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52. Urban environment during early-life and blood pressure in children

Author

Warembourg, C., primary, Nieuwenhuijsen, M., additional, Ballester, F., additional, de Castro, M., additional, Chatzi, L., additional, Esplugues, A., additional, Heude, B., additional, Maitre, L., additional, McEachan, R., additional, Robinson, O., additional, Slama, R., additional, Sunyer, J., additional, Urquiza, J., additional, Wright, J., additional, Basagaña, X., additional, and Vrijheid, M., additional

Published
2020
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53. Prenatal and postnatal exposure to per- and polyfluoroalkyl substances (PFAS) and cardiometabolic profile in children from six European cohorts.

Author

Papadopoulou, E., primary, Stratakis, N., additional, Basagaña, X., additional, Casas, M., additional, Conti, D. V., additional, Fossati, S., additional, Gražulevičienė, R., additional, Haug, L. S., additional, Heude, B., additional, Maitre, L., additional, McEachan, R. R., additional, Robinson, O., additional, Roumeliotaki, T., additional, Slama, R., additional, Urquiza, J., additional, Vafeiadi, M., additional, Wright, J., additional, Vrijheid, M., additional, and Chatzi, L., additional

Published
2020
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59. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth A Systematic Review and Meta-analysis

Author

Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth, Korevaar TIM, Derakhshan A, Taylor PN, Meima M, Chen L, Bliddal S, Carty DM, Meems M, Vaidya B, Shields B, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan C, Boucai L, Vafeiadi M, Grineva EN, Tkachuck AS, Pop VJM, Vrijkotte TG, Guxens M, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Murcia M, Lu X, Mukhtar S, Delles C, Feldt-Rasmussen U, Nelson SM, Alexander EK, Chaker L, Männistö T, Walsh JP, Pearce EN, Steegers EAP, and Peeters RP

Abstract

IMPORTANCE Maternal hypothyroidism and hyperthyroidism are risk factors for preterm birth. Milder thyroid function test abnormalities and thyroid autoimmunity are more prevalent, but it remains controversial if these are associated with preterm birth. OBJECTIVE To study if maternal thyroid function test abnormalities and thyroid autoimmunity are risk factors for preterm birth. DATA SOURCES AND STUDY SELECTION Studies were identified through a search of the Ovid MEDLINE, EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials, and Google Scholar databases from inception to March 18, 2018, and by publishing open invitations in relevant journals. Data sets from published and unpublished prospective cohort studies with data on thyroid function tests (thyrotropin [often referred to as thyroid-stimulating hormone or TSH] and free thyroxine [FT4] concentrations) or thyroid peroxidase (TPO) antibody measurements and gestational age at birth were screened for eligibility by 2 independent reviewers. Studies in which participants received treatment based on abnormal thyroid function tests were excluded. DATA EXTRACTION AND SYNTHESIS The primary authors provided individual participant data that were analyzed using mixed-effects models. MAIN OUTCOMES AND MEASURES The primary outcome was preterm birth (

Published
2019

60. Is systemic lupus erythematosus different in urban versus rural living environment? Data from the Cretan Lupus Epidemiology and Surveillance Registry

Author

Gergianaki, I. Fanouriakis, A. Adamichou, C. Spyrou, G. Mihalopoulos, N. Kazadzis, S. Chatzi, L. Sidiropoulos, P. Boumpas, D.T. Bertsias, G.

Abstract

Background: Examining urban–rural differences can provide insights into susceptibility or modifying factors of complex diseases, yet limited data exist on systemic lupus erythematosus (SLE). Objective: To study SLE risk, manifestations and severity in relation to urban versus rural residence. Methodology: Cross-sectional analysis of the Crete Lupus Registry. Demographics, residency history and clinical data were obtained from interviews and medical records (N=399 patients). Patients with exclusively urban, rural or mixed urban/rural residence up to enrolment were compared. Results: The risk of SLE in urban versus rural areas was 2.08 (95% confidence interval: 1.66–2.61). Compared with rural, urban residence was associated with earlier (by almost seven years) disease diagnosis – despite comparable diagnostic delay – and lower female predominance (6.8:1 versus 15:1). Rural patients had fewer years of education and lower employment rates. Smoking was more frequent among urban, whereas pesticide use was increased among rural patients. A pattern of malar rash, photosensitivity, oral ulcers and arthritis was more prevalent in rural patients. Residence was not associated with organ damage although moderate/severe disease occurred more frequently among rural-living patients (multivariable adjusted odds ratio: 2.17, p=0.011). Conclusion: Our data suggest that the living environment may influence the risk, gender bias and phenotype of SLE, not fully accounted for by sociodemographic factors. © The Author(s) 2018.

Published
2019

61. Association of Exposure to Ambient Air Pollution with Thyroid Function during Pregnancy

Author

Ghassabian, A. Pierotti, L. Basterrechea, M. Chatzi, L. Estarlich, M. Fernández-Somoano, A. Fleisch, A.F. Gold, D.R. Julvez, J. Karakosta, P. Lertxundi, A. Lopez-Espinosa, M.-J. Mulder, T.A. Korevaar, T.I.M. Oken, E. Peeters, R.P. Rifas-Shiman, S. Stephanou, E. Tardón, A. Tiemeier, H. Vrijheid, M. Vrijkotte, T.G.M. Sunyer, J. Guxens, M.

Subjects
endocrine system
Abstract

Importance: Air pollutants interact with estrogen nuclear receptors, but their effect on thyroid signaling is less clear. Thyroid function is of particular importance for pregnant women because of the thyroid's role in fetal brain development. Objective: To determine the short-term association of exposure to air pollution in the first trimester with thyroid function throughout pregnancy. Design, Setting, and Participants: In this cohort study, 9931 pregnant women from 4 European cohorts (the Amsterdam Born Children and Their Development Study, the Generation R Study, Infancia y Medio Ambiente, and Rhea) and 1 US cohort (Project Viva) with data on air pollution exposure and thyroid function during pregnancy were included. The recruitment period for the Amsterdam Born Children and Their Development Study was January 2003 to March 2004; for Generation R, April 2002 to January 2006; for Infancia y Medio Ambiente, November 2003 to January 2008; for Rhea, February 2007 to February 2008; and for Project Viva, April 1999 to November 2002. Statistical analyses were conducted from January 2018 to April 2019. Main Outcomes and Measures: Residential air pollution concentrations (ie, nitrogen oxide and particulate matter [PM]) during the first trimester of pregnancy were estimated using land-use regression and satellite-derived aerosol optical depth models. Free thyroxine, thyrotropin, and thyroid peroxidase antibody levels were measured across gestation. Hypothyroxinemia was defined as free thyroxine below the fifth percentile of the cohort distribution with normal thyrotropin levels, following the American Thyroid Association guidelines. Results: Among 9931 participants, the mean (SD) age was 31.2 (4.8) years, 4853 (48.9%) had more than secondary educational levels, 5616 (56.6%) were nulliparous, 404 (4.2%) had hypothyroxinemia, and 506 (6.7%) tested positive for thyroid peroxidase antibodies. Concentrations of nitrogen dioxide and PM with an aerodynamic diameter of 2.5 μm or less (PM2.5) were lower and had less variation in women in the US cohort than those in European cohorts. No associations of nitrogen oxide with thyroid function were found. Higher exposures to PM2.5 were associated with higher odds of hypothyroxinemia in pregnant women (odds ratio per 5-μg/m3change, 1.21; 95% CI, 1.00-1.47). Although exposure to PM with an aerodynamic diameter of 10 μm or less was not significantly associated with hypothyroxinemia, the coefficient was similar to that for the association of PM2.5 with hypothyroxinemia (odds ratio per 10-μg/m3change, 1.18; 95% CI, 0.93-1.48). Absorbances of PM2.5 and PM with aerodynamic diameter from 2.5 to 10 μg and were not associated with hypothyroxinemia. There was substantial heterogeneity among cohorts with respect to thyroid peroxidase antibodies (P for heterogeneity

Published
2019

62. Cord Leptin is Associated with Neuropsychomotor Development in Childhood

Author

Karakosta, P. Margetaki, K. Fthenou, E. Kampouri, M. Kyriklaki, A. Koutra, K. Chalkiadaki, G. Roumeliotaki, T. Vafeiadi, M. Kogevinas, M. Mantzoros, C. Chatzi, L.

Abstract

Objective: Leptin is critical for central nervous system development and maturation. This study aimed to evaluate the potential regulatory role of cord leptin in the neuropsychomotor development of children ages 18 months to 6 years. Methods: This study included 424 children from a prospective mother-child cohort (Rhea Study; Crete, Greece) with available cord leptin levels and data on neurodevelopmental outcomes at 18 months (Bayley Scales of Infant and Toddler Development, Third Edition), 4 years (McCarthy Scales of Children's Abilities), and 6 years (Raven's Coloured Progressive Matrices and Trail Making Test). Multivariable linear regression models were used to explore the associations. Results: Each 10-ng/mL increase in the cord leptin level was associated with increased scores on the gross motor scale at 18 months (β coefficient: 3.8; 95% CI: 0.0-7.5), with decreased scores in the general cognitive performance (β coefficient: −3.0; 95% CI: −5.5 to −0.4), perceptual performance (β coefficient: −3.4; 95% CI: −6.0 to −9.9), working memory (β coefficient: −3.1; 95% CI: −5.7 to −0.4), executive function (β coefficient −3.1; 95% CI: −5.7 to −0.5), and functions of the posterior cortex (β coefficient: −2.7; 95% CI: −5.2 to −0.1) scales at 4 years, and with a 3.7-unit decrease in the Raven's Coloured Progressive Matrices score at 6 years (β coefficient: −3.7; 95% CI: −6.9 to −0.5). Conclusions: Increased cord leptin levels are associated with enhanced gross motor development at 18 months but decreased cognitive performance in early and middle childhood. © 2019 The Obesity Society

Published
2019

63. Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts

Author

Santos, S. Voerman, E. Amiano, P. Barros, H. Beilin, L.J. Bergström, A. Charles, M.-A. Chatzi, L. Chevrier, C. Chrousos, G.P. Corpeleijn, E. Costa, O. Costet, N. Crozier, S. Devereux, G. Doyon, M. Eggesbø, M. Fantini, M.P. Farchi, S. Forastiere, F. Georgiu, V. Godfrey, K.M. Gori, D. Grote, V. Hanke, W. Hertz-Picciotto, I. Heude, B. Hivert, M.-F. Hryhorczuk, D. Huang, R.-C. Inskip, H. Karvonen, A.M. Kenny, L.C. Koletzko, B. Küpers, L.K. Lagström, H. Lehmann, I. Magnus, P. Majewska, R. Mäkelä, J. Manios, Y. McAuliffe, F.M. McDonald, S.W. Mehegan, J. Melén, E. Mommers, M. Morgen, C.S. Moschonis, G. Murray, D. Ní Chaoimh, C. Nohr, E.A. Nybo Andersen, A.-M. Oken, E. Oostvogels, A.J.J.M. Pac, A. Papadopoulou, E. Pekkanen, J. Pizzi, C. Polanska, K. Porta, D. Richiardi, L. Rifas-Shiman, S.L. Roeleveld, N. Ronfani, L. Santos, A.C. Standl, M. Stigum, H. Stoltenberg, C. Thiering, E. Thijs, C. Torrent, M. Tough, S.C. Trnovec, T. Turner, S. van Gelder, M.M.H.J. van Rossem, L. von Berg, A. Vrijheid, M. Vrijkotte, T.G.M. West, J. Wijga, A.H. Wright, J. Zvinchuk, O. Sørensen, T.I.A. Lawlor, D.A. Gaillard, R. Jaddoe, V.W.V.

Abstract

Objective: To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design: Individual participant data meta-analysis of 39 cohorts. Setting: Europe, North America, and Oceania. Population: 265 270 births. Methods: Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures: Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results: Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31– 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions: Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. Tweetable abstract: Promoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications. © 2019 Royal College of Obstetricians and Gynaecologists

Published
2019

64. Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes

Author

LifeCycle Project-Maternal Obesity Childhood Outcomes Study Group Voerman, E. Santos, S. Inskip, H. Amiano, P. Barros, H. Charles, M.-A. Chatzi, L. Chrousos, G.P. Corpeleijn, E. Crozier, S. Doyon, M. Eggesbø, M. Fantini, M.P. Farchi, S. Forastiere, F. Georgiu, V. Gori, D. Hanke, W. Hertz-Picciotto, I. Heude, B. Hivert, M.-F. Hryhorczuk, D. Iñiguez, C. Karvonen, A.M. Küpers, L.K. Lagström, H. Lawlor, D.A. Lehmann, I. Magnus, P. Majewska, R. Mäkelä, J. Manios, Y. Mommers, M. Morgen, C.S. Moschonis, G. Nohr, E.A. Nybo Andersen, A.-M. Oken, E. Pac, A. Papadopoulou, E. Pekkanen, J. Pizzi, C. Polanska, K. Porta, D. Richiardi, L. Rifas-Shiman, S.L. Roeleveld, N. Ronfani, L. Santos, A.C. Standl, M. Stigum, H. Stoltenberg, C. Thiering, E. Thijs, C. Torrent, M. Trnovec, T. van Gelder, M.M.H.J. van Rossem, L. von Berg, A. Vrijheid, M. Wijga, A. Zvinchuk, O. Sørensen, T.I.A. Godfrey, K. Jaddoe, V.W.V. Gaillard, R.

Abstract

Importance: Both low and high gestational weight gain have been associated with adverse maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not well defined for all prepregnancy weight ranges. Objectives: To examine the association of ranges of gestational weight gain with risk of adverse maternal and infant outcomes and estimate optimal gestational weight gain ranges across prepregnancy body mass index categories. Design, Setting, and Participants: Individual participant-level meta-analysis using data from 196 670 participants within 25 cohort studies from Europe and North America (main study sample). Optimal gestational weight gain ranges were estimated for each prepregnancy body mass index (BMI) category by selecting the range of gestational weight gain that was associated with lower risk for any adverse outcome. Individual participant-level data from 3505 participants within 4 separate hospital-based cohorts were used as a validation sample. Data were collected between 1989 and 2015. The final date of follow-up was December 2015. Exposures: Gestational weight gain. Main Outcomes and Measures: The main outcome termed any adverse outcome was defined as the presence of 1 or more of the following outcomes: preeclampsia, gestational hypertension, gestational diabetes, cesarean delivery, preterm birth, and small or large size for gestational age at birth. Results: Of the 196 670 women (median age, 30.0 years [quartile 1 and 3, 27.0 and 33.0 years] and 40 937 were white) included in the main sample, 7809 (4.0%) were categorized at baseline as underweight (BMI

Published
2019

65. Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy

Author

Ghassabian, A. (Akhgar), Pierotti, L. (Livia), Basterrechea, M. (Mikel), Chatzi, L. (Leda), Estarlich, M. (Marisa), Fernández-Somoano, A. (Ana), Fleisch, A.F. (Abby F.), Gold, D.R. (Diane), Julvez, J. (Jordi), Karakosta, P. (Polyxeni), Lertxundi, A. (Aitana), Lopez-Espinosa, M.-J. (Maria-Jose), Mulder, T.A. (Tessa A.), Korevaar, T.I.M. (Tim), Oken, E. (Emily), Peeters, R.P. (Robin), Rifas-Shiman, S.L. (Sheryl), Stephanou, E.G. (Euripides), Tardón, A. (Adonina), Tiemeier, H.W. (Henning), Vrijheid, M. (Martine), Vrijkotte, T.G.M. (Tanja), Sunyer, J. (Jordi), Guxens Junyent, M. (Mònica), Ghassabian, A. (Akhgar), Pierotti, L. (Livia), Basterrechea, M. (Mikel), Chatzi, L. (Leda), Estarlich, M. (Marisa), Fernández-Somoano, A. (Ana), Fleisch, A.F. (Abby F.), Gold, D.R. (Diane), Julvez, J. (Jordi), Karakosta, P. (Polyxeni), Lertxundi, A. (Aitana), Lopez-Espinosa, M.-J. (Maria-Jose), Mulder, T.A. (Tessa A.), Korevaar, T.I.M. (Tim), Oken, E. (Emily), Peeters, R.P. (Robin), Rifas-Shiman, S.L. (Sheryl), Stephanou, E.G. (Euripides), Tardón, A. (Adonina), Tiemeier, H.W. (Henning), Vrijheid, M. (Martine), Vrijkotte, T.G.M. (Tanja), Sunyer, J. (Jordi), and Guxens Junyent, M. (Mònica)

Abstract

Importance: Air pollutants interact with estrogen nuclear receptors, but their effect on thyroid signaling is less clear. Thyroid function is of particular importance for pregnant women because of the thyroid's role in fetal brain development. Objective: To determine the short-term association of exposure to air pollution in the first trimester with thyroid function throughout pregnancy. Design, Setting, and Participants: In this cohort study, 9931 pregnant women from 4 European cohorts (the Amsterdam Born Children and Their Development Study, the Generation R Study, Infancia y Medio Ambiente, and Rhea) and 1 US cohort (Project Viva) with data on air pollution exposure and thyroid function during pregnancy were included. The recruitment period for the Amsterdam Born Children and Their Development Study was January 2003 to March 2004; for Generation R, April 2002 to January 2006; for Infancia y Medio Ambiente, November 2003 to January 2008; for Rhea, February 2007 to February 2008; and for Project Viva, April 1999 to November 2002. Statistical analyses were conducted from January 2018 to April 2019. Main Outcomes and Measures: Residential air pollution concentrations (ie, nitrogen oxide and particulate matter [PM]) during the first trimester of pregnancy were estimated using land-use regression and satellite-derived aerosol optical depth models. Free thyroxine, thyrotropin, and thyroid peroxidase antibody levels were measured across gestation. Hypothyroxinemia was defined as free thyroxine below the fifth percentile of the cohort distribution w

Published
2019
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66. Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts

Author

Santos, S., Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergstrom, A., Charles, M-A, Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbo, M., Fantini, M. P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K. M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M-F, Hryhorczuk, D., Huang, R-C, Inskip, H., Karvonen, A. M., Kenny, L. C., Koletzko, B., Kupers, L. K., Lagstrom, H., Lehmann, I., Magnus, P., Majewska, R., Makela, J., Manios, Y., McAuliffe, F. M., McDonald, S. W., Mehegan, J., Melen, E., Mommers, M., Morgen, C. S., Moschonis, G., Murray, D., Ni Chaoimh, C., Nohr, E. A., Andersen, A-M Nybo, Oken, E., Oostvogels, A. J. J. M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S. L., Roeleveld, N., Ronfani, L., Santos, A. C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S. C., Trnovec, T., Turner, S., van Gelder, M. M. H. J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T. G. M., West, J., Wijga, A. H., Wright, J., Zvinchuk, O., Sorensen, T. I. A., Lawlor, D. A., Gaillard, R., Jaddoe, V. W. V., Santos, S., Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergstrom, A., Charles, M-A, Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbo, M., Fantini, M. P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K. M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M-F, Hryhorczuk, D., Huang, R-C, Inskip, H., Karvonen, A. M., Kenny, L. C., Koletzko, B., Kupers, L. K., Lagstrom, H., Lehmann, I., Magnus, P., Majewska, R., Makela, J., Manios, Y., McAuliffe, F. M., McDonald, S. W., Mehegan, J., Melen, E., Mommers, M., Morgen, C. S., Moschonis, G., Murray, D., Ni Chaoimh, C., Nohr, E. A., Andersen, A-M Nybo, Oken, E., Oostvogels, A. J. J. M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S. L., Roeleveld, N., Ronfani, L., Santos, A. C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S. C., Trnovec, T., Turner, S., van Gelder, M. M. H. J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T. G. M., West, J., Wijga, A. H., Wright, J., Zvinchuk, O., Sorensen, T. I. A., Lawlor, D. A., Gaillard, R., and Jaddoe, V. W. V.

Abstract

Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.

Published
2019

67. Association of gestational weight gain with adverse maternal and infant outcomes

Author

Voerman, E., Santos, S., Inskip, H., Amiano, P., Barros, H., Charles, M.-A., Chatzi, L., Chrousos, G.P., Corpeleijn, E., Crozier, S., Doyon, M., Eggesbø, M., Fantini, M.P., Farchi, S., Forastiere, F., Georgiu, V., Gori, D., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M.-F., Hryhorczuk, D., Iniguez, C., Karvonen, A.M., Kupers, L.K., Lagström, H., Lawlor, D.A., Lehmann, Irina, Magnus, P., Majewska, R., Mäkelä, J., Manios, Y., Mommers, M., Morgen, C.S., Moschonis, G., Nohr, E.A., Nybo Andersen, A.-M., Oken, E., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S.-L., Roeleveld, N., Ronfani, L., Santos, A.C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Trnovec, T., van Gelder, M.M.H.J., van Rossem, L., von Berg, A., Vijheid, M., Wijga, A., Zvinchuk, O., Sørensen, T.I.A., Godfrey, K., Jaddoe, V.W.V., Gaillard, R., Voerman, E., Santos, S., Inskip, H., Amiano, P., Barros, H., Charles, M.-A., Chatzi, L., Chrousos, G.P., Corpeleijn, E., Crozier, S., Doyon, M., Eggesbø, M., Fantini, M.P., Farchi, S., Forastiere, F., Georgiu, V., Gori, D., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M.-F., Hryhorczuk, D., Iniguez, C., Karvonen, A.M., Kupers, L.K., Lagström, H., Lawlor, D.A., Lehmann, Irina, Magnus, P., Majewska, R., Mäkelä, J., Manios, Y., Mommers, M., Morgen, C.S., Moschonis, G., Nohr, E.A., Nybo Andersen, A.-M., Oken, E., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S.-L., Roeleveld, N., Ronfani, L., Santos, A.C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Trnovec, T., van Gelder, M.M.H.J., van Rossem, L., von Berg, A., Vijheid, M., Wijga, A., Zvinchuk, O., Sørensen, T.I.A., Godfrey, K., Jaddoe, V.W.V., and Gaillard, R.

Abstract

Importance  Both low and high gestational weight gain have been associated with adverse maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not well defined for all prepregnancy weight ranges.Objectives  To examine the association of ranges of gestational weight gain with risk of adverse maternal and infant outcomes and estimate optimal gestational weight gain ranges across prepregnancy body mass index categories.Design, Setting, and Participants  Individual participant-level meta-analysis using data from 196 670 participants within 25 cohort studies from Europe and North America (main study sample). Optimal gestational weight gain ranges were estimated for each prepregnancy body mass index (BMI) category by selecting the range of gestational weight gain that was associated with lower risk for any adverse outcome. Individual participant-level data from 3505 participants within 4 separate hospital-based cohorts were used as a validation sample. Data were collected between 1989 and 2015. The final date of follow-up was December 2015.Exposures  Gestational weight gain.Main Outcomes and Measures  The main outcome termed any adverse outcome was defined as the presence of 1 or more of the following outcomes: preeclampsia, gestational hypertension, gestational diabetes, cesarean delivery, preterm birth, and small or large size for gestational age at birth.Results  Of the 196 670 women (median age, 30.0 years [quartile 1 and 3, 27.0 and 33.0 years] and 40 937 were white) included in the main sample, 7809 (4.0%) were categorized at baseline as underweight (BMI <18.5); 133 788 (68.0%), normal weight (BMI, 18.5-24.9); 38 828 (19.7%), overweight (BMI, 25.0-29.9); 11 992 (6.1%), obesity grade 1 (BMI, 30.0-34.9); 3284 (1.7%), obesity grade 2 (BMI, 35.0-39.9); and 969 (0.5%), obesity grade 3 (BMI, ≥40.0). Overall, any adverse outcome occurred in 37.2% (n = 73 161) of women, ranging fro

Published
2019

68. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis

Author

Voerman, E., Santos, S., Patro Golab, B., Amiano, P., Ballester, F., Barros, H., Bergström, A., Charles, M.-A., Chatzi, L., Chevrier, C., Chrousos, G.P., Corpeleijn, E., Costet, N., Crozier, S., Devereux, G., Eggesbø, M., Ekström, S., Fantini, M.P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K.M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hryhorczuk, D., Huang, R.-C., Inskip, H., Iszatt, N., Karvonen, A.M., Kenny, L.C., Koletzko, B., Küpers, L.K., Lagström, H., Lehmann, Irina, Magnus, P., Majewska, R., Mäkelä, J., Manios, Y., McAuliffe, F.M., McDonald, S.W., Mehegan, J., Mommers, M., Morgen, C.S., Mori, T.A., Moschonis, G., Murray, D., Ní Chaoimh, C., Nohr, E.A., Nybo Andersen, A.-M., Oken, E., Oostvogels, A.J.J.M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S.-L., Ronfani, L., Santos, A.C., Standl, M., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S.C., Trnovec, T., Turner, S., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T.G.M., West, J., Wijga, A., Wright, J., Zvinchuk, O., Sørensen, T.I.A., Lawlor, D.A., Gaillard, R., Jaddoe, V.W.V., Voerman, E., Santos, S., Patro Golab, B., Amiano, P., Ballester, F., Barros, H., Bergström, A., Charles, M.-A., Chatzi, L., Chevrier, C., Chrousos, G.P., Corpeleijn, E., Costet, N., Crozier, S., Devereux, G., Eggesbø, M., Ekström, S., Fantini, M.P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K.M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hryhorczuk, D., Huang, R.-C., Inskip, H., Iszatt, N., Karvonen, A.M., Kenny, L.C., Koletzko, B., Küpers, L.K., Lagström, H., Lehmann, Irina, Magnus, P., Majewska, R., Mäkelä, J., Manios, Y., McAuliffe, F.M., McDonald, S.W., Mehegan, J., Mommers, M., Morgen, C.S., Mori, T.A., Moschonis, G., Murray, D., Ní Chaoimh, C., Nohr, E.A., Nybo Andersen, A.-M., Oken, E., Oostvogels, A.J.J.M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S.-L., Ronfani, L., Santos, A.C., Standl, M., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S.C., Trnovec, T., Turner, S., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T.G.M., West, J., Wijga, A., Wright, J., Zvinchuk, O., Sørensen, T.I.A., Lawlor, D.A., Gaillard, R., and Jaddoe, V.W.V.

Abstract

BackgroundMaternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Methods and findingsWe conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, North America, and Australia. We assessed the individual and combined associations of maternal pre-pregnancy BMI and gestational weight gain, both in clinical categories and across their full ranges, with the risks of overweight/obesity in early (2.0–5.0 years), mid (5.0–10.0 years) and late childhood (10.0–18.0 years), using multilevel binary logistic regression models with a random intercept at cohort level adjusted for maternal sociodemographic and lifestyle-related characteristics. We observed that higher maternal pre-pregnancy BMI and gestational weight gain both in clinical categories and across their full ranges were associated with higher risks of childhood overweight/obesity, with the strongest effects in late childhood (odds ratios [ORs] for overweight/obesity in early, mid, and late childhood, respectively: OR 1.66 [95% CI: 1.56, 1.78], OR 1.91 [95% CI: 1.85, 1.98], and OR 2.28 [95% CI: 2.08, 2.50] for maternal overweight; OR 2.43 [95% CI: 2.24, 2.64], OR 3.12 [95% CI: 2.98, 3.27], and OR 4.47 [95% CI: 3.99, 5.23] for maternal obesity; and OR 1.39 [95% CI: 1.30, 1.49], OR 1.55 [95% CI: 1.49, 1.60], and OR 1.72 [95% CI: 1.56, 1.91] for excessive gestational weight gain). The proportions of childhood overweight/obesity prevalence attributable to maternal overweight, maternal

Published
2019

69. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth:A Systematic Review and Meta-analysis

Author

Korevaar, Tim I.M., Derakhshan, Arash, Taylor, Peter N, Meima, Marcel, Chen, Liangmiao, Bliddal, Sofie, Carty, David M, Meems, Margreet, Vaidya, Bijay, Shields, Beverley, Ghafoor, Farkhanda, Popova, Polina V, Mosso, Lorena, Oken, Emily, Suvanto, Eila, Hisada, Aya, Yoshinaga, Jun, Brown, Suzanne J, Bassols, Judit, Auvinen, Juha, Bramer, Wichor M, López-Bermejo, Abel, Dayan, Colin, Boucai, Laura, Vafeiadi, Marina, Grineva, Elena N, Tkachuck, Alexandra S, Pop, Victor J M, Vrijkotte, T G, Guxens, M, Chatzi, L, Sunyer, J, Jiménez-Zabala, A, Riaño, I, Murcia, M, Lu, X, Mukhtar, S, Delles, C, Feldt-Rasmussen, U, Nelson, S M, Alexander, E K, Chaker, L, Männistö, T, Walsh, J P, Pearce, E N, Steegers, E A P, Peeters, R P, Korevaar, Tim I.M., Derakhshan, Arash, Taylor, Peter N, Meima, Marcel, Chen, Liangmiao, Bliddal, Sofie, Carty, David M, Meems, Margreet, Vaidya, Bijay, Shields, Beverley, Ghafoor, Farkhanda, Popova, Polina V, Mosso, Lorena, Oken, Emily, Suvanto, Eila, Hisada, Aya, Yoshinaga, Jun, Brown, Suzanne J, Bassols, Judit, Auvinen, Juha, Bramer, Wichor M, López-Bermejo, Abel, Dayan, Colin, Boucai, Laura, Vafeiadi, Marina, Grineva, Elena N, Tkachuck, Alexandra S, Pop, Victor J M, Vrijkotte, T G, Guxens, M, Chatzi, L, Sunyer, J, Jiménez-Zabala, A, Riaño, I, Murcia, M, Lu, X, Mukhtar, S, Delles, C, Feldt-Rasmussen, U, Nelson, S M, Alexander, E K, Chaker, L, Männistö, T, Walsh, J P, Pearce, E N, Steegers, E A P, and Peeters, R P

Abstract

Importance: Maternal hypothyroidism and hyperthyroidism are risk factors for preterm birth. Milder thyroid function test abnormalities and thyroid autoimmunity are more prevalent, but it remains controversial if these are associated with preterm birth.Objective: To study if maternal thyroid function test abnormalities and thyroid autoimmunity are risk factors for preterm birth.Data Sources and Study Selection: Studies were identified through a search of the Ovid MEDLINE, EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials, and Google Scholar databases from inception to March 18, 2018, and by publishing open invitations in relevant journals. Data sets from published and unpublished prospective cohort studies with data on thyroid function tests (thyrotropin [often referred to as thyroid-stimulating hormone or TSH] and free thyroxine [FT4] concentrations) or thyroid peroxidase (TPO) antibody measurements and gestational age at birth were screened for eligibility by 2 independent reviewers. Studies in which participants received treatment based on abnormal thyroid function tests were excluded.Data Extraction and Synthesis: The primary authors provided individual participant data that were analyzed using mixed-effects models.Main Outcomes and Measures: The primary outcome was preterm birth (<37 weeks' gestational age).Results: From 2526 published reports, 35 cohorts were invited to participate. After the addition of 5 unpublished data sets, a total of 19 cohorts were included. The study population included 47 045 pregnant women (mean age, 29 years; median gestational age at blood sampling, 12.9 weeks), of whom 1234 (3.1%) had subclinical hypothyroidism (increased thyrotropin concentration with normal FT4 concentration), 904 (2.2%) had isolated hypothyroxinemia (decreased FT4 concentration with normal thyrotropin concentration), and 3043 (7.5%) were TPO antibody positive; 2357 (5.0%) had a preterm birth. The

Published
2019

70. Impact of maternal body mass index and gestational weight gain on pregnancy complications:an individual participant data meta-analysis of European, North American and Australian cohorts

Author

Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergstrom, A., Charles, M-A, Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbo, M., Fantini, M. P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K. M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M-F, Hryhorczuk, D., Huang, R-C, Inskip, H., Karvonen, A. M., Kenny, L. C., Koletzko, B., Kupers, L. K., Lagstrom, H., Lehmann, I., Magnus, P., Majewska, R., Makela, J., Manios, Y., McAuliffe, F. M., McDonald, S. W., Mehegan, J., Melen, E., Mommers, M., Morgen, C. S., Moschonis, G., Murray, D., Ni Chaoimh, C., Nohr, E. A., Andersen, A-M Nybo, Oken, E., Oostvogels, A. J. J. M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S. L., Roeleveld, N., Ronfani, L., Santos, A. C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S. C., Trnovec, T., Turner, S., van Gelder, M. M. H. J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T. G. M., West, J., Wijga, A. H., Wright, J., Zvinchuk, O., Sørensen, T. I. A., Lawlor, D. A., Gaillard, R., Jaddoe, V. W. V., Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergstrom, A., Charles, M-A, Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbo, M., Fantini, M. P., Farchi, S., Forastiere, F., Georgiu, V., Godfrey, K. M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M-F, Hryhorczuk, D., Huang, R-C, Inskip, H., Karvonen, A. M., Kenny, L. C., Koletzko, B., Kupers, L. K., Lagstrom, H., Lehmann, I., Magnus, P., Majewska, R., Makela, J., Manios, Y., McAuliffe, F. M., McDonald, S. W., Mehegan, J., Melen, E., Mommers, M., Morgen, C. S., Moschonis, G., Murray, D., Ni Chaoimh, C., Nohr, E. A., Andersen, A-M Nybo, Oken, E., Oostvogels, A. J. J. M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S. L., Roeleveld, N., Ronfani, L., Santos, A. C., Standl, M., Stigum, H., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S. C., Trnovec, T., Turner, S., van Gelder, M. M. H. J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T. G. M., West, J., Wijga, A. H., Wright, J., Zvinchuk, O., Sørensen, T. I. A., Lawlor, D. A., Gaillard, R., and Jaddoe, V. W. V.

Published
2019

71. Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy

Author

Ghassabian, A, Pierotti, L, Basterrechea, M, Chatzi, L, Estarlich, M, Fernandez-Somoano, A, Fleisch, AF, Gold, DR, Julvez, J, Karakosta, P, Lertxundi, A, Lopez-Espinosa, MJ, Mulder, Tessa, Korevaar, Tim, Oken, E, Peeters, Robin, Rifas-Shiman, S, Stephanou, E, Tardon, A, Tiemeier, Henning, Vrijheid, M, Vrijkotte, TG, Sunyer, J, Guxens Junyent, Monica, Ghassabian, A, Pierotti, L, Basterrechea, M, Chatzi, L, Estarlich, M, Fernandez-Somoano, A, Fleisch, AF, Gold, DR, Julvez, J, Karakosta, P, Lertxundi, A, Lopez-Espinosa, MJ, Mulder, Tessa, Korevaar, Tim, Oken, E, Peeters, Robin, Rifas-Shiman, S, Stephanou, E, Tardon, A, Tiemeier, Henning, Vrijheid, M, Vrijkotte, TG, Sunyer, J, and Guxens Junyent, Monica

Published
2019

72. Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement

Author

Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal-Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V. J., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, Jean, ARIA and EPOS working groups, Akdis, M., Alobid, I., Ankri, J., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Asarnoj, A., Avolio, F., Baiardini, I., Barbagallo, Carlo M., Barbara, Cristina, Baroody, F., Bateman, E. D., Bedbrook, Anna, Beghé, B., Bel, E. H., Bennoor, K. S., Benson, M., Bergmann, K. C., Bewick, M., Białoszewski, A. Z., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Bucca, C., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Camargos, P. A. M., Camuzat, Thierry, Cardona, V., Carlsen, K. H., Carr, W., Carreiro-Martins, P., Carriazo, A. M., Casale, T. B., A.M, Cepeda Sarabia, Cervin, A., Cesari, M., Chatzi, L., Chavannes, Niels H., Chiron, R., Pérez, T. Chivato, Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cohen, N., Diaz, S. Conzález, Cox, L., Crooks, George, Cruz, A. A., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Keenoy, E. De Manuel, Sousa, J. Correia de, Vries, Elisabeth G. E. de, Dedeu, Antoni, Deleanu, D., Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H. B., Douglas, R., Dray, G., Toit, G. Du, Dubakiene, R., Durham, S. R., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink-Wagner, A., Fiocchi, A., Fletcher, M., Fonseca, J. A., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioǧlu, B., Georgalas, C., Gereda, J. E., Goossens, H., Grisle, I., Guldemond, N. A., Gutter, Z., Guzmán, M. A., Haahtela, T., Harvey, R., Heinrich, J., Hellquist-Dahl, B., Hopkins, C., Horak, F., Hourihane, J. O. B., Humbert, M., Hyland, M. E., Iaccarino, G., Illario, M., Jares, E. J., Jeandel, Claude, Johnston, S. L., Jonquet, Olivier, Jung, K. S., Just, J., Jutel, M., Kaidashev, I. P., Kalayci, O., Kalogjera, L., Kalyoncu, A. F., Kardas, P., Keil, T., Keith, P. K., Kerkhof, M., Kern, B., Kerstjens, H. A. M., Khaitov, M. R., Khaltaev, N., Klimek, L., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Larenas-Linnemann, D., Lau, S., Laune, D., Le, Tuyen D., Li, J., Lieberman, P., Lipworth, B. J., Carlsen, K. C. Lodrup, Louis, R., Lupinek, C., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P. J., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Mercier, Jacques, Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Almeida, M. Morais, Mosges, R., Mullol, J., Murray, R., Naclerio, R. N., Nadif, R., Namazova-Baranova, L., Neffen, H., Nekam, K., Nieto, A., Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Papi, A., Park, H. S., Passalacqua, G., Pawankar, R., Pedersen, S., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D. S., Potter, P., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Riechelmann, H., Robalo-Cordeiro, C., Roberts, G., Rodenas, F., Rodriguez-Mañas, L., Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rottem, M., Ryan, D., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schlosser, R., Schmid-Grendelmeier, P., Schunemann, H. J., Scichilone, N., Senior, B., Serrano, E., Sheikh, A., Shields, K. M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stellato, C., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, Jordi, Thijs, C., Thomas, M., Todo-Bom, A., Tomazic, P. V., Toskala, E., Triggiani, M., Valenta, R., Valero, A. L., Valiulis, A., Valovirta, E., Eerd, M. van, Ganse, E. van, Hage, M. van, Wick, R. G. van, Vandenplas, O., Varona, L. L., Vazankari, T., Vellas, B., Ventura, M. T., Vezzani, G., Viegi, Giovanni, Voegels, R., Vontetsianos, T., Wagenmann, M., Wahn, U., Walker, S., Wang, D. Y., Wang, Ya Xing, Werfel, T., Whalley, B., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wormald, P. J., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yorgancioglu, A., Young, I., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Adult Psychiatry, Ear, Nose and Throat, AII - Inflammatory diseases, AII - Amsterdam institute for Infection and Immunity, Pulmonology, Other departments, Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal-Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, J., Aberer, W., Akdis, M., Alobid, I., Ankri, J., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Asarnoj, A., Avolio, F., Baiardini, I., Barbagallo, M., Barbara, C., Baroody, F., Bateman, E. D., Bedbrook, A., Beghe, B., Bel, E. H., Bennoor, K. S., Benson, M., Bergmann, K. C., Bewick, M., Bialoszewski, A. Z., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Camargos, P. A., Camuzat, T., Cardona, V., Carlsen, K. H., Carr, W., Carreiro-Martins, P., Carriazo, A. M., Casale, T., Cepeda Sarabia, A. M., Cervin, A., Cesari, M., Chatzi, L., Chavannes, N. H., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciprandi, G., Cohen, N., Conzalez Diaz, S., Cox, L., Crooks, G., Cruz, A. A., Custovic, A., Dahl, R., Dahlen, S. E., Darsow, U., De Carlo, G., De Manuel Keenoy, E., de Sousa, J. C., De Vries, G., Dedeu, T., Deleanu, D., Demoly, P., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Douglas, R., Dray, G., Du Toit, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink Wagner, A., Fiocchi, A., Fletcher, M., Fonseca, J., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioglu, B., Georgalas, C., Gereda, J. E., Goossens, H., Grisle, I., Guldemond, N. A., Gutter, Z., Guzman, M. A., Haahtela, T., Harvey, R., Heinrich, J., Hellquist-Dahl, B., Hopkins, C., Horak, F., Hourihane, J. O., Humbert, M., Hyland, M., Iaccarino, G., Illario, M., Jares, E. J., Jeandel, C., Johnston, S. L., Jonquet, O., Jung, K. S., Just, J., Jutel, M., Kaidashev, I. P., Kalayci, O., Kalogjera, L., Kalyoncu, A. F., Kardas, P., Keil, T., Keith, P. K., Kerkhof, M., Kern, B., Kerstjens, H. A., Khaitov, M., Khaltaev, N., Klimek, L., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Larenas-Linnemann, D., Lau, S., Laune, D., Le, L. T., Li, J., Lieberman, P., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lund, V. J., Lupinek, C., Macnee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Mercier, J., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Morais-Almeida, M., Mosges, R., Mullol, J., Murray, R., Naclerio, R., Nadif, R., Namazova-Baranova, L., Neffen, H., Nekam, K., Nieto, A., Nogues, M., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P., Pali-Scholl, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Papi, A., Park, H. S., Passalacqua, G., Niggemann, B., Nogueira-Silva, L., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Riechelmann, H., Robalo-Cordeiro, C., Roberts, G., Rodenas, F., Rodriguez-Manas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schlosser, R., Schmid-Grendelmeier, P., Schunemann, H. J., Scichilone, N., Senior, B., Serrano, E., Sheikh, A., Shields, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stellato, C., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, J., Thijs, C., Thomas, M., Todo-Bom, A., Tomazic, P. V., Toskala, E., Triggiani, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hage, M., van Wick, R. G., Vandenplas, O., Varona, L. L., Vazankari, T., Vellas, B., Ventura, M. T., Vezzani, G., Viegi, G., Voegels, R., Vontetsianos, T., Wagenmann, M., Wahn, U., Walker, S., Wang, D. Y., Wang, Y., Werfel, T., Whalley, B., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wormald, P. J., Wright, J., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Young, I., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Asthma UK, Department of Dermatology, Allergology and Venereology, Clinicum, HUS Inflammation Center, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Hellings, P.W., Fokkens, W.J., Akdis, C.A., Canonica, G.W., Seys, S.F., Ansotegui, I.J., Anto, J.M., Bateman, E.D., Beghé, B., Bel, E.H., Bennoor, K.S., Bergmann, K.C., Bialoszewski, A.Z., Boner, A.L., Boulet, L.P., Bousquet, P.J., Briggs, A.H., Brightling, C.E., Caimmi, D.P., Calderon, M.A., Camargos, P.A., Carlsen, K.H., Carriazo, A.M., Cepeda Sarabia, A.M., Chavannes, N.H., Chuchalin, A.G., Chung, K.F., Conzález Diaz, S., Cruz, A.A., Dahlen, S.E., de Sousa, J.C., Denburg, J.A., Dinh-Xuan, A.T., Durham, S.R., Dykewicz, M.S., Gemicioğlu, B., Gereda, J.E., Guldemond, N.A., Guzmán, M.A., Hourihane, J.O., Jares, E.J., Johnston, S.L., Jung, K.S., Kaidashev, I., Kalyoncu, A.F., Keith, P.K., Kerstjens, H.A., Koppelman, G.H., Kowalski, M.L., Le, L.T., Lodrup Carlsen, K.C., Lund, V.J., MacNee, W., Marshall, G.D., Masjedi, M.R., Melén, E., Meltzer, E.O., Mösges, R., Nyembue, T.D., O'Hehir, R.E., Pali-Schöll, I., Papadopoulos, N.G., Park, H.S., Pawankar, R., Pedersen, S., Pereira, A.M., Popov, T.A., Poulsen, L.K., Rabe, K.F., Rodriguez-Mañas, L., Scadding, G.K., Schunemann, H.J., Simons, F.E.R., Sisul, J.C., Smit, H.A., Solé, D., Sterk, P.J., Tomazic, P.V., van Wick, R.G., Varona, L.L., Ventura, M.T., Wang, D.Y., Williams, D.M., Wormald, P.J., Yawn, B.P., Yiallouros, P.K., Yusuf, O.M., Zar, H.J., and Zernotti, M.E.

Subjects
allergic rhinitis, integrated care pathway, precision medicine, rhinosinusitis, Allergy, Rhinosinusitis, Disease, Allergic rhinitis, 0302 clinical medicine, QUALITY-OF-LIFE, Medicine, Immunology and Allergy, 030223 otorhinolaryngology, Sinusitis, NASAL POLYPOSIS, Rhinitis, Precision medicine, 3. Good health, Algorithm, REAL-LIFE, IMPACT OUTCOMES, ARIA and EPOS working groups, 1107 Immunology, DISEASES, GA(2)LEN, Disease Progression, allergic rhiniti, Life Sciences & Biomedicine, ENDOSCOPIC SINUS SURGERY, Algorithms, Human, Integrated care pathway, Adult, Chronic Disease, Humans, Precision Medicine, Rhinitis, Allergic, Young Adult, Immunology, medicine.medical_specialty, rhinosinusiti, PHENOTYPES, VALIDATION, 03 medical and health sciences, Therapeutic approach, Allergic, Patient satisfaction, Quality of life (healthcare), Patient participation, IMMUNOTHERAPY, Intensive care medicine, Asthma, Science & Technology, business.industry, medicine.disease, Sinusiti, SEVERITY, 030228 respiratory system, 3121 General medicine, internal medicine and other clinical medicine, Physical therapy, ASTHMA, business
Abstract

Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging data on the impact of patient stratification on treatment outcomes, European and American regulatory bodies support the principles of PM and its potential advantage over current treatment strategies. The aim of the current document was to propose a consensus on the position and gradual implementation of the principles of PM within existing adult treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS). At the time of diagnosis, prediction of success of the initiated treatment and patient participation in the decision of the treatment plan can be implemented. The second-level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, and patient participation in the long-term therapeutic strategy. Endotype-driven treatment is part of a personalized approach and should be positioned at the tertiary level of care, given the efforts needed for its implementation and the high cost of molecular diagnosis and biological treatment. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. 72 9 1297 1305

Published
2017

73. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)(Clin Transl Allergy (2016) 6 (29) DOI: 10.1186/s13601-016-0116-9)

Author

Bousquet, Jean, Farrell, J., Crooks, George, Hellings, P. W., Bel, E. H., Bewick, M., Chavannes, Niels H., Sousa, J. Correia de, Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, Anna, Aberer, W., Adachi, M., Agusti, A., Akdis, C. A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A. K., Barbara, Cristina, Bateman, E. D., Beghé, B., Kheder, A. B., Bennoor, K. S., Benson, M., Bergmann, K. C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. W., Camuzat, Thierry, Carlsen, K. H., Carr, W., Carriazo, A. M., Casale, T. B., A.M, Cepeda Sarabia, Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cirule, I., Cox, L., Costa, David J., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Blay, F. De, Dedeu, Antoni, Deleanu, D., Keenoy, E. De Manuel, Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Douagui, H. B., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fabbri, Leonardo M., Fletcher, M., Fiocchi, A., Fink-Wagner, A., Fonseca, J. A., Fokkens, W. J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, Judith, Gemicioǧlu, B., Gereda, J. E., Diaz, S. González, Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Heaney, L. G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J. O. B., Howarth, P. H., Humbert, M., Hyland, M. E., Illario, M., Ivancevich, J. C., Jardim, J. R., Jares, E. J., Jeandel, Claude, Jenkins, C., Johnston, S. L., Jonquet, Olivier, Julge, K., Jung, K. S., Just, J., Kaidashev, I. P., Khaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, Tuyen D., Lieberman, P., Lipworth, B. J., Li, J., Carlsen, K. C. Lodrup, Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M. J., Manning, P. J., Mara, S., Marshall, G. D., Masjedi, M. R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Menzies-Gow, A., Merk, H., Michel, J. P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G. M. Y., Molimard, M., Momas, I., Montilla-Santana, A., Almeida, M. Morais, Morgan, M., Mosges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R. N., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H. S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Postma, D. S., Price, D., Rabe, K. F., Raciborski, F., Radier-Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez-Mañas, L., Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G. K., Schunemann, H. J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, K. M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Sunyer, Jordi, Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Valia, E., Valovirta, E., Ganse, E. Van, Hage, M. van, Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D. Y., Wahn, U., Wickman, M., Williams, D. M., Williams, S., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, Jacques, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Bousquet, J., Farrell, J., Crooks, G., Hellings, P., Bel, E. H., Bewick, M., Chavannes, N. H., De Sousa, J. C., Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, A., Aberer, W., Adachi, M., Agusti, A., Akdis, C. A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Kheder, A. B., Bennoor, K. S., Benson, M., Bergmann, K. C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. W., Camuzat, T., Carlsen, K. H., Carr, W., Carriazo, A., Casale, T., Cepeda Sarabia, A. M., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciprandi, G., Cirule, I., Cox, L., Costa, D. J., Custovic, A., Dahl, R., Dahlen, S. E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., De Manuel Keenoy, E., Demoly, P., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fabbri, L. M., Fletcher, M., Fiocchi, A., Fink Wagner, A., Fonseca, J., Fokkens, W. J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, J., Gemicioglu, B., Gereda, J. E., Gonzalez Diaz, S., Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzman, M. A., Heaney, L. G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J. O. B., Howarth, P., Humbert, M., Hyland, M. E., Illario, M., Ivancevich, J. C., Jardim, J. R., Jares, E. J., Jeandel, C., Jenkins, C., Johnston, S. L., Jonquet, O., Julge, K., Jung, K. S., Just, J., Kaidashev, I. P., Khaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Klimek, L., Koffi N'Goran, B., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Lodrup Carlsen, K., Louis, R., Macnee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M. J., Manning, P., Mara, S., Marshall, G. D., Masjedi, M. R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Menzies-Gow, A., Merk, H., Michel, J. P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G. M. Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Morgan, M., Mosges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Scholl, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H. S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Postma, D., Price, D., Rabe, K. F., Raciborski, F., Radier Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez Manas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G. K., Schunemann, H. J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Sunyer, J., Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Valia, E., Valovirta, E., Van Ganse, E., Van Hage, M., Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, G., Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D. Y., Wahn, U., Wickman, M., Williams, D. M., Williams, S., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., and Mercier, J.

Subjects
Pulmonary and Respiratory Medicine, Immunology, Immunology and Allergy
Abstract

7 1

Published
2017

74. Low maternal vitamin D status in pregnancy increases the risk of childhood obesity

Author

Daraki, V., Roumeliotaki, T., Chalkiadaki, G., Katrinaki, M., Karachaliou, M., Leventakou, V., Vafeiadi, M., Sarri, K., Vassilaki, M., Papavasiliou, S., Kogevinas, M., Chatzi, L., RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, and RS: NUTRIM - R4 - Gene-environment interaction

Subjects
child lipids, BODY-COMPOSITION, vitamin D, CHILDREN, D DEFICIENCY, child obesity, ADIPOSE-TISSUE, AGE, ADOLESCENCE, INFANCY, Child blood pressure, GROWTH, COHORT, pregnancy, preschool age
Abstract

Background: Vitamin D may modulate adipogenesis. However, limited studies have investigated the effect of maternal vitamin D during pregnancy on offspring adiposity or cardiometabolic parameters with inconclusive results. Objectives: The objective of this study is to examine the association of maternal 25(OH)-vitamin D [25(OH)D] status with offspring obesity and cardiometabolic characteristics in 532 mother-child pairs from the prospective pregnancy cohort Rhea in Crete, Greece. Methods: Maternal 25(OH)D concentrations were measured at the first prenatal visit (mean: 14 weeks, SD: 4). Child outcomes included body mass index standard deviation score, waist circumference, skin-fold thickness, blood pressure and serum lipids at ages 4 and 6 years. Body fat percentage was also measured at 6 years. Body mass index growth trajectories from birth to 6 years were estimated by mixed effects models with fractional polynomials of age. Adjusted associations were obtained via multivariable linear regression analyses. Results: About two-thirds of participating mothers had 25(OH)D concentrations = 37.7 nmol L-1), on covariate-adjusted analyses. The observed relationships persisted at age 6 years. We found no association between maternal 25(OH)D concentrations and offspring blood pressure or serum lipids at both time points. Conclusions: Exposure to very low 25(OH)D concentrations in utero may increase childhood adiposity indices. Given that vitamin D is a modifiable risk factor, our findings may have important public health implications.

Published
2018

75. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author

Santos, S. Eekhout, I. Voerman, E. Gaillard, R. Barros, H. Charles, M.-A. Chatzi, L. Chevrier, C. Chrousos, G.P. Corpeleijn, E. Costet, N. Crozier, S. Doyon, M. Eggesbø, M. Fantini, M.P. Farchi, S. Forastiere, F. Gagliardi, L. Georgiu, V. Godfrey, K.M. Gori, D. Grote, V. Hanke, W. Hertz-Picciotto, I. Heude, B. Hivert, M.-F. Hryhorczuk, D. Huang, R.-C. Inskip, H. Jusko, T.A. Karvonen, A.M. Koletzko, B. Küpers, L.K. Lagström, H. Lawlor, D.A. Lehmann, I. Lopez-Espinosa, M.-J. Magnus, P. Majewska, R. Mäkelä, J. Manios, Y. McDonald, S.W. Mommers, M. Morgen, C.S. Moschonis, G. Murínová, L. Newnham, J. Nohr, E.A. Andersen, A.-M.N. Oken, E. Oostvogels, A.J.J.M. Pac, A. Papadopoulou, E. Pekkanen, J. Pizzi, C. Polanska, K. Porta, D. Richiardi, L. Rifas-Shiman, S.L. Roeleveld, N. Santa-Marina, L. Santos, A.C. Smit, H.A. Sørensen, T.I.A. Standl, M. Stanislawski, M. Stoltenberg, C. Thiering, E. Thijs, C. Torrent, M. Tough, S.C. Trnovec, T. Van Gelder, M.M.H.J. Van Rossem, L. Von Berg, A. Vrijheid, M. Vrijkotte, T.G.M. Zvinchuk, O. Van Buuren, S. Jaddoe, V.W.V.

Abstract

Background: Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies. Methods: We used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape. Results: We observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4-17.4) for underweight women, 14.5 kg (11.5-17.7) for normal weight women, 13.9 kg (10.1-17.9) for overweight women, and 11.2 kg (7.0-15.7), 8.7 kg (4.3-13.4) and 6.3 kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy complications. Conclusions: Gestational weight gain patterns are strongly related to pre-pregnancy body mass index. The derived charts can be used to assess gestational weight gain in etiological research and as a monitoring tool for weight gain during pregnancy in clinical practice. © 2018 The Author(s).

Published
2018

76. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author

Felix, JF, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baïz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Munthe-Kaas, M, Corpeleijn, E, Czamara, D, Dabelea, D, Smith, G, De Boever, P, Duijts, L, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Håberg, SE, Herceg, Z, Hivert, M-F, Holland, N, Holloway, JW, Hoyo, C, Hu, D, Huang, R-C, Huen, K, Järvelin, M-R, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Küpers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melén, E, Melton, P, Murphy, SK, Nawrot, TS, Nisticò, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sørensen, TIA, Starling, AP, Sunyer, J, Taylor, JA, Tiemeier, H, Ullemar, V, Vafeiadi, M, Van Ijzendoorn, MH, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, C-J, Xu, Z, Yang, IV, Yousefi, P, Zhang, H, Zhang, W, Zhao, S, Agha, G, Relton, CL, Jaddoe, VWV, London, SJ, Epidemiology, Erasmus MC other, Pediatrics, Child and Adolescent Psychiatry / Psychology, Psychiatry, Research Methods and Techniques, dIRAS RA-2, One Health Chemisch, Reproductive Origins of Adult Health and Disease (ROAHD), Lifestyle Medicine (LM), Groningen Research Institute for Asthma and COPD (GRIAC), Life Course Epidemiology (LCE), Department of Psychology and Logopedics, Helsinki Collegium for Advanced Studies, Medicum, University of Helsinki, and Developmental Psychology Research Group

Subjects
DNA Methylation/physiology, Epidemiology, Maternal Health, education, Embaràs, DISEASE, Environmental Pollution/analysis, Epigenesis, Genetic, Cohort Studies, Prenatal Exposure Delayed Effects/epidemiology, Folic Acid, Pregnancy, Journal Article, Humans, MATERNAL SMOKING, CORD BLOOD, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Cohort Profiles, METAANALYSIS, PRENATAL EXPOSURE, Maternal Exposure/adverse effects, EPIGENOME-WIDE ASSOCIATION, 0104 Statistics, Child Health, Infant, Newborn, DNA METHYLATION DATA, DNA Methylation, Epigenètica, BIRTH-WEIGHT, 3142 Public health care science, environmental and occupational health, Folic Acid/blood, 1117 Public Health And Health Services, Maternal Exposure, Prenatal Exposure Delayed Effects, MENDELIAN RANDOMIZATION, Epigenetics, Female, Human medicine, Environmental Pollution
Abstract

UK Medical Research Council; Wellcome Trust [102215/2/13/2, WT088806, 084762MA]; UK Biotechnology and Biological Sciences Research Council [BB/I025751/1, BB/I025263/1]; UK Medical Research Council Integrative Epidemiology Unit; University of Bristol [MC_UU_12013_1, MC_UU_12013_2, MC_UU_12013_5, MC_UU_12013_8]; United States National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK10324]; Swedish Research Council; Swedish Heart-Lung Foundation; Freemason Child House Foundation in Stockholm; MeDALL (Mechanisms of the Development of ALLergy), within the European Union [261357]; Stockholm County Council (ALF); Swedish Foundation for Strategic Research (SSF) [RBc08-0027]; Strategic Research Programme (SFO) in Epidemiology at Karolinska Institutet; Swedish Research Council Formas; Swedish Environment Protection Agency; Center for Integrative Research on Childhood Leukemia and the Environment [P01ES018172]; NIH [P50ES018172, R01ES09137, 5P30CA082103, P01 ES009605, R01 ES021369, R01ES023067, K01ES017801, R01ES022216, P30ES007048, R01ES014447, P01ES009581, R826708-01, RD831861-01, P50ES026086, R01DK068001, R01 DK100340, R01 DK076648, R01ES022934, R01HL111108, R01NR013945, R37 HD034568, UL1 TR001082, P30 DK56350]; EPA [RD83451101, RD83615901, RD 82670901, RD 83451301, 83615801-0]; UCSF Comprehensive Cancer Center Support grant [P30 CA82103]; Swiss Science National Foundation [P2LAP3_158674]; Sutter-Stottner Foundation; Commission of the European Community, specific RTD Programme 'Quality of Life and Management of Living Resources' within the 5th Framework Programme [QLRT-2001-00389, QLK1-CT-2002-30582]; 6th Framework Programme [007036]; European Union's Seventh Framework Programme (FP7), project EarlyNutrition [289346]; European Research Council Advanced grant ERC-AdG [322605 META-GROWTH]; Autism Speaks grant [260377]; Funds for Research in Respiratory Health; French Ministry of Research: IFR program; INSERM Nutrition Research Program; French Ministry of Health: Perinatality Program; French National Institute for Population Health Surveillance (INVS); Paris-Sud University; French National Institute for Health Education (INPES); Nestle; Mutuelle Generale de l'Education Nationale (MGEN); French-speaking association for the study of diabetes and metabolism (Alfediam) [2012/51290-6]; EU; European Research Council [ERC-2012-StG.310898, 268479-BREATHE]; Flemish Scientific Research Council (FWO) [N1516112 / G.0.873.11N.10]; European Community's Seventh Framework Programme FP7 project EXPOsOMICS [308610]; People Program (Marie Curie Actions) of the European Union's Seventh Framework Program FP7 under REA grant [628858]; Bijzonder Onderzoeksfonds (BOF) Hasselt University; Ministry of the Flemish Community (Department of Economics, Science and Innovation); Ministry of the Flemish Community (Department of Environment, Nature and Energy); CEFIC LRI award by the Research Foundation-Flanders (FWO); CEFIC LRI award by the Research Foundation-Flanders (FWO) [12L5216N]; Flemish Institute for Technological Research (VITO) [12L5216N]; Bill AMP; Melinda Gates Foundation Grand Challenges Exploration grant [OPP119403]; Sandler Family Foundation; American Asthma Foundation; National Institutes of Health; National Heart, Lung and Blood Institute [HL117004]; National Institute of Environmental Health Sciences [ES24844]; National Institute on Minority Health and Health Disparities [MD006902, MD009523]; National Institute of General Medical Sciences [GM007546]; Tobacco-Related Disease Research Program [24RT-0025]; Hutchison Whampoa Ltd, Hong Kong; University of Groningen; Well Baby Clinic Foundation Icare; Noordlease; Youth Health Care Drenthe; Biobanking and Biomolecular Research Infrastructure Netherlands [CP2011-19]; Erasmus Medical Center, Rotterdam; Erasmus University Rotterdam; Netherlands Organization for Health Research and Development; Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO); Netherlands Consortium for Healthy Aging (NCHA) [050-060-810]; Genetic Laboratory of the Department of Internal Medicine, Erasmus MC; European Union's Horizon research and innovation programme [733206, 633595]; National Institute of Child and Human Development [R01HD068437]; Netherlands Organization for Health Research and Development [VIDI 016.136.361]; Consolidator grant from the European Research Council [ERC-2014-CoG-648916]; Netherlands' Organization for Scientific Research (NWO VICI); European Research Council ERC; Netherlands' Organization for Scientific Research (NWO Spinoza Award); Gravitation program of the Dutch Ministry of Education, Culture, and Science; Netherlands Organization for Scientific Research (NWO) [024.001.003]; Lung Foundation Netherlands [3.2.12.089]; Fonds de Recherche du Quebec en Sante (FRQ-S) [20697]; Canadian Institute of Health Reseach (CIHR) [MOP 115071]; Diabete Quebec grant; Canadian Diabetes Association operating grant [OG-3-08-2622]; American Diabetes Association Pathways Accelerator Early Investigator Award [1-15-ACE-26]; MRC Integrative Epidemiology Unit - Medical Research Council [MC_UU_12013/1-9]; National Institute of Environmental Health Sciences, National Institutes of Health [K99ES025817]; Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041]; Spanish Ministry of Health [FIS-PI04/1436, FIS-PI08/1151]; Spanish Ministry of Health (FEDER funds) [FIS-PI11/00610, FIS-FEDER-PI06/0867, FIS-FEDER-PI03-1615]; Generalitat de Catalunya [CIRIT 1999SGR 00241]; Fundacio La Marato de TV3 [090430]; EU Commission [261357-MeDALL]; National Institute of Allergy and Infectious Diseases [N01-AI90052]; National Institutes of Health USA [R01 HL082925, R01 HL132321]; Asthma UK [364]; NIAID/NIH [R01AI091905, R01AI121226]; National Institute of Health [R01AI121226, R01 AI091905, R01HL132321]; NIH/NIEHS [N01-ES75558]; NIH/NINDS [1 UO1 NS 047537-01, 2 UO1 NS 047537-06A1]; Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01-ES-49019, Z01 ES044005, ES049033, ES049032]; Norwegian Research Council/BIOBANK [221097]; Oslo University Hospital; Unger-Vetlesens foundation; Norwegian American Womens Club; INCA/Plan Cancer-EVA-INSERM, France; International Childhood Cancer Cohort Consortium (I4C); INCA/Plan Cancer-EVA-INSERM (France); IARC Postdoctoral Fellowship; EC FP7 Marie Curie Actions-People-Co-funding of regional, national and international programmes (COFUND); NIEHS [R21ES014947, R01ES016772]; NIDDK [R01DK085173]; National Institute of Environmental Health Science [P30 ES025128]; University of Oulu grant [65354]; Oulu University Hospital [2/97, 8/97]; Ministry of Health and Social Affairs [23/251/97, 160/97, 190/97]; National Institute for Health and Welfare, Helsinki [54121]; Regional Institute of Occupational Health, Oulu, Finland [50621, 54231]; EU [QLG1-CT-2000-01643, E51560]; NorFA grant [731, 20056, 30167]; Academy of Finland; NIH-NIEHS [P01 ES022832]; US EPA [RD83544201]; NIH-NIGMS [P20GM104416]; NCI [R25CA134286]; Netherlands Organization for Scientific Research and Development; Netherlands Asthma Fund; Netherlands Ministry of Spatial Planning, Housing, and the Environment; Netherlands Ministry of Health, Welfare, and Sport; MeDALL; European Union under the Health Cooperation Work Program of the 7th Framework program [261357]; Italian National Centre for Disease Prevention and Control (CCM grant); Italian Ministry of Health (art 12); Italian Ministry of Health (12bis Dl.gs.vo) [502/92]; EraNet; EVO; University of Helsinki Research Funds; Signe and Ane Gyllenberg foundation; Emil Aaltonen Foundation; Finnish Medical Foundation; Jane and Aatos Erkko Foundation; Novo Nordisk Foundation; Paivikki and Sakari Sohlberg Foundation; Sigrid Juselius Foundation; University of Helsinki; University of Western Australia (UWA); Curtin University; Raine Medical Research Foundation; UWA Faculty of Medicine, Dentistry and Health Sciences; Telethon Kids Institute; Women's and Infant's Research Foundation (KEMH); Edith Cowan University; National Health and Medical Research Council [1059711]; National Health and Medical Research Council (NHMRC) fellowship [1053384]; Australian National Health and Medical Research Council; United States National Institute of Health; Greek Ministry of Health (programme of prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece); Greek Ministry of Health ('Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health); European Union (EU) [EU FP6-2003-Food-3-NewGeneris, EU FP7 ENV.2007.1.2.2.2, 211250 ESCAPE, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7 ENV.2008.1.2.1.6, 226285 ENRIECO]; National Institutes of Health [NIH-NIMH R01MH094609, NIH-NIEHS R01ES022223, NIH-NIEHS R01ES025145]; Centers for Disease Control and Prevention [U10DD000180, U10DD000181, U10DD000182, U10DD000183, U10DD000184, U10DD000498]; Autism Speaks [7659]; Swedish Research Council through the Swedish Initiative for research on Microdata in the Social And Medical Sciences (SIMSAM) [340-2013-5867]; Stockholm County Council (ALF projects); Strategic Research Program in Epidemiology at Karolinska Institutet; Swedish Asthma and Allergy Association's Research Foundation; Stiftelsen Frimurare Barnahuset Stockholm; Norwegian Ministry of Health and Care Services; Ministry of the Flemish Community (Flemish Agency for Care and Health); University of Bristol; Ministry of Education and Research; European Union (EU) (EU FP7-HEALTH-single stage CHICOS); European Union (EU) (EU-FP7-HEALTH) [308333 HELIX]; European Union (EU) (EU FP6. STREP HiWATE); UK Medical Research Council; Wellcome Trust [102215/2/13/2, WT088806, 084762MA]; UK Biotechnology and Biological Sciences Research Council [BB/I025751/1, BB/I025263/1]; UK Medical Research Council Integrative Epidemiology Unit; University of Bristol [MC_UU_12013_1, MC_UU_12013_2, MC_UU_12013_5, MC_UU_12013_8]; United States National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK10324]; Swedish Research Council; Swedish Heart-Lung Foundation; Freemason Child House Foundation in Stockholm; MeDALL (Mechanisms of the Development of ALLergy), within the European Union [261357]; Stockholm County Council (ALF); Swedish Foundation for Strategic Research (SSF) [RBc08-0027]; Strategic Research Programme (SFO) in Epidemiology at Karolinska Institutet; Swedish Research Council Formas; Swedish Environment Protection Agency; Center for Integrative Research on Childhood Leukemia and the Environment [P01ES018172]; NIH [P50ES018172, R01ES09137, 5P30CA082103, P01 ES009605, R01 ES021369, R01ES023067, K01ES017801, R01ES022216, P30ES007048, R01ES014447, P01ES009581, R826708-01, RD831861-01, P50ES026086, R01DK068001, R01 DK100340, R01 DK076648, R01ES022934, R01HL111108, R01NR013945, R37 HD034568, UL1 TR001082, P30 DK56350]; EPA [RD83451101, RD83615901, RD 82670901, RD 83451301, 83615801-0]; UCSF Comprehensive Cancer Center Support grant [P30 CA82103]; Swiss Science National Foundation [P2LAP3_158674]; Sutter-Stottner Foundation; Commission of the European Community, specific RTD Programme 'Quality of Life and Management of Living Resources' within the 5th Framework Programme [QLRT-2001-00389, QLK1-CT-2002-30582]; 6th Framework Programme [007036]; European Union's Seventh Framework Programme (FP7), project EarlyNutrition [289346]; European Research Council Advanced grant ERC-AdG [322605 META-GROWTH]; Autism Speaks grant [260377]; Funds for Research in Respiratory Health; French Ministry of Research: IFR program; INSERM Nutrition Research Program; French Ministry of Health: Perinatality Program; French National Institute for Population Health Surveillance (INVS); Paris-Sud University; French National Institute for Health Education (INPES); Nestle; Mutuelle Generale de l'Education Nationale (MGEN); French-speaking association for the study of diabetes and metabolism (Alfediam) [2012/51290-6]; EU; European Research Council [ERC-2012-StG.310898, 268479-BREATHE]; Flemish Scientific Research Council (FWO) [N1516112 / G.0.873.11N.10]; European Community's Seventh Framework Programme FP7 project EXPOsOMICS [308610]; People Program (Marie Curie Actions) of the European Union's Seventh Framework Program FP7 under REA grant [628858]; Bijzonder Onderzoeksfonds (BOF) Hasselt University; Ministry of the Flemish Community (Department of Economics, Science and Innovation); Ministry of the Flemish Community (Department of Environment, Nature and Energy); CEFIC LRI award by the Research Foundation-Flanders (FWO); CEFIC LRI award by the Research Foundation-Flanders (FWO) [12L5216N]; Flemish Institute for Technological Research (VITO) [12L5216N]; Bill AMP; Melinda Gates Foundation Grand Challenges Exploration grant [OPP119403]; Sandler Family Foundation; American Asthma Foundation; National Institutes of Health; National Heart, Lung and Blood Institute [HL117004]; National Institute of Environmental Health Sciences [ES24844]; National Institute on Minority Health and Health Disparities [MD006902, MD009523]; National Institute of General Medical Sciences [GM007546]; Tobacco-Related Disease Research Program [24RT-0025]; Hutchison Whampoa Ltd, Hong Kong; University of Groningen; Well Baby Clinic Foundation Icare; Noordlease; Youth Health Care Drenthe; Biobanking and Biomolecular Research Infrastructure Netherlands [CP2011-19]; Erasmus Medical Center, Rotterdam; Erasmus University Rotterdam; Netherlands Organization for Health Research and Development; Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO); Netherlands Consortium for Healthy Aging (NCHA) [050-060-810]; Genetic Laboratory of the Department of Internal Medicine, Erasmus MC; European Union's Horizon research and innovation programme [733206, 633595]; National Institute of Child and Human Development [R01HD068437]; Netherlands Organization for Health Research and Development [VIDI 016.136.361]; Consolidator grant from the European Research Council [ERC-2014-CoG-648916]; Netherlands' Organization for Scientific Research (NWO VICI); European Research Council ERC; Netherlands' Organization for Scientific Research (NWO Spinoza Award); Gravitation program of the Dutch Ministry of Education, Culture, and Science; Netherlands Organization for Scientific Research (NWO) [024.001.003]; Lung Foundation Netherlands [3.2.12.089]; Fonds de Recherche du Quebec en Sante (FRQ-S) [20697]; Canadian Institute of Health Reseach (CIHR) [MOP 115071]; Diabete Quebec grant; Canadian Diabetes Association operating grant [OG-3-08-2622]; American Diabetes Association Pathways Accelerator Early Investigator Award [1-15-ACE-26]; MRC Integrative Epidemiology Unit - Medical Research Council [MC_UU_12013/1-9]; National Institute of Environmental Health Sciences, National Institutes of Health [K99ES025817]; Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041]; Spanish Ministry of Health [FIS-PI04/1436, FIS-PI08/1151]; Spanish Ministry of Health (FEDER funds) [FIS-PI11/00610, FIS-FEDER-PI06/0867, FIS-FEDER-PI03-1615]; Generalitat de Catalunya [CIRIT 1999SGR 00241]; Fundacio La Marato de TV3 [090430]; EU Commission [261357-MeDALL]; National Institute of Allergy and Infectious Diseases [N01-AI90052]; National Institutes of Health USA [R01 HL082925, R01 HL132321]; Asthma UK [364]; NIAID/NIH [R01AI091905, R01AI121226]; National Institute of Health [R01AI121226, R01 AI091905, R01HL132321]; NIH/NIEHS [N01-ES75558]; NIH/NINDS [1 UO1 NS 047537-01, 2 UO1 NS 047537-06A1]; Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01-ES-49019, Z01 ES044005, ES049033, ES049032]; Norwegian Research Council/BIOBANK [221097]; Oslo University Hospital; Unger-Vetlesens foundation; Norwegian American Womens Club; INCA/Plan Cancer-EVA-INSERM, France; International Childhood Cancer Cohort Consortium (I4C); INCA/Plan Cancer-EVA-INSERM (France); IARC Postdoctoral Fellowship; EC FP7 Marie Curie Actions-People-Co-funding of regional, national and international programmes (COFUND); NIEHS [R21ES014947, R01ES016772]; NIDDK [R01DK085173]; National Institute of Environmental Health Science [P30 ES025128]; University of Oulu grant [65354]; Oulu University Hospital [2/97, 8/97]; Ministry of Health and Social Affairs [23/251/97, 160/97, 190/97]; National Institute for Health and Welfare, Helsinki [54121]; Regional Institute of Occupational Health, Oulu, Finland [50621, 54231]; EU [QLG1-CT-2000-01643, E51560]; NorFA grant [731, 20056, 30167]; Academy of Finland; NIH-NIEHS [P01 ES022832]; US EPA [RD83544201]; NIH-NIGMS [P20GM104416]; NCI [R25CA134286]; Netherlands Organization for Scientific Research and Development; Netherlands Asthma Fund; Netherlands Ministry of Spatial Planning, Housing, and the Environment; Netherlands Ministry of Health, Welfare, and Sport; MeDALL; European Union under the Health Cooperation Work Program of the 7th Framework program [261357]; Italian National Centre for Disease Prevention and Control (CCM grant); Italian Ministry of Health (art 12); Italian Ministry of Health (12bis Dl.gs.vo) [502/92]; EraNet; EVO; University of Helsinki Research Funds; Signe and Ane Gyllenberg foundation; Emil Aaltonen Foundation; Finnish Medical Foundation; Jane and Aatos Erkko Foundation; Novo Nordisk Foundation; Paivikki and Sakari Sohlberg Foundation; Sigrid Juselius Foundation; University of Helsinki; University of Western Australia (UWA); Curtin University; Raine Medical Research Foundation; UWA Faculty of Medicine, Dentistry and Health Sciences; Telethon Kids Institute; Women's and Infant's Research Foundation (KEMH); Edith Cowan University; National Health and Medical Research Council [1059711]; National Health and Medical Research Council (NHMRC) fellowship [1053384]; Australian National Health and Medical Research Council; United States National Institute of Health; Greek Ministry of Health (programme of prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece); Greek Ministry of Health ('Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health); European Union (EU) [EU FP6-2003-Food-3-NewGeneris, EU FP7 ENV.2007.1.2.2.2, 211250 ESCAPE, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7 ENV.2008.1.2.1.6, 226285 ENRIECO]; National Institutes of Health [NIH-NIMH R01MH094609, NIH-NIEHS R01ES022223, NIH-NIEHS R01ES025145]; Centers for Disease Control and Prevention [U10DD000180, U10DD000181, U10DD000182, U10DD000183, U10DD000184, U10DD000498]; Autism Speaks [7659]; Swedish Research Council through the Swedish Initiative for research on Microdata in the Social And Medical Sciences (SIMSAM) [340-2013-5867]; Stockholm County Council (ALF projects); Strategic Research Program in Epidemiology at Karolinska Institutet; Swedish Asthma and Allergy Association's Research Foundation; Stiftelsen Frimurare Barnahuset Stockholm; Norwegian Ministry of Health and Care Services; Ministry of the Flemish Community (Flemish Agency for Care and Health); University of Bristol; Ministry of Education and Research; European Union (EU) (EU FP7-HEALTH-single stage CHICOS); European Union (EU) (EU-FP7-HEALTH) [308333 HELIX]; European Union (EU) (EU FP6. STREP HiWATE); [R01ES017646]; [R01ES01900]; [R01ES16443]; [USA / NIHH 2000 G DF682]; [50945]; [R01 HL095606]; [R01 HL1143396]

Published
2018
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77. Pregnancy, perinatal and postpartum complications as determinants of postpartum depression: the Rhea mother-child cohort in Crete, Greece

Author

Koutra, K. Vassilaki, M. Georgiou, V. Koutis, A. and Bitsios, P. Kogevinas, M. Chatzi, L.

Abstract

Aims. Few epidemiological studies evaluated associations between perinatal complications and maternal mood at the early postpartum period and the findings are inconsistent. We aimed at investigating a wide range of complications during pregnancy, at delivery, and at the early postpartum period as determinants of postpartum depression (PPD) at 8 weeks postpartum. Methods. A total of 1037 women who enrolled in the Rhea mother-child cohort in Crete, Greece participated in the present study. Information on pregnancy, perinatal and postpartum complications was obtained from clinical records or by questionnaires. Postpartum depressive symptoms were assessed at 8 weeks postpartum using the Edinburgh Postnatal Depression Scale (EPDS). Multivariable linear and logistic regression models were fit to estimate the association between pregnancy, perinatal and postpartum complications and maternal depressive symptoms, adjusting also for potential confounders. Results. The prevalence of women with probable depression (EPDS score >= 13) was 13.6% at 8 weeks postpartum. Gestational hypertension and/or preeclampsia (beta coefficient 1.86, 95% CI: 0.32, 3.41) and breastfeeding difficulties (beta coefficient 0.77, 95% CI: 0.02, 1.53) were significantly associated with higher PPD symptoms. Sleep patterns during pregnancy, such as sleep deprivation (OR = 3.57, 95% CI: 1.91, 6.67) and snoring (OR = 1.81, 95% CI: 1.11, 2.93), and breastfeeding duration less than 2 months (OR = 1.77, 95% CI: 1.19, 2.64) were significantly associated with increase in the odds for PPD. Some other complications, such as unplanned pregnancy and hospitalisation during pregnancy were also associated with EPDS score, but these associations were explained by socio-demographic characteristics of the mother. Conclusions. We found that several pregnancy, perinatal and postpartum complications may have an adverse effect on maternal mood at the early postpartum period. These findings have considerable implications for developing effective prevention and early psychoeducational intervention strategies for women at risk of developing PPD.

Published
2018

78. Association between prenatal exposure to air pollution and inflammatory markers in children

Author

Marina Vafeiadi, Chatzi L, Theano Roumeliotaki, Margetaki K, Georgia Chalkiadaki, Kogevinas M, and Eirini Dermitzaki

Subjects
Global and Planetary Change, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Environmental health, Public Health, Environmental and Occupational Health, Air pollution, Medicine, business, medicine.disease_cause, Pollution, Prenatal exposure
Published
2019
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79. Exposure to traffic-related air pollution and thyroid function during pregnancy

Author

López M, Mònica Guxens, Lertxundi A, Akhgar Ghassabian, Chatzi L, Adonina Tardón, Peeters R, Oken E, Livia Pierotti, and Vrijkotte T

Subjects
Global and Planetary Change, Pregnancy, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Air pollution, medicine.disease_cause, medicine.disease, Pollution, Environmental health, medicine, Thyroid function, business, Cohort study
Published
2019
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81. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Makela, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., Xu, C., dIRAS RA-2, Risk Assessment, Clinicum, Department of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J.M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D.S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B.N., Lodrup Carlsen, K.C., Koppelman, G.H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M.L., Maier, D., Melén, E., Palkonen, S., Smit, H.A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K.H., Chatzi, L., Coquet, J.M., Curin, M., Demoly, P., Eller, E., Fantini, M.P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., Mceachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Rancière, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M.J., Siroux, V., Tischer, C.G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., and Xu, C.

Subjects
multimorbidity, EUROPEAN INNOVATION PARTNERSHIP, humanos, Immunology, IGE SENSITIZATION, política de salud, Review, rhinitis, Inventions, Unión Europea, Hypersensitivity, Medicine and Health Sciences, Journal Article, Humans, Immunology and Allergy, ATOPIC-DERMATITIS, European Union, biología de sistemas, hipersensibilidad, inmunización, inmunoglobulina E, Asthma, Ige, Multimorbidity, Polysensitization, Rhinitis, BIRTH COHORT, IMMUNE-RESPONSES, Health Policy, Systems Biology, asthma, IgE, polysensitization, CHILDHOOD ASTHMA, invenciones, Immunoglobulin E, Prognosis, INTEGRATED CARE, pronóstico, rhiniti, CHRONIC RESPIRATORY-DISEASES, 3121 General medicine, internal medicine and other clinical medicine, Immunization, IMMUNOLOGICAL REACTIVITY, IMMUNOGLOBULIN-E
Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016
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82. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author

Bousquet, Jean, Farrell, J., Crooks, George, Hellings, P. W., Bel, E. H., Bewick, M., Chavannes, Niels H., Sousa, J. Correia de, Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, Anna, Aberer, W., Adachi, M., Agusti, A., Akdis, C. A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A. K., Barbara, Cristina, Bateman, E. D., Beghé, B., Kheder, A. B., Bennoor, K. S., Benson, M., Bergmann, K. C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. W., Camuzat, Thierry, Carlsen, K. H., Carr, W., Carriazo, A. M., Casale, T. B., A.M, Cepeda Sarabia, Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cirule, I., Cox, L., Costa, David J., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Blay, F. De, Dedeu, Antoni, Deleanu, D., Keenoy, E. De Manuel, Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Douagui, H. B., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fabbri, Leonardo M., Fletcher, M., Fiocchi, A., Fink-Wagner, A., Fonseca, J. A., Fokkens, W. J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, Judith, Gemicioǧlu, B., Gereda, J. E., Diaz, S. González, Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Heaney, L. G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J. O. B., Howarth, P. H., Humbert, M., Hyland, M. E., Illario, M., Ivancevich, J. C., Jardim, J. R., Jares, E. J., Jeandel, Claude, Jenkins, C., Johnston, S. L., Jonquet, Olivier, Julge, K., Jung, K. S., Just, J., Kaidashev, I. P., Kaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, Tuyen D., Lieberman, P., Lipworth, B. J., Li, J., Carlsen, K. C. Lodrup, Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M. J., Manning, P. J., Mara, S., Marshall, G. D., Masjedi, M. R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Menzies-Gow, A., Merk, H., Michel, J. P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G. M. Y., Molimard, M., Momas, I., Montilla-Santana, A., Almeida, M. Morais, Morgan, M., Mosges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R. N., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H. S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Postma, D. S., Price, D., Rabe, K. F., Raciborski, F., Radier-Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez-Mañas, L., Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G. K., Schunemann, H. J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, K. M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Sunyer, Jordi, Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Valia, E., Valovirta, E., Ganse, E. Van, Hage, M. van, Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D. Y., Wahn, U., Wickman, M., Williams, D. M., Williams, S., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, Jacques, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E. H, Bewick, M, Chavannes, N. H, de Sousa, J. Correia, Cruz, A. A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C. A, Akdis, M, Ankri, J, Alonso, A, Annesi Maesano, I, Ansotegui, I. J, Anto, J. M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A. K, Barbara, C, Bateman, E. D, Beghé, B, Kheder, A. Ben, Bennoor, K. S, Benson, M, Bergmann, K. C, Bieber, T, Bindslev Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A. L, Bonini, M, Bonini, Sergio, Bosnic Anticevitch, S, Boulet, L. P, Bourret, R, Bousquet, P. J, Braido, F, Briggs, A. H, Brightling, C. E, Brozek, J, Buhl, R, Burney, P. G, Bush, A, Caballero Fonseca, F, Caimmi, D, Calderon, M. A, Calverley, P. M, Camargos, P. A. M, Canonica, G. W, Camuzat, T, Carlsen, K. H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A. M, Chatzi, L, Chen, Y. Z, Chiron, R, Chkhartishvili, E, Chuchalin, A. G, Chung, K. F, Ciprandi, G, Cirule, I, Cox, L, Costa, D. J, Custovic, A, Dahl, R, Dahlen, S. E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J. A, Devillier, P, Didier, A, Dinh Xuan, A. T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S. R, Dykewicz, M. S, El Gamal, Y, Emuzyte, R, Fabbri, L. M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W. J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia Aymerich, J, Gemicioğlu, B, Gereda, J. E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M. A, Heaney, L. G, Hellquist Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J. O' B, Howarth, P, Humbert, M, Hyland, M. E, Illario, M, Ivancevich, J. C, Jardim, J. R, Jares, E. J, Jeandel, C, Jenkins, C, Johnston, S. L, Jonquet, O, Julge, K, Jung, K. S, Just, J, Kaidashev, I, Kaitov, M. R, Kalayci, O, Kalyoncu, A. F, Keil, T, Keith, P. K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G. H, Kowalski, M. L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas Linnemann, D, Laune, D, Le, L. T. T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, Macnee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M. J, Manning, P, Mara, S, Marshall, G. D, Masjedi, M. R, Matignon, P, Maurer, M, Mavale Manuel, S, Melén, E, Melo Gomes, E, Meltzer, E. O, Menzies Gow, A, Merk, H, Michel, J. P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G. M. Y, Molimard, M, Momas, I, Montilla Santana, A, Morais Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T. D, O'Hehir, R. E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H. S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T. A, Portejoie, F, Potter, P, Postma, D, Price, D, Rabe, K. F, Raciborski, F, Radier Pontal, F, Repka Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez Borges, M, Scadding, G. K, Schunemann, H. J, Serrano, E, Schmid Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F. E. R, Sisul, J. C, Skrindo, I, Smit, H. A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P. J, Sunyer, J, Thijs, C, To, T, Todo Bom, A, Triggiani, M, Valenta, R, Valero, A. L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D. Y, Wahn, U, Wickman, M, Williams, D. M, Williams, S, Wright, J, Yawn, B. P, Yiallouros, P. K, Yusuf, O. M, Zaidi, A, Zar, H. J, Zernotti, M. E, Zhang, L, Zhong, N, Zidarn, M, Mercier, J., Clinicum, Department of Dermatology, Allergology and Venereology, Department of Medicine, Timo Strandberg / Principal Investigator, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Department of Paediatrics and Child Health, Faculty of Health Sciences, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Bonini, S, Illario, Maddalena, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Çocuk Sağlığı ve Hastalıkları, Department of Physics, Faculty of Science, and Universidade do Minho

Subjects
Pulmons -- Malalties obstructives, Veterinary medicine, Allergy, Published Erratum, LANGUEDOC-ROUSSILLON, Respiratory Medicine and Allergy, [SDV]Life Sciences [q-bio], Aparell respiratori -- Malalties, OPERATIONAL DEFINITION, Alternative medicine, Review, Chronic respiratory diseases, GLOBAL ALLIANCE, SYSTEMS MEDICINE, 0302 clinical medicine, Medicine and Health Sciences, Immunology and Allergy, MACVIA, 030212 general & internal medicine, AIRWAYS ICP, Lungmedicin och allergi, EIP on AHA, European Innovation Partnership on Active and Healthy Ageing, AIRWAYS ICPs, ARIA, Scaling up, GINA STRATEGY, AIRWAYS, UPDATE ARIA 2008, Respiratory disease, Outras Ciências Agrárias [Ciências Agrárias], 3. Good health, Chronic respiratory disease, ALLERGIC RHINITIS, ICPs, General partnership, Action plan, Erratum, Life Sciences & Biomedicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Emerging technologies, Immunology, REFERENCE SITE, Socio-culturale, Predictive medicine, 03 medical and health sciences, Nursing, Critical success factor, Journal Article, medicine, ddc:610, Science & Technology, business.industry, Settore MED/09 - MEDICINA INTERNA, AIRWAYS-ICPS, medicine.disease, Integrated care, Alliance, 030228 respiratory system, Ciências Agrárias::Outras Ciências Agrárias, 3121 General medicine, internal medicine and other clinical medicine, Family medicine, Healthy ageing, business, SEVERE ASTHMA
Abstract

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing. Electronic supplementary material The online version of this article (doi:10.1186/s13601-016-0116-9) contains supplementary material, which is available to authorized users.

Published
2016
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83. Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Author

Beaumont, R.N. (Robin N.), Warrington, N.M. (Nicole), Cavadino, A. (Alana), Tyrrell, A.W.R., Nodzenski, M. (Michael), Horikoshi, M. (Momoko), Geller, F. (Frank), Myhre, R. (Ronny), Richmond, R.C. (Rebecca C.), Paternoster, L. (Lavinia), Bradfield, J.P. (Jonathan), Kreiner-Møller, E. (Eskil), Huikari, V. (Ville), Metrustry, S. (Sarah), Lunetta, K.L. (Kathryn), Painter, J.N. (Jodie N.), Hottenga, J.J. (Jouke Jan), Allard, C. (Catherine), Barton, S.J. (Sheila), Espinosa, A. (Ana), Marsh, J.A. (Julie), Potter, C. (Catherine), Zhang, G. (Ge), Ang, W.Q. (Wei), Berry, D. (Diane), Bouchard, L. (Luigi), Das, S. (Shikta), Hakonarson, H. (Hakon), Heikkinen, J. (Jani), Helgeland, Ø. (Øyvind), Hocher, B. (Berthold), Hofman, A. (Albert), Inskip, H.M. (Hazel), Jones, S.E. (Samuel E.), Kogevinas, M. (Manolis), Lind, P.A. (Penelope), Marullo, L. (Letizia), Medland, S.E. (Sarah), Murray, A. (Anna), Murray, J.C. (Jeffrey C.), Njølstad, P.R. (Pa l R.), Nohr, C. (Christian), Reichetzeder, C. (Christoph), Ring, S.M. (Susan), Ruth, K.S. (Katherine S.), Santa-Marina, L. (Loreto), Scholtens, D.M. (Denise M.), Sebert, S. (Sylvain), Sengpiel, V. (Verena), Tuke, M.A. (Marcus A.), Vaudel, M. (Marc), Weedon, M.N. (Michael), Willemsen, G.A.H.M. (Gonneke), Wood, A.R. (Andrew R.), Yaghootkar, H. (Hanieh), Muglia, L.J. (Louis J.), Bartels, M. (Meike), Relton, C.L. (Caroline), Pennell, C.E. (Craig), Chatzi, L. (Leda), Estivill, X. (Xavier), Holloway, J.W. (John W.), Boomsma, D.I. (Dorret), Montgomery, G.W. (Grant W.), Murabito, J. (Joanne), Spector, T.D. (Timothy), Power, C. (Christine), Järvelin, M.-R. (Marjo-Ritta), Bisgaard, H. (Hans), Grant, S.F.A. (Struan F.A.), Sørensen, T.I.A. (Thorkild I.A.), Jaddoe, V.W. (Vincent W.), Jacobsson, B. (Bo), Melbye, M. (Mads), McCarthy, M.I. (Mark I.), Hattersley, A.T. (Andrew), Hayes, M.G. (M. Geoffrey), Frayling, T.M. (Timothy), Hivert, M.-F. (Marie-France), Felix, J.F. (Janine), Hyppönen, E. (Elina), Lowe, W.L. (William L.), Evans, D.M. (David M.), Lawlor, D.A. (Debbie A.), Feenstra, B. (Bjarke), Freathy, R.M. (Rachel), Beaumont, R.N. (Robin N.), Warrington, N.M. (Nicole), Cavadino, A. (Alana), Tyrrell, A.W.R., Nodzenski, M. (Michael), Horikoshi, M. (Momoko), Geller, F. (Frank), Myhre, R. (Ronny), Richmond, R.C. (Rebecca C.), Paternoster, L. (Lavinia), Bradfield, J.P. (Jonathan), Kreiner-Møller, E. (Eskil), Huikari, V. (Ville), Metrustry, S. (Sarah), Lunetta, K.L. (Kathryn), Painter, J.N. (Jodie N.), Hottenga, J.J. (Jouke Jan), Allard, C. (Catherine), Barton, S.J. (Sheila), Espinosa, A. (Ana), Marsh, J.A. (Julie), Potter, C. (Catherine), Zhang, G. (Ge), Ang, W.Q. (Wei), Berry, D. (Diane), Bouchard, L. (Luigi), Das, S. (Shikta), Hakonarson, H. (Hakon), Heikkinen, J. (Jani), Helgeland, Ø. (Øyvind), Hocher, B. (Berthold), Hofman, A. (Albert), Inskip, H.M. (Hazel), Jones, S.E. (Samuel E.), Kogevinas, M. (Manolis), Lind, P.A. (Penelope), Marullo, L. (Letizia), Medland, S.E. (Sarah), Murray, A. (Anna), Murray, J.C. (Jeffrey C.), Njølstad, P.R. (Pa l R.), Nohr, C. (Christian), Reichetzeder, C. (Christoph), Ring, S.M. (Susan), Ruth, K.S. (Katherine S.), Santa-Marina, L. (Loreto), Scholtens, D.M. (Denise M.), Sebert, S. (Sylvain), Sengpiel, V. (Verena), Tuke, M.A. (Marcus A.), Vaudel, M. (Marc), Weedon, M.N. (Michael), Willemsen, G.A.H.M. (Gonneke), Wood, A.R. (Andrew R.), Yaghootkar, H. (Hanieh), Muglia, L.J. (Louis J.), Bartels, M. (Meike), Relton, C.L. (Caroline), Pennell, C.E. (Craig), Chatzi, L. (Leda), Estivill, X. (Xavier), Holloway, J.W. (John W.), Boomsma, D.I. (Dorret), Montgomery, G.W. (Grant W.), Murabito, J. (Joanne), Spector, T.D. (Timothy), Power, C. (Christine), Järvelin, M.-R. (Marjo-Ritta), Bisgaard, H. (Hans), Grant, S.F.A. (Struan F.A.), Sørensen, T.I.A. (Thorkild I.A.), Jaddoe, V.W. (Vincent W.), Jacobsson, B. (Bo), Melbye, M. (Mads), McCarthy, M.I. (Mark I.), Hattersley, A.T. (Andrew), Hayes, M.G. (M. Geoffrey), Frayling, T.M. (Timothy), Hivert, M.-F. (Marie-France), Felix, J.F. (Janine), Hyppönen, E. (Elina), Lowe, W.L. (William L.), Evans, D.M. (David M.), Lawlor, D.A. (Debbie A.), Feenstra, B. (Bjarke), and Freathy, R.M. (Rachel)

Abstract

Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86 577 women of Eu

Published
2018
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84. DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Author

Xu, C.J., Soderhall, C., Bustamante, M., Baiz, N., Gruzieva, O., Gehring, U., Mason, D., Chatzi, L., Basterrechea, M., Llop, S., Torrent, M., Forastiere, F., Fantini, M.P., Carlsen, K.C.L., Haahtela, T., Morin, A., Kerkhof, M. van de, Merid, S.K., Rijkom, B. van, Jankipersadsing, S.A., Bonder, M.J., Ballereau, S., Vermeulen, C.J., Aguirre-Gamboa, R., Jongste, J.C. de, Smit, H.A., Kumar, A., Pershagen, G., Guerra, S., Garcia-Aymerich, J., Greco, D., Reinius, L., McEachan, R.R.C., Azad, R., Hovland, V., Mowinckel, P., Alenius, H., Fyhrquist, N., Lemonnier, N., Pellet, J., Auffray, C., Vlies, P., Diemen, C.C. van, Li, Y., Wijmenga, C., Netea, M.G., Moffatt, M.F., Cookson, W., Anto, J.M., Bousquet, J., Laatikainen, T., Laprise, C., Carlsen, K.H., Gori, D., Porta, D., Iniguez, C., Bilbao, J.R., Kogevinas, M., Wright, J., Brunekreef, B., Kere, J., Nawijn, M.C., Annesi-Maesano, I., Sunyer, J., Melen, E., Koppelman, G.H., Xu, C.J., Soderhall, C., Bustamante, M., Baiz, N., Gruzieva, O., Gehring, U., Mason, D., Chatzi, L., Basterrechea, M., Llop, S., Torrent, M., Forastiere, F., Fantini, M.P., Carlsen, K.C.L., Haahtela, T., Morin, A., Kerkhof, M. van de, Merid, S.K., Rijkom, B. van, Jankipersadsing, S.A., Bonder, M.J., Ballereau, S., Vermeulen, C.J., Aguirre-Gamboa, R., Jongste, J.C. de, Smit, H.A., Kumar, A., Pershagen, G., Guerra, S., Garcia-Aymerich, J., Greco, D., Reinius, L., McEachan, R.R.C., Azad, R., Hovland, V., Mowinckel, P., Alenius, H., Fyhrquist, N., Lemonnier, N., Pellet, J., Auffray, C., Vlies, P., Diemen, C.C. van, Li, Y., Wijmenga, C., Netea, M.G., Moffatt, M.F., Cookson, W., Anto, J.M., Bousquet, J., Laatikainen, T., Laprise, C., Carlsen, K.H., Gori, D., Porta, D., Iniguez, C., Bilbao, J.R., Kogevinas, M., Wright, J., Brunekreef, B., Kere, J., Nawijn, M.C., Annesi-Maesano, I., Sunyer, J., Melen, E., and Koppelman, G.H.

Abstract

Contains fulltext : 193339.pdf (publisher's version ) (Closed access), BACKGROUND: DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with childhood asthma. METHODS: We did a large-scale epigenome-wide association study (EWAS) within the Mechanisms of the Development of ALLergy (MeDALL) project. We examined epigenome-wide methylation using Illumina Infinium Human Methylation450 BeadChips (450K) in whole blood in 207 children with asthma and 610 controls at age 4-5 years, and 185 children with asthma and 546 controls at age 8 years using a cross-sectional case-control design. After identification of differentially methylated CpG sites in the discovery analysis, we did a validation study in children (4-16 years; 247 cases and 2949 controls) from six additional European cohorts and meta-analysed the results. We next investigated whether replicated CpG sites in cord blood predict later asthma in 1316 children. We subsequently investigated cell-type-specific methylation of the identified CpG sites in eosinophils and respiratory epithelial cells and their related gene-expression signatures. We studied cell-type specificity of the asthma association of the replicated CpG sites in 455 respiratory epithelial cell samples, collected by nasal brushing of 16-year-old children as well as in DNA isolated from blood eosinophils (16 with asthma, eight controls [age 2-56 years]) and compared this with whole-blood DNA samples of 74 individuals with asthma and 93 controls (age 1-79 years). Whole-blood transcriptional profiles associated with replicated CpG sites were annotated using RNA-seq data of subsets of peripheral blood mononuclear cells sorted by fluorescence-activated cell sorting. FINDINGS: 27 methylated CpG sites were identified in the discovery analysis. 14 of these CpG sites were replicated and passed genome-wide significance (p<1.14 x 10(-7)) after meta-analysis. Consistently lower methylation le

Published
2018

85. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author

Santos, S. (Susana), Eekhout, I. (Iris), Voerman, E. (Ellis), Gaillard, R. (Romy), Barros, A.I. (Ana), Charles, M.A., Chatzi, L. (Leda), Chevrier, C. (Cécile), Chrousos, G.P. (George P.), Corpeleijn, W.E. (Willemijn), Costet, N. (Nathalie), Crozier, S. (Sarah), Doyon, M. (Myriam), Eggesbø, M. (Merete), Fantini, M.P. (Maria), Farchi, S. (Sara), Forastiere, F. (Francesco), Gagliardi, L. (Luigi), Georgiu, V. (Vagelis), Godfrey, K.M. (Keith M.), Gori, D. (Davide), Grote, V. (Veit), Hanke, W. (Wojciech), Hertz-Picciotto, I. (Irva), Heude, B. (Barbara), Hivert, M.-F. (Marie-France), Hryhorczuk, D.O. (Daniel), Huang, R.-C. (Rae-Chi), Inskip, H.M. (Hazel), Jusko, T.A. (Todd A), Karvonen, A.M. (Anne M.), Koletzko, B. (Berthold), Küpers, A.M. (Marlijn), Lagström, H. (Hanna), Lawlor, D.A. (Debbie A.), Lehmann, I. (Irina), Lopez-Espinosa, M.-J. (Maria-Jose), Magnus, P. (Per), Majewska, R. (Renata), Mäkelä, J. (Johanna), Manios, Y., McDonald, S.W. (Sheila W.), Mommers, M. (Monique), Morgen, C.S. (Camilla S.), Moschonis, G., Murinova, L.P. (Lubica Palkovicova), Newnham, J.P. (John), Nohr, C. (Christian), Andersen, A-M.N. (Anne-Marie Nybo), Oken, E. (Emily), Oostvogels, A.J.J.M. (Adriëtte J. J. M.), Pac, A. (Agnieszka), Papadopoulou, E. (Eleni), Pekkanen, J. (Juha), Pizzi, C. (Costanza), Polanska, K. (Kinga), Porta, D. (Daniela), Richiardi, L. (Lorenzo), Rifas-Shiman, S.L. (Sheryl), Roeleveld, N. (Nel), Santa-Marina, L. (Loreto), Santos, A.C. (Ana Cristina), Smit, H.A. (Henriëtte), Sørensen, T.I.A. (Thorkild), Standl, M. (Marie), Stanislawski, M. (Maggie), Stoltenberg, C. (Camilla), Thiering, E. (Elisabeth), Thijs, C. (Carel), Torrent, M. (Maties), Tough, S.C. (Suzanne C.), Trnovec, T. (Tomáš), Van Gelder, M.M.H.J. (Marleen M. H. J.), Rossem, L. (Lenie) van, Berg, A. (Andrea) von, Vrijheid, M. (Martine), Vrijkotte, T.G.M. (Tanja), Zvinchuk, O. (Oleksandr), Buuren, S. (Stef) van, Jaddoe, V.W.V. (Vincent), Santos, S. (Susana), Eekhout, I. (Iris), Voerman, E. (Ellis), Gaillard, R. (Romy), Barros, A.I. (Ana), Charles, M.A., Chatzi, L. (Leda), Chevrier, C. (Cécile), Chrousos, G.P. (George P.), Corpeleijn, W.E. (Willemijn), Costet, N. (Nathalie), Crozier, S. (Sarah), Doyon, M. (Myriam), Eggesbø, M. (Merete), Fantini, M.P. (Maria), Farchi, S. (Sara), Forastiere, F. (Francesco), Gagliardi, L. (Luigi), Georgiu, V. (Vagelis), Godfrey, K.M. (Keith M.), Gori, D. (Davide), Grote, V. (Veit), Hanke, W. (Wojciech), Hertz-Picciotto, I. (Irva), Heude, B. (Barbara), Hivert, M.-F. (Marie-France), Hryhorczuk, D.O. (Daniel), Huang, R.-C. (Rae-Chi), Inskip, H.M. (Hazel), Jusko, T.A. (Todd A), Karvonen, A.M. (Anne M.), Koletzko, B. (Berthold), Küpers, A.M. (Marlijn), Lagström, H. (Hanna), Lawlor, D.A. (Debbie A.), Lehmann, I. (Irina), Lopez-Espinosa, M.-J. (Maria-Jose), Magnus, P. (Per), Majewska, R. (Renata), Mäkelä, J. (Johanna), Manios, Y., McDonald, S.W. (Sheila W.), Mommers, M. (Monique), Morgen, C.S. (Camilla S.), Moschonis, G., Murinova, L.P. (Lubica Palkovicova), Newnham, J.P. (John), Nohr, C. (Christian), Andersen, A-M.N. (Anne-Marie Nybo), Oken, E. (Emily), Oostvogels, A.J.J.M. (Adriëtte J. J. M.), Pac, A. (Agnieszka), Papadopoulou, E. (Eleni), Pekkanen, J. (Juha), Pizzi, C. (Costanza), Polanska, K. (Kinga), Porta, D. (Daniela), Richiardi, L. (Lorenzo), Rifas-Shiman, S.L. (Sheryl), Roeleveld, N. (Nel), Santa-Marina, L. (Loreto), Santos, A.C. (Ana Cristina), Smit, H.A. (Henriëtte), Sørensen, T.I.A. (Thorkild), Standl, M. (Marie), Stanislawski, M. (Maggie), Stoltenberg, C. (Camilla), Thiering, E. (Elisabeth), Thijs, C. (Carel), Torrent, M. (Maties), Tough, S.C. (Suzanne C.), Trnovec, T. (Tomáš), Van Gelder, M.M.H.J. (Marleen M. H. J.), Rossem, L. (Lenie) van, Berg, A. (Andrea) von, Vrijheid, M. (Martine), Vrijkotte, T.G.M. (Tanja), Zvinchuk, O. (Oleksandr), Buuren, S. (Stef) van, and Jaddoe, V.W.V. (Vincent)

Abstract

Background: Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies. Methods: We used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape. Results: We observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4-17.4) for underweight women, 14.5 kg (11.5-17.7) for normal weight women, 13.9 kg (10.1-17.9) for overweight women, and 11.2 kg (7.0-15.7), 8.7 kg (4.3-13.4) and 6.3 kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy compli

Published
2018
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86. Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium

Author

Felix, J.F. (Janine F.), Joubert, B.R. (Bonnie), Baccarelli, A.A. (Andrea), Sharp, G.C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baïz, N. (Nour), Bakermans-Kranenburg, M.J. (Marian), Bakulski, K.M. (Kelly M.), Binder, E.B. (Elisabeth), Bouchard, L. (Luigi), Breton, C. (Carrie), Brunekreef, B. (Bert), Brunst, K.J. (Kelly J.), Burchard, E.G. (Esteban), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M.C. (Monica Cheng), Corpeleijn, W.E. (Willemijn), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G.D. (George Davey), Boever, P. (Patrick) de, Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (B.), Everson, T.M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M.D. (M. Daniele), Farchi, S. (Sara), Fernandez, M.F. (Mariana), Gao, L. (Lu), Gaunt, T.R. (Tom), Ghantous, A. (Akram), Gillman, M.W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Håberg, S.E. (Siri E), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J.W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D.D. (Dereje D.), Just, A.C. (Allan C.), Karagas, M.R. (Margaret), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K.J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G.H. (Gerard), Küpers, A.M. (Marlijn), Ladd-Acosta, C. (Christine), Lahti, J., Lambrechts, N. (Nathalie), Langie, S.A.S. (Sabine A.S.), Lie, R.T. (Rolv T.), Liu, A.H. (Andrew H.), Magnus, M.C. (Maria C.), Magnus, P. (Per), Maguire, R.L. (Rachel L.), Marsit, C.J. (Carmen J.), McArdle, W.L. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S.K. (Susan K.), Nawrot, T.S. (Tim S.), Nisticò, L. (Lorenza), Nohr, C. (Christian), Nordlund, B. (Björn), Nystad, W. (Wenche), Oh, S.S. (Sam S.), Oken, E. (Emily), Page, C.M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Göran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Räikkönen, K. (Katri), Reese, S.E. (Sarah E.), Reischl, G. (Gunilla), Richiardi, L. (Lorenzo), Ring, S.M. (Susan), Roy, R.P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D.A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sørensen, T.I.A. (Thorkild), Starling, A.P. (Anne P.), Sunyer, J. (Jordi), Taylor, J.A. (Jack A), Tiemeier, H.W. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), IJzendoorn, M.H. (Rien) van, Vonk, J.M. (Judith), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. (Joseph), Wilcox, A.J. (Allen), Wright, R.J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I.V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), London, S.J. (Stephanie J.), Felix, J.F. (Janine F.), Joubert, B.R. (Bonnie), Baccarelli, A.A. (Andrea), Sharp, G.C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baïz, N. (Nour), Bakermans-Kranenburg, M.J. (Marian), Bakulski, K.M. (Kelly M.), Binder, E.B. (Elisabeth), Bouchard, L. (Luigi), Breton, C. (Carrie), Brunekreef, B. (Bert), Brunst, K.J. (Kelly J.), Burchard, E.G. (Esteban), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M.C. (Monica Cheng), Corpeleijn, W.E. (Willemijn), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G.D. (George Davey), Boever, P. (Patrick) de, Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (B.), Everson, T.M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M.D. (M. Daniele), Farchi, S. (Sara), Fernandez, M.F. (Mariana), Gao, L. (Lu), Gaunt, T.R. (Tom), Ghantous, A. (Akram), Gillman, M.W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Håberg, S.E. (Siri E), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J.W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D.D. (Dereje D.), Just, A.C. (Allan C.), Karagas, M.R. (Margaret), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K.J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G.H. (Gerard), Küpers, A.M. (Marlijn), Ladd-Acosta, C. (Christine), Lahti, J., Lambrechts, N. (Nathalie), Langie, S.A.S. (Sabine A.S.), Lie, R.T. (Rolv T.), Liu, A.H. (Andrew H.), Magnus, M.C. (Maria C.), Magnus, P. (Per), Maguire, R.L. (Rachel L.), Marsit, C.J. (Carmen J.), McArdle, W.L. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S.K. (Susan K.), Nawrot, T.S. (Tim S.), Nisticò, L. (Lorenza), Nohr, C. (Christian), Nordlund, B. (Björn), Nystad, W. (Wenche), Oh, S.S. (Sam S.), Oken, E. (Emily), Page, C.M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Göran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Räikkönen, K. (Katri), Reese, S.E. (Sarah E.), Reischl, G. (Gunilla), Richiardi, L. (Lorenzo), Ring, S.M. (Susan), Roy, R.P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D.A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sørensen, T.I.A. (Thorkild), Starling, A.P. (Anne P.), Sunyer, J. (Jordi), Taylor, J.A. (Jack A), Tiemeier, H.W. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), IJzendoorn, M.H. (Rien) van, Vonk, J.M. (Judith), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. (Joseph), Wilcox, A.J. (Allen), Wright, R.J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I.V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), and London, S.J. (Stephanie J.)

Published
2018
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87. Maternal and fetal genetic contribution to gestational weight gain

Author

Warrington, N.M. (N. M.), Richmond, R.C. (Rebecca C.), Fenstra, B. (B.), Myhre, R. (Ronny), Gaillard, R. (Romy), Paternoster, L. (L.), Wang, C.A. (C. A.), Beaumont, R.N. (R. N.), Das, S. (Shikta), Murcia, M. (Mario), Barton, S.J. (Sheila), Espinosa, A. (A.), Thiering, E. (Elisabeth), Atalay, M. (Mustafa), Pitkanen, N. (Niina), Ntalla, I. (Ioanna), Jonsson, A.E. (A. E.), Freathy, R.M. (Rachel), Karhunen, V. (V.), Tiesler, C.M.T. (C. M.T.), Allard, C. (Catherine), Crawford, A. (A.), Ring, S.M. (Susan), Melbye, M. (Mads), Magnus, P. (Per), Rivadeneira, F. (F.), Skotte, L. (L.), Hansen, T. (Torben), Marsh, J.A. (Julie), Guxens Junyent, M. (Mònica), Holloway, J.W. (J. W.), Grallert, H. (Harald), Jaddoe, V.W.V. (Vincent), Lowe, W.L. (W. L.), Roumeliotaki, T. (Theano), Hattersley, A.T. (Andrew), Lindi, V. (Virpi), Pahkala, K. (Katja), Panoutsopoulou, K. (K.), Standl, M. (M.), Flexeder, C. (Claudia), Bouchard, L. (Luigi), Aagaard Nohr, E. (E.), Santa-Marina, L. (Loreto), Kogevinas, M. (Manolis), Niinikoski, H. (H.), Dedoussis, G.V. (George), Heinrich, J. (J.), Reynolds, R.M. (Rebecca), Lakka, T.A. (Timo), Zeggini, E. (Eleftheria), Raitakari, O.T. (O. T.), Chatzi, L. (Leda), Inskip, H.M. (Hazel), Bustamante, M. (Mariona), Hivert, M.-F. (Marie-France), Jarvelin, M.-R. (M. R.), Sørensen, T.I.A. (Thorkild), Pennell, C.E. (Craig), Felix, J.F. (J. F.), Jacobsson, B. (B.), Geller, F. (Frank), Evans, D.M. (D. M.), Lawlor, D.A. (D. A.), Warrington, N.M. (N. M.), Richmond, R.C. (Rebecca C.), Fenstra, B. (B.), Myhre, R. (Ronny), Gaillard, R. (Romy), Paternoster, L. (L.), Wang, C.A. (C. A.), Beaumont, R.N. (R. N.), Das, S. (Shikta), Murcia, M. (Mario), Barton, S.J. (Sheila), Espinosa, A. (A.), Thiering, E. (Elisabeth), Atalay, M. (Mustafa), Pitkanen, N. (Niina), Ntalla, I. (Ioanna), Jonsson, A.E. (A. E.), Freathy, R.M. (Rachel), Karhunen, V. (V.), Tiesler, C.M.T. (C. M.T.), Allard, C. (Catherine), Crawford, A. (A.), Ring, S.M. (Susan), Melbye, M. (Mads), Magnus, P. (Per), Rivadeneira, F. (F.), Skotte, L. (L.), Hansen, T. (Torben), Marsh, J.A. (Julie), Guxens Junyent, M. (Mònica), Holloway, J.W. (J. W.), Grallert, H. (Harald), Jaddoe, V.W.V. (Vincent), Lowe, W.L. (W. L.), Roumeliotaki, T. (Theano), Hattersley, A.T. (Andrew), Lindi, V. (Virpi), Pahkala, K. (Katja), Panoutsopoulou, K. (K.), Standl, M. (M.), Flexeder, C. (Claudia), Bouchard, L. (Luigi), Aagaard Nohr, E. (E.), Santa-Marina, L. (Loreto), Kogevinas, M. (Manolis), Niinikoski, H. (H.), Dedoussis, G.V. (George), Heinrich, J. (J.), Reynolds, R.M. (Rebecca), Lakka, T.A. (Timo), Zeggini, E. (Eleftheria), Raitakari, O.T. (O. T.), Chatzi, L. (Leda), Inskip, H.M. (Hazel), Bustamante, M. (Mariona), Hivert, M.-F. (Marie-France), Jarvelin, M.-R. (M. R.), Sørensen, T.I.A. (Thorkild), Pennell, C.E. (Craig), Felix, J.F. (J. F.), Jacobsson, B. (B.), Geller, F. (Frank), Evans, D.M. (D. M.), and Lawlor, D.A. (D. A.)

Abstract

Background:Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG.Participants and methods:A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional analyses determined the proportion of variability in GWG from maternal and fetal common genetic variants and the overlap of established genome-wide significant variants for phenotypes relevant to GWG (for example, maternal body mass index (BMI) and glucose, birth weight).Results:Approximately 20% of the variability in GWG was tagged by common maternal genetic variants, and the fetal genome made a surprisingly minor contribution to explain variation in GWG. Variants near the pregnancy-specific beta-1 glycoprotein 5 (PSG5) gene reached genome-wide significance (P=1.71 × 10 â '8) for total GWG in the offspring genome, but did not replicate. Some established variants associated with increased BMI, fasting glucose and type 2 diabetes were associated with lower early, and higher later GWG. Maternal variants related to higher systolic blood pressure were related to lower late GWG. Established maternal and fetal birth weight variants were largely unrelated to GWG.Conclusions:We found a modest contribution of maternal common variants to GWG and some overlap of maternal BMI, glucose and type 2 diabetes variants with GWG. These findings suggest that associations between GWG and later offspring/maternal outc

Published
2018
Full Text
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88. Maternal and fetal genetic contribution to gestational weight gain

Author

Warrington, N. M. (N. M.), Richmond, R. (R.), Fenstra, B. (B.), Myhre, R. (R.), Gaillard, R. (R.), Paternoster, L. (L.), Wang, C. A. (C. A.), Beaumont, R. N. (R. N.), Das, S. (S.), Murcia, M. (M.), Barton, S. J. (S. J.), Espinosa, A. (A.), Thiering, E. (E.), Atalay, M. (M.), Pitkanen, N. (N.), Ntalla, I. (I.), Jonsson, A. E. (A. E.), Freathy, R. (R.), Karhunen, V. (V.), Tiesler, C. M. (C. M. T.), Allard, C. (C.), Crawford, A. (A.), Ring, S. M. (S. M.), Melbye, M. (M.), Magnus, P. (P.), Rivadeneira, F. (F.), Skotte, L. (L.), Hansen, T. (T.), Marsh, J. (J.), Guxens, M. (M.), Holloway, J. W. (J. W.), Grallert, H. (H.), Jaddoe, V. W. (V. W. V.), Lowe, W. L. (W. L.), Roumeliotaki, T. (T.), Hattersley, A. T. (A. T.), Lindi, V. (V.), Pahkala, K. (K.), Panoutsopoulou, K. (K.), Standl, M. (M.), Flexeder, C. (C.), Bouchard, L. (L.), Aagaard Nohr, E. (E.), Santa Marina, L. (L.), Kogevinas, M. (M.), Niinikoski, H. (H.), Dedoussis, G. (G.), Heinrich, J. (J.), Reynolds, R. M. (R. M.), Lakka, T. (T.), Zeggini, E. (E.), Raitakari, O. T. (O. T.), Chatzi, L. (L.), Inskip, H. M. (H. M.), Bustamante, M. (M.), Hivert, M.-F. (M-F), Järvelin, M.-R. (M-R), Sorensen, T. I. (T. I. A.), Pennell, C. (C.), Felix, J. F. (J. F.), Jacobsson, B. (B.), Geller, F. (F.), Evans, D. M. (D. M.), Lawlor, D. A. (D. A.), Warrington, N. M. (N. M.), Richmond, R. (R.), Fenstra, B. (B.), Myhre, R. (R.), Gaillard, R. (R.), Paternoster, L. (L.), Wang, C. A. (C. A.), Beaumont, R. N. (R. N.), Das, S. (S.), Murcia, M. (M.), Barton, S. J. (S. J.), Espinosa, A. (A.), Thiering, E. (E.), Atalay, M. (M.), Pitkanen, N. (N.), Ntalla, I. (I.), Jonsson, A. E. (A. E.), Freathy, R. (R.), Karhunen, V. (V.), Tiesler, C. M. (C. M. T.), Allard, C. (C.), Crawford, A. (A.), Ring, S. M. (S. M.), Melbye, M. (M.), Magnus, P. (P.), Rivadeneira, F. (F.), Skotte, L. (L.), Hansen, T. (T.), Marsh, J. (J.), Guxens, M. (M.), Holloway, J. W. (J. W.), Grallert, H. (H.), Jaddoe, V. W. (V. W. V.), Lowe, W. L. (W. L.), Roumeliotaki, T. (T.), Hattersley, A. T. (A. T.), Lindi, V. (V.), Pahkala, K. (K.), Panoutsopoulou, K. (K.), Standl, M. (M.), Flexeder, C. (C.), Bouchard, L. (L.), Aagaard Nohr, E. (E.), Santa Marina, L. (L.), Kogevinas, M. (M.), Niinikoski, H. (H.), Dedoussis, G. (G.), Heinrich, J. (J.), Reynolds, R. M. (R. M.), Lakka, T. (T.), Zeggini, E. (E.), Raitakari, O. T. (O. T.), Chatzi, L. (L.), Inskip, H. M. (H. M.), Bustamante, M. (M.), Hivert, M.-F. (M-F), Järvelin, M.-R. (M-R), Sorensen, T. I. (T. I. A.), Pennell, C. (C.), Felix, J. F. (J. F.), Jacobsson, B. (B.), Geller, F. (F.), Evans, D. M. (D. M.), and Lawlor, D. A. (D. A.)

Abstract

Background: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. Participants and methods: A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional analyses determined the proportion of variability in GWG from maternal and fetal common genetic variants and the overlap of established genome-wide significant variants for phenotypes relevant to GWG (for example, maternal body mass index (BMI) and glucose, birth weight). Results: Approximately 20% of the variability in GWG was tagged by common maternal genetic variants, and the fetal genome made a surprisingly minor contribution to explain variation in GWG. Variants near the pregnancy-specific beta-1 glycoprotein 5 (PSG5) gene reached genome-wide significance (P=1.71 × 10−8) for total GWG in the offspring genome, but did not replicate. Some established variants associated with increased BMI, fasting glucose and type 2 diabetes were associated with lower early, and higher later GWG. Maternal variants related to higher systolic blood pressure were related to lower late GWG. Established maternal and fetal birth weight variants were largely unrelated to GWG. Conclusions: We found a modest contribution of maternal common variants to GWG and some overlap of maternal BMI, glucose and type 2 diabetes variants with GWG. These findings suggest that associations between GWG and later offspring

Published
2018

89. Cohort profile:pregnancy and childhood epigenetics (PACE) consortium

Author

Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. (Wenche), Oh, S. S. (Sam S.), Oken, E. (Emily), Page, C. M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Goran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Raikkonen, K. (Katri), Reese, S. E. (Sarah E.), Reischl, E. (Eva), Richiardi, L. (Lorenzo), Ring, S. (Susan), Roy, R. P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D. A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sorensen, T. I. (Thorkild I. A.), Starling, A. P. (Anne P.), Sunyer, J. (Jordi), ATaylor, J. (Jack), Tiemeier, H. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), Van Ijzendoorn, M. H. (Marinus H.), Vonk, J. M. (Judith M.), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. L. (Joseph L.), Wilcox, A. J. (Allen J.), Wright, R. J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I. V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C. L. (Caroline L.), Jaddoe, V. W. (Vincent W. V.), London, S. J. (Stephanie J.), Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. (Wenche), Oh, S. S. (Sam S.), Oken, E. (Emily), Page, C. M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Goran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Raikkonen, K. (Katri), Reese, S. E. (Sarah E.), Reischl, E. (Eva), Richiardi, L. (Lorenzo), Ring, S. (Susan), Roy, R. P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D. A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sorensen, T. I. (Thorkild I. A.), Starling, A. P. (Anne P.), Sunyer, J. (Jordi), ATaylor, J. (Jack), Tiemeier, H. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), Van Ijzendoorn, M. H. (Marinus H.), Vonk, J. M. (Judith M.), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. L. (Joseph L.), Wilcox, A. J. (Allen J.), Wright, R. J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I. V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C. L. (Caroline L.), Jaddoe, V. W. (Vincent W. V.), and London, S. J. (Stephanie J.)

Published
2018

90. Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Author

Beaumont, R. N. (Robin N.), Warrington, N. M. (Nicole M.), Cavadino, A. (Alana), Tyrrell, J. (Jessica), Nodzenski, M. (Michael), Horikoshi, M. (Momoko), Geller, F. (Frank), Myhre, R. (Ronny), Richmond, R. C. (Rebecca C.), Paternoster, L. (Lavinia), Bradfield, J. P. (Jonathan P.), Kreiner-Moller, E. (Eskil), Huikari, V. (Ville), Metrustry, S. (Sarah), Lunetta, K. L. (Kathryn L.), Painter, J. N. (Jodie N.), Hottenga, J.-J. (Jouke-Jan), Allard, C. (Catherine), Barton, S. J. (Sheila J.), Espinosa, A. (Ana), Marsh, J. A. (Julie A.), Potter, C. (Catherine), Zhang, G. (Ge), Ang, W. (Wei), Berry, D. J. (Diane J.), Bouchard, L. (Luigi), Das, S. (Shikta), Hakonarson, H. (Hakon), Heikkinen, J. (Jani), Helgeland, O. (Oyvind), Hocher, B. (Berthold), Hofman, A. (Albert), Inskip, H. M. (Hazel M.), Jones, S. E. (Samuel E.), Kogevinas, M. (Manolis), Lind, P. A. (Penelope A.), Marullo, L. (Letizia), Medland, S. E. (Sarah E.), Murray, A. (Anna), Murray, J. C. (Jeffrey C.), Njolstad, P. R. (Pal R.), Nohr, E. A. (Ellen A.), Reichetzeder, C. (Christoph), Ring, S. M. (Susan M.), Ruth, K. S. (Katherine S.), Santa-Marina, L. (Loreto), Scholtens, D. M. (Denise M.), Sebert, S. (Sylvain), Sengpiel, V. (Verena), Tuke, M. A. (Marcus A.), Vaudel, M. (Marc), Weedon, M. N. (Michael N.), Willemsen, G. (Gonneke), Wood, A. R. (Andrew R.), Yaghootkar, H. (Hanieh), Muglia, L. J. (Louis J.), Bartels, M. (Meike), Relton, C. L. (Caroline L.), Pennell, C. E. (Craig E.), Chatzi, L. (Leda), Estivill, X. (Xavier), Holloway, J. W. (John W.), Boomsma, D. I. (Dorret I.), Montgomery, G. W. (Grant W.), Murabito, J. M. (Joanne M.), Spector, T. D. (Tim D.), Power, C. (Christine), Järvelin, M.-R. (Marjo-Ritta), Bisgaard, H. (Hans), Grant, S. F. (Struan F. A.), Sorensen, T. I. (Thorkild I. A.), Jaddoe, V. W. (Vincent W.), Jacobsson, B. (Bo), Melbye, M. (Mads), McCarthy, M. I. (Mark I.), Hattersley, A. T. (Andrew T.), Hayes, M. G. (M. Geoffrey), Frayling, T. M. (Timothy M.), Hivert, M.-F. (Marie-France), Felix, J. F. (Janine F.), Hypponen, E. (Elina), Lowe, W. L. (William L., Jr.), Evans, D. M. (David M.), Lawlor, D. A. (Debbie A.), Feenstra, B. (Bjarke), Freathy, R. M. (Rachel M.), Beaumont, R. N. (Robin N.), Warrington, N. M. (Nicole M.), Cavadino, A. (Alana), Tyrrell, J. (Jessica), Nodzenski, M. (Michael), Horikoshi, M. (Momoko), Geller, F. (Frank), Myhre, R. (Ronny), Richmond, R. C. (Rebecca C.), Paternoster, L. (Lavinia), Bradfield, J. P. (Jonathan P.), Kreiner-Moller, E. (Eskil), Huikari, V. (Ville), Metrustry, S. (Sarah), Lunetta, K. L. (Kathryn L.), Painter, J. N. (Jodie N.), Hottenga, J.-J. (Jouke-Jan), Allard, C. (Catherine), Barton, S. J. (Sheila J.), Espinosa, A. (Ana), Marsh, J. A. (Julie A.), Potter, C. (Catherine), Zhang, G. (Ge), Ang, W. (Wei), Berry, D. J. (Diane J.), Bouchard, L. (Luigi), Das, S. (Shikta), Hakonarson, H. (Hakon), Heikkinen, J. (Jani), Helgeland, O. (Oyvind), Hocher, B. (Berthold), Hofman, A. (Albert), Inskip, H. M. (Hazel M.), Jones, S. E. (Samuel E.), Kogevinas, M. (Manolis), Lind, P. A. (Penelope A.), Marullo, L. (Letizia), Medland, S. E. (Sarah E.), Murray, A. (Anna), Murray, J. C. (Jeffrey C.), Njolstad, P. R. (Pal R.), Nohr, E. A. (Ellen A.), Reichetzeder, C. (Christoph), Ring, S. M. (Susan M.), Ruth, K. S. (Katherine S.), Santa-Marina, L. (Loreto), Scholtens, D. M. (Denise M.), Sebert, S. (Sylvain), Sengpiel, V. (Verena), Tuke, M. A. (Marcus A.), Vaudel, M. (Marc), Weedon, M. N. (Michael N.), Willemsen, G. (Gonneke), Wood, A. R. (Andrew R.), Yaghootkar, H. (Hanieh), Muglia, L. J. (Louis J.), Bartels, M. (Meike), Relton, C. L. (Caroline L.), Pennell, C. E. (Craig E.), Chatzi, L. (Leda), Estivill, X. (Xavier), Holloway, J. W. (John W.), Boomsma, D. I. (Dorret I.), Montgomery, G. W. (Grant W.), Murabito, J. M. (Joanne M.), Spector, T. D. (Tim D.), Power, C. (Christine), Järvelin, M.-R. (Marjo-Ritta), Bisgaard, H. (Hans), Grant, S. F. (Struan F. A.), Sorensen, T. I. (Thorkild I. A.), Jaddoe, V. W. (Vincent W.), Jacobsson, B. (Bo), Melbye, M. (Mads), McCarthy, M. I. (Mark I.), Hattersley, A. T. (Andrew T.), Hayes, M. G. (M. Geoffrey), Frayling, T. M. (Timothy M.), Hivert, M.-F. (Marie-France), Felix, J. F. (Janine F.), Hypponen, E. (Elina), Lowe, W. L. (William L., Jr.), Evans, D. M. (David M.), Lawlor, D. A. (Debbie A.), Feenstra, B. (Bjarke), and Freathy, R. M. (Rachel M.)

Abstract

Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86 577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother–child pairs to quantify the separate maternal and fetal genetic effects. Maternal SNPs at 10 loci (MTNR1B, HMGA2, SH2B3, KCNAB1, L3MBTL3, GCK, EBF1, TCF7L2, ACTL9, CYP3A7) were associated with offspring birth weight at P < 5 × 10−8. In SEM analyses, at least 7 of the 10 associations were consistent with effects of the maternal genotype acting via the intrauterine environment, rather than via effects of shared alleles with the fetus. Variants, or correlated proxies, at many of the loci had been previously associated with adult traits, including fasting glucose (MTNR1B, GCK and TCF7L2) and sex hormone levels (CYP3A7), and one (EBF1) with gestational duration. The identified associations indicate that genetic effects on maternal glucose, cytochrome P450 activity and gestational duration, and potentially on maternal blood pressure and immune function, are relevant for fetal growth. Further characterization of these associations in mechanistic and causal analyses will enhance understanding of the potentially modifiable maternal determinants of fetal growth, with the goal of reducing the morbidity and mortality associated with low and high birth weights.

Published
2018

91. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

Author

Contreras, Z.A., Chen, Z., Roumeliotaki, T., Annesi-Maesano, I., Baïz, N., von Berg, A., Bergström, A., Crozier, S., Duijts, L., Ekström, S., Eller, E., Fantini, M.P., Kjaer, H.F., Forastiere, F., Gerhard, B., Gori, D., Harskamp-van Ginkel, M.W., Heinrich, J., Iñiguez, C., Inskip, H., Keil, T., Kogevinas, M., Lau, S., Lehmann, Irina, Maier, D., van Meel, E.R., Mommers, M., Murcia, M., Porta, D., Smit, H.A., Standl, M., Stratakis, N., Sunyer, J., Thijs, C., Torrent, M., Vrijkotte, T.G.M., Wijga, A.H., Berhane, K., Gilliland, F., Chatzi, L., Contreras, Z.A., Chen, Z., Roumeliotaki, T., Annesi-Maesano, I., Baïz, N., von Berg, A., Bergström, A., Crozier, S., Duijts, L., Ekström, S., Eller, E., Fantini, M.P., Kjaer, H.F., Forastiere, F., Gerhard, B., Gori, D., Harskamp-van Ginkel, M.W., Heinrich, J., Iñiguez, C., Inskip, H., Keil, T., Kogevinas, M., Lau, S., Lehmann, Irina, Maier, D., van Meel, E.R., Mommers, M., Murcia, M., Porta, D., Smit, H.A., Standl, M., Stratakis, N., Sunyer, J., Thijs, C., Torrent, M., Vrijkotte, T.G.M., Wijga, A.H., Berhane, K., Gilliland, F., and Chatzi, L.

Abstract

The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3–4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3–4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18–2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31–3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08–2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.

Published
2018

92. Early childhood asthma and the risk of new onset obesity: An individual participant meta-analysis of 16 European birth cohorts

Author

Contreras, Z., Chen, Z., Roumeliotaki, T., Annesi-Maesano, I., Baiz, N., von Berg, A., Bergstrom, A., Bindslev-Jensen, C., Crozier, S., Duijts, L., Ekstrom, S., Eller, E., Fantini, M., Forastiere, F., Gerhard, B., Gori, D., Harskamp-van Ginkel, M., Heinrich, J., Iñiguez, C., Inskip, H., Keil, T., Kogevinas, M., Lau, S., Lehmann, Irina, Maier, D., van Meel, E., Mommers, M., Murcia, M., Porta, D., Smit, H., Standl, M., Stratakis, N., Sunyer, J., Thijs, C., Torrent, M., Vrijkotte, T., Wijga, A., Berhane, K., Gilliland, F., Chatzi, L., Contreras, Z., Chen, Z., Roumeliotaki, T., Annesi-Maesano, I., Baiz, N., von Berg, A., Bergstrom, A., Bindslev-Jensen, C., Crozier, S., Duijts, L., Ekstrom, S., Eller, E., Fantini, M., Forastiere, F., Gerhard, B., Gori, D., Harskamp-van Ginkel, M., Heinrich, J., Iñiguez, C., Inskip, H., Keil, T., Kogevinas, M., Lau, S., Lehmann, Irina, Maier, D., van Meel, E., Mommers, M., Murcia, M., Porta, D., Smit, H., Standl, M., Stratakis, N., Sunyer, J., Thijs, C., Torrent, M., Vrijkotte, T., Wijga, A., Berhane, K., Gilliland, F., and Chatzi, L.

Abstract

no abstract

Published
2018

93. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author

Santos, S., Eekhout, I., Voerman, I., Gaillard, R., Barros, H., Charles, M.-A., Chatzi, L., Chevrier, C., Chrousos, G.P., Corpeleijn, E., Costet, N., Crozier, S., Doyon, M., Eggesbø, M., Fantini, M.P., Farchi, S., Forastiere, F., Gagliardi, L., Georgiu, V., Godfrey, K.M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M.-F., Hryhorczuk, D., Huang, R.-C., Inskip, H., Jusko, T.A., Karvonen, A.M., Koletzko, B., Küpers, L.K., Lagström, H., Lawlor, D.A., Lehmann, Irina, Lopez-Espinosa, M.-J., Magnus, P., Majewska, R., Mäkelä, J., Manios, Y., McDonald, S.W., Mommers, M., Morgen, C.S., Moschonis, G., Murínová, L., Newnham, J., Nohr, E.A., Nybo Andersen, A.-M., Oken, E., Oostvogels, A.J.J.M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S.-L., Roeleveld, N., Santa-Marina, L., Santos, A.C., Smit, H.A., Sørensen, T.I.A., Standl, M., Stanislawski, M., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S.C., Trnovec, T., van Gelder, M.M.H.J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T.G.M., Zvinchuk, O., van Buuren, S., Jaddoe, V.W.V., Santos, S., Eekhout, I., Voerman, I., Gaillard, R., Barros, H., Charles, M.-A., Chatzi, L., Chevrier, C., Chrousos, G.P., Corpeleijn, E., Costet, N., Crozier, S., Doyon, M., Eggesbø, M., Fantini, M.P., Farchi, S., Forastiere, F., Gagliardi, L., Georgiu, V., Godfrey, K.M., Gori, D., Grote, V., Hanke, W., Hertz-Picciotto, I., Heude, B., Hivert, M.-F., Hryhorczuk, D., Huang, R.-C., Inskip, H., Jusko, T.A., Karvonen, A.M., Koletzko, B., Küpers, L.K., Lagström, H., Lawlor, D.A., Lehmann, Irina, Lopez-Espinosa, M.-J., Magnus, P., Majewska, R., Mäkelä, J., Manios, Y., McDonald, S.W., Mommers, M., Morgen, C.S., Moschonis, G., Murínová, L., Newnham, J., Nohr, E.A., Nybo Andersen, A.-M., Oken, E., Oostvogels, A.J.J.M., Pac, A., Papadopoulou, E., Pekkanen, J., Pizzi, C., Polanska, K., Porta, D., Richiardi, L., Rifas-Shiman, S.-L., Roeleveld, N., Santa-Marina, L., Santos, A.C., Smit, H.A., Sørensen, T.I.A., Standl, M., Stanislawski, M., Stoltenberg, C., Thiering, E., Thijs, C., Torrent, M., Tough, S.C., Trnovec, T., van Gelder, M.M.H.J., van Rossem, L., von Berg, A., Vrijheid, M., Vrijkotte, T.G.M., Zvinchuk, O., van Buuren, S., and Jaddoe, V.W.V.

Abstract

BackgroundGestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies.MethodsWe used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape.ResultsWe observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4–17.4) for underweight women, 14.5 kg (11.5–17.7) for normal weight women, 13.9 kg (10.1–17.9) for overweight women, and 11.2 kg (7.0–15.7), 8.7 kg (4.3–13.4) and 6.3 kg (1.9–11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain pat

Published
2018

94. Maternal and fetal genetic contribution to gestational weight gain

Author

Warrington, N M, Richmond, R, Fenstra, B, Myhre, R, Gaillard, R, Paternoster, L, Wang, C A, Beaumont, R N, Das, S, Murcia, M, Barton, S J, Espinosa, A, Thiering, E, Atalay, M, Pitkänen, N, Ntalla, I, Jonsson, A E, Freathy, R, Karhunen, V, Tiesler, C M T, Allard, C, Crawford, A, Ring, S M, Melbye, M, Magnus, P, Rivadeneira, F, Skotte, L, Hansen, T, Marsh, J, Guxens, M, Holloway, J W, Grallert, H, Jaddoe, V W V, Lowe, W L, Roumeliotaki, T, Hattersley, A T, Lindi, V, Pahkala, K, Panoutsopoulou, K, Standl, M, Flexeder, C, Bouchard, L, Aagaard Nohr, E, Marina, L Santa, Kogevinas, M, Niinikoski, H, Dedoussis, G, Heinrich, J, Reynolds, R M, Lakka, T, Zeggini, E, Raitakari, O T, Chatzi, L, Inskip, H M, Bustamante, M, Hivert, M-F, Jarvelin, M-R, Sørensen, T I A, Pennell, C, Felix, J F, Jacobsson, B, Geller, F, Evans, D M, Lawlor, D A, Warrington, N M, Richmond, R, Fenstra, B, Myhre, R, Gaillard, R, Paternoster, L, Wang, C A, Beaumont, R N, Das, S, Murcia, M, Barton, S J, Espinosa, A, Thiering, E, Atalay, M, Pitkänen, N, Ntalla, I, Jonsson, A E, Freathy, R, Karhunen, V, Tiesler, C M T, Allard, C, Crawford, A, Ring, S M, Melbye, M, Magnus, P, Rivadeneira, F, Skotte, L, Hansen, T, Marsh, J, Guxens, M, Holloway, J W, Grallert, H, Jaddoe, V W V, Lowe, W L, Roumeliotaki, T, Hattersley, A T, Lindi, V, Pahkala, K, Panoutsopoulou, K, Standl, M, Flexeder, C, Bouchard, L, Aagaard Nohr, E, Marina, L Santa, Kogevinas, M, Niinikoski, H, Dedoussis, G, Heinrich, J, Reynolds, R M, Lakka, T, Zeggini, E, Raitakari, O T, Chatzi, L, Inskip, H M, Bustamante, M, Hivert, M-F, Jarvelin, M-R, Sørensen, T I A, Pennell, C, Felix, J F, Jacobsson, B, Geller, F, Evans, D M, and Lawlor, D A

Abstract

BACKGROUND: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG.PARTICIPANTS AND METHODS: A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional analyses determined the proportion of variability in GWG from maternal and fetal common genetic variants and the overlap of established genome-wide significant variants for phenotypes relevant to GWG (for example, maternal body mass index (BMI) and glucose, birth weight).RESULTS: Approximately 20% of the variability in GWG was tagged by common maternal genetic variants, and the fetal genome made a surprisingly minor contribution to explain variation in GWG. Variants near the pregnancy-specific beta-1 glycoprotein 5 (PSG5) gene reached genome-wide significance (P=1.71 × 10-8) for total GWG in the offspring genome, but did not replicate. Some established variants associated with increased BMI, fasting glucose and type 2 diabetes were associated with lower early, and higher later GWG. Maternal variants related to higher systolic blood pressure were related to lower late GWG. Established maternal and fetal birth weight variants were largely unrelated to GWG.CONCLUSIONS: We found a modest contribution of maternal common variants to GWG and some overlap of maternal BMI, glucose and type 2 diabetes variants with GWG. These findings suggest that associations between GWG and late

Published
2018

95. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

Author

Contreras, ZA, Chen, ZH, Roumeliotaki, T, Annesi-Maesano, I, Baiz, N, Berg, A, Bergstrom, A, Crozier, S, Duijts, Liesbeth, Ekstrom, S, Eller, E, Fantini, MP, Kjaer, HF, Forastiere, F, Gerhard, B, Gori, D, Harskamp-van Ginkel, MW, Heinrich, J, Iniguez, C, Inskip, H, Keil, T, Kogevinas, M, Lau, S, Lehmann, I, Maier, D, van Meel, Evelien, Mommers, M, Murcia, M, Porta, D, Smit, HA, Standl, M, Stratakis, N, Sunyer, J, Thijs, C, Torrent, M, Vrijkotte, TGM, Wijga, AH, Berhane, K, Gilliland, F, Chatzi, L, Contreras, ZA, Chen, ZH, Roumeliotaki, T, Annesi-Maesano, I, Baiz, N, Berg, A, Bergstrom, A, Crozier, S, Duijts, Liesbeth, Ekstrom, S, Eller, E, Fantini, MP, Kjaer, HF, Forastiere, F, Gerhard, B, Gori, D, Harskamp-van Ginkel, MW, Heinrich, J, Iniguez, C, Inskip, H, Keil, T, Kogevinas, M, Lau, S, Lehmann, I, Maier, D, van Meel, Evelien, Mommers, M, Murcia, M, Porta, D, Smit, HA, Standl, M, Stratakis, N, Sunyer, J, Thijs, C, Torrent, M, Vrijkotte, TGM, Wijga, AH, Berhane, K, Gilliland, F, and Chatzi, L

Published
2018

96. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author

Moreira da Silva Santos, Susana, Eekhout, I, Voerman, Ellis, Gaillard, Romy, Barros, H, Charles, MA, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costet, N, Crozier, S, Doyon, M, Eggesbo, M, Fantini, MP, Farchi, S, Forastiere, F, Gagliardi, L, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, MF, Hryhorczuk, D, Huang, RC, Inskip, H, Jusko, TA, Karvonen, AM, Koletzko, B, Kupers, LK, Lagstrom, H, Lawlor, DA, Lehmann, I, Lopez-Espinosa, MJ, Magnus, P, Majewska, R, Makela, J, Manios, Y, McDonald, SW, Mommers, M, Morgen, CS, Moschonis, G, Murinova, L, Newnham, J, Nohr, EA, Andersen, AMN, Oken, E, Oostvogels, A, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Santa-Marina, L, dos Santos, AC, Smit, HA, Sorensen, TIA, Standl, M, Stanislawski, M, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Gelder, M, Rossem, L, Berg, A, Vrijheid, M, Vrijkotte, TGM, Zvinchuk, O, van Buuren, S, Jaddoe, Vincent, Moreira da Silva Santos, Susana, Eekhout, I, Voerman, Ellis, Gaillard, Romy, Barros, H, Charles, MA, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costet, N, Crozier, S, Doyon, M, Eggesbo, M, Fantini, MP, Farchi, S, Forastiere, F, Gagliardi, L, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, MF, Hryhorczuk, D, Huang, RC, Inskip, H, Jusko, TA, Karvonen, AM, Koletzko, B, Kupers, LK, Lagstrom, H, Lawlor, DA, Lehmann, I, Lopez-Espinosa, MJ, Magnus, P, Majewska, R, Makela, J, Manios, Y, McDonald, SW, Mommers, M, Morgen, CS, Moschonis, G, Murinova, L, Newnham, J, Nohr, EA, Andersen, AMN, Oken, E, Oostvogels, A, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Santa-Marina, L, dos Santos, AC, Smit, HA, Sorensen, TIA, Standl, M, Stanislawski, M, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Gelder, M, Rossem, L, Berg, A, Vrijheid, M, Vrijkotte, TGM, Zvinchuk, O, van Buuren, S, and Jaddoe, Vincent

Published
2018

97. Maternal and fetal genetic contribution to gestational weight gain

Author

Warrington, NM, Richmond, R, Fenstra, B, Myhre, R, Gaillard, Romy, Paternoster, L, Wang, CA, Beaumont, RN, Das, S, Murcia, M, Barton, SJ, Espinosa, A, Thiering, E, Atalay, M, Pitkanen, N, Ntalla, I, Jonsson, AE, Freathy, R, Karhunen, V, Tiesler, CMT, Allard, C, Crawford, A, Ring, SM, Melbye, M, Magnus, P, Rivadeneira, Fernando, Skotte, L, Hansen, T, Marsh, J, Guxens Junyent, Monica, Holloway, JW, Grallert, H, Jaddoe, Vincent, Lowe, WL, Roumeliotaki, T, Hattersley, AT, Lindi, V, Pahkala, K, Panoutsopoulou, K, Standl, M, Flexeder, C, Bouchard, L, Nohr, E, Marina, L, Kogevinas, M, Niinikoski, H, Dedoussis, G, Heinrich, J, Reynolds, RM, Lakka, T, Zeggini, E, Raitakari, OT, Chatzi, L, Inskip, HM, Bustamante, M, Hivert, MF, Jarvelin, MR, Sorensen, TIA, Pennell, C, Felix, Janine, Jacobsson, B, Geller, F, Evans, DM, Lawlor, DA, Warrington, NM, Richmond, R, Fenstra, B, Myhre, R, Gaillard, Romy, Paternoster, L, Wang, CA, Beaumont, RN, Das, S, Murcia, M, Barton, SJ, Espinosa, A, Thiering, E, Atalay, M, Pitkanen, N, Ntalla, I, Jonsson, AE, Freathy, R, Karhunen, V, Tiesler, CMT, Allard, C, Crawford, A, Ring, SM, Melbye, M, Magnus, P, Rivadeneira, Fernando, Skotte, L, Hansen, T, Marsh, J, Guxens Junyent, Monica, Holloway, JW, Grallert, H, Jaddoe, Vincent, Lowe, WL, Roumeliotaki, T, Hattersley, AT, Lindi, V, Pahkala, K, Panoutsopoulou, K, Standl, M, Flexeder, C, Bouchard, L, Nohr, E, Marina, L, Kogevinas, M, Niinikoski, H, Dedoussis, G, Heinrich, J, Reynolds, RM, Lakka, T, Zeggini, E, Raitakari, OT, Chatzi, L, Inskip, HM, Bustamante, M, Hivert, MF, Jarvelin, MR, Sorensen, TIA, Pennell, C, Felix, Janine, Jacobsson, B, Geller, F, Evans, DM, and Lawlor, DA

Published
2018

98. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author

Felix, Janine, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baiz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Munthe-Kaas, MC, Corpeleijn, E, Czamara, D, Dabelea, D, Smith, GD, De Boever, P, Duijts, Liesbeth, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Haberg, SE, Herceg, Z, Hivert, MF, Holland, N, Holloway, JW, Hoyo, C, Hu, DL, Huang, RC, Huen, K, Jarvelin, MR, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Kupers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melen, E, Melton, P, Murphy, SK, Nawrot, TS, Nistico, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sorensen, TIA, Starling, AP, Sunyer, J, Ataylor, J, Tiemeier, Henning, Ullemar, V, Vafeiadi, M, van IJzendoorn, Marinus, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, CJ, Xu, ZL, Yang, IV, Yousefi, P, Zhang, HM, Zhang, WM, Zhao, SS, Agha, G, Relton, CL, Jaddoe, Vincent, London, SJ, Felix, Janine, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baiz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Munthe-Kaas, MC, Corpeleijn, E, Czamara, D, Dabelea, D, Smith, GD, De Boever, P, Duijts, Liesbeth, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Haberg, SE, Herceg, Z, Hivert, MF, Holland, N, Holloway, JW, Hoyo, C, Hu, DL, Huang, RC, Huen, K, Jarvelin, MR, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Kupers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melen, E, Melton, P, Murphy, SK, Nawrot, TS, Nistico, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sorensen, TIA, Starling, AP, Sunyer, J, Ataylor, J, Tiemeier, Henning, Ullemar, V, Vafeiadi, M, van IJzendoorn, Marinus, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, CJ, Xu, ZL, Yang, IV, Yousefi, P, Zhang, HM, Zhang, WM, Zhao, SS, Agha, G, Relton, CL, Jaddoe, Vincent, and London, SJ

Published
2018

99. Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Author

Beaumont, RN, Warrington, NM, Cavadino, A, Tyrrell, J, Nodzenski, M, Horikoshi, M, Geller, F, Myhre, R, Richmond, Rebecca, Paternoster, L, Bradfield, JP, Kreiner-Moller, E, Huikari, V, Metrustry, S, Lunetta, KL, Painter, JN, Hottenga, JJ, Allard, C, Barton, SJ, Espinosa, A, Marsh, JA, Potter, C, Zhang, G, Ang, W, Berry, DJ, Bouchard, L, Das, S, Hakonarson, H, Heikkinen, J, Helgeland, O, Hocher, B, Hofman, Bert, Inskip, HM, Jones, SE, Kogevinas, M, Lind, PA, Marullo, L, Medland, SE, Murray, A, Murray, JC, Njolstad, PR, Nohr, EA, Reichetzeder, C, Ring, SM, Ruth, KS, Santa-Marina, L, Scholtens, DM, Sebert, S, Sengpiel, V, Tuke, MA, Vaudel, M, Weedon, MN, Willemsen, G, Wood, AR, Yaghootkar, H, Muglia, LJ, Bartels, M, Relton, CL, Pennell, CE, Chatzi, L, Estivill, X, Holloway, JW, Boomsma, DI, Montgomery, GW, Murabito, JM, Spector, TD, Power, C, Jarvelin, MR, Bisgaard, H, Grant, SFA, Sorensen, TIA, Jaddoe, Vincent, Jacobsson, B, Melbye, M, McCarthy, MI, Hattersley, AT, Hayes, MG, Frayling, TM, Hivert, MF, Felix, Janine, Hypponen, E, Lowe, WL, Evans, DM, Lawlor, DA, Feenstra, B, Freathy, RM, Beaumont, RN, Warrington, NM, Cavadino, A, Tyrrell, J, Nodzenski, M, Horikoshi, M, Geller, F, Myhre, R, Richmond, Rebecca, Paternoster, L, Bradfield, JP, Kreiner-Moller, E, Huikari, V, Metrustry, S, Lunetta, KL, Painter, JN, Hottenga, JJ, Allard, C, Barton, SJ, Espinosa, A, Marsh, JA, Potter, C, Zhang, G, Ang, W, Berry, DJ, Bouchard, L, Das, S, Hakonarson, H, Heikkinen, J, Helgeland, O, Hocher, B, Hofman, Bert, Inskip, HM, Jones, SE, Kogevinas, M, Lind, PA, Marullo, L, Medland, SE, Murray, A, Murray, JC, Njolstad, PR, Nohr, EA, Reichetzeder, C, Ring, SM, Ruth, KS, Santa-Marina, L, Scholtens, DM, Sebert, S, Sengpiel, V, Tuke, MA, Vaudel, M, Weedon, MN, Willemsen, G, Wood, AR, Yaghootkar, H, Muglia, LJ, Bartels, M, Relton, CL, Pennell, CE, Chatzi, L, Estivill, X, Holloway, JW, Boomsma, DI, Montgomery, GW, Murabito, JM, Spector, TD, Power, C, Jarvelin, MR, Bisgaard, H, Grant, SFA, Sorensen, TIA, Jaddoe, Vincent, Jacobsson, B, Melbye, M, McCarthy, MI, Hattersley, AT, Hayes, MG, Frayling, TM, Hivert, MF, Felix, Janine, Hypponen, E, Lowe, WL, Evans, DM, Lawlor, DA, Feenstra, B, and Freathy, RM

Published
2018

100. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5) (vol 6, 29, 2016)

Author

Bousquet, Jean, Farrell, J., Crooks, George, Hellings, P. W., Bel, E. H., Bewick, M., Chavannes, Niels H., Sousa, J. Correia de, Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, Anna, Aberer, W., Adachi, M., Agusti, A., Akdis, C. A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A. K., Barbara, Cristina, Bateman, E. D., Beghé, B., Kheder, A. Ben, Bennoor, K. S., Benson, M., Bergmann, K. C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. W., Camuzat, Thierry, Carlsen, K. H., Carr, W., Carriazo, A. M., Casale, T. B., Sarabia, A. C., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cirule, I., Cox, L., Costa, David J., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Blay, F. De, Dedeu, Antoni, Deleanu, D., Keenoy, E. De Manuel, Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Douagui, H. B., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fabbri, Leonardo M., Fletcher, M., Fiocchi, A., Wagner, A. Fink, Fonseca, J. A., Fokkens, W. J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, Judith, Gemicioǧlu, B., Gereda, J. E., Diaz, S. Gonzalez, Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Heaney, L. G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J. O. B., Howarth, P. H., Humbert, M., Hyland, M. E., Illario, M., Ivancevich, J. C., Jardim, J. R., Jares, E. J., Jeandel, Claude, Jenkins, C., Johnston, S. L., Jonquet, Olivier, Julge, K., Jung, K. S., Just, J., Kaidashev, I. P., Khaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, Tuyen D., Lieberman, P., Lipworth, B. J., Li, J., Carlsen, K. Lodrup, Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M. J., Manning, P. J., Mara, S., Marshall, G. D., Masjedi, M. R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Menzies-Gow, A., Merk, H., Michel, J. P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G. M. Y., Molimard, M., Momas, I., Montilla-Santana, A., Almeida, M. Morais, Morgan, M., Mosges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R. N., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H. S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Postma, D. S., Price, D., Rabe, K. F., Raciborski, F., Pontal, F. Radier, Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Manas, L. Rodriguez, Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G. K., Schunemann, H. J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, K. M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Sunyer, Jordi, Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Valia, E., Valovirta, E., Ganse, E. Van, Hage, M. van, Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D. Y., Wahn, U., Wickman, M., Williams, D. M., Williams, S., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, Jacques, Ear, Nose and Throat, Pulmonology, Yiallouros, Panayiotis K. [0000-0002-8339-9285], and Custovic, Adnan [0000-0001-5218-7071]

Abstract

[This corrects the article DOI: 10.1186/s13601-016-0116-9.]

Published
2017

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