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in the treatment of early osteoartrosis, analgesics and non-steroidal anti-inflammatory drugs are frequently used to relieve pain. Currently, platelet rich plasma is used as an alternative in the treatment of osteoartrosis. The aim of this study was to evaluate the effect of platelet rich plasma compared to paracetamol as a treatment for patients with knee osteoartrosis grade I.we evaluated 42 patients who were randomized into two groups. Group one was treated with 5 mL of platelet rich plasma in two applications, while group two was treated with 1 gr of oral paracetamol every 8 hours for 30 days. Both patient groups received supervised physical rehabilitation during the 6 month observation period. Peripheral blood samples were taken to measure plasma IL-1β, TNF-a and TGF-β1 levels at day 0 and at 6 months post-treatment. Clinical evaluation was conducted using the KOOS at the start of the study and for every subsequent month during the study period.the Knee injury and Osteoarthritis Outcome Score (KOOS) for group one at the start of the treatment was measured at 30.1 points, whereas at the end, it was measured at 48.2 points, showing a clinical improvement of 60%. There were no statistically significant differences in IL-1β and TNF-a levels between groups treated either with platelet rich plasma or paracetamol.Our patients treated with platelet rich plasma showed a statistically significant increase in the serum levels of TGF-β1, which was associated with an improvement in the clinical evaluation used (KOOS).Antecedentes: la osteoartrosis se caracteriza por dolor, rigidez articular y crepitación, con datos radiológicos específicos. El dolor se controla con analgésicos y antiinflamatorios no esteroides. En la actualidad, el plasma rico en plaquetas es una alternativa de tratamiento de esta enfermedad. Objetivo: comparar el efecto del plasma rico en plaquetas versus paracetamol en el tratamiento de pacientes con osteoartrosis de rodilla grado I. Material y métodos: ensayo prospectivo y experimental en el que se estudiaron 42 pacientes que se asignaron al azar a dos grupos. Al grupo 1 (experimental) se le indicaron 5 mL de plasma rico en plaquetas, en dos aplicaciones; el grupo 2 (control) se trató con 1 g de paracetamol oral cada 8 horas durante 30 días. Ambos grupos recibieron terapia física supervisada, con un tiempo de seguimiento total de seis meses. Para determinar las concentraciones de sangre periférica se tomaron muestras de IL-1β, TNF-a y TGF-β en plasma el día 0 y a los 6 meses. La valoración clínica se realizó con el Knee injury and Osteoarthritis Outcome Score (KOOS) al inicio y mensualmente durante el estudio. Resultados: los resultados de IL-1β y TNF-a no mostraron diferencia significativa entre los grupos tratados con plasma rico en plaquetas y paracetamol. La escala KOOS para el grupo 1 al inicio del tratamiento fue de 30.1 puntos y al finalizar el tratamiento 48.2 puntos, con mejoría clínica de 60%. Conclusiones: los pacientes tratados con plasma rico en plaquetas tuvieron un incremento significativo en las concentraciones séricas de TGF-β1 que se asoció con la mejoría clínica relacionada con el KOOS.

One of the most challenging aspects of a revision knee arthroplasty is the management of bone loss. The OBJECTIVE of the study is to show the capability to augment bone mineral density in areas with bone loss with platelet-derived growth factors.Randomized, prospective, blinded study in patients who underwent a total knee replacement revision with tibial-damaged metaphyseal bone were randomly allocated to have a revision total knee arthroplasty and to fill the bone defects with lyophilized bone allograft mixed with platelet growth factors (experimental group, n= 9) or with lyophilized bone allograft alone (control group, n= 7). To evaluate bone mineral density between groups, dual-energy X-ray absorptiometry (DEXA) was performed preoperatively, at 1 month, 6 months and 1 year after surgery.The study was comprised of a total of 16 patients. We found no significant differences observed during the follow-up between groups in mineral bone density.Use of platelet-derived growth factors does not improve bone mineral density in patients with revision knee arthroplasty.uno de los aspectos más desafiantes de la artroplastia de revisión de rodilla es el manejo de la pérdida ósea.demostrar la capacidad de incrementar la densidad mineral ósea en áreas con pérdida ósea, mediante el uso de plasma rico en plaquetas. MATERIAL Y MÉTODOS: estudio prospectivo, aleatorizado, cegado; efectuado con pacientes a quienes se realizó artroplastia de revisión de rodilla con pérdida ósea metafisiaria de tibia. Los pacientes se asignaron al azar a dos grupos para rellenar los defectos con aloinjerto óseo liofilizado con plasma rico en plaquetas (grupo experimental, n= 9), y otro grupo que sólo recibió el injerto óseo liofilizado (grupo control, n= 7). En ambos grupos la evaluación de la densidad mineral ósea se hizo con absorciometría de rayos X de energía dual (DXA) antes de la operación, al mes, seis meses, y un año después de la cirugía.se estudiaron 16 pacientes sin diferencias significativas entre ambos grupos en la densidad mineral ósea durante el periodo de seguimiento.el plasma rico en plaquetas no demostró incrementar la densidad mineral ósea en pacientes con defectos óseos por artroplastia de revisión de rodilla.

Communication amongst human beings is vital for the development and support of the human race. It is impressive how we have gone from smoke signals, carrier pigeons, ‘‘foot’’ or ‘‘horse’’ messengers, to land and air mail, fax, and telephones. However, nothing is as interesting and as incredible as communication through the internet and its derivations, like ‘‘social networks’’ and the use of the smartphone. This device allows the user to be connected with practically everybody, it even allows audio and video recording and to make commercial transactions. The question is, how does this impact health, science and medicine? The answer is not that simple, and we approach this topic in this issue of Medicina Universitaria