88 results on '"Christian Witzel"'
Search Results
52. Significance of melanin distribution in the epidermis for the protective effect against UV light.
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Zamudio Díaz, Daniela F., Busch, Loris, Kröger, Marius, Klein, Anna Lena, Lohan, Silke B., Mewes, Karsten R., Vierkotten, Lars, Witzel, Christian, Rohn, Sascha, and Meinke, Martina C.
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MELANINS ,EPIDERMIS ,ULTRAVIOLET radiation ,ULTRAVIOLET lamps ,FLUORIMETRY ,DNA damage - Abstract
Melanin, the most abundant skin chromophore, is produced by melanocytes and is one of the key components responsible for mediating the skin's response to ultraviolet radiation (UVR). Because of its antioxidant, radical scavenging, and broadband UV absorbing properties, melanin reduces the penetration of UVR into the nuclei of keratinocytes. Despite its long-established photoprotective role, there is evidence that melanin may also induce oxidative DNA damage in keratinocytes after UV exposure and therefore be involved in the development of melanoma. The present work aimed at evaluating the dependence of UV-induced DNA damage on melanin content and distribution, using reconstructed human epidermis (RHE) models. Tanned and light RHE were irradiated with a 233 nm UV-C LED source at 60 mJ/cm
2 and a UV lamp at 3 mJ/cm2 . Higher UV-mediated free radicals and DNA damage were detected in tanned RHE with significantly higher melanin content than in light RHE. The melanin distribution in the individual models can explain the lack of photoprotection. Fluorescence lifetime-based analysis and Fontana–Masson staining revealed a non-homogeneous distribution and absence of perinuclear melanin in the tanned RHE compared to the in vivo situation in humans. Extracellularly dispersed epidermal melanin interferes with photoprotection of the keratinocytes. [ABSTRACT FROM AUTHOR]- Published
- 2024
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53. Far‐UVC‐ and UVB‐induced DNA damage depending on skin type.
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Busch, Loris, Kröger, Marius, Zamudio Díaz, Daniela F., Schleusener, Johannes, Lohan, Silke B., Ma, Jackie, Witzel, Christian, Keck, Cornelia M., and Meinke, Martina C.
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DNA damage ,RADIATION sources ,MELANINS ,WRINKLES (Skin) ,PYRIMIDINES ,SKIN aging ,CYCLOBUTANE - Abstract
Far‐UVC radiation sources of wavelengths 222 nm and 233 nm represent an interesting potential alternative for the antiseptic treatment of the skin due to their high skin compatibility. Nevertheless, no studies on far‐UVC‐induced DNA damage in different skin types have been published to date, which this study aims for. After irradiating the skin with far‐UVC of the wavelengths 222 and 233 nm as well as broadband UVB, the tissue was screened for cyclobutane pyrimidine dimer‐positive (CPD+) cells using immunohistochemistry. The epidermal DNA damage was lower in dark skin types than in fair skin types after irradiation at 233 nm. Contrary to this, irradiation at 222 nm caused no skin type‐dependent differences, which can be attributed to the decreased penetration depth of radiation. UVB showed the relatively strongest differences between light and dark skin types when using a suberythemal dose of 3 mJ/cm2. As melanin is known for its photoprotective effect, we evaluated the ratio of melanin content in the stratum basale and stratum granulosum in samples of different skin types using two‐photon excited fluorescence lifetime imaging (TPE‐FLIM) finding a higher ratio up to skin type IV–V. As far‐UVC is known to penetrate only into the upper layers of the viable skin, the aforementioned melanin ratio could explain the less pronounced differences between skin types after irradiation with far‐UVC compared to UVB. [ABSTRACT FROM AUTHOR]
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- 2023
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54. Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy.
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Freise, Lennart, Behncke, Rose Yinghan, Allerkamp, Hanna Helene, Sandermann, Tim Henrik, Chu, Ngoc Hai, Funk, Eva Maria, Hondrich, Lukas Jonathan, Riedel, Alina, Witzel, Christian, Hansmeier, Nils Rouven, Danyel, Magdalena, Gellhaus, Alexandra, Dechend, Ralf, and Hägerling, René
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MICROSCOPY ,CARDIOVASCULAR system ,VASCULAR remodeling ,BLOOD vessels ,THREE-dimensional imaging - Abstract
The placenta is the first embryonic organ, representing the connection between the embryo and the mother, and is therefore necessary for the embryo's growth and survival. To meet the ever-growing need for nutrient and gas exchange, the maternal spiral arteries undergo extensive remodeling, thus increasing the uteroplacental blood flow by 16-fold. However, the insufficient remodeling of the spiral arteries can lead to severe pregnancy-associated disorders, including but not limited to pre-eclampsia. Insufficient endovascular trophoblast invasion plays a key role in the manifestation of pre-eclampsia; however, the underlying processes are complex and still unknown. Classical histopathology is based on two-dimensional section microscopy, which lacks a volumetric representation of the vascular remodeling process. To further characterize the uteroplacental vascularization, a detailed, non-destructive, and subcellular visualization is beneficial. In this study, we use light sheet microscopy for optical sectioning, thus establishing a method to obtain a three-dimensional visualization of the vascular system in the placenta. By introducing a volumetric visualization method of the placenta, we could establish a powerful tool to deeply investigate the heterogeneity of the spiral arteries during the remodeling process, evaluate the state-of-the-art treatment options, effects on vascularization, and, ultimately, reveal new insights into the underlying pathology of pre-eclampsia. [ABSTRACT FROM AUTHOR]
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- 2023
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55. PRECYCLE: multicenter, randomized phase IV intergroup trial to evaluate the impact of eHealth-based patient-reported outcome (PRO) assessment on quality of life in patients with hormone receptor positive, HER2 negative locally advanced or metastatic breast cancer treated with palbociclib and an aromatase inhibitor or palbociclib and fulvestrant
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Degenhardt, Tom, Fasching, Peter A, Lüftner, Diana, Müller, Volkmar, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Schem, Christian, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Decker, Thomas, Tesch, Hans, Kümmel, Sherko, Uleer, Christoph, Wuerstlein, Rachel, Hoffmann, Oliver, Warm, Mathias, Marschner, Norbert, Schinköthe, Timo, Kates, Ronald E, Schumacher, Johannes, Otremba, Burkhard, Zaiss, Matthias, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Schmidt, Marcus, PreCycle Investigators, Degenhardt, Tom, Fasching, Peter A, Lüftner, Diana, Müller, Volkmar, Thomssen, Christoph; https://orcid.org/0000-0002-9324-2396, Schem, Christian, Witzel, Isabell; https://orcid.org/0000-0002-8734-4521, Decker, Thomas, Tesch, Hans, Kümmel, Sherko, Uleer, Christoph, Wuerstlein, Rachel, Hoffmann, Oliver, Warm, Mathias, Marschner, Norbert, Schinköthe, Timo, Kates, Ronald E, Schumacher, Johannes, Otremba, Burkhard, Zaiss, Matthias, Harbeck, Nadia; https://orcid.org/0000-0002-9744-7372, Schmidt, Marcus, and PreCycle Investigators
- Abstract
Background Efficacy and quality of life (QoL) are key criteria for therapy selection in metastatic breast cancer (MBC). In hormone receptor positive (HR +) human epidermal growth factor receptor 2 negative (HER2 −) MBC, addition of targeted oral agents such as everolimus or a cycline-dependent kinase 4/6 (CDK 4/6) inhibitor (e.g., palbociclib, ribociclib, abemaciclib) to endocrine therapy substantially prolongs progression-free survival and in the case of a CDK 4/6i also overall survival. However, the prerequisite is adherence to therapy over the entire course of treatment. However, particularly with new oral drugs, adherence presents a challenge to disease management. In this context, factors influencing adherence include maintaining patients’ satisfaction and early detection/management of side effects. New strategies for continuous support of oncological patients are needed. An eHealth-based platform can help to support therapy management and physician–patient interaction. Methods PreCycle is a multicenter, randomized, phase IV trial in HR + HER2 − MBC. All patients (n = 960) receive the CDK 4/6 inhibitor palbociclib either in first (62.5%) or later line (37.5%) together with endocrine therapy (AI, fulvestrant) according to national guidelines. PreCycle evaluates and compares the time to deterioration (TTD) of QoL in patients supported by eHealth systems with substantially different functionality: CANKADO active vs. inform. CANKADO active is the fully functional CANKADO-based eHealth treatment support system. CANKADO inform is a CANKADO-based eHealth service with a personal login, documentation of daily drug intake, but no further functions. To evaluate QoL, the FACT-B questionnaire is completed at every visit. As little is known about relationships between behavior (e.g., adherence), genetic background, and drug efficacy, the trial includes both patient-reported outcome and biomarker screening for discovery of forecast models for adherence, symptoms, QoL, progres
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- 2023
56. Hepatic artery reconstruction using an operating microscope in pediatric liver transplantation—Is it worth the effort?
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Dziodzio, Tomasz, Martin, Friederike, Gül‐Klein, Safak, Globke, Brigitta, Ritschl, Paul Viktor, Jara, Maximilian, Hillebrandt, Karl‐Herbert, Nösser, Maximilian, Koulaxouzidis, Georgios, Fehrenbach, Uli, Gratopp, Alexander, Henning, Stephan, Bufler, Philipp, Schöning, Wenzel, Schmelzle, Moritz, Pratschke, Johann, Witzel, Christian, and Öllinger, Robert
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HEPATIC artery ,LIVER transplantation ,GRAFT survival ,MICROSCOPES ,MULTIVARIATE analysis - Abstract
Introduction: In pediatric liver transplantation (pLT), hepatic artery thrombosis (HAT) is associated with inferior transplant outcome. Hepatic artery reconstruction (HAR) using an operating microscope (OM) is considered to reduce the incidence of HAT. Methods: HAR using an OM was compared to a historic cohort using surgical loupes (SL) in pLT performed between 2009 and 2020. Primary endpoint was the occurrence of HAT. Secondary endpoints were 1‐year patient and graft survival determined by Kaplan–Meier analysis and complications. Multivariate analysis was used to identify independent risk factors for HAT and adverse events. Results: A total of 79 pLTs were performed [30 (38.0%) living donations; 49 (62.0%) postmortem donations] divided into 23 (29.1%) segment 2/3, 32 (40.5%) left lobe, 4 (5.1%) extended right lobe, and 20 (25.3%) full‐size grafts. One‐year patient and graft survival were both 95.2% in the OM group versus 86.2% and 77.8% in the SL group (p =.276 and p =.077). HAT rate was 0% in the OM group versus 24.1% in the SL group (p =.013). One‐year patient and graft survival were 64.3% and 35.7% in patient with HAT, compared to 93.9% and 92.8% in patients with no HAT (both p <.001). Multivariate analysis revealed HAR with SL (p =.022) and deceased donor liver transplantation (DDLT) (p =.014) as independent risk factors for HAT. The occurrence of HAT was independently associated with the need for retransplantation (p <.001) and biliary leakage (p =.045). Conclusion: In pLT, the use of an OM is significantly associated to reduce HAT rate, biliary complications, and graft loss and outweighs the disadvantages of delayed arterial perfusion and prolonged warm ischemia time (WIT). [ABSTRACT FROM AUTHOR]
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- 2022
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57. Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models.
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Zwicker, Paula, Schleusener, Johannes, Lohan, Silke B., Busch, Loris, Sicher, Claudia, Einfeldt, Sven, Kneissl, Michael, Kühl, Anja A., Keck, Cornelia M., Witzel, Christian, Kramer, Axel, and Meinke, Martina C.
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METHICILLIN-resistant staphylococcus aureus ,DNA damage ,RISK assessment ,LIGHT sources ,VISIBLE spectra - Abstract
A newly developed UVC LED source with an emission wavelength of 233 nm was proved on bactericidal efficacy and skin tolerability. The bactericidal efficacy was qualitatively analysed using blood agar test. Subsequently, quantitative analyses were performed on germ carrier tests using the MRSA strain DSM11822, the MSSA strain DSM799, S. epidermidis DSM1798 with various soil loads. Additionally, the compatibility of the germicidal radiation doses on excised human skin and reconstructed human epidermis was proved. Cell viability, DNA damage and production of radicals were assessed in comparison to typical UVC radiation from discharge lamps (222 nm, 254 nm) and UVB (280–380 nm) radiation for clinical assessment. At a dose of 40 mJ/cm
2 , the 233 nm light source reduced the viable microorganisms by a log10 reduction (LR) of 5 log10 levels if no soil load was present. Mucin and protein containing soil loads diminished the effect to an LR of 1.5–3.3. A salt solution representing artificial sweat (pH 8.4) had only minor effects on the reduction. The viability of the skin models was not reduced and the DNA damage was far below the damage evoked by 0.1 UVB minimal erythema dose, which can be regarded as safe. Furthermore, the induced damage vanished after 24 h. Irradiation on four consecutive days also did not evoke DNA damage. The radical formation was far lower than 20 min outdoor visible light would cause, which is classified as low radical load and can be compensated by the antioxidant defence system. [ABSTRACT FROM AUTHOR]- Published
- 2022
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58. Disclosure List.
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COVID-19 - Published
- 2021
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59. Research from Charite University Hospital and School of Medicine Provide New Insights into Dendritic Cell Transplants (Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants).
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DENDRITIC cells ,HINDLIMB ,IMMUNE response ,UNIVERSITY hospitals ,CD antigens - Abstract
A recent study conducted by researchers at Charite University Hospital and School of Medicine in Berlin, Germany, has provided new insights into dendritic cell transplants. The study focused on the impact of donor-derived conventional dendritic cells (cDCs) and antigen-presenting cells (APCs) on the immunogenicity of skin and skin-containing vascularized composite tissue allografts (VCA). The researchers found that the skin component of VCA exhibited heightened immunogenicity compared to the entire VCA, and the depletion of donor cDCs and APCs reduced the immunogenicity of skin grafts while having minimal impact on VCA. These findings highlight the highly immunogenic nature of the skin component in VCA and suggest potential strategies for improving the outcomes of organ transplantation. [Extracted from the article]
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- 2024
60. Solvent Effects on Skin Penetration and Spatial Distribution of the Hydrophilic Nitroxide Spin Probe PCA Investigated by EPR.
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Dong, Pin, Teutloff, Christian, Lademann, Jürgen, Patzelt, Alexa, Schäfer-Korting, Monika, and Meinke, Martina C.
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Oxidative stress occurs in extrinsic skin aging processes and diseases when the enhanced production of free radicals exceeds the homeostatic antioxidant capacity of the skin. The spin probe, 3-(carboxy)-2,2,5,5-tetramethylpyrrolidin-1-oxyl (PCA), is frequently used to study the cutaneous radical production by electron paramagnetic resonance (EPR) spectroscopy. This approach requires delivering PCA into the skin, yet solvent effects on the skin penetration and spatial distribution of PCA have not been thoroughly investigated. Three solvents of ethanol, phosphate-buffered saline (PBS) and ethanol-PBS (1:1) were studied. For both human and porcine skin ex vivo, the amount of PCA in the stratum corneum (SC) was the lowest when using ethanol and very similar for PBS and ethanol-PBS. The highest amount of PCA in the viable skin layers was detected for ethanol-PBS, yet it only took up less than 5% of the total amount. The majority of PCA was localized in the SC, among which PCA with high mobility was predominantly distributed in the hydrophilic microenvironment of corneocytes and PCA with lower mobility was mainly in the less hydrophilic microenvironment of intercellular skin lipids. A higher ethanol concentration in the solvent could improve the distribution of PCA in the hydrophilic microenvironments of the SC. The results suggest that ethanol-PBS (1:1) is best-suited for delivering most PCA deep into the skin. This work enhances the understanding of solvent effects on the skin penetration and distribution of PCA and supports the utilization of PCA in studying cutaneous radical production. [ABSTRACT FROM AUTHOR]
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- 2020
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61. The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate – Retrospective Single-centre 10-Year Experience.
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Munder, Beatrix, Andree, Christoph, Witzel, Christian, Fertsch, Sonia, Stambera, Peter, Schulz, Tino, Fleischer, Olaf, Hagouan, Mazen, Grüter, Lukas, Aufmesser, Birgit, Staemmler, Katinka, Kornetka, Julia, Aldeeri, Mohammed, Seidenstücker, Katrin, Abu-Ghazaleh, Alina, and Wolter, Andreas
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- 2020
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62. Outcome after pediatric liver transplantation for staged abdominal wall closure with use of biological mesh—Study with long‐term follow‐up.
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Gül‐Klein, Safak, Dziodzio, Tomasz, Martin, Friederike, Kästner, Anika, Witzel, Christian, Globke, Brigitta, Jara, Maximilian, Ritschl, Paul Viktor, Henning, Stephan, Gratopp, Alexander, Bufler, Philip, Schöning, Wenzel, Schmelzle, Moritz, Pratschke, Johann, and Öllinger, Robert
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ABDOMINAL wall ,LIVER transplantation ,HERNIA - Abstract
Abdominal wall closure after pediatric liver transplantation (pLT) in infants may be hampered by graft‐to‐recipient size discrepancy. Herein, we describe the use of a porcine dermal collagen acellular graft (PDCG) as a biological mesh (BM) for abdominal wall closure in pLT recipients. Patients <2 years of age, who underwent pLT from 2011 to 2014, were analyzed, divided into definite abdominal wall closure with and without implantation of a BM. Primary end‐point was the occurrence of postoperative abdominal wall infection. Secondary end‐points included 1‐ and 5‐year patient and graft survival and the development of abdominal wall hernia. In five out of 21 pLT recipients (23.8%), direct abdominal wall closure was achieved, whereas 16 recipients (76.2%) received a BM. BM removal was necessary in one patient (6.3%) due to abdominal wall infection, whereas no abdominal wall infection occurred in the no‐BM group. No significant differences between the two groups were observed for 1‐ and 5‐year patient and graft survival. Two late abdominal wall hernias were observed in the BM group vs none in the no‐BM group. Definite abdominal wall closure with a BM after pLT is feasible and safe when direct closure cannot be achieved with comparable postoperative patient and graft survival rates. [ABSTRACT FROM AUTHOR]
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- 2020
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63. Surgical workflow for fully navigated high sacral amputation in sacral chordoma.
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Goldberg, Johannes, Bayerl, Simon Heinrich, Witzel, Christian, Aigner, Felix, Ames, Christopher P., and Vajkoczy, Peter
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AMPUTATION ,SURGICAL & topographical anatomy ,WORKFLOW ,INFRARED cameras ,OPERATIVE surgery ,BOWEL & bladder training - Abstract
The method of choice for treatment of sacral chordomas is en bloc tumor removal via sacrectomy or sacral amputation in varying degrees depending on the initial tumor extent. Besides local tumor control, the preservation of neurological function is equally important to minimize postoperative bladder and bowel dysfunction. Removal of sacral tumors is complicated by the complex regional anatomy of the pelvis and the surrounding visceral and retroperitoneal structures. We aim to describe the surgical workflow for a fully navigated high sacral amputation facilitated by integration of an intraoperative computed tomography (iCT)-based spinal navigation system. An iCT-based spinal navigation system (AIRO® CT scanner, Brainlab AG, Feldkirchen, Germany) was used to perform intraoperative navigation with an image-guidance system and infrared tracking camera (BrainLab CurveTM, Brainlab AG, Feldkirchen, Germany) in combination with the spinal navigation set by Brainlab (Brainlab AG, Feldkirchen, Germany) to perform a fully navigated high sacral amputation. We demonstrate the successful implementation of iCT-based spinal navigation during high sacral amputation and the key advantages of this technique throughout the surgery. iCT-based spinal navigation is a useful complementing technique for en bloc high sacral amputations that renders the surgery safer and more accurate. [ABSTRACT FROM AUTHOR]
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- 2020
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64. Charite University Hospital and School of Medicine Researchers Update Current Study Findings on Thrombocytopenia (Moderate LMWH Anticoagulation Improves Success Rate of Hind Limb Allotransplantation in Mice).
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HINDLIMB ,UNIVERSITY hospitals ,RESEARCH personnel ,THROMBOCYTOPENIA ,BLOOD platelet disorders - Abstract
A study conducted by researchers at Charite University Hospital and School of Medicine in Berlin, Germany, has found that moderate low molecular weight heparin (LMWH) anticoagulation improves the success rate of hind limb allotransplantation in mice. The researchers performed fifty allogeneic hind limb transplantations using different anticoagulation protocols and found that treatment with a moderate dose of LMWH reduced thromboembolic events and improved graft and animal survival. The study suggests that LMWH could be used to prevent vascular complications in hind limb transplants. [Extracted from the article]
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- 2024
65. Chemical stabilization of polymers: Implications for dermal exposure to additives.
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Bartsch, N., Girard, M., Schneider, L., Weijgert, V. Van De, Wilde, A., Kappenstein, O., Vieth, B., Hutzler, C., and Luch, A.
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POLYMERS ,ADDITIVES ,CHEMICAL stability ,GAS chromatography/Mass spectrometry (GC-MS) ,PERMEATION tubes ,FOURIER transform infrared spectroscopy - Abstract
Technical benefits of additives in polymers stand in marked contrast to their associated health risks. Here, a multi-analyte method based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) was developed to quantify polymer additives in complex matrices such as low-density polyethylene (LDPE) and isolated human skin layers after dermal exposure
ex vivo . That way both technical aspects and dermal exposure were investigated. The effects of polymer additivation on the material were studied using the example of LDPE. To this end, a tailor-made polymer was applied in aging studies that had been furnished with two different mixtures of phenol- and diarylamine-based antioxidants, plasticizers and processing aids. Upon accelerated thermo-oxidative aging of the material, the formation of LDPE degradation products was monitored with attenuated total reflectance—Fourier transformed infrared (ATR-FTIR) spectroscopy. Compared to pure LDPE, a protective effect of added antioxidants could be observed on the integrity of the polymer. Further, thermo-oxidative degradation of the additives and its kinetics were investigated using LDPE or squalane as matrix. The half-lives of additives in both matrices revealed significant differences between the tested additives as well as between LDPE and squalane. For instance, 2-tert -butyl-6-[(3-tert -butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol (Antioxidant 2246) showed a half-life 12 times lower when incorporated in LDPE as compared to squalane. As a model for dermal exposure of consumers, human skin was brought into contact with the tailor-made LDPE containing additivesex vivo in static Franz diffusion cells. The skin was then analyzed for additives and decomposition products. This study proved 10 polymer additives of diverse pysicochemical properties and functionalities to migrate out of the polymer and eventually overcome the intact human skin barrier during contact. Moreover, their individual distribution within distinct skin layers was demonstrated. This is exemplified by the penetration of the procarcinogenic antioxidantN -phenylnaphthalen-2-amine (Neozon D) into the viable epidermis and the permeation through the skin of the neurotoxic plasticizerN -butylbenzenesulfonamide (NBBS). In addition, the analyses of additive degradation products in the isolated skin layers revealed the presence of 2-tert -butyl-4-methylphenol in all layers after contact to a polymer with substances of origin like Antioxidant 2246. Thus, attention needs to be paid to absorption of polymer additives together with their degradation products when it comes to dermal exposure assessment. [ABSTRACT FROM AUTHOR]- Published
- 2018
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66. Investigators from Charite University Hospital and School of Medicine Zero in on Life Science (Far-uvc- and Uvb-induced Dna Damage Depending On Skin Type).
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LIFE sciences ,DNA damage ,UNIVERSITY hospitals ,SCIENCE journalism ,DNA - Abstract
Keywords for this news article include: Berlin, Germany, Europe, Life Science, DNA Damage, DNA Research, Deoxyribonucleic Acid, Drugs and Therapies, Genetics, Proteomics, Charite University Hospital and School of Medicine. Keywords: Berlin; Germany; Europe; Life Science; DNA Damage; DNA Research; Deoxyribonucleic Acid; Drugs and Therapies; Genetics; Proteomics EN Berlin Germany Europe Life Science DNA Damage DNA Research Deoxyribonucleic Acid Drugs and Therapies Genetics Proteomics 1231 1231 1 09/11/23 20230915 NES 230915 2023 SEP 15 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Life Science. [Extracted from the article]
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- 2023
67. Skin permeation of polycyclic aromatic hydrocarbons: A solvent-based in vitro approach to assess dermal exposures against benzo[ a ]pyrene and dibenzopyrenes.
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Bartsch, N., Heidler, J., Vieth, B., Hutzler, C., and Luch, A.
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BENZOPYRANS ,PERMEABILITY ,POLYCYCLIC aromatic hydrocarbons ,SKIN ,SOLVENTS ,IN vitro studies - Abstract
Consumer products with high contents of polycyclic aromatic hydrocarbons (PAHs) were repeatedly identified by market surveillance authorities. Since several of the individual compounds have been identified as genotoxic carcinogens, there might be health risks associated with the usage of these items. It therefore becomes reasonable to argue to reduce PAH contents in consumer products to a level as low as possible. This study presents data on the migration of PAHs from consumer products into aqueous sweat simulant or aqueous ethanol and on its combined migration and penetration into human skin. Product specimens were either submerged in simulant, or placed directly on test skins in Franz cell chambers to simulate dermal contacts. Migration of hexacyclic dibenzopyrenes became detectable by using ethanolic simulant, but not in aqueous sweat simulant. Similarly, migration of the pentacyclic model carcinogen benzo[a]pyrene (B[a]P) into aqueous sweat simulant was significantly lower when compared with human skin or skin models. The results point to a gross underestimation (about two orders of magnitude) when using aqueous sweat simulant instead of human skin for assessing PAH migration. On the other side, the usage of 20% ethanol as simulant revealed good agreement to the actual exposure of human skin against B[a]P migrating out of contaminated products. Our results underline that aqueous sweat simulant is not suitable to study dermal migration of highly lipophilic compounds. [ABSTRACT FROM PUBLISHER]
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- 2016
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68. Aktuelle Erkenntnisse zur Eigenfett Transplantation anhand der neuen Leitlinie „Autologe Fetttransplantation“.
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Prantl, L., Rennekampff, H. O., Giunta, R. E., Harder, Y., von Heimburg, D., Heine, N., Herold, C., Kneser, U., Lampert, F., Machens, H. G., Mirastschijski, U., Müller, D., Pallua, N., Schantz, T., Schönborn, A., Ueberreiter, K., Witzel, CH., Bull, G., Rezek, D., and Sattler, G.
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- 2016
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69. Researcher from Charite - University Medicine Berlin Reports Recent Findings in Preeclampsia (Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy).
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MICROSCOPY ,PREECLAMPSIA ,BLOOD vessels ,PLACENTA ,PREGNANCY complications - Abstract
Eclampsia, Health and Medicine, Obstetrics, Preeclampsia, Pregnancy Complications, Pregnancy-Induced Hypertension, Women's Health Keywords: Eclampsia; Health and Medicine; Obstetrics; Preeclampsia; Pregnancy Complications; Pregnancy-Induced Hypertension; Women's Health EN Eclampsia Health and Medicine Obstetrics Preeclampsia Pregnancy Complications Pregnancy-Induced Hypertension Women's Health 423 423 1 07/10/23 20230711 NES 230711 2023 JUL 13 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on preeclampsia. Keywords for this news article include: Charite - University Medicine Berlin, Obstetrics, Preeclampsia, Women's Health, Health and Medicine, Pregnancy Complications, Pregnancy-Induced Hypertension. [Extracted from the article]
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- 2023
70. Electrical Nerve Stimulation Enhances Perilesional Branching after Nerve Grafting but Fails to Increase Regeneration Speed in a Murine Model.
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Witzel, Christian, Brushart, Thomas M., Koulaxouzidis, Georgios, and Infanger, Manfred
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NEURAL stimulation ,NERVE grafting ,CRUSH syndrome ,FLUORESCENT proteins ,AXONS ,FIBRIN tissue adhesive - Abstract
Background Electrical stimulation immediately following nerve lesion helps regenerating axons cross the subsequently grafted nerve repair site. However, the results and the mechanisms remain open to debate. Some findings show that stimulation after crush injury increases axonal crossing of the repair site without affecting regeneration speed. Others show that stimulation after transection and fibrin glue repair doubles regeneration distance. Methods Using a sciatic-nerve-transection-graft in vivo model, we investigated the morphological behavior of regenerating axons around the repair site after unilateral nerve stimulation (20 Hz, 1 hour). With mice expressing axonal fluorescent proteins (thy1-YFP), we were able to calculate the following at 5 and 7 days: percentage of regenerating axons and arborizing axons, branches per axon, and regeneration distance and speed. Results Brief stimulation significantly increases the percentage of regenerating axons (5 days: 35.5 vs. 27.3% nonstimulated, p < 0.05; 7 days: 43.3 vs. 33.9% nonstimulated, p < 0.05), mainly by increasing arborizing axons (5 days: 49.3 [4.4] vs. 33.9 [4.1]% [p < 0.001]; 7 days: 42.2 [5.6] vs. 33.2 [3.1]% [p < 0.001]). Neither branches per arborizing axon nor regeneration speed were affected. Conclusion Ourmorphological data analysis revealed that electrical stimulation in this model increases axonal crossing of the repair site and promotes homogeneous perilesional branching, but does not affect regeneration speed. [ABSTRACT FROM AUTHOR]
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- 2016
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71. In Situ Deactivation of Interleukin-6 Enhances Early Peripheral Nerve Regeneration in a Murine Injury Model.
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Koulaxouzidis, Georgios, Reim, Gernot, Fluhr, Joachim W., Simunovic, Filip, Stark, G. Bjoern, and Witzel, Christian
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INTERLEUKIN-6 ,NERVOUS system regeneration ,AXONS ,FLUORESCENT proteins ,GELATIN - Abstract
Background Systemic alteration of interleukin-6 (IL-6) influences peripheral nerve regeneration. We investigated the potential influences of in situ (at the coaptation site) IL-6 modulation in a peripheral-nerve-transection/sciatic-nerve-graft in vivo model. Methods We quantified the elongation of regenerating axons, the number of arborizing axons, and the number of branches per arborizing axon 7 days after the injury in mice expressing axonal fluorescent proteins (thy-1-YFP mice). Sciatic nerves from nonexpressing mice (C57Bl6 or IL-6
-/- mice) were grafted into those expressing yellow fluorescent protein. We altered the in situ IL-6 concentration by loading a topical gelatin sponge with an inhibiting IL-6 receptor antibody or IL-6 combined with a soluble IL-6 receptor. Sciatic nerves from IL-6-/- mice were grafted into an additional group. The contralateral sham-operated side served as control in all the groups. Results Axonal elongation increased significantly with the in situ application of the IL-6 receptor antibody, while topical IL-6 significantly reduced the regeneration distance. The number of arborizing axons increased significantly in nerves grafted from IL-6-/- mice, whereas branches per arborizing axons remained stable. Conclusion In situ IL-6 receptor inhibition and IL-6-/- nerve grafting enhance early peripheral nerve regeneration in an acute murine injury model. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
72. In vivo stimulation of early peripheral axon regeneration by N-propionylmannosamine in the presence of polysialyltransferase ST8SIA2.
- Author
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Koulaxouzidis, Georgios, Reutter, Werner, Hildebrandt, Herbert, Stark, G., and Witzel, Christian
- Subjects
AXONS ,REGENERATION (Biology) ,MANNOSAMINE ,SIALYLTRANSFERASES ,SIALIC acids ,BIOSYNTHESIS ,CHEMICAL precursors - Abstract
The key enzyme of sialic acid (Sia) biosynthesis is the bifunctional UDP- N-acetylglucosamine 2-epimerase/ManNAc kinase (GNE/MNK). It metabolizes the physiological precursor ManNAc and N-acyl modified analogues such as N-propionylmannosamine (ManNProp) to the respective modified sialic acid. Polysialic acid (polySia) is a crucial compound for several functions in the nervous system and is synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4. PolySia can be modified in vitro and in vivo by metabolic glycoengineering of the N-acyl side chain of Sia. In vitro studies show that the application of ManNProp increases neurite outgrowth and accelerates the re-establishment of functional synapses. In this study, we investigate in vivo how ManNProp application might benefit peripheral nerve regeneration. In mice expressing axonal fluorescent proteins (thy-1-YFP), we transected the sciatic nerve and then replaced part of it with a sciatic nerve graft from non-expressing mice (wild-type mice or St8sia2 mice). Analyses conducted 5 days after grafting showed that systemic application of ManNProp (200 mg/kg, twice a day, i.p.), but not of physiological ManNAc (1 g/kg, twice a day, i.p.), significantly increased the extent of axonal elongation, the number of arborizing axons and the number of branches per regenerating axon within the grafts from wild-type mice, but not in those from St8sia2 mice. The results demonstrate that the application of ManNProp has beneficial effects on early peripheral nerve regeneration and indicate that the stimulation of axon growth depends on ST8SIA2 activity in the nerve graft. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
73. Over 30 Years of Pediatric Liver Transplantation at the Charité—Universitätsmedizin Berlin.
- Author
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Moosburner, Simon, Wiering, Leke, Gül-Klein, Safak, Ritschl, Paul, Dziodzio, Tomasz, Raschzok, Nathanael, Witzel, Christian, Gratopp, Alexander, Henning, Stephan, Bufler, Philip, Schmelzle, Moritz, Lurje, Georg, Schöning, Wenzel, Pratschke, Johann, Globke, Brigitta, and Öllinger, Robert
- Subjects
LIVER transplantation ,SURGICAL complications ,PERIOPERATIVE care ,CHILD patients ,OVERALL survival ,METABOLIC disorders ,BILIARY atresia - Abstract
Background: Pediatric liver transplantation (LT) is the treatment of choice for children with end-stage liver disease and in certain cases of hepatic malignancies. Due to low case numbers, a technically demanding procedure, the need for highly specialized perioperative intensive care, and immunological, as well as infectious, challenges, the highest level of interdisciplinary cooperation is required. The aim of our study was to analyze short- and long-term outcomes of pediatric LT in our center. Methods: We conducted a retrospective single-center analysis of all liver transplantations in pediatric patients (≤16 years) performed at the Department of Surgery, Charité – Universitätsmedizin Berlin between 1991 and 2021. Three historic cohorts (1991–2004, 2005–2014 and 2015–2021) were defined. Graft- and patient survival, as well as perioperative parameters were analyzed. The study was approved by the institutional ethics board. Results: Over the course of the 30-year study period, 212 pediatric LTs were performed at our center. The median patient age was 2 years (IQR 11 years). Gender was equally distributed (52% female patients). The main indications for liver transplantation were biliary atresia (34%), acute hepatic necrosis (27%) and metabolic diseases (13%). The rate of living donor LT was 25%. The median cold ischemia time for donation after brain death (DBD) LT was 9 h and 33 min (IQR 3 h and 46 min). The overall donor age was 15 years for DBD donors and 32 years for living donors. Overall, respective 1, 5, 10 and 30-year patient and graft survivals were 86%, 82%, 78% and 65%, and 78%, 74%, 69% and 55%. One-year patient survival was 85%, 84% and 93% in the first, second and third cohort, respectively (p = 0.14). The overall re-transplantation rate was 12% (n = 26), with 5 patients (2%) requiring re-transplantation within the first 30 days. Conclusion: The excellent long-term survival over 30 years showcases the effectiveness of liver transplantation in pediatric patients. Despite a decrease in DBD organ donation, patient survival improved, attributed, besides refinements in surgical technique, mainly to improved interdisciplinary collaboration and management of perioperative complications. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
74. LAIENGOTTESDIENSTE IN PRIESTERLOSEN GEMEINDEN DES BISTUMS PADERBORN WÄHREND DES KULTURKAMPFES.
- Author
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Müller, Torsten W.
- Published
- 2013
75. Kompetenzaufgaben im Englischunterricht : Grundlagen und Unterrichtsbeispiele
- Author
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Wolfgang Hallet, Ulrich Krämer, Wolfgang Hallet, and Ulrich Krämer
- Abstract
Komplexe Aufgaben im Fokus'Kompetenz'ist zu einem der meist gebrauchten Begriffe im Kontext von Schule, Unterricht und Bildung geworden. Wenn man ihn auf sinnvolle Weise unterrichts- und bildungswirksam realisieren möchte, bedarf es nicht nur einer theoretischen, sondern vor allem einer praxisbezogenen Klärung. Dieses Buch führt aus, wie das Ziel der fremdsprachigen Diskursfähigkeit mit Hilfe der komplexen Kompetenzaufgaben zu erreichen ist: - Im didaktisch-theoretischen Teil werden die für einen kompetenzorientierten Unterricht relevanten Konzepte entwickelt und dargestellt. - Im Praxisteil stellt der Band themenorientierte Unterrichtsbeispiele für alle Stufen vom Beginn der Sekundarstufe I bis zum Abitur vor, die auch die gängigen Arbeitsbereiche des Englischunterrichts abdecken (von den Skills über generische Formen bis hin zur Arbeit mit literarischen und anderen Texten). - Unterrichtsvorschläge zeigen, wie Kompetenzen durch komplexe Aufgaben angebahnt und entwickelt werden und wie man das Erreichen der gewünschten Ziele überprüfen und bewerten kann. - Zugleich erfahren Sie, aus welchen Elementen, Bausteinen und Unterstützungsangeboten eine komplexe Aufgabe bestehen muss, die von den Lernenden in möglichst großer Selbständigkeit bearbeitet werden soll. - Dabei wird auch dem unterschiedlichen Differenzierungsbedarf in heterogenen Lerngruppen Rechnung getragen. - Eine eigene Einheit widmet sich speziell den Kompetenzen für die Berufs- und Arbeitswelt. Komplexe Aufgaben sind kein'Sonderfall'des Englischunterrichts! Nicht zuletzt durch Beispiele ihrer Integration in das Lehrwerk wird deutlich, dass die Arbeit mit komplexen Kompetenzaufgaben der Normalfall eines ganzheitlichen, am Ziel der fremdsprachigen Diskursfähigkeit orientierten Unterrichts sein kann. Eine Publikation der Klett Akademie für Fremdsprachendidaktik. Weitere Informationen finden Sie unter www.klett-akademie.de
- Published
- 2024
76. Präparierkurs : Präparieranweisungen und Theorie
- Author
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Hans Maier, Andreas Winkelmann, Hans Maier, and Andreas Winkelmann
- Subjects
- Dissection
- Abstract
Dieses Buch ist seit seinem erstmaligen Erscheinen vor 40 Jahren zugleich bewährte Präparieranleitung und Kurzlehrbuch für den anatomischen Präparierkurs. Die im Kurs durchgeführten Präparierschritte werden im Detail beschrieben, mögliche Schwierigkeiten werden erläutert und auf gefährdete Strukturen in der unmittelbaren Nachbarschaft wird jeweils rechtzeitig hingewiesen. Eng damit verzahnt wird das erforderliche anatomische Wissen in einprägsamer und übersichtlicher Form dargestellt. Der Lernstoff ist nach der Wichtigkeit für die spätere ärztliche Tätigkeit ausgewählt und mit zahlreichen klinischen Hinweisen bereichert. Für Studierende der Medizin und Zahnmedizin ist das Buch eine ideale Präparier- und Lernhilfe. Auch Assistenten und studentische Tutoren finden hier alle nötigen Erläuterungen, um im Kurs selbstständig arbeiten zu können. Eine ausführliche Einführung in den Präparierkurs und hilfreiche Anhänge runden das Buch ab. In der vorliegenden 6. Auflage wurden sowohl die anatomische Terminologie als auch die Ratschläge und Regeln für den Präparierkurs an die aktuellen Erkenntnisse angepasst.
- Published
- 2024
77. Investigators from Charite University Hospital and School of Medicine Zero in on Life Science (Far-uvc- and Uvb-induced Dna Damage Depending On Skin Type)
- Subjects
DNA -- Reports ,Genetic research -- Reports ,Skin -- Reports ,DNA damage -- Reports ,Physical fitness -- Reports ,Skin care products -- Reports ,Health - Abstract
2023 SEP 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Life Science. According to news reporting from [...]
- Published
- 2023
78. Kopfarbeit : Ein Gehirnchirurg über den schmalen Grat zwischen Leben und Tod | Der SPIEGEL-Bestseller jetzt im Taschenbuch
- Author
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Dr. Peter Vajkoczy and Dr. Peter Vajkoczy
- Abstract
Ungewöhnliche Einblicke in den Alltag der Neurochirurgie - und in das menschliche Gehirn: Ein weltweit renommierter Gehirnchirurg erzählt von außergewöhnlichen Fällen und seinem Alltag im Operations-Saal. Das faszinierende Sachbuch zum Thema Gehirnchirurgie und Neurowissenschaft jetzt im Taschenbuch! Prof. Dr. Peter Vajkoczy ist Direktor der Klinik für Neurochirurgie an der Berliner Charité. Bis zu hundert Patienten aus aller Welt betreut er auf seinen drei Stationen und führt mit seinem Team bis zu fünf, sechs Operationen pro Tag durch - meist geht es um Schlaganfälle, Gehirntumore, Bypässe und Störungen an der Wirbelsäule. Diese Operationen sind körperlich anstrengend, oft zermürbend lang und hochkompliziert. Und alles spielt sich im Mikrobereich ab: Der Operateur sieht das, was er tut, nur durch ein Mikroskop in bis zu vierzigfacher Vergrößerung und näht mit Fäden, die nur wenige Hundertstel Millimeter Durchmesser haben. Auch wenn oft behauptet wird, es seien Wunder, die Prof. Vajkoczy und sein Team vollbringen - es ist vor allem das routinierte Zusammenspiel von jahrelang geschulten Spezialisten, modernster Technologie und der Bereitschaft, auch neue Wege zu gehen, um Heilung möglich zu machen. Doch all dies ist keine Garantie, dass das gewünschte Ziel erreicht wird. Geht etwas schief, ist die Gefahr groß, dass Patienten nur mit schweren Behinderungen oder im schlimmsten Fall gar nicht überleben. Es ist ein schmaler Grat, auf dem Prof. Vajkoczy und sein Team unterwegs sind, und zwar immer, an jedem Tag, bei jeder Operation, selbst wenn sie noch so beherrschbar scheint. In aufrichtiger Offenheit erzählt Prof. Vajkoczy, wie er und sein Team mit dieser Herausforderung umgehen, wie schwierigste Operationen geplant und ausgeführt werden, was ihn als Neurochirurgen antreibt und was er fühlt, wenn er scheitert - und wenn sein Plan gelingt.Prof. Dr. Peter Vajkoczy, geboren 1968, ist seit 2007 Direktor der Klinik für Neurochirurgie an der Berliner Charité und gilt als einer der renommiertesten Neurochirurgen weltweit. Vajkoczy war Stipendiat der Studienstiftung des Deutschen Volkes und studierte in München. Bevor er nach Berlin wechselte, war er elf Jahre in Mannheim tätig, wo er sich auf die Neurochirurgie spezialisierte.
- Published
- 2022
79. Research from Charite University Hospital and School of Medicine Provide New Insights into Dendritic Cell Transplants (Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants)
- Subjects
Medical research ,Medicine, Experimental ,T cells -- Research ,Medical colleges -- Research ,Dendritic cells -- Research ,Skin -- Research ,Health - Abstract
2024 MAY 31 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on dendritic cell transplants have been published. According to news [...]
- Published
- 2024
80. Geschichten und Taten Wilwolts von Schaumberg : Kritische Edition
- Author
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Ludwig von Eyb der Jüngere and Ludwig von Eyb der Jüngere
- Subjects
- Knights and knighthood--Germany--Franconia--Biography, Nobility--Germany--Franconia--Biography
- Abstract
Bei den 1507 abgeschlossenen ‚Geschichten und Taten Wilwolts von Schaumberg‘, verfaßt von dem fränkischen Ritter Ludwig von Eyb d. J. unter aktiver Beteiligung seines Helden Wilwolt, handelt es sich um die mit Abstand qualitätsvollste deutsche (Auto-)Biographie eines Adeligen seiner Zeit – intendiert als Exempel für die jungen Standesgenossen. Die Jahre von 1468 bis 1505 umfassend wird in 4 Büchern, in anschaulicher Sprache und mit vielen kulturhistorischen Details, das facettenreiche Leben Wilwolts in Fürstendiensten auf europäischer Bühne entfaltet, seine adelige Erziehung, Aventüren und Turnierkämpfe, auch romantischer Minnedienst, v.a. aber seine herausragende Karriere als Landsknechtsführer und Diplomat. Buch 3 und 4 enthalten die beste deutsche Schilderung der weltgeschichtlichen Kämpfe in den Niederlanden im Zeitalter Maximilians I. Literarische Anspielungen dokumentieren Eybs umfassende Bildung; Illustrationen und ein Druck waren vorgesehen. Erstmals 1859 nach der damals einzig bekannten fehlerhaften Wolfenbütteler Handschrift in einem diplomatischen Abdruck von Adelbert von Keller publiziert war seit dem Nachweis des Nürnberger Originalmanuskripts eine Neuausgabe ein Desiderat. Die Edition bietet den kritischen Text mit inhaltlicher und sprachlicher Kommentierung, Karten, Stammtafeln, Abbildungen, Literaturhinweisen, Glossar und einer Einführung, die auch den biographischen Hintergrund der Autoren sowie Ludwig von Eybs weitere literarische Tätigkeit im Kontext der Zeit umfaßt. Randmarginalien erschließen den Text für den Leser.
- Published
- 2018
81. Charite University Hospital and School of Medicine Researchers Update Current Study Findings on Thrombocytopenia (Moderate LMWH Anticoagulation Improves Success Rate of Hind Limb Allotransplantation in Mice)
- Subjects
Thrombocytopenia -- Research -- Analysis ,Health - Abstract
2024 JAN 8 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- A new study on thrombocytopenia is now available. According to news originating from Berlin, Germany, [...]
- Published
- 2024
82. Research Results from University of Greifswald Update Knowledge of Science (Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models)
- Subjects
Optoelectronics industry ,Staphylococcus aureus ,Staphylococcus aureus infections ,Skin ,Physical fitness ,Health - Abstract
2022 MAR 12 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on science have been presented. According to news reporting originating [...]
- Published
- 2022
83. CNS myeloid cells critically regulate heat hyperalgesia
- Author
-
Kalin, Stefanie, Miller, Kelly R., Kalin, Roland E., Jendrach, Marina, Witzel, Christian, and Heppner, Frank L.
- Subjects
Microglia -- Research -- Physiological aspects ,Central nervous system -- Health aspects -- Research -- Physiological aspects ,Sensory disorders -- Care and treatment -- Research -- Genetic aspects ,Gene expression -- Research ,Health care industry - Abstract
Activation of non-neuronal microglia is thought to play a causal role in spinal processing of neuropathic pain. To specifically investigate microglia-mediated effects in a model of neuropathic pain and overcome the methodological limitations of previous approaches exploring microglia function upon nerve injury, we selectively ablated resident microglia by intracerebroventricular ganciclovir infusion into male CD11b-HSVTK-transgenic mice, which was followed by a rapid, complete, and persistent (23 weeks) repopulation of the CNS by peripheral myeloid cells. In repopulated mice that underwent sciatic nerve injury, we observed a normal response to mechanical stimuli, but an absence of thermal hypersensitivity ipsilateral to the injured nerve. Furthermore, we found that neuronal expression of calcitonin gene-related peptide (CGRP), which is a marker of neurons essential for heat responses, was diminished in the dorsal horn of the spinal cord in repopulated mice. These findings identify distinct mechanisms for heat and mechanical hypersensitivity and highlight a crucial contribution of CNS myeloid cells in the facilitation of noxious heat., Introduction Neuropathic pain refers to a complex chronic pain state resulting from damage to or dysfunction of the somatosensory system characterized by mechanical allodynia, hyperalgesia, and spontaneous pain in human [...]
- Published
- 2018
- Full Text
- View/download PDF
84. Die Ortsangaben im Buch Genesis : Ein historisch-topographischer und literarisch-topographischer Kommentar
- Author
-
Detlef Jericke and Detlef Jericke
- Subjects
- Bible. Genesis--Commentaries, Bible. Genesis--Geography, Bible. Genesis--Geography--Maps, Names, Geographical, Geography, Ancient, Geography, Ancient--Maps
- Abstract
Detlef Jericke kommentiert alle in der Genesis vorkommenden Ortsangaben nach der Reihenfolge ihres Auftretens. Zu jeder Ortsangabe werden Lokalisierungsvorschläge diskutiert, wobei, soweit möglich, ein Vorschlag näher begründet wird. Daneben steht die literarisch-topographische Auswertung, bei welcher erörtert wird, inwieweit die Verwendung der Toponyme den Sinngehalt der Erzählungen der Genesis mitgestaltet. Insofern lässt sich von einer'topographischen Inszenierung'der Texte sprechen. Dabei geht Jericke auch Fragen nach dem zeitgeschichtlichen Hintergrund einzelner Erzählabschnitte nach. 5 Karten veranschaulichen die Ergebnisse der topographischen Untersuchungen.
- Published
- 2013
85. Researcher from Charite - University Medicine Berlin Reports Recent Findings in Preeclampsia (Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy)
- Subjects
Preeclampsia -- Research ,Obstetrics -- Reports -- Research ,Health - Abstract
2023 JUL 10 (NewsRx) -- By a News Reporter-Staff News Editor at OBGYN & Reproduction Week -- Investigators publish new report on preeclampsia. According to news originating from Charite - [...]
- Published
- 2023
86. Präparierkurs : Präparieranweisungen und Theorie
- Author
-
Hans Maier, Andreas Winkelmann, Hans Maier, and Andreas Winkelmann
- Abstract
Dieses Buch ist zugleich Präparieranleitung und Kurzlehrbuch für den anatomischen Präparierkurs. Die im Kurs durchgeführten Präparierschritte werden im Detail beschrieben, mögliche Schwierigkeiten werden erläutert und auf gefährdete Strukturen in der unmittelbaren Nachbarschaft wird jeweils rechtzeitig hingewiesen. Eng damit verzahnt wird das erforderliche anatomische Wissen in einprägsamer und übersichtlicher Form dargestellt. Der Lernstoff ist nach der Wichtigkeit für die spätere ärztliche Tätigkeit ausgewählt und mit zahlreichen klinischen Hinweisen bereichert. Für Studierende der Medizin und Zahnmedizin ist das Buch eine ideale Präparier- und Lernhilfe. Auch Assistenten und studentische Tutoren finden hier alle nötigen Erläuterungen, um im Kurs selbstständig arbeiten zu können. Eine ausführliche Einführung in den Präparierkurs und hilfreiche Anhänge runden das Buch ab. Die 4. Auflage wurde vollständig neu überarbeitet. Dabei wurden auch mögliche unterschiedliche Vorgehensweisen bei der anatomischen Präparation berücksichtigt. Die 5. Auflage wurde nochmals aktualisiert.
- Published
- 2009
87. Findings from Christoph Andree and Co-Authors in the Area of Mastectomy Reported (The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate - Retrospective Single-centre 10-Year ...)
- Subjects
Breast reconstruction -- Methods -- Analysis ,Physical fitness -- Analysis -- Methods ,Health - Abstract
2020 JUL 11 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Surgery - Mastectomy have been published. According to [...]
- Published
- 2020
88. Charite - University Medicine Berlin Researchers Report on Findings in Liver Transplants (Over 30 Years of Pediatric Liver Transplantation at the Charite-Universitatsmedizin Berlin)
- Subjects
Medical research -- Analysis -- Reports ,Medicine, Experimental -- Analysis -- Reports ,Pediatrics -- Research -- Reports -- Analysis ,Liver -- Transplantation ,Health - Abstract
2022 MAR 18 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on liver transplants. According to news reporting out of [...]
- Published
- 2022
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