304 results on '"Carrera, Sergio"'
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52. A Short Sighted and One Side Deal: Why The EU-Turkey Statement Should Never Serve As a Blueprint
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Ineli-Ciger, Meltem, Ulusoy, Orcun, Carrera, Sergio, Geddes, Andrew, Migration Law, and Kooijmans Institute
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- 2021
53. The changing landscape of European liberty and security: the mid-term report of the CHALLENGE project
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Bigo, Didier, Carrera, Sergio, Guild, Elspeth, and Walker, R.B.J.
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Social sciences - Abstract
To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1468-2451.2009.00699.x Byline: Didier Bigo (1), Sergio Carrera (2), Elspeth Guild (3), R.B.J. Walker (4) Abstract: The article offers a critical assessment of the liberties of citizens and others living in the EU and the way in which they are affected by the proliferation of discourses about insecurity, and government and transnational agencies practices of reassurance, protection and coercion enacted in the name of the safety of citizen or their collective security, in which information about their identity is exchanged through new techniques of surveillance and control. It analyses first the apparent radicalisationisation of specific forms of transnational political violence and its effects on liberal policies. Next it assesses the threat assessments produced through technologies of risk management and the development of new technologies of surveillance. Third it describes the changing forms taken by the logic of suspicion and practices of exception and derogation, especially in relation to established understandings of the rule of law, to the multidimensional and continuous reframing of the enemy. It then discusses the impact of this on the rights and freedoms of citizens and foreigners, and finally it assesses the relation between the internal and external impact of illiberal practices, especially in the context of transatlantic relations but also of an increasingly interconnected world order, and the place of the EU in this world. Author Affiliation: (1)Sciences-Po, the Institut d'Etudes Politiques de Paris (2)Centre for European Policy Studies in Brussels (3)Radboud University of Nijmegen (The Netherlands) (4)School of Politics, International Relations and Philosophy (SPIRE), Keele University more...
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- 2008
54. Reinstatement of Border control in the Schengen Area: Conflict, Symbolism and institutional Dynamics
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Cornelisse, G.N., Carrera, Sergio, Curtin, Deirdre, Geddes, Andrew, Public International Law, Kooijmans Institute, and Boundaries of Law
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SDG 16 - Peace, Justice and Strong Institutions ,Governance for Society ,Schengen, EU recht, binnengrenzen - Abstract
This chapter reflects on the significance of the absence of internal border control for the EU, highlighting its character as simultaneously highly symbolical and deeply functional. I argue that placing too much emphasis on its symbolic dimension, as is often done by the Parliament and the Commission, obscures from sight the changing connotations of territorial borders and border control in contemporary Europe, and has the unintended effect of over-privileging economic interests to the detriment of the protection of those individuals that are mostly affected by changing ‘border practices'. more...
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- 2020
55. The EU pact on migration and asylum in light of the United Nations global compact on refugees
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CARRERA, Sergio, GEDDES, Andrew, CARRERA, Sergio, and GEDDES, Andrew
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This book examines the EU Pact on Migration and Asylum from different multidisciplinary perspectives and world regions experiences. The various Chapter contributions explore the Pact's scope and impacts in light of the commitments enshrined in the United Nations Global Compact on Refugees and their compatibility with international and regional refugee law standards and EU Treaty principles. The book studies the mobility and containment components of asylum and migration management instruments and their implementing actors - in Europe and other selected world regions, as well as their inclusionary and exclusionary effects on individuals' human rights and refugee protection. more...
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- 2021
56. The European Commission’s legislative proposals in the New Pact on Migration and Asylum: Study requested by the LIBE Committee, European Parliament
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Staatsrecht, Brouwer, Evelien, Campesi, Giuseppe, Carrera, Sergio, Cortinovis, Roberto, Karageorgiou, Eleni, vosyliūte, Lina, Staatsrecht, Brouwer, Evelien, Campesi, Giuseppe, Carrera, Sergio, Cortinovis, Roberto, Karageorgiou, Eleni, and vosyliūte, Lina more...
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- 2021
57. The EU Pact on Migration and Asylum in light of the United Nations global compact on refugees : international experiences on containment and mobility and their impacts on trust and rights
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Carrera, Sergio;Geddes, Andrew and Carrera, Sergio;Geddes, Andrew
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- 2021
58. Hereditary pancreatic cancer: related syndromes and clinical perspective
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Carrera, Sergio, Sancho, Aintzane, Azkona, Eider, Azkuna, Josune, and Lopez-Vivanco, Guillermo
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Analysis ,Research ,Genetic aspects ,Prognosis ,Risk factors ,Genetic testing -- Health aspects -- Analysis ,Pancreatic cancer -- Genetic aspects -- Prognosis -- Risk factors ,Gene mutation -- Research ,Gene mutations -- Research ,Genetic screening -- Health aspects -- Analysis - Abstract
Author(s): Sergio Carrera[sup.1] , Aintzane Sancho[sup.2] , Eider Azkona[sup.2] , Josune Azkuna[sup.2] and Guillermo Lopez-Vivanco[sup.2] Background From a histological point of view [1], almost 95% of pancreatic cancers are pancreatic [...] more...
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- 2017
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59. The potential of civil society and human rights organizations through third-party interventions before the European Courts: the EU’s area of freedom, security and justice
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Carrera, Sergio, primary and Petkova, Bilyana, additional
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- 2013
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60. Optofluidic grating with optically active medium
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Calixto-Carrera, Sergio, primary, Garcia-Cordero, Jose-Luis, additional, Cedillo, Diana, additional, Naydenova, Izabela, additional, and Garnica, Guillermo, additional
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- 2021
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61. Optofluidic gratings used in refractometers
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Calixto-Carrera, Sergio, primary, Piazza, Valeria, additional, Gonzales-Suarez, Alan M., additional, Garcia-Cordero, Jose l., additional, Bruce, Neil, additional, Rosete-Aguilar, Martha, additional, and Garnica, Guillermo, additional more...
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- 2020
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62. The Strasbourg court judgement 'N.D. and N.T. v Spain' : a 'carte blanche' to push backs at EU external borders?
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CARRERA, Sergio
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Prohibition against collective expulsions ,Right to asylum ,Hot returns ,Non-refoulement ,Border fences - Abstract
This Paper examines the 'N.D. and N.T v Spain' judgment by the European Court of Human Rights (EtCHR) of 13 February 2020. The Grand Chamber of the Strasbourg Court concluded that expedited expulsions to Morocco (pushbacks or ‘hot returns’) by Spanish authorities at the border fences in Melilla did not amount to a violation of the prohibition of collective expulsions under Article 4 Protocol 4 of the European Convention of Human Rights (ECHR). Counterintuitively, the Court’s ruling is not a carte blanche for states to engage in automatic expulsions or push backs of irregular immigrants and asylum seekers at EU external borders. The Grand Chamber has confirmed that the notion of expulsion for ECHR purposes covers non-admission border management policies, and it applies to every individual irrespective of seeking asylum or not. It has also held that governments must not instrumentally frame certain parts of their territory through law as ‘non-territory’ to escape from their ECHR obligations in the context of border policies. The Grand Chamber has also demanded that States provide genuine and effective access to legal entry mechanisms for purposes of asylum and employment. The N.D. and N.T v Spain judgement is, however, fraught with legal inconsistencies and factual inaccuracies. It denies justice to voiceless victims of human rights violations. The ruling’s inconsistent legal argumentation leaves crucial nuances to avoid arbitrariness and rule of law violations in states’ border policies. By focusing on the individuals’ own conduct instead of the Spanish authorities’ compliance with the ECHR, the judgement displaces the individual from the heart towards the periphery of the ECHR system. It wrongly applies an ‘own conduct doctrine’ to human rights which are absolute in nature and accept no exception. The judges’ arguments are also factually wrong, chiefly in respect of the practical accessibility by the applicants to legal channels for admission to Spain. The Grand Chamber’s choice to first assess whether the individual is worthy of human rights contradicts Article 1 ECHR and the Strasbourg Court mandate to impartially and independently supervise States parties’ compliance with everyone’s human rights within their jurisdiction. The ruling provides an inequivalent level of human rights calling for lower protection standards in contradiction to those required by United Nations human rights bodies. It is also incompatible with the Spanish government’s obligations under EU law to comply with human rights in border control and surveillance policies, and the fundamental right to asylum. more...
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- 2020
63. Progress and Obstacles in the Area of Justice and Home Affairs in an Enlarging Europe: An Overview
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Apap, Joanna, primary and Carrera, Sergio, additional
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- 2004
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64. Fundamental rights challenges in border controls and expulsion of irregular immigrants in the European Union
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CARRERA, Sergio, STEFAN, Marco, CARRERA, Sergio, and STEFAN, Marco
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This edited volume examines the extent to which the various authorities and actors currently performing border management and expulsion-related tasks are subject to accountability mechanisms capable of delivering effective remedies and justice for abuses suffered by migrants and asylum seekers. Member states of the European Union and State Parties to the Council of Europe are under the obligation to establish complaint mechanisms allowing immigrants and/or asylum seekers to seek effective remedies in cases where their rights are violated. This book sheds light on the complaint bodies and procedures existing and available in Austria, Greece, Hungary, Italy, Spain, Poland, and Romania. It assesses their role in overseeing, investigating, and redressing cases of human rights violations deriving from violent border and immigration management practices, and expedited expulsion procedures. This book therefore provides an assessment of the practical, legal, and procedural challenges that affect the possibility to lodge complaints and access remedies for human rights violations suffered at the hands of the law enforcement authorities and other security actors operating at land, air, and sea borders, or participating in expulsions procedures – in particular, joint return flights. more...
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- 2020
65. 20 years anniversary of the Tampere Programme : Europeanisation dynamics of the EU area of freedom, security and justice
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CARRERA, Sergio, CURTIN, Deirdre, GEDDES, Andrew, CARRERA, Sergio, CURTIN, Deirdre, and GEDDES, Andrew
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This Book examines and takes stock of the main policy and legislative developments during the last 20 years of European Union cooperation on Area of Freedom, Security and Justice (AFSJ) policies. The end of 2019 coincided with the anniversary of the Tampere European Council Conclusions of October 1999, which set for the first time in European integration a common policy programme on Justice and Home Affairs (The Tampere Programme). It also corresponded with the 10 year anniversary of the Lisbon Treaty which brought a majority of these policies under the Community method of cooperation and enshrined a legally binding EU Charter of Fundamental Rights. The first set of Chapters examine the main institutional and political developments (the ‘Lisbonisation’) of AFSJ policies. They study the impacts of politicization and ‘depoliticiation’ dynamics and ‘crises’ in policy-shaping and policy making in these domains. The following Chapters cover AFSJ-thematic areas, including those related to borders and asylum, regular and irregular migration, judicial cooperation in criminal matters and police cooperation. The contributors review the current facets and latest steps in each of these AFSJ domains. They critically assess the main achievements, unfinished components, as well as the new and old challenges, paying particular attention to different types of ‘Europeanization’ dynamics (narratives, actors and instruments) witnessed during the last 20 years, their novelty or continuation, and their relations to EU rule of law, democratic and fundamental rights principles. more...
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- 2020
66. Targeted surveillance: can privacy and surveillance be reconciled?
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Carrera, Sergio, Curtin, Deirdre, Geddes, Andrew, Celeste, Edoardo, Fabbrini, Federico, Carrera, Sergio, Curtin, Deirdre, Geddes, Andrew, Celeste, Edoardo, and Fabbrini, Federico
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Striking the balance between the protection of fundamental rights and the need to protect national security has been a challenge for all liberal democracies in times of emergency. Te same is true also for the European Union (EU). In fact, since the launch 20 years ago of the 1999 Tampere programme, implementing the 1997 Treaty of Amsterdam, the EU has developed a common policy in the area of Freedom, Security and Justice (AFSJ), which led to the adoption of important pieces of legislation also concerning the fght against crime and international terrorism. At the same time, however, since 2000, the EU has been endowed with an advanced and comprehensive Charter of Fundamental Rights, which was given full primary law status by the 2009 Treaty of Lisbon. more...
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- 2020
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67. Extravasation of Docetaxel: A Red Hand Syndrome
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Barceló, Ramón, Viteri, Ainhoa, Muñoz, Alberto, Carrera, Sergio, Rubio, Itziar, and López-Vivanco, Guillermo
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- 2005
68. Policing humanitarianism : EU policies against human smuggling and their impact on civil society
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CARRERA, Sergio, MITSILEGAS, Valsamis, ALLSOPP, Jennifer, and VOSYLIUTE, Lina
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Policing Humanitarianism examines the ways in which European Union policies aimed at countering the phenomenon of migrant smuggling affect civil society actors' activities in the provision of humanitarian assistance, access to rights for irregular immigrants and asylum seekers. It explores the effects of EU policies, laws and agencies' operations in anti-migrant smuggling actions and their implementation in the following EU Member States: Italy, Greece, Hungary and the UK. The book critically studies policies designed and implemented since 2015, during the so-called 'European refugee humanitarian crisis'. 1. Introduction PART I: COUNTERING MIGRANT-SMUGGLING: EU POLICIES AND ACTORS 2. Countering Migrant-Smuggling: The EU's Policy Approach 3. The Role of EU Agencies in Countering Migrant-Smuggling PART II: THE IMPACTS OF ANTI-MIGRANTSMUGGLING POLICIES ON CIVIL SOCIETY 4. Anti-Smuggling in National Law and Perceptions among Civil Society Actors 5. Effects of Countering Facilitation of Entry on Civil Society Actors Involved at External EU Sea and Land Borders 6. Humanitarian Assistance in the Context of the EU Hotspots Approach 7. The Effects of Countering Facilitation of Residence: Access to Services and Rights PART III: CONCEPTUALISING THE EFFECTS OF EU ANTI-MIGRANT-SMUGGLING POLICIES ON CIVIL SOCIETY 8. The Three Faces of Policing the Mobility Society in the EU 9. Conclusions more...
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- 2019
69. Human rights aspects of immigrant and refugee integration policies : a comparative assessment in selected Council of Europe member states
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CARRERA, Sergio and VANKOVA, Zvezda
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This Issue Paper examines integration policies regarding immigrants and refugees in selected Council of Europe member states in light of human rights standards. In particular, it focuses on how the enjoyment of the right to respect for private and family life and the security of residence of immigrants and refugees facilitate and improve integration policies. It covers the adverse effects that mandatory language and civic integration policies and some other conditions such as income thresholds, housing requirements and reduced financial benefits might have on the socio-economic inclusion of immigrants and refugees. While taking stock of integration policies in some of the European countries which experienced unprecedented massive arrivals of migrants and refugees in the last five years the Issue Paper offers a comparative basis for identifying good integration practices. more...
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- 2019
70. The cost of non-Europe in the area of legal migration
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CARRERA, Sergio, VOSYLIUTE, Lina, VANKOVA, Zvezda, LAURENTSYEVA, Nadzeya, FERNANDES, Meena, DENNISON, James, and GUERIN, Julia
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This Research Paper is a contribution to a wider cost-of non-Europe assessment in the Area of Freedom Security and Justice requested by the European Parliament’s Committee on Civil Liberties that can be found here. The research takes stock of the state of play in European Union cooperation in the area of legal immigration. The Research Paper identifies gaps and barriers of current sectorial and fragmented EU legal immigration acquis. It assesses their economic impacts and impacts at individual level in terms of fundamental rights protection and non-discrimination laid down in international, regional and EU human rights and labour standards. The research highlights the need for ‘more EU’ in upholding equal treatment standards between third country workers with EU nationals in relation to working and living conditions. The Research Paper elaborates on the potential benefits, cost drivers and feasibility of different policy options for the EU ranging from: better enforcement, to the gradual extension of EU legislation towards other labour market sectors or bringing back to the idea of a Binding Immigration Code. The research concludes that EU internal market, national administrations as well as EU and Third Country Citizens would benefit from more homogenous policy approach in the area of legal migration. more...
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- 2019
71. The EU-Turkey statement: legal nature and compatibility with EU institutional law
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Ott, Andrea, Carrera, Sergio, Santos Vara, Juan, Strik, Tineke, International and European Law, RS: FdR - CERiM, RS: FdR Institute MCEL, RS: FdR IC Integratie, and RS: FdR Studio Europa Maastricht
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Law ,Political science ,Compatibility (mechanics) - Abstract
The EU-Turkey Statement of 18 March 2016 (Statement) is by now a famous but controversial instrument that aims to tackle the influx of migrants and asylum seekers into the EU. The Statement is indeed an enigmatic instrument, which cannot be effortlessly typified according to the categories of EU and international law. This chapter analyses the legal nature of the Statement and shows that there are good reasons to argue that this instrument is binding, but there are also valid arguments that support the opposite thesis. It seems clear, in any event, that the Statement has to be attributed to the EU – and not to the Member States, as the EU General Court found in the joined cases NF, NG, and NM. The rule of law is in any case difficult to uphold in face of the ambiguities of the Statement. Any judicial action against it is likely to encounter substantive or procedural difficulties, caused by the lacunae of EU Treaties regarding the procedures for the adoption of soft law instruments, the rules on locus standi of individuals and the admissibility of preliminary references. more...
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- 2019
72. The 20 years anniversary of the Tampere programme: Securitization, intergovernmentalism and informalization
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Carrera, Sergio, primary
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- 2020
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73. “Blanqueamiento sonoro”, occidentalización del bambuco en la segunda mitad del XIX
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Arias Carrera, Sergio Daniel, primary
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- 2020
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74. The Strasbourg Court Judgement N.D. and N.T. v Spain. A Carte Blanche to Push Backs at EU External Borders?
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Carrera, Sergio, primary
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- 2020
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75. Molecular mechanism implicated in Pemetrexed-induced apoptosis in human melanoma cells
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Buqué Aitziber, Muhialdin Jangi, Muñoz Alberto, Calvo Begoña, Carrera Sergio, Aresti Unai, Sancho Aintzane, Rubio Itziar, and López-Vivanco Guillermo
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Pemetrexed ,MTA ,Antifolates ,DNA damage ,Apoptosis ,Melanoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Metastatic melanoma is a lethal skin cancer and its incidence is rising every year. It represents a challenge for oncologist, as the current treatment options are non-curative in the majority of cases; therefore, the effort to find and/or develop novel compounds is mandatory. Pemetrexed (Alimta®, MTA) is a multitarget antifolate that inhibits folate-dependent enzymes: thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, required for de novo synthesis of nucleotides for DNA replication. It is currently used in the treatment of mesothelioma and non-small cell lung cancer (NSCLC), and has shown clinical activity in other tumors such as breast, colorectal, bladder, cervical, gastric and pancreatic cancer. However, its effect in human melanoma has not been studied yet. Results In the current work we studied the effect of MTA on four human melanoma cell lines A375, Hs294T, HT144 and MeWo and in two NSCLC cell lines H1299 and Calu-3. We have found that MTA induces DNA damage, S-phase cell cycle arrest, and caspase- dependent and –independent apoptosis. We show that an increment of the intracellular reactive oxygen species (ROS) and p53 is required for MTA-induced cytotoxicity by utilizing N-Acetyl-L-Cysteine (NAC) to blockage of ROS and p53-defective H1299 NSCLC cell line. Pretreatment of melanoma cells with NAC significantly decreased the DNA damage, p53 up-regulation and cytotoxic effect of MTA. MTA was able to induce p53 expression leading to up-regulation of p53-dependent genes Mcl-1 and PIDD, followed by a postranscriptional regulation of Mcl-1 improving apoptosis. Conclusions We found that MTA induced DNA damage and mitochondrial-mediated apoptosis in human melanoma cells in vitro and that the associated apoptosis was both caspase-dependent and –independent and p53-mediated. Our data suggest that MTA may be of therapeutic relevance for the future treatment of human malignant melanoma. more...
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- 2012
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76. The EU’s Approach to Circular Migration in the Context of the Eastern Partnership Neighbourhood
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Vankova, Zvezda, Carrera, Sergio, den Hertog, Leonhard, Kostakopoulou, Dora, Panizzon, Marion, International and European Law, RS: FdR - CERiM, RS: FDR - MACIMIDE, RS: FdR Europees Publiekrecht, RS: FdR IC Integratie, and RS: FdR Institute MCEL more...
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Circular migration ,Human rights ,media_common.quotation_subject ,General partnership ,Political science ,Refugee law ,Regional science ,Context (language use) ,International law ,Policy analysis ,Directive ,media_common - Abstract
The concept of circular migration keeps appearing in the context of the eu labour migration policy through legal instruments such as the seasonal workers directive and the proposal for a recast of the blue card directive, as well as it has been featured in the latest mobility partnership with belarus from october 2016. These examples suggest that the eu still has some interest in promoting circular migration as a policy instrument. The question is what does this interest mean in terms of the rights of migrant workers? most of the literature so far focuses on conceptualising circular migration or analysing circular migration patterns rather than looking into implementation dynamics as part of the eu migration policy and its external dimension. This chapter aims at filling namely this gap by assessing the circularity of eu labour migration policies with regards to the eastern partnership neighbourhood and addressing the question of whether they provide rights-based outcomes for migrant workers. This is done through the prism of a framework of benchmarks based on international universal and regional human rights standards as well as policy measures that foster circularity focusing on entry and re-entry conditions, work authorisation, residence, social security coordination and entry and residence conditions for family members. This chapter is based on legal empirical research and combines legal and policy analysis with qualitative methods. more...
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- 2018
77. Making and implementing multi-actor EU external migration policy: the mobility partnerships
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Reslow, Natasja, Carrera, Sergio, den Hertog, Leonhard, Kostakopoulou, Dora, Panizzon, Marion, RS: FdR IC Integratie, RS: FDR - MACIMIDE, RS: FdR - CERiM, International and European Law, and RS: FdR Institute MCEL more...
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International relations ,Intersectionality ,Vision ,Global studies ,Human rights ,Corporate governance ,media_common.quotation_subject ,Political science ,Refugee law ,International law ,Economic system ,media_common - Abstract
This chapter offers an analysis of the eu mobility partnerships as one case in point for policy intersectionality, within the framework of the multi-level governance literature. It argues that the governance of mobility partnerships is characterized by its multi-actor nature, and focuses on the consequences of different actors’ preferences and interactions for policy-making and implementation. In particular, it emphasises the roles of the non-eu countries and member states in making and shaping eu external migration policy. Finally, the chapter analyses implementation, something which has been understudied in the literature to date. It argues that the multi-actor nature of eu external migration policy presents obstacles to implementation due to the different policy visions of the different actors, and the non-hierarchical structure which links them. more...
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- 2018
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78. The External Faces of EU External Migration Law and Policy: an Introduction
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Carrera, S., den Hertog, L., Panizzon, M., Carrera, Sergio, den Hertog, Leonhard, Kostakopoulou, Dora, Panizzon, Marion, RS: FDR - MACIMIDE, and RS: FdR IC Integratie
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Economics ,External migration ,International economics - Published
- 2018
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79. In Defence of Policy Incoherence – Illustrations from EU External Migration Policy
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den Hertog, L., Carrera, Sergio, den Hertog, Leonhard, Kostakopoulou, Dora, Panizzon, Marion, RS: FDR - MACIMIDE, and RS: FdR IC Integratie
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Politics ,Government ,Order (exchange) ,media_common.quotation_subject ,Corporate governance ,Political science ,Coherence (statistics) ,Treaty ,Democracy ,Law and economics ,Rule of law ,media_common - Abstract
The issue of eu policy coherence has attracted tremendous attention from academics and policy makers. Alongside much conceptual querying of what policy coherence means, there is a continuous lamenting of the lack of policy coherence, and the need for more is stressed. Political scientists analyse the decision-making procedures and conclude that different eu institutions, bodies and agencies do not coordinate, resulting in policy coherence. Legal scientists bemoan the incoherent eu legal order and argue for further treaty reform. This chapter takes the case of the eu (external) migration policy to show that this widespread incoherence is a normal and inevitable feature of eu governance in this field, and of any pluralistic, democratic and rule of law based system of government. Divergent interests, values, and actors can only be accommodated in policies by allowing for some degree of policy incoherence, it is thus the condition upon which eu policy making is premised. The chapter argues that the dominant preoccupation with policy coherence should be reappraised, and advances a broad notion of coherence embedded in the rule of law. more...
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- 2018
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80. Constitutionalising the external dimensions of EU migration policies in times of crisis : legality, rule of law and fundamental rights reconsidered : legality, rule of law and fundamental rights reconsidered
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CARRERA, Sergio, SANTOS VARA, Juan, STRIK, Tineke, CARRERA, Sergio, SANTOS VARA, Juan, and STRIK, Tineke
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This discerning book examines EU migration and asylum polices in times of crisis by assessing old and new patterns of cooperation in EU migration management policies in the scope of third-country cooperation. The case studies explored reveal that there has been a clear tendency and strategy to move away from or go outside the decision making rules and institutional principles enshrined in the Lisbon Treaty to advance third country cooperation on migration management. It explores the implications of and effects of the adoption of extra-Treaty instruments and patterns of cooperation in the light of EU rule of law and fundamental rights principles and standards. The book, examines the ways in which ‘the politics of migration crisis’ and their patterns of cooperation and legal/policy outcomes evidenced since 2015 affect and might even undermine EU’s legitimacy in these policy areas. Constitutionalising the External Dimensions of EU Migration Policies in Times of Crisis will be a key resource for academics and students focussing on EU Law and migration more specifically. Timely and engaging, it will also appeal to policy- makers, legal practitioners and international organisation representatives alike. more...
- Published
- 2019
81. El futuro del espacio Schengen: los acontecimientos y retos más recientes en el marco de gobernanza de Schengen desde 2016. Libertades civiles, justicia y asuntos de interior
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CEPS, Parlamento Europeo. Dirección General de Políticas Interiores de la Unión, Stefan, Marco, Chun Luk, Ngo, Vosyliūtė, Lina, and Carrera, Sergio
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Política migratoria ,Schengen Information System ,Border control ,Frontera exterior de la UE ,Derechos cívicos ,Sistema de Información Schengen ,Frontera interior de la UE ,Acuerdo de Schengen ,Migración ilegal ,Derecho a la justicia ,Information transfer ,Frontex ,Schengen Agreement ,Migration policy ,Intercambio de información ,Región fronteriza ,Frontier region ,Unión Europea ,Area of freedom, security and justice ,Illegal migration ,European Union ,Control fronterizo ,Civil rights ,Espacio de libertad, seguridad y justicia ,Right to justice - Abstract
El ISBN corresponde a la versión electrónica del documento El presente estudio evalúa los principales acontecimientos que han tenido lugar en el marco de gobernanza de Schengen desde 2016. Se examina una serie de retos que afectan actualmente al funcionamiento del espacio Schengen. En primer lugar, el presente documento analiza la legitimidad de las decisiones adoptadas por una serie de Estados Schengen de mantener controles en las fronteras interiores. En segundo lugar, se evalúan las propuestas políticas más recientes en materia de controles policiales internos a la luz de las pertinentes normas jurídicas de la Unión, entre las que se incluyen la necesidad, la proporcionalidad y la seguridad jurídica. El documento también cuestiona la eficacia y la legalidad de las murallas y vallas fronterizas erigidas recientemente en las fronteras exteriores de la Unión y dentro del espacio Schengen. Además, los autores examinan detalladamente cómo el marco de gobernanza de Schengen depende cada vez más de una Agencia Frontex reforzada operativa y estratégicamente y de la interoperabilidad gradual de diferentes sistemas de información de gran escala, como SIS II, VIS y Eurodac. El documento analiza los retos que las funciones cada vez más extensas de estas infraestructuras de gestión de fronteras e información plantean en lo relativo al respeto del Estado de Derecho y los derechos fundamentales. Se sostiene que, aunque el espacio Schengen sigue siendo resistente a las crisis, debe hacerse más a nivel nacional y de la Unión para ir más allá del actual modo de crisis en la toma de decisiones sobre migración y fronteras y avanzar hacia un Sistema Europeo de Asilo estable. more...
- Published
- 2018
82. Fit for purpose? : the Facilitation Directive and the criminalisation of humanitarian assistance to irregular migrants : 2018 update
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CARRERA, Sergio, SANCHEZ, Gabriella, VOSYLIUTE, Lina, SMIALOWSKI, Stephanie, and ALLSOPP, Jennifer
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Policing ,Migrant smuggling ,Rule of law ,Facilitation directive ,Migration - Abstract
This study, commissioned by the European Parliament’s Policy Department for Citizens’ Rights and Constitutional Affairs at the request of the PETI Committee, aims to update the 2016 study “Fit for purpose? The Facilitation Directive and the criminalisation of humanitarian assistance to irregular migrants”. It takes stock of and examines the latest developments that have taken place since 2016, specifically the legislative and policy changes, along with various forms and cases of criminalisation of humanitarian actors, migrants’ family members and basic service providers. The study uses the notion of ‘policing humanitarianism’ to describe not only cases of formal prosecution and sentencing in criminal justice procedures, but also wider dynamics of suspicion, intimidation, harassment and disciplining in five selected Member States – Belgium, France, Greece, Hungary and Italy. Policing humanitarianism negatively affects EU citizens’ rights – such as the freedom of assembly, freedom of speech and freedom of conscience. When civil society is effectively (self-)silenced and its accountability role undermined, policies to combat migrant smuggling may be overused and give rise to serious breaches of the EU’s founding values, notably the rule of law, democracy and fundamental rights. Moreover, policing humanitarianism negatively affects wider societal trust and diverts the limited resources of law enforcement from investigating more serious crimes. more...
- Published
- 2018
83. Offshoring Asylum and Migration in Australia, Spain, Tunisia and the US: Lessons learned and feasibility for the EU
- Author
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Carrera, Sergio, El Qadim, Nora, Fullerton, Maryellen, Garcés-Mascareñas, Blanca, York Kneebone, Susan, López Sala, Ana María, Chun Luk, Ngo, Vosyliuté, Lina, López Sala, Ana María, El Qadim, Nora, Garcés-Mascareñas, Blanca, Vosyliuté, Lina, López Sala, Ana María [0000-0003-2756-7042], El Qadim, Nora [0000-0001-9692-8820], Garcés-Mascareñas, Blanca [0000-0003-4039-3964], and Vosyliuté, Lina [0000-0003-3592-541X] more...
- Subjects
Borders ,Offshoring ,Spain ,Migration control ,Externalization - Abstract
This report examines the feasibility of extra-territorial processing of asylum and migration management for the EU. Based on a comparative account of past and current experiences of extra-territorialisation of asylum processing and migration policies in Australia, Spain, Tunisia, and the US, the Report draws 'lessons learned' and identifies key challenges from the perspective of their effectiveness. The findings highlight how external processing of asylum applications is politically, legally and operationally unfeasible and ineffective for the EU. It would pose profound challenges to EU and Member States' rule of law and human rights obligations. Past and current policies outsourcing protection obligations to third countries often amount to extra-legal processes as well as violations of the principle of non-refoulement and of the prohibition of arbitrary detention under inhuman and degrading conditions. The research findings show that extraterritorial actions of the EU and its Member States abroad would fall to varying degrees under EU and domestic judicial, administrative and financial accountabilities which present strong potentials for bringing portable justice to potential victims of human rights violations. In this way, this report contributes to and suggests ways forward in creative legal thinking to close any loopholes inherent to ideas on extraterritorial asylum processing and migration management for the EU., The report has been produced with the financial support of the Open Society European Policy Institute (OSEPI) more...
- Published
- 2018
84. International cooperation and the exchange of personal data: Safeguarding trust and fundamental rights
- Author
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Brouwer, E.R., Carrera, Sergio, Mitsilegas, Valsamis, Migration Law, and Kooijmans Institute
- Published
- 2017
85. Trump’s Travel Bans: Harvesting personal data and requiem for the EU-US Privacy Shield
- Author
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Bigo, Didier, Carrera, Sergio, and Guild, Elspeth
- Subjects
EU-US Privacy Shield ,European Union ,Donald Trump ,United States - Abstract
This Policy Insight examines the main implications and challenges of the recent Executive Orders or ‘travel bans’ issued by US President Donald Trump. It argues that one of the key ulterior motives behind these orders is to manoeuvre the US into an advantageous position for harvesting personal data on individuals from around the world, including EU citizens and residents. The paper analyses these orders and other recent US legislative developments that allow for greater access and processing of raw communications of EU citizens, and argues that they put the sustainability of the EU-US Privacy Shield and the EU right to privacy under profound strain. The authors call for more diplomacy and democratic rule of law with fundamental rights guarantees and cooperation, as the most effective antidote to the pervasive mistrust and legal uncertainty engendered by these Executive Orders. In any case these developments call for the European Commission to take an assertive position and suspend the EU-US Privacy Shield, as this is the only way to ensure legal certainty for companies, citizens and authorities in the EU. This would also send a clear signal to the US about the absolute need to take into account the conflicts of law challenges that these orders pose for the EU and member states' data protection legal systems. The paper also recommends re-designing and strengthening the current EU-US Transatlantic Legislators Dialogue between the European Parliament and its US counterparts to better allow for a closer consultation on relevant US and EU policies with deep repercussions on transatlantic relations and citizens across the board. more...
- Published
- 2017
86. ¿Cómo es la atención médica urgente a pacientes en seguimiento por un Equipo de Soporte Domiciliario?
- Author
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Espejo González, Ana, primary, Baeza Monedero, María Elena, additional, Albéniz López, Jana, additional, Sacristán Rodea, Antonio, additional, Galdón Planas, Gloria, additional, Collazo Carrera, Sergio, additional, and González Torrejón, Manuel, additional more...
- Published
- 2019
- Full Text
- View/download PDF
87. Interfacial Engineering of TiO2 by Graphene Nanoplatelets for High-Efficiency Hysteresis-free Perovskite Solar Cells
- Author
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Sidhik, Siraj, primary, Panikar, Sandeep Surendra, additional, Pérez, Christopher Rosiles, additional, Luke, Tzarara López, additional, Carriles, Ramón, additional, Carrera, Sergio Calixto, additional, and De la Rosa, Elder, additional more...
- Published
- 2018
- Full Text
- View/download PDF
88. EU external migration policies in an era of global mobilities : intersecting policy universes
- Author
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CARRERA, Sergio, DEN HERTOG, Leonhard, PAMOZZON, Marion, KOSTAKOPOULOU, Dora, CARRERA, Sergio, DEN HERTOG, Leonhard, PAMOZZON, Marion, and KOSTAKOPOULOU, Dora
- Abstract
This collective volume draws on the themes of intersectionality and overlapping policy universes to examine and evaluate the shifting functions, frames and multiple actors and instruments of an ongoing and revitalised cooperation in EU external migration and asylum policies with third states. The contributions are based on problem-driven research and seek to develop bottom-up, policy-oriented solutions, while taking into account global, EU-based and local perspectives, and the shifting universes of EU migration, border and asylum policies. In 15 chapters, we explore the multifaceted dimensions of the EU external migration policy and its evolution in the post-crisis, geopolitical environment of the Global Compacts. more...
- Published
- 2018
89. The EU and the Migration Crisis: reinforcing a security based approach to Migration?
- Author
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Santos Vara, Juan, Carrera, Sergio, Strik, Tineke, McArdle, Scarlett, Gomez Arana, Arantza, Santos Vara, Juan, Carrera, Sergio, Strik, Tineke, McArdle, Scarlett, and Gomez Arana, Arantza
- Abstract
This chapter makes this argument that the EU's narrow, security-based, approach does not succeed in developing a comprehensive migration policy, and neither has it addressed the human issues arising from a crisis such as that currently being seen in the Mediterranean, It does so in three parts. It, first of all, considers the longstanding security focus of the EU in relation to migration and the more recent attempt at moving towards a ‘comprehensive’ approach. It then, secondly, critiques this approach through an examination of the EU’s response through utilising crisis management operations under the EU’s Common Security and Defence Policy (CSDP), in particular the EUNAVFOR Med operation. This contribution argues that utilising military means in order to address a humanitarian question is problematic and the expansion of the EUNAVFOR Med operation in terms of its cooperation with the Libyan authorities shows a further focus on security in place of the apparent ‘comprehensive’ approach here. The existing approach shows little prospect of success and is also now giving rise to increased risk to individuals caught up in this crisis; rather than finding their way to safety, these people are finding themselves in equally dangerous situations. The chapter finally considers the continuing problems and the overall prospects for addressing these issues and developing a renewed, truly comprehensive approach. more...
- Published
- 2018
90. Offshoring Asylum and Migration in Australia, Spain, Tunisia and the US: Lessons learned and feasibility for the EU
- Author
-
López Sala, Ana María [0000-0003-2756-7042], El Qadim, Nora [0000-0001-9692-8820], Garcés-Mascareñas, Blanca [0000-0003-4039-3964], Vosyliuté, Lina [0000-0003-3592-541X], Carrera, Sergio, El Qadim, Nora, Fullerton, Maryellen, Garcés-Mascareñas, Blanca, York Kneebone, Susan, López Sala, Ana María, Chun Luk, Ngo, Vosyliuté, Lina, López Sala, Ana María [0000-0003-2756-7042], El Qadim, Nora [0000-0001-9692-8820], Garcés-Mascareñas, Blanca [0000-0003-4039-3964], Vosyliuté, Lina [0000-0003-3592-541X], Carrera, Sergio, El Qadim, Nora, Fullerton, Maryellen, Garcés-Mascareñas, Blanca, York Kneebone, Susan, López Sala, Ana María, Chun Luk, Ngo, and Vosyliuté, Lina more...
- Abstract
This report examines the feasibility of extra-territorial processing of asylum and migration management for the EU. Based on a comparative account of past and current experiences of extra-territorialisation of asylum processing and migration policies in Australia, Spain, Tunisia, and the US, the Report draws 'lessons learned' and identifies key challenges from the perspective of their effectiveness. The findings highlight how external processing of asylum applications is politically, legally and operationally unfeasible and ineffective for the EU. It would pose profound challenges to EU and Member States' rule of law and human rights obligations. Past and current policies outsourcing protection obligations to third countries often amount to extra-legal processes as well as violations of the principle of non-refoulement and of the prohibition of arbitrary detention under inhuman and degrading conditions. The research findings show that extraterritorial actions of the EU and its Member States abroad would fall to varying degrees under EU and domestic judicial, administrative and financial accountabilities which present strong potentials for bringing portable justice to potential victims of human rights violations. In this way, this report contributes to and suggests ways forward in creative legal thinking to close any loopholes inherent to ideas on extraterritorial asylum processing and migration management for the EU. more...
- Published
- 2018
91. Annex 2. Protection of linguistic minorities (A focus on speakers of autochthonous languages
- Author
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van der Velden, B.D., Carrera, Sergio, Guild, Elspeth, Vosyliūtė, Lina, Bard, Petra, RS-Research Program Law in a network society (LNS), and Department Private law
- Subjects
rights of the individual ,EU law - international law ,democracy ,legal system ,European Union countries ,Religious minorities ,protection of minorities ,human rights ,Linguistic minorities ,Ethnic relations ,Minorities - Published
- 2017
92. Mach-Zehnder interferometer applied to the study polymers relative humidity response
- Author
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Calixto-Carrera, Sergio, primary, Calixto Olalde, Maria Elena, primary, Hernandez-Barajas, Jose, primary, and Vazquez Espitia, Omar, primary
- Published
- 2018
- Full Text
- View/download PDF
93. Policing the mobility society: the effects of EU anti-migrant smuggling policies on humanitarianism
- Author
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Carrera, Sergio, primary, Allsopp, Jennifer, additional, and Vosyliūtė, Lina, additional
- Published
- 2018
- Full Text
- View/download PDF
94. EU-Morocco cooperation on readmission, borders and protection : a model to follow?
- Author
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Carrera, Sergio, Cassarino, Jean-Pierre, El Qadim, Nora, Lahlou, Mehdi, Den Hertog, Leonhard, Centre for European Policy Studies (CEPS), Center for European Polic Studies, Institut de recherche sur le maghreb contemporain (IRMC), Aix Marseille Université (AMU)-Ministère de l'Europe et des Affaires étrangères (MEAE)-Centre National de la Recherche Scientifique (CNRS), Université Paris 8 Vincennes-Saint-Denis - Département de sociologie et d’anthropologie, Université Paris 8 Vincennes-Saint-Denis (UP8), Insea, MIN AFF ETRANG-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-MIN AFF ETRANG-Centre National de la Recherche Scientifique (CNRS), and Cassarino, Jean-Pierre more...
- Subjects
[SHS.SOCIO]Humanities and Social Sciences/Sociology ,[SHS.DROIT]Humanities and Social Sciences/Law ,[SHS.DROIT] Humanities and Social Sciences/Law ,Turkey ,[SHS.SOCIO] Humanities and Social Sciences/Sociology ,Maghreb ,International relations ,Foreign policy ,[SHS.SCIPO] Humanities and Social Sciences/Political science ,Readmission ,Migration ,[SHS.SCIPO]Humanities and Social Sciences/Political science - Abstract
Published online 22 January 2016 Greater cooperation with third countries is one of the EU’s core responses to the refugee crisis. This cooperation is focused on the readmission of individuals irregularly staying in the EU, on border surveillance and control, and on the reception of refugees in third countries. The EU has attempted to co-opt Turkey and African countries into these priorities, using funding and specific mobility channels as incentives. This paper poses the question of what kind of cooperation the EU should pursue with third countries. As the current approaches are not new, we present the lessons from the EU’s long cooperation with Morocco to inform the current debate. We find that, first, the difficult negotiations on an EU Readmission Agreement with Morocco show that more funding or ‘incentives’ cannot guarantee such an agreement, let alone its implementation. Second, we highlight the challenges of the partly EU-funded and Frontex-coordinated cooperation on borders between Spain and Morocco, which hampers the capacity of third countries to respect migrants’ rights and challenges the obligations of EU member states under European and international law. Third, as EU cooperation with Turkey and Africa now aims to ‘stem’ the flow of asylum-seekers, the capacity of third countries to offer reception and protection to asylumseekers is crucial. We conclude that Morocco has limited capacities in this regard, which raises the question of whether third countries can be assumed to be able to offer such reception and protection. We argue that the lessons learnt from the cooperation with Morocco illustrate the limited feasibility and appropriateness of the EU’s approach towards third countries. Cooperation with third countries should not come at the expense of migrants’ rights, but should open up regular channels for seeking asylum, and not link readmission to other fields of EU external action under the ‘more-for-more’ principle. more...
- Published
- 2016
95. The EU and its Counter-Terrorism Policies after the Paris Attacks
- Author
-
Bigo, Didier, Carrera, Sergio, Guild, Elspeth, Guittet, Emmanuel-Pierre, Jeandesboz, Julien, Mitsilegas, Valsamis, Ragazzi, Francesco, and Scherrer, Amandine
- Abstract
This paper examines the EU’s counter-terrorism policies responding to the Paris attacks of 13 November 2015. It argues that these events call for a re-think of the current information-sharing and preventive-justice model guiding the EU’s counter-terrorism tools, along with security agencies such as Europol and Eurojust. Priority should be given to independently evaluating ‘what has worked’ and ‘what has not’ when it comes to police and criminal justice cooperation in the Union. Current EU counter-terrorism policies face two challenges: one is related to their efficiency and other concerns their legality. ‘More data’ without the necessary human resources, more effective cross-border operational cooperation and more trust between the law enforcement authorities of EU member states is not an efficient policy response. Large-scale surveillance and preventive justice techniques are also incompatible with the legal and judicial standards developed by the Court of Justice of the EU. The EU can bring further added value first, by boosting traditional policing and criminal justice cooperation to fight terrorism; second, by re-directing EU agencies’ competences towards more coordination and support in cross-border operational cooperation and joint investigations, subject to greater accountability checks (Europol and Eurojust +); and third, by improving the use of policy measures following a criminal justice-led cooperation model focused on improving cross-border joint investigations and the use of information that meets the quality standards of ‘evidence’ in criminal judicial proceedings. Any EU and national counter-terrorism policies must not undermine democratic rule of law, fundamental rights or the EU’s founding constitutional principles, such as the free movement of persons and the Schengen system. Otherwise, these policies will defeat their purpose by generating more insecurity, instability, mistrust and legal uncertainty for all. more...
- Published
- 2015
96. A quest for accountability? EU and Member State inquiries into the CIA Rendition and Secret Detention Programme
- Author
-
Bigo, Didier, Carrera, Sergio, Guild, Elspeth, and Radescu, Raluca
- Abstract
This study assesses the extent to which EU Member States have delivered accountability for their complicity in the US CIA-led extraordinary rendition and secret detention programme and its serious human rights violations. It offers a scoreboard of political inquiries and judicial investigations in supranational and national arenas in relation to Italy, Lithuania, Poland, Romania and the United Kingdom. The study takes as a starting point two recent and far-reaching developments in delivering accountability and establishing the truth: the publication of the executive summary of the US Senate Intelligence Committee (Feinstein) Report and new European Court of Human Rights judgments regarding EU Member States’ complicity with the CIA. The study identifies significant obstacles to further accountability in the five EU Member States under investigation: notably the lack of independent and effective official investigations and the use of the ‘state secrets doctrine’ to prevent disclosure of the facts, evade responsibility and hinder redress to the victims. The study puts forward a set of policy recommendations addressed to the European Parliament for removing these obstacles to effective accountability. This report was commissioned by the Civil Liberties and Justice and Home Affairs (LIBE) Committee of the European Parliament. more...
- Published
- 2015
97. Britain and the European debate on the uses of secrecy in court
- Author
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Bigo, Didier, Carrera, Sergio, Hernanz, Nicholas, and Scherrer, Amandine
- Abstract
EU scrutiny in the field of the use of closed materials in UK courts is of paramount importance for the future of democratic systems of justice, even if it polarises once more the positions for or against Brexit. more...
- Published
- 2015
98. Constitutionalising the Security Union : effectiveness, rule of law and rights in countering terrorism and crime
- Author
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CARRERA, Sergio, MITSILEGAS, Valsamis, CARRERA, Sergio, and MITSILEGAS, Valsamis
- Abstract
This collective volume offers a multidisciplinary examination of the critical issues and challenges associated with the EU's initiative to build a Security Union, particularly in relation to common policies adopted at the member state level aimed at countering terrorism and crime. It delves into the EU's efforts to support cross-border investigations, the exchange of information and international cooperation, taking stock of the effects on freedom and privacy. The various authors offer key research findings, which contributed to the European Commission's 2017 Comprehensive Assessment of EU Security Policy. They identify and explore the main constitutional dilemmas facing the Security Union concerning EU standards enshrined in the Lisbon Treaty and the commitments undertaken in the context of the EU Better Regulation agenda. Hence, this examination of EU security policies sheds light on their effectiveness, proportionality, fundamental rights and societal implications. more...
- Published
- 2017
99. Pathways towards legal migration into the EU : reappraising concepts, trajectories and policies
- Author
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CARRERA, Sergio, GEDDES, Andrew, GUILD, Elspeth, STEFAN, Marco, CARRERA, Sergio, GEDDES, Andrew, GUILD, Elspeth, and STEFAN, Marco
- Abstract
Over the past 15 years, the ‘Europeanisation’ of policies dealing with the conditions of entry and residence of third-country nationals has led to the development of a common EU acquis. Yet questions related to policy consistency, legal certainty and fair and non-discriminatory treatment in working and living standards still characterise the EU’s legal framework for cross-border mobility. This book critically explores the extent to which EU legal migration policies and their underlying working notions match the transnational mobility of individuals today. It addresses the main challenges of economic migration policies, both within the EU and in the context of EU cooperation with third countries. Special consideration is given to the compatibility of EU policies with international labour standards along with the fundamental rights and approach to fairness laid down in the EU Treaties. The contributions to this book showcase the various uses and potential of social science and humanities research in assessing, informing and shaping EU migration policies. Leading scholars and experts have brought together the latest knowledge available to reappraise the added value of the EU in this area. Their reflections and findings point to the need to develop a revised set of EU policy priorities in implementing a new generation of legal pathways for migration. more...
- Published
- 2017
100. Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice : a retrospective cross-sectional analysis
- Author
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Capdevila Castillón, Jaume, Sevilla, Isabel, Alonso, Vicente, Antón Aparicio, Luís, Jiménez Fonseca, Paula, Grande, Enrique, Reina, Juan José, Manzano, José Luís, Alonso Lájara, Juan Domingo, Barriuso, Jorge, Castellano, Daniel, Medina, Javier, López, Carlos, Segura, Ángel, Carrera, Sergio, Crespo, Guillermo, Fuster, José, Munarriz, Javier, García Alfonso, Pilar, Universitat Autònoma de Barcelona, and [Capdevila,J] Medical Oncology Department, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Spain. [Sevilla,I] Medical Oncology Department, Virgen de la Victoria University Hospital, Málaga, Spain. [Alonso,V] Medical Oncology Department, Miguel Servet University Hospital, Zaragoza, Spain. [Antón Aparicio,L] Medical Oncology Department, University Hospital Complex, As Xubias, A Coruña, Spain. [Jiménez Fonseca,P] Medical Oncology Department, Asturias Central University Hospital, Oviedo, Spain. [Grande,E] Medical Oncology Department, Ramón y Cajal University Hospita, Madrid, Spain. [Reina,JJ] Medical Oncology Department, Virgen Macarena University Hospital, Sevilla, Spain. [Manzano,JL] Medical Oncology Department, Catalan Oncology Institute (ICO-Badalona), Germans Trias i Pujol University Hospital, Barcelona, Spain. [Alonso Lájara,JD] Medical Oncology Department, Virgen de la Arrixaca University Hospital, Murcia, Spain. [Barriuso,J] Medical Oncology Department, La Paz University Hospital, Madrid, Spain. [Castellano,D] Medical Oncology Department, 12 de Octubre University Hospital, Madrid, Spain. [Medina,J] Medical Oncology Department, Toledo Hospital Complex, Toledo, Spain. [López,C] Medical Oncology Department, La Fe University Hospital, Valencia, Spain. [Carrera,S] Medical Oncology Department, Cruces University Hospital, Vizcaya, Spain. [Crespo,G] Medical Oncology Department, Burgos University Hospital, Burgos, Spain. [Fuster,J] Medical Oncology Department, Son Dureta University Hospital, Palma de Mallorca, Spain. [Munarriz,J] Medical Oncology Department, Castellón Provincial Hospital Consortium, Castellón de la Plana, Spain. [García Alfonso,P] Medical Oncology Department, Gregorio Marañon Hospital, Madrid, Spain. more...
- Subjects
Oncology ,Male ,Cancer Research ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings] ,medicine.medical_treatment ,humanos ,Sunitnib ,adolescente ,Kaplan-Meier Estimate ,Neuroendocrine tumors ,Pharmacology ,Somatostatin analogues ,Clinical practice ,Lanreotide ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,chemistry.chemical_compound ,Neuroendocrine tumours ,Antineoplastic Combined Chemotherapy Protocols ,Sunitinib ,tumores neuroendocrinos ,Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Pancreatic Neoplasms::Carcinoma, Islet Cell::Somatostatinoma [Medical Subject Headings] ,antineoplásicos ,Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles [Medical Subject Headings] ,mediana edad ,Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings] ,Aged, 80 and over ,anciano ,protocolos de quimioterapia antineoplásica combinada ,Estudios Prospectivos ,Middle Aged ,adulto ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings] ,adulto joven ,Neuroendocrine Tumors ,Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Angiogenesis Modulating Agents::Angiogenesis Inhibitors [Medical Subject Headings] ,Female ,Somatostatin ,medicine.drug ,Research Article ,Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors [Medical Subject Headings] ,Adult ,estimación de Kaplan-Meier ,medicine.medical_specialty ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings] ,Adolescent ,Check Tags::Male [Medical Subject Headings] ,Antineoplastic Agents ,Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrroles [Medical Subject Headings] ,Peptides, Cyclic ,Péptidos Cíclicos ,Young Adult ,Internal medicine ,Genetics ,medicine ,Humans ,Everolimus ,Chemicals and Drugs::Polycyclic Compounds::Macrocyclic Compounds::Peptides, Cyclic [Medical Subject Headings] ,Aged ,Retrospective Studies ,Sirolimus ,Chemotherapy ,Inhibidores de la Angiogénesis ,business.industry ,estudios retrospectivos ,Retrospective cohort study ,medicine.disease ,Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Sirolimus [Medical Subject Headings] ,Clinical trial ,Somatostatina ,somatostatina ,Cross-Sectional Studies ,chemistry ,Combination treatment ,péptidos ,Tumores Neuroendocrinos ,Cross-sectional analysis ,business ,Peptides ,estudios transversales - Abstract
Background: Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine tumours (NETs). Herein, we investigate the use of these treatment combinations in clinical practice. Methods: This retrospective cross-sectional analysis of patients with NETs treated with the SSA lanreotide and targeted therapies at 35 Spanish hospitals evaluated the efficacy and safety of lanreotide treatment combinations in clinical practice. The data of 159 treatment combinations with lanreotide in 133 patients was retrospectively collected. Results: Of the 133 patients, with a median age of 59.4 (16-83) years, 70 (52.6 %) patients were male, 64 (48.1 %) had pancreatic NET, 23 (17.3 %) had ECOG PS >= 2, 41 (30.8 %) had functioning tumours, 63 (47.7 %) underwent surgery of the primary tumour, 45 (33.8 %) had received prior chemotherapy, and 115 (86.5 %) had received prior SSAs. 115 patients received 1 lanreotide treatment combination and 18 patients received between 2 and 5 combinations. Lanreotide was mainly administered in combination with everolimus (73 combinations) or sunitinib (61 combinations). The probability of being progression-free was 78.5 % (6 months), 68.6 % (12 months) and 57.0 % (18 months) for patients who only received everolimus plus lanreotide (n = 57) and 89.3 % (6 months), 73.0 % (12 months), and 67.4 % (18 months) for patients who only received sunitinib and lanreotide (n = 50). In patients who only received everolimus plus lanreotide the median time-to-progression from the initiation of lanreotide combination treatment was 25.8 months (95 % CI, 11.3, 40.3) and it had not yet been reached among the subgroup of patients only receiving sunitinib plus lanreotide. The safety profile of the combination treatment was comparable to that of the targeted agent alone. Conclusions: The combination of lanreotide and targeted therapies, mainly everolimus and sunitinib, is widely used in clinical practice without unexpected toxicities and suggests efficacy that should be explored in randomized prospective clinical trials., We thank the participating investigators: Veronica Calderero, Hospital de Barbastro (Huesca); Juana Cano, Hospital General de Ciudad Real; Nieves Diaz, Hospital Universitario (San Juan - Alicante); Emma Dotor, Hospital Parc Tauli (Sabadell) Barcelona; Maria Pilar Escudero, Hospital Clinico Universitario Lozano Blesa (Zaragoza); Jose Luis Firvida, Complexo Hospitalario Universitario de Ourense; Maria Jose Gomez, Hospital Puerta del Mar (Cadiz); Encarnacion Jimenez, Hospital de Jerez (Cadiz); Luis Leon, Hospital Clinico Universitario (Santiago de Compostela); Natalia Lupion, Hospital de Merida (Badajoz); David Marrupe, Hospital de Mostoles (Madrid); Miguel Navarro, Hospital Clinico Universitario (Salamanca); Miguel Ruiz Lopez de Tejada, Hospital Punta de Europa (Algeciras - Cadiz); Raquel Serrano, Hospital Reina Sofia (Cordoba); Diego Soto, Hospital Clinico Universitario (Valladolid); Alexandre Teule, Institut Catala d'Oncologia, Hospital Duran i Reynals (Barcelona); Francisca Vazquez, Hospital Clinico Universitario (Santiago de Compostela). We thank Ignasi Gich Saladich who provided support for the statistical analyses at the behest of the coordinating investigators and Aurora O'Brate who provided medical writing services subsequent to the initial draft of the manuscript, including requesting additional statistical analyses, collation of all author comments, formatting to adapt to publishing requirements, and help with submission. External commercial funding was not received for the retrospective analysis, but Ipsen Pharma, Spain provided funding for the medical writing services. more...
- Published
- 2015
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