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51. Non-invasive ambulatory blood pressure variability and cardiac baroreflec sensitivity

Author

Siche, J.P., Herpin, D., Asmar, R.G., Poncelet, P., Chamontin, B., Comparat, V., Gressin, V., Boutelant, S., Mallion, J.M., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]
Published
1995

54. [Ambulatory measurement of blood pressure and plasma catecholamines in the study of orthostatic hypotension]

Author

Chamontin B, Amar J, Bégasse F, Ma, Tran, Jean-Michel Senard, Jl, Montastruc, and Salvador M

Subjects
Adult, Male, Hypotension, Orthostatic, Catecholamines, Autonomic Nervous System Diseases, Posture, Humans, Female, Blood Pressure Monitoring, Ambulatory, Middle Aged, Aged, Circadian Rhythm
Abstract

The purpose of the study was to investigate the interest of ambulatory blood pressure (BP) monitoring (ABPM) and plasma catecholamines in the management of orthostatic hypotension (OH). Fifteen patients, 4 men, 11 females, 53.3 +/- 21.1 years old, with OH were included in the study: 7 with dysautonomia (G1) = multiple systemic atrophy, pure autonomic failure, OH in elderly people; 8 with OH from other origin (G2) = hypovolemia, neurodystonia, vaso-vagal syncope. ABPM and plasma catecholamines assays (HPLC) in lying then in standing position were carried out in all patients. BP was 131.2 +/- 31.9/78.1 +/- 12.0 mmHg in lying and 112.1 +/- 25.3/75.4 +/- 15.8 in standing position (n = 15). The systolic (S) standing-induced (delta) decrease in BP after 1 min and 10 min (delta SBP) correlated with standard-deviation and variation coefficient of mean SBP (r = 0.78, p0.01; r = 0.82, p0.01 for delta sBP 1 min and r = 0.80, p0.01; r = 0.81, p0.01 for delta sBP 10 min), but not with norepinephrine (NorE) or epinephrine levels. There was a significant correlation between diastolic nycthemeral BP variability expressed by mean night-time DBP/mean day-time DBP ratio/diastolic N/D) and standing-induced decrease in DBP after 1 min (r = 0.59, p0.05). delta SBP 1 min and 10 min, delta DBP 1 min (p = 0.02, p = 0.05, p = 0.01) and systolic and diastolic N/D (p = 0.02; p0.01) were significantly different in G1 and G2.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1994

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