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54. Eligibility for Liver Transplantation in Patients with Perihilar Cholangiocarcinoma

Author

Vugts, Jaynee J. A., primary, Gaspersz, Marcia P., additional, Roos, Eva, additional, Franken, Lotte C., additional, Olthof, Pim B., additional, Coelen, Robert J. S., additional, van Vugt, Jeroen L. A., additional, Labeur, Tim A., additional, Brouwer, Lieke, additional, Besselink, Marc G. H., additional, IJzermans, Jan N. M., additional, Darwish Murad, Sarwa, additional, van Gulik, Thomas M., additional, de Jonge, Jeroen, additional, Polak, Wojciech G., additional, Busch, Olivier R. C., additional, Erdmann, Joris L., additional, Groot Koerkamp, Bas, additional, and Buettner, Stefan, additional

Published
2020
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57. Added value of 3D-vision during laparoscopic biotissue pancreatico- and hepaticojejunostomy (LAELAPS 3D2D): an international randomized cross-over trial

Author

Zwart, Maurice J. W., Fuente, Ignacio, Hilst, Jony, de Rooij, Thijs, van Dieren, Susan, van Rijssen, Lennart B., Schijven, Marlies P., Busch, Olivier R. C., Luyer, Misha D., Lips, Daan J., Festen, Sebastiaan, Abu Hilal, Mohammed, Besselink, Marc G., Stibbe, L. A., AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Graduate School, AGEM - Re-generation and cancer of the digestive system, AGEM - Endocrinology, metabolism and nutrition, AGEM - Digestive immunity, CCA - Imaging and biomarkers, Surgery, APH - Methodology, Ear, Nose and Throat, APH - Digital Health, and APH - Quality of Care

Subjects
Adult, Male, medicine.medical_specialty, Internationality, Operative Time, Anastomosis, Risk Assessment, Biliary surgery, 3d vision, Imaging, Three-Dimensional, Pancreatectomy, Pancreaticojejunostomy, Task Performance and Analysis, Clinical endpoint, medicine, Hepatectomy, Humans, Technical skills, Laparoscopy, Aged, Observer Variation, Surgeons, Cross-Over Studies, Intraoperative Care, Hepatology, medicine.diagnostic_test, business.industry, General surgery, Anastomosis, Surgical, Gastroenterology, Internship and Residency, Middle Aged, Prognosis, Crossover study, Treatment Outcome, Operative time, Female, Clinical Competence, business
Abstract

Background It is currently unclear what the added value is of 3D-laparoscopy during pancreatic and biliary surgery. 3D-laparoscopy could improve procedure time and/or surgical performance, for instance in demanding anastomoses such as pancreatico- and hepaticojejunostomy. The impact of 3D-laparoscopy could be negligible in more experienced surgeons. Methods We conducted a randomized controlled cross-over trial including 20 expert laparoscopic surgeons and 20 surgical residents from 9 countries (Argentina, Estonia, Israel, Italy, the Netherlands, South Africa, Spain, UK, USA). All participants performed a pancreaticojejunostomy (PJ) and a hepaticojejunostomy (HJ) using 3D- and 2D-laparoscopy on biotissue organ models according to the Pittsburgh method. Primary endpoint was the time required to complete both anastomoses. Secondary endpoint was the objective structured assessment of technical skill (OSATS; range 12–60) rating. Observers were blinded for 3D/2D and expertise. Results A total of 40 participants completed 144 PJs and HJs. 3D-laparoscopy reduced the operative time with 15.5 min (95%CI 10.2–24.5 min), from 81.0 to 64.4 min, p = 0.001. This reduction was observed for both experts and residents (13.0 vs 22.2 min, intergroup significance p = 0.354). The OSATS improved with 5.1 points, SD ± 6.3, with 3D-laparoscopy, p = 0.001. This improvement was observed for both experts and residents (4.6 vs 5.6 points, p = 0.519). Of all participants, 37/39 participants stated to prefer 3D laparoscopy whereas 14/39 reported side effects. Minor side effects were reported by 10/39 participants whereas 2/39 participants reported severe side effects (both severe eye strain). Conclusion 3D-laparoscopy, as compared to 2D-laparoscopy, reduced the operative time and improved surgical performance for PJ and HJ anastomoses in both experts and residents with mostly minor side effects.

Published
2019

59. Postpancreatectomy Acute Pancreatitis (PPAP)

Author

Marchegiani, Giovanni, Barreto, Savio George, Bannone, Elisa, Sarr, Michael, Vollmer, Charles M., Connor, Saxon, Falconi, Massimo, Besselink, Marc G., Salvia, Roberto, Wolfgang, Christopher L., Zyromski, Nicholas J., Yeo, Charles J., Adham, Mustapha, Siriwardena, Ajith K., Takaori, Kyoichi, Hilal, Mohammad Abu, Loos, Martin, Probst, Pascal, Hackert, Thilo, Strobel, Oliver, Busch, Olivier R. C., Lillemoe, Keith D., Miao, Yi, Halloran, Christopher M., Werner, Jens, Friess, Helmut, Izbicki, Jakob R., Bockhorn, Maximillian, Vashist, Yogesh K., Conlon, Kevin, Passas, Ioannis, Gianotti, Luca, Del Chiaro, Marco, Schulick, Richard D., Montorsi, Marco, Oláh, Attila, Fusai, Giuseppe Kito, Serrablo, Alejandro, Zerbi, Alessandro, Fingerhut, Abe, Andersson, Roland, Padbury, Robert, Dervenis, Christos, Neoptolemos, John P., Bassi, Claudio, Büchler, Markus W., and Shrikhande, Shailesh V.

Published
2022
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60. Added value of 3D-vision during robotic pancreatoduodenectomy anastomoses in biotissue (LAEBOT 3D2D): a randomized controlled cross-over trial.

Author

Zwart, Maurice J. W., Jones, Leia R., Balduzzi, Alberto, Takagi, Kosei, Vanlander, Aude, van den Boezem, Peter B., Daams, Freek, Rosman, Camiel, Lips, Daan J., Moser, Arthur J., Hogg, Melissa E., Busch, Olivier R. C., Stommel, Martijn W. J., and Besselink, Marc G.

Subjects
RANDOMIZED controlled trials, PANCREATICODUODENECTOMY, SURGICAL robots, OPERATIVE surgery, ROBOTICS
Abstract

Background: We tested the added value of 3D-vision on procedure time and surgical performance during robotic pancreatoduodenectomy anastomoses in biotissue. Robotic surgery has the advantage of articulating instruments and 3D-vision. Consensus is lacking on the added value of 3D-vision during laparoscopic surgery. Given the improved dexterity with robotic surgery, the added value of 3D-vision may be even less with robotic surgery. Methods: In this experimental randomized controlled cross-over trial, 20 surgeons and surgical residents from 5 countries performed robotic pancreaticojejunostomy and hepaticojejunostomy anastomoses in a biotissue organ model using the da Vinci® system and were randomized to start with either 3D- or 2D-vision. Primary endpoint was the time required to complete both anastomoses. Secondary endpoint was the objective structured assessment of technical skill (OSATS; range 12–60) rating; scored by two observers blinded to 3D/2D. Results: Robotic 3D-vision reduced the combined operative time from 78.1 to 57.3 min (24.6% reduction, p < 0.001; 20.8 min reduction, 95% confidence intervals 12.8–28.8 min). This reduction was consistent for both anastomoses and between surgeons and residents, p < 0.001. Robotic 3D-vision improved OSATS performance by 6.1 points (20.8% improvement, p = 0.003) compared to 2D (39.4 to 45.1 points, ± 5.5). Conclusion: 3D-vision has a considerable added value during robotic pancreatoduodenectomy anastomoses in biotissue in both time reduction and improved surgical performance as compared to 2D-vision. [ABSTRACT FROM AUTHOR]

Published
2021
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62. Long-term yield of pancreatic cancer surveillance in high-risk individuals

Author

Overbeek, Kasper A, Levink, Iris J M, Koopmann, Brechtje D M, Harinck, Femme, Konings, Ingrid C A W, Ausems, Margreet G E M, Wagner, Anja, Fockens, Paul, van Eijck, Casper H, Groot Koerkamp, Bas, Busch, Olivier R C, Besselink, Marc G, Bastiaansen, Barbara A J, van Driel, Lydi M J W, Erler, Nicole S, Vleggaar, Frank P, Poley, Jan-Werner, Cahen, Djuna L, van Hooft, Jeanin E, and Bruno, Marco J

Abstract

ObjectiveWe aimed to determine the long-term yield of pancreatic cancer surveillance in hereditary predisposed high-risk individuals.DesignFrom 2006 to 2019, we prospectively enrolled asymptomatic individuals with an estimated 10% or greater lifetime risk of pancreatic ductal adenocarcinoma (PDAC) after obligatory evaluation by a clinical geneticist and genetic testing, and subjected them to annual surveillance with both endoscopic ultrasonography (EUS) and MRI/cholangiopancreatography (MRI/MRCP) at each visit.Results366 individuals (201 mutation-negative familial pancreatic cancer (FPC) kindreds and 165 PDAC susceptibility gene mutation carriers; mean age 54 years, SD 9.9) were followed for 63 months on average (SD 43.2). Ten individuals developed PDAC, of which four presented with a symptomatic interval carcinoma and six underwent resection. The cumulative PDAC incidence was 9.3% in the mutation carriers and 0% in the FPC kindreds (p<0.001). Median PDAC survival was 18 months (range 1–32). Surgery was performed in 17 individuals (4.6%), whose pathology revealed 6 PDACs (3 T1N0M0), 7 low-grade precursor lesions, 2 neuroendocrine tumours <2 cm, 1 autoimmune pancreatitis and in 1 individual no abnormality. There was no surgery-related mortality. EUS detected more solid lesions than MRI/MRCP (100% vs 22%, p<0.001), but less cystic lesions (42% vs 83%, p<0.001).ConclusionThe diagnostic yield of PDAC was substantial in established high-risk mutation carriers, but non-existent in the mutation-negative proven FPC kindreds. Nevertheless, timely identification of resectable lesions proved challenging despite the concurrent use of two imaging modalities, with EUS outperforming MRI/MRCP. Overall, surveillance by imaging yields suboptimal results with a clear need for more sensitive diagnostic markers, including biomarkers.

Published
2022
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64. Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation

Author

Campa, Daniele, Pastore, Manuela, Capurso, Gabriele, Hackert, Thilo, Di Leo, Milena, Izbicki, Jakob R., Khaw, Kay Tee, Gioffreda, Domenica, Kupcinskas, Juozas, Pasquali, Claudio, Macinga, Peter, Kaaks, Rudolf, Stigliano, Serena, Peeters, Petra H., Key, Timothy J., Talar-Wojnarowska, Renata, Vodicka, Pavel, Valente, Roberto, Vashist, Yogesh K., Salvia, Roberto, Papaconstantinou, Ioannis, Shimizu, Yasuhiro, Valsuani, Chiara, Zambon, Carlo Federico, Gazouli, Maria, Valantiene, Irena, Niesen, Willem, Mohelnikova-Duchonova, Beatrice, Hara, Kazuo, Soucek, Pavel, Malecka-Panas, Ewa, Bueno-de-Mesquita, H. Bas, Johnson, Theron, Brenner, Herman, Tavano, Francesca, Fogar, Paola, Ito, Hidemi, Sperti, Cosimo, Butterbach, Katja, Latiano, Anna, Andriulli, Angelo, Cavestro, Giulia Martina, Busch, Olivier R C, Dijk, Frederike, Greenhalf, William, Matsuo, Keitaro, Lombardo, Carlo, Strobel, Oliver, König, Anna Katharina, Cuk, Katarina, Strothmann, Hendrik, Katzke, Verena, Cantore, Maurizio, Mambrini, Andrea, Oliverius, Martin, Pezzilli, Raffaele, Landi, Stefano, Canzian, Federico, Campa, Daniele, Pastore, Manuela, Capurso, Gabriele, Hackert, Thilo, Di Leo, Milena, Izbicki, Jakob R., Khaw, Kay Tee, Gioffreda, Domenica, Kupcinskas, Juozas, Pasquali, Claudio, Macinga, Peter, Kaaks, Rudolf, Stigliano, Serena, Peeters, Petra H., Key, Timothy J., Talar-Wojnarowska, Renata, Vodicka, Pavel, Valente, Roberto, Vashist, Yogesh K., Salvia, Roberto, Papaconstantinou, Ioannis, Shimizu, Yasuhiro, Valsuani, Chiara, Zambon, Carlo Federico, Gazouli, Maria, Valantiene, Irena, Niesen, Willem, Mohelnikova-Duchonova, Beatrice, Hara, Kazuo, Soucek, Pavel, Malecka-Panas, Ewa, Bueno-de-Mesquita, H. Bas, Johnson, Theron, Brenner, Herman, Tavano, Francesca, Fogar, Paola, Ito, Hidemi, Sperti, Cosimo, Butterbach, Katja, Latiano, Anna, Andriulli, Angelo, Cavestro, Giulia Martina, Busch, Olivier R C, Dijk, Frederike, Greenhalf, William, Matsuo, Keitaro, Lombardo, Carlo, Strobel, Oliver, König, Anna Katharina, Cuk, Katarina, Strothmann, Hendrik, Katzke, Verena, Cantore, Maurizio, Mambrini, Andrea, Oliverius, Martin, Pezzilli, Raffaele, Landi, Stefano, and Canzian, Federico

Published
2018

65. Endoscopic versus percutaneous biliary drainage in patients with resectable perihilar cholangiocarcinoma: a multicentre, randomised controlled trial

Author

Coelen, Robert J. S., Coelen, Robert J. S., Roos, Eva, Wiggers, Jimme K., Besselink, Marc G., Buis, Carlijn I., Busch, Olivier R. C., Dejong, Cornelis H. C., van Delden, Otto M., van Eijck, Casper H. J., Fockens, Paul, Gouma, Dirk J., Koerkamp, Bas Groot, de Haan, Michiel W., van Hooft, Jeanin E., IJzermans, Jan N. M., Kater, G. Matthijs, Koornstra, Jan J., van Lienden, Krijn P., Moelker, Adriaan, Damink, Steven W. M. Olde, Poley, Jan-Werner, Porte, Robert J., de Ridder, Rogier J., Verheij, Joanne, van Woerden, Victor, Rauws, Erik A. J., Dijkgraaf, Marcel G. W., van Gulik, Thomas M., Coelen, Robert J. S., Coelen, Robert J. S., Roos, Eva, Wiggers, Jimme K., Besselink, Marc G., Buis, Carlijn I., Busch, Olivier R. C., Dejong, Cornelis H. C., van Delden, Otto M., van Eijck, Casper H. J., Fockens, Paul, Gouma, Dirk J., Koerkamp, Bas Groot, de Haan, Michiel W., van Hooft, Jeanin E., IJzermans, Jan N. M., Kater, G. Matthijs, Koornstra, Jan J., van Lienden, Krijn P., Moelker, Adriaan, Damink, Steven W. M. Olde, Poley, Jan-Werner, Porte, Robert J., de Ridder, Rogier J., Verheij, Joanne, van Woerden, Victor, Rauws, Erik A. J., Dijkgraaf, Marcel G. W., and van Gulik, Thomas M.

Abstract

Background In patients with resectable perihilar cholangiocarcinoma, biliary drainage is recommended to treat obstructive jaundice and optimise the clinical condition before liver resection. Little evidence exists on the preferred initial method of biliary drainage. We therefore investigated the incidence of severe drainage-related complications of endoscopic biliary drainage or percutaneous transhepatic biliary drainage in patients with potentially resectable perihilar cholangiocarcinoma.Methods We did a multicentre, randomised controlled trial at four academic centres in the Netherlands. Patients who were aged at least 18 years with potentially resectable perihilar cholangiocarcinoma requiring major liver resection, and biliary obstruction of the future liver remnant (defined as a bilirubin concentration of >50 mu mol/L [2.9 mg/dL]), were randomly assigned (1:1) to receive endoscopic biliary drainage or percutaneous transhepatic biliary drainage through the use of computer-generated allocation. Randomisation, done by the trial coordinator, was stratified for previous (attempted) biliary drainage, the extent of bile duct involvement, and enrolling centre. Patients were enrolled by clinicians of the participating centres. The primary outcome was the number of severe complications between randomisation and surgery in the intention-to-treat population. The trial was registered at the Netherlands National Trial Register, number NTR4243.Findings From Sept 26, 2013, to April 29, 2016, 261 patients were screened for participation, and 54 eligible patients were randomly assigned to endoscopic biliary drainage (n=27) or percutaneous transhepatic biliary drainage (n=27). The study was prematurely closed because of higher mortality in the percutaneous transhepatic biliary drainage group (11 [41%] of 27 patients) than in the endoscopic biliary drainage group (three [11%] of 27 patients; relative risk 3.67, 95% CI 1.15-11.69; p=0.03). Three of the 11 deaths

Published
2018

66. Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation

Author

Epi Kanker Team B, UMC Utrecht, Cancer, JC onderzoeksprogramma Kanker, MS MDL 1, Campa, Daniele, Pastore, Manuela, Capurso, Gabriele, Hackert, Thilo, Di Leo, Milena, Izbicki, Jakob R., Khaw, Kay Tee, Gioffreda, Domenica, Kupcinskas, Juozas, Pasquali, Claudio, Macinga, Peter, Kaaks, Rudolf, Stigliano, Serena, Peeters, Petra H., Key, Timothy J., Talar-Wojnarowska, Renata, Vodicka, Pavel, Valente, Roberto, Vashist, Yogesh K., Salvia, Roberto, Papaconstantinou, Ioannis, Shimizu, Yasuhiro, Valsuani, Chiara, Zambon, Carlo Federico, Gazouli, Maria, Valantiene, Irena, Niesen, Willem, Mohelnikova-Duchonova, Beatrice, Hara, Kazuo, Soucek, Pavel, Malecka-Panas, Ewa, Bueno-de-Mesquita, H. Bas, Johnson, Theron, Brenner, Herman, Tavano, Francesca, Fogar, Paola, Ito, Hidemi, Sperti, Cosimo, Butterbach, Katja, Latiano, Anna, Andriulli, Angelo, Cavestro, Giulia Martina, Busch, Olivier R C, Dijk, Frederike, Greenhalf, William, Matsuo, Keitaro, Lombardo, Carlo, Strobel, Oliver, König, Anna Katharina, Cuk, Katarina, Strothmann, Hendrik, Katzke, Verena, Cantore, Maurizio, Mambrini, Andrea, Oliverius, Martin, Pezzilli, Raffaele, Landi, Stefano, Canzian, Federico, Epi Kanker Team B, UMC Utrecht, Cancer, JC onderzoeksprogramma Kanker, MS MDL 1, Campa, Daniele, Pastore, Manuela, Capurso, Gabriele, Hackert, Thilo, Di Leo, Milena, Izbicki, Jakob R., Khaw, Kay Tee, Gioffreda, Domenica, Kupcinskas, Juozas, Pasquali, Claudio, Macinga, Peter, Kaaks, Rudolf, Stigliano, Serena, Peeters, Petra H., Key, Timothy J., Talar-Wojnarowska, Renata, Vodicka, Pavel, Valente, Roberto, Vashist, Yogesh K., Salvia, Roberto, Papaconstantinou, Ioannis, Shimizu, Yasuhiro, Valsuani, Chiara, Zambon, Carlo Federico, Gazouli, Maria, Valantiene, Irena, Niesen, Willem, Mohelnikova-Duchonova, Beatrice, Hara, Kazuo, Soucek, Pavel, Malecka-Panas, Ewa, Bueno-de-Mesquita, H. Bas, Johnson, Theron, Brenner, Herman, Tavano, Francesca, Fogar, Paola, Ito, Hidemi, Sperti, Cosimo, Butterbach, Katja, Latiano, Anna, Andriulli, Angelo, Cavestro, Giulia Martina, Busch, Olivier R C, Dijk, Frederike, Greenhalf, William, Matsuo, Keitaro, Lombardo, Carlo, Strobel, Oliver, König, Anna Katharina, Cuk, Katarina, Strothmann, Hendrik, Katzke, Verena, Cantore, Maurizio, Mambrini, Andrea, Oliverius, Martin, Pezzilli, Raffaele, Landi, Stefano, and Canzian, Federico

Published
2018

69. Minimally invasive versus open distal pancreatectomy (LEOPARD) : study protocol for a randomized controlled trial

Author

de Rooij, Thijs, van Hilst, Jony, Vogel, Jantien A, van Santvoort, Hjalmar C, de Boer, Marieke T., Boerma, Djamila, van den Boezem, Peter B., Bonsing, Bert A., Bosscha, Koop, Coene, Peter-Paul, Daams, Freek, van Dam, Ronald M., Dijkgraaf, Marcel G. W., van Eijck, Casper H., Festen, Sebastiaan, Gerhards, Michael F., Groot Koerkamp, Bas, Hagendoorn, Jeroen, van der Harst, Erwin, de Hingh, Ignace H., Dejong, Cees H., Kazemier, Geert, Klaase, Joost M., de Kleine, Ruben H J, van Laarhoven, Cornelis J., Lips, Daan J., Luyer, Misha Dp, Molenaar, I Quintus, Nieuwenhuijs, Vincent B., Patijn, Gijs A., Roos, Daphne, Scheepers, Joris Jg, Van Der Schelling, George P., Steenvoorde, Pascal, Swijnenburg, Rutger-Jan, Wijsman, Jan H, Abu Hilal, Moh'd, Busch, Olivier R C, Besselink, Marc G H, Dutch Pancreatic Cancer Group, de Rooij, Thijs, van Hilst, Jony, Vogel, Jantien A, van Santvoort, Hjalmar C, de Boer, Marieke T., Boerma, Djamila, van den Boezem, Peter B., Bonsing, Bert A., Bosscha, Koop, Coene, Peter-Paul, Daams, Freek, van Dam, Ronald M., Dijkgraaf, Marcel G. W., van Eijck, Casper H., Festen, Sebastiaan, Gerhards, Michael F., Groot Koerkamp, Bas, Hagendoorn, Jeroen, van der Harst, Erwin, de Hingh, Ignace H., Dejong, Cees H., Kazemier, Geert, Klaase, Joost M., de Kleine, Ruben H J, van Laarhoven, Cornelis J., Lips, Daan J., Luyer, Misha Dp, Molenaar, I Quintus, Nieuwenhuijs, Vincent B., Patijn, Gijs A., Roos, Daphne, Scheepers, Joris Jg, Van Der Schelling, George P., Steenvoorde, Pascal, Swijnenburg, Rutger-Jan, Wijsman, Jan H, Abu Hilal, Moh'd, Busch, Olivier R C, Besselink, Marc G H, and Dutch Pancreatic Cancer Group

Published
2017

70. Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial

Author

MS CGO, Cancer, de Rooij, Thijs, van Hilst, Jony, Vogel, Jantien A, van Santvoort, Hjalmar C, de Boer, Marieke T., Boerma, Djamila, van den Boezem, Peter B., Bonsing, Bert A., Bosscha, Koop, Coene, Peter-Paul, Daams, Freek, van Dam, Ronald M., Dijkgraaf, Marcel G. W., van Eijck, Casper H., Festen, Sebastiaan, Gerhards, Michael F., Groot Koerkamp, Bas, Hagendoorn, Jeroen, van der Harst, Erwin, de Hingh, Ignace H., Dejong, Cees H., Kazemier, Geert, Klaase, Joost M., de Kleine, Ruben H J, van Laarhoven, Cornelis J., Lips, Daan J., Luyer, Misha Dp, Molenaar, I Quintus, Nieuwenhuijs, Vincent B., Patijn, Gijs A., Roos, Daphne, Scheepers, Joris Jg, Van Der Schelling, George P., Steenvoorde, Pascal, Swijnenburg, Rutger-Jan, Wijsman, Jan H, Abu Hilal, Moh'd, Busch, Olivier R C, Besselink, Marc G H, Dutch Pancreatic Cancer Group, MS CGO, Cancer, de Rooij, Thijs, van Hilst, Jony, Vogel, Jantien A, van Santvoort, Hjalmar C, de Boer, Marieke T., Boerma, Djamila, van den Boezem, Peter B., Bonsing, Bert A., Bosscha, Koop, Coene, Peter-Paul, Daams, Freek, van Dam, Ronald M., Dijkgraaf, Marcel G. W., van Eijck, Casper H., Festen, Sebastiaan, Gerhards, Michael F., Groot Koerkamp, Bas, Hagendoorn, Jeroen, van der Harst, Erwin, de Hingh, Ignace H., Dejong, Cees H., Kazemier, Geert, Klaase, Joost M., de Kleine, Ruben H J, van Laarhoven, Cornelis J., Lips, Daan J., Luyer, Misha Dp, Molenaar, I Quintus, Nieuwenhuijs, Vincent B., Patijn, Gijs A., Roos, Daphne, Scheepers, Joris Jg, Van Der Schelling, George P., Steenvoorde, Pascal, Swijnenburg, Rutger-Jan, Wijsman, Jan H, Abu Hilal, Moh'd, Busch, Olivier R C, Besselink, Marc G H, and Dutch Pancreatic Cancer Group

Published
2017

71. Hospital of diagnosis and likelihood of surgical treatment for pancreatic cancer

Author

Bakens, M. J A M, van Gestel, Yvette R B M, Bongers, M., Besselink, Marc G H, Dejong, C.H.C., Molenaar, I. Q., Busch, Olivier R C, Lemmens, Valery E. P. P., de Hingh, Ignace H J T, and the Dutch Pancreatic Cancer Group

Subjects
Surgery
Abstract

Background: Surgical resection for pancreatic cancer offers the only chance of cure. Assessment of the resectability of a pancreatic tumour is therefore of great importance. The aim of the study was to investigate whether centre of diagnosis influences the likelihood of surgery and whether this affects long-term survival. Methods: Patients diagnosed with non-metastasized pancreatic cancer (M0) between 2005 and 2013 in the Netherlands were selected from the Netherlands Cancer Registry. Hospitals were classified as a pancreatic centre (at least 20 resections/year) or a non-pancreatic centre (fewer than 20 resections/year). The relationship between centre of diagnosis and likelihood of surgery was analysed by multivariable logistic regression. Influence of centre on overall survival was assessed by means of multivariable Cox regression analysis. Results: Some 8141 patients were diagnosed with non-metastasized pancreatic cancer, of whom 3123 (38·4 per cent) underwent surgery. Of the 2712 patients diagnosed in one of 19 pancreatic centres, 52·4 per cent had exploratory laparotomy compared with 31·4 per cent of 5429 patients diagnosed in one of 74 non-pancreatic centres (P < 0·001). A pancreatectomy was performed in 42·8 and 24·6 per cent of the patients respectively (P < 0·001). Multivariable analysis revealed that patients diagnosed in a pancreatic centre had a higher chance of undergoing surgery (odds ratio 2·21, 95 per cent c.i. 1·98 to 2·47). Centre of diagnosis was not associated with improved long-term survival (hazard ratio 0·95, 95 per cent c.i. 0·91 to 1·00). Conclusion: Patients with non-metastasized pancreatic cancer had a greater likelihood of having surgical treatment when the diagnosis was established in a pancreatic centre.

Published
2015

72. Ablation with irreversible electroporation in patients with advanced perihilar cholangiocarcinoma (ALPACA): a multicentre phase I/II feasibility study protocol

Author

Coelen, Robert J S, primary, Vogel, Jantien A, additional, Vroomen, Laurien G P H, additional, Roos, Eva, additional, Busch, Olivier R C, additional, van Delden, Otto M, additional, Delft, Foke van, additional, Heger, Michal, additional, van Hooft, Jeanin E, additional, Kazemier, Geert, additional, Klümpen, Heinz-Josef, additional, van Lienden, Krijn P, additional, Rauws, Erik A J, additional, Scheffer, Hester J, additional, Verheul, Henk M, additional, Vries, Jan de, additional, Wilmink, Johanna W, additional, Zonderhuis, Barbara M, additional, Besselink, Marc G, additional, van Gulik, Thomas M, additional, and Meijerink, Martijn R, additional

Published
2017
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75. Case on CDB lesion during laparoscopic cholesystectomy

Author

Busch, Olivier R. C., Booij, Klaske A. C., Gouma, Dirk J., van Gulik, Thomas M., Cuesta, Miguel A., Bonjer, H. Jaap, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Surgery, Graduate School, and Plastic, Reconstructive and Hand Surgery

Published
2014

78. A nationwide comparison of laparoscopic and open distal pancreatectomy for benign and malignant disease

Author

de Rooij, Thijs, Jilesen, Anneke P., Boerma, Djamila, Bonsing, Bert A., Bosscha, Koop, van Dam, Ronald M., Van Dieren, Susan, Dijkgraaf, Marcel G. W., van Eijck, Casper H., Gerhards, Michael F., van Goor, Harry, van der Harst, Erwin, de Hingh, Ignace H., Kazemier, Geert, Klaase, Joost M., Molenaar, I. Quintus, Nieveen van Dijkum, Els J M, Patijn, Gijs A., Van Santvoort, Hjalmar C., Scheepers, Joris Jg, Van Der Schelling, George P., Sieders, Egbert, Vogel, Jantien A, Busch, Olivier R C, Besselink, Marc G H, de Rooij, Thijs, Jilesen, Anneke P., Boerma, Djamila, Bonsing, Bert A., Bosscha, Koop, van Dam, Ronald M., Van Dieren, Susan, Dijkgraaf, Marcel G. W., van Eijck, Casper H., Gerhards, Michael F., van Goor, Harry, van der Harst, Erwin, de Hingh, Ignace H., Kazemier, Geert, Klaase, Joost M., Molenaar, I. Quintus, Nieveen van Dijkum, Els J M, Patijn, Gijs A., Van Santvoort, Hjalmar C., Scheepers, Joris Jg, Van Der Schelling, George P., Sieders, Egbert, Vogel, Jantien A, Busch, Olivier R C, and Besselink, Marc G H

Published
2015

79. Diagnostic value of a pancreatic mass on computed tomography in patients undergoing pancreatoduodenectomy for presumed pancreatic cancer

Author

Gerritsen, Arja, Bollen, Thomas L., Nio, C. Yung, Molenaar, I. Quintus, Dijkgraaf, Marcel G W, van Santvoort, Hjalmar C., Offerhaus, G. Johan, Brosens, Lodewijk A., Biermann, Katharina, Sieders, Egbert, de Jong, Koert P., van Dam, Ronald M., van der Harst, Erwin, van Goor, Harry, van Ramshorst, Bert, Bonsing, Bert A., de Hingh, Ignace H., Gerhards, Michael F., van Eijck, Casper H., Gouma, Dirk J., Borel Rinkes, IHM, Busch, Olivier R C, Besselink, Marc G H, Gerritsen, Arja, Bollen, Thomas L., Nio, C. Yung, Molenaar, I. Quintus, Dijkgraaf, Marcel G W, van Santvoort, Hjalmar C., Offerhaus, G. Johan, Brosens, Lodewijk A., Biermann, Katharina, Sieders, Egbert, de Jong, Koert P., van Dam, Ronald M., van der Harst, Erwin, van Goor, Harry, van Ramshorst, Bert, Bonsing, Bert A., de Hingh, Ignace H., Gerhards, Michael F., van Eijck, Casper H., Gouma, Dirk J., Borel Rinkes, IHM, Busch, Olivier R C, and Besselink, Marc G H

Published
2015

80. A nationwide comparison of laparoscopic and open distal pancreatectomy for benign and malignant disease

Author

Perfusie, UMC Utrecht, MS CGO, Cancer, de Rooij, Thijs, Jilesen, Anneke P., Boerma, Djamila, Bonsing, Bert A., Bosscha, Koop, van Dam, Ronald M., Van Dieren, Susan, Dijkgraaf, Marcel G. W., van Eijck, Casper H., Gerhards, Michael F., van Goor, Harry, van der Harst, Erwin, de Hingh, Ignace H., Kazemier, Geert, Klaase, Joost M., Molenaar, I. Quintus, Nieveen van Dijkum, Els J M, Patijn, Gijs A., Van Santvoort, Hjalmar C., Scheepers, Joris Jg, Van Der Schelling, George P., Sieders, Egbert, Vogel, Jantien A, Busch, Olivier R C, Besselink, Marc G H, Perfusie, UMC Utrecht, MS CGO, Cancer, de Rooij, Thijs, Jilesen, Anneke P., Boerma, Djamila, Bonsing, Bert A., Bosscha, Koop, van Dam, Ronald M., Van Dieren, Susan, Dijkgraaf, Marcel G. W., van Eijck, Casper H., Gerhards, Michael F., van Goor, Harry, van der Harst, Erwin, de Hingh, Ignace H., Kazemier, Geert, Klaase, Joost M., Molenaar, I. Quintus, Nieveen van Dijkum, Els J M, Patijn, Gijs A., Van Santvoort, Hjalmar C., Scheepers, Joris Jg, Van Der Schelling, George P., Sieders, Egbert, Vogel, Jantien A, Busch, Olivier R C, and Besselink, Marc G H

Published
2015

81. Hospital of diagnosis and likelihood of surgical treatment for pancreatic cancer

Author

CTC, MS CGO, Cancer, Bakens, M. J A M, van Gestel, Yvette R B M, Bongers, M., Besselink, Marc G H, Dejong, C.H.C., Molenaar, I. Q., Busch, Olivier R C, Lemmens, Valery E. P. P., de Hingh, Ignace H J T, the Dutch Pancreatic Cancer Group, CTC, MS CGO, Cancer, Bakens, M. J A M, van Gestel, Yvette R B M, Bongers, M., Besselink, Marc G H, Dejong, C.H.C., Molenaar, I. Q., Busch, Olivier R C, Lemmens, Valery E. P. P., de Hingh, Ignace H J T, and the Dutch Pancreatic Cancer Group

Published
2015

82. Diagnostic value of a pancreatic mass on computed tomography in patients undergoing pancreatoduodenectomy for presumed pancreatic cancer

Author

Cancer, MS CGO, Zorgeenheid Heelkunde Medisch, Pathologie Pathologen staf, Divisie Beeld & Oncologie, Gerritsen, Arja, Bollen, Thomas L., Nio, C. Yung, Molenaar, I. Quintus, Dijkgraaf, Marcel G W, van Santvoort, Hjalmar C., Offerhaus, G. Johan, Brosens, Lodewijk A., Biermann, Katharina, Sieders, Egbert, de Jong, Koert P., van Dam, Ronald M., van der Harst, Erwin, van Goor, Harry, van Ramshorst, Bert, Bonsing, Bert A., de Hingh, Ignace H., Gerhards, Michael F., van Eijck, Casper H., Gouma, Dirk J., Borel Rinkes, IHM, Busch, Olivier R C, Besselink, Marc G H, Cancer, MS CGO, Zorgeenheid Heelkunde Medisch, Pathologie Pathologen staf, Divisie Beeld & Oncologie, Gerritsen, Arja, Bollen, Thomas L., Nio, C. Yung, Molenaar, I. Quintus, Dijkgraaf, Marcel G W, van Santvoort, Hjalmar C., Offerhaus, G. Johan, Brosens, Lodewijk A., Biermann, Katharina, Sieders, Egbert, de Jong, Koert P., van Dam, Ronald M., van der Harst, Erwin, van Goor, Harry, van Ramshorst, Bert, Bonsing, Bert A., de Hingh, Ignace H., Gerhards, Michael F., van Eijck, Casper H., Gouma, Dirk J., Borel Rinkes, IHM, Busch, Olivier R C, and Besselink, Marc G H

Published
2015

85. Staging and assessment of hepatobiliary malignancies

Author

de Castro, Steve M. M., van Delden, Otto M., Gouma, Dirk J., Busch, Olivier R. C., Garden, O. J., Parks, R. W., Amsterdam Cardiovascular Sciences, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Radiology and Nuclear Medicine, and Surgery

Published
2013

86. Preoperative biliary drainage

Author

Ruys, Anthony T., Rauws, Eric A. J., Busch, Olivier R. C., Laméris, J. S., Gouma, Dirk J., van Gulik, Thomas M., Lau, W. Y., Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Gastroenterology and Hepatology, Surgery, and Radiology and Nuclear Medicine

Published
2013

87. Feasibility and effectiveness of pre-operative inspiratory muscle training in patients undergoing oesophagectomy: a pilot study

Author

Dettling, Daniela S., van der Schaaf, Marike, Blom, Rachel L. G. M., Nollet, Frans, Busch, Olivier R. C., van Berge Henegouwen, Mark I., Graduate School, Amsterdam Movement Sciences, Rehabilitation medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, and Surgery

Abstract

Patients undergoing oesophageal surgery have a high risk for post-operative complications including pulmonary infections. Recently, physical therapy has shifted from the post-operative to the pre-operative phase to diminish post-operative complications and to shorten hospital stay. The purpose of this pilot study was to investigate the feasibility and initial effectiveness of pre-operative inspiratory muscle training (IMT) on the incidence of pneumonia in patients undergoing oesophagectomy. A pragmatic non-randomized controlled trial was conducted among all patients who underwent an oesophagectomy between January 2009 and February 2010. Patients in the intervention group received IMT prior to surgery. Feasibility was assessed on the basis of the occurrence of adverse effects during testing or training and patient satisfaction. Initial effectiveness on respiratory function was evaluated by maximal inspiratory pressure (MIP) and endurance, the incidence of post-operative pneumonia and length of hospital stay. Eighty-three patients were included, of which 44 received pre-operative IMT. No adverse effects were observed. IMT was well tolerated and appreciated. In the intervention group, the median MIP and endurance improved significantly after IMT by 32% and 41%, respectively (p < 0.001). The incidence of post-operative pneumonia and the length of hospital stay were comparable for the intervention and the conventional care groups (pneumonia, 25% vs. 23% [p = 0.84]; hospitalization, 13.5 vs. 12 days [p = 0.08]). Pre-operative IMT is feasible in patients with oesophageal carcinoma and significantly improves respiratory muscle function. This, however, did not result in a reduction of post-operative pneumonia in patients undergoing oesophagectomy

Published
2013

88. Een inflammatoire pseudotumor in de lever

Author

Kist, Alwine L., Hulsker, Caroline C. C., Verheij, Joanne, Busch, Olivier R. C., Pathology, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, and Surgery

Subjects
eye diseases
Abstract

Inflammatory pseudotumours are rare benign tumours that can present as solid and potentially malignant tumours on diagnostic images. A 59-year-old male presented at the emergency department with continuous pain in his right upper abdomen, attacks of colic and intermittent fever. CT scans of the abdomen revealed a solid lesion in the liver. Histopathological analysis of a biopsy showed an inflammatory pseudotumour. Since the pain persisted and a malignancy could not be excluded with certainty, surgical resection of the tumour was performed. The specimen showed an inflammatory pseudotumour with an increase in IgG4 positive plasma cells as well as a purulent infection around aggregates of Actinomyces. It is important to realise that a pseudotumour caused by an inflammatory reaction can mimic a malignancy

Published
2013

89. Results of the introduction of a minimally invasive esophagectomy program in a tertiary referral center

Author

Blom, Rachel L. G. M., Klinkenbijl, Jean H. G., Hollmann, Markus W., Bergman, Jacques J. G. H. M., Cuesta, Miguel A., Bemelman, Willem A., Busch, Olivier R. C., van Berge Henegouwen, M. I., Surgery, Anesthesiology, and Gastroenterology and Hepatology

Abstract

Background: Esophagectomy is accompanied by a high postoperative complication rate. Minimally invasive esophageal surgery appears to be a promising technique that might be associated with a lower pulmonary morbidity rate. The objective of this study was to describe the implementation of minimally invasive esophageal surgery in a tertiary referral center and to compare the results of our first series of minimally invasive esophagectomies (MIE) to conventional open esophagectomies. Methods: MIE was implemented after several procedures had been proctored by a surgeon with extensive experience with MIE. Preoperative characteristics and the postoperative course of patients who underwent a transthoracic esophagectomy were prospectively registered. Morbidity and overall hospital stay were compared between minimally invasive and open resections performed in the same period. Results: A total of 90 consecutive esophageal cancer patients underwent a transthoracic resection, 41 patients by means of a minimally invasive approach. Preoperative characteristics were comparable for both groups. The duration of surgery was longer in the MIE group (6.0 vs. 5.2 hours, P

Published
2012

91. Centralisatie van hoogcomplexe chirurgie

Author

Gouma, Dirk J., Laméris, Han J. S., Rauws, Eric A. J., Busch, Olivier R. C., Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and Nuclear Medicine, Cancer Center Amsterdam, and Gastroenterology and Hepatology

Abstract

The relationship between hospital volume and outcome of care after pancreatic surgery, particularly mortality, has been described extensively in the past. Today, this relationship is frequently being used by healthcare providers and/or insurance companies to select hospitals for various surgical procedures. This concept, however, has many limitations. The conceptual model concerning the relationship between how hospital facilities are arranged and the different aspects of the process of providing healthcare is discussed in three case histories describing complicated postoperative courses after pancreatic resections. The conclusion is that, besides hospital volume, the manner in which the various facilities in hospitals are arranged as well as the process of care giving, particularly the effectiveness of multidisciplinary meetings, are of crucial importance to the quality of care. Data per illness, with adequate correction for case mix, are of crucial importance for comparing the differences in quality of care between hospitals

Published
2012

93. Reply to Letter

Author

Harlaar, Joris J., primary, Gosselink, Martijn P., additional, Hop, Wim C., additional, Lange, Johan F., additional, Busch, Olivier R. C., additional, and Jeekel, Hans, additional

Published
2015
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94. Leverresectie mogelijk gemaakt door preoperatieve embolisatie van takken van de V. portae en daardoor compensatoire vergroting van de toekomstige restlever

Author

van den Esschert, Jacomina W., de Graaf, Wilmar, van Lienden, Krijn P., Busch, Olivier R. C., van Delden, Otto M., Gouma, Dirk J., Laméris, J. S., van Gulik, Thomas M., Other departments, Radiology and Nuclear Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Surgery, and Amsterdam Cardiovascular Sciences

Published
2009

95. Behandeling van chronische pancreatitis. Recente inzichten

Author

van der Gaag, Niels A., Boermeester, Marja A., Cahen, Djuna L., Busch, Olivier R. C., Rauws, Erik A. J., van Gulik, Thomas M., Bruno, Marco J., Gouma, Dirk J., Other departments, Amsterdam institute for Infection and Immunity, Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, Cancer Center Amsterdam, and Gastroenterology and Hepatology

Published
2009

99. Case report of a smuggler's dinner: carrots and asparagus, or bolitas?

Author

Raben, Adriana M. T. J., Phoa, Saffire S. K. S., Busch, Olivier R. C., Schultz, Marcus J., Radiology and Nuclear Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Surgery, Amsterdam institute for Infection and Immunity, and Intensive Care Medicine

Abstract

BACKGROUND: Body packing is a distinct method of drug smuggling. Surgeons and intensive care specialists will be confronted with body packers when packets do not pass spontaneously and rupture, causing drug toxicity. CASE REPORT: We report of a 32-year-old Liberian male who presented with abdominal complaints and anxiety after having ingested 50 cocaine-containing packets of which 49 had passed the natural route in the previous days. X-ray of his abdomen showed a structure possibly compatible with a packet in or projected over the stomach. We decided to transfer the patient to the operation theatre for surgical removal via gastrotomy. However, no packet was found. During his first day in the intensive care unit he did not regain consciousness. Repeated urine analyses for cocaine were negative. After one day he deteriorated: he needed circulatory support because of hypotension, without signs of sepsis. Repeated surgery revealed no packet. In the end he turned out not to be suffering from cocaine intoxication. CONCLUSIONS: When confronted with a case of body packing in which packets do not pass spontaneously and produce bowel obstruction or in which badly wrapped packets rupture, causing drug toxicity, it is of utmost importance to establish the nature of the packet's content

Published
2005

100. Antecolic Versus Retrocolic Route of the Gastroenteric Anastomosis After Pancreatoduodenectomy

Author

Eshuis, Wietse J., primary, van Eijck, Casper H. J., additional, Gerhards, Michael F., additional, Coene, Peter P., additional, de Hingh, Ignace H. J. T., additional, Karsten, Thom M., additional, Bonsing, Bert A., additional, Gerritsen, Josephus J. G. M., additional, Bosscha, Koop, additional, Spillenaar Bilgen, Ernst J., additional, Haverkamp, Jorien A., additional, Busch, Olivier R. C., additional, van Gulik, Thomas M., additional, Reitsma, Johannes B., additional, and Gouma, Dirk J., additional

Published
2014
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