Search

The kinematic Sunyaev--Zel'dovich (kSZ) effect induces a non-zero density-density-temperature bispectrum, which we can use to reconstruct the large-scale velocity field from a combination of cosmic microwave background (CMB) and galaxy density measurements, in a procedure known as ``kSZ velocity reconstruction''. This method has been forecast to constrain large-scale modes with future galaxy and CMB surveys, improving their measurement beyond what is possible with the galaxy surveys alone. Such measurements will enable tighter constraints on large-scale signals such as primordial non-Gaussianity, deviations from homogeneity, and modified gravity. In this work, we demonstrate a statistically significant measurement of kSZ velocity reconstruction for the first time, by applying quadratic estimators to the combination of the ACT DR6 CMB+kSZ map and the DESI LRG galaxies (with photometric redshifts) in order to reconstruct the velocity field. We do so using a formalism appropriate for the 2-dimensional projected galaxy fields that we use, which naturally incorporates the curved-sky effects important on the largest scales. We find evidence for the signal by cross-correlating with an external estimate of the velocity field from the spectroscopic BOSS survey and rejecting the null (no-kSZ) hypothesis at $3.8\sigma$. Our work presents a first step towards the use of this observable for cosmological analyses., Comment: 16 pages (main)+5 pages (Appendix); 13 figures (main) + 8 figures (appendix)

Annual North Atlantic tropical cyclone (TC) counts are frequently modeled as a Poisson process with a state-dependent rate. We provide a lower bound on the forecasting error of this class of models. Remarkably we find that this bound is already saturated by a simple linear model that explains roughly 50 percent of the annual variance using three climate indices: El Ni\~no Southern Oscillation (ENSO), average sea surface temperature (SST) in the main development region (MDR) of the North Atlantic and the North Atlantic oscillation (NAO) atmospheric circulation index (Kozar et al 2012). As expected under the bound, increased model complexity does not help: we demonstrate that allowing for quadratic and interaction terms, or using an Elastic Net to forecast TC counts using global SST maps, produces no detectable increase in skill. We provide evidence that observed TC counts are consistent with a Poisson process, limiting possible improvements in TC modeling by relaxing the Poisson assumption., Comment: 13 pages, 2 figures, submitted to Geophysical Research Letters

The simulation of quantum systems is one of the flagship applications of near-term NISQ (noisy intermediate-scale quantum) computing devices. Efficiently simulating the rich, non-unitary dynamics of open quantum systems remains challenging on NISQ hardware. Current simulation methods for open quantum systems employ time-stepped Trotter product formulas ("Trotterization") which can scale poorly with respect to the simulation time and system dimension. Here, we propose a new simulation method based on the derivation of a Kraus operator series representation of the system. We identify a class of open quantum systems for which this method produces circuits of time-independent depth, which may serve as a desirable alternative to Trotterization, especially on NISQ devices., Comment: 21 pages, 13 figures

Bipartite entanglement entropy is one of the most useful characterizations of universal properties in a many-body quantum system. Far from equilibrium, there exist two highly effective theories describing its dynamics -- the quasiparticle and membrane pictures. In this work we investigate entanglement dynamics, and these two complementary approaches, in a quantum circuit model perturbed by an impurity. In particular, we consider a dual unitary quantum circuit containing a spatially fixed, non-dual-unitary impurity gate, allowing for differing local Hilbert space dimensions to either side. We compute the entanglement entropy for both a semi-infinite and a finite subsystem within a finite distance of the impurity, comparing exact results to predictions of the effective theories. We find that for a semi-infinite subsystem, both theories agree with each other and the exact calculation. For a finite subsystem, however, both theories qualitatively differ, with the quasiparticle picture predicting a non-monotonic growth in contrast to the membrane picture. We show that such non-monotonic behavior can arise even in random chaotic circuits, pointing to a hitherto unknown shortcoming of the membrane picture in describing such systems., Comment: 5+7 pages, 2+1 figures. v2: Added a section to the Supplemental Material, updated acknowledgments; 5+9 pages, 2+3 figures

The Visual Monitoring Camera (VMC) is a small imaging instrument onboard Mars Express with a field of view of ~40x30 degrees. The camera was initially intended to provide visual confirmation of the separation of the Beagle 2 lander and has similar technical specifications to a typical webcam of the 2000s. In 2007, a few years after the end of its original mission, VMC was turned on again to obtain full-disk images of Mars to be used for outreach purposes. As VMC obtained more images, the scientific potential of the camera became evident, and in 2018 the camera was given an upgraded status of a new scientific instrument, with science goals in the field of Martian atmosphere meteorology. The wide Field of View of the camera combined with the orbit of Mars Express enable the acquisition of full-disk images of the planet showing different local times, which for a long time has been rare among orbital missions around Mars. The small data volume of images also allows videos that show the atmospheric dynamics of dust and cloud systems to be obtained. This paper is intended to be the new reference paper for VMC as a scientific instrument, and thus provides an overview of the updated procedures to plan, command and execute science observations of the Martian atmosphere. These observations produce valuable science data that is calibrated and distributed to the community for scientific use.

We obtain a complete classification of the continuous unitary representations of the isometry group of the rational Urysohn space $\mathbb{Q}\mathbb{U}$. As a consequence, we show that Isom$(\mathbb{Q}\mathbb{U})$ has property (T). We also derive several ergodic theoretic consequences from this classification: $(i)$ every probability measure-preserving action of Isom$(\mathbb{Q}\mathbb{U})$ is either essentially free or essentially transitive, $(ii)$ every ergodic Isom$(\mathbb{Q}\mathbb{U})$-invariant probability measure on $[0,1]^{\mathbb{Q}\mathbb{U}}$ is a product measure. We obtain the same results for isometry groups of variations of $\mathbb{Q}\mathbb{U}$, such as the rational Urysohn sphere $\mathbb{Q}\mathbb{U}_1$, the integral Urysohn space $\mathbb{Z}\mathbb{U}$, etc.

A turn constrained vehicle is initially located inside a polygon region and desires to escape in minimum time. First, the method of characteristics is used to describe the time-optimal strategies for reaching a line of infinite length. Next, the approach is extended to polygons constructed of a series of line segments. Using this construction technique, the min-time path to reach each edge is obtained; the resulting minimum of the set of optimal trajectories is then selected for escaping the polygon., Comment: 7 Pages, 6 Figures, Submitted to IFAC ACC, DISTRIBUTION STATEMENT A. Approved for public release. Distribution is unlimited; AFRL-2024-5262. This work is funded in-part by AFOSR, LRIR 24RQCOR002

We present the formation histories of 19 massive ($\gtrsim3\times10^{10}\text{M}_\odot$) quiescent galaxy candidates at $z\sim3.0-4.5$ observed using JWST/NIRSpec. This completes the spectroscopic confirmation of the 24 $K$-selected quiescent galaxy sample from the ZFOURGE and 3DHST surveys \citep{Schreiber2018}. Utilizing Prism $1-5\mu$m spectroscopy, we confirm that all 12 sources that eluded confirmation by ground-based spectroscopy lie at $z>3$, resulting in a spectroscopically confirmed number density of $\sim1.4\times10^{-5}\text{Mpc}^{-3}$ between $z\sim3-4$. Rest-frame $U-V$ vs $V-J$ color selections show high effectiveness in identifying quiescent galaxies, with a purity of $\sim90\%$. Our analysis shows that parametric star-formation histories (SFHs) from FAST++ and binned SFHs from Prospector on average yield consistent results, revealing diverse formation and quenching times. The oldest galaxy formed $\sim6\times10^{10}\text{M}_\odot$ by $z\sim10$ and has been quiescent for over 1 Gyr at $z\sim3.2$. We detect two galaxies with ongoing star formation and six with active galactic nuclei (AGN). We demonstrate that the choice of stellar population models, stellar libraries, wavelength range, and nebular or AGN contributions does not significantly affect the derived average SFHs of the galaxies. The assumed SFH prior, however, influences the star formation rate at early times, where spectral diagnostic power is limited. Simulated $z\sim3$ quiescent galaxies from IllustrisTNG, SHARK, and Magneticum broadly match the average SFHs of the observed sample but struggle to capture the full diversity, particularly at early stages. Our results emphasize the need for mechanisms that rapidly build stellar mass and quench star formation within the first billion years of the Universe., Comment: Submitted to ApJ. Comments welcome

Significant advancements have been made in understanding the physics of transition-edge sensors (TESs) over the past decade. However, key questions remain, particularly a detailed understanding of the current-dependent resistance of these detectors when biased within their superconducting transition. We use scanning superconducting quantum interference device (SQUID) microscopy (SSM) to image the local diamagnetic response of aluminum-manganese alloy (Al-Mn) transition-edge sensors (TESs) near their critical temperature of approximately 175 mK. By doing so, we gain insights into how the device dimensions influence TES transition width, which in turn affects device operation and informs optimal device design. Our images reveal that the Al-Mn thin film near the niobium (Nb) leads exhibits an excess diamagnetic response at temperatures several milli-Kelvin (mK) higher than the bulk of the film farther from the contacts. A possible origin of this behavior is a longitudinal proximity effect between the Nb and Al-Mn where the TES acts as a weak link between superconducting leads. We discuss how this effect shapes the temperature dependence of the resistance as the spacing between the leads decreases. This work demonstrates that magnetic imaging with SSM is a powerful tool for local characterization of superconducting detectors., Comment: 5 pages, 4 figures, Applied Superconductivity Conference (ASC 2024) proceedings, submitted to IEEE Transactions on Applied Superconductivity (IEEE TAS)

We introduce stratified toposes, which are toposes that are stratified by a suitable hierarchy of universes. The term `stratified topos' recalls the notion of stratified pseudotopos of Moerdijk and Palmgren (2002). However, the details of our proposal are closer to that of Streicher (2005), with the foundational contribution being a strengthening of Streicher's axioms. As such, stratified toposes model the calculus of constructions. Key results about toposes can be refined to yield results about stratified toposes. As proof of concept, we construct what we call the stratified topos of coalgebras for a stratified Cartesian comonad on a stratified topos. This construction refines that of the topos of coalgebras for a Cartesian comonad on a topos. Coalgebra constructions in related settings were given by Warren (2007) and Zwanziger (2023). This coalgebra construction exposes conditions under which generic monomorphisms and dense subcategories can be lifted to coalgebras, which are extracted in the appendix., Comment: 39 pages

Superfast rotators (SFRs) are small solar system objects that rotate faster than generally possible for a cohesionless rubble pile. Their rotational characteristics allow us to make inferences about their interior structure and composition. Here, we present the methods and results from a preliminary search for SFRs in the DECam Ecliptic Exploration Project (DEEP) data set. We find three SFRs from a sample of 686 main-belt asteroids, implying an occurrence rate of 0.4 -0.3/+0.1 percent - a higher incidence rate than has been measured by previous studies. We suggest that this high occurrence rate is due to the small sub-kilometer size regime to which DEEP has access: the objects searched here were as small as 500 m. We compute the minimum required cohesive strength for each of these SFRs and discuss the implications of these strengths in the context of likely evolution mechanisms. We find that all three of these SFRs require strengths that are more than that of weak regolith but consistent with many cohesive asteroid strengths reported in the literature. Across the full DEEP data set, we have identified ~70,000 Main-Belt Asteroids and expect ~300 SFRs - a result that will be assessed in a future paper.

This paper investigates the impact of verbose LLM translations on evaluation. We first demonstrate the prevalence of this behavior across several LLM outputs drawn from the WMT 2024 general shared task on machine translation. We then identify the primary triggers of verbosity, including safety, copyright concerns, and insufficient context in short input queries. Finally, we show that ignoring this behavior unfairly penalizes more verbose LLMs according to both automatic and human evaluations, highlighting the need to address this issue for more accurate future evaluations.

The basic crossing number problem is to determine the minimum number of crossings in a topological drawing of an input graph in the plane. In this paper, we develop fixed-parameter tractable (FPT) algorithms for various generalized crossing number problems in the plane or on surfaces. Our first result is on the color-constrained crossing problem, in which edges of the input graph G are colored, and one looks for a drawing of G in the plane or on a given surface in which the total number of crossings involving edges of colors i and j does not exceed a given upper bound Mij. We give an algorithm for this problem that is FPT in the total number of crossings allowed and the genus of the surface. It readily implies an FPT algorithm for the joint crossing number problem. We also give new FPT algorithms for several other graph drawing problems, such as the skewness, the edge crossing number, the splitting number, the gap-planar crossing number, and their generalizations to surfaces. Our algorithms are reductions to the embeddability of a graph on a two-dimensional simplicial complex, which admits an FPT algorithm by a result of Colin de Verdi\`ere and Magnard [ESA 2021].

Modern high performance computers are massively parallel; for many PDE applications spatial parallelism saturates long before the computer's capability is reached. Parallel-in-time methods enable further speedup beyond spatial saturation by solving multiple timesteps simultaneously to expose additional parallelism. ParaDiag is a particular approach to parallel-in-time based on preconditioning the simultaneous timestep system with a perturbation that allows block diagonalisation via a Fourier transform in time. In this article, we introduce asQ, a new library for implementing ParaDiag parallel-in-time methods, with a focus on applications in the geosciences, especially weather and climate. asQ is built on Firedrake, a library for the automated solution of finite element models, and the PETSc library of scalable linear and nonlinear solvers. This enables asQ to build ParaDiag solvers for general finite element models and provide a range of solution strategies, making testing a wide array of problems straightforward. We use a quasi-Newton formulation that encompasses a range of ParaDiag methods, and expose building blocks for constructing more complex methods. The performance and flexibility of asQ is demonstrated on a hierarchy of linear and nonlinear atmospheric flow models. We show that ParaDiag can offer promising speedups and that asQ is a productive testbed for further developing these methods., Comment: 30 pages, 15 figures. To be submitted to journal

Merging has become a widespread way to cheaply combine individual models into a single model that inherits their capabilities and attains better performance. This popularity has spurred rapid development of many new merging methods, which are typically validated in disparate experimental settings and frequently differ in the assumptions made about model architecture, data availability, and computational budget. In this work, we characterize the relative merits of different merging methods by evaluating them in a shared experimental setting and precisely identifying the practical requirements of each method. Specifically, our setting focuses on using merging for compositional generalization of capabilities in image classification, image generation, and natural language processing. Additionally, we measure the computational costs of different merging methods as well as how they perform when scaling the number of models being merged. Taken together, our results clarify the state of the field of model merging and provide a comprehensive and rigorous experimental setup to test new methods.

As highlighted in the National Spectrum Strategy, Dynamic Spectrum Access (DSA) is key for enabling 6G networks to meet the increasing demand for spectrum from various, heterogeneous emerging applications. In this paper, we consider heterogeneous wireless networks with multiple 6G base stations (BS) and a limited number of frequency bands available for transmission. Each BS is associated with a geographical location, a coverage area, and a bandwidth requirement. We assume that clients/UEs are within the corresponding BS's coverage area. To avoid interference, we impose that BSs with overlapping coverage areas must use different frequency bands. We address the challenging problem of efficiently allocating contiguous frequency bands to BSs while avoiding interference. Specifically, we define performance metrics that capture the feasibility of the frequency allocation task, the number of BSs that can be allocated within the limited frequency bands, and the amount of resources utilized by the network. Then, we consider five different DSA algorithms that prioritize BSs based on different features - one of these algorithms is known in the graph theory literature as Welsh-Powell graph colouring algorithm - and compare their performance using extensive simulations. Our results show that DSA algorithms that attempt to maximize the chances of obtaining a feasible frequency allocation - which have been widely studied in the literature - tend to under-perform in all other metrics.

Integrating deep learning into medical imaging is poised to greatly advance diagnostic methods but it faces challenges with generalizability. Foundation models, based on self-supervised learning, address these issues and improve data efficiency. Natural domain foundation models show promise for medical imaging, but systematic research evaluating domain adaptation, especially using self-supervised learning and parameter-efficient fine-tuning, remains underexplored. Additionally, little research addresses the issue of catastrophic forgetting during fine-tuning of foundation models. We adapted the DINOv2 vision transformer for retinal imaging classification tasks using self-supervised learning and generated two novel foundation models termed DINORET and BE DINORET. Publicly available color fundus photographs were employed for model development and subsequent fine-tuning for diabetic retinopathy staging and glaucoma detection. We introduced block expansion as a novel domain adaptation strategy and assessed the models for catastrophic forgetting. Models were benchmarked to RETFound, a state-of-the-art foundation model in ophthalmology. DINORET and BE DINORET demonstrated competitive performance on retinal imaging tasks, with the block expanded model achieving the highest scores on most datasets. Block expansion successfully mitigated catastrophic forgetting. Our few-shot learning studies indicated that DINORET and BE DINORET outperform RETFound in terms of data-efficiency. This study highlights the potential of adapting natural domain vision models to retinal imaging using self-supervised learning and block expansion. BE DINORET offers robust performance without sacrificing previously acquired capabilities. Our findings suggest that these methods could enable healthcare institutions to develop tailored vision models for their patient populations, enhancing global healthcare inclusivity., Comment: J.Zoellin, C. Merk and M. Buob contributed equally as shared-first authors. D. Cabrera DeBuc, M. D. Becker and G. M. Somfai contributed equally as senior authors for this work

The BICEP3 and BICEP Array polarimeters are small-aperture refracting telescopes located at the South Pole designed to measure primordial gravitational wave signatures in the Cosmic Microwave Background (CMB) polarization, predicted by inflation. Constraining the inflationary signal requires not only excellent sensitivity, but also careful control of instrumental systematics. Both instruments use antenna-coupled orthogonally polarized detector pairs, and the polarized sky signal is reconstructed by taking the difference in each detector pair. As a result, the differential response between detectors within a pair becomes an important systematic effect we must control. Additionally, mapping the intensity and polarization response in regions away from the main beam can inform how sidelobe levels affect CMB measurements. Extensive calibration measurements are taken in situ every austral summer for control of instrumental systematics and instrument characterisation. In this work, we detail the set of beam calibration measurements that we conduct on the BICEP receivers, from deep measurements of main beam response to polarized beam response and sidelobe mapping. We discuss the impact of these measurements for instrumental systematics studies and design choices for future CMB receivers., Comment: 13 pages, 7 figures, 1 table, Proceedings paper SPIE 2024

Optical microscopy has long been the standard method for diagnosis in cytopathology. Whole slide scanners can image and digitize large sample areas automatically, but are slow, expensive and therefore not widely available. Clinical diagnosis of cytology specimens is especially challenging since these samples are both spread over large areas and thick, which requires 3D capture. Here, we introduce a new parallelized microscope for scanning thick specimens across extremely wide fields-of-view (54x72 mm^2) at 1.2 and 0.6 {\mu}m resolutions, accompanied by machine learning software to rapidly assess these 16 gigapixel scans. This Multi-Camera Array Scanner (MCAS) comprises 48 micro-cameras closely arranged to simultaneously image different areas. By capturing 624 megapixels per snapshot, the MCAS is significantly faster than most conventional whole slide scanners. We used this system to digitize entire cytology samples (scanning three entire slides in 3D in just several minutes) and demonstrate two machine learning techniques to assist pathologists: first, an adenocarcinoma detection model in lung specimens (0.73 recall); second, a slide-level classification model of lung smears (0.969 AUC).

Many science cases for wide-field time-domain surveys rely on accurate identification and characterization of the galaxies hosting transient and variable objects. In the era of the Legacy Survey of Space and Time (LSST) at the Vera C. Rubin Observatory the number of known transient and variable sources will grow by orders of magnitude, and many of these sources will be blended with their host galaxies and neighboring galaxies. A diverse range of applications - including the classification of nuclear and non-nuclear sources, identification of potential host galaxies, extraction of host galaxy SEDs without requiring a transient-free reference image, and combined analysis of photometry from multiple surveys - will benefit from a flexible framework to model time-domain imaging of transients. We describe a time-domain extension of the Scarlet2 scene modeling code for multi-epoch, multi-band, and multi-resolution imaging data to extract simultaneous transient and host galaxy models. Scarlet2 leverages the benefits of data-driven priors on galaxy morphology, is fully GPU compatible, and can jointly model multi-resolution data from ground and space-based surveys. We demonstrate the method on simulated LSST-like supernova imaging, low-resolution Zwicky Transient Facility imaging of tidal disruption events, and Hyper Suprime Cam imaging of variable AGN out to z = 4 in the COSMOS fields. We show that Scarlet2 models provide accurate transient and host galaxy models as well as accurate measurement of host-transient spatial offsets, and demonstrate future applications to the search for 'wandering' massive black holes., Comment: Submitted to Astronomy and Computing. 16 pages, 11 figures. Feedback welcome!

Myoelectric prosthetic hands are typically controlled to move between discrete positions and do not provide sensory feedback to the user. In this work, we present and evaluate a closed-loop, continuous myoelectric prosthetic hand controller, that can continuously control the position of multiple degrees of freedom of a prosthesis while rendering proprioceptive feedback to the user via a haptic feedback armband. Twenty-eight participants without and ten participants with limb difference were recruited to holistically evaluate the physical and psychological effects of the controller via isolated control and sensory tasks, dexterity assessments, embodiment and task load questionnaires, and post-study interviews. The combination of proprioceptive feedback and continuous control enabled accurate positioning, to within 10% mean absolute motor position error, and grasp-force modulation, to within 20% mean absolute motor force error, and restored blindfolded object identification ability to open-loop discrete controller levels. Dexterity assessment and embodiment questionnaire results revealed no significant physical performance or psychological embodiment differences between control types, with the exception of perceived sensation, which was significantly higher (p < 0.001) for closed-loop controllers. Key differences between participants with and without upper limb difference were identified, including in perceived body completeness and frustration, which can inform future prosthesis development and rehabilitation., Comment: 17 pages, 5 figures, 1 table. Submitted to Scientific Reports

Generative AI (GAI) holds great potential to improve software engineering productivity, but its untrustworthy outputs, particularly in code synthesis, pose significant challenges. The need for extensive verification and validation (V&V) of GAI-generated artifacts may undermine the potential productivity gains. This paper proposes a way of mitigating these risks by exploiting GAI's ability to generate multiple versions of code and tests to facilitate comparative analysis across versions. Rather than relying on the quality of a single test or code module, this "differential GAI" (D-GAI) approach promotes more reliable quality evaluation through version diversity. We introduce the Large-Scale Software Observatorium (LASSO), a platform that supports D-GAI by executing and analyzing large sets of code versions and tests. We discuss how LASSO enables rigorous evaluation of GAI-generated artifacts and propose its application in both software development and GAI research., Comment: This work has been accepted for publication in an upcoming issue of IEEE Software. This work has been submitted to the IEEE for possible publication

This paper presents experiments for embedded cooperative distributed model predictive control applied to a team of hovercraft floating on an air hockey table. The hovercraft collectively solve a centralized optimal control problem in each sampling step via a stabilizing decentralized real-time iteration scheme using the alternating direction method of multipliers. The efficient implementation does not require a central coordinator, executes onboard the hovercraft, and facilitates sampling intervals in the millisecond range. The formation control experiments showcase the flexibility of the approach on scenarios with point-to-point transitions, trajectory tracking, collision avoidance, and moving obstacles.

Archean atmospheric evolution is the transition from an abiological atmosphere, to an atmosphere for which the composition and therefore climate is highly altered by life. We review the key processes and transitions in this evolution., Comment: 16 pages, 1 figure. Accepted for publication as: Colin Goldblatt, Jake K. Eager-Nash, and Julia E. Horne (in press) "Evolution of the Archean Atmosphere", in: "The Archean Earth" (ed.: Martin Homan, Paul Mason, Richard Ernst, Timothy Lyons, Christoph Heubeck, Dominic Papineau, Eva Stueeken, Rajat Mazumder, Alexander Webb, Wladyslaw Altermann), Elsevier

A multitude of JWST studies reveal a surprising over-abundance of over-massive accreting super-massive blackholes (SMBHs) -- leading to a deepening tension between theory and observation in the first billion years of cosmic time. Across X-ray to infrared wavelengths, models built off of pre-JWST predictions fail to easily reproduce observed AGN signatures (or lack thereof), driving uncertainty around the true nature of these sources. Using a sample of JWST AGN identified via their broadened Halpha emission and covered by the deepest X-ray surveys, we find neither any measurable X-ray emission nor any detection of high-ionization emission lines frequently associated with accreting SMBHs. We propose that these sources are accreting at or beyond the Eddington limit, which reduces the need for efficient production of heavy SMBH seeds at cosmic dawn. Using a theoretical model of super-Eddington accretion, we can produce the observed relative dearth of both X-ray and ultraviolet emission, as well as the high Balmer decrements, without the need for significant dust attenuation. This work indicates that super-Eddington accretion is easily achieved through-out the early Universe, and further study is required to determine what environments are required to trigger this mode of black hole growth., Comment: Submitted

In this survey paper, I describe some aspects of the dynamics and the spectral theory of sub-Riemannian3D contact manifolds. We use Toeplitz quantization of the characteristic coneas introduced by Louis Boutet de Monvel and Victor Guillemin. We also discuss trace formulae following our work as well as the Duistermaat-Guillemin trace formula., Comment: dedicated to Victor, teacher and friend

Pull voting is a random process in which vertices of a connected graph have initial opinions chosen from a set of $k$ distinct opinions, and at each step a random vertex alters its opinion to that of a randomly chosen neighbour. If the system reaches a state where each vertex holds the same opinion, then this opinion will persist forthwith. In general the opinions are regarded as incommensurate, whereas in this paper we consider a type of pull voting suitable for integer opinions such as $\{1,2,\ldots,k\}$ which can be compared on a linear scale; for example, 1 ('disagree strongly'), 2 ('disagree'), $\ldots,$ 5 ('agree strongly'). On observing the opinion of a random neighbour, a vertex updates its opinion by a discrete change towards the value of the neighbour's opinion, if different. Discrete incremental voting is a pull voting process which mimics this behaviour. At each step a random vertex alters its opinion towards that of a randomly chosen neighbour; increasing its opinion by $+1$ if the opinion of the chosen neighbour is larger, or decreasing its opinion by $-1$, if the opinion of the neighbour is smaller. If initially there are only two adjacent integer opinions, for example $\{0,1\}$, incremental voting coincides with pull voting, but if initially there are more than two opinions this is not the case. For an $n$-vertex graph $G=(V,E)$, let $\lambda$ be the absolute second eigenvalue of the transition matrix $P$ of a simple random walk on $G$. Let the initial opinions of the vertices be chosen from $\{1,2,\ldots,k\}$. Let $c=\sum_{v \in V} \pi_v X_v$, where $X_v$ is the initial opinion of vertex $v$, and $\pi_v$ is the stationary distribution of the vertex. Then provided $\lambda k=o(1)$ and $k=o(n/\log n)$, with high probability the final opinion is the initial weighted average $c$ suitably rounded to $\lfloor c \rfloor$ or $\lceil c\rceil$., Comment: arXiv admin note: text overlap with arXiv:2305.15632

We report a combined experimental (C-AFM and SThM) and theoretical (DFT) study of the thermoelectric properties of molecular junctions made of self-assembled monolayers on Au of thiolated benzothieno-benzothiophene (BTBT) and alkylated BTBT derivatives (C8-BTBT-C8). We measure the thermal conductance per molecule at 15 pW/K and 8.8 pW/K, respectively, among the lowest values for molecular junctions so far reported (10-50 pW/K). The lower thermal conductance for C8-BTBT-C8 is consistent with two interfacial thermal resistances introduced by the alkyl chains, which reduce the phononic thermal transport in the molecular junction. The Seebeck coefficients are 36 {\mu}V/K and 245 {\mu}V/K, respectively, the latter due to the weak coupling of the core BTBT with the electrodes. We deduce a thermoelectric figure of merit ZT up to ca. 1E-4 for the BTBT molecular junctions at 300K, on a par with the values reported for archetype molecular junctions (olygo(phenylene ethynylene) derivatives)., Comment: Full paper and supporting information

Deviations of the cosmic microwave background (CMB) energy spectrum from a perfect blackbody uniquely probe a wide range of physics, ranging from fundamental physics in the primordial Universe ($\mu$-distortion) to late-time baryonic feedback processes (y-distortion). While the y-distortion can be detected with a moderate increase in sensitivity over that of COBE/FIRAS, the $\Lambda$CDM-predicted $\mu$-distortion is roughly two orders of magnitude smaller and requires substantial improvements, with foregrounds presenting a serious obstacle. Within the standard model, the dominant contribution to $\mu$ arises from energy injected via Silk damping, yielding sensitivity to the primordial power spectrum at wavenumbers $k \approx 1-10^{4}$ Mpc$^{-1}$. Here, we present a new instrument concept, SPECTER, with the goal of robustly detecting $\mu$. The instrument technology is similar to that of LiteBIRD, but with an absolute temperature calibration system. Using a Fisher approach, we optimize the instrument's configuration to target $\mu$ while robustly marginalizing over foreground contaminants. Unlike Fourier-transform-spectrometer-based designs, the specific bands and their individual sensitivities can be independently set in this instrument, allowing significant flexibility. We forecast SPECTER to observe the $\Lambda$CDM-predicted $\mu$-distortion at $\approx 5\sigma$ (10$\sigma$) assuming an observation time of 1 (4) year(s) (corresponding to mission duration of 2 (8) years), after foreground marginalization. Our optimized configuration includes 16 bands spanning 1-2000 GHz with degree-scale angular resolution at 150 GHz and 1046 total detectors. SPECTER will additionally measure the y-distortion at sub-percent precision and its relativistic correction at percent-level precision, yielding tight constraints on the total thermal energy and mean temperature of ionized gas., Comment: 26 pages, 12 figures

We present in this paper a novel approach for 3D/2D intraoperative registration during neurosurgery via cross-modal inverse neural rendering. Our approach separates implicit neural representation into two components, handling anatomical structure preoperatively and appearance intraoperatively. This disentanglement is achieved by controlling a Neural Radiance Field's appearance with a multi-style hypernetwork. Once trained, the implicit neural representation serves as a differentiable rendering engine, which can be used to estimate the surgical camera pose by minimizing the dissimilarity between its rendered images and the target intraoperative image. We tested our method on retrospective patients' data from clinical cases, showing that our method outperforms state-of-the-art while meeting current clinical standards for registration. Code and additional resources can be found at https://maxfehrentz.github.io/style-ngp/., Comment: Accepted at MICCAI 2024

Abstract Objective In Genetic Absence Epilepsy Rats From Strasbourg ( GAERS s), epileptogenesis takes place during brain maturation and correlates with increased mRNA expression of D3 dopamine receptors (D3R). Whether these alterations are the consequence of seizure repetition or contribute to the development of epilepsy remains to be clarified. Here, we addressed the involvement of the dopaminergic system in epilepsy onset in GAERS s. Methods Experiments were performed using rats at different stages of brain maturation from three strains according to their increasing propensity to develop absence seizures: nonepileptic control rats ( NEC s), Wistar Hannover rats, and GAERS s. Changes in dopaminergic neurotransmission were investigated using different behavioral and neurochemical approaches: autoradiography of D3R and dopamine transporter, single photon emission computed tomographic imaging, acute and chronic drug effects on seizure recordings (dopaminergic agonists and antagonists), quinpirole-induced yawns and dopamine synaptosomal uptake, microdialysis, brain tissue monoamines, and brain-derived neurotrophic factor quantification. Results Autoradiography revealed an increased expression of D3R in 14-day-old GAERS s, before absence seizure onset, that persists in adulthood, as compared to age-matched NEC s. This was confirmed by increased yawns, a marker of D3R activity, and increased seizures when animals were injected with quinpirole at low doses to activate D3R. We also observed a concomitant increase in the expression and activity of the dopamine transporter in GAERS s before seizure onset, consistent with both lowered dopamine basal level and increased phasic responses. Significance Our data show that the dopaminergic system is persistently altered in GAERS s, which may contribute not only to behavioral comorbidities but also as an etiopathogenic factor in the development of epilepsy. The data suggest that an imbalanced dopaminergic tone may contribute to absence epilepsy development and seizure onset, as its reversion by a chronic treatment with a dopamine stabilizer significantly suppressed epileptogenesis. Our data suggest a potential new target for antiepileptic therapies and/or improvement of quality of life of epileptic patients.

The Mittelman-di Cicco-Walker (MDW) H$\alpha$ Sky Survey is an autonomously-operated and ongoing all-sky imaging survey in the narrowband H$\alpha$ wavelength. The survey was founded by amateur astronomers, and is presented here in its first stage of refinement for rigorous scientific use. Each field is exposed through an H$\alpha$ filter with a 3nm bandwidth for a total of four hours, with a pixel scale of 3.2 arcsec. Here, we introduce the first Data Release of the MDW H$\alpha$ Survey (Data Release 0, or DR0), spanning 238 fields in the region of Orion (~3100 deg$^2$). DR0 includes: calibrated mean fields, star-removed mean fields, a point source catalog matched to Data Release 1 of the Panoramic Survey Telescope and Rapid Response System (Pan-STARRS1) and the INT Galactic Plane Survey (IGAPS), and mosaics.

We study the symmetries of the Liouville superoperator of one dimensional parametric oscillators, especially the so-called squeeze-driven Kerr oscillator, and discover a remarkable quasi-spin symmetry $su(2)$ at integer values of the ratio $\eta =\omega /K$ of the detuning parameter $\omega$ to the Kerr coefficient $K$, which reflects the symmetry previously found for the Hamiltonian operator. We find that the Liouvillian of an $su(2)$ representation $\left\vert j,m_{j}\right\rangle$ has a characteristic double-ellipsoidal structure, and calculate the relaxation time $T_{X}$ for this structure. We then study the phase transitions of the Liouvillian which occur as a function of the parameters $\xi =\varepsilon _{2}/K$ and $\eta=\omega /K$. Finally, we study the temperature dependence of the spectrum of eigenvalues of the Liouvillian. Our findings may have applications in the generation and stabilization of states of interest in quantum computing., Comment: 36 pages, 23 figures, to appear in J. Phys. A: Math. Theor

The resonant conversion of cosmic microwave background (CMB) photons into axions within large-scale structure induces an anisotropic spectral distortion in CMB temperature maps. Applying state-of-the-art foreground cleaning techniques to $\textit{Planck}$ CMB observations, we construct maps of axion-induced "patchy screening" of the CMB. We cross-correlate these maps with data from the $\textit{unWISE}$ galaxy survey and find no evidence of axions. We constrain the axion-photon coupling, $g_{a\gamma\gamma} \lesssim 2 \times 10^{-12}~{\rm GeV}^{-1}$, at the 95% confidence level for axion masses in the range $10^{-13}~{\rm eV} \lesssim m_a \lesssim 10^{-12}~{\rm eV}$. These constraints are competitive with the tightest astrophysical axion limits in this mass range and are inferred from robust population-level statistics, which makes them complementary to existing searches that rely on modeling of individual systems., Comment: 5+15 pages; 3+15 figures

Over the Nullarbor Plain in South Australia, the Desert Fireball Network detected a fireball on the night of 1 June 2019 (7:30 pm local time), and six weeks later recovered a single meteorite (42 g) named Arpu Kuilpu. This meteorite was then distributed to a consortium of collaborating institutions to be measured and analyzed by a number of methodologies including: SEM-EDS, EPMA, ICP-MS, gamma-ray spectrometry, ideal gas pycnometry, magnetic susceptibility measurement, {\mu}CT, optical microscopy, and accelerator and noble gas mass spectrometry techniques. These analyses revealed that Arpu Kuilpu is an unbrecciated H5 ordinary chondrite, with minimal weathering (W0-1) and minimal shock (S2). The olivine and pyroxene mineral compositions (in mol%) are Fa: 19.2 +- 0.2, and Fs: 16.8 +- 0.2, further supporting the H5 type and class. The measured oxygen isotopes are also consistent with an H chondrite ({\delta}17O = 2.904 +- 0.177; {\delta}18O = 4.163 +- 0.336; {\Delta}17O = 0.740 +- 0.002). Ideal gas pycnometry measured bulk and grain densities of 3.66 +- 0.02 and 3.77 +- 0.02 g cm-3, respectively, yielding a porosity of 3.0 % +- 0.7. The magnetic susceptibility of this meteorite is log X = 5.16 +- 0.08. The most recent impact-related heating event experienced by Arpu Kuilpu was measured by 40Ar/39Ar chronology to be 4467 +- 16 Ma, while the cosmic ray exposure age is estimated to be between 6-8 Ma. The noble gas isotopes, radionuclides, and fireball observations all indicate that Arpu Kuilpu's meteoroid was quite small (maximum radius of 10 cm, though more likely between 1-5 cm). Although this meteorite is a rather ordinary ordinary chondrite, its prior orbit resembled that of a Jupiter Family Comet (JFC) further lending support to the assertion that many cm- to m-sized objects on JFC orbits are asteroidal rather than cometary in origin.

Wildfires pose a significant natural disaster risk to populations and contribute to accelerated climate change. As wildfires are also affected by climate change, extreme wildfires are becoming increasingly frequent. Although they occur less frequently globally than those sparked by human activities, lightning-ignited wildfires play a substantial role in carbon emissions and account for the majority of burned areas in certain regions. While existing computational models, especially those based on machine learning, aim to predict lightning-ignited wildfires, they are typically tailored to specific regions with unique characteristics, limiting their global applicability. In this study, we present machine learning models designed to characterize and predict lightning-ignited wildfires on a global scale. Our approach involves classifying lightning-ignited versus anthropogenic wildfires, and estimating with high accuracy the probability of lightning to ignite a fire based on a wide spectrum of factors such as meteorological conditions and vegetation. Utilizing these models, we analyze seasonal and spatial trends in lightning-ignited wildfires shedding light on the impact of climate change on this phenomenon. We analyze the influence of various features on the models using eXplainable Artificial Intelligence (XAI) frameworks. Our findings highlight significant global differences between anthropogenic and lightning-ignited wildfires. Moreover, we demonstrate that, even over a short time span of less than a decade, climate changes have steadily increased the global risk of lightning-ignited wildfires. This distinction underscores the imperative need for dedicated predictive models and fire weather indices tailored specifically to each type of wildfire.

Mental health concerns are prevalent among college students, highlighting the need for effective interventions that promote self-awareness and holistic well-being. MindScape pioneers a novel approach to AI-powered journaling by integrating passively collected behavioral patterns such as conversational engagement, sleep, and location with Large Language Models (LLMs). This integration creates a highly personalized and context-aware journaling experience, enhancing self-awareness and well-being by embedding behavioral intelligence into AI. We present an 8-week exploratory study with 20 college students, demonstrating the MindScape app's efficacy in enhancing positive affect (7%), reducing negative affect (11%), loneliness (6%), and anxiety and depression, with a significant week-over-week decrease in PHQ-4 scores (-0.25 coefficient), alongside improvements in mindfulness (7%) and self-reflection (6%). The study highlights the advantages of contextual AI journaling, with participants particularly appreciating the tailored prompts and insights provided by the MindScape app. Our analysis also includes a comparison of responses to AI-driven contextual versus generic prompts, participant feedback insights, and proposed strategies for leveraging contextual AI journaling to improve well-being on college campuses. By showcasing the potential of contextual AI journaling to support mental health, we provide a foundation for further investigation into the effects of contextual AI journaling on mental health and well-being., Comment: arXiv admin note: text overlap with arXiv:2404.00487

The entanglement asymmetry is an observable independent tool to investigate the relaxation of quantum many body systems through the restoration of an initially broken symmetry of the dynamics. In this paper we use this to investigate the effects of interactions on quantum relaxation in a paradigmatic integrable model. Specifically, we study the dynamical restoration of the $U(1)$ symmetry corresponding to rotations about the $z$-axis in the XXZ model quenched from a tilted ferromagnetic state. We find two distinct patterns of behaviour depending upon the interaction regime of the model. In the gapless regime, at roots of unity, we find that the symmetry restoration is predominantly carried out by bound states of spinons of maximal length. The velocity of these bound states is suppressed as the anisotropy is decreased towards the isotropic point leading to slower symmetry restoration. By varying the initial tilt angle, one sees that symmetry restoration is slower for an initally smaller tilt angle, signifying the presence of the quantum Mpemba effect. In the gapped regime however, spin transport for non maximally tilted states, is dominated by smaller bound states with longer bound states becoming frozen. This leads to a much longer time scales for restoration compared to the gapless regime. In addition, the quantum Mpemba effect is absent in the gapped regime., Comment: 19+5 pages, 5 figures

We explore how III-V semiconductor microring resonators can efficiently generate photon pairs and squeezed vacuum states via spontaneous parametric down-conversion by utilizing their built-in quasi phase matching and modal dispersion. We present an analytic expression for the biphoton wave function of photon pairs generated by weak pump pulses, and characterize the squeezed states that result under stronger pumping conditions. Our model includes loss, and captures the statistics of the scattered photons. A detailed sample calculation shows that for low pump powers conversion efficiencies of 10$^{-5}$, corresponding to a rate of 39 MHz for a pump power of 1 $\mu$W, are attainable for rudimentary structures such as a simple microring coupled to a waveguide, in both the continuous wave and pulsed excitation regimes. Our results suggest that high levels of squeezing and pump depletion are attainable, possibly leading to the deterministic generation of non-Gaussian states, Comment: 17 pages, 9 figures

Robust atomic resolution structural characterization of point defects in 3D is a longstanding challenge for electron microscopy. Here, we evaluate multislice electron ptychography as a tool to carry out 3D atomic resolution characterization of point defects in silicon carbide as a model. Through multislice electron scattering simulations, subsequent ptychographic reconstructions, and data analysis, we show that intrinsic defects such as vacancies and substitutions beyond transition metals can be detected with a depth precision of approximately 0.1 nm with realistic sample and microscope conditions. Furthermore, the dependence of contrast at defect sites on electron energy and dose, as well as optimal acquisition parameters, are described. Overall, these results serve as a guidepost to experiments aiming to analyze point defects beyond extremely thin specimens or only heavy elements.

Ion implantation is widely used to dope semiconductors for electronic device fabrication, but techniques to quantify point defects and induced damage are limited. While several techniques can measure dopant concentration profiles with high accuracy, none allow for simultaneous atomic resolution structural analysis. Here, we use multislice electron ptychography to quantify the damage induced by erbium implantation in a wide band gap semiconductor 4H-SiC over a 1,000 nm\textsuperscript{3} volume region. This damage extends further into the sample than expected from implantation simulations that do not consider crystallography. Further, the technique's sensitivity to dopants and vacancies is evaluated as a function of damage. As each reconstructed analysis volume contains approximately 10$^5$ atoms, sensitivity of 10\textsuperscript{18} cm\textsuperscript{-3} (in the order of 10 ppm) is demonstrated in the implantation tail region. After point defect identification, the local distortions surrounding \ch{Er_{Si}} and \ch{v_{Si}} defects are quantified. These results underscore the power of multislice electron ptychography to enable the investigation of point defects as a tool to guide the fabrication of future electronic devices.

In this paper we present a step-by-step approach to long-form text translation, drawing on established processes in translation studies. Instead of viewing machine translation as a single, monolithic task, we propose a framework that engages language models in a multi-turn interaction, encompassing pre-translation research, drafting, refining, and proofreading, resulting in progressively improved translations. Extensive automatic evaluations using Gemini 1.5 Pro across ten language pairs show that translating step-by-step yields large translation quality improvements over conventional zero-shot prompting approaches and earlier human-like baseline strategies, resulting in state-of-the-art results on WMT2024.

3C 264 is one of the few FRI radio galaxies with detected TeV emission. It is a low-luminosity AGN (LLAGN) and is generally associated with a radiatively inefficient accretion flow (RIAF). Earlier multiwavelength studies suggest that the X-ray emission originates from a jet. However, the possibility that the RIAF can significantly contribute to the X-rays cannot be ruled out. In particular, hard X-ray emission $\gtrsim$10 keV has never been detected, making it challenging to distinguish between X-ray models. Here we report a NuSTAR detection up to 25 keV from 3C 264. We also present subpixel deconvolved Chandra images to resolve jet emission down to ~0.2 arcsec from the center of the unresolved X-ray core. Together with a simultaneous Swift observation, we have constrained the dominant hard X-ray emission to be from its unresolved X-ray core, presumably in its quiescent state. We found evidence of a cutoff in the energy around 20 keV, indicating that at least some of the X-rays from the core can be attributed to the RIAF. The Comptonization model suggests an electron temperature of about 15 keV and an optical depth ranging between 4 and 7, following the universality of coronal properties of black hole accretion. The cutoff energy or electron temperature of 3C 264 is the lowest among those of other LLAGNs. The detected hard X-ray emission is at least an order of magnitude higher than that predicted by synchrotron self-Compton models introduced to explain $\gamma$-ray and TeV emission, suggesting that the synchrotron electrons might be accelerated to higher energies than previously thought., Comment: 19 pages, 6 figures, 2 tables, accepted for publication in ApJ, figure 3 is compressed to reduce file size

Defant found that the relationship between a sequence of (univariate) classical cumulants and the corresponding sequence of (univariate) free cumulants can be described combinatorially in terms of families of binary plane trees called troupes. Using a generalization of troupes that we call weighted troupes, we generalize this result to allow for multivariate cumulants. Our result also gives a combinatorial description of the corresponding Boolean cumulants. This allows us to answer a question of Defant regarding his troupe transform. We also provide explicit distributions whose cumulants correspond to some specific weighted troupes., Comment: 18 pages, 7 figures

In the NISQ era, where quantum information processing is hindered by the decoherence and dissipation of elementary quantum systems, developing new protocols to extend the lifetime of quantum states is of considerable practical and theoretical importance. A prominent method, called dynamical decoupling, uses a carefully designed sequence of pulses applied to a quantum system, such as a qudit (a d-level quantum system), to suppress the coupling Hamiltonian between the system and its environment, thereby mitigating dissipation. While dynamical decoupling of qubit systems has been widely studied, the decoupling of qudit systems has been far less explored and often involves complex sequences and operations. In this work, we design efficient decoupling sequences composed solely of SU(2) rotations and based on tetrahedral, octahedral, and icosahedral point groups, which we call Platonic sequences. We use a generalization of the Majorana representation for Hamiltonians to develop a simple framework that establishes the decoupling properties of each Platonic sequence and show its efficiency on many examples. These sequences are universal in their ability to cancel any type of interaction with the environment for single qudits with up to 6 levels, and they are capable of decoupling up to 5-body interactions in an ensemble of interacting qubits with only global pulses, provided that the interaction Hamiltonian has no isotropic component, with the exception of the global identity. We also discuss their inherent robustness to finite pulse duration and a wide range of pulse errors, as well as their potential application as building blocks for dynamically corrected gates., Comment: 23 pages, 8 figures

Large language models (LLM) have prioritized expanding the context window from which models can incorporate more information. However, training models to handle long contexts presents significant challenges. These include the scarcity of high-quality natural long-context data, the potential for performance degradation on short-context tasks, and the reduced training efficiency associated with attention mechanisms. In this paper, we introduce Untie the Knots (\textbf{UtK}), a novel data augmentation strategy employed during the continue pre-training phase, designed to efficiently enable LLMs to gain long-context capabilities without the need to modify the existing data mixture. In particular, we chunk the documents, shuffle the chunks, and create a complex and knotted structure of long texts; LLMs are then trained to untie these knots and identify relevant segments within seemingly chaotic token sequences. This approach greatly improves the model's performance by accurately attending to relevant information in long context and the training efficiency is also largely increased. We conduct extensive experiments on models with 7B and 72B parameters, trained on 20 billion tokens, demonstrating that UtK achieves 75\% and 84.5\% accurracy on RULER at 128K context length, significantly outperforming other long context strategies. The trained models will open-source for further research.

Using particle data from the ELFIN satellites, we present a statistical study of 284 proton isotropy boundary events on the nightside magnetosphere, characterizing their occurrence and distribution in local time, latitude (L-shell), energy, and precipitating energy flux, as a function of geomagnetic activity. For a given charged particle species and energy, its isotropy boundary (IB) is the magnetic latitude poleward of which persistently isotropic pitch-angle distributions ($J_{prec}/J_{perp}\sim 1$) are first observed to occur. This isotropization is interpreted as resulting from magnetic field-line curvature (FLC) scattering in the equatorial magnetosphere. We find that proton IBs are observed under all observed activity levels, spanning 16 to 05 MLT with $\sim$100% occurrence between 19 and 03 MLT, trending toward 60% at dawn/dusk. These results are also compared with electron IB properties observed using ELFIN, where we find similar trends across local time and activity, with the onset in $\geq$50 keV proton IB occurring on average 2 L-shells lower, and providing between 3 and 10 times as much precipitating power. Proton IBs typically span $64^\circ$-$66^\circ$ in magnetic latitude (5-6 in L-shell), corresponding to the outer edge of the ring current, tending toward lower IGRF latitudes as geomagnetic activity increases. The IBs were found to commonly occur 0.3-2.1 Re beyond the plasmapause. Proton IBs typically span $<$50 keV to $\sim$1 MeV in energy, maximizing near 22 MLT, and decreasing to a typical upper limit of 300-400 keV toward dawn and dusk, with peak observed isotropic energy increasing by $\sim$500 keV during active intervals. These results suggest that FLC in the vicinity of IBs can provide a substantial depletion mechanism for energetic protons, with the total nightside precipitating power from FLC-scattering found to be on the order of 100 MW, at times $\geq$10 GW.

In \cite{Ha86} Harer explicitly constructed a spine for the decorated Teichm\"uller space of orientable surfaces with at least one puncture and negative Euler characteristic. In this paper we point out some instances where his computation of the dimension of this spine is off by $1$ and give the correct dimension., Comment: 10 pages, 4 figures

Surface-based analysis of the cerebral cortex is ubiquitous in human neuroimaging with MRI. It is crucial for cortical registration, parcellation, and thickness estimation. Traditionally, these analyses require high-resolution, isotropic scans with good gray-white matter contrast, typically a 1mm T1-weighted scan. This excludes most clinical MRI scans, which are often anisotropic and lack the necessary T1 contrast. To enable large-scale neuroimaging studies using vast clinical data, we introduce recon-all-clinical, a novel method for cortical reconstruction, registration, parcellation, and thickness estimation in brain MRI scans of any resolution and contrast. Our approach employs a hybrid analysis method that combines a convolutional neural network (CNN) trained with domain randomization to predict signed distance functions (SDFs) and classical geometry processing for accurate surface placement while maintaining topological and geometric constraints. The method does not require retraining for different acquisitions, thus simplifying the analysis of heterogeneous clinical datasets. We tested recon-all-clinical on multiple datasets, including over 19,000 clinical scans. The method consistently produced precise cortical reconstructions and high parcellation accuracy across varied MRI contrasts and resolutions. Cortical thickness estimates are precise enough to capture aging effects independently of MRI contrast, although accuracy varies with slice thickness. Our method is publicly available at https://surfer.nmr.mgh.harvard.edu/fswiki/recon-all-clinical, enabling researchers to perform detailed cortical analysis on the huge amounts of already existing clinical MRI scans. This advancement may be particularly valuable for studying rare diseases and underrepresented populations where research-grade MRI data is scarce., Comment: 16 pages in the manuscript with 11 page supplementary material

We present a joint analysis of the CMB lensing power spectra measured from the Data Release 6 of the Atacama Cosmology Telescope and Planck PR4, cross-correlations between the ACT and Planck lensing reconstruction and galaxy clustering from unWISE, and the unWISE clustering auto-spectrum. We obtain 1.5% constraints on the matter density fluctuations at late times parametrised by the best constrained parameter combination $S_8^{\rm 3x2pt}\equiv\sigma_8 (\Omega_m/0.3)^{0.4}=0.815\pm0.012$. The commonly used $S_8\equiv\sigma_8 (\Omega_m/0.3)^{0.5}$ parameter is constrained to $S_8=0.816\pm0.015$. In combination with baryon acoustic oscillation (BAO) measurements we find $\sigma_8=0.815\pm 0.012$. We also present sound-horizon-independent estimates of the present day Hubble rate of $H_0=66.4^{+3.2}_{-3.7} \,\mathrm{km}\,\mathrm{s}^{-1}\mathrm{Mpc}^{-1}$ from our large scale structure data alone and $H_0=64.3^{+2.1}_{-2.4}\,\mathrm{km}\,\mathrm{s}^{-1}\mathrm{Mpc}^{-1}$ in combination with uncalibrated supernovae from Pantheon+. Using parametric estimates of the evolution of matter density fluctuations, we place constraints on cosmic structure in a range of high redshifts typically inaccessible with cross-correlation analyses. Combining lensing cross- and auto-correlations, we derive a 3.3% constraint on the integrated matter density fluctuations above $z=2.4$, one of the tightest constraints in this redshift range and fully consistent with a $\Lambda$CDM model fit to the primary CMB from Planck. Combining with primary CMB observations and using the extended low redshift coverage of these combined data sets we derive constraints on a variety of extensions to the $\Lambda$CDM model including massive neutrinos, spatial curvature, and dark energy. We find in flat $\Lambda$CDM $\sum m_\nu<0.12$ eV at 95% confidence using the LSS data, BAO measurements from SDSS and primary CMB observations., Comment: 30 pages, 15 figures, to be submitted to PRD, comments welcome