauck, Matthias, Nordvik, Jan E., Noethen, Markus M., O'Leary, Daniel S., Opel, Nils, Martinot, Marie-Laure Paillere, Pike, G. Bruce, Preda, Adrian, Quinlan, Erin B., Rasser, Paul E., Ratnakar, Varun, Reppermund, Simone, Steen, Vidar M., Tooney, Paul A., Torres, Fabio R., Veltman, Dick J., Voyvodic, James T., Whelan, Robert, White, Tonya, Yamamori, Hidenaga, Adams, Hieab H. H., Bis, Joshua C., Debette, Stephanie, Decarli, Charles, Fornage, Myriam, Gudnason, Vilmundur, Hofer, Edith, Ikram, M. Arfan, Launer, Lenore, Longstreth, W. T., Lopez, Oscar L., Mazoyer, Bernard, Mosley, Thomas H., Roshchupkin, Gennady V., Satizabal, Claudia L., Schmidt, Reinhold, Seshadri, Sudha, Yang, Qiong, Alvim, Marina K. M., Ames, David, Anderson, Tim J., Andreassen, Ole A., Arias-Vasquez, Alejandro, Bastin, Mark E., Baune, Bernhard T., Beckham, Jean C., Blangero, John, Boomsma, Dorret I., Brodaty, Henry, Brunner, Han G., Buckner, Randy L., Buitelaar, Jan K., Bustillo, Juan R., Cahn, Wiepke, Cairns, Murray J., Calhoun, Vince, Carr, Vaughan J., Caseras, Xavier, Caspers, Svenja, Cavalleri, Gianpiero L., Cendes, Fernando, Corvin, Aiden, Crespo-Facorro, Benedicto, Dalrymple-Alford, John C., Dannlowski, Udo, de Geus, Eco J. C., Deary, Ian J., Delanty, Norman, Depondt, Chantal, Desrivieres, Sylvane, Donohoe, Gary, Espeseth, Thomas, Fernandez, Guillen, Fisher, Simon E., Flor, Herta, Forstner, Andreas J., Francks, Clyde, Franke, Barbara, Glahn, David C., Gollub, Randy L., Grabe, Hans J., Gruber, Oliver, Haberg, Asta K., Hariri, Ahmad R., Hartman, Catharina A., Hashimoto, Ryota, Heinz, Andreas, Henskens, Frans A., Hillegers, Manon H. J., Hoekstra, Pieter J., Holmes, Avram J., Hong, L. Elliot, Hopkins, William D., Pol, Hilleke E. Hulshoff, Jernigan, Terry L., Jonsson, Erik G., Kahn, Rene S., Kennedy, Martin A., Kircher, Tilo T. J., Kochunov, Peter, Kwok, John B. J., Le Hellard, Stephanie, Loughland, Carmel M., Martin, Nicholas G., Martinot, Jean-Luc, McDonald, Colm, McMahon, Katie L., Meyer-Lindenberg, Andreas, Michie, Patricia T., Morey, Rajendra A., Mowry, Bryan, Nyberg, Lars, Oosterlaan, Jaap, Ophoff, Roel A., Pantelis, Christos, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W. J. H., Polderman, Tinca J. C., Posthuma, Danielle, Rietschel, Marcella, Roffman, Joshua L., Rowland, Laura M., Sachdev, Perminder S., Samann, Philipp G., Schall, Ulrich, Schumann, Gunter, Scott, Rodney J., Sim, Kang, Sisodiya, Sanjay M., Smoller, Jordan W., Sommer, Iris E., St Pourcain, Beate, Stein, Dan J., Toga, Arthur W., Trollor, Julian N., Van der Wee, Nic J. A., van't Ent, Dennis, Volzke, Henry, Walter, Henrik, Weber, Bernd, Weinberger, Daniel R., Wright, Margaret J., Zhou, Juan, Stein, Jason L., Thompson, Paul M., Medland, Sarah E., Grasby, Katrina L., Jahanshad, Neda, Painter, Jodie N., Colodro-Conde, Lucia, Bralten, Janita, Hibar, Derrek P., Lind, Penelope A., Pizzagalli, Fabrizio, Ching, Christopher R. K., McMahon, Mary Agnes B., Shatokhina, Natalia, Zsembik, Leo C. P., Thomopoulos, Sophia I., Zhu, Alyssa H., Strike, Lachlan T., Agartz, Ingrid, Alhusaini, Saud, Almeida, Marcio A. A., Alnaes, Dag, Amlien, Inge K., Andersson, Micael, Ard, Tyler, Armstrong, Nicola J., Ashley-Koch, Allison, Atkins, Joshua R., Bernard, Manon, Brouwer, Rachel M., Buimer, Elizabeth E. L., Bulow, Robin, Burger, Christian, Cannon, Dara M., Chakravarty, Mallar, Chen, Qiang, Cheung, Joshua W., Couvy-Duchesne, Baptiste, Dale, Anders M., Dalvie, Shareefa, de Araujo, Tania K., de Zubicaray, Greig I., de Zwarte, Sonja M. C., den Braber, Anouk, Doan, Nhat Trung, Dohm, Katharina, Ehrlich, Stefan, Engelbrecht, Hannah-Ruth, Erk, Susanne, Fan, Chun Chieh, Fedko, Iryna O., Foley, Sonya F., Ford, Judith M., Fukunaga, Masaki, Garrett, Melanie E., Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L., Green, Melissa J., Groenewold, Nynke A., Grotegerd, Dominik, Gurholt, Tiril P., Gutman, Boris A., Hansell, Narelle K., Harris, Mathew A., Harrison, Marc B., Haswell, Courtney C., Hauser, Michael, Herms, Stefan, Heslenfeld, Dirk J., Ho, New Fei, Hoehn, David, Hoffmann, Per, Holleran, Laurena, Hoogman, Martine, Hottenga, Jouke-Jan, Ikeda, Masashi, Janowitz, Deborah, Jansen, Iris E., Jia, Tianye, Jockwitz, Christiane, Kanai, Ryota, Karama, Sherif, Kasperaviciute, Dalia, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Klein, Marieke, Knapp, Michael, Knodt, Annchen R., Kramer, Bernd, Lam, Max, Lancaster, Thomas M., Lee, Phil H., Lett, Tristram A., Lewis, Lindsay B., Lopes-Cendes, Iscia, Luciano, Michelle, Macciardi, Fabio, Marquand, Andre F., Mathias, Samuel R., Melzer, Tracy R., Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Moreira, Jose C. V., Muhleisen, Thomas W., Mueller-Myhsok, Bertram, Najt, Pablo, Nakahara, Soichiro, Nho, Kwangsik, Loohuis, Loes M. Olde, Orfanos, Dimitri Papadopoulos, Pearson, John F., Pitcher, Toni L., Putz, Benno, Quide, Yann, Ragothaman, Anjanibhargavi, Rashid, Faisal M., Reay, William R., Redlich, Ronny, Reinbold, Celine S., Repple, Jonathan, Richard, Genevieve, Riedel, Brandalyn C., Risacher, Shannon L., Rocha, Cristiane S., Mota, Nina R., Salminen, Lauren, Saremi, Arvin, Saykin, Andrew J., Schlag, Fenja, Schmaal, Lianne, Schofield, Peter R., Secolin, Rodrigo, Shapland, Chin Yang, Shen, Li, Shin, Jean, Shumskaya, Elena, Sonderby, Ida E., Sprooten, Emma, Tansey, Katherine E., Teumer, Alexander, Thalamuthu, Anbupalam, Tordesillas-Gutierrez, Diana, Turner, Jessica A., Uhlmann, Anne, Vallerga, Costanza L., van der Meer, Dennis, van Donkelaar, Marjolein M. J., van Eijk, Liza, van Erp, Theo G. M., van Haren, Neeltje E. M., van Rooij, Daan, van Tol, Marie-Jose, Veldink, Jan H., Verhoef, Ellen, Walton, Esther, Wang, Mingyuan, Wang, Yunpeng, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., Witt, Stephanie H., Wittfeld, Katharina, Wolf, Christiane, Wolfers, Thomas, Wu, Jing Qin, Yasuda, Clarissa L., Zaremba, Dario, Zhang, Zuo, Zwiers, Marcel P., Artiges, Eric, Assareh, Amelia A., Ayesa-Arriola, Rosa, Belger, Aysenil, Brandt, Christine L., Brown, Gregory G., Cichon, Sven, Curran, Joanne E., Davies, Gareth E., Degenhardt, Franziska, Dennis, Michelle F., Dietsche, Bruno, Djurovic, Srdjan, Doherty, Colin P., Espiritu, Ryan, Garijo, Daniel, Gil, Yolanda, Gowland, Penny A., Green, Robert C., Hausler, Alexander N., Heindel, Walter, Ho, Beng-Choon, Hoffmann, Wolfgang U., Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Jack, Clifford R., Jr., Jang, MiHyun, Jansen, Andreas, Kimbrel, Nathan A., Kolskar, Knut, Koops, Sanne, Krug, Axel, Lim, Kelvin O., Luykx, Jurjen J., Mathalon, Daniel H., Mather, Karen A., Mattay, Venkata S., Matthews, Sarah, Van Son, Jaqueline Mayoral, McEwen, Sarah C., Melle, Ingrid, Morris, Derek W., Mueller, Bryon A., Nauck, Matthias, Nordvik, Jan E., Noethen, Markus M., O'Leary, Daniel S., Opel, Nils, Martinot, Marie-Laure Paillere, Pike, G. Bruce, Preda, Adrian, Quinlan, Erin B., Rasser, Paul E., Ratnakar, Varun, Reppermund, Simone, Steen, Vidar M., Tooney, Paul A., Torres, Fabio R., Veltman, Dick J., Voyvodic, James T., Whelan, Robert, White, Tonya, Yamamori, Hidenaga, Adams, Hieab H. H., Bis, Joshua C., Debette, Stephanie, Decarli, Charles, Fornage, Myriam, Gudnason, Vilmundur, Hofer, Edith, Ikram, M. Arfan, Launer, Lenore, Longstreth, W. T., Lopez, Oscar L., Mazoyer, Bernard, Mosley, Thomas H., Roshchupkin, Gennady V., Satizabal, Claudia L., Schmidt, Reinhold, Seshadri, Sudha, Yang, Qiong, Alvim, Marina K. M., Ames, David, Anderson, Tim J., Andreassen, Ole A., Arias-Vasquez, Alejandro, Bastin, Mark E., Baune, Bernhard T., Beckham, Jean C., Blangero, John, Boomsma, Dorret I., Brodaty, Henry, Brunner, Han G., Buckner, Randy L., Buitelaar, Jan K., Bustillo, Juan R., Cahn, Wiepke, Cairns, Murray J., Calhoun, Vince, Carr, Vaughan J., Caseras, Xavier, Caspers, Svenja, Cavalleri, Gianpiero L., Cendes, Fernando, Corvin, Aiden, Crespo-Facorro, Benedicto, Dalrymple-Alford, John C., Dannlowski, Udo, de Geus, Eco J. C., Deary, Ian J., Delanty, Norman, Depondt, Chantal, Desrivieres, Sylvane, Donohoe, Gary, Espeseth, Thomas, Fernandez, Guillen, Fisher, Simon E., Flor, Herta, Forstner, Andreas J., Francks, Clyde, Franke, Barbara, Glahn, David C., Gollub, Randy L., Grabe, Hans J., Gruber, Oliver, Haberg, Asta K., Hariri, Ahmad R., Hartman, Catharina A., Hashimoto, Ryota, Heinz, Andreas, Henskens, Frans A., Hillegers, Manon H. J., Hoekstra, Pieter J., Holmes, Avram J., Hong, L. Elliot, Hopkins, William D., Pol, Hilleke E. Hulshoff, Jernigan, Terry L., Jonsson, Erik G., Kahn, Rene S., Kennedy, Martin A., Kircher, Tilo T. J., Kochunov, Peter, Kwok, John B. J., Le Hellard, Stephanie, Loughland, Carmel M., Martin, Nicholas G., Martinot, Jean-Luc, McDonald, Colm, McMahon, Katie L., Meyer-Lindenberg, Andreas, Michie, Patricia T., Morey, Rajendra A., Mowry, Bryan, Nyberg, Lars, Oosterlaan, Jaap, Ophoff, Roel A., Pantelis, Christos, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W. J. H., Polderman, Tinca J. C., Posthuma, Danielle, Rietschel, Marcella, Roffman, Joshua L., Rowland, Laura M., Sachdev, Perminder S., Samann, Philipp G., Schall, Ulrich, Schumann, Gunter, Scott, Rodney J., Sim, Kang, Sisodiya, Sanjay M., Smoller, Jordan W., Sommer, Iris E., St Pourcain, Beate, Stein, Dan J., Toga, Arthur W., Trollor, Julian N., Van der Wee, Nic J. A., van't Ent, Dennis, Volzke, Henry, Walter, Henrik, Weber, Bernd, Weinberger, Daniel R., Wright, Margaret J., Zhou, Juan, Stein, Jason L., Thompson, Paul M., and Medland, Sarah E.
- Abstract
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
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- 2020
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79. Genetic and environmental variation in educational attainment : an individual-based analysis of 28 twin cohorts
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Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Latvala, Antti, Honda, Chika, Inui, Fujio, Tomizawa, Rie, Watanabe, Mikio, Sakai, Norio, Rebato, Esther, Busjahn, Andreas, Tyler, Jessica, Hopper, John L., Ordoñana, Juan R., Sánchez-Romera, Juan F., Colodro-Conde, Lucia, Calais-Ferreira, Lucas, Oliveira, Vinicius C., Ferreira, Paulo H., Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Siribaddana, Sisira H., Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Duncan, Glen E., Buchwald, Dedra, Tynelius, Per, Rasmussen, Finn, Tan, Qihua, Zhang, Dongfeng, Pang, Zengchang, Magnusson, Patrik K. E., Pedersen, Nancy L., Dahl Aslan, Anna K., Hwang, Amie E., Mack, Thomas M., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Brandt, Ingunn, Nilsen, Thomas S., Harris, Jennifer R., Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E. M., Franz, Carol E., Kremen, William S., Lyons, Michael J., Silberg, Judy L., Maes, Hermine H., Kandler, Christian, Nelson, Tracy L., Whitfield, Keith E., Corley, Robin P., Huibregtse, Brooke M., Gatz, Margaret, Butler, David A., Tarnoki, Adam D., Tarnoki, David L., Park, Hang A., Lee, Jooyeon, Lee, Soo Ji, Sung, Joohon, Yokoyama, Yoshie, Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Latvala, Antti, Honda, Chika, Inui, Fujio, Tomizawa, Rie, Watanabe, Mikio, Sakai, Norio, Rebato, Esther, Busjahn, Andreas, Tyler, Jessica, Hopper, John L., Ordoñana, Juan R., Sánchez-Romera, Juan F., Colodro-Conde, Lucia, Calais-Ferreira, Lucas, Oliveira, Vinicius C., Ferreira, Paulo H., Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Siribaddana, Sisira H., Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Duncan, Glen E., Buchwald, Dedra, Tynelius, Per, Rasmussen, Finn, Tan, Qihua, Zhang, Dongfeng, Pang, Zengchang, Magnusson, Patrik K. E., Pedersen, Nancy L., Dahl Aslan, Anna K., Hwang, Amie E., Mack, Thomas M., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Brandt, Ingunn, Nilsen, Thomas S., Harris, Jennifer R., Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E. M., Franz, Carol E., Kremen, William S., Lyons, Michael J., Silberg, Judy L., Maes, Hermine H., Kandler, Christian, Nelson, Tracy L., Whitfield, Keith E., Corley, Robin P., Huibregtse, Brooke M., Gatz, Margaret, Butler, David A., Tarnoki, Adam D., Tarnoki, David L., Park, Hang A., Lee, Jooyeon, Lee, Soo Ji, Sung, Joohon, Yokoyama, Yoshie, Sørensen, Thorkild I. A., Boomsma, Dorret I., and Kaprio, Jaakko
- Abstract
We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural–geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability: a2 = 0.43; 0.41–0.44), but also environmental variation shared by co-twins was substantial (c2 = 0.31; 0.30–0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900–1949 (a2 = 0.44; 0.41–0.46) than in the later cohorts born in 1950–1989 (a2 = 0.38; 0.36–0.40), with a corresponding lower influence of common environmental factors (c2 = 0.31; 0.29–0.33 and c2 = 0.34; 0.32–0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s., CC BY 4.0
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- 2020
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80. Two genetic analyses to elucidate causality in the associations between body mass index and psychological traits
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Arumae, Kadri, Briley, Daniel, Colodro-Conde, Lucia, Mortensen, Erik Lykke, Jang, Kerry, Ando, Juko, Kandler, Christian, Sørensen, Thorkild I. A., Dagher, Alain, Mottus, Rene, Vainik, Uku, Arumae, Kadri, Briley, Daniel, Colodro-Conde, Lucia, Mortensen, Erik Lykke, Jang, Kerry, Ando, Juko, Kandler, Christian, Sørensen, Thorkild I. A., Dagher, Alain, Mottus, Rene, and Vainik, Uku
- Published
- 2020
81. Genetic and environmental variation in educational attainment:an individual-based analysis of 28 twin cohorts
- Author
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Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Latvala, Antti, Honda, Chika, Inui, Fujio, Tomizawa, Rie, Watanabe, Mikio, Sakai, Norio, Rebato, Esther, Busjahn, Andreas, Tyler, Jessica, Hopper, John L., Ordoñana, Juan R., Sánchez-Romera, Juan F., Colodro-Conde, Lucia, Calais-Ferreira, Lucas, Oliveira, Vinicius C., Ferreira, Paulo H., Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J.F., Siribaddana, Sisira H., Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Duncan, Glen E., Buchwald, Dedra, Tynelius, Per, Rasmussen, Finn, Tan, Qihua, Zhang, Dongfeng, Pang, Zengchang, Magnusson, Patrik K.E., Pedersen, Nancy L., Dahl Aslan, Anna K., Hwang, Amie E., Mack, Thomas M., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Brandt, Ingunn, Nilsen, Thomas S., Harris, Jennifer R., Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E.M., Franz, Carol E., Kremen, William S., Lyons, Michael J., Silberg, Judy L., Maes, Hermine H., Kandler, Christian, Nelson, Tracy L., Whitfield, Keith E., Corley, Robin P., Huibregtse, Brooke M., Gatz, Margaret, Butler, David A., Tarnoki, Adam D., Tarnoki, David L., Park, Hang A., Lee, Jooyeon, Lee, Soo Ji, Sung, Joohon, Yokoyama, Yoshie, Sørensen, Thorkild I.A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Latvala, Antti, Honda, Chika, Inui, Fujio, Tomizawa, Rie, Watanabe, Mikio, Sakai, Norio, Rebato, Esther, Busjahn, Andreas, Tyler, Jessica, Hopper, John L., Ordoñana, Juan R., Sánchez-Romera, Juan F., Colodro-Conde, Lucia, Calais-Ferreira, Lucas, Oliveira, Vinicius C., Ferreira, Paulo H., Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J.F., Siribaddana, Sisira H., Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Duncan, Glen E., Buchwald, Dedra, Tynelius, Per, Rasmussen, Finn, Tan, Qihua, Zhang, Dongfeng, Pang, Zengchang, Magnusson, Patrik K.E., Pedersen, Nancy L., Dahl Aslan, Anna K., Hwang, Amie E., Mack, Thomas M., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Brandt, Ingunn, Nilsen, Thomas S., Harris, Jennifer R., Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E.M., Franz, Carol E., Kremen, William S., Lyons, Michael J., Silberg, Judy L., Maes, Hermine H., Kandler, Christian, Nelson, Tracy L., Whitfield, Keith E., Corley, Robin P., Huibregtse, Brooke M., Gatz, Margaret, Butler, David A., Tarnoki, Adam D., Tarnoki, David L., Park, Hang A., Lee, Jooyeon, Lee, Soo Ji, Sung, Joohon, Yokoyama, Yoshie, Sørensen, Thorkild I.A., Boomsma, Dorret I., and Kaprio, Jaakko
- Abstract
We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural–geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability: a2 = 0.43; 0.41–0.44), but also environmental variation shared by co-twins was substantial (c2 = 0.31; 0.30–0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900–1949 (a2 = 0.44; 0.41–0.46) than in the later cohorts born in 1950–1989 (a2 = 0.38; 0.36–0.40), with a corresponding lower influence of common environmental factors (c2 = 0.31; 0.29–0.33 and c2 = 0.34; 0.32–0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s.
- Published
- 2020
82. New Oral Anticoagulants in Atrial Fibrillation
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Cid-Conde, Lucia, primary and Lopez-Castro, Jose, additional
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- 2013
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83. eALPS: Estimating Abundance Levels in Pooled Sequencing Using Available Genotyping Data
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Eskin, Itamar, primary, Hormozdiari, Farhad, additional, Conde, Lucia, additional, Riby, Jacques, additional, Skibola, Chris, additional, Eskin, Eleazar, additional, and Halperin, Eran, additional
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- 2013
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84. Increased Immune-Regulatory Receptor Expression on Effector T Cells as Early Indicators of Relapse Following Autologous Stem Cell Transplantation for Multiple Myeloma
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Lee, Lydia, primary, Alrasheed, Nouf, additional, Khandelwal, Garima, additional, Fitzsimons, Evelyn, additional, Richards, Huw, additional, Wilson, William, additional, Chavda, Selina J., additional, Henry, Jake, additional, Conde, Lucia, additional, De Massy, Marc Robert, additional, Chin, Melody, additional, Galas-Filipowicz, Daria, additional, Herrero, Javier, additional, Chain, Benny, additional, Quezada, Sergio A., additional, and Yong, Kwee, additional
- Published
- 2021
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85. Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
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Litchfield, Kevin, primary, Reading, James L., additional, Puttick, Clare, additional, Thakkar, Krupa, additional, Abbosh, Chris, additional, Bentham, Robert, additional, Watkins, Thomas B.K., additional, Rosenthal, Rachel, additional, Biswas, Dhruva, additional, Rowan, Andrew, additional, Lim, Emilia, additional, Al Bakir, Maise, additional, Turati, Virginia, additional, Guerra-Assunção, José Afonso, additional, Conde, Lucia, additional, Furness, Andrew J.S., additional, Saini, Sunil Kumar, additional, Hadrup, Sine R., additional, Herrero, Javier, additional, Lee, Se-Hoon, additional, Van Loo, Peter, additional, Enver, Tariq, additional, Larkin, James, additional, Hellmann, Matthew D., additional, Turajlic, Samra, additional, Quezada, Sergio A., additional, McGranahan, Nicholas, additional, and Swanton, Charles, additional
- Published
- 2021
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86. Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes
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Moore, Amy, primary, Machiela, Mitchell J., additional, Machado, Moara, additional, Wang, Sophia S., additional, Kane, Eleanor, additional, Slager, Susan L., additional, Zhou, Weiyin, additional, Carrington, Mary, additional, Lan, Qing, additional, Milne, Roger L., additional, Birmann, Brenda M., additional, Adami, Hans-Olov, additional, Albanes, Demetrius, additional, Arslan, Alan A., additional, Becker, Nikolaus, additional, Benavente, Yolanda, additional, Bisanzi, Simonetta, additional, Boffetta, Paolo, additional, Bracci, Paige M., additional, Brennan, Paul, additional, Brooks-Wilson, Angela R., additional, Canzian, Federico, additional, Caporaso, Neil, additional, Clavel, Jacqueline, additional, Cocco, Pierluigi, additional, Conde, Lucia, additional, Cox, David G., additional, Cozen, Wendy, additional, Curtin, Karen, additional, De Vivo, Immaculata, additional, de Sanjose, Silvia, additional, Foretova, Lenka, additional, Gapstur, Susan M., additional, Ghesquières, Hervé, additional, Giles, Graham G., additional, Glenn, Martha, additional, Glimelius, Bengt, additional, Gao, Chi, additional, Habermann, Thomas M., additional, Hjalgrim, Henrik, additional, Jackson, Rebecca D., additional, Liebow, Mark, additional, Link, Brian K., additional, Maynadie, Marc, additional, McKay, James, additional, Melbye, Mads, additional, Miligi, Lucia, additional, Molina, Thierry J., additional, Monnereau, Alain, additional, Nieters, Alexandra, additional, North, Kari E., additional, Offit, Kenneth, additional, Patel, Alpa V., additional, Piro, Sara, additional, Ravichandran, Vignesh, additional, Riboli, Elio, additional, Salles, Gilles, additional, Severson, Richard K., additional, Skibola, Christine F., additional, Smedby, Karin E., additional, Southey, Melissa C., additional, Spinelli, John J., additional, Staines, Anthony, additional, Stewart, Carolyn, additional, Teras, Lauren R., additional, Tinker, Lesley F., additional, Travis, Ruth C., additional, Vajdic, Claire M., additional, Vermeulen, Roel C. H., additional, Vijai, Joseph, additional, Weiderpass, Elisabete, additional, Weinstein, Stephanie, additional, Doo, Nicole Wong, additional, Zhang, Yawei, additional, Zheng, Tongzhang, additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, Cerhan, James R., additional, Dean, Michael, additional, Camp, Nicola J., additional, Yeager, Meredith, additional, and Berndt, Sonja I., additional
- Published
- 2021
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87. X chromosome-wide association study of follicular lymphoma
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Conde, Lucia, Foo, Jia-Nee, Riby, Jacques, Liu, Jianjun, Darabi, Hatef, Hjalgrim, Henrik, Bracci, Paige M., Smedby, Karin E., and Skibola, Christine F.
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- 2013
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88. Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes
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Slager, Susan L., Camp, Nicola J., Conde, Lucia, Shanafelt, Tait D., Achenbach, Sara J., Rabe, Kari G., Kay, Neil E., Novak, Anne J., Call, Timothy G., Bracci, Paige M., Sille, Fenna M. C., Sanchez, Sylvia, Akers, Nicholas K., Cunningham, Julie M., Serie, Daniel J., McDonnell, Shannon K., Leis, Jose F., Wang, Alice H., Weinberg, Brice J., Glenn, Martha, Link, Brian, Vachon, Celine M., Lanasa, Mark C., Skibola, Christine F., and Cerhan, James R.
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- 2012
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89. A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk
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Campa, Daniele, Butterbach, Katja, Slager, Susan L., Skibola, Christine F., de Sanjosé, Silvia, Benavente, Yolanda, Becker, Nikolaus, Foretova, Lenka, Maynadie, Marc, Cocco, Pierluigi, Staines, Anthony, Kaaks, Rudolf, Boffetta, Paolo, Brennan, Paul, Conde, Lucia, Bracci, Paige M., Caporaso, Neil E., Strom, Sara S., Camp, Nicola J., Cerhan, James R., Consortium, GEC, Canzian, Federico, and Nieters, Alexandra
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- 2012
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90. GenomeChronicler: The Personal Genome Project UK Genomic Report Generator Pipeline
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Guerra-Assunção, José Afonso, primary, Conde, Lucia, additional, Moghul, Ismail, additional, Webster, Amy P., additional, Ecker, Simone, additional, Chervova, Olga, additional, Chatzipantsiou, Christina, additional, Prieto, Pablo P., additional, Beck, Stephan, additional, and Herrero, Javier, additional
- Published
- 2020
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91. Meta-analysis of tumor and T cell intrinsic mechanisms of sensitization to checkpoint inhibition
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Litchfield, Kevin, primary, Reading, James L., additional, Puttick, Clare, additional, Abbosh, Chris, additional, Bentham, Robert, additional, Watkins, Thomas B. K., additional, Rosenthal, Rachel, additional, Biswas, Dhruva, additional, Lim, Emilia, additional, AL-Bakir, Maise, additional, Turati, Virginia, additional, Guerra-Assunção, José Afonso, additional, Conde, Lucia, additional, Furness, Andrew J.S., additional, Saini, Sunil Kumar, additional, Hadrup, Sine R, additional, Herrero, Javier, additional, Rowan, Andrew, additional, Enver, Tariq, additional, Hellmann, Matthew D., additional, Larkin, James, additional, Turajlic, Samra, additional, Quezada, Sergio, additional, McGranahan, Nicholas, additional, and Swanton, Charles, additional
- Published
- 2020
- Full Text
- View/download PDF
92. Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts
- Author
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Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Latvala, Antti, additional, Honda, Chika, additional, Inui, Fujio, additional, Tomizawa, Rie, additional, Watanabe, Mikio, additional, Sakai, Norio, additional, Rebato, Esther, additional, Busjahn, Andreas, additional, Tyler, Jessica, additional, Hopper, John L., additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Calais-Ferreira, Lucas, additional, Oliveira, Vinicius C., additional, Ferreira, Paulo H., additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, Toccaceli, Virgilia, additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Tynelius, Per, additional, Rasmussen, Finn, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Dahl Aslan, Anna K., additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Brandt, Ingunn, additional, Nilsen, Thomas S., additional, Harris, Jennifer R., additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina E. M., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Silberg, Judy L., additional, Maes, Hermine H., additional, Kandler, Christian, additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Gatz, Margaret, additional, Butler, David A., additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Park, Hang A., additional, Lee, Jooyeon, additional, Lee, Soo Ji, additional, Sung, Joohon, additional, Yokoyama, Yoshie, additional, Sørensen, Thorkild I. A., additional, Boomsma, Dorret I., additional, and Kaprio, Jaakko, additional
- Published
- 2020
- Full Text
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93. Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4+PD-1+ Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma
- Author
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Alrasheed, Nouf, primary, Lee, Lydia, additional, Ghorani, Ehsan, additional, Henry, Jake Y., additional, Conde, Lucia, additional, Chin, Melody, additional, Galas-Filipowicz, Daria, additional, Furness, Andrew J.S., additional, Chavda, Selina J., additional, Richards, Huw, additional, De-Silva, Dunnya, additional, Cohen, Oliver C., additional, Patel, Dominic, additional, Brooks, Anthony, additional, Rodriguez-Justo, Manuel, additional, Pule, Martin, additional, Herrero, Javier, additional, Quezada, Sergio A., additional, and Yong, Kwee L., additional
- Published
- 2020
- Full Text
- View/download PDF
94. Cohort profile: the Australian genetics of depression study
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Byrne, Enda M, primary, Kirk, Katherine M, additional, Medland, Sarah E, additional, McGrath, John J, additional, Colodro-Conde, Lucia, additional, Parker, Richard, additional, Cross, Simone, additional, Sullivan, Lenore, additional, Statham, Dixie J, additional, Levinson, Douglas F, additional, Licinio, Julio, additional, Wray, Naomi R, additional, Hickie, Ian B, additional, and Martin, Nicholas G, additional
- Published
- 2020
- Full Text
- View/download PDF
95. Genetically Determined Height and Risk of Non-hodgkin Lymphoma
- Author
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Moore, Amy, primary, Kane, Eleanor, additional, Wang, Zhaoming, additional, Panagiotou, Orestis A., additional, Teras, Lauren R., additional, Monnereau, Alain, additional, Wong Doo, Nicole, additional, Machiela, Mitchell J., additional, Skibola, Christine F., additional, Slager, Susan L., additional, Salles, Gilles, additional, Camp, Nicola J., additional, Bracci, Paige M., additional, Nieters, Alexandra, additional, Vermeulen, Roel C. H., additional, Vijai, Joseph, additional, Smedby, Karin E., additional, Zhang, Yawei, additional, Vajdic, Claire M., additional, Cozen, Wendy, additional, Spinelli, John J., additional, Hjalgrim, Henrik, additional, Giles, Graham G., additional, Link, Brian K., additional, Clavel, Jacqueline, additional, Arslan, Alan A., additional, Purdue, Mark P., additional, Tinker, Lesley F., additional, Albanes, Demetrius, additional, Ferri, Giovanni M., additional, Habermann, Thomas M., additional, Adami, Hans-Olov, additional, Becker, Nikolaus, additional, Benavente, Yolanda, additional, Bisanzi, Simonetta, additional, Boffetta, Paolo, additional, Brennan, Paul, additional, Brooks-Wilson, Angela R., additional, Canzian, Federico, additional, Conde, Lucia, additional, Cox, David G., additional, Curtin, Karen, additional, Foretova, Lenka, additional, Gapstur, Susan M., additional, Ghesquières, Hervé, additional, Glenn, Martha, additional, Glimelius, Bengt, additional, Jackson, Rebecca D., additional, Lan, Qing, additional, Liebow, Mark, additional, Maynadie, Marc, additional, McKay, James, additional, Melbye, Mads, additional, Miligi, Lucia, additional, Milne, Roger L., additional, Molina, Thierry J., additional, Morton, Lindsay M., additional, North, Kari E., additional, Offit, Kenneth, additional, Padoan, Marina, additional, Patel, Alpa V., additional, Piro, Sara, additional, Ravichandran, Vignesh, additional, Riboli, Elio, additional, de Sanjose, Silvia, additional, Severson, Richard K., additional, Southey, Melissa C., additional, Staines, Anthony, additional, Stewart, Carolyn, additional, Travis, Ruth C., additional, Weiderpass, Elisabete, additional, Weinstein, Stephanie, additional, Zheng, Tongzhang, additional, Chanock, Stephen J., additional, Chatterjee, Nilanjan, additional, Rothman, Nathaniel, additional, Birmann, Brenda M., additional, Cerhan, James R., additional, and Berndt, Sonja I., additional
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- 2020
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96. Joint annotation of coding and non-coding single nucleotide polymorphisms and mutations in the SNPeffect and PupaSuite databases
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Reumers, Joke, Conde, Lucia, Medina, Ignacio, Maurer-Stroh, Sebastian, Van Durme, Joost, Dopazo, Joaquin, Rousseau, Frederic, and Schymkowitz, Joost
- Published
- 2008
97. Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci
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Dudding, Tom, Haworth, Simon, Lind, Penelope A., Sathirapongsasuti, J. Fah, Tung, Joyce Y., Mitchell, Ruth, Colodro-Conde, Lucia, Medland, Sarah E., Gordon, Scott, Elsworth, Benjamin, Paternoster, Lavinia, Franks, Paul W., Thomas, Steven J., Martin, Nicholas G., Timpson, Nicholas J., Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Jiang, Yunxuan, Kleinman, Aaron, Lin, Keng-Han, Litterman, Nadia K., McCeight, Jennifer C., McIntyre, Matthew H., McManus, Kimberly F., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A. M., Pitts, Steven J., Poznik, David, Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Vacic, Vladimir, Wang, Xin, Wilson, Catherine H., Dudding, Tom, Haworth, Simon, Lind, Penelope A., Sathirapongsasuti, J. Fah, Tung, Joyce Y., Mitchell, Ruth, Colodro-Conde, Lucia, Medland, Sarah E., Gordon, Scott, Elsworth, Benjamin, Paternoster, Lavinia, Franks, Paul W., Thomas, Steven J., Martin, Nicholas G., Timpson, Nicholas J., Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Jiang, Yunxuan, Kleinman, Aaron, Lin, Keng-Han, Litterman, Nadia K., McCeight, Jennifer C., McIntyre, Matthew H., McManus, Kimberly F., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A. M., Pitts, Steven J., Poznik, David, Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Vacic, Vladimir, Wang, Xin, and Wilson, Catherine H.
- Abstract
Mouth ulcers are the most common ulcerative condition and encompass several clinical diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous evidence for heritability, it is not clear which specific genetic loci are implicated in RAS. In this genome-wide association study (n = 461,106) heritability is estimated at 8.2% (95% CI: 6.4%, 9.9%). This study finds 97 variants which alter the odds of developing non-specific mouth ulcers and replicate these in an independent cohort (n = 355,744) (lead variant after meta-analysis: rs76830965, near IL12A, OR 0.72 (95% CI: 0.71, 0.73); P = 4.4e-483). Additional effect estimates from three independent cohorts with more specific phenotyping and specific study characteristics support many of these findings. In silico functional analyses provide evidence for a role of T cell regulation in the aetiology of mouth ulcers. These results provide novel insight into the pathogenesis of a common, important condition.
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- 2019
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98. Personality Characteristics Below Facets:A Replication and Meta-Analysis of Cross-Rater Agreement, Rank-Order Stability, Heritability, and Utility of Personality Nuances
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Mottus, Rene, Sinick, Jonah, Terracciano, Antonio, Hrebickova, Martina, Kandler, Christian, Ando, Juko, Mortensen, Erik Lykke, Colodro-Conde, Lucia, Jang, Kerry L., Mottus, Rene, Sinick, Jonah, Terracciano, Antonio, Hrebickova, Martina, Kandler, Christian, Ando, Juko, Mortensen, Erik Lykke, Colodro-Conde, Lucia, and Jang, Kerry L.
- Published
- 2019
99. Personality-obesity associations are driven by narrow traits:A meta-analysis
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Vainik, Uku, Dagher, Alain, Realo, Anu, Colodro-Conde, Lucia, Mortensen, Erik Lykke, Jang, Kerry, Juko, Ando, Kandler, Christian, Sørensen, Thorkild I. A., Mottus, Rene, Vainik, Uku, Dagher, Alain, Realo, Anu, Colodro-Conde, Lucia, Mortensen, Erik Lykke, Jang, Kerry, Juko, Ando, Kandler, Christian, Sørensen, Thorkild I. A., and Mottus, Rene
- Published
- 2019
100. Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangement
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Rodríguez-Perales, Sandra, Meléndez, Bárbara, Gribble, Susan M., Valle, Laura, Carter, Nigel P., Santamaría, Iñigo, Conde, Lucia, Urioste, Miguel, Benítez, Javier, and Cigudosa, Juan C.
- Published
- 2004
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