51. Intravenous bisphosphonate-related osteonecrosis of the jaw: long-term follow-up of 109 patients
- Author
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T. Williams, Cherry L. Estilo, Joseph M. Huryn, Jerry Halpern, Joanne F. Chou, Amber L. Watters, Steven J. Tunick, Elyn Riedel, George C. Bohle, and Heidi J. Hansen
- Subjects
Adult ,Male ,medicine.medical_specialty ,Long term follow up ,medicine.medical_treatment ,Pamidronate ,Comorbidity ,Gastroenterology ,Zoledronic Acid ,Pathology and Forensic Medicine ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Diabetes Mellitus ,Humans ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Aged ,Aged, 80 and over ,Chi-Square Distribution ,Diphosphonates ,business.industry ,DMF Index ,Significant difference ,Smoking ,Clinical course ,Imidazoles ,Cancer ,Bisphosphonate ,Middle Aged ,medicine.disease ,Surgery ,Zoledronic acid ,Disease Progression ,Bisphosphonate-Associated Osteonecrosis of the Jaw ,Female ,New York City ,Oral Surgery ,business ,Osteonecrosis of the jaw ,medicine.drug ,Follow-Up Studies - Abstract
Objective We report long-term follow-up of patients with intravenous bisphosphonate–related osteonecrosis of the jaw (BRONJ). Study Design Medical and dental histories, including type and duration of bisphosphonate treatment and comorbidities, were analyzed and compared with clinical course of 109 patients with BRONJ at Memorial Sloan-Kettering Cancer Center Dental Service. Results Median onset of BRONJ in months was 21 (zoledronic acid), 30 (pamidronate), and 36 (pamidronate plus zoledronic acid), with a significant difference between the pamidronate plus zoledronic acid and zoledronic acid groups (P = .01; Kruskal-Wallis). The median number of doses for BRONJ onset was significantly less with zoledronic acid (n = 18) than pamidronte plus zoledronic acid (n = 36; P = .001), but not pamidronate alone (n = 29). An association between diabetes (P = .05), decayed-missing-filled teeth (P = .02), and smoking (P = .03) and progression of BRONJ was identified through χ2 test. Conclusions This long-term follow-up of BRONJ cases enhances the literature and contributes to the knowledge of BRONJ clinical course.
- Published
- 2011