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638 results on '"Cohen, Jordana"'

52. Cardiac Biomarkers and Risk of Mortality in CKD (the CRIC Study)

Author

Appel, Lawrence J., Feldman, Harold I., Go, Alan S., He, Jiang, Lash, James P., Rao, Panduranga S., Rahman, Mahboob, Townsend, Raymond R., Wang, Ke, Zelnick, Leila R., Anderson, Amanda, Cohen, Jordana, Dobre, Mirela, Deo, Rajat, Feldman, Harold, Go, Alan, Hsu, Jesse, Jaar, Bernard, Kansal, Mayank, Shlipak, Michael, Soliman, Elsayed, Rao, Panduranga, Weir, Matt, and Bansal, Nisha

Published
2020
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53. Erythropoiesis-Stimulating Agents and the Risk of Vision-Threatening Diabetic Retinopathy.

Author

Tsui, Jonathan C., Willett, Keirnan, Cohen, Jordana B., Yu, Yinxi, and VanderBeek, Brian L.

Subjects
DIABETIC retinopathy, VASCULAR endothelial growth factors, MACULAR edema, MEDICARE Part C
Abstract

Animal studies have suggested that Erythropoiesis-Stimulating Agents (ESAs) may increase vascular endothelial growth factor (VEGF)-related retinopathies, but this effect is unclear in humans. This study evaluates the risk of vision-threatening diabetic retinopathy (VTDR), defined as either diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR), in patients exposed to an ESA. Two analyses were performed. First, a retrospective matched-cohort study was designed using a de-identified commercial and Medicare Advantage medical claims database. The ESA cohort of non-proliferative diabetic retinopathy patients who were new users of an ESA from 2000 to 2022 was matched to controls up to a 3:1 ratio. Exclusion criteria included less than 2 years in the plan, history of VTDR or history of other retinopathy. Multivariable Cox proportional hazards regression with inverse proportional treatment weighting (IPTW) was used to assess the hazard of developing VTDR, DME, and PDR. The second analysis was a self-controlled case series (SCCS) evaluating the incidence rate ratios (IRR) of VTDR during 30-day periods before and after initiating an ESA. After inclusion of 1502 ESA-exposed patients compared with 2656 controls, IPTW-adjusted hazard ratios found the ESA cohort had an increased hazard of progressing to VTDR (HR = 3.0 95%CI:2.3–3.8;p <.001) and DME (HR = 3.4,95%CI:2.6–4.4,p <.001), but not PDR (HR = 1.0,95%CI:0.5–2.3,p =.95). Similar results were found within the SCCS which demonstrated higher IRRs for VTDR (IRRs = 1.09–1.18;p <.001) and DME (IRRs = 1.16–1.18;p <.001), but not increased IRRs in PDR (IRR = 0.92–0.97,p =.02–0.39). ESAs are associated with higher risks for VTDR and DME, but not PDR. Those studying ESAs as adjunctive therapy for DR should be cautious of possible unintended effects. [ABSTRACT FROM AUTHOR]

Published
2024
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54. The Impact of Health Care Algorithms on Racial and Ethnic Disparities: A Systematic Review.

Author

Siddique, Shazia Mehmood, Tipton, Kelley, Leas, Brian, Jepson, Christopher, Aysola, Jaya, Cohen, Jordana B., Flores, Emilia, Harhay, Michael O., Schmidt, Harald, Weissman, Gary E., Fricke, Julie, Treadwell, Jonathan R., and Mull, Nikhil K.

Subjects
RACIAL inequality, HEALTH services accessibility, HEALTH equity, DEMOGRAPHIC characteristics, MEDICAL care, DISCRIMINATION in medical care, ALLOCATION of organs, tissues, etc.
Abstract

Algorithms are used in health care to calculate organ function and predict patient risk or future outcomes, and, subsequently, for treatment decisions, further diagnostic procedures, or referral for further care. Inputs to algorithms and how they are calculated may result in racial or ethnic disparities in access to care, quality of care, and disparities in health outcomes. This paper systematically reviews studies that have evaluated the impact of algorithms on racial or ethnic disparities and what strategies have been used to mitigate such disparities. Background: There is increasing concern for the potential impact of health care algorithms on racial and ethnic disparities. Purpose: To examine the evidence on how health care algorithms and associated mitigation strategies affect racial and ethnic disparities. Data Sources: Several databases were searched for relevant studies published from 1 January 2011 to 30 September 2023. Study Selection: Using predefined criteria and dual review, studies were screened and selected to determine: 1) the effect of algorithms on racial and ethnic disparities in health and health care outcomes and 2) the effect of strategies or approaches to mitigate racial and ethnic bias in the development, validation, dissemination, and implementation of algorithms. Data Extraction: Outcomes of interest (that is, access to health care, quality of care, and health outcomes) were extracted with risk-of-bias assessment using the ROBINS-I (Risk Of Bias In Non-randomised Studies – of Interventions) tool and adapted CARE-CPM (Critical Appraisal for Racial and Ethnic Equity in Clinical Prediction Models) equity extension. Data Synthesis: Sixty-three studies (51 modeling, 4 retrospective, 2 prospective, 5 prepost studies, and 1 randomized controlled trial) were included. Heterogenous evidence on algorithms was found to: a) reduce disparities (for example, the revised kidney allocation system), b) perpetuate or exacerbate disparities (for example, severity-of-illness scores applied to critical care resource allocation), and/or c) have no statistically significant effect on select outcomes (for example, the HEART Pathway [history, electrocardiogram, age, risk factors, and troponin]). To mitigate disparities, 7 strategies were identified: removing an input variable, replacing a variable, adding race, adding a non–race-based variable, changing the racial and ethnic composition of the population used in model development, creating separate thresholds for subpopulations, and modifying algorithmic analytic techniques. Limitation: Results are mostly based on modeling studies and may be highly context-specific. Conclusion: Algorithms can mitigate, perpetuate, and exacerbate racial and ethnic disparities, regardless of the explicit use of race and ethnicity, but evidence is heterogeneous. Intentionality and implementation of the algorithm can impact the effect on disparities, and there may be tradeoffs in outcomes. Primary Funding Source: Agency for Healthcare Quality and Research. [ABSTRACT FROM AUTHOR]

Published
2024
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56. Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction: Detailed Phenotypes, Prognosis, and Response to Spironolactone

Author

Cohen, Jordana B., Schrauben, Sarah J., Zhao, Lei, Basso, Michael D., Cvijic, Mary Ellen, Li, Zhuyin, Yarde, Melissa, Wang, Zhaoqing, Bhattacharya, Priyanka T., Chirinos, Diana A., Prenner, Stuart, Zamani, Payman, Seiffert, Dietmar A., Car, Bruce D., Gordon, David A., Margulies, Kenneth, Cappola, Thomas, and Chirinos, Julio A.

Published
2020
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59. Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications

Author

Kandzari, David E., primary, Townsend, Raymond R., additional, Kario, Kazuomi, additional, Mahfoud, Felix, additional, Weber, Michael A., additional, Schmieder, Roland E., additional, Pocock, Stuart, additional, Tsioufis, Konstantinos, additional, Konstantinidis, Dimitrios, additional, Choi, James, additional, East, Cara, additional, Lauder, Lucas, additional, Cohen, Debbie L., additional, Kobayashi, Taisei, additional, Schmid, Axel, additional, Lee, David P., additional, Ma, Adrian, additional, Weil, Joachim, additional, Agdirlioglu, Tolga, additional, Schlaich, Markus P., additional, Shetty, Sharad, additional, Devireddy, Chandan M., additional, Lea, Janice, additional, Aoki, Jiro, additional, Sharp, Andrew S.P., additional, Anderson, Richard, additional, Fahy, Martin, additional, DeBruin, Vanessa, additional, Brar, Sandeep, additional, Böhm, Michael, additional, Wang, Yale, additional, Jay, Desmond, additional, McLaurin, Brent, additional, Lomboy, Carl, additional, Allaqaband, Suhail, additional, Jan, Fuad, additional, Gummadi, Bharat, additional, Litt, Marc, additional, Garcia, Fidel, additional, Singh, Jasvindar, additional, Brown, Angela, additional, Paul, Ashley, additional, Sharp, Andrew, additional, Coulson, James, additional, Nanjundappa, Aravinda, additional, Thakker, Ganpat, additional, Campbell, James, additional, Honton, Benjamin, additional, Farah, Bruno, additional, Patel, Manesh, additional, Gutierrez, Antonio, additional, Tyson, Crystal, additional, Svetkey, Laura, additional, Fudim, Marat, additional, Pagidipati, Neha, additional, Jones, Schuyler, additional, Vemulapalli, Sreekanth, additional, Devireddy, Chandan, additional, Kulshreshtha, Ambar, additional, Wells, Bryan, additional, Batson, Bryan, additional, Wilkins, Robert, additional, Sharif, Faisal, additional, Khair, Abdullahi Mohamed, additional, Pallippattu, Abhishek Wilson, additional, Alhmoudi, Aishah Matar, additional, Gaffney, Brian, additional, Cawley, Christian, additional, Gorry, Colin, additional, Hamed, Hanan, additional, Carron, Jennifer, additional, Birrane, John, additional, Rosseel, Liesbeth, additional, Lunardi, Mattia, additional, Cronin, Michael, additional, McKittrick, Myles, additional, Almagal, Naeif, additional, Khalid, Noman, additional, Shehahd, Qussai, additional, Shahzad, Shirjeel, additional, Fezzi, Simone, additional, Tyulkin, Stanislav, additional, Bel, Xavier Armario, additional, Jolly, Sanjit, additional, Yip, Gordon, additional, Schwalm, Jon-David, additional, Tsang, Michael, additional, Mehta, Shamir, additional, Lurz, Philipp C., additional, Binner, Christian, additional, Obradovic, Danilo, additional, Fahr, Florian, additional, Richter, Ines, additional, Rotta detto Loria, Johannes, additional, Fengler, Karl, additional, Rommel, Karl-Philipp, additional, Cuartas, Mateo Marin, additional, Lerche, Matthias, additional, Hartung, Philipp, additional, Münch, Phillip, additional, Höllriegel, Robert, additional, John, Silke, additional, Otsuji, Satoru, additional, Kusumoto, Hirofumi, additional, Tamaru, Hiroto, additional, Ishibuchi, Kasumi, additional, Hasegawa, Katsuyuki, additional, Sugimoto, Ken, additional, Kakishita, Mikio, additional, Ishii, Rui, additional, Takiuchi, Shin, additional, Yasuda, Shingo, additional, Nakabayashi, Sho, additional, Yamamoto, Wataru, additional, Higashino, Yorihiko, additional, Shimatani, Yuji, additional, Taniguchi, Yusuke, additional, Kasiakogias, Alexandros, additional, Konstantinidis, Dimitris, additional, Andrikou, Eirini, additional, Konstantinou, Konstantinos, additional, Dimitriadis, Kyriakos, additional, Kalos, Theodoros, additional, Cohen, Debbie, additional, Rene, Garvey, additional, Cohen, Jordana, additional, Bonanni, Maria, additional, Denker, Matthew, additional, Wickramisinghe, Rasi, additional, Wilensky, Robert, additional, Kobayashi, Tai, additional, Anjan, Venkatesh, additional, Huan, Yonghong, additional, Haught, Walter Herbert, additional, Krasnow, Joshua, additional, Vasquez, Alejandro, additional, Gessler, Carl, additional, Roth, Christopher, additional, Drenning, David, additional, Velasquez, Enrique, additional, Soliman, George, additional, Murphy, James, additional, Jain, Kaushik, additional, Butler, Michael, additional, Kanitkar, Mihir, additional, Laney, Phillip, additional, Hunter, Ross, additional, Cheng, Shi-Chi, additional, Wright, Thomas, additional, Chapman, Neil, additional, Arnold, Ahran, additional, Nowbar, Alexandra, additional, Janmohamed, Azara, additional, Corden, Ben, additional, Cook, Christopher, additional, Rajkumar, Christopher, additional, Keene, Daniel, additional, Thompson, David, additional, Seligman, Henry, additional, Howard, James, additional, Davies, Justin, additional, Sweeney, Mark, additional, Shun-Shin, Matthew, additional, Foley, Michael, additional, Quaife, Nicholas, additional, Al-Lamee, Rasha, additional, Hadjiphilippou, Savvas, additional, Sen, Sayan, additional, Ahmad, Yousif, additional, Shimizu, Hayato, additional, Waki, Hirotaka, additional, Narita, Keisuke, additional, Shimpo, Masahisa, additional, Hoshide, Satoshi, additional, Komori, Takahiro, additional, Ogoyama, Yukako, additional, Ogata, Yukiyo, additional, Oba, Yusuke, additional, Bisharat, Mohanned, additional, Lishmanov, Anton, additional, Jeffords, Travis, additional, Ghali, Magdi, additional, Chia, Beth, additional, Onsrud, Rachel, additional, Rough, Randolph, additional, Tomii, Daijiro, additional, Mori, Fumiko, additional, Kikushima, Hosei, additional, Ninomiya, Kai, additional, Yahagi, Kazuyuki, additional, Tanabe, Kengo, additional, Nakamura, Kosuke, additional, Komiyama, Kota, additional, Nakase, Masaaki, additional, Asami, Masahiko, additional, Setoguchi, Naoto, additional, Tanaka, Tetsu, additional, Horiuchi, Yu, additional, Watanabe, Yusuke, additional, Feldman, Dmitriy, additional, Bergman, Geoffrey, additional, Sherifi, Ines, additional, Kim, Luke, additional, Amin, Nivee, additional, Minutello, Robert, additional, Wong, S. Chiu, additional, McCullough, Stephen, additional, D'Souza, Richard, additional, Kurdi, Hibba, additional, Statton, Sarah, additional, Watkinson, Tony, additional, Bertolet, Barry, additional, Gupta, Amit, additional, Blossom, Benjamin, additional, Bell, Chris, additional, Hill, Douglas, additional, Sierra, Francisco, additional, Johnson, James, additional, Estess, John, additional, Adams, Joseph, additional, McDuffie, Katie, additional, Ferguson, Lee, additional, Little, Nelson, additional, Ballard, Richard Dane, additional, Williams, Roger, additional, Ikeda, Wanda, additional, Calhoun, William, additional, Carroll, William, additional, Singh, Avneet, additional, Hirsh, Benjamin, additional, Meraj, Perwaiz, additional, Jauhar, Rajiv, additional, Golwala, Harsh, additional, Rueda, Jose, additional, Graham, Kellie, additional, Al-Hakim, Ramsey, additional, Rope, Robert, additional, Kandzari, David, additional, Bahrami, Dariush, additional, Reedus, Denise, additional, David, Shukri, additional, Rehman, Iram, additional, Zakaria, Khalid, additional, Choksi, Nishit, additional, Kazziha, Samer, additional, Kumar, Sarwan, additional, Saba, Souheil, additional, Steigerwalt, Susan, additional, Sirajeldin, Yassir, additional, Hyder, Omar, additional, Aronow, Herbert, additional, Connors, Andrea, additional, Shemin, Douglas, additional, Bent, Clare, additional, Levy, Terry, additional, Kodoth, Vivek, additional, Schlaich, Markus, additional, Kiuchi, Marcio, additional, Carnagarin, Revathy, additional, Torre, Sabino, additional, Levitt, Howard, additional, Chen, Lin, additional, Fan, Sarah, additional, Waxman, Sergio, additional, Porr, Wendy, additional, Mangos, George, additional, Smyth, Brendan, additional, Lane, Cathie, additional, Sader, Mark, additional, Patel, Kirit Kumar, additional, Rao, Anjani, additional, Milford, Brett, additional, Ahluwalia, Guneet, additional, Sennott, Jaqueline, additional, Field, Justin, additional, Jena, Nihar, additional, Loree, Stacy, additional, Graham, John, additional, Al-Hesayen, Abdul, additional, Bagai, Akshay, additional, Shite, Junya, additional, Kozuki, Amane, additional, Suzuki, Atsushi, additional, Masuko, Eri, additional, Soga, Fumitaka, additional, Asada, Hiroyuki, additional, Shibata, Hiroyuki, additional, Nagoshi, Ryoji, additional, Fujiwara, Ryudo, additional, Kyo, Shokan, additional, Miyata, Tomohiro, additional, Kijima, Yoichi, additional, Griesinger, Lena, additional, Hafer, Lukas, additional, Starick, Rene-Alexander, additional, Keil, Sebastian, additional, Desch, Udo, additional, Saito, Shigeru, additional, Koyama, Eiji, additional, Yamanaka, Futoshi, additional, Yokoyama, Hiroaki, additional, Tobita, Kazuki, additional, Shishido, Koki, additional, Yamaguchi, Masashi, additional, Murakami, Masato, additional, Moriyama, Noriaki, additional, Takahashi, Saeko, additional, Mizuno, Shingo, additional, Yokota, Shohei, additional, Hayashi, Takahiro, additional, Yamada, Takashi, additional, Yamagishi, Tamiharu, additional, Sugiyama, Yoichi, additional, Mashimo, Yuka, additional, Tamaki, Yusuke, additional, Tanaka, Yutaka, additional, Lee, David, additional, Yeung, Alan, additional, Noel, Thomas, additional, Umana, Ernesto, additional, Katopodis, John, additional, Dixon, William, additional, Walton, Tony, additional, Rischin, Adam, additional, Chee, Adrian, additional, Leaney, Alexandra, additional, Fernando, Himavan, additional, Hopper, Ingrid, additional, Bloom, Jason, additional, Fairley, Jessica, additional, Stehli, Julia, additional, Segan, Julian, additional, Sharma, Meenal, additional, Fitzgerald, Melissa, additional, Papandony, Michelle, additional, Whyler, Naomi, additional, Noaman, Samer, additional, Ali, Shazeea, additional, Jefferson, Brian, additional, Reyes, David, additional, Johnston, Thomas, additional, Höfling, Alexander, additional, Berger, Ann-Kathrin, additional, Cremers, Bodo, additional, Millenaar, Dominic, additional, Zivanovic, Ina, additional, Lucic, Jelena, additional, Dederer, Juliane, additional, Fischer, Patrick, additional, Kulenthiran, Saarraangan, additional, Ewen, Sebastian, additional, Bewarder, Yvonne, additional, Schmieder, Roland, additional, Bosch, Agnes, additional, Ott, Christian, additional, Kannenkeril, Dennis, additional, Akarca, Ertan, additional, Kistner, Iris, additional, Kolwelter, Julie, additional, Bihlmaier, Karl, additional, Striepe, Kristina, additional, Karg, Marina, additional, Günes-Altan, Merve, additional, Anna Friedrich, Stefanie Sofia, additional, Jung, Susanne, additional, Dienemann, Thomas, additional, Ziakas, Antonios, additional, Kouparanis, Antonios, additional, Pagiantza, Areti, additional, Peteinidou, Emmanouela, additional, Didagelos, Matthaios, additional, Psochias, Polykarpos Akis, additional, Shishehbor, Mehdi, additional, Meade, Ashley, additional, Linetsky, Elena, additional, Robinson, Monique, additional, Kotter, John, additional, Ziada, Khaled, additional, Bachinsky, William, additional, Garton, Alex, additional, Stuck, Jason, additional, Papademetriou, Vasilios, additional, Chung, Annise, additional, Li, Ping, additional, Nagpal, Sameer, additional, Remetz, Michael, additional, Shah, Samit, additional, and Lynch, Shannon, additional

Published
2023
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70. New Users of Angiotensin II Receptor Blocker–Versus Angiotensin‐Converting Enzyme Inhibitor–Based Antihypertensive Medication Regimens and Cardiovascular Disease Events: A Secondary Analysis of ACCORD‐BP and SPRINT

Author

King, Jordan B., primary, Berchie, Ransmond O., additional, Derington, Catherine G., additional, Marcum, Zachary A., additional, Scharfstein, Daniel O., additional, Greene, Tom H., additional, Herrick, Jennifer S., additional, Jacobs, Joshua A., additional, Zheutlin, Alexander R., additional, Bress, Adam P., additional, and Cohen, Jordana B., additional

Published
2023
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71. Associations of cardiometabolic polygenic risk scores with cardiovascular disease in African Americans

Author

Workalemahu, Tsegaselassie, primary, Ying, Jian, additional, G., Berhanu Gebremeskel, additional, Lu, Tianyuan, additional, Mohanty, April, additional, Elfassy, Tali, additional, Tekola-Ayele, Fasil, additional, A., Timothy Thornton, additional, Cohen, Jordana, additional, R., Marguerite Irvin, additional, M., Robert Silver, additional, W., Michael Varner, additional, Yaffe, Kristine, additional, Fornage, Myriam, additional, M., Donald Lloyd-Jones, additional, Sims, Mario, additional, Shimbo, Daichi, additional, Yano, Yuichiro, additional, Muntner, Paul, additional, and Bress, Adam, additional

Published
2023
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77. Identifying Patients for Intensive Blood Pressure Treatment Based on Cognitive Benefit

Author

Ghazi, Lama, primary, Shen, Jincheng, additional, Ying, Jian, additional, Derington, Catherine G., additional, Cohen, Jordana B., additional, Marcum, Zachary A., additional, Herrick, Jennifer S., additional, King, Jordan B., additional, Cheung, Alfred K., additional, Williamson, Jeff D., additional, Pajewski, Nicholas M., additional, Bryan, Nick, additional, Supiano, Mark, additional, Sonnen, Josh, additional, Weintraub, William S., additional, Greene, Tom H., additional, and Bress, Adam P., additional

Published
2023
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78. Prognostic utility of rhythmic components in 24-hour ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity

Author

El Jamal, Nadim, primary, Brooks, Thomas G, additional, Cohen, Jordana, additional, Townsend, Raymond R, additional, Rodriguez de Sosa, Giselle, additional, Shah, Vallabh, additional, Nelson, Robert G, additional, Drawz, Paul E, additional, Rao, Panduranga, additional, Bhat, Zeenat, additional, Chang, Alexander, additional, Yang, Wei, additional, FitzGerald, Garret A, additional, and Skarke, Carsten, additional

Published
2023
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79. Blood Pressure, Incident Cognitive Impairment, and Severity of CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Babroudi, Seda, primary, Tighiouart, Hocine, additional, Schrauben, Sarah J., additional, Cohen, Jordana B., additional, Fischer, Michael J., additional, Rahman, Mahboob, additional, Hsu, Chi-yuan, additional, Sozio, Stephen M., additional, Weir, Matthew, additional, Sarnak, Mark, additional, Yaffe, Kristine, additional, Tamura, Manjula Kurella, additional, Drew, David, additional, Appel, Lawrence J., additional, Chen, Jing, additional, Cohen, Debbie L., additional, Feldman, Harold I., additional, Go, Alan S., additional, Lash, James P., additional, Nelson, Robert G., additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional

Published
2023
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80. Aldosterone Level Predicts Hypertension After ICH in the REDUCE Trial (P3-5.013)

Author

Zabinska, Julia, primary, Peng, Teng, additional, Forman, Rachel, additional, Schwartz, Anna, additional, Leasure, Audrey, additional, Schlechter, Maia, additional, Falcone, Guido, additional, De Havenon, Adam, additional, Sansing, Lauren, additional, Lalwani, Dheeraj, additional, Parasuram, Nethra, additional, Yadlapalli, Vineetha, additional, Bushnell, Cheryl, additional, Mullen, Michael, additional, Cohen, Jordana, additional, Cohen, Debbie, additional, Messe, Steven, additional, and Sheth, Kevin, additional

Published
2023
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81. Proteomic cardiovascular risk assessment in chronic kidney disease

Author

Deo, Rajat, primary, Dubin, Ruth F, additional, Ren, Yue, additional, Murthy, Ashwin C, additional, Wang, Jianqiao, additional, Zheng, Haotian, additional, Zheng, Zihe, additional, Feldman, Harold, additional, Shou, Haochang, additional, Coresh, Josef, additional, Grams, Morgan, additional, Surapaneni, Aditya L, additional, Bhat, Zeenat, additional, Cohen, Jordana B, additional, Rahman, Mahboob, additional, He, Jiang, additional, Saraf, Santosh L, additional, Go, Alan S, additional, Kimmel, Paul L, additional, Vasan, Ramachandran S, additional, Segal, Mark R, additional, Li, Hongzhe, additional, and Ganz, Peter, additional

Published
2023
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84. Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure

Author

Chirinos, Julio A., Cohen, Jordana B., Zhao, Lei, Hanff, Thomas, Sweitzer, Nancy, Fang, James, Corrales-Medina, Vicente, Ammar, Ron, Morley, Michael, Zamani, Payman, Bhattacharya, Priyanka, Brandimarto, Jeff, Jia, Yi, Basso, Michael D., Wang, Zhaoqing, Ebert, Christina, Ramirez-Valle, Francisco, Schafer, Peter H., Seiffert, Dietmar, Gordon, David A., and Cappola, Thomas

Published
2020
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89. Prognostic utility of rhythmic components in 24-hour ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity

Author

Jamal, Nadim El, Brooks, Thomas G., Cohen, Jordana, Townsend, Raymond R., Rodriguez de Sosa, Giselle, Shah, Vallabh, Nelson, Robert G., Drawz, Paul E., Rao, Panduranga, Bhat, Zeenat, Chang, Alexander, Yang, Wei, FitzGerald, Garret A., and Skarke, Carsten

Subjects
Article
Abstract

BACKGROUND: Chronic kidney disease (CKD) represents a significant global burden. Hypertension is a modifiable risk factor for rapid progression of CKD. METHODS: We extend the risk stratification by introducing the non-parametric determination of rhythmic components in 24-hour profiles of ambulatory blood pressure monitoring (ABPM) in the African American Study for Kidney Disease and Hypertension (AASK) cohort and the Chronic Renal Insufficiency Cohort (CRIC) using Cox proportional hazards models. RESULTS: We find that rhythmic profiling of BP through JTK_Cycle analysis identifies subgroups of CRIC participants at advanced risk of cardiovascular death. CRIC participants with a history of cardiovascular disease (CVD) and absent cyclic components in their BP profile had at any time a 3.4-times higher risk of cardiovascular death than CVD patients with cyclic components present in their BP profile (HR: 3.38, 95% CI: 1.45-7.88, p =0.005). This substantially increased risk was independent of whether ABPM followed a dipping or non-dipping pattern whereby non-dipping or reverse dipping were not significantly associated with cardiovascular death in patients with prior CVD ( p >0.1). In the AASK cohort, unadjusted models demonstrate a higher risk in reaching end stage renal disease among participants without rhythmic ABPM components (HR:1.80, 95% CI: 1.10-2.96); however, full adjustment abolished this association. CONCLUSIONS: This study proposes rhythmic blood pressure components as a novel biomarker to unmask excess risk among CKD patients with prior cardiovascular disease.

Published
2023

91. PROTEOMIC CORRELATES OF PLASMA POTASSIUM (K+) IN HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)

Author

Steinberg, Rebecca S., primary, Salman, Oday, additional, Zhao, Lei, additional, Qian, Chenao, additional, Cohen, Jordana, additional, Zamani, Payman, additional, Ebert, Christina, additional, Sharma, Ankur, additional, Wang, Zhaoqing, additional, Greenawalt, Danielle, additional, Van Empel, Vanessa, additional, Richards, Mark, additional, Doughty, Rob N., additional, Rietzschel, Ernst R., additional, Javaheri, Ali, additional, Schafer, Peter, additional, Borentain, Maria, additional, Seiffert, Dietmar, additional, Chang, Ching-Pin, additional, Gordon, David, additional, Ramirez-Valle, Francisco, additional, Mann, Douglas L., additional, Morris, Alanna A., additional, Cappola, Thomas P., additional, and Chirinos, Julio A., additional

Published
2023
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92. URINARY PROTEINS LEVELS ASSOCIATED WITH OUTCOMES IN HEART FAILURE WITH PRESERVED EJECTION FRACTION

Author

Carland, Corinne, primary, Zhao, Lei, additional, Salman, Oday, additional, Cohen, Jordana, additional, Zamani, Payman, additional, Xiao, Qing, additional, Dongre, Ashok R., additional, Wang, Zhaoqing, additional, Ebert, Christina, additional, Greenawalt, Danielle, additional, Van Empel, Vanessa, additional, Richards, Mark, additional, Doughty, Rob N., additional, Rietzschel, Ernst R., additional, Javaheri, Ali, additional, Wang, Yixin, additional, Schafer, Peter, additional, Hersey, Sarah, additional, Chang, Ching-Pin, additional, Gordon, David, additional, Ramirez-Valle, Francisco, additional, Mann, Douglas L., additional, Cappola, Thomas P., additional, and Chirinos, Julio A., additional

Published
2023
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93. PROTEOMIC ASSOCIATIONS OF N-TERMINAL (NT)-PRO HORMONE BNP (NT-PROBNP) IN HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)

Author

Salman, Oday, primary, Zhao, Lei, additional, Zamani, Payman, additional, Cohen, Jordana, additional, Gunawardhana, Kushan, additional, Kammerhoff, Karl, additional, Greenawalt, Danielle, additional, Wang, Zhaoqing, additional, Rietzschel, Ernst R., additional, Van Empel, Vanessa, additional, Richards, A. Mark, additional, Doughty, Rob N., additional, Javaheri, Ali, additional, Schafer, Peter, additional, Borentain, Maria, additional, Seiffert, Dietmar, additional, Chang, Ching-Pin, additional, Gordon, David, additional, Ramirez-Valle, Francisco, additional, Mann, Douglas L., additional, Cappola, Thomas P., additional, and Chirinos, Julio A., additional

Published
2023
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94. EFFECT OF SPIRONOLACTONE ON THE PLASMA PROTEOME IN HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF): IMPACT OF BASELINE N-TERMINAL (NT)-PRO B-TYPE NATRIURETIC PEPTIDE (BNP) LEVELS

Author

Salman, Oday, primary, Zhao, Lei, additional, Zamani, Payman, additional, Cohen, Jordana, additional, Gunawardhana, Kushan, additional, Kammerhoff, Karl, additional, Greenawalt, Danielle, additional, Wang, Zhaoqing, additional, Rietzschel, Ernst R., additional, Van Empel, Vanessa, additional, Richards, A. Mark, additional, Doughty, Rob N., additional, Javaheri, Ali, additional, Schafer, Peter, additional, Borentain, Maria, additional, Seiffert, Dietmar, additional, Chang, Ching-Pin Chang Ching-Pin, additional, Gordon, David, additional, Mann, Douglas L., additional, Cappola, Thomas P., additional, and Chirinos, Julio A., additional

Published
2023
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97. Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study

Author

Ehrlich, Avner, primary, Ioannidis, Konstantinos, additional, Nasar, Makram, additional, Abu Alkian, Ismaeel, additional, Daskal, Yuval, additional, Atari, Nofar, additional, Kliker, Limor, additional, Rainy, Nir, additional, Hofree, Matan, additional, Shafran Tikva, Sigal, additional, Houri, Inbal, additional, Cicero, Arrigo, additional, Pavanello, Chiara, additional, Sirtori, Cesare R, additional, Cohen, Jordana B, additional, Chirinos, Julio A, additional, Deutsch, Lisa, additional, Cohen, Merav, additional, Gottlieb, Amichai, additional, Bar-Chaim, Adina, additional, Shibolet, Oren, additional, Mandelboim, Michal, additional, Maayan, Shlomo L, additional, and Nahmias, Yaakov, additional

Published
2023
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98. Author response: Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study

Author

Ehrlich, Avner, primary, Ioannidis, Konstantinos, additional, Nasar, Makram, additional, Abu Alkian, Ismaeel, additional, Daskal, Yuval, additional, Atari, Nofar, additional, Kliker, Limor, additional, Rainy, Nir, additional, Hofree, Matan, additional, Shafran Tikva, Sigal, additional, Houri, Inbal, additional, Cicero, Arrigo, additional, Pavanello, Chiara, additional, Sirtori, Cesare R, additional, Cohen, Jordana B, additional, Chirinos, Julio A, additional, Deutsch, Lisa, additional, Cohen, Merav, additional, Gottlieb, Amichai, additional, Bar-Chaim, Adina, additional, Shibolet, Oren, additional, Mandelboim, Michal, additional, Maayan, Shlomo L, additional, and Nahmias, Yaakov, additional

Published
2023
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100. Socioeconomic characteristics of those with peripheral artery disease in the chronic renal insufficiency cohort

Author

Stoecker, Jordan B, Cohen, Jordana B, Belkin, Nathan, Chen, Jing C, Townsend, Raymond R, Xie, Dawei, Feldman, Harold I, and Wang, Grace J

Subjects
Radiology, Nuclear Medicine and imaging, Surgery, General Medicine, Cardiology and Cardiovascular Medicine, Article
Abstract

Background The association between socioeconomic factors and peripheral arterial disease (PAD) has not been as well characterized as other cardiovascular conditions. We sought to define how annual income and education level are associated with PAD in a well-characterized diverse set of adults with chronic kidney disease (CKD). Methods The Chronic Renal Insufficiency Cohort Study (CRIC) is a multi-center, prospective cohort study designed to examine risk factors for progression of CKD and cardiovascular disease. Demographic, income, and education-level data, as well as clinical data including ankle-brachial index (ABI) were collected at baseline. Annual income was categorized as < $25,000, $25,000–50,000, $50,000–100,000, or above $100,000; educational level was categorized as some high school, high school graduate, some college, or college graduate. Participants with missing income data or incompressible ABI (>1.4) were excluded from initial analysis. Logistic regression was used to estimate the association of income and/or education level with PAD, defined as an enrollment ABI of Results A total of 4122 were included, mean age of participants was 59.5 years, 56% were male, and 44% were Black. There were 763 CRIC participants with PAD at study enrollment (18.5%). In the final multivariable logistic regression model, Black race (OR = 1.3, 95% CI 1.1–1.6, p = 0.004) and level of annual household income remained independently associated with PAD at the time of enrollment (income $100,000 (overall p-value Conclusions In this prospectively followed CKD cohort, lower annual household income and Black race were significantly associated with increased PAD at study enrollment. In contrast, educational level was not associated with PAD when adjusted for patient income data. Black race, female gender, and low income were independently associated with decreased statin use, populations which could be targets of future public health programs.

Published
2022

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