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Permanent pacemaker implantation in low birthweight (LBW) babies with congenital complete heart block is extremely challenging due to a paucity of appropriate pulse generator placement pocket sites. The development of infection following an implantation procedure can pose a life-threatening risk to the patients. With more patients in the younger group receiving these devices than ever before and the rate of infection increasing rapidly, a closer look at the burden of infection and its impact on outcome of these patients is warranted. We report mucormycosis infection at the abdominal pacemaker pocket site of an infant requiring pacemaker explantation and re-insertion into the intrapleural space. [ABSTRACT FROM AUTHOR]

Byline: Minati. Choudhury, Sandeep. Chauhan Sir, Saluja et al . encountered transesophageal echocardiography (TEE) probe malfunction in a patient who developed fever.[sup][1] The TEE probe stopped functioning when the TEE [...]

This preliminary study investigated the effect of a mandibular advancement device on upper airway collapsibility in seven patients with obstructive sleep apnea. Overnight polysomnography and dynamic magnetic resonance imaging were performed at the retropalatal and retroglossal levels, and the apnea-hypopnea Index (AHI), anteroposterior and lateral distances, and airway volumes were recorded. The tests were repeated following a 3-month period of wearing a customized mandibular advancement device. A significant reduction in AHI (from 31 events per hour to 18.2 events per hour) and improvement in airway dimension at both the retropalatal and retroglossal levels were recorded, suggesting a baseline record for future studies with a larger patient sample. [ABSTRACT FROM AUTHOR]

Byline: Minati. Choudhury, Madhur. Malik, Devagourou. Velayoudam Sir, Fatal anaphylaxis and biphasic reaction with the use of non-ionic contrast media is extremely rare, occur unexpectedly, and can be life-threatening. These [...]

Byline: Neeti. Makhija, Raveen. Singh, Usha. Kiran, Madhava. Kekani, Minati. Choudhury Patients with coexisting peripheral vascular disease and coronary artery disease constitute a high risk surgical group. Perioperative management of [...]

Byline: Sandeep. Khanna, Minati. Choudhury, Usha. Kiran The uncommon congenital cardiac anomaly, total anomalous pulmonary venous connection is incompatible with life unlessearly surgical intervention isdone. Most of the post operative [...]

Byline: Minati. Choudhury, Usha. Kiran The incidence of conjoined twin is rare and anaesthesia for procedures on conjoined twins is a demanding, exacting and meticulous exercise, whether prior to or [...]

Byline: Minati. Choudhury, Nirvik. Pal, Usha. Kiran Acute immune thrombocytopenic purpura in children, though a benign self limiting condition, at times complicated with life threatening haemorrhage. In spite of bleeding [...]

Background: The mechanism of development of atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG) has not been clearly defined, and the involvement of multiple factors such as advanced age, withdrawal of β-blockers, inadequate atrial protection, and electrolyte imbalance, particularly hypomagnesemia has been documented by several authors. Despite all the available pharmacologic prophylaxis, incidence of AF still remains high in this group of patients. This unexplained cause could be genetic inheritance of endothelin-1 (ET-1) gene which is thought to have a pro-arrhythmogenic effect.Aim: This study aims to investigate the relationship between plasma ET-1 concentrations, ET-1 gene polymorphisms in loci -1370 T/G, -134 (3A/4A) Ins/del, Lys198Asn (G/T), and occurrence of AF in patients undergoing CABG.Methodology: Ninety-eight nonrelated, nondiabetic patients over a period of 4 years undergoing routine CABG were selected for the present study. All patients were genotyped for three single nucleotide polymorphisms (SNPs) in loci -1370 T/G, -134 (3A/4A) Ins/del, and Lys198Asn (G/T) in the ET-1 gene by gene sequencing. The plasma ET-1 concentrations were measured using an ET immunoassay.Results: Plasma ET-1 concentrations were higher in AF+ group (P = 0.001) as compared to AF- group. The allele frequencies between AF+ and AF- group were significantly different only with respect to the Lys198Asn (G/T) SNP of the ET-1 gene.Conclusion: The study described the possible correlation of polymorphism of ET gene in CABG population from India. The ET-1 gene might play a disease-modifying role in atrial fibrillation. [ABSTRACT FROM AUTHOR]