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52. Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research.

Author

Hajat, Cother, Stein, Emma, Selya, Arielle, Polosa, Riccardo, The CoEHAR study group, Alaimo, Salvatore, Anfuso, Carmelina Daniela, Barbagallo, Ignazio, Basile, Francesco, Battiato, Sebastiano, Benhamou, Brahim, Bertino, Gaetano, Bianchi, Alberto, Biondi, Antonio G, Brandi, Maria Luisa, Cacciola, Emma, Cacciola, Rossella R, Cacopardo, Bruno Santi, Calogero, Aldo E, and Cambria, Maria Teresa

Subjects
SMOKING cessation, RESEARCH funding, SMOKING, EPIDEMIOLOGICAL research
Abstract

The prevalence of vaping, also known as using e-cigarettes, vapes and vape pens, has prompted a demand for reliable, evidence-based research. However, published literature on the topic of vaping often raises concerns, characterized by serious flaws and a failure to adhere to accepted scientific methodologies. In this narrative review, we analyze popular vaping studies published in medical journals that purport to evaluate the association of vaping and smoking cessation, smoking initiation or health outcomes. We analyzed 24 included studies to identify the questions they claimed to address, stated methods, manner of implementation, discussions, and stated conclusions. After critical appraisal, we noted a multiplicity of flaws in these studies, and identified patterns as to the nature of such flaws. Many studies lacked a clear hypothesis statement: to the extent that a hypothesis could be inferred, the methods were not tailored to address the question of interest. Moreover, main outcome measures were poorly identified, and data analysis was further complicated by failure to control for confounding factors. The body of literature on "gateway" theory for the initiation of smoking was particularly unreliable. Overall, the results and discussion contained numerous unreliable assertions due to poor methods, including data collection that lacked relevance, and assertions that were unfounded. Many researchers claimed to find a causal association while not supporting such findings with meaningful data: the discussions and conclusions of such studies were, therefore, misleading. Herein, we identify the common flaws in the study design, methodology, and implementation found in published vaping studies. We present our summary recommendations for future vaping research. Our aim is to prompt future researchers to adhere to scientific methods to produce more reliable findings and conclusions in the field of vaping research. [ABSTRACT FROM AUTHOR]

Published
2022
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55. Randomized trial of two schedules of low-dose gemtuzumab ozogamicin as induction monotherapy for newly diagnosed acute myeloid leukaemia in older patients not considered candidates for intensive chemotherapy. A phase II study of the EORTC and GIMEMA leukaemia groups (AML-19)

Author

Amadori, Sergio, Suciu, Stefan, Selleslag, Dominik, Stasi, Roberto, Alimena, Giuliana, Baila, Liliana, Rizzoli, Vittorio, Borlenghi, Erika, Gaidano, Gianluca, Magro, Domenico, Torelli, Giuseppe, Muus, Petra, Venditti, Adriano, Cacciola, Emma, Lauria, Francesco, Vignetti, Marco, and de Witte, Theo

Published
2010
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67. Sopravvivenza libera da trombosi in 734 pazienti con trombocitemia essenziale (WHO 2016) stratificati secondo lo score 'Revised International Prognostic Score for Thrombosis in Essential Thrombocythemia (R-IPSET-Th)'. Studio del Regostro ItalianoTrombocitemie (RIT)

Author

Gugliotta, L, Iurlo, A, Gugliotta, G, Tieghi, A, Gaidano, G, Dragani, A, Scalzulli, P, Martinelli, V, Martino, B, Randi, Ml, Cattaneo, D, Appolloni, V, Maschio, N, Langella, M, Santoro, C, Rago, A, Cacciola, Emma, Cacciola, Rossella Rosaria, Caocci, G, Plebani, S, Santoro, U, Vianelli, N, Mazzucconi, Mg, Specchia, G, Passamonti, F, and Vannucchi, Am

Published
2017

68. Benefit-risk profile of hydroxyurea and antithrombotic treatment after transient ischemic attack or ischemic stroke in myeloprolifertive neoplasms

Author

Valerio De Stefano, Alessandra, Carobbio, Vincenzo Di Lazzaro, Paola, Giglielmelli, Alessandrte, Iurlo, Maria Chiara Finazzi, Elisa, Rumi, Francosco, Cervantes, Elena Maria Elli, Maria Luigia Randi, Martin, Griesshammer, Francesca, Palandri, Massimiliano, Bonifacio, Juan-Carlos, Hernandez-Boluda, Cacciola, Rossella Rosaria, Palova, Miroslava, Giuseppe, Carli, Eloise, Beggiato, Ellis, Martin H., Caterina, Musolino, Gianluca, Gaidano, Davide, Rapezzi, Alessia, Tieghi, Francesca, Lunghi, Giuseppe, Loscocco, Daniele, Cattaneo, Agostino, Cortelezzi, Silvia, Betti, Elena, Rossi, Giudo, Finazzi, Bruno, Censori, Mario, Cazzola, Marta, Bellini, Eduardo, Arellano-Rodrigo, Irene, Bertozzi, Parvis, Sadjadian, Nicola, Vianelli, Luigi, Scaffidi, Montse, Gomez, Cacciola, Emma, Vannucchi, Alessandro M., and Tiziano, Barbui

Published
2017

74. Unbiased pro-thrombotic features at diagnosis in 977 thrombocythemic patients with Philadelphia-negative chronic myeloproliferative neolpasms

Author

Luigi, Gugliotta, Alessandra, Iurlo, Gabriele, Gugliotta, Alessia, Tieghi, Giogina, Specchia, Gianluca, Gaidano, Potito, R Scalzulli, Elisa, Rumi, Alfredo, Dragani, Vincenzo, Martinelli, Cristina, Santoro, Maria Luigia Randi, Giuseppe, Tagariello, Anna, Candoni, Daniele, Cattaneo, Alessandra, Ricco, Raffaele, Palmieri, Liberati, Marina A., Maria, Langella, Angela, Rago, Micaela, Bergamaschi, Paola, Monari, Rossella, Miglio, Umberto, Santoro, Cacciola, Rossella Rosaria, Cacciola, Emma, Serena, Rupoli, Lucia, Mastrullo, Pellegrino, Musto, Maria Gabriella Mazzucconi, Marco, Vignetti, Agostino, Corelezzi, Nicola, Vianelli, Bruno, Martino, Valerio De STefano, Francesco, Passamonti, Alessandro, M Vannucchi, for the Registro Italiano Trombocitemia RIT, Gugliotta, Luigi, Iurlo, Alessandra, Gugliotta, Gabriele, Tieghi, Alessia, Specchia, Giorgina, Gaidano, Gianluca, Scalzulli, Potito R., Rumi, Elisa, Dragani, Alfredo, Martinelli, Vincenzo, Santoro, Cristina, Randi, Maria Luigia, Tagariello, Giuseppe, Candoni, Anna, Cattaneo, Daniele, Ricco, Alessandra, Palmieri, Raffaele, Liberati, Marina A., Langella, Maria, Rago, Angela, Bergamaschi, Micaela, Monari, Paola, Miglio, Rossella, Santoro, Umberto, Cacciola, Rossella, Rupoli, Serena, Mastrullo, Lucia, Musto, Pellegrino, Mazzucconi, Maria Gabriella, Vignetti, Marco, Cortelezzi, Agostino, Vianelli, Nicola, Martino, Bruno, De Stefano, Valerio, Passamonti, Francesco, and Vannucchi, Alessandro M.

Subjects
Male, Cancer Research, Pathology, Multivariate analysis, Leukocytosis, Hematocrit, Gastroenterology, JAK2, Leukocytes, Platelets, Thrombocythemia, Thrombosis, Hematology, Oncology, 0302 clinical medicine, Risk Factors, Medicine, Thrombophilia, Platelet, Child, Aged, 80 and over, Thrombocytosis, medicine.diagnostic_test, Middle Aged, 030220 oncology & carcinogenesis, Thrombosi, Female, medicine.symptom, Adult, medicine.medical_specialty, Adolescent, 03 medical and health sciences, Young Adult, Internal medicine, Humans, Aged, Philadelphia negative, Myeloproliferative Disorders, business.industry, Platelet Count, Leukocyte, medicine.disease, Settore MED/15 - MALATTIE DEL SANGUE, business, 030215 immunology
Abstract

In patients with Philadelphia-negative chronic myeloproliferative neoplasms (MPNs), the anti-thrombotic and/or cytoreductive treatment in the follow-up may affect the evaluation of the pro-thrombotic weight of the clinical and biological characteristics at diagnosis. In order to avoid this potential confounding effect, we investigated the relationship between prior thrombosis (PrTh: thrombosis occurred before diagnosis and before treatment) and the characteristics at diagnosis in 977 thrombocythemic patients with MPN, reclassified according to the WHO 2008 criteria. PrTh occurred in 194 (19.9%) patients, with similar rates in the different MPNs. In multivariate analysis, PrTh rate was significantly related to minor thrombocytosis (platelets ≤700 × 109/L), leukocytosis (leukocytes >10 × 109/L), higher hematocrit (HCT >45%), JAK2 V617F mutation, older age, and cardiovascular risk factors (CVRFs). The highest PrTh rate (33.9%) was associated with the coexistence of minor thrombocytosis and leukocytosis. Of note, the inverse relationship between PrTh rate and platelet count is consistent with the hemostatic paradox of thrombocytosis. In conclusion, this analysis in MPN patients disclosed the unbiased characteristics at diagnosis with a pro-thrombotic effect. Moreover, it suggests that the optimal control of blood cells counts, and CVRFs might be of utmost importance in the prevention of thrombosis during the follow-up.

Published
2016

78. How the Real-Life Diagnostic and Therapeutic Approach Changed in the Last Two Decades in the Thrombocythemic Patients with Ph- Negative Myeloproliferative Neoplasm. Report on 2388 Subjects of the Registro Italiano Trombocitemie (RIT)

Author

Gugliotta, Luigi, primary, Iurlo, Alessandra, additional, Gugliotta, Gabriele, additional, Tieghi, Alessia, additional, Canafoglia, Lucia, additional, Palmieri, Raffaele, additional, Pasciolla, Crescenza, additional, Vianelli, Nicola, additional, Ragionieri, Riccardo, additional, Rinaldi, Erminia, additional, Usala, Emilio, additional, La Nasa, Giorgio, additional, Perra, Alessandra, additional, Tagariello, Giuseppe, additional, Maschio, Nilla, additional, Cacciola, Emma, additional, Cacciola, Rossella Rosaria, additional, Bergamaschi, Micaela, additional, Da Col, Anna, additional, Rago, Angela, additional, Rizzo, Lorenzo, additional, Spina, Francesco, additional, Cattaneo, Daniele, additional, Lambertenghi, Daniela, additional, Casoria, Aniello, additional, Langella, Maria, additional, Randi, Maria Luigia, additional, Cosi, Elisabetta, additional, Crugnola, Monica, additional, Masselli, Elena, additional, Ranalli, Paola, additional, Garozzo, Giovanni, additional, Codeluppi, Katia, additional, Villani, Oreste, additional, Ferrara, Grazia, additional, Santoro, Cristina, additional, Scalzulli, Potito Rosario, additional, Ricciotti, Manlio, additional, Appolloni, Viviana, additional, Candoni, Anna, additional, Luraschi, Annalisa, additional, Serena, Rupoli, additional, DI Ianni, Mauro, additional, Caocci, Giovanni, additional, Lanza, Francesco, additional, Orofino, Nicola, additional, Rumi, Elisa, additional, Dragani, Alfredo, additional, Martino, Bruno, additional, Liberati, Anna Marina, additional, Santoro, Umberto, additional, and Vannucchi, Alessandro M., additional

Published
2016
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82. The Antiphospholipid Syndrome

Author

Cacciola, Rossella Rosaria, Gentilini Cacciola, E, and Cacciola, Emma

Subjects
Treatment, Coagulation, Pregnancy, Antiphospholipid Antibodies, aPTT, dRVVT, Thrombosis
Published
2015

83. Milza

Author

Vecchio, Rosario, Intagliata, E, Marchese, S, Spataro, L, and Cacciola, Emma

Subjects
splenimegaly, laparoscopic splenectomy, spleen
Published
2014

87. Elective laparoscopic cholecystectomy

Author

Rosario, Vecchio, Cacciola, Emma, MARCELLO DI MARTINO, Antonio, V, Gambelunghe, Murabito, Paolo, and Cacciola, Rossella Rosaria

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Gallbladder, General surgery, medicine.medical_treatment, Gallbladder Stone, Hepatology, medicine.disease, Sickle cell anemia, Surgery, medicine.anatomical_structure, Internal medicine, Medicine, Cholecystectomy, business, Complication, Laparoscopy, Abdominal surgery
Abstract

Background Gallbladder stones are very common in patients with sickle cell disease and are the cause of recurrent abdominal pain. Their management has been highly controversial, especially for children. Nonoperated patients and those treated on an emergency basis have a very high rate of morbidity (>50%).

Published
2001

95. Cytoreductive combination therapy in essential trhombocythemia: preliminary report of the Registro Italiano trombocitemia (RIT)

Author

Gugliotta, L, Scalzulli, P, Tighi, A, Codeluppi, K, Valvano, R, Candoni, A, Chiozzotto, E, Liberati, M, Apolloni, V, Specchia, G, Cacciola, Emma, Cacciola, Rossella Rosaria, Mastrullo, R, Villa, M, Prugnola, M, Martinelli, V, Ciancia, R, Mazzucconi, Mg, Santoro, C, Campana, P, Randi, Ml, De Biasi, E, Maschio, N, Lanza, F, Antonioli, E, Pierri, I, Di Ianni, M, Iurlo, A, Piccin, A, and Cascavilla, N.

Published
2012

97. Low impact of cardiovascular adverse events on anagrelide treatment discontinuation in a cohort of 232 patients with essential thrombocythemia

Author

Gugliotta, L, Tieghi, A, Tortorella, G, Scalzulli, Pr, Ciancia, R, Lunghi, M, Cacciola, Emma, Cacciola, Rossella Rosaria, Candoni, A, Crugnola, M, Codeluppi, K, Usala, E, Specchia, G, Martinelli, V, Palmieri, F, Pierri, I, Liberati, M, Iurlo, A, Grossi, A, Vannucchi, Am, Vianelli, N, Mazzucconi, Mg, on behalf of the Registro Italiano Trombocitemai, Gugliotta, L, Tieghi, A, Tortorella, G, Scalzulli, Pr, Ciancia, R, Lunghi, M, Cacciola, E, Cacciola, R, Candoni, A, Crugnola, M, Codeluppi, K, Usala, E, Specchia, G, Martinelli, Vincenzo, Palmieri, F, Pierri, I, Liberati, Am, Iurlo, A, Grossi, A, Vannucchi, Am, Vianelli, N, and Mazzucconi, M. G.

Subjects
Male, Cancer Research, Adolescent, Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Child, Cohort Studies, Drug-Related Side Effects and Adverse Reactions, Female, Follow-Up Studies, Humans, Middle Aged, Platelet Aggregation Inhibitors, Quinazolines, Retrospective Studies, Thrombocythemia, Essential, Withholding Treatment, Young Adult, Echocardiogram, Essential thrombocythemia, Essential, 80 and over, Palpitations, Medicine, Thrombocythemia, Hematology, Oncology, Anagrelide, Safety, Toxicity, Cardiovascular adverse events, Palpitation, Cohort, Cardiology, medicine.symptom, Cohort study, medicine.drug, medicine.medical_specialty, Internal medicine, Adverse effect, business.industry, Retrospective cohort study, medicine.disease, Discontinuation, business
Abstract

This retrospective study of the thrombocythemia Italian registry (RIT) documented that 71 (30.6%) out of 232 ET patients experienced 88 cardiovascular adverse events (CV-AEs) during anagrelide treatment (522 pt-y). The rate of CV-AEs was: 24.1% for palpitations, 4.3% for angina, 3.5% for arterial hypertension, 3.0% for congestive heart failure, 1.8% for arrhythmia, 0.9% for AMI, 0.4% for pericardial effusion. CV-AEs led to treatment discontinuation in nine (3.9%) patients, while in the remaining cases they were managed by pharmacological intervention and/or patient life style improvement. CV-AEs had no relationship with patient characteristics (including older age). A significant relationship was found only with a higher anagrelide induction dose. In the absence of any agreed protocol, a cardiovascular instrumental evaluation (CV-IE) was performed in 102 (44%) patients before commencement of anagrelide (with higher rate after the anagrelide/Xagrid EMA approval of 2004), and in 84 (36%) patients during treatment. Patients with and without CV-IEs, who resulted completely balanced for all their characteristics, did not significantly differ in the occurrence of CV-AEs. In conclusion, this study on ET patients treated with anagrelide shows that CV-AEs, equally distributed in younger and older subjects, were mostly mild and easily manageable, allowing safe treatment continuation in the majority of cases. Moreover, routinely performing a CV-IE did not appear to anticipate the occurrence of CV-AEs.

Published
2011

98. Short and Long-Term Risk of Major Cardiovascular Events after Ischemic Stroke or Transient Ischemic Attack in Myeloproliferative Neoplasms

Author

Barbui, Tiziano, De Stefano, Valerio, Carobbio, Alessandra, Di Lazzaro, Vincenzo, Guglielmelli, Paola, Loscocco, Giuseppe Gaetano, Iurlo, Alessandra, Cattaneo, Daniele, Cortelezzi, Agostino, Betti, Silvia, Rossi, Elena, Finazzi, Maria Chiara, Finazzi, Guido, Censori, Bruno, Cazzola, Mario, Rumi, Elisa, Bellini, Marta, Cervantes, Francisco, Arellano-Rodrigo, Eduardo, Elli, Elena, Randi, Maria Luigia, Bertozzi, Irene, Griesshammer, Martin, Sadjadian, Parvis, Palandri, Francesca, Vianelli, Nicola, Bonifacio, Massimiliano, Scaffidi, Luigi, Hernandez-Boluda, Juan Carlos, Gomez, Montse, Cacciola, Emma, Cacciola, Rossella Rosari, Miroslava, Palova, Carli, Giuseppe, Beggiato, Eloise, Ellis, Martin H, Musolino, Caterina, Gaidano, Gianluca, Rapezzi, Davide, Tieghi, Alessia, Lunghi, Francesca, and Vannucchi, Alessandro M.

Published
2017
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