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52. NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients

Author

Jandrey, Elisa H. F., Moura, Ricardo P., Andrade, Luciana N. S., Machado, Camila L., Campesato, Luiz Felipe, Leite, Katia Ramos M., Inoue, Lilian T., Asprino, Paula F., da Silva, Ana Paula M., de Barros, Alfredo Carlos S. D., Carvalho, Andre, de Lima, Vladmir C., Carraro, Dirce M., Brentani, Helena P., da Cunha, Isabela W., Soares, Fernando A., Parmigiani, Raphael B., Chammas, Roger, Camargo, Anamaria A., and Costa, Érico T.

Published
2019
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53. Data from ADAM23 Negatively Modulates αvβ3 Integrin Activation during Metastasis

Author

Verbisck, Newton V., primary, Costa, Érico T., primary, Costa, Fabrício F., primary, Cavalher, Felícia P., primary, Costa, Michele D.M., primary, Muras, Angelita, primary, Paixão, Valéria A., primary, Moura, Ricardo, primary, Granato, Mariana F., primary, Ierardi, Daniela F, primary, Machado, Tamara, primary, Melo, Fabiana, primary, Ribeiro, Karina B., primary, Cunha, Isabela W., primary, Lima, Vladmir C.C., primary, Maciel, Maria do Socorro, primary, Carvalho, André L., primary, Soares, Fernando F., primary, Zanata, Silvio, primary, Sogayar, Mari C., primary, Chammas, Roger, primary, and Camargo, Anamaria A., primary

Published
2023
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54. Supplementary Figure 2 from ADAM23 Negatively Modulates αvβ3 Integrin Activation during Metastasis

Author

Verbisck, Newton V., primary, Costa, Érico T., primary, Costa, Fabrício F., primary, Cavalher, Felícia P., primary, Costa, Michele D.M., primary, Muras, Angelita, primary, Paixão, Valéria A., primary, Moura, Ricardo, primary, Granato, Mariana F., primary, Ierardi, Daniela F, primary, Machado, Tamara, primary, Melo, Fabiana, primary, Ribeiro, Karina B., primary, Cunha, Isabela W., primary, Lima, Vladmir C.C., primary, Maciel, Maria do Socorro, primary, Carvalho, André L., primary, Soares, Fernando F., primary, Zanata, Silvio, primary, Sogayar, Mari C., primary, Chammas, Roger, primary, and Camargo, Anamaria A., primary

Published
2023
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55. Supplementary Table 1 from ADAM23 Negatively Modulates αvβ3 Integrin Activation during Metastasis

Author

Verbisck, Newton V., primary, Costa, Érico T., primary, Costa, Fabrício F., primary, Cavalher, Felícia P., primary, Costa, Michele D.M., primary, Muras, Angelita, primary, Paixão, Valéria A., primary, Moura, Ricardo, primary, Granato, Mariana F., primary, Ierardi, Daniela F, primary, Machado, Tamara, primary, Melo, Fabiana, primary, Ribeiro, Karina B., primary, Cunha, Isabela W., primary, Lima, Vladmir C.C., primary, Maciel, Maria do Socorro, primary, Carvalho, André L., primary, Soares, Fernando F., primary, Zanata, Silvio, primary, Sogayar, Mari C., primary, Chammas, Roger, primary, and Camargo, Anamaria A., primary

Published
2023
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56. Supplementary Figure 1 from ADAM23 Negatively Modulates αvβ3 Integrin Activation during Metastasis

Author

Verbisck, Newton V., primary, Costa, Érico T., primary, Costa, Fabrício F., primary, Cavalher, Felícia P., primary, Costa, Michele D.M., primary, Muras, Angelita, primary, Paixão, Valéria A., primary, Moura, Ricardo, primary, Granato, Mariana F., primary, Ierardi, Daniela F, primary, Machado, Tamara, primary, Melo, Fabiana, primary, Ribeiro, Karina B., primary, Cunha, Isabela W., primary, Lima, Vladmir C.C., primary, Maciel, Maria do Socorro, primary, Carvalho, André L., primary, Soares, Fernando F., primary, Zanata, Silvio, primary, Sogayar, Mari C., primary, Chammas, Roger, primary, and Camargo, Anamaria A., primary

Published
2023
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57. Supplementary Table 2 from ADAM23 Negatively Modulates αvβ3 Integrin Activation during Metastasis

Author

Verbisck, Newton V., primary, Costa, Érico T., primary, Costa, Fabrício F., primary, Cavalher, Felícia P., primary, Costa, Michele D.M., primary, Muras, Angelita, primary, Paixão, Valéria A., primary, Moura, Ricardo, primary, Granato, Mariana F., primary, Ierardi, Daniela F, primary, Machado, Tamara, primary, Melo, Fabiana, primary, Ribeiro, Karina B., primary, Cunha, Isabela W., primary, Lima, Vladmir C.C., primary, Maciel, Maria do Socorro, primary, Carvalho, André L., primary, Soares, Fernando F., primary, Zanata, Silvio, primary, Sogayar, Mari C., primary, Chammas, Roger, primary, and Camargo, Anamaria A., primary

Published
2023
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58. Supplementary Figure 3 from ADAM23 Negatively Modulates αvβ3 Integrin Activation during Metastasis

Author

Verbisck, Newton V., primary, Costa, Érico T., primary, Costa, Fabrício F., primary, Cavalher, Felícia P., primary, Costa, Michele D.M., primary, Muras, Angelita, primary, Paixão, Valéria A., primary, Moura, Ricardo, primary, Granato, Mariana F., primary, Ierardi, Daniela F, primary, Machado, Tamara, primary, Melo, Fabiana, primary, Ribeiro, Karina B., primary, Cunha, Isabela W., primary, Lima, Vladmir C.C., primary, Maciel, Maria do Socorro, primary, Carvalho, André L., primary, Soares, Fernando F., primary, Zanata, Silvio, primary, Sogayar, Mari C., primary, Chammas, Roger, primary, and Camargo, Anamaria A., primary

Published
2023
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60. Unraveling the peripheral and local role of inflammatory cytokines in glioblastoma survival

Author

Cavalheiro, Vitor J., primary, Campos, Ana Carolina P., additional, Lima, Luiz G.C.A., additional, Roça, Cairo Thomé, additional, Docema, Marcos Fernando L., additional, Lancellotti, Carmen Lucia P., additional, Martinez, Raquel C.R., additional, Pagano, Rosana L., additional, Chammas, Roger, additional, Teixeira, Manoel J., additional, Maldaun, Marcos V.C., additional, and Neville, Iuri S., additional

Published
2023
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63. Collagen V α1 Chain Decrease in Papillary Dermis from Early Systemic Sclerosis: A New Proposal in Cutaneous Fibrosis Molecular Structure

Author

de Morais, Jymenez, primary, Velosa, Ana Paula P., additional, Andrade, Priscila C., additional, Frediani, Denise, additional, Carrasco, Solange, additional, Queiroz, Zelita A. de Jesus, additional, Martin, Patrícia, additional, Saito, Renata F., additional, Elias, Vitória, additional, Goldenstein-Schainberg, Cláudia, additional, Chammas, Roger, additional, Sampaio-Barros, Percival D., additional, Capelozzi, Vera L., additional, and Teodoro, Walcy R., additional

Published
2022
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67. Melatonin Regulates the Daily Levels of Plasma Amino Acids, Acylcarnitines, Biogenic Amines, Sphingomyelins, and Hexoses in a Xenograft Model of Triple Negative Breast Cancer

Author

Junior, Rubens Paula, primary, Chuffa, Luiz Gustavo de Almeida, additional, Simão, Vinicius Augusto, additional, Sonehara, Nathália Martins, additional, Chammas, Roger, additional, Reiter, Russel J., additional, and Zuccari, Debora Aparecida Pires de Campos, additional

Published
2022
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68. Allergic sensitization and exposure to ambient air pollution beginning early in life lead to a COPD-like phenotype in young adult mice

Author

de Souza Xavier Costa, Natália, primary, Mirtes Teles, Aila, additional, de Brito, Jôse Mára, additional, de Barros Mendes Lopes, Thaís, additional, Calciolari Rossi, Renata, additional, Magalhães Arantes Costa, Fernanda, additional, Mangueira Saraiva-Romanholo, Beatriz, additional, Perini, Adenir, additional, Furuya, Tatiane Katsue, additional, Germán Murillo Carrasco, Alexis, additional, Matera Veras, Mariana, additional, Nascimento Saldiva, Paulo Hilário, additional, Chammas, Roger, additional, and Mauad, Thais, additional

Published
2022
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69. MG-Pe: A Novel Galectin-3 Ligand with Antimelanoma Properties and Adjuvant Effects to Dacarbazine

Author

Biscaia, Stellee M. P., primary, Pires, Cassiano, additional, Lívero, Francislaine A. R., additional, Bellan, Daniel L., additional, Bini, Israel, additional, Bustos, Silvina O., additional, Vasconcelos, Renata O., additional, Acco, Alexandra, additional, Iacomini, Marcello, additional, Carbonero, Elaine R., additional, Amstalden, Martin K., additional, Kubata, Fábio R., additional, Cummings, Richard D., additional, Dias-Baruffi, Marcelo, additional, Simas, Fernanda F., additional, Oliveira, Carolina C., additional, Freitas, Rilton A., additional, Franco, Célia Regina Cavichiolo, additional, Chammas, Roger, additional, and Trindade, Edvaldo S., additional

Published
2022
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70. Locking and Unlocking Thrombin Function Using Immunoquiescent Nucleic Acid Nanoparticles with Regulated Retention In Vivo

Author

Ke, Weina, primary, Chandler, Morgan, additional, Cedrone, Edward, additional, Saito, Renata F., additional, Rangel, Maria Cristina, additional, de Souza Junqueira, Mara, additional, Wang, Jian, additional, Shi, Da, additional, Truong, Nguyen, additional, Richardson, Melina, additional, Rolband, Lewis A., additional, Dréau, Didier, additional, Bedocs, Peter, additional, Chammas, Roger, additional, Dokholyan, Nikolay V., additional, Dobrovolskaia, Marina A., additional, and Afonin, Kirill A., additional

Published
2022
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74. miRNA and mRNA Expression Profiles Associated with Lymph Node Metastasis and Prognosis in Penile Carcinoma

Author

Murta, Claudio B., primary, Furuya, Tatiane K., additional, Carrasco, Alexis G. M., additional, Uno, Miyuki, additional, Sichero, Laura, additional, Villa, Luisa L., additional, Faraj, Sheila F., additional, Coelho, Rafael F., additional, Guglielmetti, Giuliano B., additional, Cordeiro, Mauricio D., additional, Leite, Katia R. M., additional, Nahas, William C., additional, Chammas, Roger, additional, and Pontes, José, additional

Published
2022
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76. A novel program of infiltrative control in astrocytomas: ADAM23 depletion promotes cell invasion by activating γ-Secretase and NOTCH1 signaling pathway

Author

Jandrey, Elisa Helena Farias, primary, Barnabé, Gabriela Filoso, additional, Asprino, Paula Fontes, additional, Santos, Natália Cristina, additional, Inoue, Lilian Tiemi, additional, Rozanski, Andrei, additional, Maldaun, Marcos, additional, Galante, Pedro Alexandre Favoretto, additional, Marie, Suely Kazue N, additional, Oba-Shinjo, Sueli Mieko, additional, Santos, Tiago Góss, additional, Chammas, Roger, additional, Lancellotti, Carmen Lucia Penteado, additional, Furnari, Frank B., additional, Camargo, Anamaria Aranha, additional, and Costa, Érico Tosoni, additional

Published
2022
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77. Perfil bioquímico y significado clínico de los genes de la vía MAPK /CINASA en el diagnóstico de neoplasias tiroides

Author

Santos, Joyce Nascimento, Silva, Raissa Monteiro da, Bhattacharjee, Tanmoy Tapobrata, Kulcsar, Marco Aurélio Vamondes, Uno, Miyuki, Chammas, Roger, and Canevari, Renata de Azevedo

Subjects
Thyroid, MAPK/KINASE, FTIR, Tireoide, Marcador molecular, Gene expression, Molecular marker, Expressão gênica, Espectroscopia, Tiroides, Spectroscopy, La expresion genica
Abstract

Thyroid neoplasms are the main types of endocrine malignancy, their incidence increasing in recent years. Routine diagnosis may present inconclusive results, leading to the need for using additional techniques that are more precise, such as molecular analysis. Therefore, it is essential to search for molecular markers for the diagnosis of these malignancies and their different histological types. The objective of this study was to identify diagnostic molecular markers for papillary thyroid carcinomas (PTC) and goiter lesions. For this, expression of genes belonging to the MAPK/KINASE pathway was assessed by the RT-qPCR technique. Additionally, complete biochemical profiles of the samples were obtained using Fourier transform infrared spectroscopy (FTIR). Results of RT-qPCR suggest that FOS, JUN, MAP2K6, CCNA1, SFN genes have the potential to be tumor markers of thyroid lesions, and the MAP2K6, CCNA1, SFN genes further have the potential to distinguish PTC samples from other thyroid lesions. FTIR results showed that PTC lesions can be distinguished from normal and benign tissues with 95.83% efficiency; changes in nucleic acids being the major classifying factor. Overall, results suggest potential of molecular and FTIR analysis in diagnosis of thyroid cancer. Las neoplasias tiroideas son los principales tipos de malignidad endocrina, incrementándose su incidencia en los últimos años. El diagnóstico de rutina puede presentar resultados no concluyentes, lo que obliga a utilizar técnicas adicionales más precisas, como el análisis molecular. Por lo tanto, es fundamental la búsqueda de marcadores moleculares para el diagnóstico de estas neoplasias malignas y sus diferentes tipos histológicos. El objetivo de este estudio fue identificar marcadores moleculares de diagnóstico para carcinomas papilares de tiroides (CPT) y lesiones de bocio. Para ello, se evaluó la expresión de genes pertenecientes a la vía MAPK/KINASE mediante la técnica RT-qPCR. Además, se obtuvieron perfiles bioquímicos completos de las muestras mediante espectroscopia infrarroja transformada de Fourier (FTIR). Los resultados de RT-qPCR sugieren que los genes FOS, JUN, MAP2K6, CCNA1, SFN tienen el potencial de ser marcadores tumorales de lesiones tiroideas, y los genes MAP2K6, CCNA1, SFN tienen además el potencial de distinguir muestras de CPT de otras lesiones tiroideas. Los resultados de FTIR mostraron que las lesiones de CPT se pueden distinguir de los tejidos normales y benignos con una eficiencia del 95,83 %; siendo los cambios en los ácidos nucleicos el principal factor de clasificación. En general, los resultados sugieren el potencial del análisis molecular y FTIR en el diagnóstico del cáncer de tiroides. As neoplasias da tireoide são os principais tipos de malignidade endócrina, apresentando incidência aumentada nos últimos anos. O diagnóstico de rotina pode apresentar resultados inconclusivos, levando à necessidade de utilização de técnicas adicionais mais precisas, tais como a análise molecular. Portanto, é essencial a busca de marcadores moleculares para o diagnóstico dessas neoplasias e seus diferentes tipos histológicos. O objetivo deste estudo foi identificar marcadores moleculares diagnósticos para carcinoma papilífero de tireoide (CPT) e lesões de bócio. Para isso, a expressão de genes pertencentes à via MAPK/KNASE foi avaliada pela técnica de RT-qPCR. Adicionalmente, perfis bioquímicos completos das amostras foram obtidos por meio da espectroscopia de infravermelho com transformada de Fourier (FTIR). Os resultados do RT-qPCR sugerem que os genes FOS, JUN, MAP2K6, CCNA1, SFN têm o potencial de serem marcadores tumorais de lesões da tireoide, e os genes MAP2K6, CCNA1, SFN têm ainda o potencial de distinguir amostras de CPT de outras lesões de tireoide. Os resultados do FTIR mostraram que as lesões de CPT podem ser diferenciadas de tecidos normais e benignos com 95,83% de eficiência; sendo as alterações nos ácidos nucleicos o principal fator de classificação. No geral, os resultados sugerem o potencial da análise molecular e do FTIR no diagnóstico do câncer de tireoide.

Published
2022

78. RETRACTED: Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?

Author

Ventura Fernandes, Bianca H., Feitosa, Natália Martins, Barbosa, Ana Paula, Bomfim, Camila Gasque, Garnique, Anali M.B., Rosa, Ivana F., Rodrigues, Maira S., Doretto, Lucas B., Costa, Daniel F., Camargo-dos-Santos, Bruno, Franco, Gabrielli A., Neto, João Favero, Lunardi, Juliana Sartori, Bellot, Marina Sanson, Alves, Nina Pacheco Capelini, Costa, Camila C., Aracati, Mayumi F., Rodrigues, Letícia F., Cirilo, Rafaela Hemily, Colagrande, Raul Marcelino, Gomes, Francisco I.F., Nakajima, Rafael T., Belo, Marco A.A., Giaquinto, Percília Cardoso, de Oliveira, Susana Luporini, Eto, Silas Fernandes, Fernandes, Dayanne Carla, Manrique, Wilson G., Conde, Gabriel, Rosales, Roberta R.C., Todeschini, Iris, Rivero, Ilo, Llontop, Edgar, Sgro, Germán G., Oka, Gabriel Umaji, Bueno, Natalia Fernanda, Ferraris, Fausto K., de Magalhães, Mariana T.Q., Medeiros, Renata J., Mendonça-Gomes, Juliana M., Junqueira, Mara Souza, Conceição, Kátia, Pontes, Leticia Gomes de, Condino-Neto, Antonio, Perez, Andrea C., Barcellos, Leonardo J.G., Júnior, José Dias Correa, Dorlass, Erick Gustavo, Camara, Niels O.S., Durigon, Edison Luiz, Cunha, Fernando Q., Nóbrega, Rafael H., Machado-Santelli, Glaucia M., Farah, Chuck S., Veras, Flavio P., Galindo-Villegas, Jorge, Costa-Lotufo, Letícia V., Cunha, Thiago M., Chammas, Roger, Carvalho, Luciani R., Guzzo, Cristiane R., Malafaia, Guilherme, and Charlie-Silva, Ives

Published
2022
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79. Phomactinine, the First Nitrogen-Bearing Phomactin, Produced by Biatriosporasp. CBMAI 1333

Author

da Silva Oliveira, Leandro, Crnkovic, Camila M., de Amorim, Marcelo R., Navarro-Vázquez, Armando, Paz, Tiago A., Freire, Vitor F., Takaki, Mirelle, Venâncio, Tiago, Ferreira, Antonio G., de Freitas Saito, Renata, Chammas, Roger, and Berlinck, Roberto G. S.

Abstract

Metabolomics analyses and improvement of growth conditions were applied toward diversification of phomactin terpenoids by the fungus Biatriosporasp. CBMAI 1333. Visualization of molecular networking results on Gephi assisted the observation of phomactin diversification and guided the isolation of new phomactin variants by applying a modified version of chemometrics based on a fractional factorial design. Consequentially, the first nitrogen-bearing phomactin, phomactinine (1), with a new rearranged carbon skeleton, was isolated and identified. The strategy combining metabolomics and chemometrics can be extended to include bioassay potency, structure novelty, and metabolic diversification connected or not to genomic analyses.

Published
2023
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82. Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?

Author

Ventura Fernandes, Bianca H., primary, Feitosa, Natália Martins, additional, Barbosa, Ana Paula, additional, Bomfim, Camila Gasque, additional, Garnique, Anali M.B., additional, Rosa, Ivana F., additional, Rodrigues, Maira S., additional, Doretto, Lucas B., additional, Costa, Daniel F., additional, Camargo-dos-Santos, Bruno, additional, Franco, Gabrielli A., additional, Neto, João Favero, additional, Lunardi, Juliana Sartori, additional, Bellot, Marina Sanson, additional, Alves, Nina Pacheco Capelini, additional, Costa, Camila C., additional, Aracati, Mayumi F., additional, Rodrigues, Letícia F., additional, Cirilo, Rafaela Hemily, additional, Colagrande, Raul Marcelino, additional, Gomes, Francisco I.F., additional, Nakajima, Rafael T., additional, Belo, Marco A.A., additional, Giaquinto, Percília Cardoso, additional, de Oliveira, Susana Luporini, additional, Eto, Silas Fernandes, additional, Fernandes, Dayanne Carla, additional, Manrique, Wilson G., additional, Conde, Gabriel, additional, Rosales, Roberta R.C., additional, Todeschini, Iris, additional, Rivero, Ilo, additional, Llontop, Edgar, additional, Sgro, Germán G., additional, Oka, Gabriel Umaji, additional, Bueno, Natalia Fernanda, additional, Ferraris, Fausto K., additional, de Magalhães, Mariana T.Q., additional, Medeiros, Renata J., additional, Mendonça-Gomes, Juliana M., additional, Junqueira, Mara Souza, additional, Conceição, Kátia, additional, Pontes, Leticia Gomes de, additional, Condino-Neto, Antonio, additional, Perez, Andrea C., additional, Barcellos, Leonardo J.G., additional, Júnior, José Dias Correa, additional, Dorlass, Erick Gustavo, additional, Camara, Niels O.S., additional, Durigon, Edison Luiz, additional, Cunha, Fernando Q., additional, Nóbrega, Rafael H., additional, Machado-Santelli, Glaucia M., additional, Farah, Chuck S., additional, Veras, Flavio P., additional, Galindo-Villegas, Jorge, additional, Costa-Lotufo, Letícia V., additional, Cunha, Thiago M., additional, Chammas, Roger, additional, Carvalho, Luciani R., additional, Guzzo, Cristiane R., additional, Malafaia, Guilherme, additional, and Charlie-Silva, Ives, additional

Published
2022
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84. An international, interlaboratory ring trial confirms the feasibility of an extraction-less “direct” RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples

Author

Mills, Margaret G., primary, Bruce, Emily, additional, Huang, Meei-Li, additional, Crothers, Jessica W., additional, Hyrien, Ollivier, additional, Oura, Christopher A. L., additional, Blake, Lemar, additional, Brown Jordan, Arianne, additional, Hester, Susan, additional, Wehmas, Leah, additional, Mari, Bernard, additional, Barby, Pascal, additional, Lacoux, Caroline, additional, Fassy, Julien, additional, Vial, Pablo, additional, Vial, Cecilia, additional, Martinez, Jose R. W., additional, Oladipo, Olusola Olalekan, additional, Inuwa, Bitrus, additional, Shittu, Ismaila, additional, Meseko, Clement A., additional, Chammas, Roger, additional, Santos, Carlos Ferreira, additional, Dionísio, Thiago José, additional, Garbieri, Thais Francini, additional, Parisi, Viviane Aparecida, additional, Mendes-Correa, Maria Cassia, additional, de Paula, Anderson V., additional, Romano, Camila M., additional, Góes, Luiz Gustavo Bentim, additional, Minoprio, Paola, additional, Campos, Angelica C., additional, Cunha, Marielton P., additional, Vilela, Ana Paula P., additional, Nyirenda, Tonney, additional, Mkakosya, Rajhab Sawasawa, additional, Muula, Adamson S., additional, Dumm, Rebekah E., additional, Harris, Rebecca M., additional, Mitchell, Constance A., additional, Pettit, Syril, additional, Botten, Jason, additional, and Jerome, Keith R., additional

Published
2022
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88. A gene expression profile related to immune dampening in the tumor microenvironment is associated with poor prognosis in gastric adenocarcinoma

Author

Pasini, Fatima Solange, Zilberstein, Bruno, Snitcovsky, Igor, Roela, Rosimeire Aparecida, Mangone, Flavia R. Rotea, Ribeiro, Jr., Ulysses, Nonogaki, Suely, Brito, Glauber Costa, Callegari, Giovanna D., Cecconello, Ivan, Alves, Venancio Avancini Ferreira, Eluf-Neto, José, Chammas, Roger, and Federico, Miriam Hatsue Honda

Published
2014
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92. Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk

Author

Lu, Ye, primary, Gentiluomo, Manuel, additional, Macauda, Angelica, additional, Gioffreda, Domenica, additional, Gazouli, Maria, additional, Petrone, Maria C., additional, Kelemen, Dezső, additional, Ginocchi, Laura, additional, Morelli, Luca, additional, Papiris, Konstantinos, additional, Greenhalf, William, additional, Izbicki, Jakob R., additional, Kiudelis, Vytautas, additional, Mohelníková-Duchoňová, Beatrice, additional, Bueno-de-Mesquita, Bas, additional, Vodicka, Pavel, additional, Brenner, Hermann, additional, Diener, Markus K., additional, Pezzilli, Raffaele, additional, Ivanauskas, Audrius, additional, Salvia, Roberto, additional, Szentesi, Andrea, additional, Aoki, Mateus Nóbrega, additional, Németh, Balázs C., additional, Sperti, Cosimo, additional, Jamroziak, Krzysztof, additional, Chammas, Roger, additional, Oliverius, Martin, additional, Archibugi, Livia, additional, Ermini, Stefano, additional, Novák, János, additional, Kupcinskas, Juozas, additional, Strouhal, Ondřej, additional, Souček, Pavel, additional, Cavestro, Giulia M., additional, Milanetto, Anna C., additional, Vanella, Giuseppe, additional, Neoptolemos, John P., additional, Theodoropoulos, George E., additional, van Laarhoven, Hanneke W. M., additional, Mambrini, Andrea, additional, Moz, Stefania, additional, Kala, Zdenek, additional, Loveček, Martin, additional, Basso, Daniela, additional, Uzunoglu, Faik G., additional, Hackert, Thilo, additional, Testoni, Sabrina G. G., additional, Hlaváč, Viktor, additional, Andriulli, Angelo, additional, Lucchesi, Maurizio, additional, Tavano, Francesca, additional, Carrara, Silvia, additional, Hegyi, Péter, additional, Arcidiacono, Paolo G., additional, Busch, Olivier R., additional, Lawlor, Rita T., additional, Puzzono, Marta, additional, Boggi, Ugo, additional, Guo, Feng, additional, Małecka-Panas, Ewa, additional, Capurso, Gabriele, additional, Landi, Stefano, additional, Talar-Wojnarowska, Renata, additional, Strobel, Oliver, additional, Gao, Xin, additional, Vashist, Yogesh, additional, Campa, Daniele, additional, and Canzian, Federico, additional

Published
2021
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95. The International Society of RNA Nanotechnology and Nanomedicine (ISRNN): The Present and Future of the Burgeoning Field

Author

Chandler, Morgan, primary, Johnson, Brittany, additional, Khisamutdinov, Emil, additional, Dobrovolskaia, Marina A., additional, Sztuba-Solinska, Joanna, additional, Salem, Aliasger K., additional, Breyne, Koen, additional, Chammas, Roger, additional, Walter, Nils G., additional, Contreras, Lydia M., additional, Guo, Peixuan, additional, and Afonin, Kirill A., additional

Published
2021
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99. Potential of [ 11 C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model.

Author

de Souza, Aline Morais, Real, Caroline Cristiano, Junqueira, Mara de Souza, Estessi de Souza, Larissa, Navarro Marques, Fábio Luiz, Buchpiguel, Carlos Alberto, Chammas, Roger, Sapienza, Marcelo Tatit, and de Paula Faria, Daniele

Subjects
POSITRON emission tomography, BREAST tumors, AUTORADIOGRAPHY
Abstract

Background: Breast tumor inflammation is an immunological process that occurs mainly by mediation of Tumor-Associated Macrophages (TAM). Aiming for a specific measurement of tumor inflammation, the current study evaluated the potential of Positron Emission Tomography (PET) imaging with [11C](R)-PK11195 to evaluate tumor inflammation in a mammary tumor animal model. Methods: Female Balb/C mice were inoculated with 4T1 cells. The PET imaging with [11C](R)-PK11195 and [18F]FDG was acquired 3 days, 1 week, and 2 weeks after cell inoculation. Results: The [11C](R)-PK11195 tumor uptake increased from 3 days to 1 week, and decreased at 2 weeks after cell inoculation, as opposed to the [18F]FDG uptake, which showed a slight decrease in uptake at 1 week and increased uptake at 2 weeks. In the control group, no significant differences occurred in tracer uptake over time. Tumor uptake of both radiopharmaceuticals is more expressed in tumor edge regions, with greater intensity at 2 weeks, as demonstrated by [11C](R)-PK11195 autoradiography and immunofluorescence with TSPO antibodies and CD86 pro-inflammatory phenotype. Conclusion: The [11C](R)-PK11195 was able to identify heterogeneous tumor inflammation in a murine model of breast cancer and the uptake varied according to tumor size. Together with the glycolytic marker [18F]FDG, molecular imaging with [11C](R)-PK11195 may provide a better characterization of inflammatory responses in cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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