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51. Traxler's collection of fragrant peonies /

Author

Fairyland Gardens, Traxler, Chas. J., Henry G. Gilbert Nursery and Seed Trade Catalog Collection, U.S. Department of Agriculture, National Agricultural Library, Fairyland Gardens, Traxler, Chas. J., and Henry G. Gilbert Nursery and Seed Trade Catalog Collection

Subjects
Catalogs, Flowers, Minneapolis, Minnesota, Nursery stock, Peonies, Seeds, Varieties
Published
1923

52. Price list of Traxler's collection of fragrant peonies from Fairyland Gardens /

Author

John A. Traxler (Firm), Traxler, Chas. J., Fairyland Gardens, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, U.S. Department of Agriculture, National Agricultural Library, John A. Traxler (Firm), Traxler, Chas. J., Fairyland Gardens, and Henry G. Gilbert Nursery and Seed Trade Catalog Collection

Subjects
Catalogs, Minneapolis, Minnesota, Nurseries (Horticulture), Nursery stock, Peonies, Prices
Published
1922

53. The giant oak and Fairyland /

Author

Traxler, Chas. J., Fairyland Gardens, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, John A. Traxler (Firm), U.S. Department of Agriculture, National Agricultural Library, Traxler, Chas. J., Fairyland Gardens, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, and John A. Traxler (Firm)

Subjects
Minneapolis, Minnesota, Nurseries (Horticulture), Oak, Peonies, Poetry
Published
1922

54. Catalogue of native and foreign grape vines at the Grape Vine Nursery /

Author

Grape Vine Nursery, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, Uhlmann, Chas. J., U.S. Department of Agriculture, National Agricultural Library, Grape Vine Nursery, Henry G. Gilbert Nursery and Seed Trade Catalog Collection, and Uhlmann, Chas. J.

Subjects
Catalogs, Grapes, Nurseries (Horticulture), Varieties
Published
1861

62. Patient-reported symptoms during direct-acting antiviral treatment: A real-life study in HIV-HCV coinfected patients (ANRS CO13 HEPAVIH)

Author

Marcellin, Fabienne, primary, Di Beo, Vincent, additional, Aumaitre, Hugues, additional, Mora, Marion, additional, Wittkop, Linda, additional, Duvivier, Claudine, additional, Protopopescu, Camelia, additional, Lacombe, Karine, additional, Esterle, Laure, additional, Berenger, Cyril, additional, Gilbert, Camille, additional, Bouchaud, Olivier, additional, Poizot-Martin, Isabelle, additional, Sogni, Philippe, additional, Salmon-Ceron, Dominique, additional, Carrieri, Patrizia, additional, Salmon, D., additional, Wittkop, L., additional, Sogni, P., additional, Esterle, L., additional, Trimoulet, P., additional, Izopet, J., additional, Serfaty, L., additional, Paradis, V., additional, Spire, B., additional, Carrieri, P., additional, Valantin, M.A., additional, Pialoux, G., additional, Chas, J., additional, Poizot-Martin, I., additional, Barange, K., additional, Naqvi, A., additional, Rosenthal, E., additional, Bicart-See, A., additional, Bouchaud, O., additional, Gervais, A., additional, Lascoux-Combe, C., additional, Goujard, C., additional, Lacombe, K., additional, Duvivier, C., additional, Neau, D., additional, Morlat, P., additional, Bani-Sadr, F., additional, Meyer, L., additional, Boufassa, F., additional, Autran, B., additional, Roque, A.M., additional, Solas, C., additional, Fontaine, H., additional, Costagliola, D., additional, Piroth, L., additional, Simon, A., additional, Zucman, D., additional, Boué, F., additional, Miailhes, P., additional, Billaud, E., additional, Aumaître, H., additional, Rey, D., additional, Peytavin, G., additional, Petrov-Sanchez, V., additional, Lebrasseur-Longuet, D., additional, Usubillaga, R., additional, Terris, B., additional, Tremeaux, P., additional, Katlama, C., additional, Stitou, H., additional, Cacoub, P., additional, Nafissa, S., additional, Benhamou, Y., additional, Charlotte, F., additional, Fourati, S., additional, Zaegel, O., additional, Laroche, H., additional, Tamalet, C., additional, Callard, P., additional, Bendjaballah, F., additional, Amiel, C., additional, Le Pendeven, C., additional, Marchou, B., additional, Alric, L., additional, Metivier, S., additional, Selves, J., additional, Larroquette, F., additional, Rio, V., additional, Haudebourg, J., additional, Saint-Paul, M.C., additional, De Monte, A., additional, Giordanengo, V., additional, Partouche, C., additional, Martin, A., additional, Ziol, M., additional, Baazia, Y., additional, Iwaka-Bande, V., additional, Gerber, A., additional, Uzan, M., additional, Garipuy, D., additional, Ferro-Collados, M.J., additional, Nicot, F., additional, Yazdanpanah, Y., additional, Adle-Biassette, H., additional, Alexandre, G., additional, Molina, J.M., additional, Bertheau, P., additional, Chaix, M.L., additional, Delaugerre, C., additional, Maylin, S., additional, Bottero, J., additional, Krause, J., additional, Girard, P.M., additional, Wendum, D., additional, Cervera, P., additional, Adam, J., additional, Viala, C., additional, Vittecocq, D., additional, Quertainmont, Y., additional, Teicher, E., additional, Pallier, C., additional, Lortholary, O., additional, Rouzaud, C., additional, Lourenco, J., additional, Touam, F., additional, Louisin, C., additional, Avettand-Fenoel, V., additional, Gardiennet, E., additional, Mélard, A., additional, Ochoa, A., additional, Blanchard, E., additional, Castet-Lafarie, S., additional, Cazanave, C., additional, Malvy, D., additional, Dupon, M., additional, Dutronc, H., additional, Dauchy, F., additional, Lacaze-Buzy, L., additional, Desclaux, A., additional, Bioulac-Sage, P., additional, Reigadas, S., additional, Lacoste, D., additional, Bonnet, F., additional, Bernard, N., additional, Hessamfar, J, M., additional, Paccalin, F., additional, Martell, C., additional, Pertusa, M.C., additional, Vandenhende, M., additional, Mercié, P., additional, Pistone, T., additional, Receveur, M.C., additional, Méchain, M., additional, Duau, P., additional, Rivoisy, C., additional, Faure, I., additional, Caldato, S., additional, Bellecave, P., additional, Tumiotto, C., additional, Pellegrin, J.L., additional, Viallard, J.F., additional, Lazzaro, E., additional, Greib, C., additional, Majerholc, C., additional, Brollo, M., additional, Farfour, E., additional, Polo Devoto, J., additional, Kansau, I., additional, Chambrin, V., additional, Pignon, C., additional, Berroukeche, L., additional, Fior, R., additional, Martinez, V., additional, Abgrall, S., additional, Favier, M., additional, Deback, C., additional, Lévy, Y., additional, Dominguez, S., additional, Lelièvre, J.D., additional, Lascaux, A.S., additional, Melica, G., additional, Raffi, F., additional, Allavena, C., additional, Reliquet, V., additional, Boutoille, D., additional, Biron, C., additional, Lefebvre, M., additional, Hall, N., additional, Bouchez, S., additional, Rodallec, A., additional, Le Guen, L., additional, Hemon, C., additional, Peyramond, D., additional, Chidiac, C., additional, Ader, F., additional, Biron, F., additional, Boibieux, A., additional, Cotte, L., additional, Ferry, T., additional, Perpoint, T., additional, Koffi, J., additional, Zoulim, F., additional, Bailly, F., additional, Lack, P., additional, Maynard, M., additional, Radenne, S., additional, Amiri, M., additional, Valour, F., additional, Augustin-Normand, C., additional, Scholtes, C., additional, Le-Thi, T.T., additional, Chavanet, P., additional, Duong Van Huyen, M., additional, Buisson, M., additional, Waldner-Combernoux, A., additional, Mahy, S., additional, Binois, R., additional, Simonet-Lann, A.L., additional, Croisier-Bertin, D., additional, Salmon Rousseau, A., additional, Martins, C., additional, Galim, S., additional, Lambert, D., additional, Nguyen, Y., additional, Berger, J.L., additional, Hentzien, M., additional, Brodard, V., additional, Partisani, M., additional, Batard, M.L., additional, Cheneau, C., additional, Priester, M., additional, Bernard-Henry, C., additional, de Mautort, E., additional, Gantner et S Fafi-Kremer, P., additional, Roustant, F., additional, Platterier, P., additional, Kmiec, I., additional, Traore, L., additional, Lepuil, S., additional, Parlier, S., additional, Sicart-Payssan, V., additional, Bedel, E., additional, Anriamiandrisoa, S., additional, Pomes, C., additional, Mole, M., additional, Bolliot, C., additional, Catalan, P., additional, Mebarki, M., additional, Adda-Lievin, A., additional, Thilbaut, P., additional, Ousidhoum, Y., additional, Makhoukhi, F.Z., additional, Braik, O., additional, Bayoud, R., additional, Gatey, C., additional, Pietri, M.P., additional, Le Baut, V., additional, Ben Rayana, R., additional, Bornarel, D., additional, Chesnel, C., additional, Beniken, D., additional, Pauchard, M., additional, Akel, S., additional, Lions, C., additional, Ivanova, A., additional, Ritleg, A.-S., additional, Debreux, C., additional, Chalal, L., additional, Zelie, J., additional, Hue, H., additional, Soria, A., additional, Cavellec, M., additional, Breau, S., additional, Joulie, A., additional, Fisher, P., additional, Gohier, S., additional, Ogoudjobi, S., additional, Brochier, C., additional, Thoirain-Galvan, V., additional, Le Cam, M., additional, Chalouni, M., additional, Conte, V., additional, Dequae-Merchadou, L., additional, Desvallees, M., additional, Gilbert, C., additional, Gillet, S., additional, Knight, R., additional, Lemboub, T., additional, Marcellin, F., additional, Michel, L., additional, Mora, M., additional, Protopopescu, C., additional, Roux, P., additional, Tezkratt, S., additional, Barré, T., additional, Baudoin, M., additional, Santos, M., additional, Di Beo, V., additional, and Nishimwe, M., additional

Published
2020
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63. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study

Author

Rodger, A. J., Cambiano, V., Phillips, A. N., Bruun, T., Raben, D., Lundgren, J., Vernazza, P., Collins, S., Degen, O., Corbelli, G. M., Estrada, V., Geretti, A. M., Beloukas, A., Coll, P., Antinori, A., Nwokolo, N., Rieger, A., Prins, J. M., Blaxhult, A., Weber, R., Van Eeden, A., Brockmeyer, N. H., Clarke, A., del Romero Guerrero, J., Raffi, F., Bogner, J. R., Wandeler, G., Gerstoft, J., Gutierrez, F., Brinkman, K., Kitchen, M., Ostergaard, L., Leon, A., Ristola, M., Jessen, H., Stellbrink, H. -J., Cobarsi, P., Nieto, A., Meulbroek, M., Carrillo, A., Saz, J., Guerrero, J. D. R., Garcia, M. V., Masia, M., Robledano, C., Leal, L., Redondo, E. G., Estrada, V. P., Marquez, R., Sandoval, R., Viciana, P., Espinosa, N., Lopez-Cortes, L., Podzamczer, D., Tiraboschi, J., Morenilla, S., Antela, A., Losada, E., Sewell, J., Kirk, S., Knott, A., Fernandez, T., Gompels, M., Jennings, L., Ward, L., Fox, J., Lwanga, J., Lee, M., Gilson, R., Leen, C., Morris, S., Clutterbuck, D., Brady, M., Asboe, D., Fedele, S., Fidler, S., Brockmeyer, N., Potthoff, A., Skaletz-Rorowski, A., Bogner, J., Seybold, U., Roider, J., Jessen, A., Ruzicic, S., Kummerle, T., Lehmann, C., Bartel, S., Hufner, A., Rockstroh, J., Mohrmann, K., Boesecke, C., Krznaric, I., Ingiliz, P., Grube, C., Braun, D., Gunthard, H., Furrer, H., Rauch, A., Schmid, P., Rasi, M., Borso, D., Stratmann, M., Caviezel, O., Stoeckle, M., Battegay, M., Tarr, P., Christinet, V., Jouinot, F., Isambert, C., Bernasconi, E., Bernasconi, B., Jensen, L. P., Bayer, A. A., Yehdego, Y., Bach, A., Handberg, P., Kronborg, G., Pedersen, S. S., Bulow, N., Ramskover, B., Debnam, O., Sutinen, J., Ask, R., Hildingsson-Lundh, B., Westling, K., Frisen, E. -M., Cortney, G., O'Dea, S., De Wit, S., Necsoi, C., Vandekerckhove, L., Goffard, J. -C., Henrard, S., Prins, J., Nobel, H. -H., Weijsenfeld, A., Elsenburg, L., Vos, D., Hoijenga, I., Gisolf, E., Van Bentum, P., Verhagen, D., Billaud, E., Ohayon, M., Gosset, D., Fior, A., Pialoux, G., Thibaut, P., Chas, J., Leclercq, V., Pechenot, V., Coquelin, V., Pradier, C., Breaud, S., Touzeau-Romer, V., Kitchen - Maria Geit, M., Sarcletti, M., Gisinger, M., Oellinger, A., Menichetti, S., Bini, T., Mussini, C., Meschiari, M., Di Biagio, A., Taramasso, L., Celesia, B. M., Gussio, M., Janeiro, N., AII - Infectious diseases, Infectious diseases, Imperial College Healthcare NHS Trust- BRC Funding, Department of Medicine, University Management, Clinicum, and HUS Inflammation Center

Subjects
Male, SERODISCORDANT COUPLES, HIV Infections, 030204 cardiovascular system & hematology, Condoms, Sexual and Gender Minorities, 0302 clinical medicine, Unsafe Sex, Antiretroviral Therapy, Highly Active, Epidemiology, INFECTION, HIV Seropositivity, Medicine and Health Sciences, 030212 general & internal medicine, Homosexuality, Prospective Studies, Prospective cohort study, 610 Medicine & health, 11 Medical and Health Sciences, media_common, Transmission (medicine), virus diseases, General Medicine, Middle Aged, Viral Load, Sexual Partners, PARTNER Study Group, Viral load, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Anti-HIV Agents, media_common.quotation_subject, education, Antiretroviral Therapy, Article, 03 medical and health sciences, Medicine, General & Internal, General & Internal Medicine, medicine, Humans, Highly Active, Seroconversion, SEMEN, Homosexuality, Male, Science & Technology, business.industry, HIV Seropositivity/transmission, HIV, PREVENTION, 3121 General medicine, internal medicine and other clinical medicine, Anti-HIV Agents/therapeutic use, BLOOD-PLASMA, RNA, Observational study, HETEROSEXUAL TRANSMISSION, business, Demography
Abstract

BACKGROUND: The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared with the evidence available for transmission risk in heterosexual couples. The aim of the second phase of the PARTNER study (PARTNER2) was to provide precise estimates of transmission risk in gay serodifferent partnerships.METHODS: The PARTNER study was a prospective observational study done at 75 sites in 14 European countries. The first phase of the study (PARTNER1; Sept 15, 2010, to May 31, 2014) recruited and followed up both heterosexual and gay serodifferent couples (HIV-positive partner taking suppressive ART) who reported condomless sex, whereas the PARTNER2 extension (to April 30, 2018) recruited and followed up gay couples only. At study visits, data collection included sexual behaviour questionnaires, HIV testing (HIV-negative partner), and HIV-1 viral load testing (HIV-positive partner). If a seroconversion occurred in the HIV-negative partner, anonymised phylogenetic analysis was done to compare HIV-1 pol and env sequences in both partners to identify linked transmissions. Couple-years of follow-up were eligible for inclusion if condomless sex was reported, use of pre-exposure prophylaxis or post-exposure prophylaxis was not reported by the HIV-negative partner, and the HIV-positive partner was virally suppressed (plasma HIV-1 RNA FINDINGS: Between Sept 15, 2010, and July 31, 2017, 972 gay couples were enrolled, of which 782 provided 1593 eligible couple-years of follow-up with a median follow-up of 2·0 years (IQR 1·1-3·5). At baseline, median age for HIV-positive partners was 40 years (IQR 33-46) and couples reported condomless sex for a median of 1·0 years (IQR 0·4-2·9). During eligible couple-years of follow-up, couples reported condomless anal sex a total of 76 088 times. 288 (37%) of 777 HIV-negative men reported condomless sex with other partners. 15 new HIV infections occurred during eligible couple-years of follow-up, but none were phylogenetically linked within-couple transmissions, resulting in an HIV transmission rate of zero (upper 95% CI 0·23 per 100 couple-years of follow-up).INTERPRETATION: Our results provide a similar level of evidence on viral suppression and HIV transmission risk for gay men to that previously generated for heterosexual couples and suggest that the risk of HIV transmission in gay couples through condomless sex when HIV viral load is suppressed is effectively zero. Our findings support the message of the U=U (undetectable equals untransmittable) campaign, and the benefits of early testing and treatment for HIV.FUNDING: National Institute for Health Research.

Published
2019

64. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study

Author

Cambiano, V, Bruun, T, Collins, S, Corbelli, GM, Geretti, AM, Beloukas, A, Raben, D, Prins, JM, Van Eeden, A, Guerrero, JD, Bogner, JR, Phillips, AN, Lundgren, J, Viciana, P, Espinosa, N, Lopez-Cortes, L, Gutierrez, F, Masia, M, Robledano, C, Coll, P, Cobarsi, P, Nieto, A, Podzamczer, D, Tiraboschi, J, Morenilla, S, Meulbroek, M, Carrillo, A, Saz, J, Estrada, V, Marquez, R, Sandoval, R, Antela, A, Losada, E, Leon, A, Leal, L, Redondo, EG, Garcia, MV, Asboe, D, Fedele, S, Nwokolo, N, Gilson, R, Gompels, M, Jennings, L, Ward, L, Brady, M, Clarke, A, Kirk, S, Knott, A, Fox, J, Lwanga, J, Lee, M, Leen, C, Morris, S, Clutterbuck, D, Fidler, S, Rodger, AJ, Fernandez, T, Sewell, J, Degen, O, Bartel, S, Hufner, A, Kummerle, T, Lehmann, C, Bogner, J, Seybold, U, Roider, J, Brockmeyer, NH, Potthoff, A, Skaletz-Rorowski, A, Stellbrink, HJ, Jessen, H, Jessen, A, Ruzicic, S, Rockstroh, J, Mohrmann, K, Boesecke, C, Krznaric, I, Ingiliz, P, Prins, J, Nobel, HE, Weijsenfeld, A, Brinkman, K, Vos, D, Hoijenga, I, Verhagen, D, van Eeden, A, Elsenburg, L, Gisolf, E, van Bentum, P, Weber, R, Grube, C, Braun, D, Wandeler, G, Furrer, H, Rauch, A, Stoeckle, M, Tarr, P, Battegay, M, Vernazza, P, Schmid, P, Rasi, M, Bernasconi, E, Bernasconi, B, Christinet, V, Jouinot, F, Isambert, C, Borso, D, Stratmann, M, Caviezel, O, Bini, T, Antinori, A, Menichetti, S, Celesia, BM, Gussio, M, Mussini, C, Meschiari, M, Di Biagio, A, Taramasso, L, Rieger, A, Touzeau-Romer, V, Kitchen, M, Sarcletti, M, Gisinger, M, Oelinger, A, Geit, M, Gerstoft, J, Jensen, LP, Bayer, AA, Handberg, P, Kronborg, G, Ostergaard, L, Pedersen, SS, Bulow, N, Ramskover, B, Pradier, C, Breaud, S, Raffi, F, Billaud, E, Ohayon, M, Gosset, D, Fior, A, Pialoux, G, Thibaut, P, Chas, J, Leclercq, V, Pechenot, V, Coquelin, V, Westling, K, Frisen, EM, Blaxhult, A, Ask, R, Hildingsson-Lundh, B, Ristola, M, Debnam, O, Sutinen, J, De Wit, S, Necsoi, C, Vandekerckhove, L, Goffard, JC, Henrard, S, Janeiro, N, Cortney, G, and O'Dea, S

Abstract

Background The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared with the evidence available for transmission risk in heterosexual couples. The aim of the second phase of the PARTNER study (PARTNER2) was to provide precise estimates of transmission risk in gay serodifferent partnerships. Methods The PARTNER study was a prospective observational study done at 75 sites in 14 European countries. The first phase of the study (PARTNER1; Sept 15, 2010, to May 31, 2014) recruited and followed up both heterosexual and gay serodifferent couples (HIV-positive partner taking suppressive ART) who reported condomless sex, whereas the PARTNER2 extension (to April 30, 2018) recruited and followed up gay couples only. At study visits, data collection included sexual behaviour questionnaires, HIV testing (HIV-negative partner), and HIV-1 viral load testing (HIV-positive partner). If a seroconversion occurred in the HIV-negative partner, anonymised phylogenetic analysis was done to compare HIV-1 pol and env sequences in both partners to identify linked transmissions. Couple-years of follow-up were eligible for inclusion if condomless sex was reported, use of pre-exposure prophylaxis or post-exposure prophylaxis was not reported by the HIV-negative partner, and the HIV-positive partner was virally suppressed (plasma HIV-1 RNA < 200 copies per mL) at the most recent visit (within the past year). Incidence rate of HIV transmission was calculated as the number of phylogenetically linked HIV infections that occurred during eligible couple-years of follow-up divided by eligible couple-years of follow-up. Two-sided 95% CIs for the incidence rate of transmission were calculated using exact Poisson methods. Findings Between Sept 15, 2010, and July 31, 2017, 972 gay couples were enrolled, of which 782 provided 1593 eligible couple-years of follow-up with a median follow-up of 2.0 years (IQR 1.1-3.5). At baseline, median age for HIV-positive partners was 40 years (IQR 33-46) and couples reported condomless sex for a median of 1.0 years (IQR 0.4-2.9). During eligible couple-years of follow-up, couples reported condomless anal sex a total of 76 088 times. 288 (37%) of 777 HIV-negative men reported condomless sex with other partners. 15 new HIV infections occurred during eligible couple-years of follow-up, but none were phylogenetically linked within-couple transmissions, resulting in an HIV transmission rate of zero (upper 95% CI 0.23 per 100 couple-years of follow-up). Interpretation Our results provide a similar level of evidence on viral suppression and HIV transmission risk for gay men to that previously generated for heterosexual couples and suggest that the risk of HIV transmission in gay couples through condomless sex when HIV viral load is suppressed is effectively zero. Our findings support the message of the U=U (undetectable equals untransmittable) campaign, and the benefits of early testing and treatment for HIV. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.

Published
2019

65. Daily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus-co-infected patients (ANRS CO13-HEPAVIH)

Author

Dabis, F., Chas, J., Rey, D., Wittkop, L., Sogni, P., Carrieri, P., Grp, ANRS CO13 HEPAVIH Study, Nordmann, S., Vilotitch, A., Roux, P., Esterle, L., Spire, B., Marcellin, F., Salmon-Ceron, D., DUFOUR, Jean-Charles, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, [SDV]Life Sciences [q-bio], HIV Infections, Hepacivirus, medicine.disease_cause, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Prospective Studies, 030212 general & internal medicine, Ultrasonography, education.field_of_study, biology, Coinfection, Lamivudine, Middle Aged, Hepatitis C, 3. Good health, [SDV] Life Sciences [q-bio], Infectious Diseases, Liver, Cohort, Female, 030211 gastroenterology & hepatology, France, medicine.drug, Adult, medicine.medical_specialty, Hepatitis C virus, Population, Marijuana Smoking, 03 medical and health sciences, Virology, Internal medicine, medicine, Humans, education, Hepatology, business.industry, Odds ratio, medicine.disease, biology.organism_classification, Fatty Liver, Cross-Sectional Studies, Logistic Models, Cannabis, Insulin Resistance, Steatosis, business, Body mass index
Abstract

Summary Liver steatosis is common in human immunodeficiency virus (HIV)-hepatitis C virus (HCV)-co-infected patients. Some recent studies have found that cannabis use is negatively associated with insulin resistance in the general population and in HIV-HCV-co-infected patients. Given the causal link between insulin resistance and steatosis, we hypothesized that cannabis use has a positive impact on steatosis. Therefore, we aimed to study whether cannabis use in this population was associated with a reduced risk of steatosis, measured by ultrasound examination. ANRS CO13-HEPAVIH is a French nationwide multicentre cohort of HIV-HCV-co-infected patients. Medical and socio-behavioural data from clinical follow-up visits and annual self-administered questionnaires were prospectively collected. A cross-sectional analysis was conducted using data from the first visit where both ultrasound examination data for steatosis (positive or negative diagnosis) and data on cannabis use were available. A logistic regression model was used to evaluate the association between cannabis use and steatosis. Among study sample patients (n = 838), 40.1% had steatosis. Fourteen per cent reported daily cannabis use, 11.7% regular use and 74.7% no use or occasional use (“never or sometimes”). Daily cannabis use was independently associated with a reduced prevalence of steatosis (adjusted odds ratio [95% CI] = 0.64 [0.42;0.99]; P = .046), after adjusting for body mass index, hazardous alcohol consumption and current or lifetime use of lamivudine/zidovudine. Daily cannabis use may be a protective factor against steatosis in HIV-HCV-co-infected patients. These findings confirm the need for a clinical evaluation of cannabis-based pharmacotherapies in this population. Eudract.ema.europa.eu number, DGS050367.

Published
2018

70. Efficacy, safety and patient‐reported outcomes of ledipasvir/sofosbuvir in NS3/4A protease inhibitor‐experienced individuals with hepatitis C virus genotype 1 and HIV coinfection with and without cirrhosis (ANRS HC31 SOFTRIH study)

Author

Rosenthal, E, primary, Fougerou‐Leurent, C, additional, Renault, A, additional, Carrieri, MP, additional, Marcellin, F, additional, Garraffo, R, additional, Teicher, E, additional, Aumaitre, H, additional, Lacombe, K, additional, Bailly, F, additional, Billaud, E, additional, Chevaliez, S, additional, Dominguez, S, additional, Valantin, MA, additional, Reynes, J, additional, Naqvi, A, additional, Cotte, L, additional, Metivier, S, additional, Leroy, V, additional, Dupon, M, additional, Allegre, T, additional, De Truchis, P, additional, Jeantils, V, additional, Chas, J, additional, Salmon‐Ceron, D, additional, Morlat, P, additional, Neau, D, additional, Perré, P, additional, Piroth, L, additional, Pol, S, additional, Bourlière, M, additional, Pageaux, GP, additional, Alric, L, additional, Zucman, D, additional, Girard, PM, additional, Poizot‐Martin, I, additional, Yazdanpanah, Y, additional, Raffi, F, additional, Pabic, E Le, additional, Tual, C, additional, Pailhé, A, additional, Amri, I, additional, Bellissant, E, additional, and Molina, JM, additional

Published
2017
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75. The Midwives Bill

Author

Brierley, Jas. Brassey and Cullingworth, Chas. J.

Published
1896

77. Aseptic Midwifery

Author

Palm, Theobald A., Freeman, W. T., Aitken, C. Crawford, Newell, A. G., McLean, Chas. J. R., and MacIlwaine, S. W.

Published
1898

82. An Appeal

Author

Topping, J. Phillip, Stocker, Chas. J., Collier, R. J., Muthu, Chowry, and Shimeld, J.

Published
1891

91. General Medical Council Election

Author

Cox, Alfred, Kirby, E. D., Neal, James, Thomas, F. G., Hanson, A., Fothergill, E. Rowland, Martin, Chas. J., Hunter, J. H., Fuller, J. R., Paterson, D. R., Treasure, W. B. Crawford, Thomson, J. Tatham, Wallace, Thos., Stevens, W. Mitchell, Fiddian, Alex. P., Sheen, William, Maclean, Ewen J., Thomas, R. Russell, Renshaw, Charles J., Buckley, Samuel, Renshaw, C. Adolphe R., Renshaw, J. A. Knowles, Cooper, P. R., and Broadbent, G. H.

Published
1906

99. Clayden V. Wood-Hill

Author

Jones, Robert, Gask, George E., Elmslie, R. C., Lynn-Thomas, John, Ballance, Hamilton A., Tyson, Wilson, Girling, Chas J., Curties, A. W. S., and Welsh, Robt. A.

Published
1921

100. Insurance Correspondence

Author

Douglas, C. E., Beetham, Herbert A., Lowman, W. H., Stratford, Howard M., Aitken, Chas. J. Hill, and Day, J. J.

Published
1923

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