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1,238 results on '"Canzonieri, Vincenzo"'

51. Secretagogue effect of PDE4 inhibitor apremilast on human salivary gland organoids obtained from primary Sjögren's syndrome patients

Author

Manfrè, Valeria, primary, Parisi, Salvatore, additional, Caligiuri, Isabella, additional, Repetto, Ombretta, additional, Zabotti, Alen, additional, Pegolo, Enrico, additional, Fabro, Cinzia, additional, De Vita, Salvatore, additional, Canzonieri, Vincenzo, additional, Di Loreto, Carla, additional, Rizzolio, Flavio, additional, and Quartuccio, Luca, additional

Published
2023
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53. Prospective, Multicenter Phase II Trial of Non-Pegylated Liposomal Doxorubicin Combined with Ifosfamide in First-Line Treatment of Advanced/Metastatic Soft Tissue Sarcomas

Author

Buonadonna, Angela, primary, Scalone, Simona, additional, Lombardi, Davide, additional, Fumagalli, Arianna, additional, Guglielmi, Alessandra, additional, Lestuzzi, Chiara, additional, Polesel, Jerry, additional, Canzonieri, Vincenzo, additional, Lamon, Stefano, additional, Giovanis, Petros, additional, Gagno, Sara, additional, Corona, Giuseppe, additional, Mascarin, Maurizio, additional, Belluco, Claudio, additional, De Paoli, Antonino, additional, Fasola, Gianpiero, additional, Puglisi, Fabio, additional, and Miolo, Gianmaria, additional

Published
2023
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57. Sleeping beauty genetic screen identifies miR-23b::BTBD7 gene interaction as crucial for colorectal cancer metastasis

Author

Grisard, Eleonora, Coan, Michela, Cesaratto, Laura, Rigo, Ilenia, Zandonà, Luigi, Paulitti, Alice, Andreuzzi, Eva, Rampioni Vinciguerra, Gian Luca, Poletto, Evelina, Del Ben, Fabio, Brisotto, Giulia, Biscontin, Eva, Turetta, Matteo, Dassi, Erik, Mirnezami, Alex, Canzonieri, Vincenzo, Vecchione, Andrea, Baldassarre, Gustavo, Mongiat, Maurizio, Spizzo, Riccardo, and Nicoloso, Milena S.

Published
2019
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58. Silver nitroprusside as an efficient chemodynamic therapeutic agent and a peroxynitrite nanogenerator for targeted cancer therapies.

Author

Asif, Kanwal, Adeel, Muhammad, Rahman, Md. Mahbubur, Sfriso, Andrea Augusto, Bartoletti, Michele, Canzonieri, Vincenzo, Rizzolio, Flavio, and Caligiuri, Isabella

Abstract

Schematic representation of multiple ROS-generation-based tumor-therapy approach of AgNP. [Display omitted] • A simple mixing procedure has been utilized to synthesize bimetallic silver nitroprusside (AgNP) as CDT agent together with peroxynitrite generator. • AgNP decomposes more endogenous H 2 O 2 to produce highly toxic radicals. • AgNP are involved in the inhibition of AKT pathway, which is involved in cell survival, angiogenesis, proliferation, and apoptosis. • AgNP showed biocompatible nature towards normal mouse liver and ovarian organoids while are toxic on PDTO through altering the redox homeostasis. Chemodynamic therapy (CDT) holds great promise in achieving cancer therapy through Fenton and Fenton-like reactions, which generate highly toxic reactive species. However, CDT is limited by the lower amount of catalyst ions that can decompose already existing intracellular H 2 O 2 and produce reactive oxygen species (ROS) to attain a therapeutic outcome. To overcome these limitations, a tailored approach, which utilizes dual metals cations (Ag+, Fe2+) based silver pentacyanonitrosylferrate or silver nitroprusside (AgNP) were developed for Fenton like reactions that can specifically kill cancer cells by taking advantage of tumor acidic environment without used of any external stimuli. A simple solution mixing procedure was used to synthesize AgNP as CDT agent. AgNP were structurally and morphologically characterized, and it was observed that a minimal dose of AgNP is required to destroy cancer cells with limited effects on normal cells. Moreover, comprehensive in vitro studies were conducted to evaluate antitumoral mechanism. AgNP have an effective ability to decompose endogenous H 2 O 2 in cells. The decomposed endogenous H 2 O 2 generates several different types of reactive species (•OH, O 2 •−) including peroxynitrite (ONOO−) species as apoptotic inducers that kill cancer cells, specifically. Cellular internalization data demonstrated that in short time, AgNP enters in lysosomes, avoid degradation and due to the acidic pH of lysosomes significantly generate high ROS levels. These data are further confirmed by the activation of different oxidative genes. Additionally, we demonstrated the biocompatibility of AgNP on mouse liver and ovarian organoids as an ex vivo model while AgNP showed the therapeutic efficacy on patient derived tumor organoids (PDTO). This work demonstrates the therapeutic application of silver nitroprusside as a multiple ROS generator utilizing Fenton like reaction. Thereby, our study exhibits a potential application of CDT against HGSOC (High Grade Serous Ovarian Cancer), a deadly cancer through altering the redox homeostasis. [ABSTRACT FROM AUTHOR]

Published
2024
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66. Role of Close Endocervical Margin in Treatment Failure After Cervical Excision for Cervical Intraepithelial Neoplasia: A Retrospective Study

Author

Sopracordevole, Francesco, Carpini, Giovanni Delli, Del Fabro, Anna, Serri, Matteo, Alessandrini, Lara, Buttignol, Monica, Canzonieri, Vincenzo, Cagnacci, Angelo, and Ciavattini, Andrea

Subjects
Recurrence (Disease) -- Analysis, Lasers -- Analysis, Cervix dysplasia -- Analysis, Laser, Health
Abstract

* Context.--A significant negative trend in length of cone excision has been observed in recent years, leading to a higher percentage of positive endocervical excision margin and close ( Objective.--To evaluate the rate of disease persistence and recurrence after cervical excision for cervical intraepithelial neoplasia in relation to a close ( Design.--We retrospectively analyzed a cohort of patients with cervical intraepithelial neoplasia having a carbon dioxide laser cervical excision performed by the same operator. We evaluated the rate of positive follow-up in relation to the status of endocervical margin. Results.--We found a higher percentage of positivity at follow-up and recurrence rate between 13 and 24 months in patients with positive margin than for patients with negative or close endocervical margin (P =.005 and P = .006, respectively), with no difference between negative and close margin (7.0% versus 8.3%, P =.89, and 1.2% versus 0%, P =.83, respectively). Conclusions.--Women with close and negative endocervical margin presented similar risk of positivity at longterm follow-up, disease persistence, and recurrence between 13 and 24 months, so the histopathologic report of a free endocervical margin less than 1 mm should not categorize the patient as being at increased risk of treatment failure. Therefore, the only information that the pathologist should report is the state of the margin (positive or negative), regardless of the negative endocervical margin length. (Arch Pathol Lab Med. 2019;143:1006-1011; doi:10.5858/arpa.2018-0363-OA), Cervical intraepithelial neoplasia (CIN) is a potentially premalignant lesion of the uterine cervix, with a risk of progression to invasive cervical cancer related to the severity and size of the [...]

Published
2019
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68. Pre-treatment molecular profiling identifies predictive and prognostic fingerprints in locally advanced rectal cancer undergoing neoadjuvant chemoradiation: implications for treatment selection

Author

Pollesel, Sara, Lauretta, Andrea, Olivieri, Matteo, Foltran, Luisa, Guardascione, Michela, Milan, Noemi, Palazzari, Elisa, Innocente, Roberto, Navarria, Federico, Cannizzaro, Renato, Canzonieri, Vincenzo, Dalle Fratte, Chiara, Scarabel, Lucia, Toffoli, Giuseppe, De Mattia, Elena, Cecchin, Erika, and Belluco, Claudio

Published
2024
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70. Loss of CDKN1B induces an age‐related clonal hematopoietic disorder via Notch2 activity dysregulation

Author

Segatto, Ilenia, primary, Rampioni Vinciguerra, Gian Luca, additional, Pellarin, Ilenia, additional, Dall'Acqua, Alessandra, additional, Berton, Stefania, additional, Citron, Francesca, additional, D'Andrea, Sara, additional, Mungo, Giorgia, additional, Viotto, Davide, additional, Musco, Lorena, additional, Di Napoli, Arianna, additional, Aloe Spiriti, Maria Antonietta, additional, Canzonieri, Vincenzo, additional, Gattei, Valter, additional, Vecchione, Andrea, additional, Belletti, Barbara, additional, and Baldassarre, Gustavo, additional

Published
2023
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76. Genomic instability analysis in DNA from Papanicolaou test provides proof-of-principle early diagnosis of high-grade serous ovarian cancer.

Author

Paracchini, Lara, Mannarino, Laura, Romualdi, Chiara, Zadro, Riccardo, Beltrame, Luca, Fuso Nerini, Ilaria, Zola, Paolo, Laudani, Maria E., Pagano, Eva, Giordano, Livia, Fruscio, Robert, Landoni, Fabio, Franceschi, Silvia, Dalessandro, Maria L., Canzonieri, Vincenzo, Bocciolone, Luca, Lorusso, Domenica, Bosetti, Cristina, Raspagliesi, Francesco, and Garassino, Isabella M. G.

Subjects
DNA analysis, PAP test, OVARIAN cancer, GENOMICS, EARLY diagnosis, PROOF of concept
Abstract

Late diagnosis and the lack of screening methods for early detection define high-grade serous ovarian cancer (HGSOC) as the gynecological malignancy with the highest mortality rate. In the work presented here, we investigated a retrospective and multicentric cohort of 250 archival Papanicolaou (Pap) test smears collected during routine gynecological screening. Samples were taken at different time points (from 1 month to 13.5 years before diagnosis) from 113 presymptomatic women who were subsequently diagnosed with HGSOC (pre-HGSOC) and from 77 healthy women. Genome instability was detected through low-pass whole-genome sequencing of DNA derived from Pap test samples in terms of copy number profile abnormality (CPA). CPA values of DNA extracted from Pap test samples from pre-HGSOC women were substantially higher than those in samples from healthy women. Consistently with the longitudinal analysis of clonal pathogenic TP53 mutations, this assay could detect HGSOC presence up to 9 years before diagnosis. This finding confirms the continual shedding of tumor cells from fimbriae toward the endocervical canal, suggesting a new path for the early diagnosis of HGSOC. We integrated the CPA score into the EVA (early ovarian cancer) test, the sensitivity of which was 75% (95% CI, 64.97 to 85.79), the specificity 96% (95% CI, 88.35 to 100.00), and the accuracy 81%. This proof-of-principle study indicates that the early diagnosis of HGSOC is feasible through the analysis of genomic alterations in DNA from endocervical smears. Editor's summary: Ovarian cancer is often diagnosed at a late stage, which leads to increased patient mortality in part because of lack of early detection tests. Here, Paracchini et al. evaluated the use of archival Papanicolaou test smears as a source of tissue for early detection of ovarian cancer. The authors obtained DNA from these samples from which they performed shallow whole-genome sequencing and identified high copy number profile abnormality (CPA) correlated to ovarian cancer development. They created an early ovarian cancer test (EVA), providing a proof of principle for using Pap smears and CPA for early diagnosis of ovarian cancer. —Dorothy Hallberg [ABSTRACT FROM AUTHOR]

Published
2023
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78. Colonic Adenocarcinomas Harboring NTRK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 16 Cases and Review of the Literature

Author

Lasota, Jerzy, Chłopek, Małgorzata, Lamoureux, Jennifer, Christiansen, Jason, Kowalik, Artur, Wasąg, Bartosz, Felisiak-Gołąbek, Anna, Agaimy, Abbas, Biernat, Wojciech, Canzonieri, Vincenzo, Centonze, Giovanni, Chmielik, Ewa, Daum, Ondrej, Dubová, Magdalena, Dziuba, Ireneusz, Goertz, Sebastian, Góźdź, Stanisław, Guttmejer-Nasierowska, Anna, Haglund, Caj, Hałoń, Agnieszka, Hartmann, Arndt, Inaguma, Shingo, Iżycka-Świeszewska, Ewa, Kaczorowski, Maciej, Kita, Paweł, Kołos, Małgorzata, Kopczyński, Janusz, Michal, Michal, Milione, Massimo, Okoń, Krzysztof, Pęksa, Rafał, Pyzlak, Michał, Ristimäki, Ari, Ryś, Janusz, Szostak, Blażej, Szpor, Joanna, Szumiło, Justyna, Teresiński, Leszek, Waloszczyk, Piotr, Wejman, Jarosław, Wesołowski, Wojciech, and Miettinen, Markku

Published
2020
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79. Supplementary material from Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression

Author

Baglio, S. Rubina, primary, Lagerweij, Tonny, primary, Pérez-Lanzón, Maria, primary, Ho, Xuan Dung, primary, Léveillé, Nicolas, primary, Melo, Sonia A., primary, Cleton-Jansen, Anne-Marie, primary, Jordanova, Ekaterina S., primary, Roncuzzi, Laura, primary, Greco, Michelina, primary, van Eijndhoven, Monique A.J., primary, Grisendi, Giulia, primary, Dominici, Massimo, primary, Bonafede, Roberta, primary, Lougheed, Sinead M., primary, de Gruijl, Tanja D., primary, Zini, Nicoletta, primary, Cervo, Silvia, primary, Steffan, Agostino, primary, Canzonieri, Vincenzo, primary, Martson, Aare, primary, Maasalu, Katre, primary, Köks, Sulev, primary, Wurdinger, Tom, primary, Baldini, Nicola, primary, and Pegtel, D. Michiel, primary

Published
2023
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81. Supplementary Data from Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome

Author

Rossi, Davide, primary, Spina, Valeria, primary, Cerri, Michaela, primary, Rasi, Silvia, primary, Deambrogi, Clara, primary, De Paoli, Lorenzo, primary, Laurenti, Luca, primary, Maffei, Rossana, primary, Forconi, Francesco, primary, Bertoni, Francesco, primary, Zucca, Emanuele, primary, Agostinelli, Claudio, primary, Cabras, Antonello, primary, Lucioni, Marco, primary, Martini, Maurizio, primary, Magni, Michele, primary, Deaglio, Silvia, primary, Ladetto, Marco, primary, Nomdedeu, Josep F., primary, Besson, Caroline, primary, Ramponi, Antonio, primary, Canzonieri, Vincenzo, primary, Paulli, Marco, primary, Marasca, Roberto, primary, Larocca, Luigi M., primary, Carbone, Antonino, primary, Pileri, Stefano A., primary, Gattei, Valter, primary, and Gaidano, Gianluca, primary

Published
2023
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83. Supplementary Data from Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding

Author

Belletti, Barbara, primary, Vaidya, Jayant S., primary, D'Andrea, Sara, primary, Entschladen, Frank, primary, Roncadin, Mario, primary, Lovat, Francesca, primary, Berton, Stefania, primary, Perin, Tiziana, primary, Candiani, Ezio, primary, Reccanello, Sonia, primary, Veronesi, Andrea, primary, Canzonieri, Vincenzo, primary, Trovò, Mauro G., primary, Zaenker, Kurt S., primary, Colombatti, Alfonso, primary, Baldassarre, Gustavo, primary, and Massarut, Samuele, primary

Published
2023
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86. Extramammary Paget’s Disease of the Vulva and Concomitant Premalignant/Malignant Vulvar Lesions: A Potential Challenge in Diagnosis and Treatment

Author

Clemente, Nicolò, primary, Ciavattini, Andrea, additional, Valenti, Gaetano, additional, Zannier, Federica, additional, Di Giuseppe, Jacopo, additional, Delli Carpini, Giovanni, additional, Fichera, Mariasole, additional, Del Fabro, Anna, additional, Giorda, Giorgio, additional, Goteri, Gaia, additional, Canzonieri, Vincenzo, additional, and Sopracordevole, Francesco, additional

Published
2023
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88. Development and validation of a microRNA-based signature (MiROvaR) to predict early relapse or progression of epithelial ovarian cancer: a cohort study

Author

Bagnoli, Marina, Canevari, Silvana, Califano, Daniela, Losito, Simona, Maio, Massimo Di, Raspagliesi, Francesco, Carcangiu, Maria Luisa, Toffoli, Giuseppe, Cecchin, Erika, Sorio, Roberto, Canzonieri, Vincenzo, Russo, Daniela, Scognamiglio, Giosué, Chiappetta, Gennaro, Baldassarre, Gustavo, Lorusso, Domenica, Scambia, Giovanni, Zannoni, Gian Franco, Savarese, Antonella, Carosi, Mariantonia, Scollo, Paolo, Breda, Enrico, Murgia, Viviana, Perrone, Francesco, Pignata, Sandro, De Cecco, Loris, and Mezzanzanica, Delia

Published
2016
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93. The history of small extracellular vesicles and their implication in cancer drug resistance

Author

Palazzolo, Stefano, Canzonieri, Vincenzo, Rizzolio, Flavio, Palazzolo, Stefano, Canzonieri, Vincenzo, and Rizzolio, Flavio

Subjects
cancer, drug resistance, extra cellular vesicles, oncology, therapy, Cancer Research, Settore BIO/11 - Biologia Molecolare, extra cellular vesicle
Abstract

Small extracellular vesicles (EVs) in the last 20 years are demonstrated to possess promising properties as potential new drug delivery systems, biomarkers, and therapeutic targets. Moreover, EVs are described to be involved in the most important steps of tumor development and progression including drug resistance. The acquired or intrinsic capacity of cancer cells to resist chemotherapies is one of the greatest obstacles to overcome to improve the prognosis of many patients. EVs are involved in this mechanism by exporting the drugs outside the cells and transferring the drug efflux pumps and miRNAs in recipient cells, in turn inducing drug resistance. In this mini-review, the main mechanisms by which EVs are involved in drug resistance are described, giving a rapid and clear overview of the field to the readers.

Published
2022

94. Correction: PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability

Author

Giuffrida, Paolo, Arpa, Giovanni, Grillo, Federica, Klersy, Catherine, Sampietro, Gianluca, Ardizzone, Sandro, Fociani, Paolo, Fiocca, Roberto, Latella, Giovanni, Sessa, Fausto, D’Errico, Antonietta, Malvi, Deborah, Mescoli, Claudia, Rugge, Massimo, Nesi, Gabriella, Ferrero, Stefano, Furlan, Daniela, Poggioli, Gilberto, Rizzello, Fernando, Macciomei, Maria C., Santini, Donatella, Volta, Umberto, De Giorgio, Roberto, Caio, Giacomo, Calabrò, Antonio, Ciacci, Carolina, D’Armiento, Maria, Rizzo, Aroldo, Solina, Gaspare, Martino, Michele, Tonelli, Francesco, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Florena, Ada M., Biancone, Livia, Monteleone, Giovanni, Caronna, Roberto, Ciardi, Antonio, Elli, Luca, Caprioli, Flavio, Vecchi, Maurizio, D’Incà, Renata, Zingone, Fabiana, D’Odorico, Anna, Lenti, Marco Vincenzo, Oreggia, Barbara, Bonetti, Luca Reggiani, Astegiano, Marco, Biletta, Elena, Cantoro, Laura, Giannone, Antonino G., Orlandi, Augusto, Papi, Claudio, Perfetti, Vittorio, Quaquarini, Erica, Sandri, Giancarlo, Silano, Marco, Usai, Paolo, Barresi, Valeria, Ciccocioppo, Rachele, Luinetti, Ombretta, Pedrazzoli, Paolo, Pietrabissa, Andrea, Viglio, Alessandra, Paulli, Marco, Corazza, Gino R., Solcia, Enrico, Vanoli, Alessandro, and Di Sabatino, Antonio

Published
2020
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95. Analysis of A Disintegrin and Metalloprotease 17 (ADAM17) Expression as a Prognostic Marker in Ovarian Cancer Patients Undergoing First-Line Treatment Plus Bevacizumab

Author

Fabbi, Marina, primary, Costa, Delfina, additional, Russo, Daniela, additional, Arenare, Laura, additional, Gaggero, Gabriele, additional, Signoriello, Simona, additional, Scambia, Giovanni, additional, Pisano, Carmela, additional, Colombo, Nicoletta, additional, Losito, Nunzia Simona, additional, Filaci, Gilberto, additional, Spina, Anna, additional, Califano, Daniela, additional, Scognamiglio, Giosuè, additional, Gadducci, Angiolo, additional, Mezzanzanica, Delia, additional, Bagnoli, Marina, additional, Ferrini, Silvano, additional, Canzonieri, Vincenzo, additional, Chiodini, Paolo, additional, Perrone, Francesco, additional, and Pignata, Sandro, additional

Published
2022
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97. An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer

Author

Bartoletti, Michele, primary, Giorda, Giorgio, additional, Viel, Alessandra, additional, Fornasarig, Mara, additional, Zdjelar, Adrian, additional, Segatto, Enrica, additional, Sorio, Roberto, additional, Corsetti, Serena, additional, Scalone, Simona, additional, Nicoloso, Milena Sabrina, additional, Pivetta, Tania, additional, Lucia, Emilio, additional, Clemente, Nicolò, additional, Palazzari, Elisa, additional, Canzonieri, Vincenzo, additional, and Puglisi, Fabio, additional

Published
2022
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98. Italian consensus guidelines for the diagnostic work-up and follow-up of cystic pancreatic neoplasms

Author

Albarello, Luca, Camellini, Lorenzo, Cantù, Paolo, Conigliaro, Rita, Costamagna, Guido, Del Favero, Giuseppe, Del Vecchio Blanco, Giovanna, Di Sebastiano, Pierluigi, Fabbri, Carlo, Federici, Paolo, Funel, Niccola, Galli, Andrea, Gabbrielli, Armando, Graziani, Rossella, Guadagnini, Tiziana, Laghi, Andrea, Macarri, Giampiero, Magnolfi, Fabrizio, Marzioni, Marco, Monica, Fabio, Muscatiello, Nicola, Mutignani, Massimiliano, Pisani, Antonio, Scarano, Enrico, Serra, Carla, Spada, Marco, Visconti, Marco, Zambelli, Alessandro, Buscarini, Elisabetta, Pezzilli, Raffaele, Cannizzaro, Renato, Angelis, Claudio De, Gion, Massimo, Morana, Giovanni, Zamboni, Giuseppe, Arcidiacono, Paolo, Balzano, Gianpaolo, Barresi, Luca, Basso, Daniela, Bocus, Paolo, Calculli, Lucia, Capurso, Gabriele, Canzonieri, Vincenzo, Casadei, Riccardo, Crippa, Stefano, D’Onofrio, Mirko, Frulloni, Luca, Fusaroli, Pietro, Manfredi, Guido, Pacchioni, Donatella, Pasquali, Claudio, Rocca, Rodolfo, Ventrucci, Maurizio, Venturini, Silvia, Villanacci, Vincenzo, Zerbi, Alessandro, and Falconi, Massimo

Published
2014
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