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Portulaca oleracea L., known as the “vegetable for long life,” is an annual succulent herb that is widely distributed worldwide. Many clinical and experimental studies have demonstrated that purslane seed (MCXZ) can be used as an adjunctive and alternative therapy for the treatment of diabetes mellitus (DM). However, the underlying active constituents and pharmacological mechanisms through which MCXZ exerts effects in DM remain unclear. In the present study, we confirmed that MCXZ treatment resulted in hypoglycemic activity, lowering the fasting blood glucose and glycated hemoglobin levels in streptozotocin-induced diabetic mice. Then, ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry was used to systematically analyze the chemical profile of MCXZ, resulting in the identification of 84 constituents, including 31 organic acids and nine flavonoids. Finally, the Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine was employed to analyze the key active components of MCXZ and the molecular mechanisms through which these components acted in DM. Ten key active compounds were identified based on the topological importance of their corresponding putative targets within the known DM-associated therapeutic target network of known MCXZ putative targets. Functionally, these candidate targets play critical anti-hyperlipidemia, anti-hyperglycemia, immunity regulation, and inflammatory roles involving DM-related pathways, such as the vascular endothelial growth factor (VEGF) signaling pathway and Fc gamma R-mediated phagocytosis, which indicated that MCXZ exhibited anti-diabetic activity through multi-faced actions.

In the context of the rapid development of blockchain technology, smart contracts have also been widely used in the Internet of Things, finance, healthcare, and other fields. There has been an explosion in the number of smart contracts, and at the same time, the security of smart contracts has received widespread attention because of the financial losses caused by smart contract vulnerabilities. Existing analysis tools can detect many smart contract security vulnerabilities, but because they rely too heavily on hard rules defined by experts when detecting smart contract vulnerabilities, the time to perform the detection increases significantly as the complexity of the smart contract increases. In the present study, we propose a novel hybrid deep learning model named CBGRU that strategically combines different word embedding (Word2Vec, FastText) with different deep learning methods (LSTM, GRU, BiLSTM, CNN, BiGRU). The model extracts features through different deep learning models and combine these features for smart contract vulnerability detection. On the currently publicly available dataset SmartBugs Dataset-Wild, we demonstrate that the CBGRU hybrid model has great smart contract vulnerability detection performance through a series of experiments. By comparing the performance of the proposed model with that of past studies, the CBGRU model has better smart contract vulnerability detection performance.

Blockchain presents a chance to address the security and privacy issues of the Internet of Things; however, blockchain itself has certain security issues. How to accurately identify smart contract vulnerabilities is one of the key issues at hand. Most existing methods require large-scale data support to avoid overfitting; machine learning (ML) models trained on small-scale vulnerability data are often difficult to produce satisfactory results in smart contract vulnerability prediction. However, in the real world, collecting contractual vulnerability data requires huge human and time costs. To alleviate these problems, this paper proposed an ensemble learning (EL)-based contract vulnerability prediction method, which is based on seven different neural networks using contract vulnerability data for contract-level vulnerability detection. Seven neural network (NN) models were first pretrained using an information graph (IG) consisting of source datasets, which then were integrated into an ensemble model called Smart Contract Vulnerability Detection method based on Information Graph and Ensemble Learning (SCVDIE). The effectiveness of the SCVDIE model was verified using a target dataset composed of IG, and then its performances were compared with static tools and seven independent data-driven methods. The verification and comparison results show that the proposed SCVDIE method has higher accuracy and robustness than other data-driven methods in the target task of predicting smart contract vulnerabilities.

Infrared (IR) target detection is an important technology in the field of remote sensing image application. The methods for IR image target detection are affected by many characteristics, such as poor texture information and low contrast. These characteristics bring great challenges to infrared target detection. To address the above problem, we propose a novel target detection method for IR images target detection in this paper. Our method is improved from two aspects: Firstly, we propose a novel residual thermal infrared network (ResTNet) as the backbone in our method, which is designed to improve the feature extraction ability for low contrast targets by Transformer structure. Secondly, we propose a contrast enhancement loss function (CTEL) that optimizes the weights about the loss value of the low contrast targets’ prediction results to improve the effect of learning low contrast targets and compensate for the gradient of the low-contrast targets in training back propagation. Experiments on FLIR-ADAS dataset and our remote sensing dataset show that our method is far superior to the state-of-the-art ones in detecting low-contrast targets of IR images. The mAP of the proposed method reaches 84% on the FLIR public dataset. This is the best precision in published papers. Compared with the baseline, the performance on low-contrast targets is improved by about 20%. In addition, the proposed method is state-of-the-art on the FLIR dataset and our dataset. The comparative experiments demonstrate that our method has strong robustness and competitiveness.

Since the COVID-19 outbreak in 2020, China’s air pollution has been significantly affected by control measures on industrial production and human activities. In this study, we analyzed the temporal variations of NO2 concentrations during the COVID-19 lockdown and post-epidemic era in 11 Chinese megacities by using satellite and ground-based remote sensing as well as in situ measurements. The average satellite tropospheric vertical column density (TVCD) of NO2 by TROPOMI decreased by 39.2–71.93% during the 15 days after Chinese New Year when the lockdown was at its most rigorous compared to that of 2019, while the in situ NO2 concentration measured by China National Environmental Monitoring Centre (CNEMC) decreased by 42.53–69.81% for these cities. Such differences between both measurements were further investigated by using ground-based multi-axis differential optical absorption spectroscopy (MAX-DOAS) remote sensing of NO2 vertical profiles. For instance, in Beijing, MAX-DOAS NO2 showed a decrease of 14.19% (versus 18.63% by in situ) at the ground surface, and 36.24% (versus 36.25% by satellite) for the total tropospheric column. Thus, vertical discrepancies of atmospheric NO2 can largely explain the differences between satellite and in situ NO2 variations. In the post-epidemic era of 2021, satellite NO2 TVCD and in situ NO2 concentrations decreased by 10.42–64.96% and 1.05–34.99% compared to 2019, respectively, possibly related to the reduction of the transportation industry. This study reveals the changes of China’s urban NO2 pollution in the post-epidemic era and indicates that COVID-19 had a profound impact on human social activities and industrial production.

Ship detection based on synthetic aperture radar (SAR) images has made a breakthrough in recent years. However, small ships, which may be regarded as speckle noise, pose enormous challenges to the accurate detection of SAR images. In order to enhance the detection performance of small ships in SAR images, a novel detection method named a spatial information integration network (SII-Net) is proposed in this paper. First, a channel-location attention mechanism (CLAM) module which extracts position information along with two spatial directions is proposed to enhance the detection ability of the backbone network. Second, a high-level features enhancement module (HLEM) is customized to reduce the loss of small target location information in high-level features via using multiple pooling layers. Third, in the feature fusion stage, a refined branch is presented to distinguish the location information between the target and the surrounding region by highlighting the feature representation of the target. The public datasets LS-SSDD-v1.0, SSDD and SAR-Ship-Dataset are used to conduct ship detection tests. Extensive experiments show that the SII-Net outperforms state-of-the-art small target detectors and achieves the highest detection accuracy, especially when the target size is less than 30 pixels by 30 pixels.

Hyperspectral image classification (HSIC) methods usually require more training samples for better classification performance. However, a large number of labeled samples are difficult to obtain because it is cost- and time-consuming to label an HSI in a pixel-wise way. Therefore, how to overcome the problem of insufficient accuracy and stability under the condition of small labeled training sample size (SLTSS) is still a challenge for HSIC. In this paper, we proposed a novel multiple superpixel graphs learning method based on adaptive multiscale segmentation (MSGLAMS) for HSI classification to address this problem. First, the multiscale-superpixel-based framework can reduce the adverse effect of improper selection of a superpixel segmentation scale on the classification accuracy while saving the cost to manually seek a suitable segmentation scale. To make full use of the superpixel-level spatial information of different segmentation scales, a novel two-steps multiscale selection strategy is designed to adaptively select a group of complementary scales (multiscale). To fix the bias and instability of a single model, multiple superpixel-based graphical models obatined by constructing superpixel contracted graph of fusion scales are developed to jointly predict the final results via a pixel-level fusion strategy. Experimental results show that the proposed MSGLAMS has better performance when compared with other state-of-the-art algorithms. Specifically, its overall accuracy achieves 94.312%, 99.217%, 98.373% and 92.693% on Indian Pines, Salinas and University of Pavia, and the more challenging dataset Houston2013, respectively.

Single-beacon navigation for group autonomous underwater vehicles (AUVs) suffers from long navigation period and asynchronization. This paper addresses the problem by introducing the single-input-multiple-output (SIMO) model, where, a single AUV transmits the signal and other AUVs receive the signal. Utilizing the time-delay of signals from the beacon and the sender, the navigation for all AUVs is achieved simultaneously, and the navigation period is dramatically decreased. Moreover, based on the new SIMO model, a tracking method utilizing extended Kalman filter is also put forward to increase the navigation precision and reduce the computational burden. Finally, a coordinate fusion algorithm based on the location, error, and time-delay is presented, which fuses the independent AUV coordinates to be a higher precision holistic coordinate system for group AUVs. Simulation results show the effectiveness of the proposed method.

A novel framework for 3D reconstruction of buildings based on a single off-nadir satellite image is proposed in this paper. Compared with the traditional methods of reconstruction using multiple images in remote sensing, recovering 3D information that utilizes the single image can reduce the demands of reconstruction tasks from the perspective of input data. It solves the problem that multiple images suitable for traditional reconstruction methods cannot be acquired in some regions, where remote sensing resources are scarce. However, it is difficult to reconstruct a 3D model containing a complete shape and accurate scale from a single image. The geometric constraints are not sufficient as the view-angle, size of buildings, and spatial resolution of images are different among remote sensing images. To solve this problem, the reconstruction framework proposed consists of two convolutional neural networks: Scale-Occupancy-Network (Scale-ONet) and model scale optimization network (Optim-Net). Through reconstruction using the single off-nadir satellite image, Scale-Onet can generate water-tight mesh models with the exact shape and rough scale of buildings. Meanwhile, the Optim-Net can reduce the error of scale for these mesh models. Finally, the complete reconstructed scene is recovered by Model-Image matching. Profiting from well-designed networks, our framework has good robustness for different input images, with different view-angle, size of buildings, and spatial resolution. Experimental results show that an ideal reconstruction accuracy can be obtained both on the model shape and scale of buildings.

In recent years, some algorithms based on sparse representation have been proposed to improve the detection performance for hyperspectral anomaly detection. Among these algorithms, the background joint sparse representation (BJSR) algorithm adaptively selects the most representative background bases for the local region and can obtain satisfactory results. However, BJSR mainly considers spectral characteristics of hyperspectral image. In this paper, we propose a BJSR-based spectral–spatial method. BJSR is first employed to process the original hyperspectral image in spectral domain. Then, linear local tangent space alignment (LLTSA) is used to obtain the low-dimensional manifold of the hyperspectral image. Next, spatial BJSR is used to process the low-dimensional manifold obtained by LLTSA. Finally, the proposed algorithm combines spectral BJSR with spatial BJSR to detect the anomaly targets. The experimental results demonstrate that the proposed algorithm can achieve a better performance when compared with the comparison algorithms.

It is of great interest in exploiting spectral-spatial information for hyperspectral image (HSI) classification at different spatial resolutions. This paper proposes a new spectral-spatial deep learning-based classification paradigm. First, pixel-based scale transformation and class separability criteria are employed to measure appropriate spatial resolution HSI, and then we integrate the spectral and spatial information (i.e., both implicit and explicit features) together to construct a joint spectral-spatial feature set. Second, as a deep learning architecture, stacked sparse autoencoder provides strong learning performance and is expected to exploit even more abstract and high-level feature representations from both spectral and spatial domains. Specifically, random forest (RF) classifier is first introduced into stacked sparse autoencoder for HSI classification, based on the fact that it provides better tradeoff among generalization performance, prediction accuracy and operation speed compared to other traditional procedures. Experiments on two real HSIs demonstrate that the proposed framework generates competitive performance.

Node localization is the core in wireless sensor network. It can be solved by powerful beacons, which are equipped with global positioning system devices to know their location information. In this article, we present a novel sparse localization approach with a mobile beacon based on LU decomposition. Our scheme firstly translates node localization problem into a 1-sparse vector recovery problem by establishing sparse localization model. Then, LU decomposition pre-processing is adopted to solve the problem that measurement matrix does not meet the re¬stricted isometry property. Later, the 1-sparse vector can be exactly recovered by compressive sensing. Finally, as the 1-sparse vector is approximate sparse, weighted Cen¬troid scheme is introduced to accurately locate the node. Simulation and analysis show that our scheme has better localization performance and lower requirement for the mobile beacon than MAP+GC, MAP-M, and MAP-MN schemes. In addition, the obstacles and DOI have little effect on the novel scheme, and it has great localization performance under low SNR, thus, the scheme proposed is robust.

Anomaly detection has received considerable interest for hyperspectral data exploitation due to its high spectral resolution. A well-known algorithm for hyperspectral anomaly detection is the RX detector. A number of variations have been studied since then, including global and local versions for different type of anomalies. Aiming at a real-time requirement for practical applications, this paper extends the concept of global and local anomaly detectors to be real-time detectors. The algorithms exploit the fact that a true real-time detector must produce its output in a causal manner and at the same time as an input comes in. Taking advantage of the Woodbury matrix identity, the global and local real-time detectors can be implemented and processed pixel-by-pixel in real time. Both synthetic and real hyperspectral imagery are conducted to demonstrate their performance.

The authors wish to make the following corrections to this paper [1]:[...]

The authors wish to make the following corrections to this paper [...]

Mitochondrial dysfunction plays a key role in the progression of Alzheimer's disease (AD). The accumulation of amyloid-beta peptide (Aβ) in the brains of AD patients is thought to be closely related to neuronal mitochondrial dysfunction and oxidative stress. Therefore, protecting mitochondria from Aβ-induced neurotoxicity is an effective strategy for AD therapeutics. In a previous study, we found that geniposide, a pharmacologically active compound purified from gardenia fruit, has protective effects on oxidative stress and mitochondrial dysfunction in AD transgenic mouse models. However, whether geniposide has a protective effect on Aβ-induced neuronal dysfunction remains unknown. In the present study, we demonstrate that geniposide protects cultured primary cortical neurons from Aβ-mediated mitochondrial dysfunction by recovering ATP generation, mitochondrial membrane potential (MMP), and cytochrome c oxidase (CcO) and caspase 3/9 activity; by reducing ROS production and cytochrome c leakage; as well as by inhibiting apoptosis. These findings suggest that geniposide may attenuate Aβ-induced neuronal injury by inhibiting mitochondrial dysfunction and oxidative stress.

In this paper, we proposed a novel object-based dense matching method specially for the high-precision disparity map of building objects in urban areas, which can maintain accurate object structure characteristics. The proposed framework mainly includes three stages. Firstly, an improved edge line extraction method is proposed for the edge segments to fit closely to building outlines. Secondly, a fusion method is proposed for the outlines under the constraint of straight lines, which can maintain the building structural attribute with parallel or vertical edges, which is very useful for the dense matching method. Finally, we proposed an edge constraint and outline compensation (ECAOC) dense matching method to maintain building object structural characteristics in the disparity map. In the proposed method, the improved edge lines are used to optimize matching search scope and matching template window, and the high-precision building outlines are used to compensate the shape feature of building objects. Our method can greatly increase the matching accuracy of building objects in urban areas, especially at building edges. For the outline extraction experiments, our fusion method verifies the superiority and robustness on panchromatic images of different satellites and different resolutions. For the dense matching experiments, our ECOAC method shows great advantages for matching accuracy of building objects in urban areas compared with three other methods.

In the paper, we propose a novel object-oriented hierarchy radiation consistency method for dense matching of different temporal and different sensor data in the 3D reconstruction. For different temporal images, our illumination consistency method is proposed to solve both the illumination uniformity for a single image and the relative illumination normalization for image pairs. Especially in the relative illumination normalization step, singular value equalization and linear relationship of the invariant pixels is combined used for the initial global illumination normalization and the object-oriented refined illumination normalization in detail, respectively. For different sensor images, we propose the union group sparse method, which is based on improving the original group sparse model. The different sensor images are set to a similar smoothness level by the same threshold of singular value from the union group matrix. Our method comprehensively considered the influence factors on the dense matching of the different temporal and different sensor stereoscopic image pairs to simultaneously improve the illumination consistency and the smoothness consistency. The radiation consistency experimental results verify the effectiveness and superiority of the proposed method by comparing two other methods. Moreover, in the dense matching experiment of the mixed stereoscopic image pairs, our method has more advantages for objects in the urban area.

In this paper, a novel framework of the 3D reconstruction of buildings is proposed, focusing on remote sensing super-generalized stereo-pairs (SGSPs). As we all know, 3D reconstruction cannot be well performed using nonstandard stereo pairs, since reliable stereo matching could not be achieved when the image-pairs are collected at a great difference of views, and we always failed to obtain dense 3D points for regions of buildings, and cannot do further 3D shape reconstruction. We defined SGSPs as two or more optical images collected in less constrained views but covering the same buildings. It is even more difficult to reconstruct the 3D shape of a building by SGSPs using traditional frameworks. As a result, a dynamic multi-projection-contour approximating (DMPCA) framework was introduced for SGSP-based 3D reconstruction. The key idea is that we do an optimization to find a group of parameters of a simulated 3D model and use a binary feature-image that minimizes the total differences between projection-contours of the building in the SGSPs and that in the simulated 3D model. Then, the simulated 3D model, defined by the group of parameters, could approximate the actual 3D shape of the building. Certain parameterized 3D basic-unit-models of typical buildings were designed, and a simulated projection system was established to obtain a simulated projection-contour in different views. Moreover, the artificial bee colony algorithm was employed to solve the optimization. With SGSPs collected by the satellite and our unmanned aerial vehicle, the DMPCA framework was verified by a group of experiments, which demonstrated the reliability and advantages of this work.

The Kernel-RX detector (KRXD) has attracted widespread interest in hyperspectral image processing with the utilization of nonlinear information. However, the kernelization of hyperspectral data leads to poor execution efficiency in KRXD. This paper presents an approach to the progressive line processing of KRXD (PLP-KRXD) that can perform KRXD line by line (the main data acquisition pattern). Parallel causal sliding windows are defined to ensure the causality of PLP-KRXD. Then, with the employment of the Woodbury matrix identity and the matrix inversion lemma, PLP-KRXD has the capacity to recursively update the kernel matrices, thereby avoiding a great many repetitive calculations of complex matrices, and greatly reducing the algorithm’s complexity. To substantiate the usefulness and effectiveness of PLP-KRXD, three groups of hyperspectral datasets are used to conduct experiments.

In this paper, a building extraction method is proposed based on a stacked sparse autoencoder with an optimized structure and training samples. Building extraction plays an important role in urban construction and planning. However, some negative effects will reduce the accuracy of extraction, such as exceeding resolution, bad correction and terrain influence. Data collected by multiple sensors, as light detection and ranging (LIDAR), optical sensor etc., are used to improve the extraction. Using digital surface model (DSM) obtained from LIDAR data and optical images, traditional method can improve the extraction effect to a certain extent, but there are some defects in feature extraction. Since stacked sparse autoencoder (SSAE) neural network can learn the essential characteristics of the data in depth, SSAE was employed to extract buildings from the combined DSM data and optical image. A better setting strategy of SSAE network structure is given, and an idea of setting the number and proportion of training samples for better training of SSAE was presented. The optical data and DSM were combined as input of the optimized SSAE, and after training by an optimized samples, the appropriate network structure can extract buildings with great accuracy and has good robustness.

The kernel RX (KRX) detector proposed by Kwon and Nasrabadi exploits a kernel function to obtain a better detection performance. However, it still has two limits that can be improved. On the one hand, reasonable integration of spatial-spectral information can be used to further improve its detection accuracy. On the other hand, parallel computing can be used to reduce the processing time in available KRX detectors. Accordingly, this paper presents a novel weighted spatial-spectral kernel RX (WSSKRX) detector and its parallel implementation on graphics processing units (GPUs). The WSSKRX utilizes the spatial neighborhood resources to reconstruct the testing pixels by introducing a spectral factor and a spatial window, thereby effectively reducing the interference of background noise. Then, the kernel function is redesigned as a mapping trick in a KRX detector to implement the anomaly detection. In addition, a powerful architecture based on the GPU technique is designed to accelerate WSSKRX. To substantiate the performance of the proposed algorithm, both synthetic and real data are conducted for experiments.

Abstract: Real-time anomaly detection has received wide attention in remote sensing image processing because many moving targets must be detected on a timely basis. A widely-used anomaly detection algorithm is the Reed-Xiaoli (RX) algorithm that was proposed by Reed and Yu. The kernel RX algorithm proposed by Kwon and Nasrabadi is a nonlinear version of the RX algorithm and outperforms the RX algorithm in terms of detection accuracy. However, the kernel RX algorithm is computationally more expensive. This paper presents a novel real-time anomaly detection framework based on the kernel RX algorithm. In the kernel RX detector, the inverse covariance matrix and the estimated mean of the background data in the kernel space are non-causal and computationally inefficient. In this work, a local causal sliding array window is used to ensure the causality of the detection system. Using the matrix inversion lemma and the Woodbury matrix identity, both the inverse covariance matrix and estimated mean can be recursively derived without extensive repetitive calculations, and, therefore, the real-time kernel RX detector can be implemented and processed pixel-by-pixel in real time. To substantiate its effectiveness and utility in real-time anomaly detection, real hyperspectral data sets are utilized for experiments.

Node localization technology is especially important to most applications of wireless sensor network. However, each mobile beacon needs to broadcast its current position many times, and locating all the nodes must take a long time in most of the localization algorithms. In order to solve these problems, we propose a novel range-free localization algorithm—localization with a mobile beacon based on compressive sensing (LMCS). LMCS makes use of compressive sensing (CS) to get the related degree of the sensor nodes and all the mobile beacon points. According to the related degree, the algorithm decides the weight value of each beacon point for the mass coordinate, and estimates the sensor node location. LMCS does not ask for all nodes hearing directly with beacon node, so it is more suitable for practical application than other localization algorithms. The simulation results show that compared with MAP schemes, LMCS has better localization performance, especially under irregularity of radio range and obstacle environment. Therefore, LMCS is a reliable, useful, and effective localization algorithm.

Leber congenital amaurosis (LCA) is one of the most severe forms of inherited retinal degeneration and can be caused by mutations in at least 15 different genes. To clarify the proteomic differences in LCA eyes, a cohort of retinal degeneration 12 (rd12) mice, an LCA2 model caused by a mutation in the RPE65 gene, were injected subretinally with an AAV vector (scAAV5-smCBA-hRPE65) in one eye, while the contralateral eye served as a control. Proteomics were compared between untreated rd12 and normal control retinas on P14 and P21, and among treated and untreated rd12 retinas and control retinas on P42. Gene therapy in rd12 mice restored retinal function in treated eyes, which was demonstrated by electroretinography (ERG). Proteomic analysis successfully identified 39 proteins expressed differently among the 3 groups. The expression of 3 proteins involved in regulation of apoptosis and neuroptotection (alpha A crystallin, heat shock protein 70 and peroxiredoxin 6) were investigated further. Immunofluorescence, Western blot and real-time PCR confirmed the quantitative changes in their expression. Furthermore, cell culture studies suggested that peroxiredoxin 6 could act in an antioxidant role in rd12 mice. Our findings support the feasibility of gene therapy in LCA2 patients and support a role for alpha A crystallin, heat shock protein 70 and peroxiredoxin 6 in the pathogenetic mechanisms involved in LCA2 disease process.