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415 results on '"Calvo, Inmaculada"'

51. Consensus of the Spanish society of pediatric rheumatology for transition management from pediatric to adult care in rheumatic patients with childhood onset

Author

Calvo, Inmaculada, Antón, Jordi, Bustabad, Sagrario, Camacho, Marisol, de Inocencio, Jaime, Gamir, Mª Luz, Graña, Jenaro, La Cruz, Lucía, Robledillo, Juan Carlos López, Medrano, Marta, Merino, Rosa, Modesto, Consuelo, Nuñez, Esmeralda, Rua, Mª Jesús, Torrente-Segarra, Vicenç, Vargas, Carmen, Carmona, Loreto, and Loza, Estíbaliz

Published
2015
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55. Predictors of mental health service utilization as adolescents with attention deficit hyperactivity disorder transition into adulthood

Author

Girela‐Serrano, Braulio, primary, Miguélez, Carolina, additional, Porras‐Segovia, Alejandro Albán, additional, Díaz, Cristina, additional, Moreno, Manon, additional, Peñuelas‐Calvo, Inmaculada, additional, Roselló, Rocio, additional, Baca‐García, Enrique, additional, and Carballo, Juan José, additional

Published
2022
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57. Long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency: results from the randomised Phase 3 CLUSTER trial

Author

Immuno/reuma onderzoek 1 (Vastert), Child Health, Immuno/reuma onderzoek 5 (Vastert2), CTI Van Loosdregt, Infection & Immunity, Arts-assistenten Kinderen, Jeyaratnam, Jerold, Simon, Anna, Calvo, Inmaculada, Constantin, Tamas, Shcherbina, Anna, Hofer, Michael, Gattorno, Marco, Martini, Alberto, Bader-Meunier, Brigitte, Vastert, Bas, Levy, Jeremy, Dekker, Elise, de Benedetti, Fabrizio, Frenkel, Joost, Immuno/reuma onderzoek 1 (Vastert), Child Health, Immuno/reuma onderzoek 5 (Vastert2), CTI Van Loosdregt, Infection & Immunity, Arts-assistenten Kinderen, Jeyaratnam, Jerold, Simon, Anna, Calvo, Inmaculada, Constantin, Tamas, Shcherbina, Anna, Hofer, Michael, Gattorno, Marco, Martini, Alberto, Bader-Meunier, Brigitte, Vastert, Bas, Levy, Jeremy, Dekker, Elise, de Benedetti, Fabrizio, and Frenkel, Joost

Published
2022

58. OA37 Secukinumab treatment in children and adolescents with enthesitis-related arthritis and juvenile psoriatic arthritis: efficacy and safety results from a Phase 3 study

Author

Ramanan, Athimalaipet V, primary, Brunner, Hermine I, additional, Foeldvari, Ivan, additional, Alexeeva, Ekaterina, additional, Ayaz, Nuray A, additional, Calvo, Inmaculada, additional, Kasapcopur, Ozgur, additional, Chasnyk, Vyacheslav G, additional, Hufnagel, Markus, additional, Zuber, Zbigniew, additional, Schulert, Grant, additional, Ozen, Seza, additional, Popov, Artem, additional, Scott, Christiaan, additional, Sözeri, Betul, additional, Zholobova, Elena, additional, Zhu, Xuan, additional, Whelan, Sarah, additional, Pricop, Luminita, additional, Ravelli, Angelo, additional, Martini, Alberto, additional, Lovell, Daniel J, additional, and Ruperto, Nicolino, additional

Published
2022
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60. Actas de las IV Jornadas ScienCity 2021. Fomento de la Cultura Científica, Tecnológica y de Innovación en Ciudades Inteligentes

Author

Segura Bonilla, Olman, García Sánchez, Daniela, Mena Nieto, Ángel Isidro, Golpe Moya, Antonio Aníbal, Molina-Gómez, Jose Carlos, Mena-Gonzalez, Angel, Da Silva-Lima, Lucas, Martínez Luna, Macarena, García Vivas, Rocío, Segura Manzano, Francisca, Andújar Márquez, José Manuel, Morillo Reina, Juan Diego, Mateo Sanguino, Tomás Jesús, Pino Fernández, Joaquín del, Ruiz Castilla, Daniel, Millán Prior, Borja, Ceada Garrido, Yolanda, Ríos Gutiérrez, Juan, Barragán Piña, Antonio Javier, Enrique Gómez, Juan Manuel, Tejada Guzmán, Diego, Amaro, Jair, Gamero, José, Sánchez-Herguedas, Antonio, Rodrigo-Muñoz, Francisco, Villalba-Diez, Javier, Ordieres-Meré, Joaquín, Noguera, Miguel, Sayago Gómez, Ana, Fernández Recamales, María Ángeles, Felipe Pulido, Ángel, Gamero, Ulises, Mariano Rodríguez-Pérez, Ángel, Pulido Calvo, Inmaculada, Hernández-Garrido, Rocío, Perea El Khalifi, David, Pérez-Calañas, Cinta, Lozano Domínguez, José Manuel, Redondo González, Manuel Joaquín, Cortés Ancos, Estefanía, Santos, Carla, Dias, Cristina, Morón Monge, María del Carmen, Trabajo Rite, Mónica, and Vargas Sánchez, Alfonso

Subjects
Educación digital, Gobernanza, Industria 4.0, Medio ambiente, Seguridad, Sostenibilidad, Economía
Abstract

ScienCity es una actividad que viene siendo continuada desde 2018 con el objetivo de dar a conocer los conocimientos y tecnologías emergentes siendo investigados en las universidades, informar de experiencias, servicios e iniciativas puestas ya en marcha por instituciones y empresas, llegar hasta decisores políticos que podrían crear sinergias, incentivar la creación de ideas y posibilidades de desarrollo conjuntas, implicar y provocar la participación ciudadana, así como gestar una red internacional multidisciplinar de investigadores que garantice la continuación de futuras ediciones. ScienCity ha servido para que universidades, ayuntamientos, organismos públicos y empresas privadas tomen contacto por primera vez en este ámbito. Durante 2021 han asistido 40 participantes de distintos rincones de España, Portugal, Méjico, Costa Rica, Italia y Polonia con 31 ponencias, 8 pósteres, 1 taller, 8 vehículos eléctricos e híbridos, así como 8 propuestas para el concurso de ideas., Fundación Española para la Ciencia y la Tecnología-Ministerio de Ciencia, Innovación y Universidades; Consejería de la Presidencia, Administración Pública e Interior de la Junta de Andalucía; Estrategia de Política de Investigación y Transferencia de la Universidad de Huelva; Cátedra de Innovación Social de Aguas de Huelva; Cátedra de la Provincia Escuela Técnica Superior de Ingeniería; Grupo de investigación TEP-192 de Control y Robótica; Mercedes, BMW, Mini, Kia, Volvo y Tesla

Published
2022

61. Predictors of mental health service utilization as adolescents with attention deficit hyperactivity disorder transition into adulthood.

Author

Girela‐Serrano, Braulio, Miguélez, Carolina, Porras‐Segovia, Alejandro Albán, Díaz, Cristina, Moreno, Manon, Peñuelas‐Calvo, Inmaculada, Roselló, Rocio, Baca‐García, Enrique, and Carballo, Juan José

Subjects
ATTENTION-deficit hyperactivity disorder, MENTAL health services, TRANSITION to adulthood, YOUNG adults, TEENAGERS, ADOLESCENT health
Abstract

Background: Attention deficit hyperactivity disorder (ADHD) symptoms may persist into adulthood and are likely to cause great problems in young adults. To date, few studies have explored the characteristics of patients diagnosed with ADHD that might influence the utilization of adult mental health services (AMHS). We aimed to examine and identify predictive symptoms of AMHS. Methods: We analysed data from 114 participants diagnosed with ADHD from a cohort of adolescents recruited at the age of 12–17 years, who, at the time of data analysis, were over 18 years old. Results: Among AMHS users, hyperactivity/impulsivity measures were significantly more severe (t = 2.668, df = 112, p <.001), ADHD combined subtype diagnosis (χ2 = 4.66, df = 1, p =.031) was more frequent and dysregulation profile in the SDQ‐P was also significantly higher (t = −2.497, df = 109, p =.014). However, the dysregulation profile did not remain statistically significant after controlling for type of AMHS contact. Conclusions: Our findings suggest that adolescents with ADHD are more likely continue their care under AMHS if they present more severe symptoms of hyperactivity/impulsivity and emotional dysregulation. The better characterization of the patient profile will help clinicians to early identify groups at‐risk and to tailor interventions and prevention strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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62. American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus

Author

Brunner, Hermine I, Holland, Michael J, Beresford, Michael W, Ardoin, Stacy P, Appenzeller, Simone, Silva, Clovis A, Flores, Francisco, Goilav, Beatrice, Aydin, Pinar Ozge Avar, Wenderfer, Scott E, Levy, Deborah M, Ravelli, Angelo, Khubchandani, Raju, Avcin, Tadej, Klein-Gitelman, Marisa S, Ruperto, Nicolino, Feldman, Brian M, Ying, Jun, Battagliotti, Cristina, Brusco, Maria Isabel, Cuttica, Ruben, De Cunto, Carmen, Espada, Graciela, Farfan, Maximiliano, Garay, Stella, Marcantoni, Maria, Marcela, Alvarez, Meiorin, Silvia, Rama, Maria Elena, Russo, Ricardo, Walsh, Carolina Torre, Zamparo, Celso, Adib, Navid, Akikusa, Jonathan, Boros, Christina, Lee, Senq J, Mckay, Damien, Piper, Susan, Joos, Rik, Bica, Blanca, Campos, Leonardo, Cavalcanti, Andre, do Prado, Rogerio, Donner-Maliki, Amanda, Fernandes, Taciana, Fonseca, Adriana, de Almeida, Rozana Gasparello, Guariento, Andressa, Gusman, Catherine, Fiorot, Fernanda Jusan, Oliveira, Sheila Knupp, Len, Claudio, Campos, Lucia M Arruda, Machado, Sandra, Marques, Luciana, de Carvalho, Luciana Martins, Moulin, Rodrigo, Pedroso, Soraya, Pileggi, Gecilmara, Romanelli, Paulo Roberto S, Saad-Magalhaes, Claudia, Sakamoto, Ana, Santos, Maria Carolina, Silva, Marco Felipe, Spelling, Paulo, Sztajnbok, Flavio, Terreri, Maria, Cabral, David, Chedeville, Gaelle, Ellsworth, Janet, Huber, Adam, Tucker, Lori, Houghton, Kristin, Borzutzky, Arturo, Ladino, Mabel, Norambuena, Ximena, Eraso, Ruth, Mosquera, Angela, Velasquez, Monica, Harjacek, Miroslav, Jelusic, Marija, Hermosilla, Cecilia Coto, Dolezalova, Pavla, Nielsen, Susan, Tineo, Carmen, Alegria, Mauricio, Dressler, Frank, Foell, Dirk, Ganser, Gerd, Hinze, Claas, Hufnagel, Markus, Lutz, Thomas, Trauzeddel, Ralf, Boiu, Sorina, Trachana, Maria, Tsitsami, Elena, Cifuentes, Mayra, Orban, Ilonka, Aggarwal, Amita, Sawhney, Sujata, Aviel, Yonatan Butbul, Cimaz, Rolando, Maggio, Maria Cristina, Rumba-Rozenfelde, Ingrid, Hashad, Soad, Lim, Sern Chin, Abud, Carlos, Burgos-Vargas, Ruben, Carreno-Manjarrez, Roberto, Enciso Pelaez, Sandra, Hernandez-Huirache, Hayde, Maldonado Velazquez, Rocio, Orozco, Javier, Rodriguez-Lozano, Ana Luisa, Rojas Pacheco, Omar Ernesto, Suarez Larios, Luz Maria, Vega, Gabriel, Ramirez Miramontes, Julia Veronica, Ruiz Lopez, Ivon Karina, Kamphuis, Sylvia, Schonenberg-Meinema, Dieneke, Concannon, Anthony, Yan, Jaqueline, Jaime, Martha Jarquin, Al Abrawi, Safiya, Vega, Cynthia, Lopez-Benitez, Jorge, Estrella, Amparo Ibanez, Miraval, Tatiana, Dans, Leonia, Kimseng, Karen Joy, Opoka-Winiarska, Violetta, Rutkowska-Sak, Lidia, Smolewska, Elzbieta, Conde, Marta, Guedes, Margarida, del Valle, Enid, Quintero-Del Rio, Ana, Ailioaie, Constantin, Sparchez, Mihaela, Alekseeva, Ekaterina, Keltsev, Vladimir, Al-Mayouf, Sulaiman, Asiri, Abdurhman, Suwairi, Wafaa, Susic, Gordana, Vijatov-Djuric, Gordana, Ang, Elizabeth, Arkachaisri, Thaschawee, Boteanu, Alina-Lucica, Lopez-Robledillo, Juan Carlos, San Ildefonso, Marta Medrano, Modesto, Consuelo, Calvo, Inmaculada, Sotoca-Fernandez, Jorge, Bolt, Isabel, Vilaiyuk, Soamarat, Al-Abadi, Eslam, Baildam, Eileen, Fotis, Lampros, Pain, Clare, Pilkington, Clarissa, Abulaban, Khalid, Barbar-Smiley, Fatima, Binstadt, Bryce, Bohnsack, John, Boneparth, Alexis, Brown, Diane, Chira, Peter, Cron, Randy, Dedeoglu, Fatma, Eberhard, Anne, Gedalia, Abraham, Grom, Alexei, Henrickson, Michael, Hom, Christine, Huggins, Jennifer, Jerath, Rita, Jones, Jordan, Jung, Lawrence, Kingsbury, Daniel, Lai, Jamie, Lovell, Daniel, Nanda, Kabita, Nocton, James, Olson, Judyann, O'Neil, Kathleen, Onel, Karen, Punaro, Lynn, Reiff, Andreas, Rouster-Stevens, Kelly, Ruth, Natasha, Schikler, Ken, Schmidt, Kara Murphy, Schulert, Grant, Shaham, Bracha, Singer, Nora, Smith, Judith, Sundel, Robert, Syverson, Grant, Vega-Fernandez, Patricia, Vehe, Richard, Wagner-Weiner, Linda, Cameto, Juan, Jurado, Rosario, Maldonado, Irama, Org, Paediat Rheumatology Int Trial, Collaborative, Pediat Rheumatology, AII - Inflammatory diseases, Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, Brunner, Hermine I., Holland, Michael J., Beresford, Michael W., Ardoin, Stacy P., Appenzeller, Simone, Silva, Clovis A., Flores, Francisco, Goilav, Beatrice, Avar Aydin, Pinar Ozge, Wenderfer, Scott E., Levy, Deborah M., Ravelli, Angelo, Khubchandani, Raju, Avcin, Tadej, Klein-Gitelman, Marisa S., Ruperto, Nicolino, Feldman, Brian M., Ying, Jun, Battagliotti, Cristina, Brusco, Maria Isabel, Cuttica, Rubén, De Cunto, Carmen, Espada, Graciela, Farfan, Maximiliano, Garay, Stella, Marcantoni, Maria, Marcela, Alvarez, Meiorin, Silvia, Rama, Maria Elena, Russo, Ricardo, Torre Walsh, Carolina, Zamparo, Celso, Adib, Navid, Akikusa, Jonathan, Boros, Christina, Lee, Senq J., Mckay, Damien, Piper, Susan, Joos, Rik, Bica, Blanca, Campos, Leonardo, Cavalcanti, André, do Prado, Rogerio, Donner-Maliki, Amanda, Fernandes, Taciana, Fonseca, Adriana, Gasparello de Almeida, Rozana, Guariento, Andressa, Gusman, Catherine, Jusan Fiorot, Fernanda, Knupp Oliveira, Sheila, Len, Claudio, Arruda Campos, Lucia M., Machado, Sandra, Marques, Luciana, Martins de Carvalho, Luciana, Moulin, Rodrigo, Pedroso, Soraya, Pileggi, Gecilmara, Romanelli, Paulo Roberto S., Saad-Magalhaes, Claudia, Sakamoto, Ana, Santos, Maria Carolina, Silva, Marco Felipe, Spelling, Paulo, Sztajnbok, Slavio, Terreri, Maria, Cabral, David, Chédeville, Gaëlle, Ellsworth, Janet, Huber, Adam, Tucker, Lori, Houghton, Kristin, Borzutzky, Arturo, Ladino, Mabel, Norambuena, Ximena, Eraso, Ruth, Mosquera, Angela, Velasquez, Monica, Harjacek, Miroslav, Jelusic, Marija, Coto Hermosilla, Cecilia, Dolezalova, Pavla, Nielsen, Susan, Tineo, Carmen, Alegria, Mauricio, Dressler, Frank, Foell, Dirk, Ganser, Gerd, Hinze, Claa, Hufnagel, Marku, Lutz, Thoma, Trauzeddel, Ralf, Boiu, Sorina, Trachana, Maria, Tsitsami, Elena, Cifuentes, Mayra, Orbán, Ilonka, Aggarwal, Amita, Sawhney, Sujata, Butbul Aviel, Yonatan, Cimaz, Rolando, Maggio, Maria Cristina, Rumba-Rozenfelde, Ingrid, Hashad, Soad, Lim, Sern Chin, Abud, Carlo, Burgos-Vargas, Ruben, Carreño-Manjarrez, Roberto, Enciso Pelaez, Sandra, Hernandez-Huirache, Hayde, Maldonado Velázquez, Rocio, Orozco, Javier, Rodriguez-Lozano, Ana Luisa, Rojas Pacheco, Omar Ernesto, Suárez Larios, Luz Maria, Vega, Gabriel, Ramírez Miramontes, Julia Verónica, Ruíz Lopez, Ivon Karina, Kamphuis, Sylvia, Schonenberg-Meinema, Dieneke, Concannon, Anthony, Yan, Jaqueline, Jarquin Jaime, Martha, Al Abrawi, Safiya, Vega, Cynthia, Lopez-Benitez, Jorge, Ibáñez Estrella, Amparo, Miraval, Tatiana, Dans, Leonia, Kimseng, Karen Joy, Opoka-Winiarska, Violetta, Rutkowska-Sak, Lidia, Smolewska, Elzbieta, Conde, Marta, Guedes, Margarida, del Valle, Enid, Quintero-Del Rio, Ana, Ailioaie, Constantin, Sparchez, Mihaela, Alekseeva, Ekaterina, Keltsev, Vladimir, Al-Mayouf, Sulaiman, Asiri, Abdurhman, Suwairi, Wafaa, Susic, Gordana, Vijatov-Djuric, Gordana, Ang, Elizabeth, Arkachaisri, Thaschawee, Boteanu, Alina-Lucica, Lopez-Robledillo, Juan Carlo, Medrano San Ildefonso, Marta, Modesto, Consuelo, Calvo, Inmaculada, Sotoca-Fernandez, Jorge, Bolt, Isabel, Vilaiyuk, Soamarat, Al-Abadi, Eslam, Baildam, Eileen, Fotis, Lampro, Pain, Clare, Pilkington, Clarissa, Abulaban, Khalid, Barbar-Smiley, Fatima, Binstadt, Bryce, Bohnsack, John, Boneparth, Alexi, Brown, Diane, Chira, Peter, Cron, Randy, Dedeoglu, Fatma, Eberhard, Anne, Gedalia, Abraham, Grom, Alexei, Henrickson, Michael, Hom, Christine, Huggins, Jennifer, Jerath, Rita, Jones, Jordan, Jung, Lawrence, Kingsbury, Daniel, Lai, Jamie, Lovell, Daniel, Nanda, Kabita, Nocton, Jame, Olson, Judyann, O’Neil, Kathleen, Onel, Karen, Punaro, Lynn, Reiff, Andrea, Rouster-Stevens, Kelly, Ruth, Natasha, Schikler, Ken, Murphy Schmidt, Kara, Schulert, Grant, Shaham, Bracha, Singer, Nora, Smith, Judith, Sundel, Robert, Syverson, Grant, Vega-Fernandez, Patricia, Vehe, Richard, Wagner-Weiner, Linda, Cameto, Juan, Jurado, Rosario, Maldonado, Irama, and Pediatrics

Subjects
medicine.medical_specialty, Outcome Assessment, Health Care/methods, Adolescent, Delphi Technique, Antirheumatic Agents/therapeutic use, Severity of Illness Index, Child health, Article, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, Severity of illness, Outcome Assessment, Health Care, medicine, Pediatric nephrology, Humans, Lupus Erythematosus, Systemic, skin and connective tissue diseases, Child, 030203 arthritis & rheumatology, Systemic lupus erythematosus, Lupus erythematosus, Lupus Erythematosus, Receiver operating characteristic, business.industry, Consensus conference, childhood-onset systemic lupus erythematosus, Outcome Assessment, Health Care/methods, medicine.disease, Rheumatology,Systemic lupus erythematosus,autoimmune inflammatory disease, Antirheumatic Agents, Lupus Erythematosus, Systemic/drug therapy, Systemic/drug therapy, business, Algorithms
Abstract

OBJECTIVE: To develop a Childhood Lupus Improvement Index (CHILI) as a tool to measure response to therapy in childhood-onset systemic lupus erythematosus (cSLE), with a focus on clinically relevant improvement (CRIc SLE ). METHODS: Pediatric nephrology and rheumatology subspecialists (n = 213) experienced in cSLE management were invited to define CRIc SLE and rate a total of 433 unique patient profiles for the presence/absence of CRIc SLE . Patient profiles included the following cSLE core response variables (CRVs): global assessment of patient well-being (patient-global), physician assessment of cSLE activity (MD-global), disease activity index score (here, we used the Systemic Lupus Erythematosus Disease Activity Index), urine protein-to-creatinine ratio, and Child Health Questionnaire physical summary score. Percentage and absolute changes in these cSLE- CRVs (baseline versus follow-up) were considered in order to develop candidate algorithms and validate their performance (sensitivity, specificity, area under the receiver operating characteristic curve [AUC] ; range 0-1). RESULTS: During an international consensus conference, unanimous agreement on a definition of CRIc SLE was achieved ; cSLE experts (n = 13) concurred (100%) that the preferred CHILI algorithm considers absolute changes in the cSLE- CRVs. After transformation to a range of 0-100, a CHILI score of ≥54 had outstanding accuracy for identifying CRIc SLE (AUC 0.93, sensitivity 81.1%, and specificity 84.2%). CHILI scores also reflect minor, moderate, and major improvement for values exceeding 15, 68, and 92, respectively (all AUC ≥0.92, sensitivity ≥93.1%, and specificity ≥73.4%). CONCLUSION: The CHILI is a new, seemingly highly accurate index for measuring CRI in cSLE over time. This index is useful to categorize the degree of response to therapy in children and adolescents with cSLE.

Published
2019

66. Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab

Author

Grom, Alexei A., Ilowite, Norman T., Pascual, Virginia, Brunner, Hermine I., Martini, Alberto, Lovell, Daniel, Ruperto, Nicolino, Leon, Karolynn, Lheritier, Karine, Abrams, Ken, Cuttica, Ruben, Emminger, Wolfgang, Goffin, Laurence, Joos, Rik, Lauwerys, Bernard, Wouters, Carine, Hilário, Maria Odete Esteves, de Oliveira, Sheila Knupp Feitosa, Len, Claudio, Radominski, Sebastiao, Sztajnbok, Flavio Roberto, Haddad, Elie, Hofer, Michael, Houghton, Kristin, Huber, Adam, Saurenmann, Traudel, Schneider, Rayfel, Tucker, Lori, Bader-Meunier, Brigitte, Desjonqueres, Marine, Fischbach, Michel, Kone-Paut, Isabelle, Marie, Isabelle, Mogenet, Agnes, Mouy, Richard, Quartier, Pierre, Berner, Reinhard, Foeldvari, Ivan, Foell, Dirk, Frosch, Michael, Haas, Johannes-Peter, Horneff, Gerd, Hufnagel, Markus, Kallinich, Tilmann, Kuemmerle-Deschner, Jasmin, Lehmann, Hartwig, Lutz, Thomas, Thon, Angelika, Trauzeddel, Ralf, Tzaribachev, Nikolay, Weibarth-Riedel, Elisabeth, Chrousos, Georgios, Trachana, Maria, Vougiouka, Olga, Constantin, Tamas, Barash, Judith, Berkun, Yackov, Brik, Riva, Harel, Liora, Nahum, Amit, Pade, Shay, Uziel, Yosef, Alessio, Maria, Cimaz, Rolando, Corona, Fabrizia, Gerloni, Valeria, Wulffraat, N. M., Ferrandiz, Manuel, Rutkowska-Sak, Lidia, Alekseeva, Ekaterina, Chasnyk, Vyacheslav, Nasonov, Evgeny, Stanislav, Marina, Anton, Jordi, Calvo, Inmaculada, Gamir, Mari Luz, Robledillos, Juan Carlos, Magnusson, Bo, Erguven, Muferet, Kasapcopur, Ozgur, Ozdogan, Huri, Ozen, Seza, Unsal, Erbil, Chieng, Alice, Foster, Helen, McCann, Liza, Ramanan, Athimalaip, Southwood, Taunton, Wilkinson, Nicholas, Woo, Patricia, Higgins, Gloria Christine, Kingsbury, Daniel, Lopez-Benitez, Jorge, Marzan, Katherine, Morris, Paula, Natter, Marc, and Schikler, Kenneth Noel

Published
2016
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68. Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial

Author

Brunner, Hermine I, Ruperto, Nicolino, Zuber, Zbigniew, Keane, Caroline, Harari, Olivier, Kenwright, Andrew, Lu, Peng, Cuttica, Ruben, Keltsev, Vladimir, Xavier, Ricardo M, Calvo, Inmaculada, Nikishina, Irina, Rubio-Pérez, Nadina, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Horneff, Gerd, Opoka-Winiarska, Violetta, Quartier, Pierre, Silva, Clovis A, Silverman, Earl, Spindler, Alberto, Baildam, Eileen, Gámir, M Luz, Martin, Alan, Rietschel, Christoph, Siri, Daniel, Smolewska, Elzbieta, Lovell, Daniel, Martini, Alberto, De Benedetti, Fabrizio, Espada, Graciela, Allen, Roger, Chaitow, Jeffrey, Joos, Rik, Wouters, Carine, Knupp, Sheila, Sztajnbok, Flavio, Cabral, David, Houghton, Kristin, Roth, Johannes, Schmeling, Heinrike, Job-Deslandre, Chantal, Jorgensen, Christian, Paut, Isabelle Kone, Minden, Kirsten, Weller-Heinemann, Frank, Gerloni, Valeria, Zulian, Francesco, Burgos-Vargas, Ruben, Salazar, Carolina Duarte, Solis-Vallejo, Eunice, Calvo, Armando, Chavez, José, Zavaler, Manuel Ferrandiz, Gruenpeter, Anna, Kobusinska, Katarzyna, Sarychev, Alexey, Zholobova, Elena, Ramanan, Athimalaipet, Woo, Patricia, Goodman, Steven, Gedalia, Abraham, Kimura, Yukiko, Onel, Karen, and Schikler, Kenneth

Published
2015
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69. Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes

Author

Nakagawa, Kenji, Gonzalez-Roca, Eva, Souto, Alejandro, Kawai, Toshinao, Umebayashi, Hiroaki, Campistol, Josep María, Cañellas, Jeronima, Takei, Syuji, Kobayashi, Norimoto, Callejas-Rubio, Jose Luis, Ortego-Centeno, Norberto, Ruiz-Ortiz, Estíbaliz, Rius, Fina, Anton, Jordi, Iglesias, Estibaliz, Jimenez-Treviño, Santiago, Vargas, Carmen, Fernandez-Martin, Julian, Calvo, Inmaculada, Hernández-Rodríguez, José, Mendez, María, Dordal, María Teresa, Basagaña, Maria, Bujan, Segundo, Yashiro, Masato, Kubota, Tetsuo, Koike, Ryuji, Akuta, Naoko, Shimoyama, Kumiko, Iwata, Naomi, Saito, Megumu K, Ohara, Osamu, Kambe, Naotomo, Yasumi, Takahiro, Izawa, Kazushi, Kawai, Tomoki, Heike, Toshio, Yagüe, Jordi, Nishikomori, Ryuta, and Aróstegui, Juan I

Published
2015
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72. Long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency: results from the randomised Phase 3 CLUSTER trial

Author

Jeyaratnam, Jerold, primary, Simon, Anna, additional, Calvo, Inmaculada, additional, Constantin, Tamas, additional, Shcherbina, Anna, additional, Hofer, Michael, additional, Gattorno, Marco, additional, Martini, Alberto, additional, Bader-Meunier, Brigitte, additional, Vastert, Bas, additional, Levy, Jeremy, additional, Dekker, Elise, additional, de Benedetti, Fabrizio, additional, and Frenkel, Joost, additional

Published
2021
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73. Ventricular Repolarization Parameters and Coronary Involvement in Kawasaki Disease

Author

Barrios-Tascón, Ana, primary, Miura, Masaru, additional, Domínguez-Rodríguez, Sara, additional, Fernández-Cooke, Elisa, additional, Sarquella-Brugada, Georgia, additional, Tagarro, Alfredo, additional, Fernandez-Cooke, Elisa, additional, Calvo, Cristina, additional, Sánchez-Manubens, Judith, additional, Antón, Jordi, additional, Santos, Javier Aracil, additional, Cuadros, Esmeralda Nuñez, additional, Navarro Gómez, Maria Luisa, additional, Pérez, David Moreno, additional, Cantero Pérez, María Martín, additional, Cuadros Pérez, Esmeralda Nuñez, additional, Gallego Pérez, Begoña Carazo, additional, García, Fernando Sánchez, additional, Lovillo, Marisol Camacho, additional, Marqués, Renata, additional, Laura, Olaf Neth, additional, Silveira, Fernández, additional, Forte, Miguel Sánchez, additional, Montes, Ángeles Ortega, additional, Martínez Campos, Leticia Isabel, additional, Mancheño, Beatriz Bravo, additional, Camacho, Margarita, additional, Medina Claros, Antonio F., additional, Salido, Carlos, additional, Rico, María Torres, additional, Saez, Beatriz Ruiz, additional, de la Puebla Lechuga, Elena Fernadez, additional, Cruz, Ma José Lirola, additional, Carrasco, Kety Maya, additional, González, Moisés Rodríguez, additional, Jover, Enrique Blanca, additional, Fernández, José Uberos, additional, Ibáñez Alcalde, María Mercedes, additional, Hidalgo, Miguel Lafuente, additional, Montañés, Lorenzo Jiménez, additional, Alonso, Matilde Bustillo, additional, Casas, Ariadna Ayerza, additional, Zapico, Bárbara Montes, additional, Méndez, Carlos Pérez, additional, Aracama, Javier Fernández, additional, Rodríguez, Lucía, additional, Ibáñez Fernández, María Aleida, additional, Campo, Sandra Navarro, additional, Bori, Silvia Escribà, additional, Mir Perelló, María Concepción, additional, Sánchez, Ma Ángeles de la Fuente, additional, García, Patricia Aparicio, additional, Briales, Carlos, additional, Crespí, Joaquín Castilla, additional, Colino Gil, María Elena, additional, Cabrera, Nerea Delgado, additional, Naranjo, Ana Bello, additional, Páez, Jesús Poch, additional, Yáñez, Moneyba García, additional, García, Montse González, additional, Viadero, Maite, additional, Montero, Beatriz Jiménez, additional, García, Olga Domínguez, additional, Pinedo, Begoña Losada, additional, Martín, Gema Iñigo, additional, Escribano Gómez, Lucía María, additional, Cepillo, Antonio, additional, Lillo, Miguel Lillo, additional, Buedo, María Isabel, additional, Rey, Laura del, additional, Rodríguez, Elena Urbaneja, additional, Rodríguez, Sara Rellán, additional, Cantero, Teresa, additional, Izquierdo, Beatriz Plata, additional, García-Cuenllas Álvarez, Luisa, additional, Erroz, Ignacio Oulego, additional, Santaolalla, Elena Pérez, additional, Martín, Carlos Alcalde, additional, Malfaz, Fernando Centeno, additional, Gutiérrez, Elena Pérez, additional, Casso, Ma Soledad Jiménez, additional, Prada, Fredy, additional, Bou, Rosa, additional, Iglesias, Estibaliz, additional, Calzada, Joan, additional, Garsaball, Olga Calavia, additional, Rue, Marc Tobeña, additional, García, Gemma Giralt, additional, Lobato, Zulema, additional, Gordillo, Neus Rius, additional, Torres, Montserrat Pascual, additional, Hernández, María Méndez, additional, García, Lourdes, additional, Villar, Sergio Flores, additional, Ruiz, Silvia Yevenes, additional, Domingo, Laura Minguell, additional, Ballester, Anna, additional, Miralles, Ana, additional, Soler, Berta Pujol, additional, Vidal, Anton Foguet, additional, Castellví, Pere Sala, additional, Aguiar, Angelita Serrano, additional, Siurana Rodríguez, José Manuel, additional, Iranzo, Anna Sangorrin, additional, Pérez, Roser Álvarez, additional, Cajas, Paula Ribes, additional, Genaró i Jornet, Pere, additional, Tejada, Ana Grande, additional, Zarallo, Cristina, additional, Martinón-Torres, Federico, additional, Calle, Irene Rivero, additional, Grande, Antonio Justicia, additional, Sousa, María López, additional, Vilas, Alejandro Souto, additional, Abel, Bernardo López, additional, de Miguel Esteban, Elisa, additional, Méndez, Bibiana Riaño, additional, Blázquez, Daniel, additional, Conejo, Pablo Rojo, additional, Lozano, Carlos Grasa, additional, Toral, Belén, additional, De la Torre, Leticia Albert, additional, de Inocencio, Jaime, additional, Santos, Mar, additional, Díaz-Delgado de la Peña, Rafael, additional, Ramos, Paz Collado, additional, Raga, Teresa, additional, Latorre, Libertad, additional, Guillén, Sara, additional, Caballero, Ignacio Callejas, additional, Prieto Tato, Luis Manuel, additional, Guzmán Monagas, María Fernanda, additional, López, Isabel Jiménez, additional, Villagrá, Sandra, additional, Arreo, Viviana, additional, Pérez, Roi Piñeiro, additional, Parte, María de la, additional, Tamariz-Martes, Amalia, additional, Romano, Marta Llorente, additional, Hernández Rupérez, Maria Belén, additional, Sombrero, Henar Rojo, additional, Cerro, Estefanía García, additional, Cano, Irene Maté, additional, Alonso, Marta Villares, additional, Osuna Marco, Marta Pilar, additional, Veron, Julia Jensen, additional, Reales, Cristina Zarallo, additional, Rodríguez Mesa, María Dolores, additional, Esteban, Santiago Rueda, additional, Ramos Amador, José Tomás, additional, Menchén, Cristina González, additional, Jiménez Jiménez, Ana Belén, additional, Galán, Pilar, additional, Campos, Dolores Pérez, additional, Bueno, Ma Mercedes, additional, Marcos, David Crespo, additional, Otheo de Tejada Barásoain, Enrique, additional, Sifuentes Giraldo, Walter Alberto, additional, Gámir Gámir, María Luz, additional, José Cilleruelo Ortega, María, additional, López, Agustín López, additional, Vaquerizo, Cristina Sánchez, additional, Usano Carrasco, Ana Isabel, additional, Gómez, Ester Moreno, additional, Carvajal del Castillo, Olga, additional, Del Pozo Menéndez, Beatriz, additional, Navarro, Katie Badillo, additional, Baquero, Fernando, additional, Bronte, Lucía Deiros, additional, Fraga, Pablo Fernández, additional, Domínguez, Nieves, additional, Rodríguez, Beatriz Mercader, additional, García, Francisco Castro, additional, Chamorro, Águeda Herrera, additional, Rodríguez, Paula Alcañiz, additional, García, Moisés Sorlí, additional, Rex Nicolás, María Concepción, additional, Romero, Elena Vera, additional, Olorón, Patricia Martínez, additional, Cilveti, Beatriz Rocandio, additional, Berridi, Amaia, additional, Santos-Díez Vázquez, Laura, additional, Fernández, Olaia, additional, Calvo, Inmaculada, additional, Tudela, Belén Fernández, additional, Benavent, Manuel Oltra, additional, Archilés, Marta Dapena, additional, Ferrer, Franciasco Sanchez, additional, Gavilán, César, additional, Fos, Ignacio Izquierdo, additional, Serrano Robles, María Isabel, additional, Sánchez, Yolanda Herranz, additional, Pinto, Enrique Villalobos, additional, Garulo, Daniel Clemente, additional, Pie, Stella, additional, Calvo, Manuel Marrero, additional, and Olmos García, José María, additional

Published
2021
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89. Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis

Author

Ruperto, Nicolino, Brunner, Hermine I., Quartier, Pierre, Constantin, Tamás, Wulffraat, Nico, Horneff, Gerd, Brik, Riva, McCann, Liza, Kasapcopur, Ozgur, Rutkowska-Sak, Lidia, Schneider, Rayfel, Berkun, Yackov, Calvo, Inmaculada, Erguven, Muferet, Goffin, Laurence, Hofer, Michael, Kallinich, Tilmann, Oliveira, Sheila K., Uziel, Yosef, Viola, Stefania, Nistala, Kiran, Wouters, Carine, Cimaz, Rolando, Ferrandiz, Manuel A., Flato, Berit, Gamir, Maria Luz, Kone-Paut, Isabelle, Grom, Alexei, Magnusson, Bo, Ozen, Seza, Sztajnbok, Flavio, Lheritier, Karine, Abrams, Ken, Kim, Dennis, Martini, Alberto, and Lovell, Daniel J.

Published
2012
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90. Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis

Author

De Benedetti, Fabrizio, Brunner, Hermine I., Ruperto, Nicolino, Kenwright, Andrew, Wright, Stephen, Calvo, Inmaculada, Cuttica, Ruben, Ravelli, Angelo, Schneider, Rayfel, Woo, Patricia, Wouters, Carine, Xavier, Ricardo, Zemel, Lawrence, Baildam, Eileen, Burgos-Vargas, Ruben, Dolezalova, Pavla, Garay, Stella M., Merino, Rosa, Joos, Rik, Grom, Alexei, Wulffraat, Nico, Zuber, Zbigniew, Zulian, Francesco, Lovell, Daniel, and Martini, Alberto

Published
2012
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93. GenotypeFBN1/phenotype relationship in a cohort of patients with Marfan syndrome

Author

Hernándiz, Amparo, primary, Zúñiga, Angel, additional, Valera, Francisco, additional, Domingo, Diana, additional, Ontoria‐Oviedo, Imelda, additional, Marí, Jose F., additional, Román, Jose A., additional, Calvo, Inmaculada, additional, Insa, Beatriz, additional, Gómez, Rosa, additional, Cervera, José V., additional, Miralles, Manuel, additional, Montero, Jose A., additional, Martínez‐Dolz, Luis, additional, and Sepúlveda, Pilar, additional

Published
2020
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100. Long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency: results from the randomised Phase 3 CLUSTER trial.

Author

Jeyaratnam, Jerold, Simon, Anna, Calvo, Inmaculada, Constantin, Tamas, Shcherbina, Anna, Hofer, Michael, Gattorno, Marco, Martini, Alberto, Bader-Meunier, Brigitte, Vastert, Bas, Levy, Jeremy, Dekker, Elise, Benedetti, Fabrizio de, and Frenkel, Joost

Subjects
THERAPEUTIC use of monoclonal antibodies, DRUG efficacy, C-reactive protein, ACUTE phase proteins, MONOCLONAL antibodies, INTERLEUKIN-1, MEVALONATE kinase deficiency, RANDOMIZED controlled trials, DESCRIPTIVE statistics, PATIENT safety, AUTOINFLAMMATORY diseases, EVALUATION
Abstract

Objectives To evaluate the long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency during the open label extension (weeks 41–113) of the randomized controlled CLUSTER trial. Methods During a 72-week period, patients received open-label canakinumab 150 or 300 mg, every 4 or 8 weeks. The disease activity was evaluated every 8 weeks using physician global assessment and counting the number of flares. Concentrations of CRP and serum amyloid A protein were measured. The safety was studied by determination and classification of observed adverse events. The safety and efficacy were analysed separately in three subgroups of patients receiving a cumulative dose of less than <35 mg/kg, ≥35 to <70 mg/kg or ≥70 mg/kg. Results Of the 74 patients who started the CLUSTER study, 66 entered Epoch 4 and 65 completed it. During the 72-week period, 42 (64%) patients experienced no flares, while 13 (20%) had one flare, as compared with a median of 12 flares per year reported at baseline. Low physician global assessment scores were seen at the end of the study for all groups with >90% reporting minimal disease activity or none at all. Median CRP concentrations were consistently equal or lower than 10 mg/l, while median serum amyloid A concentrations remained only slightly above the normal range of 10 mg/l. The study showed no new or unexpected adverse events. Conclusion Canakinumab proved effective to control disease activity and prevent flares in mevalonate kinase deficiency during the 72-week study period. No new safety concerns were reported. Trial registration NCT02059291. https://clinicaltrials.gov. [ABSTRACT FROM AUTHOR]

Published
2022
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