904 results on '"Campagne, P"'
Search Results
52. Diagramas de manejo de densidad para Pinus cooperi var. ornelasi (Martínez) Blanco en Durango, México
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Benedicto Vargas Larreta, Roberto Flores-Salas, Oscar Josué Tuero-Campagne, Gabriel Graciano-Ávila, Cristóbal Gerardo Aguirre-Calderón, and Francisco Cruz-Cobos
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aclareos ,ajuste simultáneo ,densidad máxima ,índice de espaciamiento relativo ,volumen residual ,Agriculture ,Forestry ,SD1-669.5 - Abstract
Se desarrollaron diagramas de manejo de densidad (DMD) con datos de 218 sitios permanentes establecidos en rodales puros de Pinus cooperi en Durango, México. Los DMD se basan en el índice de espaciamiento relativo y en tres ecuaciones no lineales que incluyen variables de rodal. La primera relaciona el diámetro cuadrático con la densidad y la altura dominante; la segunda estima el volumen con la biomasa aérea, el diámetro cuadrático y la altura dominante; y la tercera estima la biomasa a partir del diámetro cuadrático, la altura dominante y la densidad. La densidad máxima se estimó mediante regresión cuantílica ajustando la relación densidad-altura dominante. Las ecuaciones explicaron el 92 % (biomasa) y el 99 % (volumen) de la varianza observada en los datos. Los DMD fueron aplicados en la cuantificación y proyección del volumen y la biomasa en rodales de la especie, como apoyo en la toma de decisiones multiobjetivo.
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- 2024
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53. Determining the position of a single spin relative to a metallic nanowire
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Barbosa, J. F. da Silva, Lee, M., Campagne-Ibarcq, P., Jamonneau, P., Kubo, Y., Pezzagna, S., Meijer, J., Teraji, T., Vion, D., Esteve, D., Heeres, R. W., and Bertet, P.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The nanoscale localization of individual paramagnetic defects near an electrical circuit is an important step for realizing hybrid quantum devices with strong spin-microwave photon coupling. Here, we demonstrate the fabrication of an array of individual NV centers in diamond near a metallic nanowire deposited on top of the substrate. We determine the relative position of each NV center with $\sim$10\,nm accuracy, using it as a vector magnetometer to measure the field generated by passing a dc current through the wire., Comment: 6 pages, 5 figures
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- 2020
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54. Extreme Universe Space Observatory on a Super Pressure Balloon 1 calibration: from the laboratory to the desert
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Adams Jr., J. H., Allen, L., Bachman, R., Bacholle, S., Barrillon, P., Bayer, J., Bertaina, M., Blaksley, C., Blin-Bondil, S., Cafagna, F., Campana, D., Casolino, M., Christl, M. J., Cummings, A., Dagoret-Campagne, S., Damian, A. Diaz, Ebersoldt, A., Ebisuzaki, T., Escobar, J., Eser, J., Evrard, J., Fenu, F., Finch, W., Fornaro, C., Gorodetzky, P., Gregg, R., Guarino, F., Haungs, A., Hedber, W., Hunt, P., Jung, A., Kawasaki, Y., Kleifges, M., Kuznetsov, E., Mackovjak, S., Marcelli, L., Marszał, W., Medina-Tanco, G., Meyer, S. S., Miyamoto, H., Mastafa, M., Olinto, A. V., Osteria, G., Painter, W., Panico, B., Parizot, E., Paul, T., Perfetto, F., Picozza, P., Piotrowski, L. W., Plebaniak, Z., Polonski, Z., Prévôt, G., Przybylak, M., Rezazadeh, M., Ricci, M., Balanzar, J. C. Sanchez, Santangelo, A., Sarazin, F., Scotti, V., Shinozaki, K., Szabelski, J., Takizawa, Y., Wiencke, L., Young, R., and von Ballmoos, P.
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Astrophysics - Instrumentation and Methods for Astrophysics ,High Energy Physics - Experiment - Abstract
The Extreme Universe Space Observatory on a Super Pressure Balloon 1 (EUSO-SPB1) instrument was launched out of Wanaka, New Zealand, by NASA in April, 2017 as a mission of opportunity. The detector was developed as part of the Joint Experimental Missions for the Extreme Universe Space Observatory (JEM-EUSO) program toward a space-based ultra-high energy cosmic ray (UHECR) telescope with the main objective to make the first observation of UHECRs via the fluorescence technique from suborbital space. The EUSO-SPB1 instrument is a refractive telescope consisting of two 1m$^2$ Fresnel lenses with a high-speed UV camera at the focal plane. The camera has 2304 individual pixels capable of single photoelectron counting with a time resolution of 2.5$\mu$s. A detailed performance study including calibration was done on ground. We separately evaluated the properties of the Photo Detector Module (PDM) and the optical system in the laboratory. An end-to-end test of the instrument was performed during a field campaign in the West Desert in Utah, USA at the Telescope Array (TA) site in September 2016. The campaign lasted for 8 nights. In this article we present the results of the preflight laboratory and field tests. Based on the tests performed in the field, it was determined that EUSO-SPB1 has a field of view of 11.1$^\circ$ and an absolute photo-detection efficiency of 10%. We also measured the light flux necessary to obtain a 50% trigger efficiency using laser beams. These measurements were crucial for us to perform an accurate post flight event rate calculation to validate our cosmic ray search. Laser beams were also used to estimated the reconstruction angular resolution. Finally, we performed a flat field measurement in flight configuration at the launch site prior to the launch providing a uniformity of the focal surface better than 6%.
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- 2020
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55. The Tianlai Dish Pathfinder Array: design, operation and performance of a prototype transit radio interferometer
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Wu, Fengquan, Li, Jixia, Zuo, Shifan, Chen, Xuelei, Das, Santanu, Marriner, John P., Oxholm, Trevor M., Phan, Anh, Stebbins, Albert, Timbie, Peter T., Ansari, Reza, Campagne, Jean-Eric, Chen, Zhiping, Cong, Yanping, Huang, Qizhi, Li, Yichao, Liu, Tao, Liu, Yingfeng, Niu, Chenhui, Osinga, Calvin, Perdereau, Olivier, Peterson, Jeffrey B., Shi, Huli, Siebert, Gage, Sun, Shijie, Tian, Haijun, Tucker, Gregory S., Wang, Qunxiong, Wang, Rongli, Wang, Yougang, Wu, Yanlin, Xu, Yidong, Yu, Kaifeng, Yu, Zijie, Zhang, Jiao, Zhang, Juyong, and Zhu, Jialu
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Tianlai Dish Pathfinder Array is a radio interferometer designed to test techniques for 21~cm intensity mapping in the post-reionization universe as a means for measuring large-scale cosmic structure. It performs drift scans of the sky at constant declination. We describe the design, calibration, noise level, and stability of this instrument based on the analysis of about $\sim 5 \%$ of 6,200 hours of on-sky observations through October, 2019. Beam pattern determinations using drones and the transit of bright sources are in good agreement, and compatible with electromagnetic simulations. Combining all the baselines, we make maps around bright sources and show that the array behaves as expected. A few hundred hours of observations at different declinations have been used to study the array geometry and pointing imperfections, as well as the instrument noise behaviour. We show that the system temperature is below 80~K for most feed antennas, and that noise fluctuations decrease as expected with integration time, at least up to a few hundred seconds. Analysis of long integrations, from 10 nights of observations of the North Celestial Pole, yielded visibilities with amplitudes of 20-30~mK, consistent with the expected signal from the NCP radio sky with $<10\,$mK precision for $1 ~\mathrm{MHz} \times 1~ \mathrm{min}$ binning. Hi-pass filtering the spectra to remove smooth spectrum signal yields a residual consistent with zero signal at the $0.5\,$mK level., Comment: 30 pages, 38 figures
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- 2020
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56. Magnifying quantum phase fluctuations with Cooper-pair pairing
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Smith, W. C., Villiers, M., Marquet, A., Palomo, J., Delbecq, M. R., Kontos, T., Campagne-Ibarcq, P., Douçot, B., and Leghtas, Z.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Remarkably, complex assemblies of superconducting wires, electrodes, and Josephson junctions are compactly described by a handful of collective phase degrees of freedom that behave like quantum particles in a potential. The inductive wires contribute a parabolic confinement, while the tunnel junctions add a cosinusoidal corrugation. Usually, the ground state wavefunction is localized within a single potential well -- that is, quantum phase fluctuations are small -- although entering the regime of delocalization holds promise for metrology and qubit protection. A direct route is to loosen the inductive confinement and let the ground state phase spread over multiple Josephson periods, but this requires a circuit impedance vastly exceeding the resistance quantum and constitutes an ongoing experimental challenge. Here we take a complementary approach and fabricate a generalized Josephson element that can be tuned in situ between one- and two-Cooper-pair tunneling, doubling the frequency of the corrugation and thereby magnifying the number of wells probed by the ground state. We measure a tenfold suppression of flux sensitivity of the first transition energy, implying a twofold increase in the vacuum phase fluctuations., Comment: 11 pages, 8 figures
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- 2020
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57. Fink, a new generation of broker for the LSST community
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Möller, Anais, Peloton, Julien, Ishida, Emille E. O., Arnault, Chris, Bachelet, Etienne, Blaineau, Tristan, Boutigny, Dominique, Chauhan, Abhishek, Gangler, Emmanuel, Hernandez, Fabio, Hrivnac, Julius, Leoni, Marco, Leroy, Nicolas, Moniez, Marc, Pateyron, Sacha, Ramparison, Adrien, Turpin, Damien, Ansari, Réza, Allam Jr., Tarek, Bajat, Armelle, Biswas, Biswajit, Boucaud, Alexandre, Bregeon, Johan, Campagne, Jean-Eric, Cohen-Tanugi, Johann, Coleiro, Alexis, Dornic, Damien, Fouchez, Dominique, Godet, Olivier, Gris, Philippe, Karpov, Sergey, Gomez-Moran, Ada Nebot, Neveu, Jérémy, Plaszczynski, Stephane, Savchenko, Volodymyr, and Webb, Natalie
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Fink is a broker designed to enable science with large time-domain alert streams such as the one from the upcoming Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST). It exhibits traditional astronomy broker features such as automatised ingestion, annotation, selection and redistribution of promising alerts for transient science. It is also designed to go beyond traditional broker features by providing real-time transient classification which is continuously improved by using state-of-the-art Deep Learning and Adaptive Learning techniques. These evolving added values will enable more accurate scientific output from LSST photometric data for diverse science cases while also leading to a higher incidence of new discoveries which shall accompany the evolution of the survey. In this paper we introduce Fink, its science motivation, architecture and current status including first science verification cases using the Zwicky Transient Facility alert stream., Comment: accepted in MNRAS
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- 2020
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58. Generation of weakly nonlinear turbulence of internal gravity waves in the Coriolis facility
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Savaro, Clément, Campagne, Antoine, Linares, Miguel Calpe, Augier, Pierre, Sommeria, Joël, Valran, Thomas, Viboud, Samuel, and Mordant, Nicolas
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Physics - Fluid Dynamics - Abstract
We investigate experimentally stratified turbulence forced by waves. Stratified turbulence is present in oceans and it is expected to be dominated by nonlinear interaction of internal gravity waves as described by the Garrett & Munk spectrum. In order to reach turbulent regimes dominated by stratification we use the Coriolis facility in Grenoble (France) which large size enables us to reach regimes with both low Froude number and large Reynolds number. Stratification is obtained by using vertically linearly varying salt concentration and we force large scale waves in a $6\times6\times 1$ m$^3$ domain. We perform time-resolved PIV to probe the space-time structure of the velocity field. We observe a wide band spectrum which is made of waves. Discrete modes are observed due to the square shape of the flow container as well as a continuum part which appears consistent with an axisymmetric superposition of random weakly nonlinear waves. Our observations support the interpretation of turbulence of a strongly stratified fluid as wave turbulence of internal waves although our spectrum is quite different from the Garrett & Munk spectrum. Weak turbulence proceeds down to a small cutoff length scale (the buoyancy wavelength) at which a transition to more strongly nonlinear turbulence is expected., Comment: accepted for publication in Physical Review Fluids
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- 2020
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59. Adversarial training applied to Convolutional Neural Network for photometric redshift predictions
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Campagne, Jean-Eric
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Astrophysics - Instrumentation and Methods for Astrophysics ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
The use of Convolutional Neural Networks (CNN) to estimate the galaxy photometric redshift probability distribution by analysing the images in different wavelength bands has been developed in the recent years thanks to the rapid development of the Machine Learning (ML) ecosystem. Authors have set-up CNN architectures and studied their performances and some sources of systematics using standard methods of training and testing to ensure the generalisation power of their models. So far so good, but one piece was missing : does the model generalisation power is well measured? The present article shows clearly that very small image perturbations can fool the model completely and opens the Pandora's box of \textit{adversarial} attack. Among the different techniques and scenarios, we have chosen to use the Fast Sign Gradient one-step Method and its Projected Gradient Descent iterative extension as adversarial generator tool kit. However, as unlikely as it may seem these adversarial samples which fool not only a single model, reveal a weakness both of the model and the classical training. A revisited algorithm is shown and applied by injecting a fraction of adversarial samples during the training phase. Numerical experiments have been conducted using a specific CNN model for illustration although our study could be applied to other models - not only CNN ones - and in other contexts - not only redshift measurements - as it deals with the complexity of the boundary decision surface., Comment: 12 pages, 6 figures
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- 2020
60. Contributions to the 36th International Cosmic Ray Conference (ICRC 2019) of the JEM-EUSO Collaboration
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Abdellaoui, G., Abe, S., Adams Jr., J. H., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blaksley, C., Blanc, N., Błęcki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Pacheco, S. Briz, Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Csorna, S., Cummings, A., Dagoret-Campagne, S., Gónzalez, A. de Castro, De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Damian, A. Diaz, Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., Alvarado, C. González, Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Carretero, J. Hernández, Cruz, W. Hidber, Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Krizmanic, J. F., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Campano, L. López, Martínez, F. López, Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszał, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Mustafa, M., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleaánski, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Frías, M. D. Rodríguez, Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Cano, G. Sáaez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Balanzar, J. C. Sanchez, Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr., J., Weber, M., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S, Zotov, M. Yu., and Marchi, A. Zuccaro
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Compilation of papers presented by the JEM-EUSO Collaboration at the 36th International Cosmic Ray Conference (ICRC), held July 24 through August 1, 2019 in Madison, Wisconsin., Comment: links to the 24 papers published in arXiv
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- 2019
61. A phase I trial of the CDK 4/6 inhibitor palbociclib in pediatric patients with progressive brain tumors: A Pediatric Brain Tumor Consortium study (PBTC‐042)
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Van Mater, David, Gururangan, Sridharan, Becher, Oren, Campagne, Olivia, Leary, Sarah, Phillips, Joanna J, Huang, Jie, Lin, Tong, Poussaint, Tina Young, Goldman, Stewart, Baxter, Patricia, Dhall, Girish, Robinson, Giles, DeWire‐Schottmiller, Mariko, Hwang, Eugene I, Stewart, Clinton F, Onar‐Thomas, Arzu, Dunkel, Ira J, and Fouladi, Maryam
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Neurosciences ,Pediatric Research Initiative ,Clinical Research ,Rare Diseases ,Pediatric Cancer ,Clinical Trials and Supportive Activities ,Cancer ,Orphan Drug ,Hematology ,Pediatric ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Adolescent ,Adult ,Antineoplastic Agents ,Brain Neoplasms ,Child ,Child ,Preschool ,Cyclin-Dependent Kinase 4 ,Cyclin-Dependent Kinase 6 ,Disease Progression ,Female ,Humans ,Male ,Piperazines ,Protein Kinase Inhibitors ,Pyridines ,Young Adult ,brain tumor ,palbociclib ,PBTC‐ ,042 ,pharmacodynamics ,pharmacokinetics ,PBTC-042 ,Paediatrics and Reproductive Medicine ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Paediatrics - Abstract
BackgroundDisruption of cell-cycle regulators is a potential therapeutic target for brain tumors in children and adolescents. The aim of this study was to determine the maximum tolerated dose (MTD) and describe toxicities related to palbociclib, a selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitor in pediatric patients with progressive/refractory brain tumors with intact retinoblastoma protein.MethodsPalbociclib was administered orally starting at 50 mg/m2 daily for the first 21 days of a 28-day course. Dose escalation was according to the Rolling-6 statistical design in less heavily (stratum I) and heavily pretreated (stratum II) patients, and MTD was determined separately for each group. Pharmacokinetic studies were performed during the first course, and pharmacodynamic studies were conducted to evaluate relationships between drug levels and toxicities.ResultsA total of 21 patients were enrolled on stratum I and 14 patients on stratum II. The MTD for both strata was 75 mg/m2 . Palbociclib absorption (mean Tmax between 4.9 and 6.6 h) and elimination (mean half-life between 11.3 and 19.5 h) were assessed. The most common toxicity was myelosuppression. Higher palbociclib exposure was associated with grade 3/4 neutropenia and leukopenia. Dose limiting toxicities included grade 4 neutropenia and grade 3 thrombocytopenia and dehydration. No patients had an objective response to palbociclib therapy.ConclusionsPalbociclib was safely administered to children and adolescents at a dosage of 75 mg/m2 for 21 consecutive days followed by seven days of rest in both strata. Future studies will establish its optimal utilization in pediatric patients with brain tumors.
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- 2021
62. Design, operation and performance of the PAON4 prototype transit interferometer
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Ansari, R., Campagne, J. E, Charlet, D., Moniez, M., Pailler, C., Perdereau, O., Taurigna, M., Martin, J. M., Rigaud, F., Colom, P., Abbon, Ph., Magneville, Ch., Pezzani, J., Viou, C., Torchinsky, S. A., Huang, Q., and Zhang, J.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
PAON4 is an L-band (1250-1500 MHz) small interferometer operating in transit mode deployed at the Nan\c{c}ay observatory in France, designed as a prototype instrument for Intensity Mapping. It features four 5~meter diameter dishes in a compact triangular configuration, with a total geometric collecting area of $\sim75 \mathrm{m^2}$, and equipped with dual polarization receivers. A total of 36 visibilities are computed from the 8 independent RF signals by the software correlator over the full 250~MHz RF band. The array operates in transit mode, with the dishes pointed toward a fixed declination, while the sky drifts across the instrument. Sky maps for each frequency channel are then reconstructed by combining the time-dependent visibilities from the different baselines observed at different declinations. This paper presents an overview of the PAON4 instrument design and goals, as a prototype for dish arrays to map the Large Scale Structure in radio, using intensity mapping of the atomic hydrogen $21~\mathrm{cm}$ line. We operated PAON4 over several years and use data from observations in different periods to assess the array performance. We present preliminary analysis of a large fraction of this data and discuss crucial issues for this type of instrument, such as the calibration strategy, instrument response stability, and noise behaviour., Comment: 17 pages, 16 figures, accepted to MNRAS
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- 2019
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63. Quantum error correction of a qubit encoded in grid states of an oscillator
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Campagne-Ibarcq, P., Eickbusch, A., Touzard, S., Zalys-Geller, E., Frattini, N. E., Sivak, V. V., Reinhold, P., Puri, S., Shankar, S., Schoelkopf, R. J., Frunzio, L., Mirrahimi, M., and Devoret, M. H.
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Quantum Physics - Abstract
Quantum bits are more robust to noise when they are encoded non-locally. In such an encoding, errors affecting the underlying physical system can then be detected and corrected before they corrupt the encoded information. In 2001, Gottesman, Kitaev and Preskill (GKP) proposed a hardware-efficient instance of such a qubit, which is delocalised in the phase-space of a single oscillator. However, implementing measurements that reveal error syndromes of the oscillator while preserving the encoded information has proved experimentally challenging: the only realisation so far relied on post-selection, which is incompatible with quantum error correction (QEC). The novelty of our experiment is precisely that it implements these non-destructive error-syndrome measurements for a superconducting microwave cavity. We design and implement an original feedback protocol that incorporates such measurements to prepare square and hexagonal GKP code states. We then demonstrate QEC of an encoded qubit with unprecedented suppression of all logical errors, in quantitative agreement with a theoretical estimate based on the measured imperfections of the experiment. Our protocol is applicable to other continuous variable systems and, in contrast with previous implementations of QEC, can mitigate all logical errors generated by a wide variety of noise processes, and open a way towards fault-tolerant quantum computation., Comment: Text and figures edited for clarity. The claims of the paper remain the same. Author list fixed
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- 2019
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64. Identifying four wave resonant interactions in a surface gravity wave turbulence experiment
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Campagne, Antoine, Hassaini, Roumaissa, Redor, Ivan, Valran, Thomas, Viboud, Samuel, Sommeria, Joël, and Mordant, Nicolas
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Physics - Fluid Dynamics ,Nonlinear Sciences - Chaotic Dynamics - Abstract
The nonlinear dynamics of waves at the sea surface is believed to be ruled by the Weak Turbulence framework. In order to investigate the nonlinear coupling among gravity surface waves, we developed an experiment in the Coriolis facility which is a 13-m diameter circular tank. An isotropic and statistically stationary wave turbulence of average steepness of 10\% is maintained by two wedge wave makers. The space and time resolved wave elevation is measured using a stereoscopic technique. Wave-wave interactions are analyzed through third and fourth order correlations. We investigate specifically the role of bound waves generated by non resonant 3-wave coupling. Specifically, we implement a space-time filter to separate the dynamics of free waves (i.e. following the dispersion relation) from the bound waves. We observe that the free wave dynamics causes weak resonant 4-wave correlations. A weak level of correlation is actually the basis of the Weak Turbulence Theory. Thus our observations support the use of the Weak Turbulence to model gravity wave turbulence as is currently been done in the operational models of wave forecasting. Although in the theory bound waves are not supposed to contribute to the energy cascade, our observation raises the question of the impact of bound waves on dissipation and thus on energy transfers as well., Comment: accepted for publication in Physical Review Fluids
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- 2019
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65. Local monitoring of atmospheric transparency from the NASA MERRA-2 global assimilation system
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Guyonnet, A., Dagoret-Campagne, S., and Mondrik, N.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Ground-based astronomy has to correct astronomical observations from the impact of the atmospheric transparency and its variability.The current objective of several observatories is to achieve a sub-percent level monitoring of atmospheric transmission. A promising approach has been to combine internal calibration of the observations with various external meteorological data sources, upon avail-ability and depending on quality. In this paper we investigate the use of the NASA Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2) which is a general circulation model (GCM) and data assimilation system that renders freely available for any given site, at any time, all the parameters constraining atmospheric transmission. This paper demonstrates the extraction of the relevant atmospheric parameters for optical astronomy at two sites: Mauna Kea in Hawaii and Cerro Tololo InternationalObservatory in Chile. The temporal variability for the past eight years (annual, overnight and hourly), as well as the spatial gradients of ozone, precipitable water vapor, and aerosol optical depth is presented and their respective impacts on the atmospheric transparency is analyzed., Comment: 10 pages, 6 figures, accepted for publication in Journal of Astronomical Instrumentation
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- 2019
66. The energy cascade of surface wave turbulence: toward identifying the active wave coupling
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Campagne, Antoine, Hassaini, Roumaissa, Redor, Ivan, Sommeria, Joel, and Mordant, Nicolas
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Physics - Fluid Dynamics ,Nonlinear Sciences - Chaotic Dynamics - Abstract
We investigate experimentally turbulence of surface gravity waves in the Coriolis facility in Grenoble by using both high sensitivity local probes and a time and space resolved stereoscopic reconstruction of the water surface. We show that the water deformation is made of the superposition of weakly nonlinear waves following the linear dispersion relation and of bound waves resulting from non resonant triadic interaction. Although the theory predicts a 4-wave resonant coupling supporting the presence of an inverse cascade of wave action, we do not observe such inverse cascade. We investigate 4-wave coupling by computing the tricoherence i.e. 4-wave correlations. We observed very weak values of the tricoherence at the frequencies excited on the linear dispersion relation that are consistent with the hypothesis of weak coupling underlying the weak turbulence theory., Comment: proceedings of the Euromech-Ercoftac workshop "Turbulent Cascades II" organized in Ecole Centrale de Lyon in december 2017
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- 2019
67. Core Cosmology Library: Precision Cosmological Predictions for LSST
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Chisari, Nora Elisa, Alonso, David, Krause, Elisabeth, Leonard, C. Danielle, Bull, Philip, Neveu, Jérémy, Villarreal, Antonia, Singh, Sukhdeep, McClintock, Thomas, Ellison, John, Du, Zilong, Zuntz, Joe, Mead, Alexander, Joudaki, Shahab, Lorenz, Christiane S., Troester, Tilman, Sanchez, Javier, Lanusse, Francois, Ishak, Mustapha, Hlozek, Renée, Blazek, Jonathan, Campagne, Jean-Eric, Almoubayyed, Husni, Eifler, Tim, Kirby, Matthew, Kirkby, David, Plaszczynski, Stéphane, Slosar, Anze, Vrastil, Michal, and Wagoner, Erika L.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Core Cosmology Library (CCL) provides routines to compute basic cosmological observables to a high degree of accuracy, which have been verified with an extensive suite of validation tests. Predictions are provided for many cosmological quantities, including distances, angular power spectra, correlation functions, halo bias and the halo mass function through state-of-the-art modeling prescriptions available in the literature. Fiducial specifications for the expected galaxy distributions for the Large Synoptic Survey Telescope (LSST) are also included, together with the capability of computing redshift distributions for a user-defined photometric redshift model. A rigorous validation procedure, based on comparisons between CCL and independent software packages, allows us to establish a well-defined numerical accuracy for each predicted quantity. As a result, predictions for correlation functions of galaxy clustering, galaxy-galaxy lensing and cosmic shear are demonstrated to be within a fraction of the expected statistical uncertainty of the observables for the models and in the range of scales of interest to LSST. CCL is an open source software package written in C, with a python interface and publicly available at https://github.com/LSSTDESC/CCL., Comment: 38 pages, 18 figures, matches ApJS accepted version
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- 2018
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68. Principles and correction of 5’-splice site selection
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Florian Malard, Cameron D Mackereth, and Sébastien Campagne
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rna splicing ,5’-splice site ,u1 snrnp ,antisense oligonucleotides ,splicing modifiers ,Genetics ,QH426-470 - Abstract
In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing, and further regulation of the retained exons leads to alternatively spliced mRNA. The splicing reaction requires the stepwise assembly of the spliceosome, a macromolecular machine composed of small nuclear ribonucleoproteins (snRNPs). This review focuses on the early stage of spliceosome assembly, when U1 snRNP defines each intron 5’-splice site (5ʹss) in the pre-mRNA. We first introduce the splicing reaction and the impact of alternative splicing on gene expression regulation. Thereafter, we extensively discuss splicing descriptors that influence the 5ʹss selection by U1 snRNP, such as sequence determinants, and interactions mediated by U1-specific proteins or U1 small nuclear RNA (U1 snRNA). We also include examples of diseases that affect the 5ʹss selection by U1 snRNP, and discuss recent therapeutic advances that manipulate U1 snRNP 5ʹss selectivity with antisense oligonucleotides and small-molecule splicing switches.
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- 2022
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69. Engaging at the science-policy interface as an early-career researcher: experiences and perceptions in biodiversity and ecosystem services research
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Anna Filyushkina, Hyeonju Ryu, Andrew N. Kadykalo, Ranjini Murali, C. Sylvie Campagne, Carla-Leanne Washbourne, Sophie Peter, Nada Saidi, Thuan Sarzynski, Paola Fontanella Pisa, Giovanni Ávila-Flores, and Taha Amiar
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Sander Jacobs ,Barriers ,opportunities ,outcomes ,young scholars ,IPBES ,Human ecology. Anthropogeography ,GF1-900 ,Environmental sciences ,GE1-350 - Abstract
Effective knowledge exchange at science-policy interfaces (SPIs) can foster evidence-informed policy-making through the integration of a wide range of knowledge inputs. This is especially crucial for conservation and sustainable use of biodiversity and ecosystem services (ES), human well-being and sustainable development. Early-career researchers (ECRs) can contribute significantly to knowledge exchange at SPIs. Recognizing that, several capacity building programs focused on sustainability have been introduced recently. However, little is known about the experiences and perceptions of ECRs in relation to SPIs. Our study focused on SPI engagement of ECRs who conduct research on biodiversity and ES, as perceived and experienced. Specifically, we addressed ‘motivations’, ‘barriers’ and ‘opportunities and ‘benefits’. A total of 145 ECRs have completed the survey. Our results showed that ECRs were generally interested to engage in SPIs and believed it to be beneficial in terms of contributing to societal change, understanding policy processes and career development. Respondents perceived lack of understanding about involvement channels, engagement opportunities, funding, training, perceived credibility of ECRs by other actors and encouragement of senior colleagues as barriers to engaging in SPIs. Those who have already participated in SPIs generally saw fewer barriers and more opportunities. A key reason for dissatisfaction with experience in SPIs was a lack of impact and uptake of science-policy outputs by policymakers – an issue that likely extends beyond ECRs and implies the need for transformations in knowledge exchange within SPIs. In conclusion, based on insights from our survey, we outline several opportunities for increased and better facilitation of ECR engagement in SPIs.
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- 2022
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70. Combining Ecological Niche Models and ecosystem services indicators to assess impacts of climate change on kelp: application to French coasts
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Jules Pecquet, Maud Mouchet, Sylvie Campagne, Virginie Raybaud, Yoann Baulaz, François Gevaert, and Frida Ben Rais Lasram
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Evangelia Drakou ,Laminaria digitata ,climate change ,ecosystem services indicators ,ecological niche models ,projections ,Human ecology. Anthropogeography ,GF1-900 ,Environmental sciences ,GE1-350 - Abstract
Kelp forests, primarily Laminaria digitata, provide a broad range of ecosystem services of high social, economic, and ecological value and are considered one of the most productive ecosystems on the planet. Several studies have shown that kelp ecosystems are regressing in response to multiple stressors, especially climate change, which could lead to local extinctions. This may induce a decrease in the ecosystem services provided. Many studies use ecological niche models (ENM) to project potential future species distributions under climate change scenarios; however, no study has projected the future supply of ecosystem services resulting from shifts in species ranges and changes in biomass. In this study, using French coasts as a case study, we developed a new and reproducible methodological framework that combines ENM and ecosystem services indicators to assess impacts of climate change on ecosystem services supplied by kelp. To this end, we first identified ecosystem services currently provided by kelp and then used ENM to project future kelp distribution from 2041 to 2050 under climate scenarios RCP2.6 and RCP8.5. Finally, by estimating the biomass of kelp, we assessed the current and future ecosystem services provided by kelp.
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- 2022
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71. Straightforward synthesis of various chiral pyrimidines bearing a stereogenic center adjacent to the C-2 position, including C-terminal peptide isosteres
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Sahtel, Sami, Maamer, Chayma Ben, Besbes, Rafâa, Vrancken, Emmanuel, and Campagne, Jean-Marc
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- 2022
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72. First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere
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Abdellaoui, G., Abe, S., Adams Jr., J. H., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Błȩcki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, C. Catalano O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Damian, A. Diaz, Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Fernández-Soriano, J., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., Alvarado, C. González, Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Carretero, J. Hernández, Cruz, W. Hidber, Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larson, R., Larsson, O., Lee, J., Licandro, J., Campano, L. López, Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszał, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mastafa, M., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Nagataki, C. Moretto S., Naitamor, S., Napolitano, T., Naslund, W., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Pasqualino, G., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Frías, M. D. Rodríguez, Rodencal, M., Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Cano, G. Sáez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Balanzar, J. C. Sanchez, Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr., J., Weber, M., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S, Zotov, M. Yu., and Marchi, A. Zuccaro
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25$^{th}$ of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector., Comment: 18 pages, 14 figures
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- 2018
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73. Stabilized Cat in Driven Nonlinear Cavity: A Fault-Tolerant Error Syndrome Detector
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Puri, Shruti, Grimm, Alexander, Campagne-Ibarcq, Philippe, Eickbusch, Alec, Noh, Kyungjoo, Roberts, Gabrielle, Jiang, Liang, Mirrahimi, Mazyar, Devoret, Michel H., and Girvin, Steven M.
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Quantum Physics - Abstract
In quantum error correction, information is encoded in a high-dimensional system to protect it from the environment. A crucial step is to use natural, low-weight operations with an ancilla to extract information about errors without causing backaction on the encoded system. Essentially, ancilla errors must not propagate to the encoded system and induce errors beyond those which can be corrected. The current schemes for achieving this fault-tolerance to ancilla errors come at the cost of increased overhead requirements. An efficient way to extract error syndromes in a fault-tolerant manner is by using a single ancilla with strongly biased noise channel. Typically, however, required elementary operations can become challenging when the noise is extremely biased. We propose to overcome this shortcoming by using a bosonic-cat ancilla in a parametrically driven nonlinear cavity. Such a cat-qubit experiences only bit-flip noise and is stabilized against phase-flips. To highlight the flexibility of this approach, we illustrate the syndrome extraction process in a variety of codes such as qubit-based toric codes, bosonic cat- and Gottesman-Kitaev-Preskill (GKP) codes. Our results open a path for realizing hardware-efficient, fault-tolerant error syndrome extraction.
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- 2018
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74. Cavity Attenuators for Superconducting Qubits
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Wang, Z., Shankar, S., Minev, Z. K., Campagne-Ibarcq, P., Narla, A., and Devoret, M. H.
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Quantum Physics - Abstract
Dephasing induced by residual thermal photons in the readout resonator is a leading factor limiting the coherence times of qubits in the circuit QED architecture. This residual thermal population, of the order of $10^{-1}$--$10^{-3}$, is suspected to arise from noise impinging on the resonator from its input and output ports. To address this problem, we designed and tested a new type of band-pass microwave attenuator that consists of a dissipative cavity well thermalized to the mixing chamber stage of a dilution refrigerator. By adding such a cavity attenuator inline with a 3D superconducting cavity housing a transmon qubit, we have reproducibly measured increased qubit coherence times. At base temperature, through Hahn echo experiment, we measured $T_{2\mathrm{e}}/2T_1 = 1.0\,({+0.0}/{-0.1})$ for two qubits over multiple cooldowns. Through noise-induced dephasing measurement, we obtained an upper bound $2\times 10^{-4}$ on the residual photon population in the fundamental mode of the readout cavity, which to our knowledge is the lowest value reported so far. These results validate an effective method for protecting qubits against photon noise, which can be developed into a standard technology for quantum circuit experiments., Comment: 8 pages, 6 figures
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- 2018
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75. Analyzing billion-objects catalog interactively: Apache Spark for physicists
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Plaszczynski, S., Peloton, J., Arnault, C., and Campagne, J. E.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Apache Spark is a Big Data framework for working on large distributed datasets. Although widely used in the industry, it remains rather limited in the academic community or often restricted to software engineers. The goal of this paper is to show with practical uses-cases that the technology is mature enough to be used without excessive programming skills by astronomers or cosmologists in order to perform standard analyses over large datasets, as those originating from future galaxy surveys. To demonstrate it, we start from a realistic simulation corresponding to 10 years of LSST data taking (6 billions of galaxies). Then, we design, optimize and benchmark a set of Spark python algorithms in order to perform standard operations as adding photometric redshift errors, measuring the selection function or computing power spectra over tomographic bins. Most of the commands execute on the full 110 GB dataset within tens of seconds and can therefore be performed interactively in order to design full-scale cosmological analyses. A jupyter notebook summarizing the analysis is available at https://github.com/astrolabsoftware/1807.03078.
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- 2018
76. Progress in the Construction and Testing of the Tianlai Radio Interferometers
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Das, Santanu, Anderson, Christopher J., Ansari, Reza, Campagne, Jean-Eric, Charlet, Daniel, Chen, Xuelei, Chen, Zhiping, Cianciara, Aleksander J., Colom, Pierre, Cong, Yanping, Gayley, Kevin G., Geng, Jingchao, Hao, Jie, Huang, Qizhi, Keith, Celeste S., Li, Chao, Li, Jixia, Li, Yichao, Liu, Chao, Liu, Tao, Magneville, Christophe, Marriner, John P., Martin, Jean-Michel, Moniez, Marc, Oxholm, Trevor M., Pen, Ue-Li, Perdereau, Olivier, Peterson, Jeffrey B., Shi, Huli, Shu, Lin, Stebbins, Albert, Sun, Shijie, Timbie, Peter T., Torchinsky, Steve, Tucker, Gregory S., Wang, Guisong, Wang, Rongli, Wang, Xin, Wang, Yougang, Wu, Fengquan, Xu, Yidong, Yu, Kaifeng, Zhang, Jiao, Zhang, Juyong, Zhang, Le, Zhu, Jialu, and Zuo, Shifan
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Tianlai Pathfinder is designed to demonstrate the feasibility of using a wide field of view radio interferometers to map the density of neutral hydrogen in the Universe after the Epoch of Reionizaton. This approach, called 21~cm intensity-mapping, promises an inexpensive means for surveying the large-scale structure of the cosmos. The Tianlai Pathfinder presently consists of an array of three, 15~m $\times$ 40~m cylinder telescopes and an array of sixteen, 6~m diameter dish antennas located in a radio-quiet part of western China. The two types of arrays were chosen to determine the advantages and disadvantages of each approach. The primary goal of the Pathfinder is to make 3D maps by surveying neutral hydrogen over large areas of the sky %$20,000 {\rm deg}^2$ in two different redshift ranges: first at $1.03 > z > 0.78$ ($700 - 800$~MHz) and later at $0.21 > z > 0.12$ ($1170 - 1270$~MHz). The most significant challenge to $21$~cm intensity-mapping is the removal of strong foreground radiation that dwarfs the cosmological signal. It requires exquisite knowledge of the instrumental response, i.e. calibration. In this paper, we provide an overview of the status of the Pathfinder and discuss the details of some of the analysis that we have carried out to measure the beam function of both arrays. We compare electromagnetic simulations of the arrays to measurements, discuss measurements of the gain and phase stability of the instrument, and provide a brief overview of the data processing pipeline., Comment: 18 pages, 10 figures
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- 2018
77. Impact of dissipation on the energy spectrum of experimental turbulence of gravity surface waves
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Campagne, Antoine, Hassaini, Roumaissa, Redor, Ivan, Sommeria, Joël, Valran, Thomas, Viboud, Samuel, and Mordant, Nicolas
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Physics - Fluid Dynamics - Abstract
We discuss the impact of dissipation on the development of the energy spectrum in wave turbulence of gravity surface waves with emphasis on the effect of surface contamination. We performed experiments in the Coriolis facility which is a 13-m diameter wave tank. We took care of cleaning surface contamination as well as possible considering that the surface of water exceeds 100~m$^2$. We observe that for the cleanest condition the frequency energy spectrum shows a power law decay extending up to the gravity capillary crossover (14 Hz) with a spectral exponent that is increasing with the forcing strength and decaying with surface contamination. Although slightly higher than reported previously in the literature, the exponent for the cleanest water remains significantly below the prediction from the Weak Turbulence Theory. By discussing length and time scales, we show that weak turbulence cannot be expected at frequencies above 3 Hz. We observe with a stereoscopic reconstruction technique that the increase with the forcing strength of energy spectrum beyond 3~Hz is mostly due to the formation and strenghtening of bound waves., Comment: accepted for publication in Physical Review Fluids
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- 2018
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78. On-demand quantum state transfer and entanglement between remote microwave cavity memories
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Axline, Christopher, Burkhart, Luke, Pfaff, Wolfgang, Zhang, Mengzhen, Chou, Kevin, Campagne-Ibarcq, Philippe, Reinhold, Philip, Frunzio, Luigi, Girvin, S. M., Jiang, Liang, Devoret, M. H., and Schoelkopf, R. J.
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Quantum Physics - Abstract
Modular quantum computing architectures require fast and efficient distribution of quantum information through propagating signals. Here we report rapid, on-demand quantum state transfer between two remote superconducting cavity quantum memories through traveling microwave photons. We demonstrate a quantum communication channel by deterministic transfer of quantum bits with 76% fidelity. Heralding on errors induced by experimental imperfection can improve this to 87% with a success probability of 0.87. By partial transfer of a microwave photon, we generate remote entanglement at a rate that exceeds photon loss in either memory by more than a factor of three. We further show the transfer of quantum error correction code words that will allow deterministic mitigation of photon loss. These results pave the way for scaling superconducting quantum devices through modular quantum networks., Comment: main text 7 pages, 4 figures; supplement 16 pages, 16 figures
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- 2017
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79. Deterministic remote entanglement of superconducting circuits through microwave two-photon transitions
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Campagne-Ibarcq, P., Zalys-Geller, E., Narla, A., Shankar, S., Reinhold, P., Burkhart, L. D., Axline, C. J., Pfaff, W., Frunzio, L., Schoelkopf, R. J., and Devoret, M. H.
- Subjects
Quantum Physics - Abstract
Large-scale quantum information processing networks will most probably require the entanglement of distant systems that do not interact directly. This can be done by performing entangling gates between standing information carriers, used as memories or local computational resources, and flying ones, acting as quantum buses. We report the deterministic entanglement of two remote transmon qubits by Raman stimulated emission and absorption of a traveling photon wavepacket. We achieve a Bell state fidelity of 73 %, well explained by losses in the transmission line and decoherence of each qubit.
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- 2017
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80. The debut of chiral cyclic (alkyl)(amino)carbenes (CAACs) in enantioselective catalysis.
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Pichon, Delphine, Soleilhavoup, Michele, Morvan, Jennifer, Junor, Glen P, Vives, Thomas, Crévisy, Christophe, Lavallo, Vincent, Campagne, Jean-Marc, Mauduit, Marc, Jazzar, Rodolphe, and Bertrand, Guy
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Chemical Sciences - Abstract
The popularity of NHCs in transition metal catalysis has prompted the development of chiral versions as electron-rich neutral stereodirecting ancillary ligands for enantioselective transformations. Herein we demonstrate that cyclic (alkyl)(amino)carbene (CAAC) ligands can also engage in asymmetric transformations, thereby expanding the toolbox of available chiral carbenes.
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- 2019
81. Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury
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Bodo, Sahra, Campagne, Cécile, Thin, Tin Htwe, Higginson, Daniel S, Vargas, H Alberto, Hua, Guoqiang, Fuller, John D, Ackerstaff, Ellen, Russell, James, Zhang, Zhigang, Klingler, Stefan, Cho, HyungJoon, Kaag, Matthew G, Mazaheri, Yousef, Rimner, Andreas, Manova-Todorova, Katia, Epel, Boris, Zatcky, Joan, Cleary, Cristian R, Rao, Shyam S, Yamada, Yoshiya, Zelefsky, Michael J, Halpern, Howard J, Koutcher, Jason A, Cordon-Cardo, Carlos, Greco, Carlo, Haimovitz-Friedman, Adriana, Sala, Evis, Powell, Simon N, Kolesnick, Richard, and Fuks, Zvi
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Genetics ,Cancer ,Animals ,Cell Line ,Tumor ,Chromatin ,Homologous Recombination ,Humans ,Mice ,Neoplasm Proteins ,Neoplasms ,Reperfusion Injury ,Signal Transduction ,Small Ubiquitin-Related Modifier Proteins ,Ubiquitins ,DNA repair ,Oncology ,Vascular Biology ,Medical and Health Sciences ,Immunology - Abstract
Tumor cure with conventional fractionated radiotherapy is 65%, dependent on tumor cell-autonomous gradual buildup of DNA double-strand break (DSB) misrepair. Here we report that single-dose radiotherapy (SDRT), a disruptive technique that ablates more than 90% of human cancers, operates a distinct dual-target mechanism, linking acid sphingomyelinase-mediated (ASMase-mediated) microvascular perfusion defects to DNA unrepair in tumor cells to confer tumor cell lethality. ASMase-mediated microcirculatory vasoconstriction after SDRT conferred an ischemic stress response within parenchymal tumor cells, with ROS triggering the evolutionarily conserved SUMO stress response, specifically depleting chromatin-associated free SUMO3. Whereas SUMO3, but not SUMO2, was indispensable for homology-directed repair (HDR) of DSBs, HDR loss of function after SDRT yielded DSB unrepair, chromosomal aberrations, and tumor clonogen demise. Vasoconstriction blockade with the endothelin-1 inhibitor BQ-123, or ROS scavenging after SDRT using peroxiredoxin-6 overexpression or the SOD mimetic tempol, prevented chromatin SUMO3 depletion, HDR loss of function, and SDRT tumor ablation. We also provide evidence of mouse-to-human translation of this biology in a randomized clinical trial, showing that 24 Gy SDRT, but not 3×9 Gy fractionation, coupled early tumor ischemia/reperfusion to human cancer ablation. The SDRT biology provides opportunities for mechanism-based selective tumor radiosensitization via accessing of SDRT/ASMase signaling, as current studies indicate that this pathway is tractable to pharmacologic intervention.
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- 2019
82. Visual exploration of emotional scenes in aging during a free visualization taskdepending on arousal level of scenes
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Elie, Poncet, Galle, Nicolas, Guyader, Nathalie, Elena, Moro, and Campagne, Aurlie
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Research on emotion suggests that the attentional preference observed toward the negative stimuli in young adults tendsto disappear in normal aging and, sometimes, to shifts towards a preference for positive stimuli. However, this age-relatedeffect called the positivity effect may be modulated by several factors, such as the arousal level of stimuli. The presentstudy investigated visual exploration of natural scenes of different emotional valence in three age groups (young, middle-aged and older adults) depending on arousal level of scenes using an eye-tracking paradigm. Participants visualized pairsof emotional scenes either in low or high arousal condition. In contrast with the literature, the preliminary results revealeda reduction in prevalence of negative stimuli relative to other ones in older adults regardless of the arousal conditions. Nodifference between young adults and middle aged adults was observed.
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- 2019
83. JAX-COSMO: An End-to-End Differentiable and GPU Accelerated Cosmology Library
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Jean-Eric Campagne, François Lanusse, Joe Zuntz, Alexandre Boucaud, Santiago Casas, Minas Karamanis, David Kirkby, Denise Lanzieri, Austin Peel, and Yin Li
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Astronomy ,QB1-991 ,Astrophysics ,QB460-466 - Abstract
We present jax-cosmo, a library for automatically differentiable cosmological theory calculations. It uses the JAX library, which has created a new coding ecosystem, especially in probabilistic programming. As well as batch acceleration, just-in-time compilation, and automatic optimization of code for different hardware modalities (CPU, GPU, TPU), JAX exposes an automatic differentiation (autodiff) mechanism. Thanks to autodiff, jax-cosmo gives access to the derivatives of cosmological likelihoods with respect to any of their parameters, and thus enables a range of powerful Bayesian inference algorithms, otherwise impractical in cosmology, such as Hamiltonian Monte Carlo and Variational Inference. In its initial release, jax-cosmo implements background evolution, linear and non-linear power spectra (using halofit or the Eisenstein and Hu transfer function), as well as angular power spectra with the Limber approximation for galaxy and weak lensing probes, all differentiable with respect to the cosmological parameters and their other inputs. We illustrate how autodiff can be a game-changer for common tasks involving Fisher matrix computations, or full posterior inference with gradient-based techniques. In particular, we show how Fisher matrices are now fast, exact, no longer require any fine tuning, and are themselves differentiable. Finally, using a Dark Energy Survey Year 1 3x2pt analysis as a benchmark, we demonstrate how jax-cosmo can be combined with Probabilistic Programming Languages to perform posterior inference with state-of-the-art algorithms including a No U-Turn Sampler, Automatic Differentiation Variational Inference,and Neural Transport HMC. We further demonstrate that Normalizing Flows using Neural Transport are a promising methodology for model validation in the early stages of analysis. The software and documentation referred to in this paper can be found here.
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- 2023
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84. Population pharmacokinetics of crenolanib in children and young adults with brain tumors
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Bisbee, Cora, Campagne, Olivia, Gajjar, Amar, Tinkle, Christopher L., and Stewart, Clinton F.
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- 2022
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85. 3-wave and 4-wave interactions in gravity wave turbulence
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Aubourg, Quentin, Campagne, Antoine, Peureux, Charles, Ardhuin, Fabrice, Sommeria, Joel, Viboud, Samuel, and Mordant, Nicolas
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Physics - Fluid Dynamics - Abstract
The Weak Turbulence Theory is a statistical framework to describe a large ensemble of nonlinearly interacting waves. The archetypal example of such system is the ocean surface that is made of interacting surface gravity waves. Here we describe a laboratory experiment dedicated to probe the statistical properties of turbulent gravity waves. We setup an isotropic state of interacting gravity waves in the Coriolis facility (13~m diameter circular wave tank) by exciting waves at 1~Hz by wedge wavemakers. We implement a stereoscopic technique to obtain a measurement of the surface elevation that is resolved both in space and time. Fourier analysis shows that the laboratory spectra are systematically steeper than the theoretical predictions and than the field observations in the Black Sea by Leckler {\it et al. JPO} 2015. We identify a strong impact of surface dissipation on the scaling of the Fourier spectrum at the scales that are accessible in the experiments. We use bicoherence and tricoherence statistical tools in frequency and/or wavevector space to identify the active nonlinear coupling. These analyses are also performed on the field data by Leckler {\it et al.} for comparison with the laboratory data. 3-wave coupling are characterized and shown to involve mostly quasi resonances of waves with second or higher order harmonics. 4-wave coupling are not observed in the laboratory but are evidenced in the field data. We finally discuss temporal scale separation to explain our observations., Comment: accepted for publication in Phys. Rev. Fluids
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- 2017
86. Inductive-detection electron-spin resonance spectroscopy with $\mathbf{65}\,$spins$/\sqrt{\text{Hz}}$ sensitivity
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Probst, S., Bienfait, A., Campagne-Ibarcq, P., Pla, J. J., Albanese, B., Barbosa, J. F. Da Silva, Schenkel, T., Vion, D., Esteve, D., Mølmer, K., Morton, J. J. L., Heeres, R., and Bertet, P.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We report electron spin resonance spectroscopy measurements performed at millikelvin temperatures in a custom-built spectrometer comprising a superconducting micro-resonator at $7$ GHz and a Josephson parametric amplifier. Owing to the small ${\sim}10^{-12}\lambda^3$ magnetic resonator mode volume and to the low noise of the parametric amplifier, the spectrometer sensitivity reaches $260\pm40$ spins$/$echo and $65\pm10$ $\mathrm{spins}/\sqrt{\text{Hz}}$, respectively., Comment: 6 pages, 4 figures
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- 2017
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87. A direct method to compute the galaxy count angular correlation function including redshift-space distortions
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Campagne, J. -E., Plaszczynski, S., and Neveu, J.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
In the near future, cosmology will enter the wide and deep galaxy survey area allowing high-precision studies of the large scale structure of the universe in three dimensions. To test cosmological models and determine their parameters accurately, it is natural to confront data with exact theoretical expectations expressed in the observational parameter space (angles and redshift). The data-driven galaxy number count fluctuations on redshift shells, can be used to build correlation functions $C(\theta; z_1, z_2)$ on and between shells which can probe the baryonic acoustic oscillations, the distance-redshift distortions as well as gravitational lensing and other relativistic effects. Transforming the model to the data space usually requires the computation of the angular power spectrum $C_\ell(z_1, z_2)$ but this appears as an artificial and inefficient step plagued by apodization issues. In this article we show that it is not necessary and present a compact expression for $C(\theta; z_1, z_2)$ that includes directly the leading density and redshift space distortions terms from the full linear theory. It can be evaluated using a fast integration method based on Clenshaw-Curtis quadrature and Chebyshev polynomial series. This new method to compute the correlation functions without any Limber approximation, allows us to produce and discuss maps of the correlation function directly in the observable space and is a significant step towards disentangling the data from the tested models.
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- 2017
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88. Observing a quantum Maxwell demon at work
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Cottet, N., Jezouin, S., Bretheau, L., Campagne-Ibarcq, P., Ficheux, Q., Anders, J., Auffèves, A., Azouit, R., Rouchon, P., and Huard, B.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Statistical Mechanics - Abstract
In apparent contradiction to the laws of thermodynamics, Maxwell's demon is able to cyclically extract work from a system in contact with a thermal bath exploiting the information about its microstate. The resolution of this paradox required the insight that an intimate relationship exists between information and thermodynamics. Here, we realize a Maxwell demon experiment that tracks the state of each constituent both in the classical and quantum regimes. The demon is a microwave cavity that encodes quantum information about a superconducting qubit and converts information into work by powering up a propagating microwave pulse by stimulated emission. Thanks to the high level of control of superconducting circuits, we directly measure the extracted work and quantify the entropy remaining in the demon's memory. This experiment provides an enlightening illustration of the interplay of thermodynamics with quantum information.
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- 2017
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89. The EUSO@TurLab Project
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Miyamoto, H., Bertaina, M., Cotto, G., Forza, R., Manfrin, M., Mignone, M., Suino, G., Youssef, A., Caruso, R., Contino, G., Bacholle, S., Gorodetzky, P., Jung, A., Parizot, E., Prevôt, G., Barrillon, P., Dagoret-Campagne, S., Reina, J. Rabanal, and Blin, S.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The TurLab facility is a laboratory, equipped with a 5 m diameter and 1 m depth rotating tank, located in the Physics Department of the University of Turin. The tank has been built mainly to study problems where system rotation plays a key role in the fluid behaviour such as in atmospheric and oceanic flows at different scales. The tank can be filled with different fluids of variable density, which enables studies in layered conditions such as sea waves. The tank can be also used to simulate the terrestrial surface with the optical characteristics of different environments such as snow, grass, ocean, land with soil, stones etc., fogs and clouds. As it is located in an extremely dark place, the light intensity can be controlled artificially. Such capabilities of the TurLab facility are applied to perform experiments related to the observation of Extreme Energy Cosmic Rays (EECRs) from space using the fluorescence technique, as in the case of the JEM-EUSO mission, where the diffuse night brightness and artificial light sources can vary significantly in time and space inside the Field of View (FoV) of the telescope. Here we will report the currently ongoing activity at the TurLab facility in the framework of the JEM-EUSO mission (EUSO@TurLab)., Comment: 4 pages, 5 figures, "XXV ECRS 2016 Proceedings - eConf C16-09-04.3"
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- 2017
90. Angpow: a software for the fast computation of accurate tomographic power spectra
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Campagne, J. -E., Neveu, J., and Plaszczynski, S.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The statistical distribution of galaxies is a powerful probe to constrain cosmological models and gravity. In particular the matter power spectrum $P(k)$ brings information about the cosmological distance evolution and the galaxy clustering together. However the building of $P(k)$ from galaxy catalogues needs a cosmological model to convert angles on the sky and redshifts into distances, which leads to difficulties when comparing data with predicted $P(k)$ from other cosmological models, and for photometric surveys like LSST. The angular power spectrum $C_\ell(z_1,z_2)$ between two bins located at redshift $z_1$ and $z_2$ contains the same information than the matter power spectrum, is free from any cosmological assumption, but the prediction of $C_\ell(z_1,z_2)$ from $P(k)$ is a costly computation when performed exactly. The Angpow software aims at computing quickly and accurately the auto ($z_1=z_2$) and cross ($z_1 \neq z_2$) angular power spectra between redshift bins. We describe the developed algorithm, based on developments on the Chebyshev polynomial basis and on the Clenshaw-Curtis quadrature method. We validate the results with other codes, and benchmark the performance. Angpow is flexible and can handle any user defined power spectra, transfer functions, and redshift selection windows. The code is fast enough to be embedded inside programs exploring large cosmological parameter spaces through the $C_\ell(z_1,z_2)$ comparison with data. We emphasize that the Limber's approximation, often used to fasten the computation, gives wrong $C_\ell$ values for cross-correlations., Comment: Published in Astronomy & Astrophysics
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- 2017
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91. From data to QSP models: a pipeline for using Boolean networks for hypothesis inference and dynamic model building
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Putnins, M., Campagne, O., Mager, D. E., and Androulakis, I. P.
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- 2022
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92. The N5K Challenge: Non-Limber Integration for LSST Cosmology
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C. Danielle Leonard, Tassia Ferreira, Xiao Fang, Robert Reischke, Nils Schoeneberg, Tilman Tröster, David Alonso, Jean-Eric Campagne, François Lanusse, Anže Slosar, Mustapha Ishak, and LSST Dark Energy Science Collaboration
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Astronomy ,QB1-991 ,Astrophysics ,QB460-466 - Abstract
The rapidly increasing statistical power of cosmological imaging surveys requires us to reassess the regime of validity for various approximations that accelerate the calculation of relevant theoretical predictions. In this paper, we present the results of the 'N5K non-Limber integration challenge', the goal of which was to quantify the performance of different approaches to calculating the angular power spectrum of galaxy number counts and cosmic shear data without invoking the so-called 'Limber approximation', in the context of the Rubin Observatory Legacy Survey of Space and Time (LSST). We quantify the performance, in terms of accuracy and speed, of three non-Limber implementations: ${\tt FKEM (CosmoLike)}$, ${\tt Levin}$, and ${\tt matter}$, themselves based on different integration schemes and approximations. We find that in the challenge's fiducial 3x2pt LSST Year 10 scenario, ${\tt FKEM (CosmoLike)}$ produces the fastest run time within the required accuracy by a considerable margin, positioning it favourably for use in Bayesian parameter inference. This method, however, requires further development and testing to extend its use to certain analysis scenarios, particularly those involving a scale-dependent growth rate. For this and other reasons discussed herein, alternative approaches such as ${\tt matter}$ and ${\tt Levin}$ may be necessary for a full exploration of parameter space. We also find that the usual first-order Limber approximation is insufficiently accurate for LSST Year 10 3x2pt analysis on $\ell=200-1000$, whereas invoking the second-order Limber approximation on these scales (with a full non-Limber method at smaller $\ell$) does suffice.
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- 2023
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93. Population pharmacokinetic analysis of crizotinib in children with progressive/recurrent high-grade and diffuse intrinsic pontine gliomas
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Gibson, Elizabeth G., Campagne, Olivia, Selvo, Nicholas S., Gajjar, Amar, and Stewart, Clinton F.
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- 2021
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94. Teaching Methods Utilized During Medical Resuscitations in an Academic Emergency Department
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Weichenthal, Lori A., Ruegner, Rawnie, Sawtelle, Stacy, Campagne, Danielle, Ives, Crystal, and Comes, James
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Graduate Medical Education ,Medical Resuscitations - Abstract
Introduction: One important skill that an emergency medicine trainee must learn is the resuscitation of the critically ill patient. There is research describing clinical teaching strategies used in the emergency department (ED), but less is known about specific methods employed during actual medical resuscitations. Our objective was to identify and describe the teaching methods used during medical resuscitations.Methods: This was a prospective study involving review of 22 videotaped, medical resuscitations. Two teams of investigators first each reviewed and scored the amount and types of teaching observed for the same two videos. Each team then watched and scored 10 different videos. We calculated a Cohen’s kappa statistic for the first two videos. For the remaining 20 videos, we determined means and standard deviations , and we calculated independent two-tailed t-tests to compare means between different demographic and clinical situations.Results: The Cohen’s kappa statistic was K=0.89 with regard to number of teaching events and K=0.82 for types of teaching observed. Of the resuscitations reviewed, 12 were in coding patients. We identified 148 episodes of teaching, for an average of 7.4 per resuscitation. The amount of teaching did not vary with regard to whether the patient was coding or not (p=0.97), nor based onwhether the primary learner was a junior or senior resident (p=0.59). Questioning, affirmatives and advice-giving were the most frequently observed teaching methods.Conclusion: Teachers use concise teaching methods to instruct residents who lead medical resuscitations. Further research should focus on the effectiveness of these identified strategies.
- Published
- 2018
95. What evidence exists on how changes in marine ecosystem structure and functioning affect ecosystem services delivery? A systematic map protocol
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C. Sylvie Campagne, Joseph Langridge, Joachim Claudet, Rémi Mongruel, and Eric Thiébaut
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Ecosystem disservices ,Coastal ,Marine ,Biodiversity ,Nature’s contribution to people ,Spatio-temporal dynamics ,Environmental sciences ,GE1-350 - Abstract
Abstract Background The current biodiversity crisis calls for an urgent need to sustainably manage human uses of nature. The Ecosystem Services (ES) concept defined as « the benefits humans obtain from nature » support decisions aimed at promoting nature conservation. However, marine ecosystems, in particular, endure numerous direct pressures (e.g., habitat loss and degradation, overexploitation, pollution, climate change, and the introduction of non-indigenous species) all of which threaten ecosystem structure, functioning, and the very provision of ES. While marine ecosystems often receive less attention than terrestrial ecosystems in ES literature, it would also appear that there is a heterogeneity of knowledge within marine ecosystems and within the different ES provided. Hence, a systematic map on the existing literature will aim to highlight knowledge clusters and knowledge gaps on how changes in marine ecosystems influence the provision of marine ecosystem services. This will provide an evidence base for possible future reviews, and may help to inform eventual management and policy decision-making. Methods We will search for all evidence documenting how changes in structure and functioning of marine ecosystems affect the delivery of ES, across scientific and grey literature sources. Two bibliographic databases, Scopus and Web of Science Core Collection, will be used with a supplementary search undertaken in Google scholar. Multiple organisational websites related to intergovernmental agencies, supra-national or national structures, and NGOs will also be searched. Searches will be performed with English terms only without any geographic or temporal limitations. Literature screening, against predefined inclusion criteria, will be undertaken on title, abstract, and then full texts. All qualifying literature will be subjected to coding and meta-data extraction. No formal validity appraisal will be undertaken. Indeed, the map will highlight how marine ecosystem changes impact the ES provided. Knowledge gaps will be identified in terms of which ecosystem types, biodiversity components, or ES types are most or least studied and how these categories are correlated. Finally, a database will be provided, we will narratively describe this evidence base with summary figures and tables of pertinent study characteristics.
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- 2021
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96. Development of an ultra-sensitive human IL-33 biomarker assay for age-related macular degeneration and asthma drug development
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Elaine Mai, Joyce Chan, Levina Goon, Braeden K. Ego, Jack Bevers, Tiffany Wong, Manda Wong, Racquel Corpuz, Hongkang Xi, Jia Wu, Kellen Schneider, Dhaya Seshasayee, Michele Grimbaldeston, Gerald Nakamura, Vahan B. Indjeian, Menno van Lookeren Campagne, Kelly M. Loyet, and Laetitia Comps-Agrar
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IL-33 ,ST2 ,iPCR ,Biomarker ,Age-related macular degeneration ,Asthma ,Medicine - Abstract
Abstract Background Over the past decade, human Interleukin 33 (hIL-33) has emerged as a key contributor to the pathogenesis of numerous inflammatory diseases. Despite the existence of several commercial hIL-33 assays spanning multiple platform technologies, their ability to provide accurate hIL-33 concentration measurements and to differentiate between active (reduced) and inactive (oxidized) hIL-33 in various matrices remains uncertain. This is especially true for lower sample volumes, matrices with low hIL-33 concentrations, and matrices with elevated levels of soluble Interleukin 1 Receptor-Like 1 (sST2), an inactive form of ST2 that competes with membrane bound ST2 for hIL-33 binding. Results We tested the performance of several commercially available hIL-33 detection assays in various human matrices and found that most of these assays lacked the sensitivity to accurately detect reduced hIL-33 at biologically relevant levels (sub-to-low pg/mL), especially in the presence of human sST2 (hsST2), and/or lacked sufficient target specificity. To address this, we developed and validated a sensitive and specific enzyme-linked immunosorbent assay (ELISA) capable of detecting reduced and total hIL-33 levels even in the presence of high concentrations of sST2. By incorporating the immuno-polymerase chain reaction (iPCR) platform, we further increased the sensitivity of this assay for the reduced form of hIL-33 by ~ 52-fold. Using this hIL-33 iPCR assay, we detected hIL-33 in postmortem human vitreous humor (VH) samples from donors with age-related macular degeneration (AMD) and found significantly increased hIL-33 levels when compared to control individuals. No statistically significant difference was observed in aqueous humor (AH) from AMD donors nor in plasma and nasosorption fluid (NF) from asthma patients compared to control individuals. Conclusions Unlike existing commercial hIL-33 assays, our hIL-33 bioassays are highly sensitive and specific and can accurately quantify hIL-33 in various human clinical matrices, including those with high levels of hsST2. Our results provide a proof of concept of the utility of these assays in clinical trials targeting the hIL-33/hST2 pathway.
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- 2021
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97. Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study
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John C. Panetta, Olivia Campagne, Jessica Gartrell, Wayne Furman, and Clinton F. Stewart
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Therapeutics. Pharmacology ,RM1-950 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Sorafenib improves outcomes in adult hepatocellular carcinoma; however, hand foot skin reaction (HFSR) is a dose limiting toxicity of sorafenib that limits its use. HFSR has been associated with sorafenib systemic exposure. The objective of this study was to use modeling and simulation to determine whether using pharmacokinetically guided dosing to achieve a predefined sorafenib target range could reduce the rate of HFSR. Sorafenib steady‐state exposures (area under the concentration curve from 0 to 12‐h [AUC0–>12 h]) were simulated using published sorafenib pharmacokinetics at either a fixed dosage (90 mg/m2/dose) or a pharmacokinetically guided dose targeting an AUC0–>12 h between 20 and 55 h µg/ml. Dosages were either rounded to the nearest quarter of a tablet (50 mg) or capsule (10 mg). A Cox proportional hazard model from a previously published study was used to quantify HFSR toxicity. Simulations showed that in‐target studies increased from 50% using fixed doses with tablets to 74% using pharmacokinetically guided dosing with capsules. The power to observe at least 4 of 6 patients in the target range increased from 33% using fixed dosing with tablets to 80% using pharmacokinetically guided with capsules. The expected HFSR toxicity rate decreased from 22% using fixed doses with tablets to 16% using pharmacokinetically guided dosing with capsules. The power to observe less than 6 of 24 studies with HFSR toxicity increased from 51% using fixed dosing with tablets to 88% using pharmacokinetically guided with capsules. Our simulations provide the rationale to use pharmacokinetically guided sorafenib dosing to maintain effective exposures that potentially improve tolerability in pediatric clinical trials.
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- 2021
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98. Atmospheric Plasma Technique Assessment for the Development of a Polyfunctional End-use Polyester Fabric
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Krifa, Najla, Zouari, Riadh, Miled, Wafa, Behary, Nemeshwaree, Vieillard, Julien, Cheikhrouhou, Morched, and Campagne, Christine
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- 2021
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99. Extreme Universe Space Observatory on a Super Pressure Balloon 1 calibration: from the laboratory to the desert
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Adams, Jr., J. H., Allen, L., Bachman, R., Bacholle, S., Barrillon, P., Bayer, J., Bertaina, M., Blaksley, C., Blin-Bondil, S., Cafagna, F., Campana, D., Casolino, M., Christl, M. J., Cummings, A., Dagoret-Campagne, S., Damian, A. Diaz, Ebersoldt, A., Ebisuzaki, T., Escobar, J., Eser, J., Evrard, J., Fenu, F., Finch, W., Fornaro, C., Gorodetzky, P., Gregg, R., Guarino, F., Haungs, A., Hedber, W., Hunt, P., Jung, A., Kawasaki, Y., Kleifges, M., Kuznetsov, E., Mackovjak, S., Marcelli, L., Marszał, W., Medina-Tanco, G., Meyer, S. S., Miyamoto, H., Mastafa, M., Olinto, A. V., Osteria, G., Painter, W., Panico, B., Parizot, E., Paul, T., Perfetto, F., Picozza, P., Piotrowski, L. W., Plebaniak, Z., Polonski, Z., Prévôt, G., Przybylak, M., Rezazadeh, M., Ricci, M., Balanzar, J. C. Sanchez, Santangelo, A., Sarazin, F., Scotti, V., Shinozaki, K., Szabelski, J., Takizawa, Y., Wiencke, L., Young, R., and von Ballmoos, P.
- Published
- 2021
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100. Magnetic resonance with squeezed microwaves
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Bienfait, A., Campagne-Ibarcq, P., Holm-Kiilerich, A., Zhou, X., Probst, S., Pla, J. J., Schenkel, T., Vion, D., Esteve, D., Morton, J. J. L., Moelmer, K., and Bertet, P.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Vacuum fluctuations of the electromagnetic field set a fundamental limit to the sensitivity of a variety of measurements, including magnetic resonance spectroscopy. We report the use of squeezed microwave fields, which are engineered quantum states of light for which fluctuations in one field quadrature are reduced below the vacuum level, to enhance the detection sensitivity of an ensemble of electronic spins at millikelvin temperatures.} By shining a squeezed vacuum state on the input port of a microwave resonator containing the spins, we obtain a $1.2$\,dB noise reduction at the spectrometer output compared to the case of a vacuum input. This result constitutes a proof of principle of the application of quantum metrology to magnetic resonance spectroscopy., Comment: Main text : 19 pages, 6 figures. Followed by a 18-pages Supplementary Information section, which includes 6 Supplementary Figures
- Published
- 2016
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