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51. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Author

Keskin, Derin B., Anandappa, Annabelle J., Sun, Jing, Tirosh, Itay, Mathewson, Nathan D., Li, Shuqiang, Oliveira, Giacomo, Giobbie-Hurder, Anita, Felt, Kristen, Gjini, Evisa, Shukla, Sachet A., Hu, Zhuting, Li, Letitia, Le, Phuong M., Allesøe, Rosa L., Richman, Alyssa R., Kowalczyk, Monika S., Abdelrahman, Sara, Geduldig, Jack E., Charbonneau, Sarah, Pelton, Kristine, Iorgulescu, J. Bryan, Elagina, Liudmila, Zhang, Wandi, Olive, Oriol, McCluskey, Christine, Olsen, Lars R., Stevens, Jonathan, Lane, William J., Salazar, Andres M., Daley, Heather, Wen, Patrick Y., Chiocca, E. Antonio, Harden, Maegan, Lennon, Niall J., Gabriel, Stacey, Getz, Gad, Lander, Eric S., Regev, Aviv, Ritz, Jerome, Neuberg, Donna, Rodig, Scott J., Ligon, Keith L., Suvà, Mario L., Wucherpfennig, Kai W., Hacohen, Nir, Fritsch, Edward F., Livak, Kenneth J., Ott, Patrick A., Wu, Catherine J., and Reardon, David A.

Published
2019
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54. KLF4K409Q–mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment

Author

von Spreckelsen, Niklas, Waldt, Natalie, Poetschke, Rebecca, Kesseler, Christoph, Dohmen, Hildegard, Jiao, Hui-Ke, Nemeth, Attila, Schob, Stefan, Scherlach, Cordula, Sandalcioglu, Ibrahim Erol, Deckert, Martina, Angenstein, Frank, Krischek, Boris, Stavrinou, Pantelis, Timmer, Marco, Remke, Marc, Kirches, Elmar, Goldbrunner, Roland, Chiocca, E. Antonio, Huettelmaier, Stefan, Acker, Till, and Mawrin, Christian

Published
2020
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57. Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model.

Author

Iorgulescu, J. Bryan, Ruthen, Neil, Ryuhjin Ahn, Panagioti, Eleni, Gokhale, Prafulla C., Neagu, Martha, Speranza, Maria C., Eschle, Benjamin K., Soroko, Kara M., Piranlioglu, Raziye, Datta, Meenal, Krishnan, Shanmugarajan, Yates, Kathleen B., Baker, Gregory J., Jain, Rakesh K., Suvà, Mario L., Neuberg, Donna, White, Forest M., Chiocca, E. Antonio, and Freeman, Gordon J.

Subjects
ANTIGEN presentation, HUMAN biology, RAS oncogenes, IMMUNOTHERAPY, PROTEIN analysis
Abstract

Background: The GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct differences in their responses to immunotherapy. Methods: To decipher the cell-intrinsic mechanisms that drive immunotherapy resistance in CT2A-luc and to define the aspects of human cancer biology that these lines can best model, we systematically compared their characteristics using whole exome and transcriptome sequencing, and protein analysis through immunohistochemistry, Western blot, flow cytometry, immunopeptidomics, and phosphopeptidomics. Results: The transcriptional profiles of GL261-luc2 and CT2A-luc tumors resembled those of some huGBMs, despite neither line sharing the essential genetic or histologic features of huGBM. Both models exhibited striking hypermutation, with clonal hotspot mutations in RAS genes (Kras p.G12C in GL261-luc2 and Nras p.Q61L in CT2A-luc). CT2A-luc distinctly displayed mesenchymal differentiation, upregulated angiogenesis, and multiple defects in antigen presentation machinery (e.g. Tap1 p.Y488C and Psmb8 p.A275P mutations) and interferon response pathways (e.g. copy number losses of loci including IFN genes and reduced phosphorylation of JAK/STAT pathway members). The defect in MHC class I expression could be overcome in CT2Aluc by interferon-g treatment, which may underlie the modest efficacy of some immunotherapy combinations. Additionally, CT2A-luc demonstrated substantial baseline secretion of the CCL-2, CCL-5, and CCL-22 chemokines, which play important roles as myeloid chemoattractants. Conclusion: Although the clinical contexts that can be modeled by GL261 and CT2A for huGBM are limited, CT2A may be an informative model of immunotherapy resistance due to its deficits in antigen presentation machinery and interferon response pathways. [ABSTRACT FROM AUTHOR]

Published
2024
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71. Abstract 2990: Antigen presentation deficiency and mesenchymal differentiation underlie resistance to immunotherapy in the murine syngeneic CT2A tumor model

Author

Iorgulescu, Bryan, primary, Ruthen, Neil, additional, Ahn, Ryuhjin, additional, Panagioti, Eleni, additional, Gokhale, Prafulla, additional, Neagu, Martha, additional, Speranza, Maria, additional, Eschle, Benjamin, additional, Soroko, Kara, additional, Piranlioglu, Raziye, additional, Datta, Meenal, additional, Krishnan, Shanmugarajan, additional, Yates, Kathleen, additional, Baker, Gregory, additional, Jain, Rakesh, additional, Suva, Mario, additional, Neuberg, Donna, additional, White, Forest, additional, Chiocca, E., additional, Freeman, Gordon, additional, Sharpe, Arlene, additional, Wu, Catherine, additional, and Reardon, David, additional

Published
2023
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72. PPRX-1701, a nanoparticle formulation of 6′-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models

Author

Zdioruk, Mykola, primary, Jimenez-Macias, Jorge-Luis, additional, Nowicki, Michal Oskar, additional, Manz, Katherine E., additional, Pennell, Kurt D., additional, Koch, Marilin S., additional, Finkelberg, Tomer, additional, Wu, Bin, additional, Boucher, Paul, additional, Takeda, Yuji, additional, Li, Weiyi, additional, Piranlioglu, Raziye, additional, Ling, Alexander L., additional, Chiocca, E. Antonio, additional, and Lawler, Sean E., additional

Published
2023
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73. Supplementary Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Author

Otani, Yoshihiro, primary, Yoo, Ji Young, primary, Lewis, Cole T., primary, Chao, Samantha, primary, Swanner, Jessica, primary, Shimizu, Toshihiko, primary, Kang, Jin Muk, primary, Murphy, Sara A., primary, Rivera-Caraballo, Kimberly, primary, Hong, Bangxing, primary, Glorioso, Joseph C., primary, Nakashima, Hiroshi, primary, Lawler, Sean E., primary, Banasavadi-Siddegowda, Yeshavanth, primary, Heiss, John D., primary, Yan, Yuanqing, primary, Pei, Guangsheng, primary, Caligiuri, Michael A., primary, Zhao, Zhongming, primary, Chiocca, E. Antonio, primary, Yu, Jianhua, primary, and Kaur, Balveen, primary

Published
2023
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74. Figure S2 from Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

Author

Iorgulescu, J. Bryan, primary, Gokhale, Prafulla C., primary, Speranza, Maria C., primary, Eschle, Benjamin K., primary, Poitras, Michael J., primary, Wilkens, Margaret K., primary, Soroko, Kara M., primary, Chhoeu, Chhayheng, primary, Knott, Aine, primary, Gao, Yan, primary, Lim-Fat, Mary Jane, primary, Baker, Gregory J., primary, Bonal, Dennis M., primary, Nguyen, Quang-Dé, primary, Grant, Gareth R. L., primary, Ligon, Keith L., primary, Sorger, Peter K., primary, Chiocca, E. Antonio, primary, Anderson, Ana C., primary, Kirschmeier, Paul T., primary, Sharpe, Arlene H., primary, Freeman, Gordon J., primary, and Reardon, David A., primary

Published
2023
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76. Supplementary Figure from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Author

Otani, Yoshihiro, primary, Yoo, Ji Young, primary, Lewis, Cole T., primary, Chao, Samantha, primary, Swanner, Jessica, primary, Shimizu, Toshihiko, primary, Kang, Jin Muk, primary, Murphy, Sara A., primary, Rivera-Caraballo, Kimberly, primary, Hong, Bangxing, primary, Glorioso, Joseph C., primary, Nakashima, Hiroshi, primary, Lawler, Sean E., primary, Banasavadi-Siddegowda, Yeshavanth, primary, Heiss, John D., primary, Yan, Yuanqing, primary, Pei, Guangsheng, primary, Caligiuri, Michael A., primary, Zhao, Zhongming, primary, Chiocca, E. Antonio, primary, Yu, Jianhua, primary, and Kaur, Balveen, primary

Published
2023
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77. Supplementary Figures and Tables from Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma

Author

Nakashima, Hiroshi, primary, Nguyen, Tran, primary, Kasai, Kazue, primary, Passaro, Carmela, primary, Ito, Hirotaka, primary, Goins, William F., primary, Shaikh, Imran, primary, Erdelyi, Ronald, primary, Nishihara, Reiko, primary, Nakano, Ichiro, primary, Reardon, David A., primary, Anderson, Ana C., primary, Kuchroo, Vijay, primary, and Chiocca, E. Antonio, primary

Published
2023
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82. Table S1 from Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

Author

Iorgulescu, J. Bryan, primary, Gokhale, Prafulla C., primary, Speranza, Maria C., primary, Eschle, Benjamin K., primary, Poitras, Michael J., primary, Wilkens, Margaret K., primary, Soroko, Kara M., primary, Chhoeu, Chhayheng, primary, Knott, Aine, primary, Gao, Yan, primary, Lim-Fat, Mary Jane, primary, Baker, Gregory J., primary, Bonal, Dennis M., primary, Nguyen, Quang-Dé, primary, Grant, Gareth R. L., primary, Ligon, Keith L., primary, Sorger, Peter K., primary, Chiocca, E. Antonio, primary, Anderson, Ana C., primary, Kirschmeier, Paul T., primary, Sharpe, Arlene H., primary, Freeman, Gordon J., primary, and Reardon, David A., primary

Published
2023
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83. Data from NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

Author

Otani, Yoshihiro, primary, Yoo, Ji Young, primary, Lewis, Cole T., primary, Chao, Samantha, primary, Swanner, Jessica, primary, Shimizu, Toshihiko, primary, Kang, Jin Muk, primary, Murphy, Sara A., primary, Rivera-Caraballo, Kimberly, primary, Hong, Bangxing, primary, Glorioso, Joseph C., primary, Nakashima, Hiroshi, primary, Lawler, Sean E., primary, Banasavadi-Siddegowda, Yeshavanth, primary, Heiss, John D., primary, Yan, Yuanqing, primary, Pei, Guangsheng, primary, Caligiuri, Michael A., primary, Zhao, Zhongming, primary, Chiocca, E. Antonio, primary, Yu, Jianhua, primary, and Kaur, Balveen, primary

Published
2023
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84. Supplementary Figure 4 from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV

Author

Yoo, Ji Young, primary, Pradarelli, Jason, primary, Haseley, Amy, primary, Wojton, Jeffrey, primary, Kaka, Azeem, primary, Bratasz, Anna, primary, Alvarez-Breckenridge, Christopher A., primary, Yu, Jun-Ge, primary, Powell, Kimerly, primary, Mazar, Andrew P., primary, Teknos, Theodoros N., primary, Chiocca, E. Antonio, primary, Glorioso, Joseph C., primary, Old, Matthew, primary, and Kaur, Balveen, primary

Published
2023
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87. Supplementary Figure 2 from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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88. Supplementary Data from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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89. Supplementary Figure 5 from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV

Author

Yoo, Ji Young, primary, Pradarelli, Jason, primary, Haseley, Amy, primary, Wojton, Jeffrey, primary, Kaka, Azeem, primary, Bratasz, Anna, primary, Alvarez-Breckenridge, Christopher A., primary, Yu, Jun-Ge, primary, Powell, Kimerly, primary, Mazar, Andrew P., primary, Teknos, Theodoros N., primary, Chiocca, E. Antonio, primary, Glorioso, Joseph C., primary, Old, Matthew, primary, and Kaur, Balveen, primary

Published
2023
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90. Supplementary Table 1 from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV

Author

Yoo, Ji Young, primary, Pradarelli, Jason, primary, Haseley, Amy, primary, Wojton, Jeffrey, primary, Kaka, Azeem, primary, Bratasz, Anna, primary, Alvarez-Breckenridge, Christopher A., primary, Yu, Jun-Ge, primary, Powell, Kimerly, primary, Mazar, Andrew P., primary, Teknos, Theodoros N., primary, Chiocca, E. Antonio, primary, Glorioso, Joseph C., primary, Old, Matthew, primary, and Kaur, Balveen, primary

Published
2023
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91. Supplementary Methods and Legends from Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

Author

Iorgulescu, J. Bryan, primary, Gokhale, Prafulla C., primary, Speranza, Maria C., primary, Eschle, Benjamin K., primary, Poitras, Michael J., primary, Wilkens, Margaret K., primary, Soroko, Kara M., primary, Chhoeu, Chhayheng, primary, Knott, Aine, primary, Gao, Yan, primary, Lim-Fat, Mary Jane, primary, Baker, Gregory J., primary, Bonal, Dennis M., primary, Nguyen, Quang-Dé, primary, Grant, Gareth R. L., primary, Ligon, Keith L., primary, Sorger, Peter K., primary, Chiocca, E. Antonio, primary, Anderson, Ana C., primary, Kirschmeier, Paul T., primary, Sharpe, Arlene H., primary, Freeman, Gordon J., primary, and Reardon, David A., primary

Published
2023
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92. Supplementary Figure 1 from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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94. Supplementary Figure 1 from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV

Author

Yoo, Ji Young, primary, Pradarelli, Jason, primary, Haseley, Amy, primary, Wojton, Jeffrey, primary, Kaka, Azeem, primary, Bratasz, Anna, primary, Alvarez-Breckenridge, Christopher A., primary, Yu, Jun-Ge, primary, Powell, Kimerly, primary, Mazar, Andrew P., primary, Teknos, Theodoros N., primary, Chiocca, E. Antonio, primary, Glorioso, Joseph C., primary, Old, Matthew, primary, and Kaur, Balveen, primary

Published
2023
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96. Supplementary Figure 3 from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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97. Supplementary Figure 2 from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV

Author

Yoo, Ji Young, primary, Pradarelli, Jason, primary, Haseley, Amy, primary, Wojton, Jeffrey, primary, Kaka, Azeem, primary, Bratasz, Anna, primary, Alvarez-Breckenridge, Christopher A., primary, Yu, Jun-Ge, primary, Powell, Kimerly, primary, Mazar, Andrew P., primary, Teknos, Theodoros N., primary, Chiocca, E. Antonio, primary, Glorioso, Joseph C., primary, Old, Matthew, primary, and Kaur, Balveen, primary

Published
2023
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98. Supplementary Figure Legend from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV

Author

Yoo, Ji Young, primary, Pradarelli, Jason, primary, Haseley, Amy, primary, Wojton, Jeffrey, primary, Kaka, Azeem, primary, Bratasz, Anna, primary, Alvarez-Breckenridge, Christopher A., primary, Yu, Jun-Ge, primary, Powell, Kimerly, primary, Mazar, Andrew P., primary, Teknos, Theodoros N., primary, Chiocca, E. Antonio, primary, Glorioso, Joseph C., primary, Old, Matthew, primary, and Kaur, Balveen, primary

Published
2023
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99. Supplementary Figure 3 from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV

Author

Yoo, Ji Young, primary, Pradarelli, Jason, primary, Haseley, Amy, primary, Wojton, Jeffrey, primary, Kaka, Azeem, primary, Bratasz, Anna, primary, Alvarez-Breckenridge, Christopher A., primary, Yu, Jun-Ge, primary, Powell, Kimerly, primary, Mazar, Andrew P., primary, Teknos, Theodoros N., primary, Chiocca, E. Antonio, primary, Glorioso, Joseph C., primary, Old, Matthew, primary, and Kaur, Balveen, primary

Published
2023
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