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51. Prognostic significance of calcified plaque among symptomatic patients with nonobstructive coronary artery disease

Author

Shah, Sana, Bellam, Naveen, Leipsic, Jonathon, Berman, Daniel S, Quyyumi, Arshed, Hausleiter, Jörg, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Fillippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chow, Benjamin JW, Cury, Ricardo C, Delago, Augustin J, Dunning, Allison L, Feuchtner, Gudrun M, Hadamitzky, Martin, Karlsberg, Ronald P, Kaufmann, Philipp A, Lin, Fay Y, Chinnaiyan, Kavitha M, Maffei, Erica, Raff, Gilbert L, Villines, Todd C, Gomez, Millie J, Min, James K, Shaw, Leslee J, and for the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry) Investigators

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Clinical Research, Heart Disease, Heart Disease - Coronary Heart Disease, Atherosclerosis, Prevention, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Adult, Age Distribution, Aged, Aged, 80 and over, Animals, Cats, Causality, Comorbidity, Coronary Stenosis, Female, Humans, Internationality, Male, Middle Aged, Prevalence, Prognosis, Proportional Hazards Models, Radionuclide Imaging, Registries, Reproducibility of Results, Risk Assessment, Sensitivity and Specificity, Sex Distribution, Survival Rate, Symptom Assessment, Vascular Calcification, Coronary calcification, prognosis, nonobstructive coronary artery disease, CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry) Investigators, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundCoronary artery calcium (CAC) is a well-established predictor of clinical outcomes for population screening. Limited evidence is available as to its predictive value in symptomatic patients without obstructive coronary artery disease (CAD). The aim of the current study was to assess the prognostic value of CAC scores among symptomatic patients with nonobstructive CAD.MethodsFrom the COronary Computed Tomographic Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 7,200 symptomatic patients with nonobstructive CAD (0% but

Published
2014

52. Age-related risk of major adverse cardiac event risk and coronary artery disease extent and severity by coronary CT angiography: results from 15 187 patients from the International Multisite CONFIRM Study

Author

Nakazato, Ryo, Arsanjani, Reza, Achenbach, Stephan, Gransar, Heidi, Cheng, Victor Y, Dunning, Allison, Lin, Fay Y, Al-Mallah, Mouaz, Budoff, Matthew J, Callister, Tracy Q, Chang, Hyuk-Jae, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin JW, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Raff, Gilbert, Shaw, Leslee J, Villines, Todd, Cury, Ricardo C, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Berman, Daniel S, and Min, James K

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Heart Disease - Coronary Heart Disease, Biomedical Imaging, Patient Safety, Heart Disease, Atherosclerosis, Cardiovascular, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Age Factors, Coronary Angiography, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Radiographic Image Interpretation, Computer-Assisted, Risk Assessment, Risk Factors, Severity of Illness Index, Tomography, X-Ray Computed, Age, Major adverse cardiac events, Coronary artery disease, coronary CT angiography, Cardiovascular medicine and haematology
Abstract

AimsPrior studies evaluating the prognostic utility of cardiac CT angiography (CCTA) have been largely constrained to an all-cause mortality endpoint, with other cardiac endpoints generally not reported. To this end, we sought to determine the relationship of extent and severity of coronary artery disease (CAD) by CCTA to risk of incident major adverse cardiac events (MACEs) (defined as death, myocardial infarction, and late revascularization).Methods and resultsWe identified subjects without prior known CAD who underwent CCTA and were followed for MACE. CAD by CCTA was defined as none (0% luminal stenosis), mild (1-49% luminal stenosis), moderate (50-69% luminal stenosis), or severe (≥70% luminal stenosis), and ≥50% luminal stenosis was considered as obstructive. CAD severity was judged on per-patient, per-vessel, and per-segment basis. Time to MACE was estimated using univariable and multivariable Cox proportional hazards models. Among 15 187 patients (57 ± 12 years, 55% male), 595 MACE events (3.9%) occurred at a 2.4 ± 1.2 year follow-up. In multivariable analyses, an increased risk of MACE was observed for both non-obstructive [hazard ratio (HR) 2.43, P < 0.001] and obstructive CAD (HR: 11.21, P < 0.001) when compared with patients with normal CCTA. Risk-adjusted MACE increased in a dose-response relationship based on the number of vessels with obstructive CAD ≥50%, with increasing hazards observed for non-obstructive (HR: 2.54, P < 0.001), obstructive one-vessel (HR: 9.15, P < 0.001), two-vessel (HR: 15.00, P < 0.001), or three-vessel or left main (HR: 24.53, P < 0.001) CAD. Among patients stratified by age

Published
2014

54. Incremental prognostic value of coronary computed tomographic angiography over coronary artery calcium score for risk prediction of major adverse cardiac events in asymptomatic diabetic individuals

Author

Min, James K, Labounty, Troy M, Gomez, Millie J, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha M, Chow, Benjamin, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jorg, Kaufmann, Philipp, Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, and Berman, Daniel S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Atherosclerosis, Heart Disease, Cardiovascular, Prevention, Heart Disease - Coronary Heart Disease, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Aged, Calcium, Constriction, Pathologic, Coronary Angiography, Coronary Vessels, Diabetes Complications, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Myocardial Infarction, Myocardial Revascularization, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Prospective Studies, Registries, Risk Factors, Surveys and Questionnaires, Tomography, X-Ray Computed, Coronary artery disease, Major adverse cardiac events, Coronary CT angiography, Coronary artery calcium score, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundCoronary artery disease (CAD) diagnosis by coronary computed tomographic angiography (CCTA) is useful for identification of symptomatic diabetic individuals at heightened risk for death. Whether CCTA-detected CAD enables improved risk assessment of asymptomatic diabetic individuals beyond clinical risk factors and coronary artery calcium scoring (CACS) remains unexplored.MethodsFrom a prospective 12-center international registry of 27,125 individuals undergoing CCTA, we identified 400 asymptomatic diabetic individuals without known CAD. Coronary stenosis by CCTA was graded as 0%, 1-49%, 50-69%, and ≥70%. CAD was judged on a per-patient, per-vessel and per-segment basis as maximal stenosis severity, number of vessels with ≥50% stenosis, and coronary segments weighted for stenosis severity (segment stenosis score), respectively. We assessed major adverse cardiovascular events (MACE) - inclusive of mortality, nonfatal myocardial infarction (MI), and late target vessel revascularization ≥90 days (REV) - and evaluated the incremental utility of CCTA for risk prediction, discrimination and reclassification.ResultsMean age was 60.4 ± 9.9 years; 65.0% were male. At a mean follow-up 2.4 ± 1.1 years, 33 MACE occurred (13 deaths, 8 MI, 12 REV) [8.25%; annualized rate 3.4%]. By univariate analysis, per-patient maximal stenosis [hazards ratio (HR) 2.24 per stenosis grade, 95% confidence interval (CI) 1.61-3.10, p < 0.001], increasing numbers of obstructive vessels (HR 2.30 per vessel, 95% CI 1.75-3.03, p < 0.001) and segment stenosis score (HR 1.14 per segment, 95% CI 1.09-1.19, p < 0.001) were associated with increased MACE. After adjustment for CAD risk factors and CACS, maximal stenosis (HR 1.80 per grade, 95% CI 1.18-2.75, p = 0.006), number of obstructive vessels (HR 1.85 per vessel, 95% CI 1.29-2.65, p < 0.001) and segment stenosis score (HR 1.11 per segment, 95% CI 1.05-1.18, p < 0.001) were associated with increased risk of MACE. Beyond age, gender and CACS (C-index 0.64), CCTA improved discrimination by maximal stenosis, number of obstructive vessels and segment stenosis score (C-index 0.77, 0.77 and 0.78, respectively). Similarly, CCTA findings improved risk reclassification by per-patient maximal stenosis [integrated discrimination improvement (IDI) index 0.03, p = 0.03] and number of obstructive vessels (IDI index 0.06, p = 0.002), and by trend for segment stenosis score (IDI 0.03, p = 0.06).ConclusionFor asymptomatic diabetic individuals, CCTA measures of CAD severity confer incremental risk prediction, discrimination and reclassification on a per-patient, per-vessel and per-segment basis.

Published
2014

55. Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry

Author

Rana, Jamal S, Dunning, Allison, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor Y, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo, Delago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jörg, Kaufmann, Philipp, Karlsberg, Ronald P, Kim, Yong-Jin, Leipsic, Jonathon, Labounty, Troy M, Lin, Fay Y, Maffei, Erica, Raff, Gilbert, Villines, Todd C, Shaw, Leslee J, Berman, Daniel S, and Min, James K

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Clinical Research, Heart Disease, Heart Disease - Coronary Heart Disease, Biomedical Imaging, Atherosclerosis, Prevention, Diabetes, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Aged, Coronary Angiography, Coronary Artery Disease, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Prevalence, Prognosis, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveWe examined the prevalence, extent, severity, and prognosis of coronary artery disease (CAD) in individuals with and without diabetes (DM) who are similar in CAD risk factors.Research design and methodsWe identified 23,643 consecutive individuals without known CAD undergoing coronary computed tomography angiography. A total of 3,370 DM individuals were propensity matched in a 1-to-2 fashion to 6,740 unique non-DM individuals. CAD was defined as none, nonobstructive (1-49% stenosis), or obstructive (≥ 50% stenosis). All-cause mortality was assessed by risk-adjusted Cox proportional hazards models.ResultsAt a 2.2-year follow-up, 108 (3.2%) and 115 (1.7%) deaths occurred among DM and non-DM individuals, respectively. Compared with non-DM individuals, DM individuals possessed higher rates of obstructive CAD (37 vs. 27%) and lower rates of having normal arteries (28 vs. 36%) (P < 0.0001). CAD extent was higher for DM versus non-DM individuals for obstructive one-vessel disease (19 vs. 14%), two-vessel disease (9 vs. 7%), and three-vessel disease (9 vs. 5%) (P < 0.0001 for comparison), with higher per-segment stenosis in the proximal and mid-segments of every coronary artery (P < 0.001 for all). Compared with non-DM individuals with no CAD, risk of mortality for DM individuals was higher for those with no CAD (hazard ratio 3.63 [95% CI 1.67-7.91]; P = 0.001), nonobstructive CAD (5.25 [2.56-10.8]; P < 0.001), one-vessel disease (6.39 [2.98-13.7]; P < 0.0001), two-vessel disease (12.33 [5.622-27.1]; P < 0.0001), and three-vessel disease (13.25 [6.15-28.6]; P < 0.0001).ConclusionsCompared with matched non-DM individuals, DM individuals possess higher prevalence, extent, and severity of CAD. At comparable levels of CAD, DM individuals experience higher risk of mortality compared with non-DM individuals.

Published
2012

56. Potential Implications of Coronary Artery Calcium Testing for Guiding Aspirin Use Among Asymptomatic Individuals With Diabetes

Author

Silverman, Michael Gordon, Blaha, Michael J, Budoff, Matthew J, Rivera, Juan J, Raggi, Paolo, Shaw, Leslee J, Berman, Daniel, Callister, Tracy, Rumberger, John A, Rana, Jamal S, Blumenthal, Roger S, and Nasir, Khurram

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Atherosclerosis, Diabetes, Heart Disease - Coronary Heart Disease, Cardiovascular, Prevention, Health Services, Heart Disease, Clinical Research, 4.2 Evaluation of markers and technologies, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Metabolic and endocrine, Good Health and Well Being, Adult, Aged, Aspirin, Calcinosis, Coronary Artery Disease, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveIt is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain.Research design and methodsOf 44,052 asymptomatic individuals referred for CAC testing, we studied 2,384 individuals with diabetes. Subjects were followed for a mean of 5.6 ± 2.6 years for the end point of all-cause mortality.ResultsThere were 162 deaths (6.8%) in the population. CAC was a strong predictor of mortality across age-groups (age

Published
2012

57. Long-term prognostic impact of CT-Leaman score in patients with non-obstructive CAD: Results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) study

Author

Andreini, Daniele, Pontone, Gianluca, Mushtaq, Saima, Gransar, Heidi, Conte, Edoardo, Bartorelli, Antonio L., Pepi, Mauro, Opolski, Maksymilian P., ó Hartaigh, Bríain, Berman, Daniel S., Budoff, Matthew J., Achenbach, Stephan, Al-Mallah, Mouaz, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J.W., Cury, Ricardo, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A., Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Marques, Hugo, Rubinshtein, Ronen, Hindoyan, Niree, Gomez, Millie, and Min, James K

Published
2017
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58. What does my patient's coronary artery calcium score mean? Combining information from the coronary artery calcium score with information from conventional risk factors to estimate coronary heart disease risk.

Author

Pletcher, Mark J, Tice, Jeffrey A, Pignone, Michael, McCulloch, Charles, Callister, Tracy Q, and Browner, Warren S

Subjects
Humans, Coronary Disease, Diabetic Angiopathies, Hypertension, Calcinosis, Hypercholesterolemia, Tomography, X-Ray Computed, Risk Assessment, Risk Factors, Regression Analysis, Age Factors, Sex Factors, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundThe coronary artery calcium (CAC) score is an independent predictor of coronary heart disease. We sought to combine information from the CAC score with information from conventional cardiac risk factors to produce post-test risk estimates, and to determine whether the score may add clinically useful information.MethodsWe measured the independent cross-sectional associations between conventional cardiac risk factors and the CAC score among asymptomatic persons referred for non-contrast electron beam computed tomography. Using the resulting multivariable models and published CAC score-specific relative risk estimates, we estimated post-test coronary heart disease risk in a number of different scenarios.ResultsAmong 9341 asymptomatic study participants (age 35-88 years, 40% female), we found that conventional coronary heart disease risk factors including age, male sex, self-reported hypertension, diabetes and high cholesterol were independent predictors of the CAC score, and we used the resulting multivariable models for predicting post-test risk in a variety of scenarios. Our models predicted, for example, that a 60-year-old non-smoking non-diabetic women with hypertension and high cholesterol would have a 47% chance of having a CAC score of zero, reducing her 10-year risk estimate from 15% (per Framingham) to 6-9%; if her score were over 100, however (a 17% chance), her risk estimate would be markedly higher (25-51% in 10 years). In low risk scenarios, the CAC score is very likely to be zero or low, and unlikely to change management.ConclusionCombining information from the CAC score with information from conventional risk factors can change assessment of coronary heart disease risk to an extent that may be clinically important, especially when the pre-test 10-year risk estimate is intermediate. The attached spreadsheet makes these calculations easy.

Published
2004

60. Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography

Author

van Rosendael, Sophie E; https://orcid.org/0000-0002-1111-7971, Bax, A Maxim, Lin, Fay Y, Achenbach, Stephan; https://orcid.org/0000-0002-7596-095X, Andreini, Daniele, Budoff, Matthew J; https://orcid.org/0000-0002-9616-1946, Cademartiri, Filippo; https://orcid.org/0000-0002-0579-3279, Callister, Tracy Q, Chinnaiyan, Kavitha, Chow, Benjamin J W; https://orcid.org/0000-0001-8631-0234, Cury, Ricardo C; https://orcid.org/0000-0001-6948-2886, DeLago, Augustin J, Feuchtner, Gudrun; https://orcid.org/0000-0001-6755-4399, Hadamitzky, Martin; https://orcid.org/0000-0001-6267-1692, Hausleiter, Joerg, Kaufmann, Philipp A; https://orcid.org/0000-0002-9451-5210, Kim, Yong-Jin; https://orcid.org/0000-0002-1366-432X, Leipsic, Jonathon A, Maffei, Erica; https://orcid.org/0000-0002-0388-4433, Marques, Hugo; https://orcid.org/0000-0001-8210-2075, de Araújo Gonçalves, Pedro; https://orcid.org/0000-0003-4301-3090, Pontone, Gianluca; https://orcid.org/0000-0002-1339-6679, Raff, Gilbert L; https://orcid.org/0000-0002-8363-2024, Rubinshtein, Ronen, Villines, Todd C, Chang, Hyuk-Jae; https://orcid.org/0000-0002-6139-7545, Berman, Daniel S; https://orcid.org/0000-0002-3793-9578, Min, James K, Bax, Jeroen J; https://orcid.org/0000-0001-7368-0500, Shaw, Leslee J, et al, van Rosendael, Sophie E; https://orcid.org/0000-0002-1111-7971, Bax, A Maxim, Lin, Fay Y, Achenbach, Stephan; https://orcid.org/0000-0002-7596-095X, Andreini, Daniele, Budoff, Matthew J; https://orcid.org/0000-0002-9616-1946, Cademartiri, Filippo; https://orcid.org/0000-0002-0579-3279, Callister, Tracy Q, Chinnaiyan, Kavitha, Chow, Benjamin J W; https://orcid.org/0000-0001-8631-0234, Cury, Ricardo C; https://orcid.org/0000-0001-6948-2886, DeLago, Augustin J, Feuchtner, Gudrun; https://orcid.org/0000-0001-6755-4399, Hadamitzky, Martin; https://orcid.org/0000-0001-6267-1692, Hausleiter, Joerg, Kaufmann, Philipp A; https://orcid.org/0000-0002-9451-5210, Kim, Yong-Jin; https://orcid.org/0000-0002-1366-432X, Leipsic, Jonathon A, Maffei, Erica; https://orcid.org/0000-0002-0388-4433, Marques, Hugo; https://orcid.org/0000-0001-8210-2075, de Araújo Gonçalves, Pedro; https://orcid.org/0000-0003-4301-3090, Pontone, Gianluca; https://orcid.org/0000-0002-1339-6679, Raff, Gilbert L; https://orcid.org/0000-0002-8363-2024, Rubinshtein, Ronen, Villines, Todd C, Chang, Hyuk-Jae; https://orcid.org/0000-0002-6139-7545, Berman, Daniel S; https://orcid.org/0000-0002-3793-9578, Min, James K, Bax, Jeroen J; https://orcid.org/0000-0001-7368-0500, Shaw, Leslee J, and et al

Abstract

AIMS The totality of atherosclerotic plaque derived from coronary computed tomography angiography (CCTA) emerges as a comprehensive measure to assess the intensity of medical treatment that patients need. This study examines the differences in age onset and prognostic significance of atherosclerotic plaque burden between sexes. METHODS AND RESULTS From a large multi-center CCTA registry the Leiden CCTA score was calculated in 24 950 individuals. A total of 11 678 women (58.5 ± 12.4 years) and 13 272 men (55.6 ± 12.5 years) were followed for 3.7 years for major adverse cardiovascular events (MACE) (death or myocardial infarction). The age where the median risk score was above zero was 12 years higher in women vs. men (64-68 years vs. 52-56 years, respectively, P < 0.001). The Leiden CCTA risk score was independently associated with MACE: score 6-20: HR 2.29 (1.69-3.10); score > 20: HR 6.71 (4.36-10.32) in women, and score 6-20: HR 1.64 (1.29-2.08); score > 20: HR 2.38 (1.73-3.29) in men. The risk was significantly higher for women within the highest score group (adjusted P-interaction = 0.003). In pre-menopausal women, the risk score was equally predictive and comparable with men. In post-menopausal women, the prognostic value was higher for women [score 6-20: HR 2.21 (1.57-3.11); score > 20: HR 6.11 (3.84-9.70) in women; score 6-20: HR 1.57 (1.19-2.09); score > 20: HR 2.25 (1.58-3.22) in men], with a significant interaction for the highest risk group (adjusted P-interaction = 0.004). CONCLUSION Women developed coronary atherosclerosis approximately 12 years later than men. Post-menopausal women within the highest atherosclerotic burden group were at significantly higher risk for MACE than their male counterparts, which may have implications for the medical treatment intensity.

Published
2023

61. Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography

Author

van Rosendael, Sophie E, primary, Bax, A Maxim, additional, Lin, Fay Y, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz H, additional, Andreini, Daniele, additional, Budoff, Matthew J, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J W, additional, Cury, Ricardo C, additional, DeLago, Augustin J, additional, Feuchtner, Gudrun, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp A, additional, Kim, Yong-Jin, additional, Leipsic, Jonathon A, additional, Maffei, Erica, additional, Marques, Hugo, additional, de Araújo Gonçalves, Pedro, additional, Pontone, Gianluca, additional, Raff, Gilbert L, additional, Rubinshtein, Ronen, additional, Villines, Todd C, additional, Chang, Hyuk-Jae, additional, Berman, Daniel S, additional, Min, James K, additional, Bax, Jeroen J, additional, Shaw, Leslee J, additional, and van Rosendael, Alexander R, additional

Published
2023
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64. When Does a Calcium Score Equates to Secondary Prevention?: Insights From the Multinational CONFIRM Registry

Author

Budoff, Matthew J, Kinninger, April, Gransar, Heidi, Achenbach, Stephan, Al-Mallah, Mouaz H, Bax, Jeroen J, Berman, Daniel S, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chow, Benjamin J W, Cury, Ricardo C, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Leipsic, Jonathon, Lin, Fay Y, Kim, Yong-Jin, Marques, Hugo, Pontone, Gianluca, Rubinshtein, Ronen, Shaw, Leslee J, Villines, Todd C, Min, James K, CONFIRM Investigators, and University of Zurich

Subjects
610 Medicine & health, 10181 Clinic for Nuclear Medicine
Published
2023

66. Calcium score, coronary artery disease extent and severity, and clinical outcomes among low Framingham risk patients with low vs high lifetime risk: Results from the CONFIRM registry

Author

Hulten, Edward, Villines, Todd C., Cheezum, Michael K., Berman, Daniel S., Dunning, Allison, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor Y., Chinnaiyan, Kavitha, Chow, Benjamin J.W., Cury, Ricardo C., Delago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jörg, Kaufmann, Philipp A., Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Plank, Fabian, Raff, Gilbert L., Shaw, Leslee J., and Min, James K.

Published
2014
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68. Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography.

Author

Rosendael, Sophie E van, Bax, A Maxim, Lin, Fay Y, Achenbach, Stephan, Andreini, Daniele, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chinnaiyan, Kavitha, Chow, Benjamin J W, Cury, Ricardo C, DeLago, Augustin J, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Kim, Yong-Jin, Leipsic, Jonathon A, Maffei, Erica, and Marques, Hugo

Subjects
RESEARCH, PERIMENOPAUSE, AGE distribution, PATHOLOGICAL anatomy, MAJOR adverse cardiovascular events, SEX distribution, CORONARY angiography, CORONARY artery disease, POSTMENOPAUSE, COMPUTED tomography
Abstract

Aims The totality of atherosclerotic plaque derived from coronary computed tomography angiography (CCTA) emerges as a comprehensive measure to assess the intensity of medical treatment that patients need. This study examines the differences in age onset and prognostic significance of atherosclerotic plaque burden between sexes. Methods and results From a large multi-center CCTA registry the Leiden CCTA score was calculated in 24 950 individuals. A total of 11 678 women (58.5 ± 12.4 years) and 13 272 men (55.6 ± 12.5 years) were followed for 3.7 years for major adverse cardiovascular events (MACE) (death or myocardial infarction). The age where the median risk score was above zero was 12 years higher in women vs. men (64–68 years vs. 52–56 years, respectively, P < 0.001). The Leiden CCTA risk score was independently associated with MACE: score 6–20: HR 2.29 (1.69–3.10); score > 20: HR 6.71 (4.36–10.32) in women, and score 6–20: HR 1.64 (1.29–2.08); score > 20: HR 2.38 (1.73–3.29) in men. The risk was significantly higher for women within the highest score group (adjusted P -interaction = 0.003). In pre-menopausal women, the risk score was equally predictive and comparable with men. In post-menopausal women, the prognostic value was higher for women [score 6–20: HR 2.21 (1.57–3.11); score > 20: HR 6.11 (3.84–9.70) in women; score 6–20: HR 1.57 (1.19–2.09); score > 20: HR 2.25 (1.58–3.22) in men], with a significant interaction for the highest risk group (adjusted P -interaction = 0.004). Conclusion Women developed coronary atherosclerosis approximately 12 years later than men. Post-menopausal women within the highest atherosclerotic burden group were at significantly higher risk for MACE than their male counterparts, which may have implications for the medical treatment intensity. [ABSTRACT FROM AUTHOR]

Published
2023
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69. Predictive Value of Cardiac Computed Tomography and the Impact of Renal Function on All Cause Mortality (from Coronary Computed Tomography Angiography Evaluation for Clinical Outcomes)

Author

Dwivedi, Girish, Cocker, Myra, Yam, Yeung, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel S., Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha M., Delago, Augustin, Dunning, Allison M., Hadamitzky, Martin, Hausleiter, Jörg, Kaufmann, Philipp A., LaBounty, Troy M., Lin, Fay, Maffei, Erica, Raff, Gilbert L., Shaw, Leslee J., Villines, Todd C., Min, James K., and Chow, Benjamin J.W.

Published
2013
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70. Impact of Family History of Coronary Artery Disease in Young Individuals (from the CONFIRM Registry)

Author

Otaki, Yuka, Gransar, Heidi, Berman, Daniel S., Cheng, Victor Y., Dey, Damini, Lin, Fay Y., Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J.W., Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, and Min, James K.

Published
2013
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71. Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography

Author

Nakazato, Ryo, Gransar, Heidi, Berman, Daniel S., Cheng, Victor Y., Lin, Fay Y., Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J.W., Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Cury, Ricardo C., Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, and Min, James K.

Published
2013
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72. Usefulness of Coronary Computed Tomography Angiography to Predict Mortality and Myocardial Infarction Among Caucasian, African and East Asian Ethnicities (from the CONFIRM [Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter] Registry)

Author

Hulten, Edward, Villines, Todd C., Cheezum, Michael K., Berman, Daniel S., Dunning, Allison, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor Y., Chinnaiyan, Kavitha, Chow, Benjamin J.W., Cury, Ricardo C., Delago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jörg, Kaufmann, Philipp A., Karlsberg, Ronald P., Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Plank, Fabian, Raff, Gilbert L., Labounty, Troy M., Shaw, Leslee J., and Min, James K.

Published
2013
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73. Abstract 18737: Effect of Non-Statin Lipid-Lowering Drug Therapy on Coronary Plaque Composition as Assessed by Coronary Computed Tomography Angiography

Author

Su, Amanda, van den Hoogen, Inge, Lu, Yao, Rizvi, Asim, Berman, Daniel, Callister, Tracy, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Al-Mallah, Mouaz, Budoff, Matthew, Kaufmann, Philipp, Raff, Gilbert, Chinnaiyan, Kavitha, Cademartiri, Filippo, Maffei, Erica, Villines, Todd, Kim, Yong-Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Achenbach, Stephan, Shaw, Leslee, Dunning, Allison, Chang, Hyuk-Jae, Chow, Benjamin, Cury, Ricardo, Gomez, Millie, Hindoyan, Niree, Jones, Erica C, Peña, Jessica M, Lin, Fay Y, Min, James K, and AlʼAref, Subhi J

Published
2017

75. Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry

Author

Nakazato, Ryo, Gransar, Heidi, Berman, Daniel S., Cheng, Victor Y., Lin, Fay Y., Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cury, Ricardo C., Chinnaiyan, Kavitha, Chow, Benjamin J.W., Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, and Min, James K.

Published
2012
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77. Coronary CT angiography versus myocardial perfusion imaging for near-term quality of life, cost and radiation exposure: A prospective multicenter randomized pilot trial

Author

Min, James K., Koduru, Sunaina, Dunning, Allison M., Cole, Jason H., Hines, Jerome L., Greenwell, Dawn, Biga, Cathie, Fanning, Gayle, LaBounty, Troy M., Gomez, Millie, Horowitz, James M., Hadimitzsky, Martin, Hausleiter, Jorg, Callister, Tracy Q., Rosanski, Alan R., Shaw, Leslee J., Berman, Daniel S., and Lin, Fay Y.

Published
2012
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79. Rationale and design of the CONFIRM ( COronary CT Angiography Evaluatio N For Clinical Outcomes: An Inte Rnational Multicenter) Registry

Author

Min, James K., Dunning, Allison, Lin, Fay Y., Achenbach, Stephan, Al-Mallah, Mouaz H., Berman, Daniel S., Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha M., Chow, Benjamin, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Jorg, Karlsberg, Ronald P., Kaufmann, Philipp, Maffei, Erica, Nasir, Khurram, Pencina, Michael J., Raff, Gilbert L., Shaw, Leslee J., and Villines, Todd C.

Published
2011
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80. Current trends in patients with chronic total occlusions undergoing coronary CT angiography

Author

Opolski, Maksymilian P, ó Hartaigh, Bríain, Berman, Daniel S, Budoff, Matthew J, Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J W, Hadamitzky, Martin, Hausleiter, Joerg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A, Leipsic, Jonathon, Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J, Villines, Todd C, Min, James K, Gransar, Heidi, Schulman-Marcus, Joshua, Truong, Quynh A, Callister, Tracy Q, Cury, Ricardo, DeLago, Augustin, Gomez, Millie, Hindoyan, Niree, Lin, Fay Y, and Dunning, Allison

Published
2015
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84. Prognostic significance of plaque location in non-obstructive coronary artery disease: from the CONFIRM registry

Author

Han, Donghee, primary, Chen, Billy, additional, Gransar, Heidi, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz H, additional, Budoff, Matthew J, additional, Cademartiri, Filippo, additional, Maffei, Erica, additional, Callister, Tracy Q, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J W, additional, DeLago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp A, additional, Villines, Todd C, additional, Kim, Yong Jin, additional, Leipsic, Jonathon, additional, Feuchtner, Gudrun, additional, Cury, Ricardo C, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Marques, Hugo, additional, Rubinshtein, Ronen, additional, Chang, Hyuk Jae, additional, Lin, Fay Y, additional, Shaw, Leslee J, additional, Min, James K, additional, and Berman, Daniel S, additional

Published
2021
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85. What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography

Author

Otaki, Yuka, Arsanjani, Reza, Gransar, Heidi, Cheng, Victor Y., Dey, Damini, Labounty, Troy, Lin, Fay Y., Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J. W., Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Cury, Ricardo C., Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Berman, Daniel S., and Min, James K.

Published
2012
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90. Does coronary CT angiography improve risk stratification over coronary calcium scoring in symptomatic patients with suspected coronary artery disease? Results from the prospective multicenter international CONFIRM registry

Author

Al-Mallah, Mouaz H., Qureshi, Waqas, Lin, Fay Y., Achenbach, Stephan, Berman, Daniel S., Budoff, Matthew J., Callister, Tracy Q., Chang, Hyuk-Jae, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin J. W., Cheng, Victor Y., DeLago, Augustin, Gomez, Millie, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A., Leipsic, Jonathon, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Cury, Ricardo C., Feuchtner, Gudrun, Plank, Fabian, Kim, Yong-Jin, Dunning, Allison M., and Min, James K.

Published
2014
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92. Prognostic significance of plaque location in non-obstructive coronary artery disease: from the CONFIRM registry.

Author

Han, Donghee, Han, Donghee, Chen, Billy, Gransar, Heidi, Achenbach, Stephan, Al-Mallah, Mouaz H, Budoff, Matthew J, Cademartiri, Filippo, Maffei, Erica, Callister, Tracy Q, Chinnaiyan, Kavitha, Chow, Benjamin JW, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Villines, Todd C, Kim, Yong-Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Cury, Ricardo C, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Chang, Hyuk-Jae, Lin, Fay Y, Shaw, Leslee J, Min, James K, Berman, Daniel S, Han, Donghee, Han, Donghee, Chen, Billy, Gransar, Heidi, Achenbach, Stephan, Al-Mallah, Mouaz H, Budoff, Matthew J, Cademartiri, Filippo, Maffei, Erica, Callister, Tracy Q, Chinnaiyan, Kavitha, Chow, Benjamin JW, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Villines, Todd C, Kim, Yong-Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Cury, Ricardo C, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Chang, Hyuk-Jae, Lin, Fay Y, Shaw, Leslee J, Min, James K, and Berman, Daniel S

Abstract

AimObstructive coronary artery disease (CAD) in proximal coronary segments is associated with a poor prognosis. However, the relative importance of plaque location regarding the risk for major adverse cardiovascular events (MACE) in patients with non-obstructive CAD has not been well defined.Methods and resultsFrom the Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter (CONFIRM) registry, 4644 patients without obstructive CAD were included in this study. The degree of stenosis was classified as 0 (no) and 1-49% (non-obstructive). Proximal involvement was defined as any plaque present in the left main or the proximal segment of the left anterior descending artery, left circumflex artery, and right coronary artery. Extensive CAD was defined as segment involvement score of >4. During a median follow-up of 5.2 years (interquartile range 4.1-6.0), 340 (7.3%) MACE occurred. Within the non-obstructive CAD group (n = 2065), proximal involvement was observed in 1767 (85.6%) cases. When compared to non-obstructive CAD patients without proximal involvement, those with proximal involvement had an increased MACE risk (log-rank P = 0.033). Multivariate Cox analysis showed when compared to patients with no CAD, proximal non-obstructive CAD was associated with increased MACE risk [hazard ratio (HR) 1.90, 95% confidence interval (CI) 1.47-2.45, P < 0.001] after adjusting for extensive CAD and conventional cardiovascular risk factors; however, non-proximal non-obstructive CAD did not increase MACE risk (HR 1.26, 95% CI 0.79-2.01, P = 0.339).ConclusionsIndependent of plaque extent, proximal coronary involvement was associated with increased MACE risk in patients with non-obstructive CAD. The plaque location information by coronary computed tomography angiography may provide additional risk prediction over CAD extent in patients with non-obstructive CAD.

Published
2021

93. Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial

Author

Maggioni, Aldo P., Greene, Stephen J., Fonarow, Gregg C., Böhm, Michael, Zannad, Faiez, Solomon, Scott D., Lewis, Eldrin F., Baschiera, Fabio, Hua, Tsushung A., Gimpelewicz, Claudio R., Lesogor, Anastasia, Gheorghiade, Mihai, Ramos, Silvina, Luna, Alejandra, Miriuka, Santiago, Diez, Mirta, Perna, Eduardo, Luquez, Hugo, Pinna, Jorge Garcia, Castagnino, Jorge, Alvarenga, Pablo, Ibañez, Julio, Blumberg, Eduardo Salmon, Dizeo, Claudio, Guerrero, Rodolfo Ahuad, Schygiel, Pablo, Milesi, Rodolfo, Sosa, Carlos, Hominal, Miguel, Marquez, Lilia Lobo, Poy, Carlos, Hasbani, Eduardo, Vico, Marisa, Fernandez, Alberto, Vita, Nestor, Vanhaecke, Johan, De Keulenaer, Gilles, Striekwold, Harry, Vervoort, Geert, Vrolix, Mathias, Henry, Philippe, Dendale, Paul, Smolders, Walter, Marechal, Patrick, Vandekerckhove, Hans, Oliveira, Mucio, Jr., Neuenschwande, Fernando, Reis, Gilmar, Saraiva, Jose, Bodanese, Luiz, Canesin, Manoel, Greco, Oswaldo, Bassan, Roberto, Marino, Roberto Luis, Giannetti, Nadia, Moe, Gordon, Sussex, Bruce, Sheppard, Richard, Huynh, Thao, Stewart, Robert, Haddad, Haissam, Echeverria, Luis, Quintero, Adalberto, Torres, Adriana, Jaramillo, Mónica, Lopez, Mónica, Mendoza, Fernan, Florez, Noel, Cotes, Carlos, Garcia, Magali, Belohlavek, Jan, Hradec, Jaromir, Peterka, Martin, Gregor, Pavel, Monhart, Zdenek, Jansky, Petr, Kettner, Jiri, Reichert, Petr, Spinar, Jindrich, Brabec, Tomas, Hutyra, Martin, Solar, Miroslav, Pietilä, Mikko, Nyman, Kai, Pajari, Risto, Cohen, Ariel, Galinier, Michel, Gosse, Philippe, Livarek, Bernard, Neuder, Yannick, Jourdain, Patrick, Picard, François, Isnard, Richard, Hoppe, Uta, Kaeaeb, Stefan, Rosocha, Stefan, Prondzinsky, Roland, Felix, Stephan, Duengen, Hans-Dirk, Figulla, Hans-Reiner, Fischer, Sven, Behrens, Steffen, Stawowy, Philipp, Kruells-Muench, Juergen, Knebel, Fabian, Nienaber, Christoph, Werner, Dierk, Aron, Wilma, Remppis, Bjoern, Hambrecht, Rainer, Kisters, Klaus, Werner, Nikos, Hoffmann, Stefan, Rossol, Siegbert, Geiss, Ernst, Graf, Kristof, Hamann, Frank, von Scheidt, Wolfgang, Schwinger, Robert, Tebbe, Ulrich, Costard-Jaeckle, Angelika, Lueders, Stephan, Heitzer, Thomas, Leutermann-Oei, Marie-Louise, Braun-Dullaeus, Ruediger, Roehnisch, Jens-Uwe, Muth, Gerhard, Goette, Andreas, Rotter, Achim, Ebelt, Henning, Olbrich, Hans-Georg, Mitrovic, Veselin, Hengstenberg, Christian, Schellong, Sebastian, Zamolyi, Karoly, Vertes, Andras, Matoltsy, Andras, Palinkas, Attila, Herczeg, Bela, Apro, Dezso, Lupkovics, Geza, Tomcsanyi, Janos, Toth, Kalman, Mathur, Atul, Banker, Darshan, Bharani, Anil, Arneja, Jaspal, Khan, Aziz, Gadkari, Milind, Hiremath, Jagdish, Patki, Nitin, Kumbla, Makund, Santosh, M.J., Ravikishore, A.G., Abhaichand, Rajpal, Maniyal, Vijayakukmar, Nanjappa, Manjunath, Reddy, P. Naveen, Chockalingam, Kulasekaran, Premchand, Rajendra, Mahajan, Vijay, Lewis, Basil, Wexler, Dov, Shochat, Michael, Keren, Andre, Omary, Muhamad, Katz, Amos, Marmor, Alon, Lembo, Giuseppe, Di Somma, Salvatore, Boccanelli, Alessandro, Barbiero, Mario, Pajes, Giuseppe, De Servi, Stefano, Greco, Dott Cosimo, De Santis, Fernando, Floresta, Agata, Visconti, Luigi Oltrona, Piovaccari, Giancarlo, Cavallini, Claudio, Di Biase, Matteo, Masini, Dott Franco, Vassanelli, Corrado, Viecca, Maurizio, Cangemi, Dott Francesco, Pirelli, Salvatore, Borghi, Claudio, Volpe, Massimo, Branzi, Angelo, Percoco, Dott Giovanni, Severi, Silvia, Santini, Alberto, De Lorenzi, Ettore, Metra, Marco, Zacà, Valerio, Mortara, Andrea, Tranquilino, Francisco P., Babilonia, Noe A., Ferrolino, Arthur M., Manlutac, Benjamin, Jr, Dluzniewski, Miroslaw, Dzielinska, Zofia, Nowalany-Kozie, Ewa, Mazurek, Walentyna, Wierzchowiecki, Jerzy, Wysokinski, Andrzej, Szachniewicz, Joanna, Romanowski, Witold, Krauze-Wielicka, Magdalena, Jankowski, Piotr, Berkowski, Piotr, Szelemej, Roman, Kleinrok, Andrzej, Kornacewicz-Jac, Zdzislawa, Vintila, Marius, Vladoianu, Mircea, Militaru, Constantin, Dan, Gheorghe, Dorobantu, Maria, Dragulescu, Stefan, Kostenko, Victor, Vishnevsky, Alexandr, Goloschekin, Boris, Tyrenko, Vadim, Gordienko, Alexander, Kislyak, Oxana, Martsevich, Sergey, Kuchmin, Alexey, Karpov, Yurii, Fomin, Igor, Shvarts, Yury, Orlikova, Olga, Ershova, Olga, Berkovich, Olga, Sitnikova, Maria, Pakhomova, Inna, Boldueva, Svetlana, Tyurina, Tatiana, Simanenkov, Vladimir, Boyarkin, Mikhail, Novikova, Nina, Tereschenko, Sergey, Zadionchenko, Vladimir, Shogenov, Zaur, Gordeev, Ivan, Moiseev, Valentin, Wong, Raymond, Ong, Hean Yee, Le Tan, Ju, Goncalvesova, Eva, Kovar, Frantisek, Skalina, Ivan, Kasperova, Viera, Hojerova, Silvia, Szentivanyi, Miroslav, Stancak, Branislav, Babcak, Marian, Kycina, Peter, Poliacik, Pavol, Toth, Peter, Sirotiakova, Jana, de Sa, Esteban Lopez, Bueno, Manuel Gomez, Selles, Manuel Martinez, Cabrera, Jose Angel, Freire, Ramon Bover, Gonzalez Juanatey, Jose Ramon, Comin, Josep, Soriano, FranciscoRidocci, Lopez, Alejandro, Vicho, Raul, Lama, Manuel Geraldia, Schaufelberger, Maria, Brunotte, Richard, Ullman, Bengt, Hagerman, Inger, Cizinsky, Stella, Cherng, Wen-Jin, Yu, Wen-Chung, Kuo, Chi-Tai, Chang, Kuan-Cheng, Lai, Wen-Ter, Kuo, Jen-Yuan, Ural, Dilek, Badak, Ozer, Akin, Mustafa, Yigit, Zerrin, Yokusoglu, Mehmet, Yilmaz, Mehmet, Abaci, Adnan, Ebinc, Haksun, Perlman, Richard, Parish, David, Bergin, James, Burnham, Kenneth, Brown, Christopher, Lundbye, Justin, Williams, Celeste, Eisen, Howard, Juneman, Elizabeth, Joseph, Susan, Peberdy, Mary Ann, Peura, Jennifer, Gupta, Vishal, Habet, Kalim, French, William, Mody, Freny, Graham, Susan, Hazelrigg, Monica, Chung, Eugene, Dunlap, Stephanie, Nikolaidis, Lazaros, Najjar, Samer, Katz, Richard, Murali, Srinivas, Izzo, Joseph L., Callister, Tracy, Phillips, Roland, Lippolis, Nicholas, Winterton, John, Meymandi, Sheba, Heilman, Karl, III, Oren, Ron, Zolty, Ronald, Brottman, Michael, Gunawardena, D.R., Adams, Kirkwood, Barnard, Denise, Klapholz, Marc, and Fulmer, James

Published
2013
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94. Body mass index and the prevalence, severity, and risk of coronary artery disease: an international multicentre study of 13 874 patients

Author

Labounty, Troy M., Gomez, Millie J., Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel S., Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha M., Chow, Benjamin, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jorg, Kaufmann, Philipp, Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., and Min, James K.

Published
2013
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96. Contributors

Author

Abbara, Suhny, primary, Achenbach, Stephan, additional, Ahmadi, Naser, additional, Alkadhi, Hatem, additional, Bax, Jeroen J., additional, Bolen, Michael A., additional, Boxt, Lawrence M., additional, Budoff, Matthew J., additional, Bush, David, additional, Callister, Tracy Q., additional, Carr, J. Jeffrey, additional, Cook, Stephen C., additional, Cury, Ricardo C., additional, Cury, Roberto C., additional, Di Carli, Marcelo F., additional, Dodd, Jonathan D., additional, Fleischmann, Dominik, additional, George, Richard T., additional, Gerber, Thomas C., additional, Hecht, Harvey S., additional, Kantor, Birgit, additional, Lardo, Albert C., additional, Lima, Joao A.C., additional, Mahnken, Andreas H., additional, Makaryus, Amgad N., additional, Rumberger, John A., additional, Schuijf, Joanne D., additional, Shinbane, Jerold S., additional, Shriki, Jabi, additional, Taylor, Allen J., additional, Guy Weigold, Wm., additional, and Williamson, Eric E., additional

Published
2010
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98. All-cause mortality benefit of coronary revascularization vs. medical therapy in patients without known coronary artery disease undergoing coronary computed tomographic angiography: results from CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry)

Author

Min, James K., Berman, Daniel S., Dunning, Allison, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor, Chinnaiyan, Kavitha, Chow, Benjamin J.W., Cury, Ricardo, Delago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Karlsberg, Ronald P., Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Plank, Fabian, Raff, Gilbert, Villines, Todd, Labounty, Troy M., and Shaw, Leslee J.

Published
2012
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