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336 results on '"Chen, Ying-Yi"'

59. Prognostic factors associated with 18FDG-PET/CT in esophageal squamous cell carcinoma after trimodality treatment.

Author

Feng, Wei-Hsiang, Chen, Ying-Yi, Kuo, Yen‐Shou, Lin, Kuan-Hsun, Tsai, Yuan-Ming, Wu, Ti-Hui, Huang, Hsu-Kai, Huang, Tsai-Wang, and Kuo, Yen-Shou

Subjects
*SQUAMOUS cell carcinoma, *PROGNOSIS, *PROPORTIONAL hazards models, *PROGRESSION-free survival, *OVERALL survival
Abstract

Purpose: This study aimed to determine the pathological complete response (pCR), overall survival (OS), and disease-free survival (DFS) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) using post-neoadjuvant chemoradiotherapy (nCRT) F-18-fluorodeoxyglucose (18FDG).Methods: This is a retrospective study of patients with locally advanced ESCC receiving nCRT and then esophagectomy between January 2011 and December 2018 in the Tri-Service General Hospital, Taipei, Taiwan. A total of 50 patients were enrolled in the study. Survival analysis was performed using the Kaplan-Meier method and Cox proportional hazards model. Univariate and multivariate analysis were used to determine the independent prognostic factors.Results: Fifty patients were enrolled in the study, and 18 had pathological complete response. Post-nCRT SUVmax ≥ 3 is a poor prognostic factor associated with overall survival (HR: 3.665, P = 0.013) and disease-free survival (HR: 3.417, P = 0.011). Poor prognosis was found in the non-pCR plus post-nCRT SUVmax ≥ 3 group compared with pCR plus post-nCRT SUVmax < 3 group.Conclusions: SUVmax ≥ 3 is a poor prognostic factor in esophageal squamous cell carcinoma after trimodality treatment, even in patients having pathological complete response. [ABSTRACT FROM AUTHOR]

Published
2022
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67. miR‐124‐3p increases in high glucose induced osteocyte‐derived exosomes and regulates galectin‐3 expression: A possible mechanism in bone remodeling alteration in diabetic periodontitis

Author

Li, Jun, primary, Guo, Yue, additional, Chen, Ying‐Yi, additional, Liu, Qiong, additional, Chen, Yun, additional, Tan, Li, additional, Zhang, Shao‐Hui, additional, Gao, Zheng‐Rong, additional, Zhou, Ying‐Hui, additional, Zhang, Gui‐Ying, additional, and Feng, Yun‐Zhi, additional

Published
2020
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73. Levonorgestrel intrauterine system for the treatment of intermenstrual spotting in patients with previous cesarean delivery scar defect.

Author

Ou, Yu‐Che, Chen, Ying‐Yi, Lan, Kuo‐Chung, Tsai, Ching‐Chang, Chu, Li‐Ching, and Cheng, Ling‐Yun

Subjects
*STATISTICS, *ACQUISITION of data methodology, *SCARS, *INTRAUTERINE contraceptives, *RETROSPECTIVE studies, *MENSTRUATION, *SURGERY, *PATIENTS, *AMENORRHEA, *LEVONORGESTREL, *METRORRHAGIA, *DESCRIPTIVE statistics, *MEDICAL records, *CESAREAN section, *ADVERSE health care events, *DATA analysis, *DATA analysis software, *LONGITUDINAL method, *DISEASE complications
Abstract

Aim: To evaluate the efficacy of levonorgestrel 52 mg intrauterine system for intermenstrual bleeding in patients with previous cesarean delivery scar defects (PCDSs). Methods: The medical records of 28 consecutive patients with previous cesarean delivery scar defect and intermenstrual bleeding who had undergone conservative treatment with levonorgestrel 52 mg intrauterine system were reviewed. The efficacy of treatment and frequency of adverse events were measured retrospectively. Results: After 1 year of treatment, 22 patients (78.6%) reported an improvement in symptoms. The mean duration of menstruation were 18 and 5 days before and after treatment, respectively. No uterine perforations or pelvic inflammatory diseases occurred during or after the insertion procedures. Eighteen (64.3%) patients did not experience any adverse events, and the patients with adverse events reported that they could be managed by adjusting their medications or observation. Conclusion: Levonorgestrel intrauterine system may have a role in the safe and effective management of intermenstrual spotting in patients with PCDSs. [ABSTRACT FROM AUTHOR]

Published
2022
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74. A Chinese herbal formula 'Gan-Lu-Yin' suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways

Author

Chien Yi-Chung, Sheu Ming-Jyh, Wu Chieh-Hsi, Lin Wen-Hsin, Chen Ying-Yi, Cheng Po-Liang, and Cheng Hsu-Chen

Subjects
Chinese herbs, Gan-Lu-Yin, Migration, Restenosis, Vascular smooth muscle cell, Other systems of medicine, RZ201-999
Abstract

Abstract Background This study was to explore the effects of Gan-Lu-Yin (GLY) on the migration of vascular smooth muscle cells (VSMCs) induced by fetal bovine serum and on neointima formation in a rat model of carotid artery balloon injury. Methods VSMCs were treated with different concentrations of GLY, and then analyzed with Flow cytometric analysis, zymography, transwell, and western blotting. SD rats received balloon-injury were analyzed with H&E staining. Results Our results showed that GLY significantly decreased the thickness of neointima. The inhibition by non-cytoxic doses of GLY of VSMCs migration was through its negative regulatory effects on phosphorylated ERK1/2, PI3K/AKT, and FAK. The data showed that GLY can inhibit the migration of VSMCs cells, and might block injury-induced neointima hyperplasia via the inhibition of VSMCs migration, without inducing apoptosis. Conclusions These observations provide a mechanism of GLY in attenuating cell migration, thus as a potential intervention for restenosis.

Published
2012
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86. Optimal delivery of follow-up care following pulmonary lobectomy for lung cancer

Author

Lee, Shih-Chun, Chen,Ying-Yi, Huang,Tsai-Wang, and Chang,Hung

Subjects
Targets and Therapy [Lung Cancer]
Abstract

Ying-Yi Chen, Tsai-Wang Huang, Hung Chang, Shih-Chun LeeDivision of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Introduction: The rationale for oncologic surveillance following pulmonary lobectomy is to detect recurrent disease or a second primary lung cancer early enough so that an intervention can increase survival and/or improve quality of life. Therefore, we reviewed literature for international guidelines and reorganized these useful factors associated with non-small-cell lung cancer (NSCLC) recurrence as remedies in postoperative follow-up. Method: The population of interest for this review was patients who had been treated with complete resection for primary NSCLC and were in follow-up. Result: Guidelines on follow-up care for NSCLC vary internationally. Because of the production of progressive medical modalities, the current follow-up care should be corrected. Conclusion: The specific follow-up schedule for computed tomography imaging may be more or less frequent, depending upon risk factors for recurrence. Many different predictors of postoperative recurrence may help to optimize the patient selection for specified surveillance guidelines and personalized adjuvant therapies to prevent possibly occult micrometastases and to get a better outcome. Keywords: lung cancer, follow-up, surveillance, recurrence

Published
2016

90. Optimal delivery of follow-up care following pulmonary lobectomy for lung cancer

Author

Chen,Ying-Yi, Huang,Tsai-Wang, Chang,Hung, Lee,Shih-Chun, Chen,Ying-Yi, Huang,Tsai-Wang, Chang,Hung, and Lee,Shih-Chun

Abstract

Ying-Yi Chen, Tsai-Wang Huang, Hung Chang, Shih-Chun LeeDivision of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Introduction: The rationale for oncologic surveillance following pulmonary lobectomy is to detect recurrent disease or a second primary lung cancer early enough so that an intervention can increase survival and/or improve quality of life. Therefore, we reviewed literature for international guidelines and reorganized these useful factors associated with non-small-cell lung cancer (NSCLC) recurrence as remedies in postoperative follow-up. Method: The population of interest for this review was patients who had been treated with complete resection for primary NSCLC and were in follow-up. Result: Guidelines on follow-up care for NSCLC vary internationally. Because of the production of progressive medical modalities, the current follow-up care should be corrected. Conclusion: The specific follow-up schedule for computed tomography imaging may be more or less frequent, depending upon risk factors for recurrence. Many different predictors of postoperative recurrence may help to optimize the patient selection for specified surveillance guidelines and personalized adjuvant therapies to prevent possibly occult micrometastases and to get a better outcome. Keywords: lung cancer, follow-up, surveillance, recurrence

Published
2016

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