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Abstract: The current trend in telecommunications networks addresses an All-IP vision, since most user applications are based on IP, and additionally, IP networks operation is simpler than other more complex ones. These new trends in multimedia communications are giving rise to an increasing need of quality of service (QoS). The Differentiated Services (DiffServ) QoS architecture will provide the means to help underlying technologies, like MPLS, to guarantee the QoS required to support data and real-time services. In DiffServ, QoS is mainly provided with traffic control at edge nodes, and this task is carried out by traffic conditioners. In this paper, we introduce a new policy function for traffic conditioning. Its ability to react to new network conditions makes end-users to get excess bandwidth in proportion to their contracted target rates. We call this method Proportional Excess Traffic conditionER (PETER). Through extensive simulations, we confirm the effectiveness of our approach in providing both a proportional excess bandwidth distribution and assured contracted target rates. [Copyright &y& Elsevier]

Objectives: Autoantibodies targeting intracellular proteins are common in various autoimmune diseases. In the context of myositis, the pathologic significance of these autoantibodies has been questioned due to the assumption that autoantibodies cannot enter living muscle cells. This study aims to investigate the validity of this assumption., Methods: Confocal immunofluorescence microscopy was employed to localise antibodies and other proteins of interest in myositis muscle biopsies. Bulk RNA sequencing was used to examine the transcriptomic profiles of 669 samples, including those from patients with myositis, disease controls and healthy controls. Additionally, antibodies from myositis patients were introduced into cultured myoblasts through electroporation, and their transcriptomic profiles were analysed using RNA sequencing., Results: In patients with myositis autoantibodies, antibodies accumulated inside myofibres in the same subcellular compartment as the autoantigen. Bulk RNA sequencing revealed that muscle biopsies from patients with autoantibodies targeting transcriptional regulators exhibited transcriptomic patterns consistent with dysfunction of the autoantigen. For instance, in muscle biopsies from patients with anti-PM/Scl autoantibodies recognising components of the nuclear RNA exosome complex, an accumulation of divergent transcripts and long non-coding RNAs was observed; these RNA forms are typically degraded by the nuclear RNA exosome complex. Introducing patient antibodies into cultured muscle cells recapitulated the transcriptomic effects observed in human disease. Further supporting evidence suggested that myositis autoantibodies recognising other autoantigens may also disrupt the function of their targets., Conclusions: This study demonstrates that, in myositis, autoantibodies are internalised into living cells, causing biological effects consistent with the disrupted function of their autoantigen., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ on behalf of EULAR.)