5,112 results on '"Bulgarelli A."'
Search Results
52. Differential Effect of Positive End-Expiratory Pressure Strategies in Patients With ARDS: A Bayesian Analysis of Clinical Subphenotypes
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Siuba, Matthew T., Bulgarelli, Lucas, Duggal, Abhijit, Cavalcanti, Alexandre B., Zampieri, Fernando G., Rey, Diego Ariel, Lucena, Wellington dos Reis, Maia, Israel S., Paisani, Denise M., Laranjeira, Ligia N., Neto, Ary Serpa, and Deliberato, Rodrigo Octávio
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- 2024
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53. Performance and Failure of Right Ventricle to Pulmonary Artery Conduit in Congenital Heart Disease
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D'Angelo, Emanuela Concetta, Egidy Assenza, Gabriele, Balducci, Anna, Bartolacelli, Ylenia, Bulgarelli, Ambra, Careddu, Lucio, Ciuca, Cristina, Mariucci, Elisabetta, Ragni, Luca, Donti, Andrea, Gargiulo, Gaetano Domenico, and Angeli, Emanuela
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- 2024
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54. Sequential immunotherapy and targeted therapy for metastatic BRAF V600 mutated melanoma: 4-year survival and biomarkers evaluation from the phase II SECOMBIT trial
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Paolo A. Ascierto, Milena Casula, Jenny Bulgarelli, Marina Pisano, Claudia Piccinini, Luisa Piccin, Antonio Cossu, Mario Mandalà, Pier Francesco Ferrucci, Massimo Guidoboni, Piotr Rutkowski, Virginia Ferraresi, Ana Arance, Michele Guida, Evaristo Maiello, Helen Gogas, Erika Richtig, Maria Teresa Fierro, Celeste Lebbe, Hildur Helgadottir, Paola Queirolo, Francesco Spagnolo, Marco Tucci, Michele Del Vecchio, Maria Gonzales Cao, Alessandro Marco Minisini, Sabino De Placido, Miguel F. Sanmamed, Domenico Mallardo, Miriam Paone, Maria Grazia Vitale, Ignacio Melero, Antonio M. Grimaldi, Diana Giannarelli, Reinhard Dummer, Vanna Chiarion Sileni, and Giuseppe Palmieri
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Science - Abstract
Abstract No prospective data were available prior to 2021 to inform selection between combination BRAF and MEK inhibition versus dual blockade of programmed cell death protein-1 (PD-1) and cytotoxic T lymphocyte antigen-4 (CTLA-4) as first-line treatment options for BRAFV600-mutant melanoma. SECOMBIT (NCT02631447) was a randomized, three-arm, noncomparative phase II trial in which patients were randomized to one of two sequences with immunotherapy or targeted therapy first, with a third arm in which an 8-week induction course of targeted therapy followed by a planned switch to immunotherapy was the first treatment. BRAF/MEK inhibitors were encorafenib plus binimetinib and checkpoint inhibitors ipilimumab plus nivolumab. Primary outcome of overall survival was previously reported, demonstrating improved survival with immunotherapy administered until progression and followed by BRAF/MEK inhibition. Here we report 4-year survival outcomes, confirming long-term benefit with first-line immunotherapy. We also describe preliminary results of predefined biomarkers analyses that identify a trend toward improved 4-year overall survival and total progression-free survival in patients with loss-of-function mutations affecting JAK or low baseline levels of serum interferon gamma (IFNy). These long-term survival outcomes confirm immunotherapy as the preferred first-line treatment approach for most patients with BRAFV600-mutant metastatic melanoma, and the biomarker analyses are hypothesis-generating for future investigations of predictors of durable benefit with dual checkpoint blockade and targeted therapy.
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- 2024
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55. Comprehensive genomic profiling on metastatic Melanoma: results from a network screening from 7 Italian Cancer Centres
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Matteo Pallocca, Ivan Molineris, Enrico Berrino, Benedetta Marcozzi, Martina Betti, Lauretta Levati, Stefania D’Atri, Chiara Menin, Gabriele Madonna, Paola Ghiorzo, Jenny Bulgarelli, Virgina Ferraresi, Tiziana Venesio, Monica Rodolfo, Licia Rivoltini, Luisa Lanfrancone, Paolo Antonio Ascierto, Luca Mazzarella, Pier Giuseppe Pelicci, Ruggero De Maria, Gennaro Ciliberto, Enzo Medico, and Giandomenico Russo
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Comprehensive genomic profiling ,Network trial ,Alleanza Contro il Cancro ,Melanoma ,SKCM ,Immuno-checkpoint inhibitors ,Medicine - Abstract
Abstract Background The current therapeutic algorithm for Advanced Stage Melanoma comprises of alternating lines of Targeted and Immuno-therapy, mostly via Immune-Checkpoint blockade. While Comprehensive Genomic Profiling of solid tumours has been approved as a companion diagnostic, still no approved predictive biomarkers are available for Melanoma aside from BRAF mutations and the controversial Tumor Mutational Burden. This study presents the results of a Multi-Centre Observational Clinical Trial of Comprehensive Genomic Profiling on Target and Immuno-therapy treated advanced Melanoma. Methods 82 samples, collected from 7 Italian Cancer Centres of FFPE-archived Metastatic Melanoma and matched blood were sequenced via a custom-made 184-gene amplicon-based NGS panel. Sequencing and bioinformatics analysis was performed at a central hub. Primary analysis was carried out via the Ion Reporter framework. Secondary analysis and Machine Learning modelling comprising of uni and multivariate, COX/Lasso combination, and Random Forest, was implemented via custom R/Python scripting. Results The genomics landscape of the ACC-mela cohort is comparable at the somatic level for Single Nucleotide Variants and INDELs aside a few gene targets. All the clinically relevant targets such as BRAF and NRAS have a comparable distribution thus suggesting the value of larger scale sequencing in melanoma. No comparability is reached at the CNV level due to biotechnological biases and cohort numerosity. Tumour Mutational Burden is slightly higher in median for Complete Responders but fails to achieve statistical significance in Kaplan–Meier survival analysis via several thresholding strategies. Mutations on PDGFRB, NOTCH3 and RET were shown to have a positive effect on Immune-checkpoint treatment Overall and Disease-Free Survival, while variants in NOTCH4 were found to be detrimental for both endpoints. Conclusions The results presented in this study show the value and the challenge of a genomics-driven network trial. The data can be also a valuable resource as a validation cohort for Immunotherapy and Target therapy genomic biomarker research.
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- 2024
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56. Immuno markers in newly diagnosed glioblastoma patients underwent Stupp protocol after neurosurgery: a retrospective series
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Gurrieri, Lorena, Mercatali, Laura, Ibrahim, Toni, Fausti, Valentina, Dall’Agata, Monia, Riva, Nada, Ranallo, Nicoletta, Pasini, Giuseppe, Tazzari, Marcella, Foca, Flavia, Bartolini, Daniela, Riccioni, Luca, Cavatorta, Chiara, Morigi, Federico Paolo, Bulgarelli, Jenny, Cocchi, Claudia, Ghini, Virginia, Tosatto, Luigino, Martinelli, Giovanni, Pession, Andrea, and Ridolfi, Laura
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- 2023
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57. Second Language between marginalization and social inclusion. Qualitative survey on SL training services and on the social inclusion needs of migrants, an intercultural and postcolonial reading
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Aurora Bulgarelli
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sl learning ,interculture ,adult migrants ,empowerment ,inclusion ,Education ,Education (General) ,L7-991 - Abstract
In the migrant’s path to social inclusion, learning the Second Language (SL) is a fundamental step and the educational environments can represent heterogeneous ideological spaces for the emergence of multivocal narratives (Chakrabarty, 2004). SL education can reproduce colonial relations, determining forms of subordinate integration based on the social structural asymmetries and that finds one of the regulatory principles in the category of race (Fanon, 1961). At the same time, SL education can promote an intercultural and problem posing education (Freire, 2018), committed to deconstructing these relationships with Otherness. This contribution deals with some aspects of broader doctoral research, relating to the topic of SL and the inclusiveness, or marginalisation, of educational action. The qualitative investigation was carried out in the city of Rome through 60 semi-structured interviews. What emerged is that the different perception of the SL influences the migrant’s path to social inclusion as learning can respond to social and emancipatory needs, but also to needs linked to the socio-economic dimension and the fulfillment of regulatory requirements, leading to a risk of social exclusion.
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- 2023
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58. Colonisation of the imaginary in social ecosystem. An intersectional analysis of the representation of aesthetic-cultural differences in brand marketing policies
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Fabio Bocci, Martina De Castro, Aurora Bulgarelli, and Umberto Zona
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cultural models ,inclusion ,intersectionality ,brand ,instagram ,Education ,Education (General) ,L7-991 - Abstract
As early as the 1970s, activists such as Assata Shakur addressed the issue of the imposition of white cultural and aesthetic models and the risk of these being uncritically acquired by the new generations of the African American community. Today, the space of social networks seems to allow greater freedom in the representation of the self and in the choice of contents to follow, enabling modes of self-representation and processes of empowerment. However, in the virtual dimension of the Web, the social, class, race, dis/ability and gender asymmetries that characterise onlife seem to be replicated. Assuming an intersectional perspective, the authors of this contribution propose the first results of an exploratory research aimed at investigating the degree of inclusiveness of companies operating on the Net and their effective capacity to offer, within the advertising campaigns, a representation of the multiform identity spectrum. Specifically, the Instagram profiles of well-known brands in the fields of cosmetics, make-up and fashion are analysed as case studies.
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- 2023
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59. Outdoor Play of Children with and without Disabilities. Insights from the COVID-19 Pandemic in Ireland and Italy
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Bulgarelli, Daniela, Bianquin, Nicole, Barron, Carol, and Emmett, Mary-Jane
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Several factors might affect outdoor play (individual and family aspects, neighbourhood environment, policy and socio-cultural factors). The Covid-19 lockdowns became a barrier to outdoor play and had a greater impact on children with disabilities. This study describes the outdoor activities and play and the contextual factors that affected them in 4- to 13-year-old children with and without disabilities. 1,667 parents answered an online questionnaire with both open-ended and close-ended questions during the first lockdown in Ireland and Italy in 2020. Parents perceived their children as being unable to play outside as they could before COVID-19. The built environment impacted children's access to outdoor spaces. A content analysis was run on the parents' responses to open-ended questions describing children's outdoor activities and play, and the contextual factors affecting them. Results showed that the active role of adults in organising routines, spaces and introducing changes, and the existing features of the outdoor built environment were crucial to support outdoor play. Comparing the contextual factors supporting outdoor play and activities of children with and without disabilities, the main difference concerned the type of role played by the adults. Some differences due to age, gender and nationality were also discussed.
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- 2023
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60. Theory of Mind Development in Italian Children with Specific Language Impairment and Autism Spectrum Disorder: Delay, Deficit, or Neither?
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Bulgarelli, Daniela, Testa, Silvia, and Molina, Paola
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Some studies report delayed theory of mind (ToM) development in children with specific language impairment (SLI), while others do not. A ToM delay is acknowledged in children with autism spectrum disorder (ASD), while whether these children also display a deficit is still under debate. In the current study, we drew on a developmental trajectory approach to assess whether children with SLI or ASD displayed delays or deficits in their ToM performance. Forty-three children with SLI (age 4-10 years), 44 children with ASD (age 5-12 years), and 227 typically developing children (age 3-11 years) completed the ToM Storybooks. Children with SLI were not found to display either a delay or a deficit in ToM, while children with ASD were found to display a deficit.
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- 2022
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61. The Compton Spectrometer and Imager Project for MeV Astronomy
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Tomsick, John A., Boggs, Steven E., Zoglauer, Andreas, Wulf, Eric, Mitchell, Lee, Phlips, Bernard, Sleator, Clio, Brandt, Terri, Shih, Albert, Roberts, Jarred, Jean, Pierre, von Ballmoos, Peter, Oliveros, Juan Martinez, Smale, Alan, Kierans, Carolyn, Hartmann, Dieter, Leising, Mark, Ajello, Marco, Burns, Eric, Fryer, Chris, Saint-Hilaire, Pascal, Malzac, Julien, Tavecchio, Fabrizio, Fioretti, Valentina, Bulgarelli, Andrea, Ghirlanda, Giancarlo, Chang, Hsiang-Kuang, Takahashi, Tadayuki, Nakazawa, Kazuhiro, Matsumoto, Shigeki, Melia, Tom, Siegert, Thomas, Lowell, Alexander, Lazar, Hadar, Beechert, Jacqueline, and Gulick, Hannah
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Compton Spectrometer and Imager (COSI) is a 0.2-5 MeV Compton telescope capable of imaging, spectroscopy, and polarimetry of astrophysical sources. Such capabilities are made possible by COSI's germanium cross-strip detectors, which provide high efficiency, high resolution spectroscopy and precise 3D positioning of photon interactions. Science goals for COSI include studies of 0.511 MeV emission from antimatter annihilation in the Galaxy, mapping radioactive elements from nucleosynthesis, determining emission mechanisms and source geometries with polarization, and detecting and localizing multimessenger sources. The instantaneous field of view (FOV) for the germanium detectors is >25% of the sky, and they are surrounded on the sides and bottom by active shields, providing background rejection as well as allowing for detection of gamma-ray bursts or other gamma-ray flares over >50% of the sky. We have completed a Phase A concept study to consider COSI as a Small Explorer (SMEX) satellite mission, and here we discuss the advances COSI-SMEX provides for astrophysics in the MeV bandpass., Comment: 9 pages, 4 figures, 1 table, author affiliations provided on final page. arXiv admin note: substantial text overlap with arXiv:1908.04334
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- 2021
62. STACEX: RPC-based detector for a multi-messenger observatory in the Southern Hemisphere
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Gonzalo, Rodriguez-Fernandez, Ciro, Bigongiari, Andrea, Bulgarelli, Paolo, Camarri, Martina, Cardillo, Giuseppe, Di Sciascio, Valentina, Fioretti, Marco, Romani, Giovanni, Piano, Rinaldo, Santonico, and Marco, Tavani
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Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment - Abstract
Recent findings by the LHAASO experiment are opening a new window, that of the PeV sky, to the observation of the electromagnetic spectrum. Several astronomical objects emitting gamma-rays at energies well above 100 TeV have been observed with the LHAASO-KM2 array of scintillators and muon detectors, clearly demonstrating the feasibility of gamma-ray astronomy up to PeV energies. An all-sky gamma-ray detector in the Southern Hemisphere, operating in the GeV-PeV range, could complement LHAASO observations, monitor the Inner Galaxy and the Galactic Center looking for PeVatrons. As shown by LHAASO, a water-Cherenkov based detector is not well suited to measure the energy spectrum up to the PeV range, nor to reach the advisable 100 GeV threshold. The ARGO-YBJ experiment, operated for many years at 4300 m a.s.l. with an energy threshold of about 300 GeV, demonstrated, on the contrary, the capability of a carpet of Resistive Plate Chambers (RPCs) to fully reconstruct showers starting from the GeV range up to about 10 PeV. In this contribution we propose a hybrid detector made of a layer of RPCs on top of a water Cherenkov facility devoted to the detection of muons for the selection of gamma-induced showers by the muon-poor technique. We present the layout and discuss the expected performance., Comment: Proceeding of 37th International Cosmic Ray Conference (ICRC 2021)
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- 2021
63. LOgging UnifieD for ASTRI Mini Array
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Incardona, Federico, Costa, Alessandro, Munari, Kevin, Bruno, Pietro, Bulgarelli, Andrea, Germani, Stefano, Grillo, Alessandro, Schwarz, Joseph, Sciacca, Eva, Tosti, Gino, Vitello, Fabio, and Tudisco, Giuseppe
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The ASTRI (Astrofisica con Specchi a Tecnologia Replicante Italiana) Mini-Array (MA) project is an international collaboration led by the Italian National Institute for Astrophysics (INAF). ASTRI MA is composed of nine Cherenkov telescopes operating in the energy range 1-100 TeV, and it aims to study very high-energy gamma ray astrophysics and optical intensity interferometry of bright stars. ASTRI MA is currently under construction, and will be installed at the site of the Teide Observatory in Tenerife (Spain). The hardware and software system that is responsible of monitoring and controlling all the operations carried out at the ASTRI MA site is the Supervision Control and Data Acquisition (SCADA). The LOgging UnifieD (LOUD) subsystem is one of the main components of SCADA. It provides the service responsible for collecting, filtering, exposing and storing log events collected by all the array elements (telescopes, LIDAR, devices, etc.). In this paper, we present the LOUD architecture and the software stack explicitly designed for distributed computing environments exploiting Internet of Things technologies (IoT).
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- 2021
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64. The AGILE real-time analysis pipelines in the multi-messenger era
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Parmiggiani, N., Bulgarelli, A., Ursi, A., Fioretti, V., Baroncelli, L., Addis, A., Di Piano, A., Pittori, C., Verrecchia, F., Lucarelli, F., Tavani, M., and Beneventano, D.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
In the multi-messenger era, space and ground-based observatories usually develop real-time analysis (RTA) pipelines to rapidly detect transient events and promptly share information with the scientific community to enable follow-up observations. These pipelines can also react to science alerts shared by other observatories through networks such as the Gamma-Ray Coordinates Network (GCN) and the Astronomer's Telegram (ATels). AGILE is a space mission launched in 2007 to study X-ray and gamma-ray phenomena. This contribution presents the technologies used to develop two types of AGILE pipelines using the RTApipe framework and an overview of the main scientific results. The first type performs automated analyses on new AGILE data to detect transient events and automatically sends AGILE notices to the GCN network. Since May 2019, this pipeline has sent more than 50 automated notices with a few minutes delay since data arrival. The second type of pipeline reacts to multi-messenger external alerts (neutrinos, gravitational waves, GRBs, and other transients) received through the GCN network and performs hundreds of analyses searching for counterparts in all AGILE instruments' data. The AGILE Team uses these pipelines to perform fast follow-up of science alerts reported by other facilities, which resulted in the publishing of several ATels and GCN circulars., Comment: 8 pages, 3 figures, Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021), Berlin, Germany
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- 2021
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65. The Online Observation Quality System for the ASTRI Mini-Array
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Parmiggiani, N., Bulgarelli, A., Baroncelli, L., Addis, A., Fioretti, V., Di Piano, A., Capalbi, M., Catalano, O., Conforti, V., Fiori, M., Gianotti, F., Iovenitti, S., Lucarelli, F., Maccarone, M. C., Mineo, T., Russo, F., Sangiorgi, P., Scuderi, S., Tosti, G., Trifoglio, M., and Zampieri, L.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The ASTRI Mini-Array is an international collaboration led by the Italian National Institute for Astrophysics (INAF), aiming to construct and operate an array of nine Imaging Atmospheric Cherenkov Telescopes (IACTs) to study gamma-ray sources at very high energy (TeV) and to perform stellar intensity interferometry observations. This contribution describes the design and the technologies used by the ASTRI team to implement the Online Observation Quality System (OOQS). The main objective of the OOQS is to perform data quality analyses in real-time during Cherenkov and intensity interferometry observations to provide feedback to both the Central Control System and the Operator. The OOQS performs the analysis of key data quality parameters and can generate alarms to other sub-systems for a fast reaction to solve critical conditions. The results from the data quality analyses are saved into the Quality Archive for further investigations. The Operator can visualise the OOQS results through the Operator Human Machine Interface as soon as they are produced. The main challenge addressed by the OOQS design is to perform online data quality checks on the data streams produced by nine telescopes, acquired by the Array Data Acquisition System and forwarded to the OOQS. In the current OOQS design, the Redis in-memory database manages the data throughput generated by the telescopes, and the Slurm workload scheduler executes in parallel the high number of data quality analyses., Comment: 8 pages, 3 figures, Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021), Berlin, Germany
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- 2021
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66. Detection methods for the Cherenkov Telescope Array at very-short exposure times
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Di Piano, Ambra, Bulgarelli, Andrea, Fioretti, Valentina, Baroncelli, Leonardo, Parmiggiani, Nicolò, Longo, Francesco, Stamerra, Antonio, López-Oramas, Alicia, Stratta, Giulia, and De Cesare, and Giovanni
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Cherenkov Telescope Array (CTA) will be the next generation ground-based observatory for very-high-energy (VHE) gamma-ray astronomy, with the deployment of tens of highly sensitive and fast-reacting Cherenkov telescopes. It will cover a wide energy range (20 GeV - 300 TeV) with unprecedented sensitivity. To maximize the scientific return, the observatory will be provided with an online software system that will perform the first analysis of scientific data in real-time. This study investigates the precision and accuracy of available science tools and analysis techniques for the short-term detection of gamma-ray sources, in terms of sky localization, detection significance and, if significant detection is achieved, a first estimation of the integral photon flux. The scope is to evaluate the feasibility of the algorithms' implementation in the real-time analysis of CTA. In this contribution we present a general overview of the methods and some of the results for the test case of the short-term detection of a gamma-ray burst afterglow, as the VHE counterpart of a gravitational wave event., Comment: Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021), PoS(ICRC2021)69, 8 pages + full author list, 5 figures
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- 2021
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67. The Science Alert Generation system of the Cherenkov Telescope Array Observatory
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Bulgarelli, A., Caroff, S., Addis, A., Aubert, P., Baroncelli, L., De Cesare, G., DiPiano, A., Fioretti, V., Garcia, E., Maurin, G., Parmiggiani, N., Vuillaume, T., Oya, I., and Hoischen, C.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Cherenkov Telescope Array (CTA) Observatory, with dozens of telescopes located in both the Northern and Southern Hemispheres, will be the largest ground-based gamma-ray observatory and will provide broad energy coverage from 20 GeV to 300 TeV. The large effective area and field-of-view, coupled with the fast slewing capability and unprecedented sensitivity, make CTA a crucial instrument for the future of ground-based gamma-ray astronomy. To maximise the scientific return, the array will send alerts on transients and variable phenomena (e.g. gamma-ray burst, active galactic nuclei, gamma-ray binaries, serendipitous sources). Rapid and effective communication to the community requires a reliable and automated system to detect and issue candidate science alerts. This automation will be accomplished by the Science Alert Generation (SAG) pipeline, a key system of the CTA Observatory. SAG is part of the Array Control and Data Acquisition (ACADA) working group. The SAG working group develops the pipelines to perform data reconstruction, data quality monitoring, science monitoring and real-time alert issuing during observations to the Transients Handler functionality of ACADA. SAG is the system that performs the first real-time scientific analysis after the data acquisition. The system performs analysis on multiple time scales (from seconds to hours). \abrb{SAG must issue candidate science alerts within} 20 seconds from the data taking and with sensitivity at least half of the CTA nominal sensitivity. These challenging requirements must be fulfilled by managing trigger rates of tens of kHz from the arrays. Dedicated and highly optimised software and hardware architecture must thus be designed and tested. In this work, we present the general architecture of the ACADA-SAG system., Comment: 8 pages, 2 figures, Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021), Berlin, Germany
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- 2021
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68. Prospects for Galactic transient sources detection with the Cherenkov Telescope Array
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López-Oramas, A., Bulgarelli, A., Chaty, S., Chernyakova, M., Gnatyk, R., Hnatyk, B., Kantzas, D., Markoff, S., McKeague, S., Mereghetti, S., Mestre, E., di Piano, A., Romano, P., Sadeh, I., Sergijenko, O., Sidoli, L., Spolon, A., Wilhelmi, E. de Oña, Piano, G., and Zampieri, L.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Several types of Galactic sources, like magnetars, microquasars, novae or pulsar wind nebulae flares, display transient emission in the X-ray band. Some of these sources have also shown emission at MeV--GeV energies. However, none of these Galactic transients have ever been detected in the very-high-energy (VHE; E$>$100 GeV) regime by any Imaging Air Cherenkov Telescope (IACT). The Galactic Transient task force is a part of the Transient Working group of the Cherenkov Telescope Array (CTA) Consortium. The task force investigates the prospects of detecting the VHE counterpart of such sources, as well as their study following Target of Opportunity (ToO) observations. In this contribution, we will show some of the results of exploring the capabilities of CTA to detect and observe Galactic transients; we assume different array configurations and observing strategies., Comment: 37th International Cosmic Ray Conference (ICRC2021)
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- 2021
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69. Searching for very-high-energy electromagnetic counterparts to gravitational-wave events with the Cherenkov Telescope Array
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Patricelli, Barbara, Carosi, Alessandro, Nava, Lara, Seglar-Arroyo, Monica, Schüssler, Fabian, Stamerra, Antonio, Adelfio, Andrea, Ashkar, Halim, Bulgarelli, Andrea, Di Girolamo, Tristano, Di Piano, Ambra, Gasparetto, Thomas, Green, Jarred, Longo, Francesco, Agudo, Ivan, Berti, Alessio, Bissaldi, Elisabetta, Cella, Giancarlo, Circiello, Antonio, Covino, Stefano, Ghirlanda, Giancarlo, Humensky, Brian, Inoue, Susumu, Lefaucheur, Julien, Filipovic, Miroslav, Razzano, Massimiliano, Ribeiro, Deivid, Sergijenko, Olga, Stratta, Giulia, and Vergani, Susanna
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The detection of electromagnetic (EM) emission following the gravitational wave (GW) event GW170817 opened the era of multi-messenger astronomy with GWs and provided the first direct evidence that at least a fraction of binary neutron star (BNS) mergers are progenitors of short Gamma-Ray Bursts (GRBs). GRBs are also expected to emit very-high energy (VHE, > 100 GeV) photons, as proven by the recent MAGIC and H.E.S.S. observations. One of the challenges for future multi-messenger observations will be the detection of such VHE emission from GRBs in association with GWs. In the next years, the Cherenkov Telescope Array (CTA) will be a key instrument for the EM follow-up of GW events in the VHE range, owing to its unprecedented sensitivity, rapid response, and capability to monitor a large sky area via scan-mode operation. We present the CTA GW follow-up program, with a focus on the searches for short GRBs possibly associated with BNS mergers. We investigate the possible observational strategies and we outline the prospects for the detection of VHE EM counterparts to transient GW events., Comment: Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021); PoS (ICRC2021) 998
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- 2021
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70. The AGILEScience mobile application for the AGILE space mission
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Parmiggiani, N., Bulgarelli, A., Tavani, M., Pittori, C., Baroncelli, L., Malaspina, M., Beneventano, D., Castaldini, L., Di Piano, A., Falco, R., Fioretti, V., Lucarelli, F., Panebianco, G., and Verrecchia, F.
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- 2024
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71. A critical analysis and improvements of empirical models for predicting the performance of Electrical Submersible Pumps under viscous flow
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Monte Verde, William, Kindermann, Ellen, Bulgarelli, Natan Augusto Vieira, Pastre, Luiz Fernando, Foresti, Bernardo, and Bannwart, Antonio Carlos
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- 2024
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72. Re-irradiation for recurrent intracranial meningiomas: Analysis of clinical outcomes and prognostic factors
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Desideri, Isacco, Morelli, Ilaria, Banini, Marco, Greto, Daniela, Visani, Luca, Nozzoli, Filippo, Caini, Saverio, Della Puppa, Alessandro, Livi, Lorenzo, Perini, Zeno, Zivelonghi, Emanuele, Bulgarelli, Giorgia, Pinzi, Valentina, Navarria, Pierina, Clerici, Elena, Scorsetti, Marta, Ascolese, Anna Maria, Osti, Mattia Falchetto, Anselmo, Paola, Amelio, Dante, Minniti, Giuseppe, and Scartoni, Daniele
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- 2024
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73. Author Correction: MIMIC-IV, a freely accessible electronic health record dataset
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Johnson, Alistair E. W., Bulgarelli, Lucas, Shen, Lu, Gayles, Alvin, Shammout, Ayad, Horng, Steven, Pollard, Tom J., Moody, Benjamin, Gow, Brian, Lehman, Li-wei H., Celi, Leo A., and Mark, Roger G.
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- 2023
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74. MIMIC-IV, a freely accessible electronic health record dataset
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Johnson, Alistair E. W., Bulgarelli, Lucas, Shen, Lu, Gayles, Alvin, Shammout, Ayad, Horng, Steven, Pollard, Tom J., Hao, Sicheng, Moody, Benjamin, Gow, Brian, Lehman, Li-wei H., Celi, Leo A., and Mark, Roger G.
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- 2023
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75. Magnetic resonance-guided focused ultrasound unilateral thalamotomy for medically refractory essential tremor: 3-year follow-up data
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Stefano Tamburin, Fabio Paio, Tommaso Bovi, Giorgia Bulgarelli, Michele Longhi, Roberto Foroni, Elisa Mantovani, Paolo Maria Polloniato, Micaela Tagliamonte, Emanuele Zivelonghi, Chiara Zucchella, Carlo Cavedon, Antonio Nicolato, Benedetto Petralia, Francesco Sala, Bruno Bonetti, Michele Tinazzi, Stefania Montemezzi, and Giuseppe Kenneth Ricciardi
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functional neurosurgery ,MRgFUS ,non-invasive ,thalamus ,thalamotomy ,tremor ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
IntroductionMagnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy of the ventralis intermediate (Vim) nucleus is an “incisionless” treatment for medically refractory essential tremor (ET). We present data on 49 consecutive cases of MRgFUS Vim thalamotomy followed-up for 3 years and review the literature on studies with longer follow-up data.MethodsA retrospective chart review of patients who underwent MRgFUS thalamotomy (January 2018–December 2020) at our institution was performed. Clinical Rating Scale for Tremor (CRST) and Quality of Life in Essential Tremor (QUEST) scores were obtained pre-operatively and at each follow-up with an assessment of side effects. Patients had post-operative magnetic resonance imaging within 24 h and at 1 month to figure out lesion location, size, and extent. The results of studies with follow-up ≥3 years were summarized through a literature review.ResultsThe CRST total (baseline: 58.6 ± 17.1, 3-year: 40.8 ± 18.0) and subscale scores (A + B, baseline: 23.5 ± 6.3, 3-year: 12.8 ± 7.9; C, baseline: 12.7 ± 4.3, 3-year: 5.8 ± 3.9) and the QUEST score (baseline: 38.0 ± 14.8, 3-year: 18.7 ± 13.3) showed significant improvement that was stable during the 3-year follow-up. Three patients reported tremor recurrence and two were satisfactorily retreated. Side effects were reported by 44% of patients (severe: 4%, mild and transient: 40%). The improvement in tremor and quality of life in our cohort was consistent with the literature.ConclusionWe confirmed the effectiveness and safety of MRgFUS Vim thalamotomy in medically refractory ET up to 3 years.
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- 2024
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76. New-onset organ dysfunction as a screening tool for the identification of sepsis and outcome prediction in dogs with systemic inflammation
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Elena Ciuffoli, Roberta Troìa, Cecilia Bulgarelli, Alessandra Pontiero, Francesca Buzzurra, and Massimo Giunti
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canine ,base excess ,stupor ,coma ,acute kidney injury ,hemostatic dysfunction ,Veterinary medicine ,SF600-1100 - Abstract
IntroductionSepsis in people is defined as a life-threatening organ dysfunction (OD) caused by a dysregulated host response to infection. In veterinary medicine, sepsis is still defined by the presence of systemic inflammation plus the evidence of infection. Based on recent veterinary studies, multiorgan dysfunction syndrome (MODS) has been associated with a worse outcome in sepsis. Thus, the screening for OD is warranted to identify the most critically ill patients. The aim of this study was to investigate the diagnostic value of new-onset OD for the prediction of sepsis and outcome in a population of critically ill dogs with systemic inflammation.Materials and methodsDogs admitted to the Emergency Room and/or the Intensive Care Unit with systemic inflammation, defined by a serum C-reactive protein concentration > 1.6 mg/dL, were retrospectively included. Enrolled dogs were categorized according to the presence of sepsis or non-infectious systemic inflammation. The presence of newly diagnosed OD was assessed based on criteria adapted from human literature and previously reported canine criteria.Results275 dogs were included: 128 had sepsis and 147 had non-infectious systemic inflammation. The frequency of new-onset OD was not different between these groups. Only the presence of fluid-refractory hypotension was significantly associated with a diagnosis of sepsis (OR 10.51, 3.08–35.94; p
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- 2024
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77. Multi-messenger and transient astrophysics with the Cherenkov Telescope Array
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Bošnjak, Ž., Brown, A. M., Carosi, A., Chernyakova, M., Cristofari, P., Longo, F., López-Oramas, A., Santander, M., Satalecka, K., Schüssler, F., Sergijenko, O., Stamerra, A., Agudo, I., Batista, R. Alves, Amato, E., Anguner, E. O., Antonelli, L. A., Backes, M., Balazs, Csaba, Baroncelli, L., Tjus, J. Becker, Bigongiari, C., Bissaldi, E., Boisson, C., Bolmont, J., Böttcher, M., Bordas, P., Braiding, C., Bregeon, J., Bucciantini, N., Bulgarelli, A., Burton, M., Cangemi, F., Caraveo, P., Cardillo, M., Caroff, S., Casanova, S., Chaty, S., Coelho, J. G., Cotter, G., D'Aì, A., D'Ammando, F., Pino, E. M. de Gouveia Dal, della Volpe, D., de Martino, D., Di Girolamo, T., Di Piano, A., Djannati-Ataï, A., Dwarkadas, V., Wilhelmi, E. de Ona, Anjos, R. C. Dos, Emery, G., Fedorova, E., Fegan, S., Fiasson, A., Fioretti, V., Filipovic, M. D., Gaggero, D., Galanti, G., Gasparrini, D., Ghirlanda, G., Goldoni, P., Granot, J., Green, J. G., Heller, M., Hnatyk, B., Hnatyk, R., Horan, D., Hovatta, T., Inoue, S., Jamrozy, M., Kantzas, D., Khélifi, B., Komin, N., Lamastra, A., La Palombara, N., Lenain, J. P., Lindfors, E., Liodakis, I., Lombardi, S., Lucarelli, F., Luque-Escamilla, P. L., Majumdar, P., Marcowith, A., Markoff, S., Marti, J., Martinez, M., Mazin, D., McKeague, S., Mereghetti, S., Mestre, E., Montaruli, T., Morlino, G., Morselli, A., Mundell, C., Murach, T., Nava, L., Nayerhoda, A., Nicastro, L., Niemiec, J., Nikolajuk, M., Olmi, B., Ong, R., Orienti, M., Osborne, J. P., Paredes, Josep M., Pareschi, G., Parmiggiani, N., Patricelli, B., Pe'er, A., Piano, G., Pühlhofer, G., Punch, M., Reimer, O., Ribó, M., Rodriguez, G., Rodriguez, J., Romano, P., Romeo, G., Roncadelli, M., Rowell, G., Rudak, B., Sadeh, I., Greus, F. Salesa, Saturni, F. G., Sawangwit, U., Seglar-Arroyo, M., Shellard, R. C., Sol, H., Starling, R., Stolarczyk, T., Tagliaferri, G., Tavecchio, F., Tibaldo, L., Testa, V., Vercellone, S., Viana, A., Vink, J., Vitale, V., Vergani, S. D., Vorobiov, S., Wierzcholska, A., Yang, L., Zavrtanik, D., and Zhdanov, V.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The discovery of gravitational waves, high-energy neutrinos or the very-high-energy counterpart of gamma-ray bursts has revolutionized the high-energy and transient astrophysics community. The development of new instruments and analysis techniques will allow the discovery and/or follow-up of new transient sources. We describe the prospects for the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory, for multi-messenger and transient astrophysics in the decade ahead. CTA will explore the most extreme environments via very-high-energy observations of compact objects, stellar collapse events, mergers and cosmic-ray accelerators., Comment: Submitted to ASTRONET roadmap on behalf of the CTA consortium
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- 2021
78. rta-dq-lib: a software library to perform online data quality analysis of scientific data
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Baroncelli, Leonardo, Bulgarelli, Andrea, Parmiggiani, Nicolo, Fioretti, Valentina, Addis, Antonio, De Cesare, Giovanni, Di Piano, Ambra, Conforti, Vito, Gianotti, Fulvio, Russo, Federico, Maurin, Gilles, Vuillaume, Thomas, Aubert, Pierre, Garcia, Emilio, and Zoccoli, Antonio
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Cherenkov Telescope Array (CTA) is an initiative that is currently building the largest gamma-ray ground Observatory that ever existed. A Science Alert Generation (SAG) system, part of the Array Control and Data Acquisition (ACADA) system of the CTA Observatory, analyses online the telescope data - arriving at an event rate of tens of kHz - to detect transient gamma-ray events. The SAG system also performs an online data quality analysis to assess the instruments' health during the data acquisition: this analysis is crucial to confirm good detections. A Python and a C++ software library to perform the online data quality analysis of CTA data, called rta-dq-lib, has been proposed for CTA. The Python version is dedicated to the rapid prototyping of data quality use cases. The C++ version is optimized for maximum performance. The library allows the user to define, through XML configuration files, the format of the input data and, for each data field, which quality checks must be performed and which types of aggregations and transformations must be applied. It internally translates the XML configuration into a direct acyclic computational graph that encodes the dependencies of the computational tasks to be performed. This model allows the library to easily take advantage of parallelization at the thread level and the overall flexibility allow us to develop generic data quality analysis pipelines that could also be reused in other applications.
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- 2021
79. RTApipe, a framework to develop astronomical pipelines for the real-time analysis of scientific data
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Parmiggiani, N., Bulgarelli, A., Beneventano, D., Fioretti, V., Baroncelli, L., Addis, A., and Tavani, M.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
In the multi-messenger era, astronomical projects share information about transients phenomena issuing science alerts to the Scientific Community through different communications networks. This coordination is mandatory to understand the nature of these physical phenomena. For this reason, astrophysical projects rely on real-time analysis software pipelines to identify as soon as possible transients (e.g. GRBs), and to speed up external alerts' reaction time. These pipelines can share and receive the science alerts through the Gamma-ray Coordinates Network. This work presents a framework designed to simplify the development of real-time scientific analysis pipelines. The framework provides the architecture and the required automatisms to develop a real-time analysis pipeline, allowing the researchers to focus more on the scientific aspects. The framework has been successfully used to develop real-time pipelines for the scientific analysis of the AGILE space mission data. It is planned to reuse this framework for the Super-GRAWITA and AFISS projects. A possible future use for the Cherenkov Telescope Array (CTA) project is under evaluation., Comment: proceedings of the ADASS XXX (2020) conference, to appear in ASP Conference Series
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- 2021
80. Agilepy: A Python framework for scientific analysis of AGILE data
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Bulgarelli, A., Baroncelli, L., Addis, A., Parmiggiani, N., Aboudan, A., Di Piano, A., Fioretti, V., Tavani, M., Pittori, C., Lucarelli, F., and Verrecchia, F.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Italian AGILE space mission, with its Gamma-Ray Imaging Detector (GRID) instrument sensitive in the 30 MeV-50 GeV gamma-ray energy band, has been operating since 2007. Agilepy is an open-source Python package to analyse AGILE/GRID data. The package is built on top of the command-line version of the AGILE Science Tools, developed by the AGILE Team, publicly available and released by ASI/SSDC. The primary purpose of the package is to provide an easy to use high-level interface to analyse AGILE/GRID data by simplifying the configuration of the tasks and ensuring straightforward access to the data. The current features are the generation and display of sky maps and light curves, the access to gamma-ray sources catalogues, the analysis to perform spectral model and position fitting, the wavelet analysis. Agilepy also includes an interface tool providing the time evolution of the AGILE off-axis viewing angle for a chosen sky region. The Flare Advocate team also uses the tool to analyse the data during the daily monitoring of the gamma-ray sky. Agilepy (and its dependencies) can be easily installed using Anaconda., Comment: 4 pages, 1 figure
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- 2021
81. A Deep Learning Method for AGILE-GRID GRB Detection
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Parmiggiani, N., Bulgarelli, A., Fioretti, V., Di Piano, A., Giuliani, A., Longo, F., Verrecchia, F., Tavani, M., Beneventano, D., and Macaluso, A.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The follow-up of external science alerts received from Gamma-Ray Bursts (GRB) and Gravitational Waves (GW) detectors is one of the AGILE Team's current major activities. The AGILE team developed an automated real-time analysis pipeline to analyse AGILE Gamma-Ray Imaging Detector (GRID) data to detect possible counterparts in the energy range 0.1-10 GeV. This work presents a new approach for detecting GRBs using a Convolutional Neural Network (CNN) to classify the AGILE-GRID intensity maps improving the GRBs detection capability over the Li&Ma method, currently used by the AGILE team. The CNN is trained with large simulated datasets of intensity maps. The AGILE complex observing pattern due to the so-called 'spinning mode' is studied to prepare datasets to test and evaluate the CNN. A GRB emission model is defined from the Second Fermi-LAT GRB catalogue and convoluted with the AGILE observing pattern. Different p-value distributions are calculated evaluating with the CNN millions of background-only maps simulated varying the background level. The CNN is then used on real data to analyse the AGILE-GRID data archive, searching for GRB detections using the trigger time and position taken from the Swift-BAT, Fermi-GBM, and Fermi-LAT GRB catalogues. From these catalogues, the CNN detects 21 GRBs with a significance $\geq 3 \sigma$, while the Li&Ma method detects only two GRBs. The results shown in this work demonstrate that the CNN is more effective in detecting GRBs than the Li&Ma method in this context and can be implemented into the AGILE-GRID real-time analysis pipeline., Comment: 15 pages, 14 figures, 2 tables, accepted by ApJ
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- 2021
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82. AGILE Observations of Fast Radio Bursts
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Verrecchia, F., Casentini, C., Tavani, M., Ursi, A., Mereghetti, S., Pilia, M., Cardillo, M., Addis, A., Barbiellini, G., Baroncelli, L., Bulgarelli, A., Cattaneo, P. W., Chen, A., Costa, E., Del Monte, E., Di Piano, A., Ferrari, A., Fioretti, V., Longo, F., Lucarelli, F., Parmiggiani, N., Piano, G., Pittori, C., Rappoldi, A., and Vercellone, S.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report on a systematic search for hard X-ray and gamma-ray emission in coincidence with fast radio bursts (FRBs) observed by the AGILE satellite. We used 13 years of AGILE archival data searching for time coincidences between exposed FRBs and events detectable by the MCAL (0.4-100 MeV) and GRID (50 MeV-30 GeV) detectors at timescales ranging from milliseconds to days/weeks. The current AGILE sky coverage allowed us to extend the search for high-energy emission preceding and following the FRB occurrence. We considered all FRBs sources currently included in catalogues, and identified a sub-sample (15 events) for which a good AGILE exposure either with MCAL or GRID was obtained. In this paper we focus on non-repeating FRBs, compared to a few nearby repeating sources. We did not detect significant MeV or GeV emission from any event. Our hard X-ray upper limits (ULs) in the MeV energy range were obtained for timescales from sub-millisecond to seconds, and in the GeV range from minutes to weeks around event times. We focus on a sub-set of 5 non-repeating and 2 repeating FRB sources whose distances are most likely smaller than that of 180916.J0158+65 (150 Mpc). For these sources, our MeV ULs translate into ULs on the isotropically-emitted energy of about 3x10^46 erg, comparable to that observed in the 2004 giant flare from the Galactic magnetar SGR 1806-20. On average, these nearby FRBs emit radio pulses of energies significantly larger than the recently detected SGR 1935+2154 and are not yet associated with intense MeV flaring., Comment: ApJ, 915, 102
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- 2021
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83. Intersurgeon variations in postoperative length of stay after video-assisted thoracoscopic surgery lobectomy
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Zini, Jonathan, Dayan, Gabriel, Têtu, Maxime, Kfouri, Toni, Maqueda, Luciano Bulgarelli, Abdulnour, Elias, Ferraro, Pasquale, Ghosn, Pierre, Lafontaine, Edwin, Martin, Jocelyne, Nasir, Basil, and Liberman, Moishe
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- 2024
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84. Gamma-ray Astrophysics in the MeV Range: the ASTROGAM Concept and Beyond
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De Angelis, Alessandro, Tatischeff, Vincent, Argan, Andrea, Brandt, Soren, Bulgarelli, Andrea, Bykov, Andrei, Costantini, Elisa, da Silva, Rui Curado, Grenier, Isabelle A., Hanlon, Lorraine, Hartmann, Dieter, Hernanz, Margarida, Kanbach, Gottfried, Kuvvetli, Irfan, Laurent, Philippe, Mazziotta, Mario N., McEnery, Julie, Morselli, Aldo, Nakazawa, Kazuhiro, Oberlack, Uwe, Pearce, Mark, Rico, Javier, Tavani, Marco, von Ballmoos, Peter, Walter, Roland, Wu, Xin, Zane, Silvia, Zdziarski, Andrzej, and Zoglauer, Andreas
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The energy range between about 100 keV and 1 GeV is of interest for a vast class of astrophysical topics. In particular, (1) it is the missing ingredient for understanding extreme processes in the multi-messenger era; (2) it allows localizing cosmic-ray interactions with background material and radiation in the Universe, and spotting the reprocessing of these particles; (3) last but not least, gamma-ray emission lines trace the formation of elements in the Galaxy and beyond. In addition, studying the still largely unexplored MeV domain of astronomy would provide for a rich observatory science, including the study of compact objects, solar- and Earth-science, as well as fundamental physics. The technological development of silicon microstrip detectors makes it possible now to detect MeV photons in space with high efficiency and low background. During the last decade, a concept of detector ("ASTROGAM") has been proposed to fulfil these goals, based on a silicon hodoscope, a 3D position-sensitive calorimeter, and an anticoincidence detector. In this paper we stress the importance of a medium size (M-class) space mission, dubbed "ASTROMEV", to fulfil these objectives., Comment: White Paper for the Voyage 2050 Program by ESA. Accepted for publication in "Experimental Astronomy". arXiv admin note: text overlap with arXiv:1711.01265
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- 2021
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85. Quantum Convolutional Neural Networks for the detection of Gamma-Ray Bursts in the AGILE space mission data.
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Alessandro Rizzo, Nicolò Parmiggiani, Andrea Bulgarelli, Antonio Macaluso, Valentina Fioretti, L. Castaldini, Ambra Di Piano, Gabriele Panebianco, Carlotta Pittori, Marco Tavani, C. Sartori, C. Burigana, V. Cardone, F. Farsian, M. Meneghetti, G. Murante, R. Scaramella, Francesco Schillirò, V. Testa, and T. Trombetti
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- 2024
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86. Left S8 + S9 Bisegmentectomy
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Maqueda, Luciano Bulgarelli, García-Pérez, Alejandro, Gonzalez-Rivas, Diego, Jiang, Lei, Galvez, Carlos, editor, Bolufer, Sergio, editor, Figueroa, Santiago, editor, and Obeso, Andrés, editor
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- 2023
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87. Dendritic cell vaccines as cancer treatment: focus on 13 years of manufacturing and quality control experience in advanced therapy medicinal products
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Granato, Anna Maria, Pancisi, Elena, Piccinini, Claudia, Stefanelli, Monica, Pignatta, Sara, Soldati, Valentina, Carloni, Silvia, Fanini, Francesca, Arienti, Chiara, Bulgarelli, Jenny, Tazzari, Marcella, Scarpi, Emanuela, Passardi, Alessandro, Tauceri, Francesca, La Barba, Giuliano, Maimone, Giuseppe, Baravelli, Stefano, de Rosa, Francesco, Ridolfi, Laura, and Petrini, Massimiliano
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- 2024
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88. Influence of plant proteins blend or polydextrose on freeze-dried açaí (Euterpe oleracea) sorption isotherms and thermal properties
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Matuda, Tatiana G., Bulgarelli, Mariana C., Ribeiro, Eliana P., and Tadini, Carmen C.
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- 2024
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89. The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase
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Barret, Didier, Albouys, Vincent, Herder, Jan-Willem den, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Svoboda, Jiri, Wilms, Joern, Yamasaki, Noriko, Audard, Marc, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Dauser, Thomas, Decourchelle, Anne, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Hartog, Roland den, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Korpela, Seppo, Macculi, Claudio, Mendez, Mariano, Mitsuda, Kazuhisa, Molendi, Silvano, Pajot, François, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Skup, Konrad, Soucek, Jan, Thibert, Tanguy, Vink, Jacco, Webb, Natalie, Chaoul, Laurence, Raulin, Desi, Simionescu, Aurora, Torrejon, Jose Miguel, Acero, Fabio, Branduardi-Raymont, Graziella, Ettori, Stefano, Finoguenov, Alexis, Grosso, Nicolas, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Nicastro, Fabrizio, Sciortino, Salvatore, Yamaguchi, Hiroya, Beaumont, Sophie, Cucchetti, Edoardo, D’Andrea, Matteo, Eckart, Megan, Ferrando, Philippe, Kammoun, Elias, Lotti, Simone, Mesnager, Jean-Michel, Natalucci, Lorenzo, Peille, Philippe, de Plaa, Jelle, Ardellier, Florence, Argan, Andrea, Bellouard, Elise, Carron, Jérôme, Cavazzuti, Elisabetta, Fiorini, Mauro, Khosropanah, Pourya, Martin, Sylvain, Perry, James, Pinsard, Frederic, Pradines, Alice, Rigano, Manuela, Roelfsema, Peter, Schwander, Denis, Torrioli, Guido, Ullom, Joel, Vera, Isabel, Villegas, Eduardo Medinaceli, Zuchniak, Monika, Brachet, Frank, Cicero, Ugo Lo, Doriese, William, Durkin, Malcom, Fioretti, Valentina, Geoffray, Hervé, Jacques, Lionel, Kirsch, Christian, Smith, Stephen, Adams, Joseph, Gloaguen, Emilie, Hoogeveen, Ruud, van der Hulst, Paul, Kiviranta, Mikko, van der Kuur, Jan, Ledot, Aurélien, van Leeuwen, Bert-Joost, van Loon, Dennis, Lyautey, Bertrand, Parot, Yann, Sakai, Kazuhiro, van Weers, Henk, Abdoelkariem, Shariefa, Adam, Thomas, Adami, Christophe, Aicardi, Corinne, Akamatsu, Hiroki, Alonso, Pablo Eleazar Merino, Amato, Roberta, André, Jérôme, Angelinelli, Matteo, Anon-Cancela, Manuel, Anvar, Shebli, Atienza, Ricardo, Attard, Anthony, Auricchio, Natalia, Balado, Ana, Bancel, Florian, Barusso, Lorenzo Ferrari, Bascuñan, Arturo, Bernard, Vivian, Berrocal, Alicia, Blin, Sylvie, Bonino, Donata, Bonnet, François, Bonny, Patrick, Boorman, Peter, Boreux, Charles, Bounab, Ayoub, Boutelier, Martin, Boyce, Kevin, Brienza, Daniele, Bruijn, Marcel, Bulgarelli, Andrea, Calarco, Simona, Callanan, Paul, Campello, Alberto Prada, Camus, Thierry, Canourgues, Florent, Capobianco, Vito, Cardiel, Nicolas, Castellani, Florent, Cheatom, Oscar, Chervenak, James, Chiarello, Fabio, Clerc, Laurent, Clerc, Nicolas, Cobo, Beatriz, Coeur-Joly, Odile, Coleiro, Alexis, Colonges, Stéphane, Corcione, Leonardo, Coriat, Mickael, Coynel, Alexandre, Cuttaia, Francesco, D’Ai, Antonino, D’anca, Fabio, Dadina, Mauro, Daniel, Christophe, Dauner, Lea, DeNigris, Natalie, Dercksen, Johannes, DiPirro, Michael, Doumayrou, Eric, Dubbeldam, Luc, Dupieux, Michel, Dupourqué, Simon, Durand, Jean Louis, Eckert, Dominique, Eiriz, Valvanera, Ercolani, Eric, Etcheverry, Christophe, Finkbeiner, Fred, Fiocchi, Mariateresa, Fossecave, Hervé, Franssen, Philippe, Frericks, Martin, Gabici, Stefano, Gant, Florent, Gao, Jian-Rong, Gastaldello, Fabio, Genolet, Ludovic, Ghizzardi, Simona, Gil, Ma Angeles Alcacera, Giovannini, Elisa, Godet, Olivier, Gomez-Elvira, Javier, Gonzalez, Raoul, Gonzalez, Manuel, Gottardi, Luciano, Granat, Dolorès, Gros, Michel, Guignard, Nicolas, Hieltjes, Paul, Hurtado, Adolfo Jesús, Irwin, Kent, Jacquey, Christian, Janiuk, Agnieszka, Jaubert, Jean, Jiménez, Maria, Jolly, Antoine, Jourdan, Thierry, Julien, Sabine, Kedziora, Bartosz, Korb, Andrew, Kreykenbohm, Ingo, König, Ole, Langer, Mathieu, Laudet, Philippe, Laurent, Philippe, Laurenza, Monica, Lesrel, Jean, Ligori, Sebastiano, Lorenz, Maximilian, Luminari, Alfredo, Maffei, Bruno, Maisonnave, Océane, Marelli, Lorenzo, Massonet, Didier, Maussang, Irwin, Melchor, Alejandro Gonzalo, Le Mer, Isabelle, Millan, Francisco Javier San, Millerioux, Jean-Pierre, Mineo, Teresa, Minervini, Gabriele, Molin, Alexeï, Monestes, David, Montinaro, Nicola, Mot, Baptiste, Murat, David, Nagayoshi, Kenichiro, Nazé, Yaël, Noguès, Loïc, Pailot, Damien, Panessa, Francesca, Parodi, Luigi, Petit, Pascal, Piconcelli, Enrico, Pinto, Ciro, Plaza, Jose Miguel Encinas, Plaza, Borja, Poyatos, David, Prouvé, Thomas, Ptak, Andy, Puccetti, Simonetta, Puccio, Elena, Ramon, Pascale, Reina, Manuel, Rioland, Guillaume, Rodriguez, Louis, Roig, Anton, Rollet, Bertrand, Roncarelli, Mauro, Roudil, Gilles, Rudnicki, Tomasz, Sanisidro, Julien, Sciortino, Luisa, Silva, Vitor, Sordet, Michael, Soto-Aguilar, Javier, Spizzi, Pierre, Surace, Christian, Sánchez, Miguel Fernández, Taralli, Emanuele, Terrasa, Guilhem, Terrier, Régis, Todaro, Michela, Ubertini, Pietro, Uslenghi, Michela, de Vaate, Jan Geralt Bij, Vaccaro, Davide, Varisco, Salvatore, Varnière, Peggy, Vibert, Laurent, Vidriales, María, Villa, Fabrizio, Vodopivec, Boris Martin, Volpe, Angela, de Vries, Cor, Wakeham, Nicholas, Walmsley, Gavin, Wise, Michael, de Wit, Martin, and Woźniak, Grzegorz
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- 2023
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90. Seguimiento de las trayectorias vocacionales de las personas graduadas durante 2016-2021 de la Universidad Veritas desde la teoría de construcción de carrera y diseño de vida
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Raquel Bulgarelli Bolaños
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orientación profesional ,enseñanza superior ,graduado ,empleo ,profesión ,Education - Abstract
El presente artículo es resultado del seguimiento de las trayectorias vocacionales de las personas graduadas durante el 2016-2021 de la Universidad Veritas, el objetivo general fue describir la trayectoria vocacional de esta población, desde la teoría de construcción de carrera y diseño de vida. La metodología fue desde un enfoque cuantitativo y un diseño transversal de tipo descriptivo, la muestra fue probabilística estratificada por asignación proporcional (n=480) y se utilizó como instrumento un formulario digital. Los resultados indican que, de la muestra, la mayoría se encontraba en condición de rezago al momento de la graduación, la media del rendimiento académico es 87. Más de la mitad no trabajó mientras estudió, alrededor de la mitad continuó estudiando luego de su graduación y la mayoría desean vincularse a la universidad; además, la tasa de ocupación es alta. De las personas ocupadas, la mayoría trabaja para el sector privado, no posee puestos de jefatura, tiene un solo empleo y percibe estabilidad, satisfacción, relación del trabajo con la carrera y aporte de la carrera para conseguir empleo. Se concluye que la trayectoria vocacional se caracteriza por rezago académico, pocos espacios de práctica profesional durante la formación, alto rendimiento académico, deseo de vinculación con la universidad, índices positivos de satisfacción laboral, estabilidad laboral, relación con la carrera e ingresos; pero permeada por un porcentaje de desempleo potenciado por la crisis económica producto de la pandemia. Por lo cual, se recomienda reformar las mallas curriculares, continuar potenciando el proyecto de prácticas profesionales y formalizar el servicio de Orientación Profesional.
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- 2023
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91. IDENTIFICATION AND CHARACTERIZATION OF THE FOYER OF THE NATIONAL THEATER OF COSTA RICA AS PART OF THE METHODOLOGICAL STRATEGY FOR THE THREE-DIMENSIONAL MODELING OF THE FUTURE DIGITAL TWIN
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I. Hernández-Salazar and J. P. Bulgarelli-Bolaños
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
This paper summarizes the first results of the third specific objective of the research project: Digital Twin (DT) as a management tool for the programmed conservation plan (PCP), case study: Foyer and Smokers of the National Theater of Costa Rica (TNCR, by its Spanish acronym), developed with the support of the Vice Rectory of Research and Extension of the Technological Institute of Costa Rica. This objective aims to integrate graphic, non-graphic and linked information from the diagnostic stages of the PCP, through three-dimensional modeling, for the definition of conservation actions and future visualization of the DT. However, prior to modeling it was necessary to understand the composition of the structural system of the first body of the TNCR.The project has the information of the building systematized in documents and plans, both original and from subsequent studies and interventions, as well as a three-dimensional model made in 2021. However, there is no "as built" information after the construction or the interventions that have been carried out; in addition, the structural information of foundations, mezzanines and roofs is not integrated with the ornamental and pictorial information; that is, prior to this research there was no precise documentation of the structural elements that make up the study area and that support the heritage with artistic value of the building. Therefore, this paper presents the work carried out between June 2022 and March 2023 to identify and characterize the components of the Foyer and Smokers of the TNCR, using non-invasive techniques.
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- 2023
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92. Entanglement entropy from non-equilibrium Monte Carlo simulations
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Andrea Bulgarelli and Marco Panero
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Algorithms and Theoretical Developments ,Lattice Quantum Field Theory ,Other Lattice Field Theories ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract We study the entanglement entropy in lattice field theory using a simulation algorithm based on Jarzynski’s theorem. We focus on the entropic c-function for the Ising model in two and in three dimensions: after validating our algorithm against known analytical results from conformal field theory in two dimensions, we present novel results for the three-dimensional case. We show that our algorithm, which is highly parallelized on graphics processing units, allows one to precisely determine the subleading corrections to the area law, which have been investigated in many recent works. Possible generalizations of this study to other strongly coupled theories are discussed.
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- 2023
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93. NEUROPATIAS SECUNDÁRIAS
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T.S.R., BRAGA, primary, L.L., BULGARELLI, additional, J.C., VIRGILI, additional, T.T.M.B., GERBER, additional, R.C., SILVA, additional, and V.T.C., CRELIER, additional
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- 2023
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94. Perfil informacional de cirurgiões-dentistas do serviço público sobre a segurança do paciente na assistência odontológica
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Luiza Guilhermina Oliveira Lopes, Giovana Boff, Eloá Rossoni, Luciane Maria Pilotto, and Alexandre Fávero Bulgarelli
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segurança do paciente ,saúde bucal ,sistema único de saúde ,Dentistry ,RK1-715 - Abstract
Objetivo: Analisar as percepções de cirurgiões-dentistas do serviço público sobre aspectos informacionais a respeito da segurança do paciente no cuidado odontológico. Materiais e métodos: Pesquisa descritiva em que um desfecho composto foi construído para apresentar as percepções dos sujeitos de pesquisa sobre o tema. O desfecho propõe a percepção positiva de três aspectos informacionais relacionados à segurança do paciente: conhecimento acerca do sistema de notificações, conhecimento sobre o Programa Nacional de Segurança do Paciente (PNSP) e informações sobre segurança disponíveis no local de trabalho. A coleta de dados aconteceu online, por meio de um questionário autoaplicável, com cirurgiões-dentistas trabalhadores do serviço público de saúde de Porto Alegre/RS. Resultados: Participaram deste estudo 47 cirurgiões(ãs)-dentistas, sendo 74,4% mulheres, 91,4% autodeclarados da raça/cor branca, 65,9% possuíam 31 anos ou mais de idade, 74,5% estavam formados há mais de cinco anos e 59,6% trabalhavam no Sistema Único de Saúde há mais de cinco anos. A prevalência do desfecho composto foi de 12,8%. Observou-se que as prevalências foram de 34% para o conhecimento sobre o Sistema de Notificação e, 34% para o conhecimento sobre o Programa Nacional de Segurança do Paciente e 38,3% para a presença de informações disponíveis no local de trabalho. Discussão: Os resultados apontam a necessidade de trabalhar questões informacionais com estes profissionais de maneira que no dia a dia estressante de trabalho a segurança do paciente seja algo naturalmente presente durante o cuidado odontológico nos espaços de trabalho. Conclusão: Conclui-se que os relatos de incidentes odontológicos foram poucos e o contexto informacional sobre o tema necessita ser trabalhado para que a segurança do paciente seja sempre foco de atenção na prática odontológica.
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- 2024
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95. Case report: First isolation of Yersinia pseudotuberculosis from the blood of a cat
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Raffaele Scarpellini, Massimo Giunti, Cecilia Bulgarelli, Elisabetta Mondo, Erika Esposito, Giammarco Assirelli, and Silvia Piva
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Yersinia pseudotuberculosis ,bloodstream infection ,feline ,bacterial ,blood ,yersiniosis ,Veterinary medicine ,SF600-1100 - Abstract
A 14-year-old female domestic short-haired cat with a diagnosed diabetes mellitus and acromegaly was presented for lethargy and dysorexia. On clinical presentation, the patient showed hyperglycemia, hyperthermia, dull mentation, and dehydration. With the suspicion of an inflammatory or infectious complication of diabetes, she was hospitalized with constant rate infusion of insulin, and empirical ampicillin sulbactam was started. Blood culture revealed positivity for Yersinia pseudotuberculosis and the septic picture was confirmed by blood analysis, with leukocytosis, neutrophilia, and an increased serum amyloid A concentration. The isolated Y. pseudotuberculosis strain showed susceptibility to every antimicrobial tested. During the second day of hospitalization, the onset of hypoglycemia and hypotension was treated with norepinephrine and glucose in fluid therapy. The cat recovered well and was discharged with insulin and amoxicillin-clavulanate. This is the first case of septicemia associated with Y. pseudotuberculosis in a cat, suspected of developing the infection after contact with natural reservoirs such as rodents or birds. This route of transmission should be highlighted especially in relation to the zoonotic potential of the bacteria.
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- 2024
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96. Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation
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Consortium, The Cherenkov Telescope Array, Abdalla, H., Abe, H., Acero, F., Acharyya, A., Adam, R., Agudo, I., Aguirre-Santaella, A., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., B, R. Alves, Amati, L., Amato, E., Ambrosi, G., Angüner, E. O., Araudo, A., Armstrong, T., Arqueros, F., Arrabito, L., Asano, K., Ascasíbar, Y., Ashley, M., Backes, M., Balazs, C., Balbo, M., Balmaverde, B., Larriva, A. Baquero, Martins, V. Barbosa, Barkov, M., Baroncelli, L., de Almeida, U. Barres, Barrio, J. A., Batista, P., Becerra, J., Becherini, Y., Beck, G., Tjus, J. Becker, Belmont, R., Benbow, W., Bernardini, E., Berti, A., Berton, M., Bertucci, B., Beshley, V., Bi, B., Biasuzzi, B., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Bocchino, F., Boisson, C., Bolmont, J., Bonanno, G., Arbeletche, L. Bonneau, Bonnoli, G., Bordas, P., Bottacini, E., Böttcher, M., Bozhilov, V., Bregeon, J., Brill, A., Brown, A. M., Bruno, P., Bruno, A., Bulgarelli, A., Burton, M., Buscemi, M., Caccianiga, A., Cameron, R., Capasso, M., Caprai, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Carosi, R., Carosi, A., Casanova, S., Cascone, E., Cauz, D., Cerny, K., Cerruti, M., Chadwick, P., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Chiavassa, A., Chytka, L., Conforti, V., Conte, F., Contreras, J. L., Coronado-Blazquez, J., Cortina, J., Costa, A., Costantini, H., Covino, S., Cristofari, P., Cuevas, O., D'Ammando, F., Daniel, M. K., Davies, J., Dazzi, F., De Angelis, A., de Lavergne, M. de Bony, De Caprio, V., Anjos, R. de Cássia dos, Pino, E. M. de Gouveia Dal, De Lotto, B., De Martino, D., de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., de Souza, V., Delgado, C., Della Ceca, R., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Pierro, F., Díaz, C., Díaz-Bahamondes, C., Diebold, S., Djannati-Ataï, A., Dmytriiev, A., Domínguez, A., Donini, A., Dorner, D., Doro, M., Dournaux, J., Dwarkadas, V. V., Ebr, J., Eckner, C., Einecke, S., Ekoume, T. R. N., Elsässer, D., Emery, G., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Fegan, S., Feng, Q., Ferrand, G., Fiandrini, E., Fiasson, A., Fioretti, V., Foffano, L., Fonseca, M. V., Font, L., Fontaine, G., Franco, F. J., Coromina, L. Freixas, Fukami, S., Fukazawa, Y., Fukui, Y., Gaggero, D., Galanti, G., Gammaldi, V., Garcia, E., Garczarczyk, M., Gascon, D., Gaug, M., Gent, A., Ghalumyan, A., Ghirlanda, G., Gianotti, F., Giarrusso, M., Giavitto, G., Giglietto, N., Giordano, F., Glicenstein, J., Goldoni, P., González, J. M., Gourgouliatos, K., Grabarczyk, T., Grandi, P., Granot, J., Grasso, D., Green, J., Grube, J., Gueta, O., Gunji, S., Halim, A., Harvey, M., Collado, T. Hassan, Hayashi, K., Heller, M., Cadena, S. Hernández, Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Hughes, G., Hütten, M., Iarlori, M., Inada, T., Inoue, S., Insolia, A., Ionica, M., Iori, M., Jacquemont, M., Jamrozy, M., Janecek, P., Martínez, I. Jiménez, Jin, W., Jung-Richardt, I., Jurysek, J., Kaaret, P., Karas, V., Karkar, S., Kawanaka, N., Kerszberg, D., Khélifi, B., Kissmann, R., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kong, A., Kosack, K., Kubo, H., La Palombara, N., Lamanna, G., Lang, R. G., Lapington, J., Laporte, P., Lemoine-Goumard, M., Lenain, J., Leone, F., Leto, G., Leuschner, F., Lindfors, E., Lloyd, S., Lohse, T., Lombardi, S., Longo, F., Lopez, A., López, M., López-Coto, R., Loporchio, S., Lucarelli, F., Luque-Escamilla, P. L., Lyard, E., Maggio, C., Majczyna, A., Makariev, M., Mallamaci, M., Mandat, D., Maneva, G., Manganaro, M., Manicò, G., Marcowith, A., Marculewicz, M., Markoff, S., Marquez, P., Martí, J., Martinez, O., Martínez, M., Martínez, G., Martínez-Huerta, H., Maurin, G., Mazin, D., Mbarubucyeye, J. D., Miranda, D. Medina, Meyer, M., Micanovic, S., Miener, T., Minev, M., Miranda, J. M., Mitchell, A., Mizuno, T., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Montaruli, T., Moralejo, A., Merino, J. Morales, Morcuende-Parrilla, D., Morselli, A., Mukherjee, R., Mundell, C., Murach, T., Muraishi, H., Nagai, A., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nievas, M., Nikołajuk, M., Nishijima, K., Noda, K., Nosek, D., Nozaki, S., O'Brien, P., Ohira, Y., Ohishi, M., Oka, T., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Osborne, J. P., Ostrowski, M., Oya, I., Pagliaro, A., Palatka, M., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pavletić, L., Pe'er, A., Pech, M., Pecimotika, M., Peresano, M., Persic, M., Petruk, O., Pfrang, K., Piatteli, P., Pietropaolo, E., Pillera, R., Pilszyk, B., Pimentel, D., Pintore, F., Pita, S., Pohl, M., Poireau, V., Polo, M., Prado, R. R., Prast, J., Principe, G., Produit, N., Prokoph, H., Prouza, M., Przybilski, H., Pueschel, E., Pühlhofer, G., Pumo, M. L., Punch, M., Queiroz, F., Quirrenbach, A., Rando, R., Razzaque, S., Rebert, E., Recchia, S., Reichherzer, P., Reimer, O., Reimer, A., Renier, Y., Reposeur, T., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Ramirez, J. C. Rodriguez, Vázquez, J. J. Rodríguez, Romano, P., Romeo, G., Roncadelli, M., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Rujopakarn, W., Russo, F., Sadeh, I., Saha, L., Saito, T., Greus, F. Salesa, Sanchez, D., Sánchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santos, E. M., Sanuy, A., Sarkar, S., Saturni, F. G., Sawangwit, U., Scherer, A., Schleicher, B., Schovanek, P., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Arroyo, M. Seglar, Sergijenko, O., Servillat, M., Seweryn, K., Shalchi, A., Sharma, P., Shellard, R. C., Siejkowski, H., Sinha, A., Sliusar, V., Slowikowska, A., Sokolenko, A., Sol, H., Specovius, A., Spencer, S., Spiga, D., Stamerra, A., Stanič, S., Starling, R., Stolarczyk, T., Straumann, U., Strišković, J., Suda, Y., Świerk, P., Tagliaferri, G., Takahashi, H., Takahashi, M., Tavecchio, F., Taylor, L., Tejedor, L. A., Temnikov, P., Terrier, R., Terzic, T., Testa, V., Tian, W., Tibaldo, L., Tonev, D., Torres, D. F., Torresi, E., Tosti, L., Tothill, N., Tovmassian, G., Travnicek, P., Truzzi, S., Tuossenel, F., Umana, G., Vacula, M., Vagelli, V., Valentino, M., Vallage, B., Vallania, P., van Eldik, C., Varner, G. S., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Veh, J., Vercellone, S., Vergani, S., Verguilov, V., Vettolani, G. P., Viana, A., Vigorito, C. F., Vitale, V., Vorobiov, S., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Watson, J., White, M., White, R., Wiemann, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Wolter, A., Yamazaki, R., Yanagita, S., Yang, L., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zaric, D., Zavrtanik, M., Zavrtanik, D., Zech, A., Zechlin, H., Zhdanov, V. I., and Živec, M.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Cherenkov Telescope Array (CTA), the new-generation ground-based observatory for $\gamma$-ray astronomy, provides unique capabilities to address significant open questions in astrophysics, cosmology, and fundamental physics. We study some of the salient areas of $\gamma$-ray cosmology that can be explored as part of the Key Science Projects of CTA, through simulated observations of active galactic nuclei (AGN) and of their relativistic jets. Observations of AGN with CTA will enable a measurement of $\gamma$-ray absorption on the extragalactic background light with a statistical uncertainty below 15% up to a redshift $z=2$ and to constrain or detect $\gamma$-ray halos up to intergalactic-magnetic-field strengths of at least 0.3pG. Extragalactic observations with CTA also show promising potential to probe physics beyond the Standard Model. The best limits on Lorentz invariance violation from $\gamma$-ray astronomy will be improved by a factor of at least two to three. CTA will also probe the parameter space in which axion-like particles could constitute a significant fraction, if not all, of dark matter. We conclude on the synergies between CTA and other upcoming facilities that will foster the growth of $\gamma$-ray cosmology., Comment: 71 pages (including affiliations and references), 13 figures, 6 tables. Accepted in JCAP; matches published version. Corresponding authors: Jonathan Biteau, Julien Lefaucheur, Humberto Martinez-Huerta, Manuel Meyer, Santiago Pita, Ievgen Vovk
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- 2020
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97. Sensitivity of the Cherenkov Telescope Array to a dark matter signal from the Galactic centre
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Consortium, The Cherenkov Telescope Array, Acharyya, A., Adam, R., Adams, C., Agudo, I., Aguirre-Santaella, A., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Batista, R. Alves, Amati, L., Ambrosi, G., Angüner, E. O., Antonelli, L. A., Aramo, C., Araudo, A., Armstrong, T., Arqueros, F., Asano, K., Ascasíbar, Y., Ashley, M., Balazs, C., Ballester, O., Larriva, A. Baquero, Martins, V. Barbosa, Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Becerra, J., Beck, G., Tjus, J. Becker, Benbow, W., Benito, M., Berge, D., Bernardini, E., Bernlöhr, K., Berti, A., Bertucci, B., Beshley, V., Biasuzzi, B., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Arbeletche, L. Bonneau, Bordas, P., Bosnjak, Z., Bottacini, E., Bozhilov, V., Bregeon, J., Brill, A., Bringmann, T., Brown, A. M., Brun, P., Brun, F., Bruno, P., Bulgarelli, A., Burton, M., Burtovoi, A., Buscemi, M., Cameron, R., Capasso, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Carosi, R., Carosi, A., Casanova, S., Cascone, E., Cassol, F., Catalani, F., Cauz, D., Cerruti, M., Chadwick, P., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Chiavassa, A., Chikawa, M., Chudoba, J., Çolak, M., Conforti, V., Coniglione, R., Conte, F., Contreras, J. L., Coronado-Blazquez, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., D'Aì, A., D'Ammando, F., Damone, L. A., Daniel, M. K., Dazzi, F., De Angelis, A., De Caprio, V., Anjos, R. de Cássia dos, Pino, E. M. de Gouveia Dal, De Lotto, B., De Martino, D., Wilhelmi, E. de Oña, De Palma, F., de Souza, V., Delgado, C., Giler, A. G. Delgado, della Volpe, D., Depaoli, D., Di Girolamo, T., Di Pierro, F., Di Venere, L., Diebold, S., Dmytriiev, A., Domínguez, A., Donini, A., Doro, M., Ebr, J., Eckner, C., Edwards, T. D. P., Ekoume, T. R. N., Elsässer, D., Evoli, C., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrara, G., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Fontaine, G., Fornieri, O., Franco, F. J., Fukami, S., Fukui, Y., Gaggero, D., Galaz, G., Gammaldi, V., Garcia, E., Garczarczyk, M., Gascon, D., Gent, A., Ghalumyan, A., Gianotti, F., Giarrusso, M., Giavitto, G., Giglietto, N., Giordano, F., Giuliani, A., Glicenstein, J., Gnatyk, R., Goldoni, P., González, M. M., Gourgouliatos, K., Granot, J., Grasso, D., Green, J., Grillo, A., Gueta, O., Gunji, S., Halim, A., Hassan, T., Heller, M., Cadena, S. Hernández, Hiroshima, N., Hnatyk, B., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Hughes, G., Humensky, T. B., Hütten, M., Iarlori, M., Inada, T., Inoue, S., Iocco, F., Iori, M., Jamrozy, M., Janecek, P., Jin, W., Jouvin, L., Jurysek, J., Karukes, E., Katarzyński, K., Kazanas, D., Kerszberg, D., Kherlakian, M. C., Kissmann, R., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kubo, H., Kushida, J., Lamanna, G., Lapington, J., Laporte, P., de Oliveira, M. A. Leigui, Lenain, J., Leone, F., Leto, G., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., Lopez, A., López, M., López-Coto, R., Loporchio, S., Luque-Escamilla, P. L., Mach, E., Maggio, C., Maier, G., Mallamaci, M., de Almeida, R. Malta Nunes, Mandat, D., Manganaro, M., Mangano, S., Manicò, G., Marculewicz, M., Mariotti, M., Markoff, S., Marquez, P., Martí, J., Martinez, O., Martínez, M., Martínez, G., Martínez-Huerta, H., Maurin, G., Mazin, D., Mbarubucyeye, J. D., Miranda, D. Medina, Meyer, M., Miceli, M., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Mizuno, T., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Montaruli, T., Moralejo, A., Morcuende-Parrilla, D., Morselli, A., Mukherjee, R., Mundell, C., Nagai, A., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nikołajuk, M., Ninci, D., Noda, K., Nosek, D., Nozaki, S., Ohira, Y., Ohishi, M., Ohtani, Y., Oka, T., Okumura, A., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, S., Orlando, E., Ostrowski, M., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Pantaleo, F. R., Paredes, J. M., Pareschi, G., Parmiggiani, N., Patricelli, B., Pavletić, L., Pe'er, A., Pecimotika, M., Pérez-Romero, J., Persic, M., Petruk, O., Pfrang, K., Piano, G., Piatteli, P., Pietropaolo, E., Pillera, R., Pilszyk, B., Pintore, F., Pohl, M., Poireau, V., Prado, R. R., Prandini, E., Prast, J., Principe, G., Prokoph, H., Prouza, M., Przybilski, H., Pühlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Recchia, S., Reimer, O., Reisenegger, A., Renier, Y., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Rinchiuso, L., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Ramirez, J. C. Rodriguez, Rojas, G., Romano, P., Romeo, G., Rosado, J., Rowell, G., Rudak, B., Russo, F., Sadeh, I., Hatlen, E. Sæther, Safi-Harb, S., Greus, F. Salesa, Salina, G., Sanchez, D., Sánchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santos, E. M., Santos-Lima, R., Sanuy, A., Sarkar, S., Saturni, F. G., Sawangwit, U., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Seglar-Arroyo, M., Sergijenko, O., Servillat, M., Seweryn, K., Shalchi, A., Sharma, P., Shellard, R. C., Siejkowski, H., Silk, J., Siqueira, C., Sliusar, V., Słowikowska, A., Sokolenko, A., Sol, H., Spencer, S., Stamerra, A., Stanič, S., Starling, R., Stolarczyk, T., Straumann, U., Strišković, J., Suda, Y., Suomijarvi, T., Świerk, P., Tavecchio, F., Taylor, L., Tejedor, L. A., Teshima, M., Testa, V., Tibaldo, L., Peixoto, C. J. Todero, Tokanai, F., Tonev, D., Tosti, G., Tosti, L., Tothill, N., Truzzi, S., Travnicek, P., Vagelli, V., Vallage, B., Vallania, P., van Eldik, C., Vandenbroucke, J., Varner, G. S., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Vergani, S., Verna, G., Viana, A., Vigorito, C. F., Vink, J., Vitale, V., Vorobiov, S., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Watson, J., Weniger, C., White, R., White, M., Wiemann, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Yanagita, S., Yang, L., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zakaria, A. A., Zampieri, L., Zanin, R., Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., and Živec, M.
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Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Phenomenology - Abstract
We provide an updated assessment of the power of the Cherenkov Telescope Array (CTA) to search for thermally produced dark matter at the TeV scale, via the associated gamma-ray signal from pair-annihilating dark matter particles in the region around the Galactic centre. We find that CTA will open a new window of discovery potential, significantly extending the range of robustly testable models given a standard cuspy profile of the dark matter density distribution. Importantly, even for a cored profile, the projected sensitivity of CTA will be sufficient to probe various well-motivated models of thermally produced dark matter at the TeV scale. This is due to CTA's unprecedented sensitivity, angular and energy resolutions, and the planned observational strategy. The survey of the inner Galaxy will cover a much larger region than corresponding previous observational campaigns with imaging atmospheric Cherenkov telescopes. CTA will map with unprecedented precision the large-scale diffuse emission in high-energy gamma rays, constituting a background for dark matter searches for which we adopt state-of-the-art models based on current data. Throughout our analysis, we use up-to-date event reconstruction Monte Carlo tools developed by the CTA consortium, and pay special attention to quantifying the level of instrumental systematic uncertainties, as well as background template systematic errors, required to probe thermally produced dark matter at these energies. "Full likelihood tables complementing our analysis are provided here [ https://doi.org/10.5281/zenodo.4057987 ]", Comment: 68 pages (including references) and 26 figures; text identical to the version published in JCAP
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- 2020
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98. AGILESim: Monte Carlo simulation of the AGILE gamma-ray telescope
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Fioretti, V., Bulgarelli, A., Tavani, M., Sabatini, S., Aboudan, A., Argan, A., Cattaneo, P. W., Chen, A. W., Donnarumma, I., Longo, F., Galli, M., Giuliani, A., Marisaldi, M., Parmiggiani, N., and Rappoldi, A.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The accuracy of Monte Carlo simulations in reproducing the scientific performance of space telescopes (e.g. angular resolution) is mandatory for a correct design of the mission. A brand-new Monte Carlo simulator of the Astrorivelatore Gamma ad Immagini LEggero (AGILE)/Gamma-Ray Imaging Detector (GRID) space telescope, AGILESim, is built using the customizable Bologna Geant4 Multi-Mission Simulator (BoGEMMS) architecture and the latest Geant4 library to reproduce the instrument performance of the AGILE/GRID instrument. The Monte Carlo simulation output is digitized in the BoGEMMS postprocessing pipeline, according to the instrument electronic read-out logic, then converted into the onboard data handling format, and finally analyzed by the standard mission on-ground reconstruction pipeline, including the Kalman filter, as a real observation in space. In this paper we focus on the scientific validation of AGILESim, performed by reproducing (i) the conversion efficiency of the tracker planes, (ii) the tracker charge readout distribution measured by the on-ground assembly, integration, and verification activity, and (iii) the point-spread function of in-flight observations of the Vela pulsar in the 100 MeV - 1 GeV energy range. We measure an in-flight angular resolution (FWHM) for Vela-like point sources of $2.0^{+0.2}_{-0.3}$ and $0.8^{+0.1}_{-0.1}$ degrees in the 100 - 300 and 300 - 1000 MeV energy bands, respectively. The successful cross-comparison of the simulation results with the AGILE on-ground and in-space performance validates the BoGEMMS framework for its application to future gamma-ray trackers (e.g. e-ASTROGAM and AMEGO).
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- 2020
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99. Observation of inverse Compton emission from a long $\gamma$-ray burst
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Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Baack, D., Babić, A., Banerjee, B., de Almeida, U. Barres, Barrio, J. A., González, J. Becerra, Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. Fallah, Fattorini, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinović, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., López-Oramas, A., Loporchio, S., Fraga, B. Machado de Oliveira, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Mićanović, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Nozaki, S., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Peñil, P., Peresano, M., Persic, M., Moroni, P. G. Prada, Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tosti, L., Vagelli, V., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zarić, D., Nava, L., Veres, P., Bhat, P. N., Briggs, M. S., Cleveland, W. H., Hamburg, R., Hui, C. M., Mailyan, B., Preece, R. D., Roberts, O., von Kienlin, A., Wilson-Hodge, C. A., Kocevski, D., Arimoto, M., Tak, D., Asano, K., Axelsson, M., Barbiellini, G., Bissaldi, E., Dirirsa, F. Fana, Gill, R., Granot, J., McEnery, J., Razzaque, S., Piron, F., Racusin, J. L., Thompson, D. J., Campana, S., Bernardini, M. G., Kuin, N. P. M., Siegel, M. H., Cenko, S. Bradley, O'Brien, P., Capalbi, M., D'Aì, A., De Pasquale, M., Gropp, J., Klingler, N., Osborne, J. P., Perri, M., Starling, R., Tagliaferri, G., Tohuvavohu, A., Ursi, A., Tavani, M., Cardillo, M., Casentini, C., Piano, G., Evangelista, Y., Verrecchia, F., Pittori, C., Lucarelli, F., Bulgarelli, A., Parmiggiani, N., Anderson, G. E., Anderson, J. P., Bernardi, G., Bolmer, J., Caballero-García, M. D., Carrasco, I. M., Castellón, A., Segura, N. Castro, Castro-Tirado, A. J., Cherukuri, S. V., Cockeram, A. M., D'Avanzo, P., Di Dato, A., Diretse, R., Fender, R. P., Fernández-García, E., Fynbo, J. P. U., Fruchter, A. S., Greiner, J., Gromadzki, M., Heintz, K. E., Heywood, I., van der Horst, A. J., Hu, Y. -D., Inserra, C., Izzo, L., Jaiswal, V., Jakobsson, P., Japelj, J., Kankare, E., Kann, D. A., Kouveliotou, C., Klose, S., Levan, A. J., Li, X. Y., Lotti, S., Maguire, K., Malesani, D. B., Manulis, I., Marongiu, M., Martin, S., Melandri, A., Michałowski, M., Miller-Jones, J. C. A., Misra, K., Moin, A., Mooley, K. P., Nasri, S., Nicholl, M., Noschese, A., Novara, G., Pandey, S. B., Peretti, E., del Pulgar, C. J. Pérez, Pérez-Torres, M. A., Perley, D. A., Piro, L., Ragosta, F., Resmi, L., Ricci, R., Rossi, A., Sánchez-Ramírez, R., Selsing, J., Schulze, S., Smartt, S. J., Smith, I. A., Sokolov, V. V., Stevens, J., Tanvir, N. R., Thóne, C. C., Tiengo, A., Tremou, E., Troja, E., Postigo, A. de Ugarte, Vergani, S. D., Wieringa, M., Woudt, P. A., Xu, D., Yaron, O., and Young, D. R.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Long-duration gamma-ray bursts (GRBs) originate from ultra-relativistic jets launched from the collapsing cores of dying massive stars. They are characterised by an initial phase of bright and highly variable radiation in the keV-MeV band that is likely produced within the jet and lasts from milliseconds to minutes, known as the prompt emission. Subsequently, the interaction of the jet with the external medium generates external shock waves, responsible for the afterglow emission, which lasts from days to months, and occurs over a broad energy range, from the radio to the GeV bands. The afterglow emission is generally well explained as synchrotron radiation by electrons accelerated at the external shock. Recently, an intense, long-lasting emission between 0.2 and 1 TeV was observed from the GRB 190114C. Here we present the results of our multi-frequency observational campaign of GRB~190114C, and study the evolution in time of the GRB emission across 17 orders of magnitude in energy, from $5\times10^{-6}$ up to $10^{12}$\,eV. We find that the broadband spectral energy distribution is double-peaked, with the TeV emission constituting a distinct spectral component that has power comparable to the synchrotron component. This component is associated with the afterglow, and is satisfactorily explained by inverse Compton upscattering of synchrotron photons by high-energy electrons. We find that the conditions required to account for the observed TeV component are not atypical, supporting the possibility that inverse Compton emission is commonly produced in GRBs.
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- 2020
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100. An X-Ray Burst from a Magnetar Enlightening the Mechanism of Fast Radio Bursts
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Tavani, M., Casentini, C., Ursi, A., Verrecchia, F., Addis, A., Antonelli, L. A., Argan, A., Barbiellini, G., Baroncelli, L., Bernardi, G., Bianchi, G., Bulgarelli, A., Caraveo, P., Cardillo, M., Cattaneo, P. W., Chen, A. W., Costa, E., Del Monte, E., Di Cocco, G., Di Persio, G., Donnarumma, I., Evangelista, Y., Feroci, M., Ferrari, A., Fioretti, V., Fuschino, F., Galli, M., Gianotti, F., Giuliani, A., Labanti, C., Lazzarotto, F., Lipari, P., Longo, F., Lucarelli, F., Magro, A., Marisaldi, M., Mereghetti, S., Morelli, E., Morselli, A., Naldi, G., Pacciani, L., Parmiggiani, N., Paoletti, F., Pellizzoni, A., Perri, M., Perotti, F., Piano, G., Picozza, P., Pilia, M., Pittori, C., Puccetti, S., Pupillo, G., Rapisarda, M., Rappoldi, A., Rubini, A., Setti, G., Soffitta, P., Trifoglio, M., Trois, A., Vercellone, S., Vittorini, V., Giommi, P., and Amico, F. D'
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Fast radio bursts (FRBs) are short (millisecond) radio pulses originating from enigmatic sources at extragalactic distances so far lacking a detection in other energy bands. Magnetized neutron stars (magnetars) have been considered as the sources powering the FRBs, but the connection is controversial because of differing energetics and the lack of radio and X-ray detections with similar characteristics in the two classes. We report here the detection by the AGILE satellite on April 28, 2020 of an X-ray burst in coincidence with the very bright radio burst from the Galactic magnetar SGR 1935+2154. The burst detected by AGILE in the hard X-ray band (18-60 keV) lasts about 0.5 seconds, it is spectrally cutoff above 80 keV, and implies an isotropically emitted energy ~ $10^{40}$ erg. This event is remarkable in many ways: it shows for the first time that a magnetar can produce X-ray bursts in coincidence with FRB-like radio bursts; it also suggests that FRBs associated with magnetars may emit X-ray bursts of both magnetospheric and radio-pulse types that may be discovered in nearby sources. Guided by this detection, we discuss SGR 1935+2154 in the context of FRBs, and especially focus on the class of repeating-FRBs. Based on energetics, magnetars with fields B ~ $10^{15}$ G may power the majority of repeating-FRBs. Nearby repeating-FRBs offer a unique occasion to consolidate the FRB-magnetar connection, and we present new data on the X-ray monitoring of nearby FRBs. Our detection enlightens and constrains the physical process leading to FRBs: contrary to previous expectations, high-brightness temperature radio emission coexists with spectrally-cutoff X-ray radiation., Comment: Submitted to Nature Astronomy, May 18, 2020
- Published
- 2020
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