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278 results on '"Bukholm, Geir"'

52. Supplementary Materials: In Silico Structure and Sequence Analysis of Bacterial Porins and Specific Diffusion Channels for Hydrophilic Molecules: Conservation, Multimericity, and Multifunctionality.

Author

Vollan, Hilde S., Tannæs, Tone, Vriend, Gert, and Bukholm, Geir

Subjects
PORINS (Proteins), HYDROPHILIC interactions, OMPA protein, BACTERIAL protein structure, DIFFUSION processes
Abstract

The article focuses on the structure and sequence analysis of bacterial porins and specific diffusion channels for hydrophilic molecules. It offers information related to eight subclass of the porins, based on structure, function and multimeric state. It mentions that class 1A is composed of the smallest porins which are non-specific and include the OmpA porins which are abundant multifunctional porins involved in host evasion, binding to receptors and having nonspecific pore activity.

Published
2016
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84. Distribution of methicillin-resistant Staphylococcus aureus in a low-prevalence area.

Author

Moen, Aina Elisabeth Fossum, Storla, Dag Gundersen, and Bukholm, Geir

Subjects
METHICILLIN-resistant staphylococcus aureus, PATHOGENIC microorganisms, STAPHYLOCOCCUS aureus infections, GENES, GENERAL practitioners
Abstract

Investigating circulating methicillin-resistant Staphylococcus aureus (MRSA) strains and identifying their accumulations in society are important in the search for strategies for eradicating the pathogen. The aim of this study was to describe the distribution of MRSA in a low-prevalence area where MRSA could be establishing endemicity. MRSA isolates from 802 patients (803 isolates) were included and placed into a timeline (1991–2006) under different categories: hospital ( n=270), long-term care facility (LTCF) ( n=175) and general practitioner (GP) ( n=358). MRSA isolates had been characterized using multilocus sequence-typing, staphylococcal cassette chromosome mec-typing and detection of Panton–Valentine leukocidin-encoding genes ( lukS/ F-PVL), and were placed in exotoxin-encoding gene clusters. The GP category increased mainly in a cluster with few exotoxin-encoding genes ( r=0.760), the LTCF ( r=0.804) and the hospital category ( r=0.876) mainly in clusters with more exotoxin-encoding genes. ST8-IV, lukS/ F-PVL present, increased in the community (1–41 isolates) in the time period 2002–2006, later in the hospital (1–8 isolates, 2004–2006), and finally reached the LTCF (1 isolate, 2006). ST8-IV, lukS/ F-PVL absent, could have attained endemicity in LTCFs, where 51 isolates were isolated in 2006. ST125-IV, lukS/ F-PVL absent, showing epidemic qualities abroad, caused outbreaks at five LTCFs. [ABSTRACT FROM AUTHOR]

Published
2010
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87. Cholesteryl-6-O-acyl-α-d-glucopyranoside of Helicobacter pylori relate to relative lysophospholipid content

Author

Tannæs, Tone and Bukholm, Geir

Subjects
*HELICOBACTER pylori, *GLYCOSIDES, *CARBOHYDRATES, *CHROMATOGRAPHIC analysis
Abstract

Abstract: The presence of cholesteryl glucosides and high levels of lysophospholipids are elements making the cell wall of Helicobacter pylori unique. In this study, we have investigated the relationship between lysophospholipid content and cholesteryl glucoside composition of variants of 6 clinical isolates. The samples were characterized by diverse outer membrane phospholipase A activity measured as lysophospholipid content of the cell wall. A pldA negative mutant was also included in the study. Thin-layer chromatography showed that cholesteryl glucosides were present in all samples. However, the distribution of cholesteryl-6-O-acyl-α-d-glucopyranoside, cholesteryl-α-d-glucopyranoside and cholesteryl-6-O-phosphatidyl-α-d-glucopyranoside varied according to lysophospholipid content. Cholesteryl-6-O-acyl-α-d-glucopyranoside was exclusively observed in the isolates/variants with an intact pldA and where a significant amount of lysophospholipids could be demonstrated. High lysophospholipid content destabilizes membranes. The balance between cholesteryl-6-O-acyl-α-d-glucopyranoside, cholesteryl-α-d-glucopyranoside and cholesteryl-6-O-phosphatidyl-α-d-glucopyranoside in H. pylori is probably important for the stability of the membrane when the lysophospholipid content varies. [Copyright &y& Elsevier]

Published
2005
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