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Your search keyword '"Chen, Guan-Yuan"' showing total 69 results
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69 results on '"Chen, Guan-Yuan"'

55. Clinical manifestation and quantitative urinary analysis of N-ethylnorpentylone abuse in patients to the emergency department.

Author

Ling, Dean-An, Weng, Te-I, Chen, Ju-Yu, Chen, Guan-yuan, Hwa, Hsaio-Lin, and Fang, Cheng-Chung

Subjects
HOSPITAL emergency services, QUANTITATIVE research, SUBSTANCE-induced disorders, CREATININE, CALCULI, EMERGENCY medical services
Abstract

To the Editor, New psychoactive substances (NPSs) are evolving rapidly. Costa et al. described six patients reported to poison control centers in Brazil with N-ethylnorpentylone intoxication with detailed clinical assessments and toxicological analysis [[6]]. [Extracted from the article]

Published
2020
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68. [Latest Findings on the Interaction Mechanism Between Depressive Disorder and Intestinal Permeability].

Author

Zhang ZH, Xu DY, Chen GY, Teng T, Wu HY, and Zhou XY

Subjects
Humans, Pituitary-Adrenal System, Intestines microbiology, Permeability, Intestinal Mucosa metabolism, Intestinal Mucosa microbiology, Intestinal Mucosa pathology, Hypothalamo-Hypophyseal System, Depressive Disorder metabolism, Depressive Disorder pathology
Abstract

The intestinal barrier, a complex structure consisting of multiple layers of defense barriers, blocks the transfer of intestinal and foreign bacteria and their metabolites into the internal environment of the human body. Intestinal permeability can be used to evaluate the integrity of the intestinal barrier. Increased intestinal permeability has been observed in patients with depressive disorder. Some studies have reported an interaction between depressive disorder and intestinal barrier. Herein, we reviewed reported findings on the mechanisms of how systematic low-grade inflammation, vagal nerve dysfunction, and hypothalamic-pituitary-adrenal axis dysfunction cause changes in intestinal permeability in patients with depressive disorder and the pathogenic mechanism of how bacterial translocation caused by damaged intestinal barrier leads to depressive disorder. In addition, the potential mechanisms of how antidepressants improve intestinal permeability and how probiotics improve depressive disorder have been discussed., (Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).)

Published
2023
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69. Quantification of Plasma Oxylipins Using Solid-Phase Extraction and Reversed-Phase Liquid Chromatography-Triple Quadrupole Mass Spectrometry.

Author

Chen GY and Zhang Q

Subjects
Chromatography, Liquid, Chromatography, Reverse-Phase, Data Analysis, Humans, Isomerism, Software, Solid Phase Extraction, Tandem Mass Spectrometry, Workflow, Lipidomics methods, Oxylipins analysis, Plasma chemistry
Abstract

Oxylipins are an important class of bioactive lipids derived from polyunsaturated fatty acids. They can be both pro- and anti-inflammatory and function as important mediators in various pathological conditions. However, comprehensive analysis of oxylipins still remains a challenge because of their low abundance in plasma and the dominance of structurally similar isomeric species. Herein, we describe a simple and rapid method to comprehensively analyze oxylipins in blood plasma, which utilizes solid-phase extraction in 96-well format for efficient sample cleanup. Separation and detection of more than 130 oxylipins is accomplished by liquid chromatography-tandem mass spectrometry with multiple reaction monitoring in negative-ion mode. The absolute concentrations of oxylipins in human plasma are determined using the calibration curves constructed from internal standards. Detailed methods and precautions are presented for a successful adoption of this method in analytical laboratory.

Published
2021
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