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796 results on '"Cata, Juan P."'

61. Race, Ethnicity, and Sustained Opioid Use After Major Abdominal Surgery for Cancer.

Author

Owusu-Agyemang, Pascal, Feng, Lei, and Cata, Juan P

Subjects
RACE, ABDOMINAL surgery, ETHNICITY, ONCOLOGIC surgery, OPIOIDS
Abstract

Objective was to determine whether there is any association between a patient's race or ethnicity and the sustained use of opioids in the year following surgery. Opioid use over the initial 3, 6, and 12 postoperative months was categorized as "sustained early", persistent, and chronic, respectively.Patients and Methods: Single-institution retrospective study of adults (≥ 18 years) who had undergone open abdominal surgery for cancer. Multivariable logistic regression was used to evaluate the association between race/ethnicity and opioid use.Results: Of the 3523 patients included in the study, 2543 (72.2%) were non-Hispanic (NH) White, 476 (13.5%) were Hispanic or Latino, 262 (7.4%) were NH-Black, 186 (5.3%) were Asian, and 56 (1.6%) belonged to other racial or ethnic groups. The overall rates of sustained early, persistent, and chronic opioid use were 15.9%, 7.1%, and 2.6%, respectively. In the multivariable analysis, patient race/ethnicity was associated with sustained early postoperative opioid use (p-value=0.037), with Hispanics/Latinos having significantly higher odds than NH-Whites (OR = 1.382 [95% CI: 1.057– 1.808]; p = 0.018). However, neither persistent nor chronic opioid use was associated with race/ethnicity (p = 0.697 and p = 0.443, respectively).Conclusion: In this retrospective study of adults who had undergone open abdominal surgery, patient race/ethnicity was not consistently associated with the development of sustained opioid use over the first 12 postoperative months. [ABSTRACT FROM AUTHOR]

Published
2023
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65. MNK inhibitor eFT508 (Tomivosertib) suppresses ectopic activity in human dorsal root ganglion neurons from dermatomes with radicular neuropathic pain

Author

Li, Yan, Uhelski, Megan L., North, Robert Y., Mwirigi, Juliet M., Tatsui, Claudio E., Cata, Juan P., Corrales, German, Price, Theodore J., and Dougherty, Patrick M.

Subjects
Article
Abstract

Spontaneous activity in dorsal root ganglion (DRG) neurons is a key driver of neuropathic pain in preclinical models and in patients suffering from this largely untreated disease. While many intracellular signaling mechanisms have been examined in preclinical models that drive this spontaneous activity (SA), none of these have been tested directly on spontaneously active human nociceptors. Using cultured DRG neurons recovered during thoracic vertebrectomy surgeries, we show that inhibition of mitogen activated protein kinase interacting kinase (MNK) with eFT508 (25 nM) reverses SA in human sensory neurons associated with painful dermatomes. MNK inhibition in spontaneously active nociceptors decreased action potential amplitude and produced alterations in the magnitude of afterhyperpolarizing currents suggesting modification of Na (+) and K (+) channel activity downstream of MNK inhibition. The effects of MNK inhibition on SA took minutes to emerge and were reversible over time with eFT508 washout. MNK inhibition with eFT508 led to a profound loss of eIF4E Serine 209 phosphorylation, a specific target of the kinase, within 2 min of drug treatment, consistent with the rapid action of the drug on SA in electrophysiology experiments. Our results create a compelling case for the future testing of MNK inhibitors in clinical trials for neuropathic pain. CONFLICT OF INTEREST: TJP is a co-founder of 4E Therapeutics, a company developing MNK inhibitors for neuropathic pain. The other authors declare no conflicts of interest.

Published
2023

72. Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial

Author

Conen, David, primary, Popova, Ekaterine, additional, Wang, Michael Ke, additional, Chan, Matthew T.V., additional, Landoni, Giovanni, additional, Reimer, Cara, additional, Srinathan, Sadeesh K., additional, Cata, Juan P., additional, McLean, Sean R., additional, Reyes, Juan Carlos Trujillo, additional, Grande, Ascensión Martín, additional, Tallada, Anna Gonzalez, additional, Sessler, Daniel I., additional, Fleischmann, Edith, additional, Maziak, Donna E., additional, Kabon, Barbara, additional, Voltolini, Luca, additional, Gutiérrez-Soriano, Laura, additional, Tandon, Vikas, additional, DuMerton, Deborah, additional, Kidane, Biniam, additional, Rajaram, Ravi, additional, Shargall, Yaron, additional, Neary, John D., additional, Wells, Jennifer R., additional, McIntyre, William F., additional, Blum, Steffen, additional, Ofori, Sandra N., additional, Vincent, Jessica, additional, Xu, Lizhen, additional, Li, Zhuoru, additional, Healey, Jeff S., additional, Garg, Amit X., additional, and Devereaux, PJ, additional

Published
2023
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86. Developing Expert International Consensus Statements for Opioid-Sparing Analgesia Using the Delphi Method

Author

Der, Daniel Sng Da, primary, Uitenbosch, Giulia, additional, de Boer, Hans D., additional, Carvalho, Hugo Nogueira, additional, Cata, Juan P, additional, Erdoes, Gabor, additional, Heytens, Luc, additional, Lois, Fernande Jane, additional, Pelosi, Paolo, additional, Rousseau, Anne-Françoise, additional, Forget, Patrice, additional, and Nesvadba, David, additional

Published
2022
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96. Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery

Author

Graham, Michelle M., Sessler, Daniel I., Parlow, Joel L., Biccard, Bruce M., Guyatt, Gordon, Leslie, Kate, Chan, Matthew T.V., Meyhoff, Christian S., Xavier, Denis, Sigamani, Alben, Kumar, Priya A., Mrkobrada, Marko, Cook, Deborah J., Tandon, Vikas, Alvarez-Garcia, Jesus, Villar, Juan Carlos, Painter, Thomas W., Landoni, Giovanni, Fleischmann, Edith, Lamy, Andre, Whitlock, Richard, Le Manach, Yannick, Aphang-Lam, Meylin, Cata, Juan P., Gao, Peggy, Terblanche, Nicolaas C.S., Ramana, Pamidimukkala V., Jamieson, Kim A., Bessissow, Amal, Mendoza, Gabriela R., Ramirez, Silvia, Diemunsch, Pierre A., Yusuf, Salim, and Devereaux, P.J.

Published
2018
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