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3,077 results on '"Cao, Qian"'

64. Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease

Author

Jing Cai, Hao Wu, Chenxing Wang, Yujiao Chen, Dingli Zhang, Shiwei Guan, Beilei Fu, Yingli Jin, and Cao Qian

Subjects
Inflammatory bowel Disease (IBD), Sec1, fut2, Fucosylation, Death receptors 5 (DR5), Epithelial cell barrier, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Inflammatory bowel disease (IBD) is a common immune-mediated condition with its molecular pathogenesis remaining to be fully elucidated. This study aimed to deepen our understanding of the role of FUT2 in human IBD, by studying a new surrogate gene Sec1, a neighboring gene of Fut2 and Fut1 that co-encodes the α 1,2 fucosyltransferase in mice. CRISPR/Cas9 was used to prepare Sec1 knockout (Sec1 −/− ) mice. IBD was induced in mice using 3% w/v dextran sulphate sodium. Small interfering RNA (siRNA) was employed to silence Sec1 in murine colon cancer cell lines CT26.WT and CMT93. IBD-related symptoms, colonic immune responses, proliferation and apoptosis of colon epithelial cells were assessed respectively to determine the role of Sec1 in mouse IBD. Impact of Sec1 on the expression of death receptor 5 (DR5) and other apoptosis-associated proteins were determined. Sec1 knockout was found to be associated with deterioration of IBD in mice and elevated immune responses in the colonic mucosa. Silencing Sec1 in CT26.WT and CMT93 cells led to greater secretion of inflammatory cytokines IL-1β, IL-6 and TNF-α. Cell counting kit 8 (CCK8) assay, flow cytometry and TUNEL detection suggested that Sec1 expression promoted the proliferation of colon epithelial cells, inhibited cell apoptosis, reduced cell arrest in G0/G1 phase and facilitated repair of inflammatory injury. Over-expression of DR5 and several apoptosis-related effector proteins was noticed in Sec1 −/− mice and Sec1-silenced CT26.WT and CMT93 cells, supporting a suppressive role of Sec1 in cell apoptosis. Our results depicted important regulatory roles of Sec1 in mouse IBD, further reflecting the importance of FUT2 in the pathogenesis of human IBD.

Published
2023
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71. Photonic toroidal vortex

Author

Wan, Chenhao, Cao, Qian, Chen, Jian, Chong, Andy, and Zhan, Qiwen

Subjects
Physics - Optics
Abstract

Toroidal vortices are whirling disturbances rotating about a ring-shaped core while advancing in the direction normal to the ring orifice. Toroidal vortices are commonly found in nature and being studied in a wide range of disciplines. Here we report the experimental observation of photonic toroidal vortex as a new solution to Maxwell's equations with the use of conformal mapping. The helical phase twists around a closed loop leading to an azimuthal local orbital angular momentum density. The preparation of such intriguing light field may offer insights of extending toroidal vortex to other disciplines and find important applications in light-matter interaction, optical manipulation, photonic symmetry and topology, and quantum information., Comment: 4 figures

Published
2021
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92. Capo: Calibrating Device-to-Device Positioning with a Collaborative Network

Author

Wan, Kao, Wu, Zhaoxi, Cao, Qian, Zheng, Xiaotao, Li, Ziwei, Li, Tong, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Zhang, Feng, editor, Wang, Hua, editor, Barhamgi, Mahmoud, editor, Chen, Lu, editor, and Zhou, Rui, editor

Published
2023
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96. Optimization of Standard Object Color Spectrum Database Based on Human Eye Color Discrimination Threshold Cycle Algorithm

Author

Cao, Qian, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Xu, Min, editor, Yang, Li, editor, Zhang, Linghao, editor, and Yan, Shu, editor

Published
2023
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97. Current Status of Research on Wet Hydrogen Sulfide/Seawater Corrosion Resistant Anti-Corrosion Coatings for Steel Structures in Marine Environments

Author

CHEN Xiangxiang, ZHANG Pu, ZENG Xian, SHEN Huanrong, CHENG Xudong, GE Shenyu, CAO Qian, ZHANG Yun

Subjects
seawater；wet hydrogen sulfide；steel structure；anti-corrosion coating；biological friendliness；present situation, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology
Abstract

Due to the complexity of the deep-sea marine environment，offshore engineering equipment such as deep-sea oil and gas exploitation has suffered from seawater erosion and chemical corrosion for a long time.In this work，the characteristics and mechanism of wet hydrogen sulfide and seawater corrosion of steel structure materials were generally described.For hydrogen sulfide-resistant and seawater corrosion-resistant coatings，the current researches of the coating preparation technology and coating performance were summarized and summarized.Furthermore，the toxicity effects of common metals and the evaluation methods of marine biological friendliness were summarized，which could provide technical support for the design of green coating formulation components and application risk assessment.

Published
2023
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