51. Use of ICRF-187 for prevention of anthracycline cardiotoxicity in children: Preliminary results
- Author
-
Giulia Varrasso, Amalia Schiavetti, A. Padula, V. Colloridi, F. Ventriglia, Manuel A. Castello, P. Versacci, and B. Werner
- Subjects
Cardiac function curve ,Male ,medicine.medical_specialty ,Anthracycline ,Adolescent ,Daunorubicin ,medicine.medical_treatment ,cardiotoxicity ,anthracycline ,Gastroenterology ,Cardiovascular System ,Internal medicine ,Neoplasms ,medicine ,Humans ,Doxorubicin ,Drug Interactions ,Child ,Epirubicin ,Cardiotoxicity ,Chemotherapy ,Antibiotics, Antineoplastic ,business.industry ,Infant ,Cardiovascular Agents ,Hematology ,icrf-187 ,Surgery ,Oncology ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,Dexrazoxane ,business ,Razoxane ,medicine.drug - Abstract
The objective of this study is to assess the efficacy of ICRF-187 as a protective agent against anthracycline cardiotoxicity. Cardiac function was evaluated by echocardiography before and after each cycle of anthracycline chemotherapy associated with ICRF-187 and compared with that of a second group receiving anthracycline chemotherapy without ICRF-187. The patients were a group of 15 consecutive children affected with various types of solid tumors who were treated with either doxorubicin-daunomycin or epirubicin (average doses 340 and 280 mg/m2, respectively), and treatment was associated with ICRF-187. A second group of 15 consecutive children affected with different malignancies were simultaneously treated with either doxorubicin-daunomycin or epirubicin (average doses 309 and 270 mg/m2, respectively), but without ICRF-187 association. None of the patients treated with anthracyclines and ICRF-187 association showed abnormalities on echocardiographic examination. In the second group of patients treated with anthracyclines but without ICRF-187 association, we observed a decrease in the left ventricular ejection fraction to55% and a decrease in the left ventricular fractional shortening to28% in two patients (13.3%). One of these (6.6%) showed a dilatative cardiomyopathy. Both groups of patients were treated with low doses of anthracyclines. Although this study was not randomized, in patients without ICRF-87 cardioprotection, there was a trend for a worse evolution with one case of clinical cardiomyopathy as well as subclinical cardiac abnormalities.
- Published
- 1997