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299 results on '"Brenner, Rolf E."'

53. Autorinnen und Autoren

Author

Ahrens, Wiebke, primary, Baumann, Michael A., additional, Behrens, Rolf, additional, Belohradsky, Bernd H., additional, Böhles, Hansjosef, additional, Brämswig, Jürgen H., additional, Brandl, Ulrich, additional, Brenner, Rolf E., additional, Brockmeier, Konrad, additional, and Büscher, Rainer, additional

Published
2005
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57. Initial Harm Reduction by N-Acetylcysteine Alleviates Cartilage Degeneration after Blunt Single-Impact Cartilage Trauma in Vivo

Author

Riegger, Jana, Leucht, Frank Martin, Palm, Hans-Georg, Ignatius, Anita, and Brenner, Rolf E.

Subjects
DDC 540 / Chemistry & allied sciences, Knochen-Morphogenese-Proteine, Post-traumatic osteoarthritis, Bone Morphogenetic Protein 7, histomorphology, Wounds, Nonpenetrating, lcsh:Chemistry, DDC 570 / Life sciences, Bone morphogenic protein 7, ddc:570, Matrix Metalloproteinase 13, Osteoarthritis, Arthrose, Animals, Regeneration, post-traumatic osteoarthritis, ddc:610, lcsh:QH301-705.5, Collagen Type II, therapy, bone morphogenic protein 7, Communication, Therapy, cartilage trauma, N-acetylcysteine, Acetylcysteine, Cartilage trauma, Cartilage, lcsh:Biology (General), lcsh:QD1-999, ddc:540, Female, Histomorphology, Rabbits, Acetylcystein, DDC 610 / Medicine & health
Abstract

Joint injuries are highly associated with the development of post-traumatic osteoarthritis. Previous studies revealed cell- and matrix-protective e ects of N-acetylcysteine (NAC) after ex vivo cartilage trauma, while chondroanabolic stimulation with bone morphogenetic protein 7 (BMP7) enhanced type II collagen (COL2) expression. Here, as a next step, we investigated the combined and individual e cacy of intra-articular antioxidative and chondroanabolic treatment in a rabbit in vivo cartilage trauma model. Animals were randomly divided into group A (right joint: trauma (T); left joint: T+BMP7) and group B (right joint: T+NAC; left joint: T+BMP7+NAC). Condyles were impacted with the use of a spring-loaded impact device to ensure defined, single trauma administration. After 12 weeks, histopathological analysis was performed and the presence of matrix metalloproteinase 13 (MMP-13) and COL2 was assessed. Trauma-induced hypocellularity, MMP-13 expression, and cell cluster formation were reduced in NAC-treated animals. In contrast, BMP7 further increased cluster formation. Moreover, synovial concentrations of COL2 carboxy propeptide (CPII) and proteoglycan staining intensities were enhanced in NAC- and NAC+BMP7-treated joints. For the first time, the e cacy of NAC regarding early harm reduction after blunt cartilage trauma was demonstrated in vivo. However, parallel administration of BMP7 was not significantly superior compared to NAC alone., publishedVersion

Published
2019

62. Recessive multiple epiphyseal dysplasia (rMED) with homozygosity for C653S mutation in the DTDST gene - Phenotype, molecular diagnosis and surgical treatment of habitual dislocation of multilayered patella: Case report

Author

Bonafé Luisa, Scheiderer Wolf-Dieter, Superti-Furga Andrea, Hinrichs Timo, Brenner Rolf E, and Mattes Thomas

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Multiple epiphyseal dysplasia (MED) is one of the more common generalised skeletal dysplasias. Due to its clinical heterogeneity diagnosis may be difficult. Mutations of at least six separate genes can cause MED. Joint deformities, joint pain and gait disorders are common symptoms. Case Presentation We report on a 27-year-old male patient suffering from clinical symptoms of autosomal recessive MED with habitual dislocation of a multilayered patella on both sides, on the surgical treatment and on short-term clinical outcome. Clinical findings were: bilateral hip and knee pain, instability of femorotibial and patellofemoral joints with habitual patella dislocation on both sides, contractures of hip, elbow and second metacarpophalangeal joints. Main radiographic findings were: bilateral dislocated multilayered patella, dysplastic medial tibial plateaus, deformity of both femoral heads and osteoarthritis of the hip joints, and deformity of both radial heads. In the molecular genetic analysis, the DTDST mutation g.1984T > A (p.C653S) was found at the homozygote state. Carrier status was confirmed in the DNA of the patient's parents. The mutation could be considered to be the reason for the patient's disease. Surgical treatment of habitual patella dislocation with medialisation of the tibial tuberosity led to an excellent clinical outcome. Conclusions The knowledge of different phenotypes of skeletal dysplasias helps to select genes for genetic analysis. Compared to other DTDST mutations, this is a rather mild phenotype. Molecular diagnosis is important for genetic counselling and for an accurate prognosis. Even in case of a multilayered patella in MED, habitual patella dislocation could be managed successfully by medialisation of the tibial tuberosity.

Published
2010
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63. CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells

Author

Jakob Franz, Mattes Thomas, Fiedler Jörg, Schenk Rita, Schütze Norbert, and Brenner Rolf E

Subjects
Cytology, QH573-671
Abstract

Abstract Background: CCN-proteins are known to be involved in development, homeostasis and repair of mesenchymal tissues. Since these processes implicate recruitment of cells with the potential to be committed to various phenotypes, we studied the effect of CYR61/CCN1 and WISP3/CCN6 on migration of human bone marrow derived mesenchymal stroma cells (MSCs) in comparison to in vitro osteogenic differentiated MSCs using a modified Boyden chamber assay. Results: CYR61 and WISP3 were purified as fusion proteins with a C-terminal Fc-tag from baculovirus infected SF21 cells using protein G sepharose columns. CYR61 and WISP3 stimulated cell migration of undifferentiated MSCs in a dose-dependent manner. CYR61 and WISP3 had similar effects on committed osteogenic precursor cells. Checkerboard analysis revealed that CYR61 and WISP3 stimulated true directed cell migration (chemotaxis) of MSCs and committed osteogenic precursors. In MSCs the chemotactic activity of WISP3 but not CYR61 was mediated through integrin ανß5. Conclusion: Our results indicate that CYR61 and WISP3 can function as soluble ligands transmitting chemotactic signals to human MSCs but differ in the involvement of integrin ανß5. This may be relevant for their possible role in connective tissue repair.

Published
2007
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76. The Anaphylatoxin Receptor C5aR Is Present During Fracture Healing in Rats and Mediates Osteoblast Migration In Vitro

Author

Ignatius, Anita, primary, Ehrnthaller, Christian, additional, Brenner, Rolf E., additional, Kreja, Ludwika, additional, Schoengraf, Philipp, additional, Lisson, Patricia, additional, Blakytny, Robert, additional, Recknagel, Stefan, additional, Claes, Lutz, additional, Gebhard, Florian, additional, Lambris, John D., additional, and Huber-Lang, Markus, additional

Published
2011
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96. Classic, atypically severe and neonatal Marfan syndrome: twelve mutations and genotype–phenotype correlations in FBN1 exons 24–40

Author

Tiecke, Frank, primary, Katzke, Stefanie, additional, Booms, Patrick, additional, Robinson, Peter N, additional, Neumann, Luitgard, additional, Godfrey, Maurice, additional, Mathews, Kurt R, additional, Scheuner, Maren, additional, Hinkel, Georg Klaus, additional, Brenner, Rolf E, additional, Hövels-Gürich, Hedwig H, additional, Hagemeier, Christian, additional, Fuchs, Josefine, additional, Skovby, Flemming, additional, and Rosenberg, Thomas, additional

Published
2001
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