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55. Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Author

Bogl, LH, Jelenkovic, A, Vuoksimaa, E, Ahrenfeldt, L, Pietilainen, KH, Stazi, MA, Fagnani, C, D'Ippolito, C, Hur, Y-M, Jeong, H-U, Silberg, JL, Eaves, LJ, Maes, HH, Bayasgalan, G, Narandalai, D, Cutler, TL, Kandler, C, Jang, KL, Christensen, K, Skytthe, A, Kyvik, KO, Cozen, W, Hwang, AE, Mack, TM, Derom, CA, Vlietinck, RF, Nelson, TL, Whitfield, KE, Corley, RP, Huibregtse, BM, McAdams, TA, Eley, TC, Gregory, AM, Krueger, RF, Mcgue, M, Pahlen, S, Willemsen, G, Bartels, M, van Beijsterveldt, TCEM, Pang, Z, Tan, Q, Zhang, D, Martin, NG, Medland, SE, Montgomery, GW, Hjelmborg, JVB, Rebato, E, Swan, GE, Krasnow, R, Busjahn, A, Lichtenstein, P, Oncel, SY, Aliev, F, Baker, LA, Tuvblad, C, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Magnusson, PKE, Pedersen, NL, Aslan, AKD, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Duncan, GE, Buchwald, D, Tarnoki, AD, Tarnoki, DL, Yokoyama, Y, Hopper, JL, Loos, RJF, Boomsma, DI, Sorensen, TIA, Silventoinen, K, Kaprio, J, Bogl, LH, Jelenkovic, A, Vuoksimaa, E, Ahrenfeldt, L, Pietilainen, KH, Stazi, MA, Fagnani, C, D'Ippolito, C, Hur, Y-M, Jeong, H-U, Silberg, JL, Eaves, LJ, Maes, HH, Bayasgalan, G, Narandalai, D, Cutler, TL, Kandler, C, Jang, KL, Christensen, K, Skytthe, A, Kyvik, KO, Cozen, W, Hwang, AE, Mack, TM, Derom, CA, Vlietinck, RF, Nelson, TL, Whitfield, KE, Corley, RP, Huibregtse, BM, McAdams, TA, Eley, TC, Gregory, AM, Krueger, RF, Mcgue, M, Pahlen, S, Willemsen, G, Bartels, M, van Beijsterveldt, TCEM, Pang, Z, Tan, Q, Zhang, D, Martin, NG, Medland, SE, Montgomery, GW, Hjelmborg, JVB, Rebato, E, Swan, GE, Krasnow, R, Busjahn, A, Lichtenstein, P, Oncel, SY, Aliev, F, Baker, LA, Tuvblad, C, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Magnusson, PKE, Pedersen, NL, Aslan, AKD, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Duncan, GE, Buchwald, D, Tarnoki, AD, Tarnoki, DL, Yokoyama, Y, Hopper, JL, Loos, RJF, Boomsma, DI, Sorensen, TIA, Silventoinen, K, and Kaprio, J

Abstract

BACKGROUND: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric traits, we compared mean height, body mass index (BMI), and the prevalence of being overweight or obese between men and women from OS and SS dizygotic twin pairs. METHODS: The data were derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) database, and included 68,494 SS and 53,808 OS dizygotic twin individuals above the age of 20 years from 31 twin cohorts representing 19 countries. Zygosity was determined by questionnaires or DNA genotyping depending on the study. Multiple regression and logistic regression models adjusted for cohort, age, and birth year with the twin type as a predictor were carried out to compare height and BMI in twins from OS pairs with those from SS pairs and to calculate the adjusted odds ratios and 95% confidence intervals for being overweight or obese. RESULTS: OS females were, on average, 0.31 cm (95% confidence interval (CI) 0.20, 0.41) taller than SS females. OS males were also, on average, taller than SS males, but this difference was only 0.14 cm (95% CI 0.02, 0.27). Mean BMI and the prevalence of overweight or obesity did not differ between males and females from SS and OS twin pairs. The statistically significant differences between OS and SS twins for height were small and appeared to reflect our large sample size rather than meaningful differences of public health relevance. CONCLUSIONS: We found no evidence to support the hypothesis that prenatal hormonal exposure or postnatal socialization (i.e., having grown up with a twin of the opposite sex) has a major impact on height and BMI in adulthood.

Published
2017

56. Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region : An individual-based pooled analysis of 40 twin cohorts

Author

Silventoinen, K., Jelenkovic, A., Sund, R., Yokoyama, Y., Hur, Y. -M, Cozen, W., Hwang, A. E., Mack, T. M., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Tomizawa, R., Pietilainen, K. H., Rissanen, A., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, Z., Piirtola, M., Aaltonen, S., Oncel, S. Y., Aliev, F., Rebato, E., Hjelmborg, J. B., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Cutler, T. L., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Song, Y. -M, Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D'Ippolito, C., Duncan, G. E., Buchwald, D., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. -U, Swan, G. E., Krasnow, R., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, Anna K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Spector, T. D., Mangino, M., Lachance, G., Burt, S. A., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Huibregtse, B. M., Bartels, M., Van Beijsterveldt, C. E. M., Willemsen, G., Goldberg, J. H., Rasmussen, F., Tarnoki, A. D., Tarnoki, D. L., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Hopper, J. L., Sung, J., Maes, H. H., Turkheimer, E., Boomsma, D. I., Sørensen, T. I. A., Kaprio, J., Silventoinen, K., Jelenkovic, A., Sund, R., Yokoyama, Y., Hur, Y. -M, Cozen, W., Hwang, A. E., Mack, T. M., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Tomizawa, R., Pietilainen, K. H., Rissanen, A., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, Z., Piirtola, M., Aaltonen, S., Oncel, S. Y., Aliev, F., Rebato, E., Hjelmborg, J. B., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Cutler, T. L., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Song, Y. -M, Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D'Ippolito, C., Duncan, G. E., Buchwald, D., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. -U, Swan, G. E., Krasnow, R., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, Anna K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Spector, T. D., Mangino, M., Lachance, G., Burt, S. A., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Huibregtse, B. M., Bartels, M., Van Beijsterveldt, C. E. M., Willemsen, G., Goldberg, J. H., Rasmussen, F., Tarnoki, A. D., Tarnoki, D. L., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Hopper, J. L., Sung, J., Maes, H. H., Turkheimer, E., Boomsma, D. I., Sørensen, T. I. A., and Kaprio, J.

Abstract

Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m2)], but factors modifying these variance components are poorly understood. Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity. Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs). Results: The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 20-29 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI. Conclusions: The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.

Published
2017
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58. Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Author

Jelenkovic, A., Hur, Y. -M, Sund, R., Yokoyama, Y., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, Z., Aaltonen, S., Heikkilä, K., Öncel, S.Y., Aliev, F., Rebato, E., Tarnoki, A. D., Tarnoki, D. L., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Cozen, W., Hwang, A. E., Mack, T. M., Sung, J., Song, Y. -M, Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D’Ippolito, C., Duncan, G. E., Buchwald, D., Derom, C. A., Vlietinck, R. F., Loos, R. J., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. -U, Swan, G. E., Krasnow, R., Magnusson, P. K., Pedersen, N. L., Dahl-Aslan, Anna K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Lichtenstein, P., Spector, T. D., Mangino, M., Lachance, G., Bartels, M., Van Beijsterveldt, T. C., Willemsen, G., Alexandra Burt, S., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Hjelmborg, J. V. B., Goldberg, J. H., Iwatani, Y., Watanabe, M., Honda, C., Inui, F., Rasmussen, F., Huibregtse, B. M., Boomsma, D. I., Sørensen, T. I. A., Kaprio, J., Silventoinen, K., Jelenkovic, A., Hur, Y. -M, Sund, R., Yokoyama, Y., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, Z., Aaltonen, S., Heikkilä, K., Öncel, S.Y., Aliev, F., Rebato, E., Tarnoki, A. D., Tarnoki, D. L., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Cozen, W., Hwang, A. E., Mack, T. M., Sung, J., Song, Y. -M, Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D’Ippolito, C., Duncan, G. E., Buchwald, D., Derom, C. A., Vlietinck, R. F., Loos, R. J., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. -U, Swan, G. E., Krasnow, R., Magnusson, P. K., Pedersen, N. L., Dahl-Aslan, Anna K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Lichtenstein, P., Spector, T. D., Mangino, M., Lachance, G., Bartels, M., Van Beijsterveldt, T. C., Willemsen, G., Alexandra Burt, S., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Hjelmborg, J. V. B., Goldberg, J. H., Iwatani, Y., Watanabe, M., Honda, C., Inui, F., Rasmussen, F., Huibregtse, B. M., Boomsma, D. I., Sørensen, T. I. A., Kaprio, J., and Silventoinen, K.

Abstract

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

Published
2016
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59. Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Author

University of Helsinki, Department of Social Research, University of Helsinki, Department of Public Health, University of Helsinki, Clinicum, Jelenkovic, Aline, Hur, Yoon-Mi, Sund, Reijo, Yokoyama, Y., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, Z., Aaltonen, Sari, Heikkilä, Kauko, Oncel, S. Y., Aliev, F., Rebato, E., Tarnoki, A. D., Tarnoki, D. L., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Cozen, W., Hwang, A. E., Mack, T. M., Sung, J., Song, Y. M., Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D'Ippolito, C., Duncan, G. E., Buchwald, D., Derom, C. A., Vlietinck, R. F., Loos, R. J., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. U., Swan, G. E., Krasnow, R., Magnusson, P. K., Pedersen, N. L., Dahl-Aslan, A. K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Lichtenstein, P., Spector, T. D., Mangino, M., Lachance, G., Bartels, M., van Beijsterveldt, T. C., Willemsen, G., Burt, S. A., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Hjelmborg, J. V., Goldberg, J. H., Iwatani, Y., Watanabe, M., Honda, C., Inui, F., Rasmussen, F., Huibregtse, B. M., Boomsma, D. I., Sorensen, T. I., Kaprio, Jaakko, Silventoinen, Karri, University of Helsinki, Department of Social Research, University of Helsinki, Department of Public Health, University of Helsinki, Clinicum, Jelenkovic, Aline, Hur, Yoon-Mi, Sund, Reijo, Yokoyama, Y., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, Z., Aaltonen, Sari, Heikkilä, Kauko, Oncel, S. Y., Aliev, F., Rebato, E., Tarnoki, A. D., Tarnoki, D. L., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Cozen, W., Hwang, A. E., Mack, T. M., Sung, J., Song, Y. M., Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D'Ippolito, C., Duncan, G. E., Buchwald, D., Derom, C. A., Vlietinck, R. F., Loos, R. J., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. U., Swan, G. E., Krasnow, R., Magnusson, P. K., Pedersen, N. L., Dahl-Aslan, A. K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Lichtenstein, P., Spector, T. D., Mangino, M., Lachance, G., Bartels, M., van Beijsterveldt, T. C., Willemsen, G., Burt, S. A., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Hjelmborg, J. V., Goldberg, J. H., Iwatani, Y., Watanabe, M., Honda, C., Inui, F., Rasmussen, F., Huibregtse, B. M., Boomsma, D. I., Sorensen, T. I., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

Published
2016

60. Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins)

Author

Silventoinen, K, Jelenkovic, A, Sund, R, Hur, Y-M, Yokoyama, Y, Honda, C, Hjelmborg, JV, Möller, S, Ooki, S, Aaltonen, S, Ji, F, Ning, F, Pang, Z, Rebato, E, Busjahn, A, Kandler, C, Saudino, KJ, Jang, KL, Cozen, W, Hwang, AE, Mack, TM, Gao, W, Yu, C, Li, L, Corley, RP, Huibregtse, BM, Christensen, K, Skytthe, A, Kyvik, KO, Derom, CA, Vlietinck, RF, Loos, RJ, Heikkilä, K, Wardle, J, Llewellyn, CH, Fisher, A, McAdams, TA, Eley, TC, Gregory, AM, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Stazi, MA, Fagnani, C, D'Ippolito, C, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Eaves, LJ, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Bartels, M, van Beijsterveldt, TC, Craig, Jeffrey, Saffery, R, Freitas, DL, Maia, JA, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Chong, Y, Swan, GE, Krasnow, R, Magnusson, PK, Pedersen, NL, Tynelius, P, Lichtenstein, P, Haworth, CM, Plomin, R, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Öncel, SY, Aliev, F, Spector, T, Mangino, M, Lachance, G, Baker, LA, Tuvblad, C, Duncan, GE, Buchwald, D, Willemsen, G, Rasmussen, F, Goldberg, JH, Sørensen, TI, Boomsma, DI, Kaprio, J, Silventoinen, K, Jelenkovic, A, Sund, R, Hur, Y-M, Yokoyama, Y, Honda, C, Hjelmborg, JV, Möller, S, Ooki, S, Aaltonen, S, Ji, F, Ning, F, Pang, Z, Rebato, E, Busjahn, A, Kandler, C, Saudino, KJ, Jang, KL, Cozen, W, Hwang, AE, Mack, TM, Gao, W, Yu, C, Li, L, Corley, RP, Huibregtse, BM, Christensen, K, Skytthe, A, Kyvik, KO, Derom, CA, Vlietinck, RF, Loos, RJ, Heikkilä, K, Wardle, J, Llewellyn, CH, Fisher, A, McAdams, TA, Eley, TC, Gregory, AM, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Stazi, MA, Fagnani, C, D'Ippolito, C, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Eaves, LJ, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Bartels, M, van Beijsterveldt, TC, Craig, Jeffrey, Saffery, R, Freitas, DL, Maia, JA, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Chong, Y, Swan, GE, Krasnow, R, Magnusson, PK, Pedersen, NL, Tynelius, P, Lichtenstein, P, Haworth, CM, Plomin, R, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Öncel, SY, Aliev, F, Spector, T, Mangino, M, Lachance, G, Baker, LA, Tuvblad, C, Duncan, GE, Buchwald, D, Willemsen, G, Rasmussen, F, Goldberg, JH, Sørensen, TI, Boomsma, DI, and Kaprio, J

Published
2016

61. Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Author

Jelenkovic, A, Hur, Y-M, Sund, R, Yokoyama, Y, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Tan, Q, Zhang, D, Pang, Z, Aaltonen, S, Heikkila, K, Oncel, SY, Aliev, F, Rebato, E, Tarnoki, AD, Tarnoki, DL, Christensen, K, Skytthe, A, Kyvik, KO, Silberg, JL, Eaves, LJ, Maes, HH, Cutler, TL, Hopper, JL, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Cozen, W, Hwang, AE, Mack, TM, Sun, J, Song, Y-M, Yang, S, Lee, K, Franz, CE, Kremen, WS, Lyons, MJ, Busjahn, A, Nelson, TL, Whitfield, KE, Kandler, C, Jang, KL, Gatz, M, Butler, DA, Stazi, MA, Fagnani, C, D'Ippolito, C, Duncan, GE, Buchwald, D, Derom, CA, Vlietinck, RF, Loos, RJF, Martin, NG, Medland, SE, Montgomery, GW, Jeong, H-U, Swan, GE, Krasnow, R, Magnusson, PKE, Pedersen, NL, Dahl-Aslan, AK, McAdams, TA, Eley, TC, Gregory, AM, Tynelius, P, Baker, LA, Tuvblad, C, Bayasgalan, G, Narandalai, D, Lichtenstein, P, Spector, TD, Mangino, M, Lachance, G, Bartels, M, van Beijsterveldt, TCEM, Willemsen, G, Burt, SA, Klump, KL, Harris, JR, Brandt, I, Nilsen, TS, Krueger, RF, McGue, M, Pahlen, S, Corley, RP, Hjelmborg, JVB, Goldberg, JH, Iwatani, Y, Watanabe, M, Honda, C, Inui, F, Rasmussen, F, Huibregtse, BM, Boomsma, DI, Sorensen, TIA, Kaprio, J, Silventoinen, K, Jelenkovic, A, Hur, Y-M, Sund, R, Yokoyama, Y, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Tan, Q, Zhang, D, Pang, Z, Aaltonen, S, Heikkila, K, Oncel, SY, Aliev, F, Rebato, E, Tarnoki, AD, Tarnoki, DL, Christensen, K, Skytthe, A, Kyvik, KO, Silberg, JL, Eaves, LJ, Maes, HH, Cutler, TL, Hopper, JL, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Cozen, W, Hwang, AE, Mack, TM, Sun, J, Song, Y-M, Yang, S, Lee, K, Franz, CE, Kremen, WS, Lyons, MJ, Busjahn, A, Nelson, TL, Whitfield, KE, Kandler, C, Jang, KL, Gatz, M, Butler, DA, Stazi, MA, Fagnani, C, D'Ippolito, C, Duncan, GE, Buchwald, D, Derom, CA, Vlietinck, RF, Loos, RJF, Martin, NG, Medland, SE, Montgomery, GW, Jeong, H-U, Swan, GE, Krasnow, R, Magnusson, PKE, Pedersen, NL, Dahl-Aslan, AK, McAdams, TA, Eley, TC, Gregory, AM, Tynelius, P, Baker, LA, Tuvblad, C, Bayasgalan, G, Narandalai, D, Lichtenstein, P, Spector, TD, Mangino, M, Lachance, G, Bartels, M, van Beijsterveldt, TCEM, Willemsen, G, Burt, SA, Klump, KL, Harris, JR, Brandt, I, Nilsen, TS, Krueger, RF, McGue, M, Pahlen, S, Corley, RP, Hjelmborg, JVB, Goldberg, JH, Iwatani, Y, Watanabe, M, Honda, C, Inui, F, Rasmussen, F, Huibregtse, BM, Boomsma, DI, Sorensen, TIA, Kaprio, J, and Silventoinen, K

Abstract

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

Published
2016

62. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Author

Jelenkovic, A, Sund, R, Hur, Y-M, Yokoyama, Y, Hjelmborg, JVB, Moller, S, Honda, C, Magnusson, PKE, Pedersen, NL, Ooki, S, Aaltonen, S, Stazi, MA, Fagnani, C, D'Ippolito, C, Freitas, DL, Maia, JA, Ji, F, Ning, F, Pang, Z, Rebato, E, Busjahn, A, Kandler, C, Saudino, KJ, Jang, KL, Cozen, W, Hwang, AE, Mack, TM, Gao, W, Yu, C, Li, L, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Heikkila, K, Wardle, J, Llewellyn, CH, Fisher, A, McAdams, TA, Eley, TC, Gregory, AM, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Eaves, LJ, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Bartels, M, van Beijsterveldt, TCEM, Craig, JM, Saffery, R, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Swan, GE, Krasnow, R, Tynelius, P, Lichtenstein, P, Haworth, CMA, Plomin, R, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Spector, T, Mangino, M, Lachance, G, Baker, LA, Tuvblad, C, Duncan, GE, Buchwald, D, Willemsen, G, Skytthe, A, Kyvik, KO, Christensen, K, Oncel, SY, Aliev, F, Rasmussen, F, Goldberg, JH, Sorensen, TIA, Boomsma, DI, Kaprio, J, Silventoinen, K, Jelenkovic, A, Sund, R, Hur, Y-M, Yokoyama, Y, Hjelmborg, JVB, Moller, S, Honda, C, Magnusson, PKE, Pedersen, NL, Ooki, S, Aaltonen, S, Stazi, MA, Fagnani, C, D'Ippolito, C, Freitas, DL, Maia, JA, Ji, F, Ning, F, Pang, Z, Rebato, E, Busjahn, A, Kandler, C, Saudino, KJ, Jang, KL, Cozen, W, Hwang, AE, Mack, TM, Gao, W, Yu, C, Li, L, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Heikkila, K, Wardle, J, Llewellyn, CH, Fisher, A, McAdams, TA, Eley, TC, Gregory, AM, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Eaves, LJ, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Bartels, M, van Beijsterveldt, TCEM, Craig, JM, Saffery, R, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Swan, GE, Krasnow, R, Tynelius, P, Lichtenstein, P, Haworth, CMA, Plomin, R, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Spector, T, Mangino, M, Lachance, G, Baker, LA, Tuvblad, C, Duncan, GE, Buchwald, D, Willemsen, G, Skytthe, A, Kyvik, KO, Christensen, K, Oncel, SY, Aliev, F, Rasmussen, F, Goldberg, JH, Sorensen, TIA, Boomsma, DI, Kaprio, J, and Silventoinen, K

Abstract

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Published
2016

64. Erfahrungen in der Behandlung von chirurgischen Patienten mit extrakorporalen Lungen- und Kreislaufunterstützungsverfahren (v.v.-ECMO, pECLA, v.a.-ECMO)

Author

Swol, J, Buchwald, D, Seybold, D, Strauch, J, and Schildhauer, T

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Polytrauma, Aspiration, Pneumonie oder fulminante Sepsis können zu einem schweren Lungenversagen und ARDS führen. Wenn der Gasaustausch nur noch durch eine aggressive Beatmung sichergestellt werden kann, verschlechtert sich die Prognose durch die beatmungsinduzierte Lungenschädigung.[for full text, please go to the a.m. URL], 131. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2014
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67. The CODATwins Project: the cohort description of collaborative project of development of anthropometrical measures in twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits

Author

Silventoinen, K., Jelenkovic, A., Sund, R., Honda, C., Aaltonen, S., Yokoyama, Y., Tarnoki, AD, Tarnoki, D. L., Ning, F., Ji, F., Pang, Z., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A., Eley, T. C., Gregory, A. M., Saudino, K. J., Dubois, L., Boivin, M., Haworth, C. M. A., Plomin, R., Öncel, S. Y., Aliev, F., Stazi, M. A., Fagnani, C., D'Ippolito, C., Craig, J., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Bayasgalan, G., Narandalai, D., Freitas, D. L., Maia, J. A., Harden, K. P., Tucker-Drob, E. M., Christensen, K., Skytthe, A., Kyvik, K. O., Hong, C., Chong, Y., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Chang, B., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Aujard, K., Magnusson, P. K. E., Pedersen, N. L., Aslan, A. K. D., Song, Y.- M., Yang, S., Lee, K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Heikkilä, K., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Inui, F., Watanabe, M., Bartels, M., van Beijsterveldt, T. C. E. M., Wardle, J., Llewellyn, C. H., Fisher, A., Rebato, E., Martin, N. G., Iwatani, Y., Hayakawa, K., Rasmussen, F., Sung, J., Harris, J. R., Willemsen, G., Busjahn, A., Goldberg, J. H., Boomsma, D. I., Hur, Y. - M., Sørensen, T. I. A., Kaprio, J., Silventoinen, K., Jelenkovic, A., Sund, R., Honda, C., Aaltonen, S., Yokoyama, Y., Tarnoki, AD, Tarnoki, D. L., Ning, F., Ji, F., Pang, Z., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A., Eley, T. C., Gregory, A. M., Saudino, K. J., Dubois, L., Boivin, M., Haworth, C. M. A., Plomin, R., Öncel, S. Y., Aliev, F., Stazi, M. A., Fagnani, C., D'Ippolito, C., Craig, J., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Bayasgalan, G., Narandalai, D., Freitas, D. L., Maia, J. A., Harden, K. P., Tucker-Drob, E. M., Christensen, K., Skytthe, A., Kyvik, K. O., Hong, C., Chong, Y., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Chang, B., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Aujard, K., Magnusson, P. K. E., Pedersen, N. L., Aslan, A. K. D., Song, Y.- M., Yang, S., Lee, K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Heikkilä, K., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Inui, F., Watanabe, M., Bartels, M., van Beijsterveldt, T. C. E. M., Wardle, J., Llewellyn, C. H., Fisher, A., Rebato, E., Martin, N. G., Iwatani, Y., Hayakawa, K., Rasmussen, F., Sung, J., Harris, J. R., Willemsen, G., Busjahn, A., Goldberg, J. H., Boomsma, D. I., Hur, Y. - M., Sørensen, T. I. A., and Kaprio, J.

Published
2015

69. Are chronic fatigue and chronic fatigue syndrome valid clinical entities across countries and health-care settings?

Author

Hickie, I., Davenport, T., Vernon, S.D., Nisenbaum, R., Reeves, W.C., Hadzi-Pavlovic, D., Lloyd, A., Bleijenberg, G., Werf, S.P. van der, Prins, J.B., Blenkiron, P.M., Buchwald, D., Smith, W.R., Edwards, R., Lynch, S., Kirmayer, L.J., Taillefer, S.S., Lee, S., Martin, N.G., Gillespie, N.E., McIlvenny, S., Sartorius, N., Ustun, T.B., Skapinakis, P., Wessely, S., Chalder, T., Hotopf, M., Nimnuan, C., Candy, B., Darbishire, L., Ridsdale, L., White, P.D., Thomas, J.M., Wilhelm, K., and Wilson, A.

Subjects
Adult, Cross-Cultural Comparison, Male, medicine.medical_specialty, Age-related aspects of cancer [ONCOL 2], Adolescent, Referral, Population, Neuropsychological Tests, Quality of Care [ONCOL 4], Young Adult, Epidemiology, Health care, medicine, Chronic fatigue syndrome, Humans, education, Aged, Aged, 80 and over, Neurologic Examination, education.field_of_study, Fatigue Syndrome, Chronic, Hereditary cancer and cancer-related syndromes [ONCOL 1], business.industry, Data Collection, Construct validity, Chronic fatigue, General Medicine, Psychological determinants of chronic illness [NCEBP 8], Middle Aged, medicine.disease, Psychiatry and Mental health, Cross-Sectional Studies, Clinical research, Physical therapy, Female, business
Abstract

Contains fulltext : 80178.pdf (Publisher’s version ) (Closed access) OBJECTIVE: The validity of the diagnosis of chronic fatigue syndrome and related chronic fatigue states remains controversial, particularly in psychiatry. This project utilized international epidemiological and clinical research data to test construct validity across diagnostic categories, health-care settings and countries. Relevant demographic, symptom and diagnostic data were obtained from 33 studies in 21 countries. The subjects had fatigue lasting 1-6 months (prolonged fatigue), or >6 months (chronic fatigue), or met diagnostic criteria for chronic fatigue syndrome. METHOD: Common symptom domains were derived by factor analytic techniques. Mean scores on each symptom factor were compared across diagnostic categories, health-care settings and countries. RESULTS: Data were obtained on 37,724 subjects (n = 20,845 female, 57%), including from population-based studies (n = 15,749, 42%), studies in primary care (n = 19 472, 52%), and secondary or specialist tertiary referral clinics (n = 2503, 7%). The sample included 2013 subjects with chronic fatigue, and 1958 with chronic fatigue syndrome. A five-factor model of the key symptom domains was preferred ('musculoskeletal pain/fatigue', 'neurocognitive difficulties', 'inflammation', 'sleep disturbance/fatigue' and 'mood disturbance') and was comparable across subject groups and settings. Although the core symptom profiles were similar, some differences in symptoms were observed across diagnostic categories, health-care settings and between countries. CONCLUSIONS: The construct validity of chronic fatigue and chronic fatigue syndrome is supported by an empirically derived factor structure from existing international datasets.

Published
2009

70. The collected papers of Albert Einstein. - Vol. 11: Cumulative index, bibliography, list of correspondence, chronology, and errata to volumes 1-10

Author

Kox, A.J., Sauer, T., Kormos Buchwald, D., Hirschmann, R., Moses, O., Aronin, B., Stolper, J., and History of Physics (ITFA, IoP, FNWI)

Abstract

This index volume provides quick access to the most authoritative compilation of documents and information concerning Einstein's work and correspondence for the first half of his life. It offers readers a Cumulative Index to the first ten volumes of the collected papers, the first complete bibliography of Einstein's scientific and nonscientific writings until 1921, and a succinct biographical time line. This volume is a research tool for delving into Einstein's written legacy; his interactions with colleagues, institutions, friends, and family; and his scientific, political, educational, and social activities. Volume 11 presents three important and unique bibliographies: the List of Writings, 1891-1921; the Einstein Bibliography, 1901-1921; and a Cumulative Bibliography and Index of Citations for Volumes 1-10. The List of Writings includes all of Einstein's manuscripts that remained unpublished by 1921, while the Einstein Bibliography includes documents that were republished during this period. The Cumulative Bibliography and Index of Citations lists all literature written by authors cited in at least one of the first ten volumes of the series. This volume also contains two complete lists of Einstein's correspondence up through 1920, and a Chronology of Einstein's life for the years 1879-1921. The first list presents the correspondence in chronological order, while the second list presents the correspondence in alphabetical order by correspondent. The indexes and bibliographies implicitly correct inconsistencies and errata across the different volumes. Other corrections are explicitly collected in a List of Errata for the first ten volumes of the series.

Published
2009

71. Behandlung des Lungenversagens beim Polytrauma – Einsatz von extrakorporalen Lungenersatzverfahren (iLA Membranventilator) und Hochfrequenz Beatmung (HFOV)

Author

Swol, J, Schinkel, C, Schildhauer, TA, Buchwald, D, and Muhr, G

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Ein Polytrauma (ISS > 18) geht sehr häufig (bis zu 80%) mit einem schweren Thoraxtrauma einher. Diese Patienten sind gefährdet, ein akutes posttraumatisches Lungenversagen zu entwickeln. Nach Abklingen des Systemic Inflammatory Response Syndrome (SIRS) kann es zu einer[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009
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75. En alternativ vej

Author

Buchwald, D., Svenningsen, L.M., and Svendsen, L.N.

Published
2005

78. Writings 1918-1921

Author

Kox, A.J., Janssen, M, Schulmann, R, Illy, J, Lehner, C, Kormos Buchwald, D, Kox, A.J, and History of Physics (ITFA, IoP, FNWI)

Published
2002

81. Fatigue: case definition and guidelines for collection, analysis, and presentation of immunization safety data.

Author

Jones, J.F., Kohl, K.S., Ahmadipour, N., Bleijenberg, G., Buchwald, D., Evengard, B., Jason, L.A., Klimas, N.G., Lloyd, A., McCleary, K., Oleske, J.M., White, P.D., Jones, J.F., Kohl, K.S., Ahmadipour, N., Bleijenberg, G., Buchwald, D., Evengard, B., Jason, L.A., Klimas, N.G., Lloyd, A., McCleary, K., Oleske, J.M., and White, P.D.

Abstract

Contains fulltext : 52164.pdf (publisher's version ) (Closed access)

Published
2007

82. A review of the evidence for overlap among unexplained clinical conditions.

Author

Aaron LA, Buchwald D, Aaron, L A, and Buchwald, D

Abstract

Purpose: Unexplained clinical conditions share features, including symptoms (fatigue, pain), disability out of proportion to physical examination findings, inconsistent demonstration of laboratory abnormalities, and an association with "stress" and psychosocial factors. This literature review examines the nature and extent of the overlap among these unexplained clinical conditions and the limitations of previous research.Data Sources: English-language articles were identified by a search of the MEDLINE database from 1966 to January 2001 by using individual syndromes and their hallmark symptoms as search terms.Study Selection: Studies that assessed patients with at least one unexplained clinical condition and that included information on symptoms, overlap with other unexplained clinical conditions, or physiologic markers. Conditions examined were the chronic fatigue syndrome, fibromyalgia, the irritable bowel syndrome, multiple chemical sensitivity, temporomandibular disorder, tension headache, interstitial cystitis, and the postconcussion syndrome.Data Extraction: Information on authorship, patient and control groups, eligibility criteria, case definitions, study methods, and major findings.Data Synthesis: Many similarities were apparent in case definition and symptoms, and the proportion of patients with one unexplained clinical condition meeting criteria for a second unexplained condition was striking. Tender points on physical examination and decreased pain threshold and tolerance were the most frequent and consistent objective findings. A major shortcoming of all proposed explanatory models is their inability to account for the occurrence of unexplained clinical conditions in many affected patients.Conclusions: Overlap between unexplained clinical conditions is substantial. Most studies are limited by methodologic problems, such as case definition and the selection and recruitment of case-patients and controls. [ABSTRACT FROM AUTHOR]

Published
2001
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83. Multimodal Viscum album L. treatment in an integrative oncological setting in patients with advanced pancreatic carcinoma

Author

Schad, F., Buchwald, D., Merkle, A., Popp, S., Krdz, M., and Matthes, H.

Subjects
Care and treatment, Research, Health aspects, Oncology -- Research, Pancreatic cancer -- Care and treatment, Carcinoma -- Care and treatment, Mistletoes -- Health aspects, Integrative medicine -- Research, Cancer -- Care and treatment, Mistletoe -- Health aspects
Abstract

Background: Integrative therapy concepts are of growing interest in oncology. Viscum album L. (VAL) has become a widely used concurrent option in cancer treatment. Patients with advanced pancreatic carcinoma (80% [...]

Published
2011
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84. Mistletoe therapy in adjuvant and palliative therapy of pancreatic carcinoma: concepts-facts-perspectives

Author

Matthes, H., Buchwald, D., and Schad, F.

Subjects
Management, Care and treatment, Health aspects, Company business management, Palliative care -- Management, Pancreatic cancer -- Care and treatment, Adjuvant chemotherapy -- Management, Mistletoes -- Health aspects, Cancer -- Adjuvant treatment, Palliative treatment -- Management, Mistletoe -- Health aspects
Abstract

Introduction: Pancreatic adenocarcinoma (PCa) is still a diagnostic and therapeutic challenge. Less than 10% of PCa are curable with RO-resection at time of diagnosis, 5-year survival rate is < l%, [...]

Published
2011
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88. Evaluation of cerebrospinal fluid in Southeast Asian refugees with reactive serologic tests for syphilis

Author

Buchwald, D, Collier, A C, Lukehart, S A, Kith, P, Goldstein, E, and Hooton, T M

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Cerebrospinal Fluid Proteins, Middle Aged, Syphilis Serodiagnosis, Leukocyte Count, Neurosyphilis, Yaws, Humans, Female, Prospective Studies, Syphilis, Asia, Southeastern, Research Article, Aged, Cerebrospinal Fluid, Retrospective Studies
Abstract

To determine the prevalence of cerebrospinal fluid abnormalities in Southeast Asian refugees with reactive serologic tests for syphilis, we evaluated 65 patients, 36 prospectively and 29 retrospectively, in a primary care clinic. Information was collected on history of treponemal infections, neurologic symptoms and signs, and total protein concentration, leukocyte count, and the VDRL test in the cerebrospinal fluid. Neurologic symptoms were reported by all patients for whom data were available. Abnormal neurologic signs were found or noted in medical records in 15 (42%) prospectively evaluated patients and 9 (64%) of 14 retrospectively evaluated patients for whom data were available. No patient had evidence of congenital or non-neurologic sequelae such as cutaneous or cardiovascular manifestations of syphilis. No patient had a positive cerebrospinal fluid VDRL test, 1 had more than 5 x 10(6) leukocytes per liter (5 leukocytes per mm3), and 6 (9%) had elevated total protein levels in the cerebrospinal fluid. Previous therapy for syphilis was not associated with lower serum VDRL reactions, neurologic symptoms and signs, or cerebrospinal fluid findings. In the absence of other indications, routine examination of the cerebrospinal fluid in seropositive Southeast Asian refugees who have nonspecific neurologic symptoms has a low yield, perhaps because of the high prevalence of yaws in this population, and may not be warranted.

Published
1996

89. Chronic fatigue syndrome in practice.

Author

Afari, N., Meer, J.W.M. van der, Bleijenberg, G., Buchwald, D., Afari, N., Meer, J.W.M. van der, Bleijenberg, G., and Buchwald, D.

Abstract

Item does not contain fulltext

Published
2005

91. Dr Baschetti rides/writes again

Author

Meer, J.W.M. van der, Lamberts, S.W.J., Buchwald, D., Meer, J.W.M. van der, Lamberts, S.W.J., and Buchwald, D.

Abstract

Contains fulltext : 13846.pdf (publisher's version ) (Closed access)

Published
2004

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