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51. Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes

Author

Rivera, Natalia V, Carreras-Torres, Robert, Roncarati, Roberta, Viviani-Anselmi, Chiara, De Micco, Francesca, Mezzelani, Alessandra, Koch, Werner, Hoppmann, Petra, Kastrati, Adnan, Stewart, Alexandre FR, Chen, Li, Roberts, Robert, Karssen, Lennart C, Amin, Najaf, Trimarco, Valentina, Izzo, Raffaele, Iaccarino, Guido, Condorelli, Gerolama, Puca, Annibale A, Pagnotta, Paolo, Airoldi, Flavio, Trimarco, Bruno, van Duijn, Cornelia M, Condorelli, Gianluigi, and Briguori, Carlo

Abstract

Abstract Background The 9p21.3 locus is strongly associated with the risk of coronary artery disease (CAD) and with type 2 diabetes (T2D). We investigated the association of 9p21.3 variants with severity of CAD (defined by the number of vessel diseased [VD]) in the presence and absence of T2D. Methods We tested 11 9p21.3-variants for association in a white Italian study (N = 2,908), and carried out replication in 2 independent white populations, a German study (N = 2,028) and a Canadian Study (N=950). SNP association and permutation analyses were conducted. Results We identified two 9p21.3-variants, rs4977574 (P < 4×10-4) and rs2383207 (P < 1.5×10-3) that were associated with severity of CAD in subjects without T2D. Association of rs4977574 with severity of CAD was confirmed in the Canadian Study. Results from subgroup analysis among patients with T2D showed an interaction between rs10738610 and T2D with P = 4.82×10-2. Further investigation showed that rs10738610 (P < 1.99×10-2) was found to be significantly associated with severity of CAD in subjects with T2D. Conclusions The 9p21.3 locus is significantly associated with severity of CAD. The number of associations of 9p21.3 variants with severity of CAD is variable to the presence and absence of T2D. In a CAD-susceptible region of 115 kb, there is only one variant associated with the severity of coronary vessel disease in the presence of type 2 diabetes.

Published
2013

52. Polymer-free amphilimus-eluting stent versus biodegradable polymer biolimus-eluting stent in patients with and without diabetes mellitus

Author

Godino, Cosmo, Pivato, Carlo Andrea, Chiarito, Mauro, Donahue, Michael, Testa, Luca, Colantonio, Riccardo, Cappelletti, Alberto, Milazzo, Diego, Parisi, Rosario, Nicolino, Annamaria, Moshiri, Shahram, Aprigliano, Gianfranco, Palloshi, Altin, Zavalloni Parenti, Dennis, Rutigliano, David, Locuratolo, Nicola, Melillo, Francesco, Scotti, Andrea, Arrigoni, Luca, Montorfano, Matteo, Fattori, Rossella, Presbitero, Patrizia, Sardella, Gennaro, Bedogni, Francesco, Margonato, Alberto, Briguori, Carlo, and Colombo, Antonio

Published
2017
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54. Impact of in-Hospital Left Ventricular Ejection Fraction Recovery on Long-Term Outcomes in Patients who Underwent Impella Support for HR PCI or Cardiogenic Shock: A Sub-Analysis from the IMP-IT Registry

Author

Iannaccone, Mario, primary, Franchin, Luca, additional, Burzotta, Francesco, additional, Botti, Giulia, additional, Pazzanese, Vittorio, additional, Briguori, Carlo, additional, Trani, Carlo, additional, Piva, Tommaso, additional, De Marco, Federico De, additional, Masiero, Giulia, additional, Di Biasi, Maurizio Di, additional, Pagnotta, Paolo, additional, Casu, Gavino, additional, Scandroglio, Anna Mara, additional, Tarantini, Giuseppe, additional, and Chieffo, Alaide, additional

Published
2023
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56. Midterm and one-year outcome of amphilimus polymer free drug eluting stent in patients needing short dual antiplatelet therapy. Insight from the ASTUTE registry (AmphilimuS iTalian mUlticenTer rEgistry)

Author

Godino, Cosmo, Chiarito, Mauro, Donahue, Michael, Testa, Luca, Colantonio, Riccardo, Cappelletti, Alberto, Monello, Alberto, Magni, Valeria, Milazzo, Diego, Parisi, Rosario, Nicolino, Annamaria, Moshiri, Shahram, Fattori, Rossella, Aprigliano, Gianfranco, Palloshi, Altin, Caramanno, Giuseppe, Montorfano, Matteo, Bedogni, Francesco, Briguori, Carlo, Margonato, Alberto, and Colombo, Antonio

Published
2017
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59. Population Trends in Rates of Percutaneous Coronary Revascularization for Acute Coronary Syndromes Associated With the COVID-19 Outbreak

Author

Piccolo, Raffaele, Bruzzese, Dario, Mauro, Ciro, Aloia, Antonio, Baldi, Cesare, Boccalatte, Marco, Bottiglieri, Giuseppe, Briguori, Carlo, Caiazzo, Gianluca, Calabrò, Paolo, Cappelli-Bigazzi, Maurizio, De Simone, Ciro, Di Lorenzo, Emilio, Golino, Paolo, Monda, Vittorio, Perrotta, Rocco, Quaranta, Gaetano, Russolillo, Enrico, Scherillo, Marino, Tesorio, Tullio, Tuccillo, Bernardino, Valva, Giuseppe, Villari, Bruno, Tarantini, Giuseppe, Varricchio, Attilio, and Esposito, Giovanni

Published
2020
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62. Outcome of nonobstructive residual dissections detected by intravascular ultrasound following percutaneous coronary intervention

Author

Nishida, Takahiro, Colombo, Antonio, Briguori, Carlo, Stankovic, Goran, Albiero, Remo, Corvaja, Nicola, Finci, Leo, Di Mario, Carlo, and Tobis, Jonathan M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Bioengineering, Heart Disease - Coronary Heart Disease, Cardiovascular, Atherosclerosis, Heart Disease, Aortic Dissection, Angioplasty, Balloon, Coronary, Coronary Angiography, Coronary Disease, Coronary Restenosis, Coronary Vessels, Humans, Myocardial Infarction, Retrospective Studies, Stents, Treatment Outcome, Ultrasonography, Interventional, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

The purpose of this study was to assess the outcome of nonobstructive (or non-flow-limiting) residual dissection (RD) after percutaneous coronary intervention. Results of 124 consecutive native coronary lesions with angiographic nonobstructive RD in 97 patients (RD group) were compared with outcomes of 124 lesions without RD in 100 patients (non-RD group), whose characteristics were matched with those of the RD group. RD occurred after stent implantation (81 of 124 lesions, 65%) or balloon angioplasty (43 of 124 lesions, 35%). Angiographic types of RD were type A in 8 lesions (6%), B in 101 (82%), and C in 15 (12%). Stents were implanted in 65% of the lesions in each group. Clinical success (94% in RD group vs 95% in non-RD group, p = 0.77) and the in-hospital major adverse cardiac event rates were found to be similar in the 2 groups (6% vs 3%, respectively; p = 0.33). The late angiographic and clinical outcomes were also comparable. By intravascular ultrasound (IVUS) evaluation of the dissections in the RD group, area stenosis correlated with the incidence of in-hospital major adverse cardiac events (p = 0.023), whereas the final minimal lumen area correlated inversely with the occurrence of restenosis (p = 0.011). An area stenosis > or =58% was the best predictor for the incidence of in-hospital major adverse cardiac events (sensitivity 0.68, specificity 0.68). Most nonobstructive RDs are "favorable" and do not need stent implantation. IVUS evaluation identifies "unfavorable" nonobstructive (or non-flow-limiting) dissections that might be prone to acute occlusion. Nonobstructive dissections can be left untreated when final IVUS reveals an area stenosis of < 60% at the site of a dissection.

Published
2002

63. Cutting balloon to optimize predilation for stent implantation: The COPS randomized trial

Author

Mangieri, Antonio, primary, Nerla, Roberto, additional, Castriota, Fausto, additional, Reimers, Bernhard, additional, Regazzoli, Damiano, additional, Leone, Pier P., additional, Gasparini, Gabriele L., additional, Khokhar, Arif A., additional, Laricchia, Alessandra, additional, Giannini, Francesco, additional, Casale, Fulvio, additional, Bezzeccheri, Andrea, additional, Briguori, Carlo, additional, and Colombo, Antonio, additional

Published
2023
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64. CRT-600.1 Reproducibility of an Artificial Intelligence Optical Coherence Tomography Software for Tissue Characterization: Implications for the Design of Longitudinal Studies

Author

Garg, Mohil, primary, Garcia-Garcia, Hector M., additional, Calderón, Andrea Teira, additional, Gupta, Jaytin, additional, Sortur, Shrayus, additional, Levine, Molly B., additional, Picchi, Andrea, additional, Sardella, Gennaro, additional, Adamo, Marianna, additional, Frigoli, Enrico, additional, Limbruno, Ugo, additional, Rigattieri, Stefano, additional, Diletti, Roberto, additional, Boccuzzi, Giacomo, additional, Zimarino, Marco, additional, Contarini, Marco, additional, Russo, Filippo, additional, Calabro, Paolo, additional, Andò, Giuseppe, additional, Varbella, Ferdinando, additional, Garducci, Stefano, additional, Palmieri, Cataldo, additional, Briguori, Carlo, additional, Sánchez, Jorge Sanz, additional, and Valgimigli, Marco, additional

Published
2023
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65. Ticagrelor with or without aspirin in high-risk patients with anaemia undergoing percutaneous coronary intervention: a subgroup analysis of the TWILIGHT trial

Author

Spirito, Alessandro, primary, Kastrati, Adnan, additional, Cao, Davide, additional, Baber, Usman, additional, Sartori, Samantha, additional, Angiolillo, Dominick J, additional, Briguori, Carlo, additional, Cohen, David J, additional, Dangas, George, additional, Dudek, Dariusz, additional, Escaned, Javier, additional, Gibson, C Michael, additional, Zhang, Zhongjie, additional, Huber, Kurt, additional, Kaul, Upendra, additional, Kornowski, Ran, additional, Kunadian, Vijay, additional, Han, Ya-Ling, additional, Mehta, Shamir R, additional, Sardella, Gennaro, additional, Sharma, Samin, additional, Shlofmitz, Richard A, additional, Vogel, Birgit, additional, Collier, Timothy, additional, Pocock, Stuart, additional, and Mehran, Roxana, additional

Published
2023
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66. Survival After Invasive or Conservative Management of Stable Coronary Disease

Author

Hochman, Judith S., primary, Anthopolos, Rebecca, additional, Reynolds, Harmony R., additional, Bangalore, Sripal, additional, Xu, Yifan, additional, O’Brien, Sean M., additional, Mavromichalis, Stavroula, additional, Chang, Michelle, additional, Contreras, Aira, additional, Rosenberg, Yves, additional, Kirby, Ruth, additional, Bhargava, Balram, additional, Senior, Roxy, additional, Banfield, Ann, additional, Goodman, Shaun G., additional, Lopes, Renato D., additional, Pracoń, Radosław, additional, López-Sendón, José, additional, Maggioni, Aldo Pietro, additional, Newman, Jonathan D., additional, Berger, Jeffrey S., additional, Sidhu, Mandeep S., additional, White, Harvey D., additional, Troxel, Andrea B., additional, Harrington, Robert A., additional, Boden, William E., additional, Stone, Gregg W., additional, Mark, Daniel B., additional, Spertus, John A., additional, Maron, David J., additional, Hochman, Judith S., additional, Esquenazi-Karonika, Shari, additional, Gilsenan, Margaret, additional, Gwiszcz, Ewelina, additional, Mathews, Patenne, additional, Mohamed, Samaa, additional, Naumova, Anna, additional, Roberts, Arline, additional, VanLoo, Kerrie, additional, Lu, Ying, additional, Huang, Zhen, additional, Broderick, Samuel, additional, Guzmán, Luis, additional, Selvanayagam, Joseph, additional, Steg, Gabriel, additional, Juliard, Jean-Michel, additional, Doerr, Rolf, additional, Keltai, Matyas, additional, Thomas, Boban, additional, Sharir, Tali, additional, Nikolsky, Eugenia, additional, Maggioni, Aldo P., additional, Kohsaka, Shun, additional, Escobedo, Jorge, additional, Bockeria, Olga, additional, Held, Claes, additional, Shaw, Leslee J., additional, Phillips, Lawrence, additional, Berman, Daniel, additional, Kwong, Raymond Y., additional, Picard, Michael H., additional, Chaitman, Bernard R., additional, Ali, Ziad, additional, Min, James, additional, Mancini, G.B. John, additional, Leipsic, Jonathon, additional, Hillis, Graham, additional, Thambar, Suku, additional, Joseph, Majo, additional, Beltrame, John, additional, Lang, Irene, additional, Schuchlenz, Herwig, additional, Huber, Kurt, additional, Goetschalckx, Kaatje, additional, Hueb, Whady, additional, Caramori, Paulo Ricardo, additional, de Quadros, Alexandre, additional, Smanio, Paola, additional, Mesquita, Claudio, additional, Vitola, João, additional, Marin-Neto, José, additional, da Silva, Expedito Ribeiro, additional, Tumelero, Rogério, additional, Andrade, Marianna, additional, Alves, Alvaro Rabelo, additional, Dall’Orto, Frederico, additional, Polanczyk, Carisi, additional, Figueiredo, Estevão, additional, Howarth, Andrew, additional, Gosselin, Gilbert, additional, Cheema, Asim, additional, Bainey, Kevin, additional, Phaneuf, Denis, additional, Diaz, Ariel, additional, Garg, Pallav, additional, Mehta, Shamir, additional, Wong, Graham, additional, Lam, Andy, additional, Cha, James, additional, Galiwango, Paul, additional, Uxa, Amar, additional, Chow, Benjamin (Ben), additional, Hameed, Adnan, additional, Udell, Jacob, additional, Hamid, Magdy, additional, Hauguel-Moreau, Marie, additional, Furber, Alain, additional, Goube, Pascal, additional, Steg, Philippe-Gabriel, additional, Barone-Rochette, Gilles, additional, Thuaire, Christophe, additional, Slama, Michel, additional, Nickenig, Georg, additional, Bekeredjian, Raffi, additional, Schulze, P. Christian, additional, Merkely, Bela, additional, Fontos, Geza, additional, Vértes, András, additional, Varga, Albert, additional, Kumar, Ajit, additional, Nair, Rajesh G., additional, Grant, Purvez, additional, Manjunath, Cholenahally, additional, Moorthy, Nagaraja, additional, Satheesh, Santhosh, additional, Nath, Ranjit Kumar, additional, Wander, Gurpreet, additional, Christopher, Johann, additional, Dwivedi, Sudhanshu, additional, Oomman, Abraham, additional, Mathur, Atul, additional, Gadkari, Milind, additional, Naik, Sudhir, additional, Punnoose, Eapen, additional, Kachru, Ranjan, additional, Kaul, Upendra, additional, Kerner, Arthur, additional, Tarantini, Giuseppe, additional, Perna, Gian Piero, additional, Racca, Emanuela, additional, Mortara, Andrea, additional, Monti, Lorenzo, additional, Briguori, Carlo, additional, Leone, Gianpiero, additional, Amati, Roberto, additional, Salvatori, Mauro, additional, Di Chiara, Antonio, additional, Calabro, Paolo, additional, Galvani, Marcello, additional, Provasoli, Stefano, additional, Fukuda, Keiichi, additional, Nakano, Shintaro, additional, Laucevicius, Aleksandras, additional, Kedev, Sasko, additional, Khairuddin, Ahmad, additional, Riezebos, Robert, additional, Timmer, Jorik, additional, Heald, Spencer, additional, Stewart, Ralph, additional, Ramos, Walter Mogrovejo, additional, Demkow, Marcin, additional, Mazurek, Tomasz, additional, Drozdz, Jarozlaw, additional, Szwed, Hanna, additional, Witkowski, Adam, additional, Ferreira, Nuno, additional, Pinto, Fausto, additional, Ramos, Ruben, additional, Popescu, Bogdan, additional, Pop, Calin, additional, Bockeria, Leo, additional, Demchenko, Elena, additional, Romanov, Alexander, additional, Bershtein, Leonid, additional, Jizeeri, Ahmed, additional, Stankovic, Goran, additional, Apostolovic, Svetlana, additional, Adjic, Nada Cemerlic, additional, Zdravkovic, Marija, additional, Beleslin, Branko, additional, Dekleva, Milica, additional, Davidovic, Goran, additional, Chua, Terrance, additional, Foo, David, additional, Poh, Kian Keong, additional, Ntsekhe, Mpiko, additional, Sionis, Alessandro, additional, Marin, Francisco, additional, Miró, Vicente, additional, Blancas, Montserrat Gracida, additional, González-Juanatey, José, additional, Fernández-Avilés, Francisco, additional, Peteiro, Jesús, additional, Luena, Jose Enrique Castillo, additional, Aspberg, Johannes, additional, Rossi, Mariagrazia, additional, Kuanprasert, Srun, additional, Yamwong, Sukit, additional, Johnston, Nicola, additional, Donnelly, Patrick, additional, Moriarty, Andrew, additional, Elghamaz, Ahmed, additional, Gurunathan, Sothinathan, additional, Karogiannis, Nikolaos, additional, Shah, Benoy N., additional, Trimlett, Richard H.J., additional, Rubens, Michael B., additional, Nicol, Edward D., additional, Mittal, Tarun K., additional, Hampson, Reinette, additional, Gamma, Reto, additional, De Belder, Mark, additional, Nageh, Thuraia, additional, Lindsay, Steven, additional, Mavromatis, Kreton, additional, Miller, Todd, additional, Banerjee, Subhash, additional, Reynolds, Harmony, additional, Nour, Khaled, additional, and Stone, Peter, additional

Published
2023
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67. Cause-Specific Mortality in Patients With Advanced Chronic Kidney Disease in the ISCHEMIA-CKD Trial

Author

Sidhu, Mandeep S., primary, Alexander, Karen P., additional, Huang, Zhen, additional, Mathew, Roy O., additional, Newman, Jonathan D., additional, O’Brien, Sean M., additional, Pellikka, Patricia A., additional, Lyubarova, Radmila, additional, Bockeria, Olga, additional, Briguori, Carlo, additional, Kretov, Evgeny L., additional, Mazurek, Tomasz, additional, Orso, Francesco, additional, Roik, Marek F., additional, Sajeev, Chakkanalil, additional, Shutov, Evgeny V., additional, Rockhold, Frank W., additional, Borrego, David, additional, Balter, Stephen, additional, Stone, Gregg W., additional, Chaitman, Bernard R., additional, Goodman, Shaun G., additional, Fleg, Jerome L., additional, Reynolds, Harmony R., additional, Maron, David J., additional, Hochman, Judith S., additional, and Bangalore, Sripal, additional

Published
2023
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69. Transient vs In-Hospital Persistent Acute Kidney Injury in Patients With Acute Coronary Syndrome

Author

Landi, Antonio, primary, Branca, Mattia, additional, Leonardi, Sergio, additional, Frigoli, Enrico, additional, Vranckx, Pascal, additional, Tebaldi, Matteo, additional, Varbella, Ferdinando, additional, Calabró, Paolo, additional, Esposito, Giovanni, additional, Sardella, Gennaro, additional, Garducci, Stefano, additional, Andò, Giuseppe, additional, Limbruno, Ugo, additional, Sganzerla, Paolo, additional, Santarelli, Andrea, additional, Briguori, Carlo, additional, Colangelo, Salvatore, additional, Brugaletta, Salvatore, additional, Adamo, Marianna, additional, Omerovic, Elmir, additional, Heg, Dik, additional, Windecker, Stephan, additional, and Valgimigli, Marco, additional

Published
2023
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70. One-year clinical outcome of amphilimus polymer-free drug-eluting stent in diabetes mellitus patients: Insight from the ASTUTE registry (AmphilimuS iTalian mUlticenTre rEgistry)

Author

Colombo, Antonio, Godino, Cosmo, Donahue, Michael, Testa, Luca, Chiarito, Mauro, Pavon, Anna Giulia, Colantonio, Riccardo, Cappelletti, Alberto, Monello, Alberto, Magni, Valeria, Milazzo, Diego, Parisi, Rosario, Nicolino, Annamaria, Moshiri, Shahram, Fattori, Rossella, Aprigliano, Gianfranco, Palloshi, Altin, Caramanno, Giuseppe, Montorfano, Matteo, Bedogni, Francesco, Margonato, Alberto, and Briguori, Carlo

Published
2016
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71. Is Bare-Metal Stent Implantation Still Justifiable in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention?: A Pre-Specified Analysis From the ZEUS Trial

Author

Ariotti, Sara, Adamo, Marianna, Costa, Francesco, Patialiakas, Athanasios, Briguori, Carlo, Thury, Attila, Colangelo, Salvatore, Campo, Gianluca, Tebaldi, Matteo, Ungi, Imre, Tondi, Stefano, Roffi, Marco, Menozzi, Alberto, de Cesare, Nicoletta, Garbo, Roberto, Meliga, Emanuele, Testa, Luca, Gabriel, Henrique Mesquita, Ferlini, Marco, Vranckx, Pascal, and Valgimigli, Marco

Published
2016
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72. Bifurcation lesions: two stents versus one stent—immediate and follow-up results

Author

Yamashita, Takehiro, Nishida, Takahiro, Adamian, Milena G, Briguori, Carlo, Vaghetti, Marco, Corvaja, Nicola, Albiero, Remo, Finci, Leo, Di Mario, Carlo, Tobis, Jonathan M, and Colombo, Antonio

Subjects
Bioengineering, Atherosclerosis, Assistive Technology, Cardiovascular, Aged, Angioplasty, Balloon, Coronary, Coronary Angiography, Coronary Disease, Female, Follow-Up Studies, Hospital Mortality, Humans, Incidence, Male, Middle Aged, Recurrence, Risk Factors, Severity of Illness Index, Stents, Treatment Outcome, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

ObjectivesThe purpose of this study was to evaluate two different techniques of stent placement in bifurcation lesions.BackgroundAlthough stent placement with dedicated techniques has been suggested to be a useful therapeutic modality for bifurcation lesions, limited information is available if stent placement on the side branch and on the parent branch provides any advantage over a simpler strategy of stenting the parent vessel and balloon angioplasty of the side branch.MethodsBetween March 1993 and April 1999, we treated a total of 92 patients with bifurcation lesions with two strategies: stenting both vessels (group B, n = 53) or stenting the parent vessel and balloon angioplasty of the side branch (group P, n = 39). Paired angiograms were analyzed by quantitative angiography, and clinical follow-up was obtained.ResultsStent placement on both branches resulted in a lower residual stenosis (7.4 +/- 10.9% vs. 23.4% +/- 18.7%, p < 0.001) in the side branch. Acute procedural success was similar in the two groups (group B: 87% vs. Group P: 92%). In-hospital major adverse cardiac events (MACE) occurred only in group B (13% vs. 0%, p < 0.05). At the six-month follow-up, the angiographic restenosis rate (group B: 62% vs. Group P: 48%) and the target lesion revascularization rate (38% vs. 36%, respectively) were similar in the two groups. There was no difference in the incidence of six-month total MACE (51% vs. 38%).ConclusionsFor the treatment of true bifurcation lesions, a complex strategy of stenting both vessels provided no advantage in terms of procedural success and late outcome versus a simpler strategy of stenting only the parent vessel.

Published
2000

73. Reproducibility of an artificial intelligence optical coherence tomography software for tissue characterization: Implications for the design of longitudinal studies

Author

Garg, Mohil, Garcia-Garcia, Hector M, Calderón, Andrea Teira, Gupta, Jaytin, Sortur, Shrayus, Levine, Molly B, Singla, Puneet, Picchi, Andrea, Sardella, Gennaro, Adamo, Marianna, Frigoli, Enrico, Limbruno, Ugo, Rigattieri, Stefano, Diletti, Roberto, Boccuzzi, Giacomo, Zimarino, Marco, Contarini, Marco, Russo, Filippo, Calabro, Paolo, Andò, Giuseppe, Varbella, Ferdinando, Garducci, Stefano, Palmieri, Cataldo, Briguori, Carlo, Sánchez, Jorge Sanz, and Valgimigli, Marco

Subjects
610 Medicine & health
Abstract

BACKGROUND To assess the reproducibility of coronary tissue characterization by an Artificial Intelligence Optical Coherence Tomography software (OctPlus, Shanghai Pulse Medical Imaging Technology Inc.). METHODS 74 patients presenting with multivessel ST-segment elevation myocardial infarction (STEMI) underwent optical coherence tomography (OCT) of the infarct-related artery at the end of primary percutaneous coronary intervention (PPCI) and during staged PCI (SPCI) within 7 days thereafter in the MATRIX (Minimizing Adverse Hemorrhagic Events by Transradial Access Site and angioX) Treatment-Duration study (ClinicalTrials.gov, NCT01433627). OCT films were run through the OctPlus software. The same region of interest between either side of the stent and the first branch was identified on OCT films for each patient at PPCI and SPCI, thus generating 94 pairs of segments. 42 pairs of segments were re-analyzed for intra-software difference. Five plaque characteristics including cholesterol crystal, fibrous tissue, calcium, lipid, and macrophage content were analyzed for various parameters (span angle, thickness, and area). RESULTS There was no statistically significant inter-catheter (between PPCI and SPCI) or intra-software difference in the mean values of all the parameters. Inter-catheter correlation for area was best seen for calcification [intraclass correlation coefficient (ICC) 0.86], followed by fibrous tissue (ICC 0.87), lipid (ICC 0.62), and macrophage (ICC 0.43). Some of the inter-catheter relative differences for area measurements were large: calcification 9.75 %; cholesterol crystal 74.10 %; fibrous tissue 5.90 %; lipid 4.66 %; and macrophage 1.23 %. By the intra-software measurements, there was an excellent correlation (ICC > 0.9) for all tissue types. The relative differences for area measurements were: calcification 0.64 %; cholesterol crystal 5.34 %; fibrous tissue 0.19 %; lipid 1.07 %; and macrophage 0.60 %. Features of vulnerable plaque, minimum fibrous cap thickness and lipid area showed acceptable reproducibility. CONCLUSION The present study demonstrates an overall good reproducibility of tissue characterization by the Artificial Intelligence Optical Coherence Tomography software. In future longitudinal studies, investigators may use discretion in selecting the imaging endpoints and sample size, accounting for the observed relative differences in this study.

Published
2023
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75. Safety and efficacy of ticagrelor monotherapy according to drug-eluting stent type: the TWILIGHT-STENT study

Author

Dangas, George, Baber, Usman, Sharma, Samin, Giustino, Gennaro, Sartori, Samantha, Nicolas, Johny, Goel, Ridhima, Mehta, Shamir, Cohen, David J., Angiolillo, Dominick J., Zhang, Zhongjie, Camaj, Anton, Cao, Davide, Briguori, Carlo, Dudek, Dariusz, Escaned, Javier, Huber, Kurt, Collier, Timothy, Kornowski, Ran, Kunadian, Vijay, Moliterno, David J., Ohman, E. Magnus, Weisz, Giora, Gil, Robert, Krucoff, Mitchell W., Kaul, Upendra, Oldroyd, Keith G., Sardella, Gennaro, Shlofmitz, Richard, Witzenbichler, Bernhard, Kastrati, Adnan, Han, Ya-ling, Steg, Philippe Gabriel, Pocock, Stuart, Gibson, C. Michael, and Mehran, Roxana

Subjects
Ticagrelor, Percutaneous Coronary Intervention, Treatment Outcome, Clinical Research, Humans, Drug-Eluting Stents, Stents, Everolimus, Cardiology and Cardiovascular Medicine, Platelet Aggregation Inhibitors
Abstract

BACKGROUND: In the TWILIGHT trial, ticagrelor monotherapy after a short course of dual antiplatelet therapy (DAPT) was shown to be a safe bleeding avoidance strategy in high-risk patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). AIMS: The aim of this study was to evaluate the effects of ticagrelor monotherapy after three-month DAPT in patients undergoing PCI, according to DES type. METHODS: In the current sub-analysis from TWILIGHT, patients were stratified into three groups based on DES type: durable polymer everolimus-eluting stents (DP-EES), durable polymer zotarolimus-eluting stents (DP-ZES), and biodegradable polymer DES (BP-DES). Bleeding and ischaemic outcomes were assessed at one year after randomisation. RESULTS: Out of 5,769 patients, 3,014 (52.2%) had DP-EES, 1,350 (23.4%) had DP-ZES and 1,405 (24.4%) had BP-DES. Compared with ticagrelor plus aspirin, ticagrelor monotherapy had significantly lower BARC type 2, 3 or 5 bleeding compared with DAPT; DP-EES (3.8% vs 6.7%; HR 0.56, 95% CI: 0.41-0.78), DP-ZES (4.6% vs 6.9%; HR 0.66, 95% CI: 0.42-1.04) and BP-DES (4.2% vs 7.9%; HR 0.52, 95% CI: 0.33-0.81; p(interaction)=0.76). Ticagrelor monotherapy resulted in similar rates of death, MI, or stroke: DP-EES (4.2% vs 4.3%; HR 0.97; 95% CI: 0.68-1.37); DP-ZES (4.1% vs 3.1%; HR 1.32; 95% CI: 0.75-2.33); BP-DES (3.9% vs 4.2%; HR 0.92; 95% CI: 0.54-1.55; p(interaction)=0.60). In both unadjusted and covariate-adjusted analyses, DES type was not associated with any differences in ischaemic or bleeding complications. CONCLUSIONS: As compared with ticagrelor plus aspirin, ticagrelor monotherapy after a short DAPT duration lowered bleeding complications without increasing the ischaemic risk, irrespective of DES type. We observed no significant differences among DES types.

Published
2022

79. Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial

Author

Valgimigli, Marco, Gagnor, Andrea, Calabró, Paolo, Frigoli, Enrico, Leonardi, Sergio, Zaro, Tiziana, Rubartelli, Paolo, Briguori, Carlo, Andò, Giuseppe, Repetto, Alessandra, Limbruno, Ugo, Cortese, Bernardo, Sganzerla, Paolo, Lupi, Alessandro, Galli, Mario, Colangelo, Salvatore, Ierna, Salvatore, Ausiello, Arturo, Presbitero, Patrizia, Sardella, Gennaro, Varbella, Ferdinando, Esposito, Giovanni, Santarelli, Andrea, Tresoldi, Simone, Nazzaro, Marco, Zingarelli, Antonio, de Cesare, Nicoletta, Rigattieri, Stefano, Tosi, Paolo, Palmieri, Cataldo, Brugaletta, Salvatore, Rao, Sunil V, Heg, Dik, Rothenbühler, Martina, Vranckx, Pascal, and Jüni, Peter

Published
2015
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80. Zotarolimus-Eluting Versus Bare-Metal Stents in Uncertain Drug-Eluting Stent Candidates

Author

Valgimigli, Marco, Patialiakas, Athanasios, Thury, Attila, McFadden, Eugene, Colangelo, Salvatore, Campo, Gianluca, Tebaldi, Matteo, Ungi, Imre, Tondi, Stefano, Roffi, Marco, Menozzi, Alberto, de Cesare, Nicoletta, Garbo, Roberto, Meliga, Emanuele, Testa, Luca, Gabriel, Henrique Mesquita, Airoldi, Flavio, Ferlini, Marco, Liistro, Francesco, Dellavalle, Antonio, Vranckx, Pascal, and Briguori, Carlo

Published
2015
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82. Ticagrelor with and without aspirin in patients with a prior coronary artery bypass graft undergoing percutaneous coronary intervention: the TWILIGHT-CABG study

Author

Sardella, Gennaro, primary, Beerkens, Frans J., additional, Dangas, George, additional, Cao, Davide, additional, Baber, Usman, additional, Sartori, Samantha, additional, Cohen, David J., additional, Briguori, Carlo, additional, Gil, Robert, additional, Nicolas, Johny, additional, Zhang, Zhongjie, additional, Dudek, Dariusz, additional, Kunadian, Vijay, additional, Kornowski, Ran, additional, Weisz, Giora, additional, Claessen, Bimmer, additional, Marx, Steven, additional, Escaned, Javier, additional, Huber, Kurt, additional, Collier, Timothy, additional, Moliterno, David J., additional, Ohman, E. Magnus, additional, Krucoff, Mitchell W., additional, Kastrati, Adnan, additional, Steg, Phillipe Gabriel, additional, Angiolillo, Dominick J., additional, Mehta, Shamir, additional, Shlofmitz, Richard, additional, Sharma, Samin, additional, Pocock, Stuart, additional, Gibson, Charles Michael, additional, and Mehran, Roxana, additional

Published
2022
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83. Implications of worsening renal function before hospitalization for acute heart failure

Author

Wettersten, Nicholas, primary, Duff, Stephen, additional, Horiuchi, Yu, additional, van Veldhuisen, Dirk J., additional, Mueller, Christian, additional, Filippatos, Gerasimos, additional, Nowak, Richard, additional, Hogan, Christopher, additional, Kontos, Michael C., additional, Cannon, Chad M., additional, Müeller, Gerhard A., additional, Birkhahn, Robert, additional, Taub, Pam, additional, Vilke, Gary M., additional, McDonald, Kenneth, additional, Mahon, Niall, additional, Nuñez, Julio, additional, Briguori, Carlo, additional, Passino, Claudio, additional, Maisel, Alan, additional, Murray, Patrick T., additional, and Ix, Joachim H., additional

Published
2022
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84. Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure

Author

HORIUCHI, YU, primary, WETTERSTEN, NICHOLAS, additional, VAN VELDHUISEN, DIRK J., additional, MUELLER, CHRISTIAN, additional, FILIPPATOS, GERASIMOS, additional, NOWAK, RICHARD, additional, HOGAN, CHRISTOPHER, additional, KONTOS, MICHAEL C., additional, CANNON, CHAD M., additional, MÜELLER, GERHARD A., additional, BIRKHAHN, ROBERT, additional, TAUB, PAM, additional, VILKE, GARY M., additional, MCDONALD, KENNETH, additional, MAHON, NIALL, additional, NUÑEZ, JULIO, additional, BRIGUORI, CARLO, additional, PASSINO, CLAUDIO, additional, DUFF, STEPHEN, additional, MAISEL, ALAN, additional, and MURRAY, PATRICK T., additional

Published
2022
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86. Bleeding and Ischemic Outcomes With Ticagrelor Monotherapy According to Body Mass Index

Author

Kunadian, Vijay, primary, Baber, Usman, additional, Pivato, Carlo A., additional, Cao, Davide, additional, Dangas, George, additional, Sartori, Samantha, additional, Zhang, Zhongjie, additional, Angiolillo, Dominick J., additional, Briguori, Carlo, additional, Cohen, David J., additional, Collier, Timothy, additional, Dudek, Dariusz, additional, Gibson, Michael, additional, Gil, Robert, additional, Huber, Kurt, additional, Kaul, Upendra, additional, Kornowski, Ran, additional, Krucoff, Mitchell W., additional, Dehghani, Payam, additional, Mehta, Shamir, additional, Moliterno, David J., additional, Ohman, E. Magnus, additional, Escaned, Javier, additional, Sardella, Gennaro, additional, Sharma, Samin K., additional, Shlofmitz, Richard, additional, Weisz, Giora, additional, Witzenbichler, Bernhard, additional, Džavík, Vladimír, additional, Gurbel, Paul, additional, Hamm, Christian W., additional, Henry, Timothy, additional, Kastrati, Adnan, additional, Marx, Steven O., additional, Oldroyd, Keith, additional, Steg, P. Gabriel, additional, Pocock, Stuart, additional, and Mehran, Roxana, additional

Published
2022
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87. Guideline-Directed Medical Therapy Attainment and Outcomes in Dialysis-Requiring Versus Nondialysis Chronic Kidney Disease in the ISCHEMIA-CKD Trial

Author

Mathew, Roy O., primary, Maron, David J., additional, Anthopolos, Rebecca, additional, Fleg, Jerome L., additional, O’Brien, Sean M., additional, Rockhold, Frank W., additional, Briguori, Carlo, additional, Roik, Marek F., additional, Mazurek, Tomasz, additional, Demkow, Marcin, additional, Malecki, Robert, additional, Ye, Zhiming, additional, Kaul, Upendra, additional, Miglinas, Marius, additional, Stone, Gregg W., additional, Wald, Ron, additional, Charytan, David M., additional, Sidhu, Mandeep S., additional, Hochman, Judith S., additional, and Bangalore, Sripal, additional

Published
2022
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88. Antithrombotic strategy variability in atrial fibrillation and obstructive coronary disease revascularised with percutaneous coronary intervention: primary results from the AVIATOR 2 international registry

Author

Chandrasekhar, Jaya, primary, Baber, Usman, additional, Sartori, Samantha, additional, Goel, Ridhima, additional, Nicolas, Johny, additional, Vogel, Birgit, additional, Snyder, Clayton, additional, Kini, Annapoorna, additional, Briguori, Carlo, additional, Witzenbichler, Bernhard, additional, Iakovou, Ioannis, additional, Sardella, Gennaro, additional, Marzo, Kevin, additional, DeFranco, Anthony, additional, Stuckey, Thomas, additional, Chieffo, Alaide, additional, Colombo, Antonio, additional, Shlofmitz, Richard, additional, Capodanno, Davide, additional, Dangas, George, additional, Pocock, Stuart, additional, and Mehran, Roxana, additional

Published
2022
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91. One-year outcome of biolimus eluting stent with biodegradable polymer in all comers: The Italian Nobori Stent Prospective Registry

Author

Godino, Cosmo, Parenti, Dennis Zavalloni, Regazzoli, Damiano, Rutigliano, David, Lucisano, Luigi, Viani, Giacomo Maria, Spartera, Marco, Chieffo, Alaide, Donahue, Michael, Cappelletti, Alberto, Locuratolo, Nicola, Parisi, Rosario, Fattori, Rossella, Presbitero, Patrizia, Margonato, Alberto, Briguori, Carlo, Sardella, Gennaro, and Colombo, Antonio

Published
2014
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92. Impella RP for Patients with Acute Right Ventricular Failure and Cardiogenic Shock: A Subanalysis from the IMP-IT Registry

Author

Botti, Giulia, primary, Gramegna, Mario, additional, Burzotta, Francesco, additional, Masiero, Giulia, additional, Briguori, Carlo, additional, Trani, Carlo, additional, Napodano, Massimo, additional, Scandroglio, Anna Mara, additional, Montorfano, Matteo, additional, Tarantini, Giuseppe, additional, and Chieffo, Alaide, additional

Published
2022
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94. TCT-184 Impact of Coronary Calcification in Patients Presenting With Acute Coronary Syndromes: Insights From the MATRIX trial

Author

Sanchez, Jorge Sanz, primary, Garcia-Garcia, Hector, additional, Leonardi, Sergio, additional, Calabro, Paolo, additional, Briguori, Carlo, additional, Limbruno, Ugo, additional, Garbo, Roberto, additional, Russo, Filippo, additional, Lupi, Alessandro, additional, Esposito, Giuseppe, additional, Presbitero, Patrizia, additional, Santarelli, Andrea, additional, Sardella, Gennaro, additional, Varbella, Ferdinando, additional, Tresoldi, Simone, additional, De Cesare, Nicoletta, additional, Boccuzzi, Giacomo, additional, Omerovic, Elmir, additional, Heg, Dik, additional, and Vranckx, Pascal, additional

Published
2022
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96. TCT-13 Ticagrelor Monotherapy in Patients With Peripheral Artery Disease Undergoing PCI

Author

Spirito, Alessandro, primary, Cao, Davide, additional, Sartori, Samantha, additional, Zhang, Zhongjie, additional, Nicolas, Johny, additional, Cohen, David, additional, Angiolillo, Dominick, additional, Briguori, Carlo, additional, Vogel, Birgit, additional, Collier, Timothy, additional, Dudek, Dariusz, additional, Escaned, Javier, additional, Sharma, Samin, additional, Farhan, Serdar, additional, Huber, Kurt, additional, Kastrati, Adnan, additional, Kornowski, Ran, additional, Krucoff, Mitchell, additional, Kunadian, Vijay, additional, Mehta, Shamir, additional, Moliterno, David, additional, Ohman, E. Magnus, additional, Sardella, Gennaro, additional, Shlofmitz, Richard, additional, Steg, Philippe, additional, Witzenbichler, Bernhard, additional, Han, Yaling, additional, Pocock, Stuart, additional, Dangas, George, additional, and Mehran, Roxana, additional

Published
2022
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98. Impact of Selection Bias on Estimation of Subsequent Event Risk

Author

Hu, Yi-Juan, Schmidt, Amand F., Dudbridge, Frank, Holmes, Michael V., Brophy, James M., Tragante, Vinicius, Li, Ziyi, Liao, Peizhou, Quyyumi, Arshed A., McCubrey, Raymond O., Horne, Benjamin D., Hingorani, Aroon D., Asselbergs, Folkert W., Patel, Riyaz S., Long, Qi, Åkerblom, Axel, Algra, Ale, Allayee, Hooman, Almgren, Peter, Anderson, Jeffrey L., Andreassi, Maria G., Anselmi, Chiara V., Ardissino, Diego, Arsenault, Benoit J., Ballantyne, Christie M., Baranova, Ekaterina V., Behloui, Hassan, Bergmeijer, Thomas O., Bezzina, Connie R., Bjornsson, Eythor, Body, Simon C., Boeckx, Bram, Boersma, Eric (H.), Boerwinkle, Eric, Bogaty, Peter, Braund, Peter S., Breitling, Lutz P., Brenner, Hermann, Briguori, Carlo, Brugts, Jasper J., Burkhardt, Ralph, Cameron, Vicky A., Carlquist, John F., Carpeggiani, Clara, Carruthers, Kathryn F., Casu, Gavino, Condorelli, Gianluigi, Cresci, Sharon, Danchin, Nicolas, de Faire, Ulf, Deanfield, John, Delgado, Graciela, Deloukas, Panos, Direk, Kenan, Doughty, Robert N., Drexel, Heinz, Duarte, Nubia E., Dubé, Marie-Pierre, Dufresne, Line, Engert, James C., Eriksson, Niclas, Fitzpatrick, Natalie, Foco, Luisa, Ford, Ian, Fox, Keith A.A., Gigante, Bruna, Gijsberts, Crystel M., Girelli, Domenico, Gong, Yan, Gudbjartsson, Daniel F., Hagström, Emil, Hartiala, Jaana, Hazen, Stanley L., Held, Claes, Helgadottir, Anna, Hemingway, Harry, Heydarpour, Mahyar, Hoefer, Imo E., Hovingh, Kees, Hubacek, Jaroslav A., James, Stefan, Johnson, Julie A., Wouter Jukema, J., Kaczor, Marcin P., Kaminski, Karol A., Kettner, Jiri, Kiliszek, Marek, Kleber, Marcus, Klungel, Olaf H., Kofink, Daniel, Kohonen, Mika, Kotti, Salma, Kuukasjärvi, Pekka, Lagerqvist, Bo, Lambrechts, Diether, Lang, Chim C., Laurikka, Jari O., Leander, Karin, Lee, Vei-Vei, Lehtimäki, Terho, Leiherer, Andreas, Lenzini, Petra A., Levin, Daniel, Lindholm, Daniel, Lokki, Marja-Liisa, Lotufo, Paulo A., Lyytikäinen, Leo-Pekka, Khan Mahmoodi, B., Maitland-van der Zee, Anke H., Martinelli, Nicola, März, Winfried, Marziliano, Nicola, McPherson, Ruth, Melander, Olle, Mons, Ute, Muehlschlegel, Jochen D., Muhlestein, Joseph B., Nelson, Cristopher P., Newton Cheh, Chris, Olivieri, Oliviero, Opolski, Grzegorz, Palmer, Colin N., Pare, Guillaume, Pasterkamp, Gerard, Pepine, Carl J., Pepinski, Witold, Pereira, Alexandre C., Pilbrow, Anna P., Pilote, Louise, Pitha, Jan, Ploski, Rafal, Mark Richards, A., Saely, Christoph H., Samani, Nilesh J., Samman-Tahhan, Ayman, Sanak, Marek, Sandesara, Pratik B., Sattar, Naveed, Scholz, Markus, Siegbahn, Agneta, Simon, Tabassome, Sinisalo, Juha, Gustav Smith, J., Spertus, John A., Stefansson, Kari, Stewart, Alexandre F.R., Stott, David J., Szczeklik, Wojciech, Szpakowicz, Anna, Tanck, Michael W.T., Tang, Wilson H., Tardif, Jean-Claude, ten Berg, Jur M., Teren, Andrej, Thanassoulis, George, Thiery, Joachim, Thorgeirsson, Gudmundur, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Timmis, Adam, Trompet, Stella, van de Werf, Frans, van der Graaf, Yolanda, van der Haarst, Pim, van der Laan, Sander W., Vilmundarson, Ragnar O., Virani, Salim S., Visseren, Frank L.J., Vlachopoulou, Efthymia, Wallentin, Lars, Waltenberger, Johannes, Wauters, Els, and Wilde, Arthur A.M.

Published
2017
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