51. Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress
- Author
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Hazegh, Kelsey, Fang, Fang, Bravo, Marjorie D, Tran, Johnson Q, Muench, Marcus O, Jackman, Rachael P, Roubinian, Nareg, Bertolone, Lorenzo, DʼAlessandro, Angelo, Dumont, Larry, Page, Grier P, and Kanias, Tamir
- Subjects
Medical Biochemistry and Metabolomics ,Biomedical and Clinical Sciences ,Hematology ,Nutrition ,Prevention ,Obesity ,Clinical Trials and Supportive Activities ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Metabolic and endocrine ,Cardiovascular ,Good Health and Well Being ,Adult ,Animals ,Blood Donors ,Blood Preservation ,Body Mass Index ,Cold Temperature ,Erythrocyte Membrane ,Erythrocyte Transfusion ,Erythrocytes ,Female ,Ferritins ,Hematologic Tests ,Hemolysis ,Humans ,Leukocyte Reduction Procedures ,Male ,Membrane Lipids ,Metabolome ,Mice ,Mice ,Inbred NOD ,Nitric Oxide ,Osmotic Pressure ,Oxidative Stress ,blood donors ,BMI ,hemolysis ,obesity ,red blood cells ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Immunology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
BackgroundObesity is a global pandemic characterized by multiple comorbidities, including cardiovascular and metabolic diseases. The aim of this study was to define the associations between blood donor body mass index (BMI) and RBC measurements of metabolic stress and hemolysis.Study design and methodsThe associations between donor BMI (
- Published
- 2021