Search

Zn(CF3SO3)2 as an electrolyte has been widely used to improve the electrochemical performance for ZIBs due to that the bulky CF3SO3− can reduce the solvation effect of Zn2+ and promote the ionic diffusion. Herein, we found that Zn(CF3SO3)2 electrolyte can induce different electrochemical mechanisms from ZnSO4 electrolyte. Compared to the ZnSO4 electrolyte, the HNaV6O16·4H2O electrode with Zn(CF3SO3)2 electrolyte exhibits a high capacity of 444 mAh·g−1 at 500 mA·g−1 with a capacity retention of 92.3% after 80 cycles. Even, at a high rate of 5 A·g−1, the HNaV6O16·4H2O electrode delivers an initial discharge capacity of 328 mAh·g−1 with a capacity retention of 93.7% after 1000 cycles. Differing from the mechanism with ZnSO4 electrolyte, the excellent cycle stability of HNaV6O16·4H2O electrode can be attributed to the in-situ phase transformation to ZnxV2O5·nH2O based on the co-intercalation of Zn2+/H+.

AIM: To study the diagnostic value of gene rearrangement detection combined with vitreous fluid interleukin-10(IL-10)and interleukin-6(IL-6)cytokine detection for primary intraocular lymphoma(PIOL). METHODS: A total of 27 patients with suspected PIOL who were admitted to the hospital between January 2015 and December 2019 were enrolled in this study according to the inclusion and exclusion criteria. Totally 21 cases of PIOL and 6 cases of uveitis were diagnosed by pathological examination of diagnostic vitrectomy. Results of gene rearrangement and cytokine levels were retrospectively analyzed. Receiver operating characteristic(ROC)curves were used to analyze the diagnostic value of gene rearrangement, cytokines detection and the combination of the two in PIOL. RESULTS: Of the 21 patients with PIOL, 15 had IhH FR2 monoclonal rearrangement, with a positive rate of 71%(15/21), and 4 were detected with TCRG clonal gene rearrangement. ROC curve analysis showed that the area under the curve(AUC)of gene rearrangement for diagnosis of PIOL was 0.857. Its sensitivity and specificity were 71.43% and 100.00%. Patients with PIOL had significantly higher vitreous humor IL-10 and IL-10/IL-6 levels than those with uveitis, but no statistically significant difference was found in the IL-6 level between the two groups(P>0.05). ROC curve analysis showed that the AUC of IL-10 was the highest for diagnosis of PIOL. With 170.90pg/mL as the cut-off value, its sensitivity and specificity of IL-10 in diagnosing PIOL were 66.67% and 100.00%, respectively. With 1.95 as the cut-off value, the sensitivity and specificity of IL-10/IL-6 ratio in diagnosing PIOL were 52.40% and 100.00%. The AUC, sensitivity and specificity of gene rearrangement combined with cytokines detection in diagnosing PIOL were 0.893, 95.24% and 83.33%, respectively. CONCLUSION: The sensitivity of gene rearrangement alone is poor in diagnosing PIOL. Combined use of cytokines detection can improve the diagnostic sensitivity and specificity.

This is the first study to explore the positive effects of ginseng stem and leaf saponins (GSLS) on antioxidant capability, immunity, and disease resistance of crucian carp. Seven hundred fifty crucian carps (initial body weight: 25 ± 0.15 g (mean ± SE)) were randomly allocated into five groups with three replicates each; five diets supplemented with the final concentration of 0, 1, 2, 4, and 8 g/kg GSLS were fed to crucian carp for 5 weeks. The results demonstrated that, at a concentration of 8 g/kg, the contents of IgM, C4, SOD, GSH-Px, and the activity of AKP in serum of crucian carp gradually increased at 7, 14, 21, 28, and 35 days, and the expression of immune-relative cytokine genes (TNF-α, IL-10, IFN-γ) in the liver, spleen, and the intestinal tract also had a significant up-regulation (P 0.05), and which were significant difference compared with control (P 0.05). The above results demonstrated that dietary GSLS showed enhancement effects on the antioxidant and anti-inflammatory capability, and innate immune response of crucian carp. The feed of 8 g/kg GSLS for 1 week could improve the survival rate 44% more than the control group when crucian carp infected Aeromonas hydrophila (A. hydrophila). In conclusion, the addition of GSLS at a concentration of 8 g/kg in the diet improve immune-related enzyme activity better, immune-relative cytokine expression, and disease resistance.

An effective method for disassembling large-sized waste products is to utilise two-sided disassembly lines. A mixed-integer programming model for two-sided disassembly lines is constructed in this ...

In the context of an automated assembly line and flexible manufacturing, good layout planning of the production facilities aids in improving production efficiency and reducing production costs. The current research on the facility layout problems mainly focuses on the static ones with the fixed flow between facilities, including the parallel row ordering problem (PROP). Based on existing research on the PROP, in this study, we first investigate the dynamic parallel row ordering problem (DPROP), considering the flexibility of the production line. This study proposes a DPROP model and utilises it to verify some PROP examples less than 15 facilities and some global optimal solutions are achieved. In addition, the performance of the model in solving DPROP is verified on some new small-scale examples designed based on the PROP. Owing to the limited performance of the exact methods for DPROP, this study proposes a hybrid algorithm of harmony search and tabu search to solve large-scale problems, and this new algorithm performs better than some existing ones so that some new better solutions for the PROP examples are obtained. The algorithm is first utilised to solve the small-scale PROP and DPROP and the results are compared with an exact methods. Moreover, by evaluating the large-scale PROP between 30 and 70 facilities, the results are compared with those of the improved genetic algorithm and the population-based simulated annealing algorithm, thereby 28.8 % of the current optimal solutions are improved. Finally, the hybrid algorithm of harmony search and tabu search is utilised to solve the large-scale DPROP with 30 and 40 facilities, and some optimal solution sequences are presented.

Introduction Laryngeal squamous cell carcinoma (LSCC) is the most common histological subtype of laryngeal cancer. The involved molecular mechanisms and suitable therapeutic targets for LSCC still need to be further investigated. Checkpoint kinase 2 (CHK2) participates in several cellular physiology pathways and plays a role in tumor progression. However, the roles of CHK2 in LSCC remain unclear. Methods mRNA expression data were obtained from The Cancer Genome Atlas (TCGA) database, and bioinformatic analysis was performed. Western blot and immunohistochemical analyses were conducted to detect protein expression. MTS assays were performed to examine cell growth of LSCC-derived cell lines. Results In the present study, we found that both active form of CHK2 and total CHK2 protein expressions were up-regulated in LSCC tissues. Positive expression of CHK2 was closely associated with advanced clinical features and poor prognosis. Moreover, potential CHK2-involving bioprocesses and signaling pathways were analyzed. In addition, repressed proliferation of LSCC cells was induced by CHK2 inhibitor. Discussion Taken together, our findings elucidated that CHK2 may act as an oncogenic factor in LSCC, suggesting a potential target for clinical treatment.

To reduce waste during disassembly production and improve disassembly efficiency, this study investigates a type of partial parallel disassembly line applicable for the simultaneous disassembly of different products. A multi-objective mathematical model for a partial parallel disassembly line balancing problem is built considering four optimisation goals, namely, the minimisation of the cycle time, number of workstations, idle index, and quantity of disassembly resources. In addition, a novel multi-objective hybrid group neighbourhood search algorithm is proposed. First, a certain set of neighbourhood individuals (from the current population of individuals) is generated via neighbourhood search mechanisms based on optimal embedding and exchange operations. Then, a Pareto filtering process is performed on a mixed population composed of the individuals of the current population and all neighbourhoods. Subsequently, the current population individuals are renewed based on the mixed population. To prevent the algorithm from falling into a local optimum and to enhance the algorithm’s global search performance, we conduct a local search strategy based on a simulated annealing operation on the newly generated population individuals. The effectiveness and superiority of the proposed algorithm are proven by solving two complete disassembly line balancing problems at different scales and a partial disassembly line balancing problem, and also by comparison with several algorithms investigated in existing literature. Finally, the proposed model and algorithm are applied to a partial parallel disassembly line designed for the simultaneous disassembly of two types of waste products in a household appliance disassembly enterprise. The results of the partial parallel disassembly line are compared with those of an initial single-product straight disassembly line, and the comparison results show that the solution results of the optimisation goals for the partial parallel disassembly line are more superior than those of the initial single-product straight disassembly line.

Although micro RNA (miRNA) expression profiles are widely investigated in renal cell carcinoma (RCC), their potential roles for affecting RCC initiation and progression remain largely unknown. Here, we examined the aberrant expression profiles of miRNAs inhuman metastatic RCC tissues based on Gene Expression Omnibus (GSE37989). We further validated them iRNAs expression data in the largest clinical dataset: The Cancer Genome Atlas (TCGA). And cell adhesion and migration abilities and epithelial me senchymal transition (EMT) related proteins were assessed in both normal and tumor RCC cell lines. We suggest that hsa‐miR‐143 is a potential tumor suppressor in RCC as its down regulation positively correlated with adverse prognosis. Biologically, cell adhesion, migration, and EMT were dramatically inhibited by miR‐143. Mechanistically, we found that miR‐143 targets ABL proto‐oncogene 2 (ABL2), which was also found to be an indicator for poor survival in TCGA database. Our results have important implications in understanding functions of miRNAs in metastatic RCC and will provide a basis for further clinical application.

The single-row facility layout problem (SRFLP) decides upon the arrangement of facilities in a straight row so as to minimise the material handling cost. Generally, this problem allows the placemen...

The accurate diagnosis of small cell lung cancer (SCLC) at initial presentation is essential to ensure appropriate treatment. No validated blood biomarkers that could distinguish SCLC from non-small cell lung cancer (NSCLC) has yet been developed. Dried blood spot (DBS) microsampling has gained increasing interest in biomarkers discovery. In this study, we first performed metabolomic profiling of DBS samples from 37 SCLC, 40 NSCLC, and 37 controls. Two gender-specific multianalyte discriminant models were established for males and females, respectively to distinguish SCLC from NSCLC and controls. The receiver operator characteristic (ROC) curve analysis showed the diagnostic accuracy of 95% (95% CI: 83%-100%) in males SCLC using five metabolites in DBS and 94% (95% CI: 74%-100%) for females using another set of five metabolites. The robustness of the models was confirmed by the random permutation tests (P < 0.01 for both). The performance of the discriminant models was further evaluated using a validation cohort with 78 subjects. The developed discriminant models yielded an accuracy of 91% and 81% for males and females, respectively, in the validation cohort. Our results highlighted the potential clinical utility of the metabolomic profiling of DBS as a convenient and effective approach for the diagnosis of SCLC.

Reversible aqueous zinc-ion batteries (ZIBs) have great potential for large-scale energy storage owing to their low cost and safety. However, the lack of long-lifetime positive materials severely restricts the development of ZIBs. Herein, we report NaV6O15 microflowers as a cathode material for ZIBs with excellent electrochemical performance, including a high specific capacity of ∼300 mA h g−1 at 100 mA g−1 and 141 mA h g−1 maintained after 2000 cycles at 5 A g−1 with a capacity retention of ∼107%. The high diffusion coefficient and stable tunneled structure of NaV6O15 facilitate Zn2+ intercalation/extraction and long-term cycle stability.

The study of multiphase flow consisting of liquid and air bubbles has been attracting the interest of many researchers. Numerical methods for such a system are, however, facing difficulty in numerical accuracy and a heavy computational load. In this paper, we made corrections to the modified force-coupling method in our previous papers and applied it to the numerical studies of a single air bubble rising near a vertical wall and two interacting air bubbles rising in line in quiescent liquid. Corrections were made to the effective ranges of the force-coupling method. The calculation results showed that the lift force acting on an air bubble obtained by the experimental data was more accurately reproduced than those by our previous method. We accurately calculated the time evolution of the velocities of interacting two air bubbles rising in line obtained in the previous experiments and resolved the physical mechanism of the relative movement of two bubbles. We also found the present method is much quicker and needs much smaller memory capacity than other methods, such as the volume of fluid method.

The development of high capacity, low cost, and high safety cathode materials for rechargeable aqueous zinc-ion batteries (ZIBs) is an ongoing challenge. Herein, CuV2O6 nanowires are prepared by a facile hydrothermal method to be used as a high-capacity cathode material for ZIBs. The sample displays an initial discharge capacity of 338 mA h g-1 at a current density of 100 mA g-1 and a capacity of 143 mA h g-1 remained at 5 A g-1 after 1200 cycles with a retention of ∼100% except for the initial capacity decay. Systematic structural and elemental characterization confirms that the reduction/oxidation of Cu2+/Cu0 is reversible during the electrochemical process. This work provides new prospects for designing more cathode materials based on the displacement reaction mechanism for Zn-ion batteries.

Virtual assistants have become an essential part in many people’s lives today. These dialogue systems perform services given users’ voice commands, such as controlling devices, searching for information, or performing conversational tasks such as booking of events or navigation instruction. However, today’s dialogue systems face challenges, because (1) they are implemented using a pipeline of multiple independently optimized modules which do not necessarily provide the best performance when integrated together and (2) they are limited to utilizing only unimodal input, i.e. speech input from the user. The modularized system design induces a disconnect between each module’s and the quality of the overall dialogue system, and it also makes it difficult to update the entire system for a new task as every module will need to be changed. While the multimodal context contains rich information of the users and their surrounding environments, many dialogue systems in today’s virtual assistants interact with the users utilizing only their language input via a speech interface. As dialogue systems only utilize speech input, they are unable to provide services which require understanding the user or environmental context, for example conversing with a user regarding their physical surroundings. In this thesis, we mitigate the limitations of prior dialogue systems in two ways: (1) we propose an end-to-end model which fuses the separate components in a standard spoken dialogue system together and (2) we leverage multimoal contextual cues from the user andphysical surroundings. We introduce end-to-end learning for scalable dialogue state tracking, where the model directly predicts dialogue states from natural language input and can handle unseen slot values. We enhance our speech recognition system using multimodal input with the target speaker’s mouth movements and learned speaker embedding to improve robustness in noisy cocktail party environments. Finally, we apply end-to-end and multimodal learning on two situated dialogue tasks: vision-grounded instruction following and video question answering. The situated dialogue model directly takes as input the multimodal language and visual context from the user and the environment, and outputs system actions or natural language responses. Compared to prior methods, our proposed situated dialogue systems showed improved speech recognition accuracy, dialog state tracking accuracy, task success rate and response generation quality.

There has been growing interest in water-processable conjugated polymers for biocompatible devices. However, some broadly used conjugated polymers like poly(3-hexylthiophene) (P3HT) are hydrophobic and they cannot be processed in water. We herein report a facile yet highly efficient assembly method to prepare water-dispersible pyridine-containing P3HT (Py-P3HT) nanoparticles (NPs) with a high yield (80%) and a fine size below 100 nm. It is based on the fast nanoprecipitation of Py-P3HT stabilized by hydrophilic poly(acrylic acid) (PAA). Py-P3HT can form spherical NPs at a concentration up to 0.2 mg/mL with a diameter of

A new positioning algorithm based on RSS measurement is proposed. The algorithm adopts maximum likelihood estimation and semi-definite programming. The received signal strength model is transformed to a non-convex estimator for the positioning of the target using the maximum likelihood estimation. The non-convex estimator is then transformed into a convex estimator by semi-definite programming, and the global minimum of the target location estimation is obtained. This algorithm aims at the L0 known problem and then extends its application to the case of L0 unknown. The simulations and experimental results show that the proposed algorithm has better accuracy than the existing positioning algorithms.

Objectives: The risk factors for prostate cancer to progress to castration-resistant prostate cancer after androgen deprivation treatment (ADT) are still not to be well defined. We conducted this investigation in an attempt to determine factors that predicted the prognosis in a series of patients with prostate cancer after ADT. Methods: We retrospectively analyzed the database of patients treated with androgen deprivation prostate cancer who were hospitalized in the Second Affiliated Hospital of Bengbu Medical College and Maoming People's Hospital from 2015.1.1 to 2020.12.30. PSA dynamic changes, including nadir PSA (nPSA), time to nadir PSA (TTN), were examined regularly. Cox risk proportional regression model was used for univariate and multivariate analysis; Kaplan-Meier survival curve and Log-rank test were used to compare and analyze differences in biochemical progression-free survival (bPFS) between groups. Results: During the follow-up with a median time of 43.5 months, a total of 163 men were included in the study. The median bPFS of the two groups with nPSA lower than 0.2ng/ml and ≥0.2ng/ml were 27.6 months and 13.5, respectively, with significant differences between the groups (Log-rank pConclusions: PSA dynamic changes after androgen deprivation treatment of prostate cancer can be used as prognostic indicators for bPFS. The lower the nadir PSA value and the longer the time to nadir, the longer the bPFS of patients with prostatic cancer after androgen deprivation treatment.

High-pressure H2 was produced by the selective dehydrogenation of formic acid (DFA) using ruthenium complexes at mild temperatures in various organic solvents and water. Among the solvents studied, 1,4-dioxane was the best candidate for this reaction to generate high gas pressure of 20 MPa at 80 °C using the Ru complex having a dearomatized pyridine-based pincer PN3P* ligand. This complex shows reusability for the high-pressure DFA in 1,4-dioxiane while maintaining the catalytic performance, however, deactivation occurred in other solvents. In dimethyl sulfoxide, its decomposition products may cause catalytic deactivation. The gas pressure generated in 1,4-dioxane was lower than that in water due to the high dissolution of 1,4-dioxane into CO2 according the vapor-liquid equilibrium calculations. The role of solvent is crucial since it affected the catalytic performance and also the generated gas pressure (H2 and CO2) from FA.

Formic acid possesses many desirable properties as a promising hydrogen energy carrier. Density functional theory (DFT) was utilized to design new Rh complexes with 2,2′-biimidazoline ligands to explore their potential as catalysts for formic acid dehydrogenation. These designed complexes were prepared and examined as catalysts under various temperatures and ratios of formic acid to sodium formate. It was found that although our complexes gave a high TOF of 20,000 h−1 at 90 °C under certain formic acid/sodium formate ratios, the dehydrogenation reaction was prematurely deactivated once 30% of the formic acid was consumed. Possible deactivation mechanisms were investigated by NMR and HRMS. Our observations suggest that while guided rational design of catalysts by DFT has much potential, the method does have limitations as evidenced by our experimental comparisons and thus pure DFT design should be conducted with caution.

The novel multi-workshop facility layout problem presented in this paper involves the placement of a group of departments into several workshops; it deals with the distribution of departments over workshops and their optimal exact coordinates without overlapping. In considering practical situations, the internal material handling flows and external transport flows are taken into account in the problem. In this study, the problem is first formulated as a mixed integer linear programming model with three objectives: minimization of overall material handling costs, minimization of number of workshops, and maximization of utilization ratio of workshop floor. Thereafter, the proposed multi-objective particle swarm optimization algorithm with an innovative discrete framework and incorporated with a two-stage approach is employed to search for feasible solutions locally and globally. Finally, several benchmark instances derived from literature that satisfy our case requirements are employed to evaluate the performance of the proposed method; highly preferable results are typically achieved.

Despite the important role of biological soil crusts in the soil carbon cycles of desert ecosystems, the responses of soil respiration in biological soil crust-dominated areas to warming are not well understood. The goal of this study was to investigate the expected increases in temperature on soil respiration both diurnally and seasonally in biological soil crust-dominated areas. We used open-top chambers to simulate warming in the Shapotou region in the Tengger Desert, northern China. An automated soil respiration system was used to measure the soil respiration rates in moss-dominated crusts. The measured environmental variables included the precipitation, volumetric soil water content, air temperature and soil temperature at depths of 0, 5, 10, 20, and 50 cm. The response of soil respiration to warming is a function of soil moisture following rainfall in desert ecosystems. Our results showed that 1.5 °C of simulated warming significantly decreased soil respiration, indicating that the inhibition of soil respiration was likely due to the reduction in soil water content at a relatively high temperature. Over daily cycles, hourly soil respiration rates have commonly been related to hourly temperatures. The observed diel hysteresis between hourly soil respiration and temperature resulted in semielliptical hysteresis loops, and the temperature often lagged behind soil respiration for several hours. The lag times between soil respiration and temperature were significantly and positively related to the depth of the soil temperature measurements. The proximate reason for the diel hysteresis between soil respiration and temperature was likely a mismatch between the depth of CO2 production and the depth of the temperature measurements. Our results indicate that warming increases the response of soil respiration to soil water availability in biological soil crust-dominated desert ecosystems. Therefore, the accelerated drying effect of warming on soil respiration and diel soil respiration patterns between soil respiration and temperature at different depths should be considered in future soil carbon cycle models for biological soil crust-dominated desert ecosystems.

A BiVO4/TiO2 nanotube composite film was fabricated by anodization and low temperature solvothermal reaction for photocathodic protection. The results showed that after modifying the TiO2 nanotube film with BiVO4 nanoparticles, the light absorption of the BiVO4/TiO2 composite film was extended to the visible region. The photocurrent density of the composite film reached 271 μA cm−2, and was 8.5 times higher than that of the TiO2 film. Under white light irradiation, the composite film made the potential of the coupled 403 stainless steel in a 0.5 M NaCl solution drop by 520 mV, showing an effective photocathodic protection effect.

In order to obtain a TiO2 composite film with improved photoelectrochemical properties, a TiO2 nanotube array (NTA) film was constructed on a Ti substrate via anodization, then Ag nanoparticles (NPs) and carbon quantum dots (CQDs) were successively deposited on the TiO2 NTA film by pulse current deposition and hydrothermal treatment, respectively. After the sensitization by CQDs and Ag NPs, the light absorption of the TiO2 composite film was extended to the visible region. Under white light irradiation, the photocurrent density of the composite film in a 0.5 M Na2SO4 solution reached 110 μA cm−2, much higher than that (60 μA cm−2) of the single TiO2 film. The CQDs/Ag/TiO2 composite film as a photoanode showed an improved photocathodic protection effect, which made the potential of the coupled 403 stainless steel (403SS) in the 0.5 M NaCl solution drop by 400 mV relative to its corrosion potential.

In the existing literature on the corridor allocation problem (CAP), the corridor width is not taken into consideration. But in the actual production, the corridor width plays a very important role in logistics transportation inside factories. To study the effect of the corridor width in a CAP problem, the corridor width is considered by a mixed-integer programming model proposed in this paper. Subsequently, an improved scatter search (ISS) algorithm is proposed to handle the CAP. Several improvement mechanisms have been applied to the ISS according to the special characteristics of the problem, such as the adoption of a simulated annealing operation, a dynamic reference set update method, and an improved subset generation method. The proposed ISS is evaluated on test instances of various sizes ranging from 9 to 49 facilities. Computational results demonstrate the validity of the ISS. Specifically, for small-sized instances, the acquired best solutions by the ISS are identical to the optimal solutions obtained by the exact solution given by GUROBI, while for moderate and large-sized instances, the objective values by the ISS are better than those solved by the method in GUROBI. Furthermore, the proposed algorithm shows better performance in solution quality and stability by comparing to the simulated annealing algorithm and the scatter search algorithm.

Objective To evaluate the safety and long-term results of 131I therapy without antithyroid drug (ATD) pretreatment for patients with severe hyperthyroidism (SH). Methods Clinical data of 637 patients with SH, admitted in the Department of Nuclear Medicine, the former 307th Hospital of Chinese PLA from Jan. 1975 to Dec. 2014, treated with 131I without ATD pretreatment and followed up for more than one year, were recruited in present study. SPSS 20.0 software was used to analyze the therapeutic efficacy, serum levels of thyroid hormone (TH) and thyroid therapeutic activity, etc. Results Based on the clinical characteristics, the 637 patients were divided into seven groups: severe thyroid dysfunction, thyrotoxic heart disease, complicated with severe liver dysfunction, complicated with large goiter, complicated with huge goiter, complicated with severe cytopenia, and complicated with thyrotoxic periodic paralysis, etc. Five hundred and Forty cases (84.8%) were cured, 53 cases (8.3%) with complete remission, and 44 cases (6.9%) with incomplete remission. Hypothyroidism was noted in 363 cases (57.0%). No significant clinical worsening was found in 637 patients after 131I therapy. The thyroid hormones (TH) level returned to normal within 12 months after 131I therapy in 510 patients (80.1%). The efficacy of 131I therapy was closely correlated to the administered activity of 131I. The dose of 131I therapy was 2.59 to 11.11MBq per gram of thyroid with an average of (3.82±0.80)MBq, and the total 131I activity administrated for the individuals was 85.1-3496.5MBq with an average of (447.7±407.0)MBq. The cure rate after one dose of 131I therapy was 81.8%. The serum TH level was decreased significantly in patients with severe jaundice by lithium carbonate prescribed shortly before and after 131I therapy. The 131I therapy instead of surgical treatment is safe and effective for those patients complicated with huge goiter and heart disease and unsuitable for surgery. 131I therapy does not affect fertility, and there have been 57 patients who have given birth of 59 healthy babies. Conclusion 131I therapy without ATD pretreatment is safe and effective for patients with SH. Based on comprehensive treatment, the individualized 131I therapy for such patients should be considered as early as possible. DOI: 10.11855/j.issn.0577-7402.2019.02.09

A PN3P pincer ligand (1) bearing dicyclopentylphosphine substituents reacts with [Rh(COD)Cl]2 (COD = 1,5-cyclooctadiene) to produce the complex (PN3P)RhCl (2). Treatment of a benzene solution of 2 with KN(SiMe3)2 stimulates a dearomatization process, and C–H activation of benzene is achieved through the rearomatization of the central pyridine ring. This deprotonation/reprotonation of the NH arm of 2 gives the phenyl complex (PN3P)Rh(C6H5) (3). The subsequent introduction of CO gas into 3 yields the benzoyl complex (PN3P)RhCO (C6H5) (4), which can release benzaldehyde upon treatment with diluted HCl solution and regenerates 2.

PN3P-Ir pincer hydride complexes were synthesized and characterized as catalysts and key intermediates in the direct hydrogenation of CO2 to formate under mild conditions. The formation of a dearomatized PN3P*-Ir(i)-CO species was identified as a plausible key process accountable for the loss of catalytic activity in the CO2 hydrogenation.

The production of 1-butene by ethylene dimerization is an important chemical industrial process currently implemented using homogeneous catalysts. Here, we describe a highly active heterogeneous catalyst (Ni-ZIF-8) for ethylene dimerization, which consists of isolating Ni-active sites selectively located on the crystal surface of a zeolitic imidazolate framework. Ni-ZIF-8 can be easily prepared by a simple one-pot synthesis method in which site-specific anchoring of Ni is achieved spontaneously because of the incompatibility between the d8 electronic configuration of Ni2+ and the three-dimensional framework of ZIF-8. The full exposure and square-planar coordination of the Ni sites accounts for the high catalytic activity of Ni-ZIF-8. It exhibits an average ethylene turnover frequency greater than 1 000 000 h-1 (1-butene selectivity >85%) at 35 °C and 50 bar, far exceeding the activities of previously reported heterogeneous catalysts and many homogeneous catalysts under similar conditions. Moreover, compared to molecular Ni complexes used as homogeneous catalysts for ethylene dimerization, Ni-ZIF-8 has significantly higher stability and shows constant activity during 4 h of continuous reaction. Isotopic labeling experiments indicate that ethylene dimerization over Ni-ZIF-8 follows the Cossee-Arlman mechanism, and detailed characterizations combined with density functional theory calculations rationalize this observed high activity.

BackgroundRenal cell carcinoma (RCC) is a fatal malignant tumor with high morbidity. Numerous medical studies have suggested that long noncoding RNAs (lncRNAs) exert their biological function on various cancerous progresses. Herein, functions of lncRNA SNHG16 in RCC cells and the mechanism medicated by SNHG16 were investigated.MethodsThe expression levels of SNHG16 and its downstream genes in RCC cells and tissues were examined utilizing reverse transcription quantitative polymerase chain reaction analyses. Cell counting kit-8 and 5-Ethynyl-2’-deoxyuridine assays were carried out to evaluate the proliferation of RCC cells, and flow cytometry analyses were employed to determine the apoptosis of RCC cells. Western blot analysis was applied to examine protein levels associated with cell proliferation and apoptosis. The combination between SNHG16 and miRNA as well as miRNA and its target gene were explored by luciferase reporter, RNA pull down, and RNA immunoprecipitation assays.ResultsThe significant upregulation of SNHG16 was observed in RCC tissues and cells. SNHG16 downregulation inhibited the proliferation and promoted the apoptosis of RCC cells. In addition, SNHG16 served as a competing endogenous RNA for miR-1301-3p, and STARD9 was a target gene of miR-1301-3p in RCC cells. SNHG16 upregulated STARD9 expression by binding with miR-1301-3p in RCC cells. Rescue assays validated that SNHG16 promoted RCC cell promotion and induced RCC cell apoptosis by upregulating STARD9 expression.ConclusionsSNHG16 promotes RCC cell proliferation and suppresses RCC cell apoptosis via interaction with miR-1301-3p to upregulate STARD9 expression in RCC cells.

The double-row layout problem (DRLP) is a well-known optimization problem that generally deals with the arrangement of machines or other such entities on the two sides along a corridor. Based on the placement of the machinery and equipment in a factory, this study analyzes the DRLP from a new perspective that addresses the arrangement of the given machines subject to the condition that certain designated positions are allocated to certain machines and specific relationships are enforced among the machines. This DRLP is termed as a constrained DRLP (cDRLP). In this study, considering the practical applications, four variations of the cDRLP have been developed for the first time and solved. Additionally, to solve this problem, some constraints (positioning, ordering, and relation constraints) have been defined and classified. Furthermore, mathematical models have been built with the objective of minimizing the total material handling cost. Next, the CPLEX software has been adopted to solve the above variations. Finally, a series of numerical instances have been employed to evaluate the efficiency of the proposed models and obtain the exact results.

Space deployable antennna has the characteristics of Lightweight, large diameter, high precision etc, which can meet the requirements of the launch vehicle carrying and payload’s Electromagnetic performance. Antenna’s mesh dividing have the direct bearing on payload’s Electromagnetic performance, geodesic mesh dividing has the advantage of shortest length of mseh line. but the equation solving of geodesic is complicated,which Impeding the geodesic’s application In academic and engineering fields. in this paper, a method has be proposed to solve the difficulty of geodesic equation solving. the solving result can be used in antenna’s mesh dividing, meanwhile the solving result can be used in Robot trajectory planning, Air route planning,Navigation route planning,Architectural structure design,etc. great care should be taken in constructing both.

Renal cell carcinoma (RCC) is the leading cancer affecting humans; however, the relationship between tumour-infiltrating lymphocytes (TILs) and patient prognosis in RCC is relatively unreported. This study aimed to investigate the relationships among factors (TIL, clinicopathological characteristics, and patient prognosis in RCC). This retrospective study evaluated 533 patients with clear cell renal cell carcinoma (ccRCC) deposited in the the Cancer Genome Atlas between 2004 and 2015. We downloaded immune cell type absolute fraction data for ccRCC patients from the Cancer Immunome Atlas database. The CIBERSORT method was used to transform RNA-sequencing data into microarray data for the cancer genome atlas -ccRCC samples for which microarray and RNA-sequencing data were available on the the Cancer Immunome Atlas website. The overall survival (OS) and disease free survival (DFS) analyses of ccRCC patients showed that M1 macrophages (OS, P = .00000134; DFS, P = .00958) and neutrophils (OS, P = .00000723; DFS, P = .0255) were significant. Age at diagnosis (P

To investigate the role of previous cancer on overall survival in patients with bladder cancer (BCa) and to establish an effective prognostic tool for individualized overall survival prediction. A total of 78,660 patients diagnosed with BCa between 2000 and 2013 were selected from the Surveillance, Epidemiology, and End Results (SEER) database, among which 8915 patients had a history of other cancers. We compared the overall survival between patients with and without previous cancer after propensity score matching and we further established a nomogram for overall survival prediction. Univariate and multivariate Cox analyses were used to determine independent prognostic factors. The calibration curve and concordance index (C-index) were used to assess the accuracy of the nomogram. Cox proportional hazards models and Kaplan–Meier analysis were used to compare survival outcomes. BCa patients with previous cancer had worse overall survival compared with those without previous cancer (HR = 1.37; 95%CI = 1.32–1.42, P

Growing evidence points at an association between microRNAs and tumor development. Although dysregulation of microRNA-103a-3p (miR-103a-3p) in multiple human cancers has been reported, its expression in prostate cancer (PCa) remains unknown and there is currently no research on the relationship between miR-103a-3p and tumor protein D52 (TPD52) in PCa. Our aim in this study was to explore the effect and potential mechanism of miR-103a-3p in PCa. qRT-PCR was performed to detected the level of miR-103a-3p in PCa tissues and cells, and in normal tissues. Colony, wound-healing, invasion, proliferation, and apoptosis assays were performed in search miR-103a-3p effect in PCa. TargetScan was used to predict potential targets of miR-103a-3p. Additionally, dual-luciferase reporter, western blot, and immunofluorescence assays were performed to detected the target gene of miR-103a-3p. Finally, we explore the differences in tumor xenograft experiments between nude mice injected with stably miR-103a-3p expressing cells and those expressing a miR-negative control. Low level of miR-103a-3p was detected in PCa tissues and cells, when compared with normal tissues. Enhancement of miR-103a-3p significantly inhibited migration and invasion of PCa cells, and negatively regulated expression of the oncogenic tumor protein D52 (TPD52) through direct binding to its 3'-UTR. Interestingly, overexpression of TPD52 significantly attenuated the effect of mir-103a-3p on PCa. Our study provides the first evidence that miR-103a-3p directly targets TPD52 and inhibits the proliferation and invasion of PCa. This finding helps clarify the role of mir-103a-3p-TPD52 axis in PCa and may provide new therapeutic targets for the disease.

Reversible aqueous zinc-ion batteries (ZIBs) have great potential for large-scale energy storage owing to their low cost and safety. However, the lack of long-lifetime positive materials severely restricts the development of ZIBs. Herein, we report NaV

Introduction Laryngeal squamous cell carcinoma (LSCC) is the most common histological subtype of laryngeal cancer. The involved molecular mechanisms and suitable therapeutic targets for LSCC still need to be further investigated. Checkpoint kinase 2 (CHK2) participates in several cellular physiology pathways and plays a role in tumor progression. However, the roles of CHK2 in LSCC remain unclear. Methods mRNA expression data were obtained from The Cancer Genome Atlas (TCGA) database, and bioinformatic analysis was performed. Western blot and immunohistochemical analyses were conducted to detect protein expression. MTS assays were performed to examine cell growth of LSCC-derived cell lines. Results In the present study, we found that both active form of CHK2 and total CHK2 protein expressions were up-regulated in LSCC tissues. Positive expression of CHK2 was closely associated with advanced clinical features and poor prognosis. Moreover, potential CHK2-involving bioprocesses and signaling pathways were analyzed. In addition, repressed proliferation of LSCC cells was induced by CHK2 inhibitor. Discussion Taken together, our findings elucidated that CHK2 may act as an oncogenic factor in LSCC, suggesting a potential target for clinical treatment.

Soil respiration is an important ecosystem process in drylands and is closely related to soil temperature but often occurs out of phase with soil temperature. As ecosystem engineers in dryland ecosystems, biological soil crusts (biocrusts) greatly affect soil carbon cycle processes, such as soil respiration. However, the diel hysteresis pattern between soil respiration and soil temperature at biocrusted microsites and its influencing factors are not well understood. Here, we performed continuous field measurements of in situ soil respiration to evaluate the effect of biocrusts on the diurnal cycles of soil respiration and the influencing factors of the diel hysteresis pattern between soil respiration and soil temperature at biocrusted microsites. Over daily cycles, soil respiration peaked earlier than soil temperature, and their relationship exhibited similar clockwise hysteresis loops at both bare and biocrusted microsites. Unexpectedly, the effect of biocrusts on the diel hysteresis pattern between soil respiration and soil temperature was negligible. However, photosynthesis may be the key driver regulating the diel hysteresis pattern between soil respiration and soil temperature, because little or even no hysteresis was observed between soil respiration and photosynthetically active radiation. Our results highlight the important role of photosynthate transportation in plants or biocrusts in diel hysteresis pattern regulation between soil respiration and soil temperature.