11,093 results on '"Chan Y"'
Search Results
52. Charge Trapping and Energy Performance of the MAJORANA DEMONSTRATOR
- Author
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bhimani, K. H., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lannen V, T. E., Li, A., López-Castaño, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Oli, T. K., Othman, G., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Schaper, D. C., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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Physics - Instrumentation and Detectors - Abstract
P-type point contact (PPC) high-purity germanium detectors are an important technology in astroparticle and nuclear physics due to their superb energy resolution, low noise, and pulse shape discrimination capabilities. Analysis of data from the MAJORANA DEMONSTRATOR, a neutrinoless double-beta decay experiment deploying PPC detectors enriched in $^{76}$Ge, has led to several novel improvements in the analysis of PPC signals. In this work we discuss charge trapping in PPC detectors and its effect on energy resolution. Small dislocations or impurities in the crystal lattice result in trapping of charge carriers from an ionization event of interest, attenuating the signal and degrading the measured energy. We present a modified digital pole-zero correction to the signal energy estimation that counters the effects of charge trapping and improves the energy resolution of the MAJORANA DEMONSTRATOR by approximately 30% to around 2.4 keV FWHM at 2039 keV, the $^{76}$Ge $Q$-value. An alternative approach achieving similar resolution enhancement is also presented., Comment: 12 pages, 13 figures
- Published
- 2022
- Full Text
- View/download PDF
53. Interpretable Boosted Decision Tree Analysis for the Majorana Demonstrator
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bhimani, K. H., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y -D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Elliott, S. R., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lannen V, T. E., Li, A., Lopez-Castano, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Oli, T. K., Othman, G., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Schaper, D. C., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., and Yu, C. -H.
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Physics - Data Analysis, Statistics and Probability ,Computer Science - Machine Learning ,Nuclear Experiment - Abstract
The Majorana Demonstrator is a leading experiment searching for neutrinoless double-beta decay with high purity germanium detectors (HPGe). Machine learning provides a new way to maximize the amount of information provided by these detectors, but the data-driven nature makes it less interpretable compared to traditional analysis. An interpretability study reveals the machine's decision-making logic, allowing us to learn from the machine to feedback to the traditional analysis. In this work, we have presented the first machine learning analysis of the data from the Majorana Demonstrator; this is also the first interpretable machine learning analysis of any germanium detector experiment. Two gradient boosted decision tree models are trained to learn from the data, and a game-theory-based model interpretability study is conducted to understand the origin of the classification power. By learning from data, this analysis recognizes the correlations among reconstruction parameters to further enhance the background rejection performance. By learning from the machine, this analysis reveals the importance of new background categories to reciprocally benefit the standard Majorana analysis. This model is highly compatible with next-generation germanium detector experiments like LEGEND since it can be simultaneously trained on a large number of detectors., Comment: 13 pages, 9 figures
- Published
- 2022
- Full Text
- View/download PDF
54. Final Result of the MAJORANA DEMONSTRATOR's Search for Neutrinoless Double-$\beta$ Decay in $^{76}$Ge
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Barton, P. J., Bhimani, K. H., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lannen V, T. E., Li, A., Lopez, A. M., López-Castaño, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Oli, T. K., Othman, G., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Schaper, D. C., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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Nuclear Experiment ,High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
The MAJORANA DEMONSTRATOR searched for neutrinoless double-$\beta$ decay ($0\nu\beta\beta$) of $^{76}$Ge using modular arrays of high-purity Ge detectors operated in vacuum cryostats in a low-background shield. The arrays operated with up to 40.4 kg of detectors (27.2 kg enriched to $\sim$88\% in $^{76}$Ge). From these measurements, the DEMONSTRATOR has accumulated 64.5 kg yr of enriched active exposure. With a world-leading energy resolution of 2.52 keV FWHM at the 2039 keV $Q_{\beta\beta}$ (0.12\%), we set a half-life limit of $0\nu\beta\beta$ in $^{76}$Ge at $T_{1/2}>8.3\times10^{25}$ yr (90\% C.L.). This provides a range of upper limits on $m_{\beta\beta}$ of $(113-269)$ meV (90\% C.L.), depending on the choice of nuclear matrix elements., Comment: 8 pages, 2 figures
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- 2022
- Full Text
- View/download PDF
55. Exotic dark matter search with the Majorana Demonstrator
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bhimani, K. H., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lannen V, T. E., Li, A., Lopez, A. M., López-Castaño, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Oli, T. K., Othman, G., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Schaper, D. C., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
With excellent energy resolution and ultra-low level radiogenic backgrounds, the high-purity germanium detectors in the Majorana Demonstrator enable searches for several classes of exotic dark matter (DM) models. In this work, we report new experimental limits on keV-scale sterile neutrino DM via the transition magnetic moment from conversion to active neutrinos, $\nu_s \rightarrow \nu_a$. We report new limits on fermionic dark matter absorption ($\chi + A \rightarrow \nu + A$) and sub-GeV DM-nucleus 3$\rightarrow$2 scattering ($\chi + \chi + A \rightarrow \phi + A$), and new exclusion limits for bosonic dark matter (axionlike particles and dark photons). These searches utilize the (1--100)-keV low energy region of a 37.5-kg y exposure collected by the Demonstrator between May 2016 and November 2019, using a set of $^{76}$Ge-enriched detectors whose surface exposure time was carefully controlled, resulting in extremely low levels of cosmogenic activation., Comment: 7 pages, 6 figures
- Published
- 2022
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56. Search for solar axions via axion-photon coupling with the Majorana Demonstrator
- Author
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bhimani, K. H., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lannen V, T. E., Li, A., Lopez, A. M., López-Castaño, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Oli, T. K., Othman, G., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Schaper, D. C., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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Nuclear Experiment ,High Energy Physics - Experiment - Abstract
Axions were originally proposed to explain the strong-CP problem in QCD. Through the axion-photon coupling, the Sun could be a major source of axions, which could be measured in solid state detection experiments with enhancements due to coherent Primakoff-Bragg scattering. The Majorana Demonstrator experiment has searched for solar axions with a set of $^{76}$Ge-enriched high purity germanium detectors using a 33 kg-yr exposure collected between Jan. 2017 and Nov. 2019. A temporal-energy analysis gives a new limit on the axion-photon coupling as $g_{a\gamma}<1.45\times 10^{-9}$ GeV$^{-1}$ (95% C.I.) for axions with mass up to 100 eV/$c^2$. This improves laboratory-based limits between about 1 eV/$c^2$ and 100 eV/$c^2$., Comment: Minor updates to match published version
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- 2022
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57. Final Result of the Majorana Demonstrator’s Search for Neutrinoless Double-β Decay in Ge76
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Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Barton, PJ, Bhimani, KH, Blalock, E, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cuesta, C, Detwiler, JA, Efremenko, Yu, Ejiri, H, Elliott, SR, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Henning, R, Hervas Aguilar, D, Hoppe, EW, Hostiuc, A, Kidd, MF, Kim, I, Kouzes, RT, Lannen V, TE, Li, A, Lopez, AM, López-Castaño, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Mertens, S, Oli, TK, Othman, G, Paudel, LS, Pettus, W, Poon, AWP, Radford, DC, Reine, AL, Rielage, K, Ruof, NW, Schaper, DC, Tedeschi, D, Varner, RL, Vasilyev, S, Wilkerson, JF, Wiseman, C, Xu, W, Yu, C-H, and Zhu, BX
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Nuclear and Plasma Physics ,Particle and High Energy Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Majorana Collaboration ,Mathematical Sciences ,Engineering ,General Physics ,Mathematical sciences ,Physical sciences - Abstract
The Majorana Demonstrator searched for neutrinoless double-β decay (0νββ) of ^{76}Ge using modular arrays of high-purity Ge detectors operated in vacuum cryostats in a low-background shield. The arrays operated with up to 40.4 kg of detectors (27.2 kg enriched to ∼88% in ^{76}Ge). From these measurements, the Demonstrator has accumulated 64.5 kg yr of enriched active exposure. With a world-leading energy resolution of 2.52 keV FWHM at the 2039 keV Q_{ββ} (0.12%), we set a half-life limit of 0νββ in ^{76}Ge at T_{1/2}>8.3×10^{25} yr (90% C.L.). This provides a range of upper limits on m_{ββ} of (113-269) meV (90% C.L.), depending on the choice of nuclear matrix elements.
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- 2023
58. Interpretable boosted-decision-tree analysis for the Majorana Demonstrator
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Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Bhimani, KH, Blalock, E, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cuesta, C, Detwiler, JA, Efremenko, Yu, Elliott, SR, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Henning, R, Aguilar, D Hervas, Hoppe, EW, Hostiuc, A, Kidd, MF, Kim, I, Kouzes, RT, V., TE Lannen, Li, A, López-Castaño, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Oli, TK, Othman, G, Paudel, LS, Pettus, W, Poon, AWP, Radford, DC, Reine, AL, Rielage, K, Ruof, NW, Schaper, DC, Tedeschi, D, Varner, RL, Vasilyev, S, Wilkerson, JF, Wiseman, C, Xu, W, and Yu, C-H
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Nuclear and Plasma Physics ,Physical Sciences ,Nuclear and plasma physics - Abstract
The Majorana Demonstrator is a leading experiment searching for neutrinoless double-beta decay with high purity germanium (HPGe) detectors. Machine learning provides a new way to maximize the amount of information provided by these detectors, but the data-driven nature makes it less interpretable compared to traditional analysis. An interpretability study reveals the machine's decision-making logic, allowing us to learn from the machine to feed back to the traditional analysis. In this work, we present the first machine learning analysis of the data from the Majorana Demonstrator; this is also the first interpretable machine learning analysis of any germanium detector experiment. Two gradient boosted decision tree models are trained to learn from the data, and a game-theory-based model interpretability study is conducted to understand the origin of the classification power. By learning from data, this analysis recognizes the correlations among reconstruction parameters to further enhance the background rejection performance. By learning from the machine, this analysis reveals the importance of new background categories to reciprocally benefit the standard Majorana analysis. This model is highly compatible with next-generation germanium detector experiments like LEGEND since it can be simultaneously trained on a large number of detectors.
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- 2023
59. NTIRE 2022 Challenge on High Dynamic Range Imaging: Methods and Results
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Pérez-Pellitero, Eduardo, Catley-Chandar, Sibi, Shaw, Richard, Leonardis, Aleš, Timofte, Radu, Zhang, Zexin, Liu, Cen, Peng, Yunbo, Lin, Yue, Yu, Gaocheng, Zhang, Jin, Ma, Zhe, Wang, Hongbin, Chen, Xiangyu, Wang, Xintao, Wu, Haiwei, Liu, Lin, Dong, Chao, Zhou, Jiantao, Yan, Qingsen, Zhang, Song, Chen, Weiye, Liu, Yuhang, Zhang, Zhen, Zhang, Yanning, Shi, Javen Qinfeng, Gong, Dong, Zhu, Dan, Sun, Mengdi, Chen, Guannan, Hu, Yang, Li, Haowei, Zou, Baozhu, Liu, Zhen, Lin, Wenjie, Jiang, Ting, Jiang, Chengzhi, Li, Xinpeng, Han, Mingyan, Fan, Haoqiang, Sun, Jian, Liu, Shuaicheng, Marín-Vega, Juan, Sloth, Michael, Schneider-Kamp, Peter, Röttger, Richard, Li, Chunyang, Bao, Long, He, Gang, Xu, Ziyao, Xu, Li, Zhan, Gen, Sun, Ming, Wen, Xing, Li, Junlin, Li, Jinjing, Li, Chenghua, Gang, Ruipeng, Li, Fangya, Liu, Chenming, Feng, Shuang, Lei, Fei, Liu, Rui, Ruan, Junxiang, Dai, Tianhong, Li, Wei, Lu, Zhan, Liu, Hengyan, Huang, Peian, Ren, Guangyu, Luo, Yonglin, Liu, Chang, Tu, Qiang, Ma, Sai, Cao, Yizhen, Tel, Steven, Heyrman, Barthelemy, Ginhac, Dominique, Lee, Chul, Kim, Gahyeon, Park, Seonghyun, Vien, An Gia, Mai, Truong Thanh Nhat, Yoon, Howoon, Vo, Tu, Holston, Alexander, Zaheer, Sheir, and Park, Chan Y.
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Computer Science - Computer Vision and Pattern Recognition ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
This paper reviews the challenge on constrained high dynamic range (HDR) imaging that was part of the New Trends in Image Restoration and Enhancement (NTIRE) workshop, held in conjunction with CVPR 2022. This manuscript focuses on the competition set-up, datasets, the proposed methods and their results. The challenge aims at estimating an HDR image from multiple respective low dynamic range (LDR) observations, which might suffer from under- or over-exposed regions and different sources of noise. The challenge is composed of two tracks with an emphasis on fidelity and complexity constraints: In Track 1, participants are asked to optimize objective fidelity scores while imposing a low-complexity constraint (i.e. solutions can not exceed a given number of operations). In Track 2, participants are asked to minimize the complexity of their solutions while imposing a constraint on fidelity scores (i.e. solutions are required to obtain a higher fidelity score than the prescribed baseline). Both tracks use the same data and metrics: Fidelity is measured by means of PSNR with respect to a ground-truth HDR image (computed both directly and with a canonical tonemapping operation), while complexity metrics include the number of Multiply-Accumulate (MAC) operations and runtime (in seconds)., Comment: CVPR Workshops 2022. 15 pages, 21 figures, 2 tables
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- 2022
60. Experimental study of 13C({\alpha},n)16O reactions in the Majorana Demonstrator calibration data
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MAJORANA Collaboration, Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bhimani, K. H., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lannen V, T. E., Li, A., Lopez, A. M., Lopez-Castano, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Oli, T. K., Othman, G., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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Nuclear Experiment ,High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
Neutron captures and delayed decays of reaction products are common sources of backgrounds in ultra-rare event searches. In this work, we studied $^{13}$C($\alpha,n)^{16}$O reactions induced by $\alpha$-particles emitted within the calibration sources of the \textsc{Majorana Demonstrator}. These sources are thorium-based calibration standards enclosed in carbon-rich materials. The reaction rate was estimated by using the 6129-keV $\gamma$-rays emitted from the excited $^{16}$O states that are populated when the incoming $\alpha$-particles exceed the reaction Q-value. Thanks to the excellent energy performance of the \textsc{Demonstrator}'s germanium detectors, these characteristic photons can be clearly observed in the calibration data. Facilitated by \textsc{Geant4} simulations, a comparison between the observed 6129-keV photon rates and predictions by a TALYS-based software was performed. The measurements and predictions were found to be consistent, albeit with large statistical uncertainties. This agreement provides support for background projections from ($\alpha,n$)-reactions in future double-beta decay search efforts., Comment: Published version
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- 2022
- Full Text
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61. Search for charge nonconservation and Pauli exclusion principle violation with the Majorana Demonstrator
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MAJORANA Collaboration, Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bhimani, K. H., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lannen V, T. E., Li, A., Lopez, A. M., López-Castaño, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Oli, T. K., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Schaper, D. C., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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Nuclear Experiment ,High Energy Physics - Experiment - Abstract
Charge conservation and the Pauli exclusion principle (PEP) result from fundamental symmetries in the Standard Model, and are typically taken as axiomatic. High-precision tests for small violations of these symmetries could point to new physics. In this work we consider three models for violation of these processes which would produce detectable ionization in the high-purity germanium detectors of the Majorana Demonstrator. Using a 37.5 kg-yr exposure, we report a new lower limit on the electron mean lifetime of $\tau_e > 3.2 \times 10^{25}$ yr (90\% CL), the best result for this decay channel ($e \rightarrow \nu_e \overline{\nu_e} \nu_e$ or more generally $e \rightarrow \mathrm{invisibles}$) in more than two decades. We also present searches for two types of violation of the PEP, setting new limits on the probability of two electrons forming a symmetric quantum state. Using our $^{228}$Th calibration data set, which introduces electrons new to the system through electron-positron pair production, we obtain a world-leading model-independent limit for a terrestrial experiment of $\beta^2/2 < 1.0 \times 10^{-3}$ (99.7\% CL). Our 37.5 kg-yr exposure is also used to search for a process where an electron in an atomic system spontaneously violates the PEP, resulting in a model-dependent upper limit of $\beta^2/2 < 1.0 \times 10^{-48}$ (90\% CL).
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- 2022
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62. Fixed-duration pirtobrutinib plus venetoclax with or without rituximab in relapsed/refractory CLL: the phase 1b BRUIN trial
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Roeker, Lindsey E., Woyach, Jennifer A., Cheah, Chan Y., Coombs, Catherine C., Shah, Nirav N., Wierda, William G., Patel, Manish R., Lamanna, Nicole, Tsai, Donald E., Nair, Binoj, Wang, Chunxiao, Zhao, Xiang, Liu, Dan, Radtke, David, Chapman, Sonya, Marella, Narasimha, McNeely, Samuel C., and Brown, Jennifer R.
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- 2024
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63. Pirtobrutinib, a highly selective, non-covalent (reversible) BTK inhibitor in patients with B-cell malignancies: analysis of the Richter transformation subgroup from the multicentre, open-label, phase 1/2 BRUIN study
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Wierda, William G, Shah, Nirav N, Cheah, Chan Y, Lewis, David, Hoffmann, Marc S, Coombs, Catherine C, Lamanna, Nicole, Ma, Shuo, Jagadeesh, Deepa, Munir, Talha, Wang, Yucai, Eyre, Toby A, Rhodes, Joanna M, McKinney, Matthew, Lech-Maranda, Ewa, Tam, Constantine S, Jurczak, Wojciech, Izutsu, Koji, Alencar, Alvaro J, Patel, Manish R, Seymour, John F, Woyach, Jennifer A, Thompson, Philip A, Abada, Paolo B, Ho, Caleb, McNeely, Samuel C, Marella, Narasimha, Nguyen, Bastien, Wang, Chunxiao, Ruppert, Amy S, Nair, Binoj, Liu, Hui, Tsai, Donald E, Roeker, Lindsey E, and Ghia, Paolo
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- 2024
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64. Measurements of the Influence of Integral Length Scale on Stagnation Region Heat Transfer
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G. James Van Fossen and Chan Y. Ching
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Heat Transfer ,Stagnation Flow ,Turbulence ,Length Scale ,Leading Edge. ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The purpose of the present work was twofold: first, to determine if a length scale existed that would cause the greatest augmentation in stagnation region heat transfer for a given turbulence intensity and second, to develop a prediction tool for stagnation heat transfer in the presence of free stream turbulence. Toward this end, a model with a circular leading edge was fabricated with heat transfer gages in the stagnation region. The model was qualified in a low turbulence wind tunnel by comparing measurements with Frossling's solution for stagnation region heat transfer in a laminar free stream. Five turbulence generating grids were fabricated; four were square mesh, biplane grids made from square bars. Each had identical mesh to bar width ratio but different bar widths. The fifth grid was an array of fine parallel wires that were perpendicular to the axis of the cylindrical leading edge. Turbulence intensity and integral length scale were measured as a function of distance from the grids. Stagnation region heat transfer was measured at various distances downstream of each grid. Data were taken at cylinder Reynolds numbers ranging from 42,000 to 193,000. Turbulence intensities were in the range 1.1 to 15.9 percent while the ratio of integral length scale to cylinder diameter ranged from 0.05 to 0.30. Stagnation region heat transfer augmentation increased with decreasing length scale. An optimum scale was not found. A correlation was developed that fit heat transfer data for the square bar grids to within ±4%. The data from the array of wires were not predicted by the correlation; augmentation was higher for this case indicating that the degree of isotropy in the turbulent flow field has a large effect on stagnation heat transfer. The data of other researchers are also compared with the correlation.
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- 1997
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65. Search for Spontaneous Radiation from Wavefunction Collapse in the Majorana Demonstrator
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Efremenko, Yu., Ejiri, H., Elliott, S. R., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kim, I., Kouzes, R. T., Lannen V, T. E., Lopez, A. M., López-Castaño, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Oli, T. K., Othman, G., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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Nuclear Experiment ,High Energy Physics - Experiment - Abstract
The Majorana Demonstrator neutrinoless double-beta decay experiment comprises a 44 kg (30 kg enriched in $^{76}\mathrm{Ge}$) array of $p$-type, point-contact germanium detectors. With its unprecedented energy resolution and ultralow backgrounds, Majorana also searches for rare event signatures from beyond standard model physics in the low energy region below 100 keV. In this Letter, we test the continuous spontaneous localization (CSL) model, one of the mathematically well-motivated wave function collapse models aimed at solving the long-standing unresolved quantum mechanical measurement problem. While the CSL predicts the existence of a detectable radiation signature in the x-ray domain, we find no evidence of such radiation in the 19--100 keV range in a 37.5 kg-y enriched germanium exposure collected between December 31, 2015, and November 27, 2019, with the Demonstrator. We explored both the non-mass-proportional (n-m-p) and the mass-proportional (m-p) versions of the CSL with two different assumptions: that only the quasifree electrons can emit the x-ray radiation and that the nucleus can coherently emit an amplified radiation. In all cases, we set the most stringent upper limit to date for the white CSL model on the collapse rate, $\lambda$, providing a factor of 40--100 improvement in sensitivity over comparable searches. Our limit is the most stringent for large parts of the allowed parameter space. If the result is interpreted in terms of the Di\`osi-Penrose gravitational wave function collapse model, the lower bound with a 95% confidence level is almost an order of magnitude improvement over the previous best limit., Comment: This document was corrected in accordance with the erratum: https://doi.org/10.1103/PhysRevLett.130.239902. The number presented in the recent version of this article is correct
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- 2022
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- View/download PDF
66. Vector induced skewing of antibody Fc-effector functions
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Chung A, Dugast A, Robinson H, Chan Y, Ackerman ME, Cox J, Koff W, Barouch D, Rerks-Ngarm S, Michael N, Kim J, and Alter G
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Immunologic diseases. Allergy ,RC581-607 - Published
- 2012
- Full Text
- View/download PDF
67. Search for Spontaneous Radiation from Wave Function Collapse in the Majorana Demonstrator
- Author
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Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Bhimani, KH, Blalock, E, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cuesta, C, Detwiler, JA, Efremenko, Yu, Ejiri, H, Elliott, SR, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Henning, R, Hervas Aguilar, D, Hoppe, EW, Hostiuc, A, Kim, I, Kouzes, RT, Lannen V, TE, Li, A, Lopez, AM, López-Castaño, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Oli, TK, Othman, G, Paudel, LS, Pettus, W, Poon, AWP, Radford, DC, Reine, AL, Rielage, K, Ruof, NW, Tedeschi, D, Varner, RL, Vasilyev, S, Wilkerson, JF, Wiseman, C, Xu, W, Yu, C-H, and Zhu, BX
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Nuclear and Plasma Physics ,Particle and High Energy Physics ,Physical Sciences ,Majorana Collaboration ,Mathematical Sciences ,Engineering ,General Physics ,Mathematical sciences ,Physical sciences - Abstract
The Majorana Demonstrator neutrinoless double-beta decay experiment comprises a 44 kg (30 kg enriched in ^{76}Ge) array of p-type, point-contact germanium detectors. With its unprecedented energy resolution and ultralow backgrounds, Majorana also searches for rare event signatures from beyond standard model physics in the low energy region below 100 keV. In this Letter, we test the continuous spontaneous localization (CSL) model, one of the mathematically well-motivated wave function collapse models aimed at solving the long-standing unresolved quantum mechanical measurement problem. While the CSL predicts the existence of a detectable radiation signature in the x-ray domain, we find no evidence of such radiation in the 19-100 keV range in a 37.5 kg-y enriched germanium exposure collected between December 31, 2015, and November 27, 2019, with the Demonstrator. We explored both the non-mass-proportional (n-m-p) and the mass-proportional (m-p) versions of the CSL with two different assumptions: that only the quasifree electrons can emit the x-ray radiation and that the nucleus can coherently emit an amplified radiation. In all cases, we set the most stringent upper limit to date for the white CSL model on the collapse rate, λ, providing a factor of 40-100 improvement in sensitivity over comparable searches. Our limit is the most stringent for large parts of the allowed parameter space. If the result is interpreted in terms of the Diòsi-Penrose gravitational wave function collapse model, the lower bound with a 95% confidence level is almost an order of magnitude improvement over the previous best limit.
- Published
- 2022
68. Search for Solar Axions via Axion-Photon Coupling with the Majorana Demonstrator
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Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Bhimani, KH, Blalock, E, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cuesta, C, Detwiler, JA, Efremenko, Yu, Ejiri, H, Elliott, SR, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Henning, R, Hervas Aguilar, D, Hoppe, EW, Hostiuc, A, Kidd, MF, Kim, I, Kouzes, RT, Lannen V, TE, Li, A, Lopez, AM, López-Castaño, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Oli, TK, Othman, G, Paudel, LS, Pettus, W, Poon, AWP, Radford, DC, Reine, AL, Rielage, K, Ruof, NW, Schaper, DC, Tedeschi, D, Varner, RL, Vasilyev, S, Wilkerson, JF, Wiseman, C, Xu, W, Yu, C-H, and Zhu, BX
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Particle and High Energy Physics ,Physical Sciences ,Majorana Collaboration ,Mathematical Sciences ,Engineering ,General Physics ,Mathematical sciences ,Physical sciences - Abstract
Axions were originally proposed to explain the strong-CP problem in QCD. Through axion-photon coupling, the Sun could be a major source of axions, which could be measured in solid state detection experiments with enhancements due to coherent Primakoff-Bragg scattering. The Majorana Demonstrator experiment has searched for solar axions with a set of ^{76}Ge-enriched high purity germanium detectors using a 33 kg-yr exposure collected between January, 2017 and November, 2019. A temporal-energy analysis gives a new limit on the axion-photon coupling as g_{aγ}
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- 2022
69. Experimental study of C13(α,n)O16 reactions in the Majorana Demonstrator calibration data
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Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Bhimani, KH, Blalock, E, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cuesta, C, Detwiler, JA, Efremenko, Yu, Ejiri, H, Elliott, SR, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Henning, R, Aguilar, D Hervas, Hoppe, EW, Hostiuc, A, Kidd, MF, Kim, I, Kouzes, RT, Lannen, TE, Li, A, Lopez, AM, López-Castaño, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Oli, TK, Othman, G, Paudel, LS, Pettus, W, Poon, AWP, Radford, DC, Reine, AL, Rielage, K, Ruof, NW, Tedeschi, D, Varner, RL, Vasilyev, S, Wilkerson, JF, Wiseman, C, Xu, W, Yu, C-H, and Zhu, BX
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Nuclear and Plasma Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Nuclear and plasma physics - Abstract
Neutron captures and delayed decays of reaction products are common sources of backgrounds in ultrarare event searches. In this work, we studied C13(α,n)O16 reactions induced by α particles emitted within the calibration sources of the Majorana Demonstrator. These sources are thorium-based calibration standards enclosed in carbon-rich materials. The reaction rate was estimated by using the 6129-keV γ rays emitted from the excited O16 states that are populated when the incoming α particles exceed the reaction Q value. Thanks to the excellent energy performance of the Demonstrator's germanium detectors, these characteristic photons can be clearly observed in the calibration data. Facilitated by Geant4 simulations, a comparison between the observed 6129-keV photon rates and predictions by a talys-based software was performed. The measurements and predictions were found to be consistent, albeit with large statistical uncertainties. This agreement provides support for background projections from (α,n) reactions in future double-beta decay search efforts.
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- 2022
70. The MAJORANA DEMONSTRATOR Readout Electronics System
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Abgrall, N., Amman, M., Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Barton, P. J., Bertrand, F. E., Bhimani, K. H., Bos, B., Bradley, A. W., Burritt, T. H., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cooper, R. J., Cuesta, C., Detwiler, J. A., Drobizhev, A., Edwins, D. W., Efremenko, Yu., Ejiri, H., Elliott, S. R., Gilliss, T., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Hegedus, R. J., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Li, A., Loach, J. C., Lopez, A. M., López-Castaño, J. M., Luke, P. N., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Myslik, J., Oli, T. K., Othman, G., Peterson, D., Pettus, W., Poon, A. W. P., Radford, D. C., Rager, J., Reine, A. L., Rielage, K., Robertson, R. G. H., Ruof, N. W., Sayki, B., Stortini, M. J., Tedeschi, D., Turqueti, M., Van Wechel, T. D., Varner, R. L., Vasilyev, S., Vetter, K., Wilkerson, J. F., Wiseman, C., Xu, W., Yaver, H., Yu, C. -H., Zhu, B. X., and Zimmermann, S.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
The MAJORANA DEMONSTRATOR comprises two arrays of high-purity germanium detectors constructed to search for neutrinoless double-beta decay in 76-Ge and other physics beyond the Standard Model. Its readout electronics were designed to have low electronic noise, and radioactive backgrounds were minimized by using low-mass components and low-radioactivity materials near the detectors. This paper provides a description of all components of the MAJORANA DEMONSTRATOR readout electronics, spanning the front-end electronics and internal cabling, back-end electronics, digitizer, and power supplies, along with the grounding scheme. The spectroscopic performance achieved with these readout electronics is also demonstrated., Comment: For submission to JINST, 17 figures. v2: revised version
- Published
- 2021
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- View/download PDF
71. Signatures of muonic activation in the Majorana Demonstrator
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bertrand, F. E., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Edwards, T. R., Efremenko, Yu., Ejiri, H., Elliott, S. R., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lannen V, T. E., Lopez, A. M., López-Castaño, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Oli, T. K., Othman, G., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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Nuclear Experiment ,Physics - Instrumentation and Detectors - Abstract
Experiments searching for very rare processes such as neutrinoless double-beta decay require a detailed understanding of all sources of background. Signals from radioactive impurities present in construction and detector materials can be suppressed using a number of well-understood techniques. Background from in-situ cosmogenic interactions can be reduced by siting an experiment deep underground. However, the next generation of such experiments have unprecedented sensitivity goals of 10$^{28}$ years half-life with background rates of 10$^{-5}$cts/(keV kg yr) in the region of interest. To achieve these goals, the remaining cosmogenic background must be well understood. In the work presented here, Majorana Demonstrator data is used to search for decay signatures of meta-stable germanium isotopes. Contributions to the region of interest in energy and time are estimated using simulations, and compared to Demonstrator data. Correlated time-delayed signals are used to identify decay signatures of isotopes produced in the germanium detectors. A good agreement between expected and measured rate is found and different simulation frameworks are used to estimate the uncertainties of the predictions. The simulation campaign is then extended to characterize the background for the LEGEND experiment, a proposed tonne-scale effort searching for neutrinoless double-beta decay in $^{76}$Ge., Comment: 14 pages, 12 figures
- Published
- 2021
- Full Text
- View/download PDF
72. Erratum to: Search for exclusive Higgs and Z boson decays to ϕγ and ργ with the ATLAS detector
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Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B., Abidi, S. H., AbouZeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abreu, R., Abulaiti, Y., Acharya, B. S., Adachi, S., Adamczyk, L., Adelman, J., Adersberger, M., Adye, T., Affolder, A. A., Afik, Y., Agatonovic-Jovin, T., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahlen, S. P., Ahmadov, F., Aielli, G., Akatsuka, S., Akerstedt, H., Åkesson, T. P. A., Akilli, E., Akimov, A. V., Alberghi, G. L., Albert, J., Albicocco, P., Alconada Verzini, M. J., Alderweireldt, S. C., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexander, G., Alexopoulos, T., Alhroob, M., Ali, B., Aliev, M., Alimonti, G., Alison, J., Alkire, S. P., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, A., Alonso, F., Alpigiani, C., Alshehri, A. A., Alstaty, M. I., Alvarez Gonzalez, B., Álvarez Piqueras, D., Alviggi, M. G., Amadio, B. T., Amaral Coutinho, Y., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amundsen, G., Anastopoulos, C., Ancu, L. S., Andari, N., Andeen, T., Anders, C. F., Anders, J. K., Anderson, K. J., Andreazza, A., Andrei, V., Angelidakis, S., Angelozzi, I., Angerami, A., Anisenkov, A. V., Anjos, N., Annovi, A., Antel, C., Antonelli, M., Antonov, A., Antrim, D. J., Anulli, F., Aoki, M., Aperio Bella, L., Arabidze, G., Arai, Y., Araque, J. P., Araujo Ferraz, V., Arce, A. T. H., Ardell, R. E., Arduh, F. A., Arguin, J-F., Argyropoulos, S., Arik, M., Armbruster, A. J., Armitage, L. J., Arnaez, O., Arnold, H., Arratia, M., Arslan, O., Artamonov, A., Artoni, G., Artz, S., Asai, S., Asbah, N., Ashkenazi, A., Asquith, L., Assamagan, K., Astalos, R., Atkinson, M., Atlay, N. B., Augsten, K., Avolio, G., Axen, B., Ayoub, M. K., Azuelos, G., Baas, A. E., Baca, M. J., Bachacou, H., Bachas, K., Backes, M., Bagnaia, P., Bahmani, M., Bahrasemani, H., Baines, J. T., Bajic, M., Baker, O. K., Bakker, P. J., Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Banas, E., Bandyopadhyay, A., Banerjee, Sw., Bannoura, A. A. E., Barak, L., Barberio, E. L., Barberis, D., Barbero, M., Barillari, T., Barisits, M.-S., Barkeloo, J. T., Barklow, T., Barlow, N., Barnes, S. L., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimarães da Costa, J., Bartoldus, R., Barton, A. E., Bartos, P., Basalaev, A., Bassalat, A., Bates, R. L., Batista, S. J., Batley, J. R., Battaglia, M., Bauce, M., Bauer, F., Bawa, H. S., Beacham, J. B., Beattie, M. D., Beau, T., Beauchemin, P. H., Bechtle, P., Beck, H. P., Beck, H. C., Becker, K., Becker, M., Becot, C., Beddall, A. J., Beddall, A., Bednyakov, V. A., Bedognetti, M., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behr, J. K., Bell, A. S., Bella, G., Bellagamba, L., Bellerive, A., Bellomo, M., Belotskiy, K., Beltramello, O., Belyaev, N. L., Benary, O., Benchekroun, D., Bender, M., Benekos, N., Benhammou, Y., Benhar Noccioli, E., Benitez, J., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Bergsten, L. J., Beringer, J., Berlendis, S., Bernard, N. R., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Bertella, C., Bertoli, G., Bertram, I. A., Bertsche, C., Besjes, G. J., Bessidskaia Bylund, O., Bessner, M., Besson, N., Bethani, A., Bethke, S., Betti, A., Bevan, A. J., Beyer, J., Bianchi, R. M., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N. V., Biglietti, M., Billoud, T. R. V., Bilokon, H., Bindi, M., Bingul, A., Bini, C., Biondi, S., Bisanz, T., Bittrich, C., Bjergaard, D. M., Black, J. E., Black, K. M., Blair, R. E., Blazek, T., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Blunier, Dr., Bobbink, G. J., Bobrovnikov, V. S., Bocchetta, S. S., Bocci, A., Bock, C., Boehler, M., Boerner, D., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Boldyrev, A. S., Bolz, A. E., Bomben, M., Bona, M., Boonekamp, M., Borisov, A., Borissov, G., Bortfeldt, J., Bortoletto, D., Bortolotto, V., Boscherini, D., Bosman, M., Bossio Sola, J. D., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Bourdarios, C., Boutle, S. K., Boveia, A., Boyd, J., Boyko, I. R., Bozson, A. J., Bracinik, J., Brandt, A., Brandt, G., Brandt, O., Braren, F., Bratzler, U., Brau, B., Brau, J. E., Breaden Madden, W. D., Brendlinger, K., Brennan, A. J., Brenner, L., Brenner, R., Bressler, S., Briglin, D. L., Bristow, T. M., Britton, D., Britzger, D., Brochu, F. M., Brock, I., Brock, R., Brooijmans, G., Brooks, T., Brooks, W. K., Brosamer, J., Brost, E., Broughton, J. H., Bruckman de Renstrom, P. A., Bruncko, D., Bruni, A., Bruni, G., Bruni, L. S., Bruno, S., Brunt, B. H., Bruschi, M., Bruscino, N., Bryant, P., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Buehrer, F., Bugge, M. K., Bulekov, O., Bullock, D., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burka, K., Burke, S., Burmeister, I., Burr, J. T. P., Büscher, D., Büscher, V., Bussey, P., Butler, J. M., Buttar, C. M., Butterworth, J. M., Butti, P., Buttinger, W., Buzatu, A., Buzykaev, A. R., Cabrera Urbán, S., Caforio, D., Cai, H., Cairo, V. M., Cakir, O., Calace, N., Calafiura, P., Calandri, A., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Calvente Lopez, S., Calvet, D., Calvet, S., Calvet, T. P., Camacho Toro, R., Camarda, S., Camarri, P., Cameron, D., Caminal Armadans, R., Camincher, C., Campana, S., Campanelli, M., Camplani, A., Campoverde, A., Canale, V., Cano Bret, M., Cantero, J., Cao, T., Capeans Garrido, M. D. M., Caprini, I., Caprini, M., Capua, M., Carbone, R. M., Cardarelli, R., Cardillo, F., Carli, I., Carli, T., Carlino, G., Carlson, B. T., Carminati, L., Carney, R. M. D., Caron, S., Carquin, E., Carrá, S., Carrillo-Montoya, G. D., Casadei, D., Casado, M. P., Casha, A. F., Casolino, M., Casper, D. W., Castelijn, R., Castillo Gimenez, V., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Caudron, J., Cavaliere, V., Cavallaro, E., Cavalli, D., Cavalli-Sforza, M., Cavasinni, V., Celebi, E., Ceradini, F., Cerda Alberich, L., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chafaq, A., Chakraborty, D., Chan, S. K., Chan, W. S., Chan, Y. L., Chang, P., Chapman, J. D., Charlton, D. G., Chau, C. C., Chavez Barajas, C. A., Che, S., Cheatham, S., Chegwidden, A., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chelstowska, M. A., Chen, C., Chen, C., Chen, H., Chen, J., Chen, S., Chen, S., Chen, X., Chen, Y., Cheng, H. C., Cheng, H. J., Cheplakov, A., Cheremushkina, E., Cherkaoui El Moursli, R., Cheu, E., Cheung, K., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, Y. H., Chizhov, M. V., Choi, K., Chomont, A. R., Chouridou, S., Chow, Y. S., Christodoulou, V., Chu, M. C., Chudoba, J., Chuinard, A. J., Chwastowski, J. J., Chytka, L., Ciftci, A. K., Cinca, D., Cindro, V., Cioară, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Ciubancan, M., Clark, A., Clark, B. L., Clark, M. R., Clark, P. J., Clarke, R. N., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Colasurdo, L., Cole, B., Colijn, A. P., Collot, J., Colombo, T., Conde Muiño, P., Coniavitis, E., Connell, S. H., Connelly, I. A., Constantinescu, S., Conti, G., Conventi, F., Cooke, M., Cooper-Sarkar, A. M., Cormier, F., Cormier, K. J. R., Corradi, M., Corriveau, F., Cortes-Gonzalez, A., Costa, G., Costa, M. J., Costanzo, D., Cottin, G., Cowan, G., Cox, B. E., Cranmer, K., Crawley, S. J., Creager, R. A., Cree, G., Crépé-Renaudin, S., Crescioli, F., Cribbs, W. A., Cristinziani, M., Croft, V., Crosetti, G., Cueto, A., Cuhadar Donszelmann, T., Cukierman, A. R., Cummings, J., Curatolo, M., Cúth, J., Czekierda, S., Czodrowski, P., D’amen, G., D’Auria, S., D’eramo, L., D’Onofrio, M., Da Cunha Sargedas De Sousa, M. J., Da Via, C., Dabrowski, W., Dado, T., Dai, T., Dale, O., Dallaire, F., Dallapiccola, C., Dam, M., Dandoy, J. R., Daneri, M. F., Dang, N. P., Daniells, A. C., Dann, N. S., Danninger, M., Dano Hoffmann, M., Dao, V., Darbo, G., Darmora, S., Dassoulas, J., Dattagupta, A., Daubney, T., Davey, W., David, C., Davidek, T., Davis, D. R., Davison, P., Dawe, E., Dawson, I., De, K., de Asmundis, R., De Benedetti, A., De Castro, S., De Cecco, S., De Groot, N., de Jong, P., De la Torre, H., De Lorenzi, F., De Maria, A., De Pedis, D., De Salvo, A., De Sanctis, U., De Santo, A., De Vasconcelos Corga, K., De Vivie De Regie, J. B., Debbe, R., Debenedetti, C., Dedovich, D. 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73. Decadal stability in coral cover could mask hidden changes on reefs in the East Asian Seas
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Chan, Y. K. S., Affendi, Y. A., Ang, P. O., Baria-Rodriguez, M. V., Chen, C. A., Chui, A. P. Y., Giyanto, Glue, M., Huang, H., Kuo, C-Y., Kim, S. W., Lam, V. Y. Y., Lane, D. J. W., Lian, J. S., Lin, S. M. N. N., Lunn, Z., Nañola, Jr, C. L., Nguyen, V. L., Park, H. S., Suharsono, Sutthacheep, M., Vo, S. T., Vibol, O., Waheed, Z., Yamano, H., Yeemin, T., Yong, E., Kimura, T., Tun, K., Chou, L. M., and Huang, D.
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- 2023
- Full Text
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74. The Majorana Demonstrator readout electronics system
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Abgrall, N, Amman, M, Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Barton, PJ, Bertrand, FE, Bhimani, KH, Bos, B, Bradley, AW, Burritt, TH, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cooper, RJ, Cuesta, C, Detwiler, JA, Drobizhev, A, Edwins, DW, Efremenko, Yu, Ejiri, H, Elliott, SR, Gilliss, T, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Hegedus, RJ, Henning, R, Aguilar, D Hervas, Hoppe, EW, Hostiuc, A, Kidd, MF, Kim, I, Kouzes, RT, Li, A, Loach, JC, Lopez, AM, López-Castaño, JM, Luke, PN, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Mertens, S, Myslik, J, Oli, TK, Othman, G, Peterson, D, Pettus, W, Poon, AWP, Radford, DC, Rager, J, Reine, AL, Rielage, K, Robertson, RGH, Ruof, NW, Sayki, B, Stortini, MJ, Tedeschi, D, Turqueti, M, Van Wechel, TD, Varner, RL, Vasilyev, S, Vetter, K, Wilkerson, JF, Wiseman, C, Xu, W, Yaver, H, Yu, C-H, Zhu, BX, and Zimmermann, S
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Nuclear and Plasma Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Double-beta decay detectors ,Electronic detector readout concepts ,Front-end electronics for detector readout ,Engineering ,Nuclear & Particles Physics ,Physical sciences - Abstract
The Majorana Demonstrator comprises two arrays of high-purity germanium detectors constructed to search for neutrinoless double-beta decay in 76Ge and other physics beyond the Standard Model. Its readout electronics were designed to have low electronic noise, and radioactive backgrounds were minimized by using low-mass components and low-radioactivity materials near the detectors. This paper provides a description of all components of the Majorana Demonstrator readout electronics, spanning the front-end electronics and internal cabling, back-end electronics, digitizer, and power supplies, along with the grounding scheme. The spectroscopic performance achieved with these readout electronics is also demonstrated.
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- 2022
75. Dimensional crossover and symmetry transformation of charge density waves in VSe2
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Chen, P, Chan, Y-H, Liu, R-Y, Zhang, HT, Gao, Q, Fedorov, A-V, Chou, MY, and Chiang, T-C
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Physical Sciences ,Chemical Sciences ,Engineering ,Fluids & Plasmas - Abstract
Collective phenomena in solids can be sensitive to the dimensionality of the system; a case of special interest is VSe2, which shows a (7×3) charge density wave (CDW) in the single layer with threefold symmetry in the normal phase spontaneously broken, in contrast to the (4×4) in-plane CDW in the bulk. Angle-resolved photoemission spectroscopy (ARPES) from VSe2 ranging from a single layer to the bulk reveals the evolution of the electronic structure including the Fermi surface contours and the CDW gap. At a thickness of two layers, the ARPES maps are already nearly bulklike, but the transition temperature TC for the (4×4) CDW is much higher than the bulk value of 110 K. These results can be understood as due to dimensional crossover of phonon instability driven by a competition of nesting vectors. In this letter, we provide key insights into the CDW mechanisms and offer a perspective in the search and control of emergent phases in quantum materials.
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- 2022
76. α-event characterization and rejection in point-contact HPGe detectors
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Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Bertrand, FE, Blalock, E, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cuesta, C, Detwiler, JA, Drobizhev, A, Edwards, TR, Edwins, DW, Edzards, F, Efremenko, Y, Elliott, SR, Gilliss, T, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Hegedus, RJ, Henning, R, Aguilar, D Hervas, Hoppe, EW, Hostiuc, A, Kim, I, Kouzes, RT, Lopez, AM, López-Castaño, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Mertens, S, Myslik, J, Oli, TK, Othman, G, Pettus, W, Poon, AWP, Radford, DC, Rager, J, Reine, AL, Rielage, K, Ruof, NW, Saykı, B, Schönert, S, Stortini, MJ, Tedeschi, D, Varner, RL, Vasilyev, S, Wilkerson, JF, Willers, M, Wiseman, C, Xu, W, Yu, C-H, and Zhu, BX
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Nuclear and Plasma Physics ,Particle and High Energy Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Clinical Research ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Quantum Physics ,Nuclear & Particles Physics ,Astronomical sciences ,Atomic ,molecular and optical physics ,Particle and high energy physics - Abstract
P-type point contact (PPC) HPGe detectors are a leading technology for rare event searches due to their excellent energy resolution, low thresholds, and multi-site event rejection capabilities. We have characterized a PPC detector's response to α particles incident on the sensitive passivated and p + surfaces, a previously poorly-understood source of background. The detector studied is identical to those in the Majorana Demonstrator experiment, a search for neutrinoless double-beta decay ( 0νββ ) in 76 Ge. α decays on most of the passivated surface exhibit significant energy loss due to charge trapping, with waveforms exhibiting a delayed charge recovery (DCR) signature caused by the slow collection of a fraction of the trapped charge. The DCR is found to be complementary to existing methods of α identification, reliably identifying α background events on the passivated surface of the detector. We demonstrate effective rejection of all surface α events (to within statistical uncertainty) with a loss of only 0.2% of bulk events by combining the DCR discriminator with previously-used methods. The DCR discriminator has been used to reduce the background rate in the 0νββ region of interest window by an order of magnitude in the Majorana Demonstrator and will be used in the upcoming LEGEND-200 experiment.
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- 2022
77. LEGEND-1000 Preconceptual Design Report
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LEGEND Collaboration, Abgrall, N., Abt, I., Agostini, M., Alexander, A., Andreoiu, C., Araujo, G. R., Avignone III, F. T., Bae, W., Bakalyarov, A., Balata, M., Bantel, M., Barabanov, I., Barabash, A. S., Barbeau, P. S., Barton, C. J., Barton, P. J., Baudis, L., Bauer, C., Bernieri, E., Bezrukov, L., Bhimani, K. H., Biancacci, V., Blalock, E., Bolozdynya, A., Borden, S., Bos, B., Bossio, E., Boston, A., Bothe, V., Bouabid, R., Boyd, S., Brugnera, R., Burlac, N., Busch, M., Caldwell, A., Caldwell, T. S., Carney, R., Cattadori, C., Chan, Y. -D., Chernogorov, A., Christofferson, C. D., Chu, P. -H., Clark, M., Cohen, T., Combs, D., Comellato, T., Cooper, R. J., Costa, I. A., D'Andrea, V., Detwiler, J. A., Di Giacinto, A., Di Marco, N., Dobson, J., Drobizhev, A., Durand, M. R., Edzards, F., Efremenko, Yu., Elliott, S. R., Engelhardt, A., Fajt, L., Faud, N., Febbraro, M. T., Ferella, F., Fields, D. E., Fischer, F., Fomina, M., Fox, H., Franchi, J., Gala, R., Galindo-Uribarri, A., Gangapshev, A., Garfagnini, A., Geraci, A., Gilbert, C., Gold, M., Gooch, C., Gradwohl, K. P., Green, M. P., Grinyer, G. F., Grobov, A., Gruszko, J., Guinn, I., Guiseppe, V. E., Gurentsov, V., Gurov, Y., Gusev, K., Hacket, B., Hagemann, F., Hakenmüeller, J., Haranczyk, M., Hauertmann, L., Haufe, C. R., Hayward, C., Heffron, B., Henkes, F., Henning, R., Aguilar, D. Hervas, Hinton, J., Hodak, R., Hoffmann, H., Hofmann, W., Hostiuc, A., Huang, J., Hult, M., Mirza, M. Ibrahim, Jochum, J., Jones, R., Judson, D., Junker, M., Kaizer, J., Kazalov, V., Kermaïdic, Y., Khushbakht, H., Kidd, M., Kihm, T., Kilgus, K., Kim, I., Klimenko, A., Knöpfle, K. T., Kochetov, O., Konovalov, S. I., Kontul, I., Kool, K., Kormos, L. L., Kornoukhov, V. N., Korosec, M., Krause, P., Kuzminov, V. V., López-Castaño, J. M., Lang, K., Laubenstein, M., León, E., Lehnert, B., Leonhardt, A., Li, A., Lindner, M., Lippi, I., Liu, X., Liu, J., Loomba, D., Lubashevskiy, A., Lubsandorzhiev, B., Lusardi, N., Müller, Y., Macko, M., Macolino, C., Majorovits, B., Mamedov, F., Maneschg, W., Manzanillas, L., Marshall, G., Martin, R. D., Martin, E. L., Massarczyk, R., Mei, D., Meijer, S. J., Mertens, S., Misiaszek, M., Mondragon, E., Morella, M., Morgan, B., Mroz, T., Muenstermann, D., Nave, C. J., Nemchenok, I., Neuberger, M., Oli, T. K., Gann, G. Orebi, Othman, G., Palušova, V., Panth, R., Papp, L., Paudel, L. S., Pelczar, K., Perez, J. Perez, Pertoldi, L., Pettus, W., Piseri, P., Poon, A. W. P., Povinec, P., Pullia, A., Radford, D. C., Ramachers, Y. A., Ransom, C., Rauscher, L., Redchuk, M., Reine, A. L., Riboldi, S., Rielage, K., Rozov, S., Rukhadze, E., Rumyantseva, N., Runge, J., Ruof, N. W., Saakyan, R., Sailer, S., Salamanna, G., Salamida, F., Salvat, D. J., Sandukovsky, V., Schönert, S., Schültz, A., Schütt, M., Schaper, D. C., Schreiner, J., Schulz, O., Schuster, M., Schwarz, M., Schwingenheuer, B., Selivanenko, O., Shafiee, M., Shevchik, E., Shirchenko, M., Shitov, Y., Simgen, H., Simkovic, F., Skorokhvatov, M., Slavickova, M., Smolek, K., Smolnikov, A., Solomon, J. A., Song, G., Starosta, K., Stekl, I., Stommel, M., Stukov, D., Sumathi, R. R., Sweigart, D. A., Szczepaniec, K., Taffarello, L., Tagnani, D., Tayloe, R., Tedeschi, D., Turqueti, M., Varner, R. L., Vasilyev, S., Veresnikova, A., Vetter, K., Vignoli, C., Vogl, C., von Sturm, K., Waters, D., Waters, J. C., Wei, W., Wiesinger, C., Wilkerson, J. F., Willers, M., Wiseman, C., Wojcik, M., Wu, V. H. -S., Xu, W., Yakushev, E., Ye, T., Yu, C. -H., Yumatov, V., Zaretski, N., Zeman, J., Zhitnikov, I., Zinatulina, D., Zschocke, A. -K., Zsigmond, A. J., Zuber, K., and Zuzel, G.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
We propose the construction of LEGEND-1000, the ton-scale Large Enriched Germanium Experiment for Neutrinoless $\beta \beta$ Decay. This international experiment is designed to answer one of the highest priority questions in fundamental physics. It consists of 1000 kg of Ge detectors enriched to more than 90% in the $^{76}$Ge isotope operated in a liquid argon active shield at a deep underground laboratory. By combining the lowest background levels with the best energy resolution in the field, LEGEND-1000 will perform a quasi-background-free search and can make an unambiguous discovery of neutrinoless double-beta decay with just a handful of counts at the decay $Q$ value. The experiment is designed to probe this decay with a 99.7%-CL discovery sensitivity in the $^{76}$Ge half-life of $1.3\times10^{28}$ years, corresponding to an effective Majorana mass upper limit in the range of 9-21 meV, to cover the inverted-ordering neutrino mass scale with 10 yr of live time.
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- 2021
78. Intake Design for an Atmosphere-Breathing Electric Propulsion System (ABEP)
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Romano, F., Espinosa-Orozco, J., Pfeiffer, M., Herdrich, G., Crisp, N. H., Roberts, P. C. E., Holmes, B. E. A., Edmondson, S., Haigh, S., Livadiotti, S., Macario-Rojas, A., Oiko, V. T. A., Sinpetru, L. A., Smith, K., Becedas, J., Sulliotti-Linner, V., Bisgaard, M., Christensen, S., Hanessian, V., Jensen, T. Kauffman, Nielsen, J., Chan, Y. -A., Fasoulas, S., Traub, C., García-Almiñana, D., Rodríguez-Donaire, S., Sureda, M., Kataria, D., Belkouchi, B., Conte, A., Seminari, S., and Villain, R.
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Physics - Space Physics - Abstract
Challenging space missions include those at very low altitudes, where the atmosphere is source of aerodynamic drag on the spacecraft. To extend the lifetime of such missions, an efficient propulsion system is required. One solution is Atmosphere-Breathing Electric Propulsion (ABEP) that collects atmospheric particles to be used as propellant for an electric thruster. The system would minimize the requirement of limited propellant availability and can also be applied to any planetary body with atmosphere, enabling new missions at low altitude ranges for longer times. IRS is developing, within the H2020 DISCOVERER project, an intake and a thruster for an ABEP system. The article describes the design and simulation of the intake, optimized to feed the radio frequency (RF) Helicon-based plasma thruster developed at IRS. The article deals in particular with the design of intakes based on diffuse and specular reflecting materials, which are analysed by the PICLas DSMC-PIC tool. Orbital altitudes $h=150-250$ km and the respective species based on the NRLMSISE-00 model (O, $N_2$, $O_2$, He, Ar, H, N) are investigated for several concepts based on fully diffuse and specular scattering, including hybrid designs. The major focus has been on the intake efficiency defined as $\eta_c=\dot{N}_{out}/\dot{N}_{in}$, with $\dot{N}_{in}$ the incoming particle flux, and $\dot{N}_{out}$ the one collected by the intake. Finally, two concepts are selected and presented providing the best expected performance for the operation with the selected thruster. The first one is based on fully diffuse accommodation yielding to $\eta_c<0.46$ and the second one based un fully specular accommodation yielding to $\eta_c<0.94$. Finally, also the influence of misalignment with the flow is analysed, highlighting a strong dependence of $\eta_c$ in the diffuse-based intake while, ..., Comment: Accepted Version
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- 2021
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79. Impact of Exercise and Cognitive Stimulation Therapy on Physical Function, Cognition and Muscle Mass in Pre-Frail Older Adults in the Primary Care Setting: A Cluster Randomized Controlled Trial
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Tan, L. F., Chan, Y. H., Seetharaman, S., Denishkrshna, A., Au, L., Kwek, S. C., Chen, M. Z., Ng, S. E., Hui, R. J. Y., and Merchant, Reshma A.
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- 2023
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80. Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: “What's Past Is Prologue” (Shakespeare)CLL/SLL Unmet Need
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Mato, Anthony R, Davids, Matthew S, Sharman, Jeff, Roeker, Lindsey E, Kay, Neil, Kater, Arnon P, Rogers, Kerry, Thompson, Meghan C, Rhodes, Joanna, Goy, Andre, Skarbnik, Alan, Schuster, Stephen J, Tam, Constantine S, Eyre, Toby A, O'Brien, Susan, Nabhan, Chadi, Lamanna, Nicole, Sun, Clare, Shadman, Mazyar, Pagel, John M, Ujjani, Chaitra, Brander, Danielle, Coombs, Catherine C, Jain, Nitin, Cheah, Chan Y, Brown, Jennifer R, Seymour, John F, and Woyach, Jennifer A
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Rare Diseases ,Clinical Research ,Hematology ,Lymphoma ,Cancer ,Humans ,Immunotherapy ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Phosphatidylinositol 3-Kinases ,Protein Kinase Inhibitors ,Oncology & Carcinogenesis ,Clinical sciences ,Oncology and carcinogenesis - Abstract
The management of chronic lymphocytic leukemia (CLL) has undergone unprecedented changes over the last decade. Modern targeted therapies are incorporated into clinical practice. Unfortunately, patients have begun to develop resistance or intolerance to multiple classes. Symptomatic patients previously treated with a BTK inhibitor (BTKi) and venetoclax represent a new and rapidly growing unmet need in CLL. Here, we define unmet needs in a modern treatment context. We also critically review the literature for PI3K inhibitors and chemoimmunotherapy and lack of data to support their utility following BTKis and venetoclax. Finally, we suggest opportunities to ensure the continued innovation for patients with CLL.
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- 2022
81. Signatures of muonic activation in the Majorana Demonstrator
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Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Bertrand, FE, Blalock, E, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cuesta, C, Detwiler, JA, Edwards, TR, Efremenko, Yu, Ejiri, H, Elliott, SR, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Henning, R, Aguilar, D Hervas, Hoppe, EW, Hostiuc, A, Kidd, MF, Kim, I, Kouzes, RT, Lannen, TEV, Lopez, AM, López-Castaño, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Mertens, S, Oli, TK, Othman, G, Paudel, LS, Pettus, W, Poon, AWP, Radford, DC, Reine, AL, Rielage, K, Ruof, NW, Tedeschi, D, Varner, RL, Vasilyev, S, Wilkerson, JF, Wiseman, C, Xu, W, Yu, C-H, and Zhu, BX
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Nuclear and Plasma Physics ,Particle and High Energy Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Nuclear and plasma physics - Abstract
Experiments searching for very rare processes such as neutrinoless double-beta decay require a detailed understanding of all sources of background. Signals from radioactive impurities present in construction and detector materials can be suppressed using a number of well-understood techniques. Background from in situ cosmogenic interactions can be reduced by siting an experiment deep underground. However, the next generation of such experiments have unprecedented sensitivity goals of 1028 years half-life with background rates of 10-5cts/(keV kg yr) in the region of interest. To achieve these goals, the remaining cosmogenic background must be well understood. In the work presented here, Majorana Demonstrator data are used to search for decay signatures of metastable germanium isotopes. Contributions to the region of interest in energy and time are estimated using simulations and compared to Demonstrator data. Correlated time-delayed signals are used to identify decay signatures of isotopes produced in the germanium detectors. A good agreement between expected and measured rate is found and different simulation frameworks are used to estimate the uncertainties of the predictions. The simulation campaign is then extended to characterize the background for the LEGEND experiment, a proposed tonne-scale effort searching for neutrinoless double-beta decay in Ge76.
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- 2022
82. GMAC: A Distributional Perspective on Actor-Critic Framework
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Nam, Daniel Wontae, Kim, Younghoon, and Park, Chan Y.
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Computer Science - Machine Learning - Abstract
In this paper, we devise a distributional framework on actor-critic as a solution to distributional instability, action type restriction, and conflation between samples and statistics. We propose a new method that minimizes the Cram\'er distance with the multi-step Bellman target distribution generated from a novel Sample-Replacement algorithm denoted SR($\lambda$), which learns the correct value distribution under multiple Bellman operations. Parameterizing a value distribution with Gaussian Mixture Model further improves the efficiency and the performance of the method, which we name GMAC. We empirically show that GMAC captures the correct representation of value distributions and improves the performance of a conventional actor-critic method with low computational cost, in both discrete and continuous action spaces using Arcade Learning Environment (ALE) and PyBullet environment.
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- 2021
83. In-Orbit Aerodynamic Coefficient Measurements using SOAR (Satellite for Orbital Aerodynamics Research)
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Crisp, N. H., Roberts, P. C. E., Livadiotti, S., Rojas, A. Macario, Oiko, V. T. A., Edmondson, S., Haigh, S. J., Holmes, B. E. A., Sinpetru, L. A., Smith, K. L., Becedas, J., Dominguez, R. M., Sulliotti-Linner, V., Christensen, S., Nielsen, J., Bisgaard, M., Chan, Y-A., Fasoulas, S., Herdrich, G. H., Romano, F., Traub, C., Garcia-Alminana, D., Rodriguez-Donaire, S., Sureda, M., Kataria, D., Belkouchi, B., Conte, A., Seminari, S., and Villain, R.
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Physics - Space Physics - Abstract
The Satellite for Orbital Aerodynamics Research (SOAR) is a CubeSat mission, due to be launched in 2021, to investigate the interaction between different materials and the atmospheric flow regime in very low Earth orbits (VLEO). Improving knowledge of the gas-surface interactions at these altitudes and identification of novel materials that can minimise drag or improve aerodynamic control are important for the design of future spacecraft that can operate in lower altitude orbits. Such satellites may be smaller and cheaper to develop or can provide improved Earth observation data or communications link-budgets and latency. Using precise orbit and attitude determination information and the measured atmospheric flow characteristics the forces and torques experienced by the satellite in orbit can be studied and estimates of the aerodynamic coefficients calculated. This paper presents the scientific concept and design of the SOAR mission. The methodology for recovery of the aerodynamic coefficients from the measured orbit, attitude, and in-situ atmospheric data using a least-squares orbit determination and free-parameter fitting process is described and the experimental uncertainty of the resolved aerodynamic coefficients is estimated. The presented results indicate that the combination of the satellite design and experimental methodology are capable of clearly illustrating the variation of drag and lift coefficient for differing surface incidence angle. The lowest uncertainties for the drag coefficient measurement are found at approximately 300 km, whilst the measurement of lift coefficient improves for reducing orbital altitude to 200 km., Comment: 19 pages, 11 figures. Accepted for publication in Acta Astronautica (2020-12-14)
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- 2020
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84. RCV2023 Challenges: Benchmarking Model Training and Inference for Resource-Constrained Deep Learning.
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Rishabh Tiwari, Arnav Chavan, Deepak K. Gupta, Gowreesh Mago, Animesh Gupta, Akash Gupta, Suraj Sharan, Yukun Yang, Shanwei Zhao, Shihao Wang, Youngjun Kwak, Seonghun Jeong, Yunseung Lee, Changick Kim, Subin Kim, Ganzorig Gankhuyag, Ho Jung, Junwhan Ryu, HaeMoon Kim, Byeong Hak Kim, Tu Vo, Sheir Zaheer, Alexander Holston, Chan Y. Park, Dheemant Dixit, Nahush Lele, Kushagra Bhushan, Debjani Bhowmick, Devanshu Arya, Sadaf Gulshad, Amirhossein Habibian, Amir Ghodrati, Babak Ehteshami Bejnordi, Jai Gupta 0001, Zhuang Liu 0003, Jiahui Yu, Dilip K. Prasad, and Zhiqiang Shen
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- 2023
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85. CAR T cells and time-limited ibrutinib as treatment for relapsed/refractory mantle cell lymphoma: the phase 2 TARMAC study
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Minson, Adrian, Hamad, Nada, Cheah, Chan Y., Tam, Constantine, Blombery, Piers, Westerman, David, Ritchie, David, Morgan, Huw, Holzwart, Nicholas, Lade, Stephen, Anderson, Mary Ann, Khot, Amit, Seymour, John F., Robertson, Molly, Caldwell, Imogen, Ryland, Georgina, Saghebi, Javad, Sabahi, Zahra, Xie, Jing, Koldej, Rachel, and Dickinson, Michael
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- 2024
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86. Outcomes for high-risk defining events in follicular lymphoma following frontline immunochemotherapy
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Tobin, Joshua W. D., Chikatamarla, Venkata A., Matic, Marko, Griffin, Alison, Chowdhury, Rakin, Salvaris, Ross, Goh, Amanda, Black, Harrison, Tong, Tsz Hung, Birks, Callum, Jain, Sanjiv, Goodall, Elizabeth, Sirdesai, Shreerang, Trevis, Thomas, Steinepreis, Elizabeth, Chen, Yiyang, Li, Li, Broadby, Glenn, Gutta, Naadir, Morris, Kirk, Cochrane, Tara, Trotman, Judith, Talaulikar, Dipti, Shortt, Jake, Hodges, Georgina, Hawkes, Eliza A., Cheah, Chan Y., Barraclough, Allison, Manos, Kate, Johnston, Anna, Royle, Jane, Mondello, Patrizia, Ansell, Stephen M., and Hapgood, Greg
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- 2024
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87. Elementary school teachers' satisfaction with their collaboration with counsellors: effects of teacher attitudes, teacher expectations and counsellor professional traits
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Tu, S. -F., primary and Chan, Y. -H., additional
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- 2023
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88. The Majorana Demonstrator's Search for Double-Beta Decay of $^{76}$Ge to Excited States of $^{76}$Se
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Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bertrand, F. E., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Drobizhev, A., Edwards, T. R., Edwins, D. W., Efremenko, Yu., Ejiri, H., Elliott, S. R., Gilliss, T., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lopez, A. M., López-Castaño, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Myslik, J., Oli, T. K., Othman, G., Paudel, L. S., Pettus, W., Poon, A. W. P., Radford, D. C., Reine, A. L., Rielage, K., Ruof, N. W., Saykı, B., Stortini, M. J., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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Nuclear Experiment - Abstract
The Majorana Demonstrator is a neutrinoless double-beta decay search consisting of a low-background modular array of high-purity germanium detectors, $\sim2/3$ of which are enriched to 88\% in $^{76}$Ge. The experiment is also searching for double-beta decay of $^{76}$Ge to excited states (e.s.) in $^{76}$Se. $^{76}$Ge can decay into three daughter states of $^{76}$Se, with clear event signatures consisting of a $\beta\beta$-decay followed by the prompt emission of one or two $\gamma$-rays. This results with high probability in multi-detector coincidences. The granularity of the Demonstrator detector array enables powerful discrimination of this event signature from backgrounds. Using 41.9~kg-y of isotopic exposure, the Demonstrator has set world leading limits for each e.s.\ decay of $^{76}$Ge, with 90\% CL lower half-life limits in the range of $(0.75-4.0)\times10^{24}$~y. In particular, for the $2\nu$ transition to the first $0^+$ e.s.\ of $^{76}$Se, a lower half-life limit of $7.5\times10^{23}$~y at 90\% CL was achieved., Comment: 16 pages, 11 figures
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- 2020
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89. The Benefits of Very Low Earth Orbit for Earth Observation Missions
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Crisp, N. H., Roberts, P. C. E., Livadiotti, S., Oiko, V. T. A., Edmondson, S., Haigh, S. J., Huyton, C., Sinpetru, L., Smith, K. L., Worrall, S. D., Becedas, J., Domínguez, R. M., González, D., Hanessian, V., Mølgaard, A., Nielsen, J., Bisgaard, M., Chan, Y. -A., Fasoulas, S., Herdrich, G. H., Romano, F., Traub, C., García-Almiñana, D., Rodríguez-Donaire, S., Sureda, M., Kataria, D., Outlaw, R., Belkouchi, B., Conte, A., Perez, J. S., Villain, R., Heißerer, B., and Schwalber, A.
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Physics - Space Physics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Very low Earth orbits (VLEO), typically classified as orbits below approximately 450 km in altitude, have the potential to provide significant benefits to spacecraft over those that operate in higher altitude orbits. This paper provides a comprehensive review and analysis of these benefits to spacecraft operations in VLEO, with parametric investigation of those which apply specifically to Earth observation missions. The most significant benefit for optical imaging systems is that a reduction in orbital altitude improves spatial resolution for a similar payload specification. Alternatively mass and volume savings can be made whilst maintaining a given performance. Similarly, for radar and lidar systems, the signal-to-noise ratio can be improved. Additional benefits include improved geospatial position accuracy, improvements in communications link-budgets, and greater launch vehicle insertion capability. The collision risk with orbital debris and radiation environment can be shown to be improved in lower altitude orbits, whilst compliance with IADC guidelines for spacecraft post-mission lifetime and deorbit is also assisted. Finally, VLEO offers opportunities to exploit novel atmosphere-breathing electric propulsion systems and aerodynamic attitude and orbit control methods. However, key challenges associated with our understanding of the lower thermosphere, aerodynamic drag, the requirement to provide a meaningful orbital lifetime whilst minimising spacecraft mass and complexity, and atomic oxygen erosion still require further research. Given the scope for significant commercial, societal, and environmental impact which can be realised with higher performing Earth observation platforms, renewed research efforts to address the challenges associated with VLEO operations are required., Comment: 23 pages, 19 figures. Accepted for publication in Progress in Aerospace Sciences (24-04-2020)
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- 2020
- Full Text
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90. Search for $hep$ solar neutrinos and the diffuse supernova neutrino background using all three phases of the Sudbury Neutrino Observatory
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Aharmim, B., Ahmed, S. N., Anthony, A. E., Barros, N., Beier, E. W., Bellerive, A., Beltran, B., Bergevin, M., Biller, S. D., Blucher, E., Bonventre, R., Boudjemline, K., Boulay, M. G., Cai, B., Callaghan, E. J., Caravaca, J., Chan, Y. D., Chauhan, D., Chen, M., Cleveland, B. T., Cox, G. A., Dai, X., Deng, H., Descamps, F. B., Detwiler, J. A., Doe, P. J., Doucas, G., Drouin, P. -L., Dunford, M., Elliott, S. R., Evans, H. C., Ewan, G. T., Farine, J., Fergani, H., Fleurot, F., Ford, R. J., Formaggio, J. A., Gagnon, N., Gilje, K., Goon, J. TM., Graham, K., Guillian, E., Habib, S., Hahn, R. L., Hallin, A. L., Hallman, E. D., Harvey, P. J., Hazama, R., Heintzelman, W. J., Heise, J., Helmer, R. L., Hime, A., Howard, C., Huang, M., Jagam, P., Jamieson, B., Jelley, N. A., Jerkins, M., Keeter, K. J., Klein, J. R., Kormos, L. L., Kos, M., Kraus, C., Krauss, C. B., Krüger, A., Kutter, T., Kyba, C. C. M., Labe, K., Land, B. J., Lange, R., LaTorre, A., Law, J., Lawson, I. T., Lesko, K. T., Leslie, J. R., Levine, I., Loach, J. C., MacLellan, R., Majerus, S., Mak, H. B., Maneira, J., Martin, R. D., Mastbaum, A., McCauley, N., McDonald, A. B., McGee, S. R., Miller, M. L., Monreal, B., Monroe, J., Nickel, B. G., Noble, A. J., O'Keeffe, H. M., Oblath, N. S., Okada, C. E., Ollerhead, R. W., Gann, G. D. Orebi, Oser, S. M., Ott, R. A., Peeters, S. J. M., Poon, A. W. P., Prior, G., Reitzner, S. D., Rielage, K., Robertson, B. C., Robertson, R. G. H., Schwendener, M. H., Secrest, J. A., Seibert, S. R., Simard, O., Sinclair, D., Skensved, P., Sonley, T. J., Stonehill, L. C., Tešić, G., Tolich, N., Tsui, T., Van Berg, R., VanDevender, B. A., Virtue, C. J., Wall, B. L., Waller, D., Tseung, H. Wan Chan, Wark, D. L., Wendland, J., West, N., Wilkerson, J. F., Wilson, J. R., Winchester, T., Wright, A., Yeh, M., Zhang, F., and Zuber, K.
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High Energy Physics - Experiment ,Nuclear Experiment - Abstract
A search has been performed for neutrinos from two sources, the $hep$ reaction in the solar $pp$ fusion chain and the $\nu_e$ component of the diffuse supernova neutrino background (DSNB), using the full dataset of the Sudbury Neutrino Observatory with a total exposure of 2.47 kton-years after fiducialization. The $hep$ search is performed using both a single-bin counting analysis and a likelihood fit. We find a best-fit flux that is compatible with solar model predictions while remaining consistent with zero flux, and set a one-sided upper limit of $\Phi_{hep} < 30\times10^{3}~\mathrm{cm}^{-2}~\mathrm{s}^{-1}$ [90% credible interval (CI)]. No events are observed in the DSNB search region, and we set an improved upper bound on the $\nu_e$ component of the DSNB flux of $\Phi^\mathrm{DSNB}_{\nu_e} < 19~\textrm{cm}^{-2}~\textrm{s}^{-1}$ (90% CI) in the energy range $22.9 < E_\nu < 36.9$~MeV., Comment: 11 pages, 6 figures
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- 2020
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91. $\alpha$-event Characterization and Rejection in Point-Contact HPGe Detectors
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The MAJORANA Collaboration, Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bertrand, F. E., Blalock, E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Drobizhev, A., Edwards, T. R., Edwins, D. W., Efremenko, Yu., Elliott, S. R., Gilliss, T., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Hegedus, R. J., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kim, I., Kouzes, R. T., Lopez, A. M., López-Castaño, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Myslik, J., Oli, T. K., Othman, G., Pettus, W., Poon, A. W. P., Radford, D. C., Rager, J., Reine, A. L., Rielage, K., Ruof, N. W., Saykı, B., Schönert, S., Stortini, M. J., Tedeschi, D., Varner, R. L., Vasilyev, S., Wilkerson, J. F., Willers, M., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
P-type point contact (PPC) HPGe detectors are a leading technology for rare event searches due to their excellent energy resolution, low thresholds, and multi-site event rejection capabilities. We have characterized a PPC detector's response to $\alpha$ particles incident on the sensitive passivated and p+ surfaces, a previously poorly-understood source of background. The detector studied is identical to those in the MAJORANA DEMONSTRATOR experiment, a search for neutrinoless double-beta decay ($0\nu\beta\beta$) in $^{76}$Ge. $\alpha$ decays on most of the passivated surface exhibit significant energy loss due to charge trapping, with waveforms exhibiting a delayed charge recovery (DCR) signature caused by the slow collection of a fraction of the trapped charge. The DCR is found to be complementary to existing methods of $\alpha$ identification, reliably identifying $\alpha$ background events on the passivated surface of the detector. We demonstrate effective rejection of all surface $\alpha$ events (to within statistical uncertainty) with a loss of only 0.2% of bulk events by combining the DCR discriminator with previously-used methods. The DCR discriminator has been used to reduce the background rate in the $0\nu\beta\beta$ region of interest window by an order of magnitude in the MAJORANA DEMONSTRATOR, and will be used in the upcoming LEGEND-200 experiment., Comment: Accepted for publication in European Journal of Physics C
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- 2020
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92. Stabilization of antiferromagnetism in 1T-Fe$_{0.05}$TaS$_2$
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Niu, Q., Zhang, W., Chan, Y. T., O'Farrell, E. C. T., Doganov, R., Yip, K. Y., Lai, Kwing To, Yu, W. C., Ozyilmaz, B., Stewart, G. R., Kim, J. S., and Goh, Swee K.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Superconductivity - Abstract
1T-TaS$_2$ is a prototypical charge-density-wave (CDW) system with a Mott insulating ground state. Usually, a Mott insulator is accompanied by an antiferromagnetic state. However, the antiferromagnetic order had never been observed in 1T-TaS$_2$. Here, we report the stabilization of the antiferromagnetic order by the intercalation of a small amount of Fe into the van der Waals gap of 1T-TaS$_2$, i.e. forming 1T-Fe$_{0.05}$TaS$_2$. Upon cooling from 300~K, the electrical resistivity increases with a decreasing temperature before reaching a maximum value at around 15~K, which is close to the Neel temperature determined from our magnetic susceptibility measurement. The antiferromagnetic state can be fully suppressed when the sample thickness is reduced, indicating that the antiferromagnetic order in Fe$_{0.05}$TaS$_2$ has a non-negligible three-dimensional character. For the bulk Fe$_{0.05}$TaS$_2$, a comparison of our high pressure electrical transport data with that of 1T-TaS$_2$ indicates that, at ambient pressure, Fe$_{0.05}$TaS$_2$ is in the nearly commensurate charge-density-wave (NCCDW) phase near the border of the Mott insulating state. The temperature-pressure phase diagram thus reveals an interesting decoupling of the antiferromagnetism from the Mott insulating state., Comment: Q. Niu and W. Zhang contributed equally to this work. 7 pages, 5 figures
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- 2020
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93. Beam test results of IHEP-NDL Low Gain Avalanche Detectors(LGAD)
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Xiao, S., Alderweireldt, S., Ali, S., Allaire, C., Agapopoulou, C., Atanov, N., Ayoub, M. K., Barone, G., Benchekroun, D., Buzatu, A., Caforio, D., García, L. Castillo, Chan, Y., Chen, H., Cindro, V., Ciucu, L., da Costa, J. Barreiro Guimarães, Cui, H., Miralles, F. Davó, Davydov, Y., d'Amen, G., de la Taille, C., Kiuchi, R., Fan, Y., Falou, A., Ferreira, A. S. C., Garau, M., Ge, J., Ghosh, A., Giacomini, G., Gkougkousis, E. L., Grieco, C., Guindon, S., Han, D., Han, S., Holmberg, M., Howard, A., Huang, Y., Jing, M., Khoulaki, Y., Kramberger, G., Kuwertz, E., Lefebvre, H., Leite, M., Leopold, A., Li, C., Li, Q., Liang, H., Liang, Z., Liu, B., Liu, J., Luthfi, A., Lyu, F., Malyukov, S., Mandić, I., Masetti, L., Mikuž, M., Nikolic, I., Polidori, L., Polifka, R., Posopkina, O., Qi, B., Ran, K., Reynolds, B. J. G., Rizzi, C., Manzano, M. Robles, Rossi, E., Rummler, A., Sacerdoti, S., Saito, G. T., Seguin-Moreau, N., Serin, L., Shan, L., Shi, L., Sjostrom, N. F., Ferreira, A. Soares Canas, Soengen, J., Stenzel, H., Szadaj, A. J., Tan, Y., Terzo, S., Thomas, J. O., Tolley, E., Tricoli, A., Trincaz-Duvoid, S., Wang, R., Wang, S. M., Wang, W., Wu, K., Shi, X., Yang, T., Yang, Y., Yu, C., Zhang, X., Zhao, L., Zhao, M., Zhao, Z., Zheng, X., and Zhuang, X.
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Physics - Instrumentation and Detectors - Abstract
To meet the timing resolution requirement of up-coming High Luminosity LHC (HL-LHC), a new detector based on the Low-Gain Avalanche Detector(LGAD), High-Granularity Timing Detector (HGTD), is under intensive research in ATLAS. Two types of IHEP-NDL LGADs(BV60 and BV170) for this update is being developed by Institute of High Energy Physics (IHEP) of Chinese Academic of Sciences (CAS) cooperated with Novel Device Laboratory (NDL) of Beijing Normal University and they are now under detailed study. These detectors are tested with $5GeV$ electron beam at DESY. A SiPM detector is chosen as a reference detector to get the timing resolution of LGADs. The fluctuation of time difference between LGAD and SiPM is extracted by fitting with a Gaussian function. Constant fraction discriminator (CFD) method is used to mitigate the effect of time walk. The timing resolution of $41 \pm 1 ps$ and $63 \pm 1 ps$ are obtained for BV60 and BV170 respectively.
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- 2020
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94. ADC Nonlinearity Correction for the MAJORANA DEMONSTRATOR
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Abgrall, N., Allmond, J. M., Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bertrand, F. E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Campbell, C. M., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Crawford, H. L., Cuesta, C., Detwiler, J. A., Drobizhev, A., Edwins, D. W., Efremenko, Yu., Ejiri, H., Elliott, S. R., Gilliss, T., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Hegedus, R. J., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lopez, A. M., Lopez-Castano, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Myslik, J., Oli, T. K., Othman, G., Pettus, W., Poon, A. W. P., Radford, D. C., Rager, J., Reine, A. L., Rielage, K., Ruof, N. W., Stortini, M. J., Tedeschi, D., Varner, R. L., Vasilyev, S., White, B. R., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., Zhu, B. X., and Shanks, B.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
Imperfections in analog-to-digital conversion (ADC) cannot be ignored when signal digitization requirements demand both wide dynamic range and high resolution, as is the case for the Majorana Demonstrator 76Ge neutrinoless double beta decay search. Enabling the experiment's high-resolution spectral analysis and efficient pulse shape discrimination required careful measurement and correction of ADC nonlinearites. A simple measurement protocol was developed that did not require sophisticated equipment or lengthy data taking campaigns. A slope-dependent hysteresis was observed and characterized. A correction applied to digitized waveforms prior to signal processing reduced the differential and integral nonlinearites by an order of magnitude, eliminating these as dominant contributions to the systematic energy uncertainty at the double-beta decay Q value.
- Published
- 2020
- Full Text
- View/download PDF
95. A Low Energy Rare Event Search with the Majorana Demonstrator
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MAJORANA Collaboration, Wiseman, C., Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bertrand, F. E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Clark, M. L., Cuesta, C., Detwiler, J. A., Drobizhev, A., Edwins, D. W., Efremenko, Yu., Ejiri, H., Elliott, S. R., Gilliss, T., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Hegedus, R. J., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lopez, A. M., Lopez-Castano, J. M., Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Myslik, J., Oli, T. K., Othman, G., Pettus, W., Poon, A. W. P., Radford, D. C., Rager, J., Reine, A. L., Rielage, K., Ruof, N. W., Sayki, B., Stortini, M. J., Tedeschi, D., Varner, R. L., Wilkerson, J. F., Xu, W., Yu, C. -H., and Zhu, B. X.
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Nuclear Experiment ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The MAJORANA DEMONSTRATOR is sensitive to rare events near its energy threshold, including bosonic dark matter, solar axions, and lightly ionizing particles. In this analysis, a novel training set of low energy small-angle Compton scatter events is used to determine the efficiency of pulse shape analysis cuts, and we present updated bosonic dark matter and solar axion results from an 11.17 kg-y dataset using a 5 keV analysis threshold., Comment: 4 pages, 4 figures. Proceedings of the 16th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2019), September 9-13, 2019, Toyama, Japan
- Published
- 2019
- Full Text
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96. Results of the MAJORANA DEMONSTRATOR's Search for Double-Beta Decay of $^{76}$Ge to Excited States of $^{76}$Se
- Author
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Guinn, I. S., Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bertrand, F. E., Bos, B., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P-H., Clark, M. L., Cuesta, C., Detwiler, J. A., Drobizhev, A., Edwins, D. W., Efremenko, Yu., Ejiri, H., Elliott, S. R., Gilliss, T., Giovanetti, G. K., Green, M. P., Gruszko, J., Guiseppe, V. E., Haufe, C. R., Hegedus, R. J., Henning, R., Aguilar, D. Hervas, Hoppe, E. W., Hostiuc, A., Kidd, M. F., Kim, I., Kouzes, R. T., Lopez, A. M., no, J. M. López-Casta, Martin, E. L., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Myslik, J., Oli, T. K., Othman, G., Pettus, W., Poon, A. W. P., Radford, D. C., Rager, J., Reine, A. L., Rielage, K., Ruof, N. W., Stortini, M. J., Tedeschi, D., Varner, R. L., Wilkerson, J. F., Wiseman, C., Xu, W., Yu, C. -H., and Zhu, B. X.
- Subjects
Nuclear Experiment - Abstract
The MAJORANA DEMONSTRATOR is searching for double-beta decay of $^{76}$Ge to excited states (E.S.) in $^{76}$Se using a modular array of high purity Germanium detectors. $^{76}$Ge can decay into three E.S.s of $^{76}$Se. The E.S. decays have a clear event signature consisting of a $\beta\beta$-decay with the prompt emission of one or two $\gamma$-rays, resulting in with high probability in a multi-site event. The granularity of the DEMONSTRATOR detector array enables powerful discrimination of this event signature from backgrounds. Using 21.3 kg-y of isotopic exposure, the DEMONSTRATOR has set world leading limits for each E.S. decay, with 90% CL lower half-life limits in the range of $(0.56-2.1)\cdot10^{24}$ y. In particular, for the $2\nu$ transition to the first $0^+$ E.S. of $^{76}$Se, a lower half-life limit of $0.68\cdot10^{24}$ at 90% CL was achieved.
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- 2019
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97. Onset and performance of a two layer oscillating heat pipe in a heat spreader
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Abdelnabi, Mohamed, Ewing, Dan, and Ching, Chan Y.
- Published
- 2023
- Full Text
- View/download PDF
98. ADC Nonlinearity Correction for the Majorana Demonstrator
- Author
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Abgrall, N, Allmond, JM, Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Bertrand, FE, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Campbell, CM, Chan, Y-D, Christofferson, CD, Chu, Pinghan, Clark, ML, Crawford, HL, Cuesta, C, Detwiler, JA, Drobizhev, A, Edwins, DW, Efremenko, Yu, Ejiri, H, Elliott, SR, Gilliss, T, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Hegedus, RJ, Henning, R, Aguilar, D Hervas, Hoppe, EW, Hostiuc, A, Kidd, MF, Kim, I, Kouzes, RT, Lopez, AM, Lopez-Castano, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Mertens, S, Myslik, J, Oli, TK, Othman, G, Pettus, W, Poon, AWP, Radford, DC, Rager, J, Reine, AL, Rielage, K, Ruof, NW, Stortini, MJ, Tedeschi, D, Varner, RL, Vasilyev, S, White, BR, Wilkerson, JF, Wiseman, C, Xu, W, Yu, C-H, Zhu, BX, and Shanks, B
- Subjects
Nuclear and Plasma Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Gamma-ray detectors ,neutrinoless double-beta decay ,physics.ins-det ,nucl-ex ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Other Physical Sciences ,Biomedical Engineering ,Nuclear & Particles Physics ,Nuclear and plasma physics - Abstract
Imperfections in analog-to-digital conversion (ADC) cannot be ignored when signal digitization requirements demand both wide dynamic range and high resolution, as is the case for the Majorana Demonstrator 76Ge neutrinoless double-beta decay search. Enabling the experiment's high-resolution spectral analysis and efficient pulse shape discrimination required careful measurement and correction of ADC nonlinearities. A simple measurement protocol was developed that did not require sophisticated equipment or lengthy data-taking campaigns. A slope-dependent hysteresis was observed and characterized. A correction applied to digitized waveforms prior to signal processing reduced the differential and integral nonlinearities by an order of magnitude, eliminating these as dominant contributions to the systematic energy uncertainty at the double-beta decay Q value.
- Published
- 2021
99. Mosunetuzumab monotherapy is active and tolerable in patients with relapsed/refractory diffuse large B-cell lymphoma
- Author
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Bartlett, Nancy L., Assouline, Sarit, Giri, Pratyush, Schuster, Stephen J., Cheah, Chan Y., Matasar, Matthew, Gregory, Gareth P., Yoon, Dok Hyun, Shadman, Mazyar, Fay, Keith, Yoon, Sung-Soo, Panizo, Carlos, Flinn, Ian, Johnston, Anna, Bosch, Francesc, Sehn, Laurie H., Wei, Michael C., Yin, Shen, To, Iris, Li, Chi-Chung, Huang, Huang, Kwan, Antonia, Penuel, Elicia, and Budde, Lihua E.
- Published
- 2023
- Full Text
- View/download PDF
100. Search for double-β decay of Ge76 to excited states of Se76 with the majorana demonstrator
- Author
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Arnquist, IJ, Avignone, FT, Barabash, AS, Barton, CJ, Bertrand, FE, Blalock, E, Bos, B, Busch, M, Buuck, M, Caldwell, TS, Chan, Y-D, Christofferson, CD, Chu, P-H, Clark, ML, Cuesta, C, Detwiler, JA, Drobizhev, A, Edwards, TR, Edwins, DW, Efremenko, Yu, Ejiri, H, Elliott, SR, Gilliss, T, Giovanetti, GK, Green, MP, Gruszko, J, Guinn, IS, Guiseppe, VE, Haufe, CR, Henning, R, Aguilar, D Hervas, Hoppe, EW, Hostiuc, A, Kidd, MF, Kim, I, Kouzes, RT, Lopez, AM, López-Castaño, JM, Martin, EL, Martin, RD, Massarczyk, R, Meijer, SJ, Mertens, S, Myslik, J, Oli, TK, Othman, G, Paudel, LS, Pettus, W, Poon, AWP, Radford, DC, Reine, AL, Rielage, K, Ruof, NW, Saykı, B, Stortini, MJ, Tedeschi, D, Varner, RL, Vasilyev, S, Wilkerson, JF, Wiseman, C, Xu, W, Yu, C-H, and Zhu, BX
- Subjects
Nuclear and Plasma Physics ,Particle and High Energy Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Nuclear and plasma physics - Abstract
The majorana demonstrator is a neutrinoless double-β decay search consisting of a low-background modular array of high-purity germanium detectors, ∼2/3 of which are enriched to 88% in Ge76. The experiment is also searching for double-beta decay of Ge76 to excited states (e.s.) in Se76. Ge76 can decay into three daughter states of Se76, with clear event signatures consisting of a ββ-decay followed by the prompt emission of one or two γ rays. This results with high probability in multi-detector coincidences. The granularity of the demonstrator detector array enables powerful discrimination of this event signature from backgrounds. Using 41.9 kg yr of isotopic exposure, the demonstrator has set world leading limits for each e.s. decay of Ge76, with 90% CL lower half-life limits in the range of (0.75-4.0)×1024 yr. In particular, for the 2ν transition to the first 0+ e.s. of Se76, a lower half-life limit of 7.5×1023 yr at 90% CL was achieved.
- Published
- 2021
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