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Una raccolta completa degli scritti di Alain Badiou sul teatro, dal 1990 ad oggi, che comprende la famosa Rapsodia per il teatro ed altri ulteriori interventi sui rapporti tra teatro e filosofia, teatro e politica e sulla commedia. Pubblicati per la prima volta in Italia, questi testi riconsegnano al lettore l'interezza dell'ultima grande teoria del teatro contemporaneo, il lungo e intenso lavoro di uno dei più importanti intellettuali e filosofi del nostro tempo. "Al nostro tempo non importa dell'eternità. È dalla parte del calcolo e dell'istante. La settimana prossima è già fuori dalla sua portata di significato. Ora, il teatro mostra come ogni misura reale del tempo implichi una presentazione dell'atemporale. Il teatro esibisce la connessione massima, quella dell'istante con l'eternità. Costruisce il proprio tempo, nel momento in cui noi sopportiamo la banalità del nostro. Il teatro ci dice che per sapere chi siamo, dove siamo, e quanto vale il nostro tempo, abbiamo bisogno di Amleto, di Antigone, del costruttore Solness, di Berenice, di Galileo, la cui esistenza atemporale è garantita dalla temporalità sperimentale e dalla singolarità dell’evento teatrale" (Alain Badiou).

Porphyrins are an important class of natural and artificial pigments which play an important role in largely different area of both fundamental and technological interest. In particular, porphyrin metal derivatives have been exploited as models for enzymes and artificial blood. Charged porphyrins are able to interact with several relevant biomolecules, i.e., nucleic acids, polypeptides, and proteins. This property together with their ability to localize into tumor cells and to photosensitize the production of singlet oxygen led to the development of several compounds actually in use or under investigation for photodynamic therapy applications (PDT) [1]. Interestingly, quite recently, meso-tetrakis(4-carboxyphenyl) porphyrin (TPPC) and its derivatives have been exploited as a marker for the rapid detection of tumor cells by fluorescence imaging. A common feature of these molecules is their propensity to interact to form dimers, oligomers, or more extended aggregates. To develop efficient systems for biomedical applications or for PDT (in which aggregation should be prevented) or to stabilize monomeric porphyrins in a very water-soluble form, novel systems based on biocompatible delivery systems are highly desirable. In this framework, recently some of us reported on the employment of biocompatible amino-terminated polypropylene or poly(ethylene oxide)s generally termed as Jeffamines, to prevent porphyrin aggregation, allowing to reach millimolar concentration of TPPC in a monomeric form in solution [2]. In biological media, cell membranes seem to be important targets for many antineoplastic photosensitizer agents. Red blood cells have been often used for in vitro PDT studies. Here we report on two different porphyrin derivatives, TPPC-Jeff and ZnTPPC-Jeff. Photodynamic action was then evaluated in vitro using human red blood (HRB) cells under different conditions to obtain information about the effect produced by these porphyrin derivatives. The morphology of erythrocytes has been investigated by optical microscopy after incubation with porphyrin compounds and irradiation having a losing of their normal biconcave profile and an incoming of a spiny configuration with blebs in their surfaces. Further studies are required to optimize potential therapeutic dosing strategies to inform and encourage clinical trial design.

Spectroscopic characterization and in vitro assay on human blood of novel porphyrin derivatives

Analisi del percorso estetico di Romeo Castellucci