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54. miR135a administration ameliorates brain ischemic damage by preventing TRPM7 activation during brain ischemia.

Author

Cepparulo, P., Brancaccio, P., Sirabella, R., Anzilotti, S., Guida, N., Laudati, G., Valsecchi, V., Vinciguerra, A., Viscardi, V., D'Esposito, L., Formisano, L., Annunziato, L., Pignataro, G., and Cuomo, O.

Subjects
*CEREBRAL ischemia, *BRAIN damage, *ARTERIAL occlusions, *CEREBRAL arteries, *THERAPEUTICS
Abstract

Background: miRNA‐based strategies have recently emerged as a promising therapeutic approach in several neurodegenerative diseases. Unregulated cation influx is implicated in several cellular mechanisms underlying neural cell death during ischemia. The brain constitutively active isoform of transient receptor potential melastatin 7 (TRPM7) represents a glutamate excitotoxicity‐independent pathway that significantly contributes to the pathological Ca2+ overload during ischemia. Aims: In the light of these premises, inhibition of TRPM7 may be a reasonable strategy to reduce ischemic injury. Since TRPM7 is a putative target of miRNA135a, the aim of the present paper was to evaluate the role played by miRNA135a in cerebral ischemia. Therefore, the specific objectives of the present paper were: (1) to evaluate miR135a expression in temporoparietal cortex of ischemic rats; (2) to investigate the effect of the intracerebroventricular (icv) infusion of miR135a on ischemic damage and neurological functions; and (3) to verify whether miR135a effects may be mediated by an alteration of TRPM7 expression. Methods: miR135a expression was evaluated by RT‐ PCR and FISH assay in temporoparietal cortex of ischemic rats. Ischemic volume and neurological functions were determined in rats subjected to transient middle cerebral artery occlusion (tMCAo) after miR135a intracerebroventricular perfusion. Target analysis was performed by Western blot. Results: Our results demonstrated that, in brain cortex, 72 h after ischemia, miR135a expression increased, while TRPM7 expression was parallelly downregulated. Interestingly, miR135a icv perfusion strongly ameliorated the ischemic damage and improved neurological functions, and downregulated TRPM7 protein levels. Conclusions: The early prevention of TRPM7 activation is protective during brain ischemia. [ABSTRACT FROM AUTHOR]

Published
2024
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55. The PULSE Vision & Change Rubrics, Version 1.0: A Valid and Equitable Tool to Measure Transformation of Life Sciences Departments at All Institution Types

Author

Brancaccio-Taras, Loretta, Pape-Lindstrom, Pamela, Peteroy-Kelly, Marcy, Aguirre, Karen, Awong-Taylor, Judy, Balser, Teri, Cahill, Michael J., Frey, Regina F., Jack, Thomas, Kelrick, Michael, Marley, Kate, Miller, Kathryn G., Osgood, Marcy, Romano, Sandra, Uzman, J. Akif, and Zhao, Jiuqing

Abstract

The PULSE Vision & Change Rubrics, version 1.0, assess life sciences departments' progress toward implementation of the principles of the "Vision and Change report." This paper reports on the development of the rubrics, their validation, and their reliability in measuring departmental change aligned with the "Vision and Change" recommendations. The rubrics assess 66 different criteria across five areas: Curriculum Alignment, Assessment, Faculty Practice/Faculty Support, Infrastructure, and Climate for Change. The results from this work demonstrate the rubrics can be used to evaluate departmental transformation equitably across institution types and represent baseline data about the adoption of the "Vision and Change" recommendations by life sciences programs across the United States. While all institution types have made progress, liberal arts institutions are farther along in implementing these recommendations. Generally, institutions earned the highest scores on the Curriculum Alignment rubric and the lowest scores on the Assessment rubric. The results of this study clearly indicate that the Vision & Change Rubrics, version 1.0, are valid and equitable and can track long-term progress of the transformation of life sciences departments. In addition, four of the five rubrics have broad applicability and can be used to evaluate departmental transformation by other science, technology, engineering, and mathematics disciplines.

Published
2016
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58. Predicting de‐novoportal vein thrombosis after HCV eradication: A long‐term competing risk analysis in the ongoing PITER cohort

Author

Kondili, Loreta A., Zanetto, Alberto, Quaranta, Maria Giovanna, Ferrigno, Luigina, Panetta, Valentina, Calvaruso, Vincenza, Zignego, Anna Linda, Brunetto, Maurizia R., Raimondo, Giovanni, Biliotti, Elisa, Ieluzzi, Donatella, Iannone, Andrea, Madonia, Salvatore, Chemello, Liliana, Cavalletto, Luisa, Coppola, Carmine, Morisco, Filomena, Barbaro, Francesco, Licata, Anna, Federico, Alessandro, Cerini, Federica, Persico, Marcello, Pompili, Maurizio, Ciancio, Alessia, Piscaglia, Fabio, Chessa, Luchino, Giacometti, Andrea, Invernizzi, Pietro, Brancaccio, Giuseppina, Benedetti, Antonio, Baiocchi, Leonardo, Gentile, Ivan, Coppola, Nicola, Nardone, Gerardo, Craxì, Antonio, Russo, Francesco Paolo, Monti, Monica, Coco, Barbara, Filomia, Roberto, Bruno, Erica Maria, Cossiga, Valentina, Amodeo, Simona, Dallio, Marcello, Crapanzano, Luciano, Masarone, Mario, De Siena, Martina, Serio, Ilaria, Loi, Martina, Brescini, Lucia, Ciaccio, Antonio, Cucco, Monica, Tata, Xhimi, Sagnelli, Caterina, Sgamato, Costantino, Claar, Ernesto, Rosselli Del Turco, Elena, Rumi, Maria Grazia, Gaeta, Giovanni Battista, and Simioni, Paolo

Abstract

Sustained virological response (SVR) by direct‐acting antivirals (DAAs) may reverse the hypercoagulable state of HCV cirrhosis and the portal vein thrombosis (PVT) risk. We evaluated the incidence and predictive factors of de novo, non‐tumoral PVT in patients with cirrhosis after HCV eradication. Patients with HCV‐related cirrhosis, consecutively enrolled in the multi‐center ongoing PITER cohort, who achieved the SVR using DAAs, were prospectively evaluated. Kaplan‐Meier and competing risk regression analyses were performed. During a median time of 38.3 months (IQR: 25.1–48.7 months) after the end of treatment (EOT), among 1609 SVR patients, 32 (2.0%) developed de novo PVT. A platelet count ≤120,000/μL, albumin levels ≤3.5 mg/dL, bilirubin >1.1 mg/dL, a previous liver decompensation, ALBI, Baveno, FIB‐4, and RESIST scores were significantly different (p< 0.001), among patients who developed PVT versus those who did not. Considering death and liver transplantation as competing risk events, esophageal varices (subHR: 10.40; CI 95% 4.33–24.99) and pre‐treatment ALBI grade ≥2 (subHR: 4.32; CI 95% 1.36–13.74) were independent predictors of PVT. After HCV eradication, a significant variation in PLT count, albumin, and bilirubin (p< 0.001) versus pre‐treatment values was observed in patients who did not develop PVT, whereas no significant differences were observed in those who developed PVT (p> 0.05). After the EOT, esophageal varices and ALBI grade ≥2, remained associated with de novo PVT (subHR: 9.32; CI 95% 3.16–27.53 and subHR: 5.50; CI 95% 1.67–18.13, respectively). In patients with HCV‐related cirrhosis, a more advanced liver disease and significant portal hypertension are independently associated with the de novo PVT risk after SVR.

Published
2024
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63. Gender differences in chronic liver diseases in two cohorts of 2001 and 2014 in Italy

Author

Sagnelli, Evangelista, Stroffolini, Tommaso, Sagnelli, Caterina, Pirisi, Mario, Babudieri, Sergio, Colloredo, Guido, Russello, Maurizio, Coppola, Nicola, Gaeta, Giovanni Battista, Cacopardo, Bruno, De Luca, Massimo, Almasio, Piero Luigi, Andriulli, Angelo, Babudieri, Sergio, Brancaccio, Giuseppina, Cacopardo, Bruno, Colloredo, Guido, Coppola, Nicola, De Luca, Massimo, Furlan, Caterina, Licata, Anna, Morisco, Filomena, Pirisi, Mario, Pisaturo, Mariantonietta, Rosina, Floriano, Rusello, Maurizio, Sagnelli, Caterina, Santantonio, Teresa, Smedile, Antonina, and on behalf of EPACRON study group

Published
2017
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66. EUS-guided gallbladder drainage using a lumen-apposing metal stent as rescue treatment for malignant distal biliary obstruction: a large multicenter experience.

Author

Binda, Cecilia, Anderloni, Andrea, Fugazza, Alessandro, Amato, Arnaldo, de Nucci, Germana, Redaelli, Alessandro, Di Mitri, Roberto, Cugia, Luigi, Pollino, Valeria, Macchiarelli, Raffaele, Mangiavillano, Benedetto, Forti, Edoardo, Brancaccio, Mario Luciano, Badas, Roberta, Maida, Marcello, Sinagra, Emanuele, Repici, Alessandro, Fabbri, Carlo, and Tarantino, Ilaria

Abstract

EUS-guided gallbladder drainage (EUS-GBD) with lumen-apposing metal stents (LAMSs) has been reported as a rescue treatment with encouraging results for the relief of jaundice in patients with distal malignant biliary obstruction (DMBO) and after failure of both ERCP and EUS-guided choledochoduodenostomy. This was a multicenter retrospective analysis of all cases of consecutive EUS-GBD with LAMSs used as a rescue treatment for patients with DMBO in 14 Italian centers from June 2015 to June 2020. Primary endpoints were technical and clinical success, whereas the secondary endpoint was the adverse event (AE) rate. Forty-eight patients (52.1% women) with a mean age of 74.3 ± 11.7 years were included in the study. Biliary stricture was related to pancreatic adenocarcinoma (85.4%), duodenal adenocarcinoma (2.1%), cholangiocarcinoma (4.2%), ampullary cancer (2.1%), colon cancer (4.2%), and metastatic breast cancer (2.1%). The mean diameter of the common bile duct was 13.3 ± 2.8 mm. LAMSs were placed transgastrically in 58.3% of cases and transduodenally in 41.7%. Technical success was 100%, whereas clinical success was 81.3%, with a mean total bilirubin reduction after 2 weeks of 66.5%. The mean procedure time was 26.4 minutes, and the mean hospital stay was 9.2 ± 8.2 days. AEs occurred in 5 patients (10.4%): 3 were classified as intraprocedural and 2 were classified as delayed because they occurred after >15 days. When the American Society for Gastrointestinal Endoscopy lexicon was used, 2 AEs were mild and 3 were moderate (2 buried LAMSs). The mean follow-up was 122 days. Our study shows that EUS-GBD with LAMSs used as a rescue treatment for patients affected by DMBO represents a valuable option in terms of technical and clinical success rates, with an acceptable AE rate. To the best of our knowledge, this is the largest study concerning the use of this procedure. (Clinical trial registration number: NCT03903523.) [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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67. The relationship between the history of PDE5-inhibitors assumption and melanoma: a systematic review.

Author

Cilio, Simone, Briatico, Giulia, Brancaccio, Gabriella, Capone, Federico, Ferro, Matteo, Imbimbo, Ciro, Salonia, Andrea, Argenziano, Giuseppe, and Crocetto, Felice

Subjects
ONLINE information services, MEDICAL databases, IMPOTENCE, MEDICAL information storage & retrieval systems, MELANOMA, SYSTEMATIC reviews, RISK assessment, DESCRIPTIVE statistics, MEDLINE, PHOSPHODIESTERASE inhibitors, DISEASE risk factors
Abstract

Phosphodiesterase 5 inhibitors (PDE5-is) are used worldwide as first line therapy for erectile dysfunction (ED). Current literature reported data on the warning association between PDE5-is use and the development of cutaneous melanoma. However, these data are contrasting, thus we aim to summarise evidence regarding this association. A systematic review of all published articles related to the effects of PDE5-is in the development of cutaneous melanoma was performed. PubMed, EMBASE, and Cochrane library were queried for all the published studies indexed up to the 26th of May 2023. A combination of keywords related to PDE5-is and melanoma were used. Only original studies based on human subjects in the English language were included in the analysis. Of 505 articles identified, only eight original articles were considered for further analysis. Overall, five of the selected articles including 657,984 subjects agrees on an increased risk of developing melanoma in PDE5-is users. On the other hand, three original articles based on data regarding 360,915 subjects, disagree with the previous statement declaring any association between PDE5-i use and melanoma. Current literature still reports contrasting data regarding the association between PDE5-is assumption and increased risk of melanoma, but a possible association is described, bringing attention to higher risk melanoma category of patients. More clinical studies are needed to clarify the impact of PDE5-is in the development and progression of melanoma. [ABSTRACT FROM AUTHOR]

Published
2023
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68. Does letting adolescent and young adult inpatients share decisions in choosing the central-line insertion site reduce central-line-associated bloodstream infections? An empty systematic review

Author

Rosati, Paola, Crocoli, Alessandro, Saulle, Rosella, Amato, Laura, Brancaccio, Matilde, Mitrova, Zuzana, Ciliento, Gaetano, Ciofi degli Atti, Marta, and Raponi, Massimiliano

Abstract

To study whether allowing adolescents and young adults (AYA) with chronic or oncologic diseases admitted to tertiary or intensive care units to share decisions in choosing the insertion site for central-venous catheters (CVC) implanted for intravenous therapies or parenteral nutrition reduces central-line-associated and catheter-related bloodstream infections (CLABSI and CRBSI). Following the PRISMA guidelines, we systematically reviewed the literature by searching MEDLINE, Embase, CINAHL, CENTRAL, SCOPUS, Cochrane Library, and Web of Science up to December 2019. According to our aims, the review identified no study that could be included. This empty systematic review on healthcare teams allowing AYA with chronic or oncologic diseases admitted in tertiary or intensive care units to share decisions in choosing the site for implanting CVC prompts further research on clinical pathways on this hot-topic. By considering purportedly risk-taking behaviors in youngsters thus reducing CLABSI and CRBSI, healthcare teams should test specific strategies by engaging AYA empathetically in sharing decisions on the site for implanting CVC to improve quality in health care bundles.

Published
2024
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69. Profiling the risk of hepatocellular carcinoma after long-term HCV eradication in patients with liver cirrhosis in the PITER cohort.

Author

Kondili, Loreta A., Quaranta, Maria Giovanna, Cavalletto, Luisa, Calvaruso, Vincenza, Ferrigno, Luigina, D'Ambrosio, Roberta, Simonelli, Ilaria, Brancaccio, Giuseppina, Raimondo, Giovanni, Brunetto, Maurizia R., Zignego, Anna Linda, Coppola, Carmine, Iannone, Andrea, Biliotti, Elisa, Verucchi, Gabriella, Massari, Marco, Licata, Anna, Barbaro, Francesco, Persico, Marcello, and Russo, Francesco Paolo

Abstract

Severe liver disease markers assessed before HCV eradication are acknowledged to usually improve after the SVR. We prospectively evaluated, in the PITER cohort, the long-term HCC risk profile based on predictors monitored after HCV eradication by direct-acting antivirals in patients with cirrhosis. HCC occurrence was evaluated by Kaplan-Meier analysis. Cox regression analysis identified the post-treatment variables associated with de-novo HCC; their predictive power was presented in a nomogram. After the end of therapy (median follow-up:28.47 months), among 2064 SVR patients, 119 (5.8%) developed de-novo HCC. The HCC incidence was 1.90%, 4.21%, 6.47% at 12-, 24- and 36-months from end-of-therapy, respectively (incidence rate 2.45/100 person-years). Age, genotype 3, diabetes, platelets (PLT)≤120,000/µl and albumin ≤3.5g/dl levels were identified as pre-treatment HCC independent predictors. Adjusting for age, the post-treatment PLT≤120,000/µl (AdjHR 1.92; 95%CI:1.06-3.45) and albumin≤3.5g/dl (AdjHR 4.38; 95%CI 2.48-7.75) values were independently associated with HCC occurrence. Two different risk profiles were identified by combining long-term post-therapy evaluation of PLT ≤ vs. >120,000/µl and albumin ≤ vs. >3.5g/dl showing a significant different HCC incidence rate of 1.35 vs. 3.77/100 p-y, respectively. The nomogram score based on age, PLT and albumin levels after SVR showed an accurate prediction capability and may support the customizing management for early HCC detection. [ABSTRACT FROM AUTHOR]

Published
2023
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72. Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na+/Ca2+ exchanger 3 downregulation

Author

Anzilotti, Serenella, Brancaccio, Paola, Simeone, Giuseppe, Valsecchi, Valeria, Vinciguerra, Antonio, Secondo, Agnese, Petrozziello, Tiziana, Guida, Natascia, Sirabella, Rossana, Cuomo, Ornella, Cepparulo, Pasquale, Herchuelz, Andrè, Amoroso, Salvatore, Di Renzo, Gianfranco, Annunziato, Lucio, and Pignataro, Giuseppe

Published
2018
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74. Symposium: Journalism and Mass Communication Education at the Crossroads.

Author

Cohen, Jeremy, Brancaccio, David, and Dates, Jannette

Abstract

Presents nine responses of professors and communication professionals to the ethical, economic, and enduring issues of journalism and mass communication education. Considers their responses to the state of journalism and mass communication education and reevaluates educational assumptions and practices. (SG)

Published
2001

75. X-ray tomography of large wooden artworks: the case study of "Doppio corpo" by Pietro Piffetti

Author

Re, Alessandro, Albertin, Fauzia, Avataneo, Chiara, Brancaccio, Rosa, Corsi, Jacopo, Cotto, Giorgio, De Blasi, Stefania, Dughera, Giovanni, Durisi, Elisabetta, Ferrarese, Walter, Giovagnoli, Annamaria, Grassi, Novella, Lo Giudice, Alessandro, Mereu, Paolo, Mila, Giorgia, Nervo, Marco, Pastrone, Nadia, Prino, Francesco, Ramello, Luciano, Ravera, Massimo, Ricci, Chiara, Romero, Alessandra, Sacchi, Roberto, Staiano, Amedeo, Visca, Lorenzo, and Zamprotta, Lorenzo

Published
2014
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77. GATA3 (GATA-binding protein 3)/KMT2A (lysine-methyltransferase-2A) complex by increasing H3K4-3me (trimethylated lysine-4 of histone-3) upregulates NCX3 (Na+-Ca2+exchanger 3) transcription and contributes to ischemic preconditioning neuroprotection

Author

Guida N., Mascolo L., Serani A., Cuomo O., Anzilotti S., Brancaccio P., Pignataro G., Molinaro P., Annunziato L., Formisano L., Guida, N., Mascolo, L., Serani, A., Cuomo, O., Anzilotti, S., Brancaccio, P., Pignataro, G., Molinaro, P., Annunziato, L., and Formisano, L.

Subjects
Histone, Ischemic preconditioning, Neuroprotection oxygen, Methyltransferase
Abstract

BACKGROUND AND PURPOSE: NCX3 (Na+-Ca2+ exchanger 3) plays a relevant role in stroke; indeed its pharmacological blockade or its genetic ablation exacerbates brain ischemic damage, whereas its upregulation takes part in the neuroprotection elicited by ischemic preconditioning. To identify an effective strategy to induce an overexpression of NCX3, we examined transcription factors and epigenetic mechanisms potentially involved in NCX3 gene regulation. METHODS: Brain ischemia and ischemic preconditioning were induced in vitro by exposure of cortical neurons to oxygen and glucose deprivation plus reoxygenation (OGD/Reoxy) and in vivo by transient middle cerebral artery occlusion. Western blot and quantitative real-time polymerase chain reaction were used to evaluate transcripts and proteins of GATA3 (GATA-binding protein 3), KMT2A (lysine-methyltransferase-2A), and NCX3. GATA3 and KMT2A binding on NCX3 gene was evaluated by chromatin immunoprecipitation and Rechromatin immunoprecipitation experiments. RESULTS: Among the putative transcription factors sharing a consensus sequence on the ncx3 brain promoter region, GATA3 was the only able to up-regulate ncx3. Interestingly, GATA3 physically interacted with KMT2A, and their overexpression or knocking-down increased or downregulated NCX3 mRNA and protein, respectively. Notably, site-direct mutagenesis of GATA site on ncx3 brain promoter region counteracted GATA3 and KMT2A binding on NCX3 gene. More importantly, we found that in the perischemic cortical regions of preconditioned rats GATA3 recruited KMT2A and the complex H3K4-3me (trimethylated lysine-4 of histone-3) on ncx3 brain promoter region, thus reducing transient middle cerebral artery occlusion–induced damage. Consistently, in vivo silencing of either GATA3 or KMT2A prevented NCX3 upregulation and consequently the neuroprotective effect of preconditioning stimulus. The involvement of GATA3/KMT2A complex in neuroprotection elicited by ischemic preconditioning was further confirmed by in vitro experiments in which the knocking-down of GATA3 and KMT2A reverted the neuroprotection induced by NCX3 overexpression in cortical neurons exposed to anoxic preconditioning followed by oxygen and glucose deprivation plus reoxygenation. CONCLUSIONS: Collectively, our results revealed that GATA3/KMT2A complex epigenetically activates NCX3 gene transcription during ischemic preconditioning.

Published
2021

86. Pharmacist gender and physician acceptance of antibiotic stewardship recommendations: An analysis of the reducing overuse of antibiotics at discharge home intervention

Author

Vaughn, Valerie M., Giesler, Daniel L., Mashrah, Daraoun, Brancaccio, Adamo, Sandison, Katie, Spivak, Emily S., Szymczak, Julia E., Wu, Chaorong, Horowitz, Jennifer K., Bashaw, Linda, and Hersh, Adam L.

Abstract

AbstractObjective:To assess association of pharmacist gender with acceptance of antibiotic stewardship recommendations.Design:A retrospective evaluation of the Reducing Overuse of Antibiotics at Discharge (ROAD) Home intervention.Setting:The study was conducted from May to October 2019 in a single academic medical center.Participants:The study included patients receiving antibiotics on a hospitalist service who were nearing discharge.Methods:During the intervention, clinical pharmacists (none who had specialist postgraduate infectious disease residency training) reviewed patients on antibiotics and led an antibiotic timeout (ie, structured conversation) prior to discharge to improve discharge antibiotic prescribing. We assessed the association of pharmacist gender with acceptance of timeout recommendations by hospitalists using logistic regression controlling for patient characteristics.Results:Over 6 months, pharmacists conducted 295 timeouts: 158 timeouts (53.6%) were conducted by 12 women, 137 (46.4%) were conducted by 8 men. Pharmacists recommended an antibiotic change in 82 timeouts (27.8%), of which 51 (62.2%) were accepted. Compared to male pharmacists, female pharmacists were less likely to recommend a discharge antibiotic change: 30 (19.0%) of 158 versus 52 (38.0%) of 137 (P < .001). Female pharmacists were also less likely to have a recommendation accepted: 10 (33.3%) of 30 versus 41 (8.8%) of 52 (P < .001). Thus, timeouts conducted by female versus male pharmacists were less likely to result in an antibiotic change: 10 (6.3%) of 158 versus 41 (29.9%) of 137 (P < .001). After adjustments, pharmacist gender remained significantly associated with whether recommended changes were accepted (adjusted odds ratio [aOR], 0.10; 95%confidence interval [CI], 0.03–0.36 for female versus male pharmacists).Conclusions:Antibiotic stewardship recommendations made by female clinical pharmacists were less likely to be accepted by hospitalists. Gender bias may play a role in the acceptance of clinical pharmacist recommendations, which could affect patient care and outcomes.

Published
2023
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89. Hepatitis delta coinfection in persons with HIV: misdiagnosis and disease burden in Italy

Author

Brancaccio, Giuseppina, Shanyinde, Milensu, Puoti, Massimo, Gaeta, Giovanni B., Monforte, Antonella D’ARMINIO, Vergori, Alessandra, Rusconi, Stefano, Mazzarelli, Antonio, Castagna, Antonella, Antinori, Andrea, and Cozzi-Lepri, Alessandro

Abstract

ABSTRACTHepatitis Delta virus (HDV) causes severe liver disease. Due to similarities in transmission routes, persons living with HIV (PLWH) are at risk of HDV infection. This analysis investigates the prevalence and the long-term clinical outcome of people with HDV in a large cohort of PLWH. We retrieved HBsAg ± anti-HDV positive PLWH enrolled from 1997 to 2015 in the multicentre, prospective ICONA study. The primary endpoint was a composite clinical outcome (CCO = having experienced ≥1 of the following: Fib4 score >3.25; diagnosis of cirrhosis; decompensation; hepatocellular carcinoma or liver-related death). Kaplan–Meier curves and unweighted and weighted Cox regression models were used for data analysis. Less than half of HBsAg positive patients had been tested for anti-HDV in clinical practice. After testing stored sera, among 617 HBV/HIV cases, 115 (19%) were anti-HDV positive; 405 (65%) HBV monoinfected; 99 (16%) undeterminate. The prevalence declined over the observation period. HDV patients were more often males, intravenous drug users, HCV coinfected. After a median of 26 months, 55/115 (48%) developed CCO among HDV+; 98/403 (24%) among HBV monoinfected; 18/99 (18%) in HDV unknown (p < 0.001). After controlling for geographical region, alcohol consumption, CD4 count, anti-HCV status and IFN-based therapies, the association with HDV retained statistical significance [HR = 1.67 (1.15, 2.95; p = 0.025)]. HDV infection among PLWH is underdiagnosed, although HDV entails an high risk of liver disease progression. Because effective drugs to treat HDV are now available, it is even more crucial to identify PLWH at an early stage of liver disease.

Published
2023
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93. Reducing overuse of antibiotics at discharge home: A single-center mixed methods pilot study.

Author

Giesler, Daniel L., Krein, Sarah, Brancaccio, Adamo, Mashrah, Daraoun, Ratz, David, Gandhi, Tejal, Bashaw, Linda, Horowitz, Jennifer, and Vaughn, Valerie

Abstract

• Antibiotic overuse at discharge is common and costly. • Antibiotic timeouts at discharge are feasible. • Pharmacists recommended antibiotic changes during 25% of timeouts, 70% were accepted. • Timeout barriers were unanticipated/weekend discharges and timeout interruptions. • Timeout facilitators were strong inter-disciplinary relationships. Antibiotic overuse at hospital discharge is common and harmful; however, methods to improve prescribing during care transitions have been understudied. We aimed to pilot a pharmacist-facilitated antibiotic timeout prior to discharge. From May 2019 to October 2019, we conducted a single-center, controlled pilot study of a pharmacist-facilitated antibiotic timeout prior to discharge. The timeout addressed key elements of stewardship (eg, duration) and was designed and implemented using iterative cycles with rapid feedback. We evaluated implementation outcomes related to feasibility, including usability, adherence, and acceptability, using mixed methods. Pre versus postintervention antibiotic use at discharge in intervention versus control groups was assessed using logistic regression models controlling for patient characteristics. Pharmacists conducted 288 antibiotic timeouts. Timeouts were feasible (mean 2.5 minutes per timeout) and acceptable (85% [40/48] of hospitalists believed timeouts improved prescribing). Pharmacists recommended an antibiotic change in 25% (73/288) of timeouts with 70% (51/73) of recommended changes accepted by hospitalists. Barriers to adherence included unanticipated and weekend discharges. Compared to control services, there were no differences in antibiotic use after discharge during the intervention. A pharmacist-facilitated antibiotic timeout at discharge was feasible and holds promise as a method to improve antibiotic use at discharge. [ABSTRACT FROM AUTHOR]

Published
2022
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96. Routine sterile glove and instrument change at the time of abdominal wound closure to prevent surgical site infection (ChEETAh): a pragmatic, cluster-randomised trial in seven low-income and middle-income countries

Author

Andoh, Aaron B, Atindaana Francis, Abantanga, Abdulkarim, Abdulhafiz A, Adesunkanmi, Abdulhafiz O, Salako, Abdulkadir A, Soladoye, Abdulmajeed, Sheshe, Abdulrahman A, Sani, Abdulrasheed, Lawal, Abdulrazzaq O, Lawal, Abdulwahab, Tripathi, Abhilasha, S, Abhishek, Akinloye, Abidemi, Olajumoke Balogun, Abigail, Ariyibi, Abimbola L, Okunlola, Abiodun I, Ojewuyi, Abiodun R, Oyedele, Abisola E, Sakyi, Abraham, Oladimeji, Abraham T, Bala Muhammad, Abubakar, Yahaya, Abubakar, Soibi-Harry, Adaiah P, Gyambibi, Addo K, Adeniyi, Adebayo A, Adeoluwa, Adebunmi, Olumide Osinowo, Adedapo, Salawu, Adedayo I, Fatuga, Adedeji L, Adesiyakan, Adedotun, Fakoya, Adegbolahan, Naah, Adeline, Adeyeye, Ademola A, Talabi, Ademola O, Fasanu, Adeniyi O, Ayoola Orowale, Adeola, Ojajuni, Adeolu, Adelaja, Aderinsola T, Ademuyiwa, Adesoji O, Jimoh, Adesola I, Aderounmu, Adewale A, Adisa, Adewale O, Ajagbe, Adewale O, Olajide, Adewale T, Bakare, Adewumi, Okunowo, Adeyemi A, Tchogo, Affisatou, Koledade, Afolabi K, Barthelemy Yevide, Agossou, Bello, Ahmad, Shehu Umar, Ahmad, Lawal, Ahmad T, Obiesie, Ahuizechukwu E, Dieudonne Hirwa, Aime, Domingo, Aimee, Mustapha, Aisha, Abdullahi, Aisha, Hada, Aissatou, Ijeoma, Aja, Adeleke, Akeem A, Adepiti, Akinfolarin C, Ajao, Akinlabi E, Sanusi, Akinsola T, Houndji, Albert, Bernal Hernández, Aldo, González Ojeda, Alejandro, Serrano García, Alejandro G, Ohemu, Alexander A, Arekhandia, Alexander I, Yakubu, Alfa, Hepzibah, Alice, Bhatt, Alisha, Muhammad Tukur, Aliyu, Ingabire, Allen JC, Okechukwu Ugwu, Aloy, Karekezi, Aloys, Maalekuu, Aloysius, Imanishimwe, Alphonsine, Bruce-Adjei, Amanda, Obbeng, Ambe, Akosua, Ameley, Jeffery-Felix, Ametepe, Mohammed-Durosinlorun, Amina A, Jimoh, Aminat O, Umar, Aminatu M, Umar, Aminu M, Mahajan, Amit, Eziyi, Amogu K, Bennin, Amos, Dasari, Amos, Okedare, Amos, Mathew, Amy E, Florencia Casado-Zarate, Ana, Calderón-Alvarado, Ana B, Dominguez, Ana Camille G, Cortés Flores, Ana O, Dusabimana, Anaclet, Kutma, Ananta, Byaruhanga, Anastase, Houndote, Anasthasie, Cueto Valadez, Andrea E, Alvarez Villaseñor, Andrea S, Bhangu, Aneel, Ortega Barreiro, Angelica, Mortola Lomeli, Angelo Fernando, Luther, Anil, Yahya, Anisah, Eseenam Agbeko, Anita, Thomas, Anita, Goyal, Ankush, Mkoh Dikao, Anne Stredy, Appiah, Anthony Baffour, Gaou, Antoine, Bediako-Bowan, Antoinette A, Ramos De la Medina, Antonio, Seidu, Anwar S, Munyaneza, Aphrodis, Ahounou, Aristide, Akoto-Ampaw, Arko, Hadonou, Armel, Alitonou, Arnaud, Sambo, Arouna, Mathew, Arpit J, Chaturvedi, Arun, Gautham, Arun K, Choudhrie, Ashish Victor, Attri, Ashok K, Kumar, Ashwani, Sukumar, Ashwin, Mehraj, Asif, Shittu, Asimiyu, Mukasine, Athanasie, Oppon-Acquah, Ato, Kusiwaa, Atta, Suroy, Atul, Ezenwa, Augusta O, Takure, Augustine O, Akinniyi, Ayodeji, Ogunyemi, Ayokunle A, Makanjuola, Ayomide, Dossou Yovo, B.T. Bonheur, Alhassan, Baba A B, Hamza, Babatunde K, Awoyinka, Babatunde S, Koomson, Barbara, Aminu, Bashiru, Abodunde Muideen, Bello, Osunwusi, Benedetto, García Reyna, Benjamín, Oppong, Benjamin A, Brimpong, Benjamin B, Fenu, Benjamin S, Ofori, Bernard A, Guzmán Ramírez, Bertha G, Nyadu, Bertina B, Shankar, Bharat, Lawal, Bilkisu K, Armstrong Alia, Bill, Roy, Bipradas, Kontor, Bismark E, Kovohouande, Blaise, Cakpo, Boniface, Enriquez Barajas, Brenda Vanessa, Crocco Quiros, Bruno, Kadir, Bryar, Mohammed, Caleb, Nwachukwu, Calistus U, Colunga Tinajero, Carlos, Ruiz Velasco, Carlos B, Zuloaga Fernández del Valle, Carlos J, Noufuentes, Carmen, Solomi, Carolin V, Okunlola, Cecilia K, Seneza, Celestin, Okafor, Celestine I, Nuño Escobar, Cesar, Banka, Charles, Barimah, Charles G, Chetana, Chetana, Nyatsambo, Chido, Okeke, Chike J, Jeffrey Ede, Chikwendu, Nwosu, Chimdiebele Daisy, Victoria Mgbemena, Chinelo, Onyeka, Chinonso U, Gold, Chinta S, Faith Uche, Chisom, Chigoze Makwe, Christian, Urimubabo, Christian Jean, Coompson, Christian L, Ashley-Osuzoka, Christiana, Gbenga-Oke, Christianah, Bidemi Oyegbola, Christianah, Mukakomite, Christine, Mpirimbanyi, Christophe, Asare, Christopher, Bode, Christopher O, Ugwunne, Chuka, Onyejiaka, Chukwudubem C, Okoro, Chukwuemeka, Okereke, Chukwuma E, Mukangabo, Clemence, Sie-Broni, Clement, Ballu, Cletus, Fuentes Orozco, Clotilde, Kyeremeh, Collins, Adumah, Collins C, Ruelas Bravo, Cornelio, Bokossa Kandokponou, Covalic Melic, Guerrero Ramírez, Cristhian S, Teye-Topey, Cynthia, Kpangon, Cyrille, Chinyio, Damai, Orozco Ramirez, Damaris, Mora Santana, Damián, Nyirasebura, Dancilla, Hérnandez Alva, Daniel A, Acquah, Daniel K, Prakash, Danita D, Sale, Danjuma, Olulana, Dare Isaac, Oruade, David, Jayne, David, Morales Iriarte, David Giovanny I, Ogudi, David K D, Olatola, David O, Akinboyewa, David O, Irabor, David O, Nuwam, Deborah, Mukantibaziyaremye, Deborah, Jain, Deepak, Singla, Deepak, Garnaik, Deepak K, Singh, Deepak S, Gakpetor, Delali A, Esssien, Derick, Rubanguka, Desire, Poonia, Dharma R, Ghosh, Dhruva, Ahogni, Didier, Morton, Dion, Umuhoza, Divine, Morel Seto, Djifid, Nepogodiev, Dmitri, Enti, Donald, Smith, Donna, Osei-Poku, Dorcas, Acheampong, Dorcas O, Mellado, Dorihela H, Ofosuhene, Doris, Cortes Torres, Edgar J, Efren Lozada, Edgard, Gómez Sánchez, Eduardo, González Espinoza, Eduardo, Osei, Edwin, Mensah, Elijah, Rwagahirima, Elisee, Quartson, Elizabert M, Li, Elizabeth, Kurien, Elizabeth N, Bonilla Ahumada, Elyoenai, Kabanda, Elysee, Odame, Emelia, Izabiriza, Emelyne, Hatangimana, Emery, Osariemen, Emili, Reyes Elizalde, Emilio A, Agbowada, Emma A, Usam, Emmanuel, Sylvester Inyang, Emmanuel, Owie, Emmanuel, Ojo Williams, Emmanuel, Munyaneza, Emmanuel, Mutabazi, Emmanuel, Kojo Acquah, Emmanuel, Obiri, Emmanuel L, Ofori, Emmanuel O, Runigamugabo, Emmy, Yhoshu, Enono, Malade, Enrif, Cervantes Perez, Enrique, Kobby, Ephraim, Okwudiri Ohazurike, Ephraim, Jerry Bara, Eric, Agyemang, Eric, Akoto, Erica, Villanueva-Martínez, Erick E, Mwungura, Espoir, Cueva Martinez, Esteban, Asabre, Esther, Adjei-Acquah, Esther, Abunimye, Esther, Daluk, Esther B, Daniel, Esther R, Ike Okorie, Ethos, Ailunia, Eunice E, Abraham, Eunice S, Romo Ascencio, Evelia V, Harrison, Ewen, Kpatchassou, Expedit, Bakari, Fadimatu, González Ponce, Fanny Y, Huda, Farhanul, Abubakari, Fatao, Ntirenganya, Faustin, Ingabire, Faustine, Parray, Fazl Q, Brant, Felicity, Alakaloko, Felix M, Diaz Samano, Fernanda, Duque Zepeda, Fernando, Bello-Tukur, Firdaws, Basirwa Musengo, Fiston, Dedey, Florence, Adegoke, Folasade, Amponsah-Manu, Forster, Mukaneza, Francine, Chinonso Ezenwankwo, Francis, Sanwo, Francis, Dossou, Francis Moise, Nwaenyi, Francisca C, Ibanez Ortiz, Francisco, Barbosa Camacho, Francisco J, León-Frutos, Francisco J, Plascencia Posada, Francisco J, Nirere, Francoise, Owusu, Frank, Gyamfi, Frank E, Wuraola, Funmilola O, Cervantes Guevara, Gabino, Ntwari, Gabriel, Ambriz-González, Gabriela, Hyman, Gabriella, Umar, Garzali I, Thami, Gaurav, Adeleye, Gbadebo T C, Limann, Gbana, Ajibola, Gboyega, Ida, Genesis, Ihediwa, George C, Brown, George D, Bucyibaruta, Georges, Gallardo Banuelos, Gerardo, Lopez Arroyo, Gerardo, Ndegamiye, Gibert, Naah, Gifty, Morgan Villela, Gilberto, Edet, Glory, Attepor, Godsway S, Akaba, Godwin O, Aziz, Gowhar, Yeboah, Grace, Mary, Grace, Eke, Grace, Castillo Cardiel, Guadalupe, Yanowsky Reyes, Guillermo, Sanchez Villaseñor, Guillermo, Cervantes Cardona, Guillermo A, Singh, Gurtaj, Boateng, Guy C, Kola, H.Pauline, Abdullahi, Habiba I, Olaide Raji, Hadijat, Ahmed, Hafsa I, Umaru-Sule, Hajara, Kaur, Harmanjot, Malechi, Hawa, Sunday, Helen, Abiyere, Henry O, Butana, Herbert, Agossou, Hermann, Samkelisiwe Nxumalo, Hlengiwe, Maniraguha, Hope Lydia, Dewamon, Hubert, Yome, Hugues, Behanzin, Hulrich, Ekwuazi, Hyginus O, Oweredaba, Ibiene T, Mohammed, Ibrahim, Sufyan, Ibrahim, Saidu, Ibrahim A, Abdul-Aziz, Iddrisu I A, Eseile, Ideyonbe Samuel, Ogolekwu, Idoko P, Adebara, Idowu O, Usman Takai, Idris, Fidelis Okafor, Ifeanyi, Kene, Ifeanyi A, Enyinnaya Iweha, Ikechukwu, Mutimamwiza, Immaculee, Mantoo, Imtiyaz, Duruewuru, Innocent O, Akpo, Irene, Niyongombwa, Irenee, Brancaccio Pérez, Irma V, Esparza Estrada, Isaac, Gundu, Isaac, Morkor Opandoh, Isabella N, Ncogoza, Isaie, Sibomana, Isaie, Bansal, Ishan, Cabrera-Lozano, Ishtar, Ishola Aremu, Isiaka, Gandaho, Isidore, Lawani, Ismail, Ochoa Rodríguez, Itzel, Alasi, Iyabo O, Alhassan, Jaabir, Mends-Odro, Jacqueline, Osuna Rubio, Jacqueline, Orozco Perez, Jaime, González Bojorquez, Jaime L, Rodriguez Ramirez, Jairo Arturo, Glasbey, James, Emeka, James J, Lawal, Jamila, Acquaye, Jane, Alfred, Janet, Rugendabanga, Janvier, Mizero, Japhet, Ingabire, JC Allen, Aimable Habiyakare, Jean, Claude Uwimana, Jean, de Dieu Haragirimana, Jean, Yves Shyirakera, Jean, Utumatwishima, Jean N, Niyomuremyi, Jean Paul, Majyabere, Jean Paul, Masengesho, Jean Pierre, Nyirahabimana, Jeannette, Vishnoi, Jeevan R, Kalyanapu, Jeffery A, Joseph, Jeremiah N, Makama, Jerry G, Pizarro Lozano, Jesus, Aguilar Mata, Jesus Antonion, Morales, Jesus Flavio M, Vega Gastelum, Jesus O, Oyekunle Bello, Jibril, Okechukwu Ugwu, Jideofor, Amoako, Joachim K, Simoes, Joana, Zirikana, Job, Nzuwa Nsilu, Joel, Adze, Joel A, Enaholo, Joel E, Obateru, John A, Chinda, John Y, Akunyam, Johnson, Boakye-Yiadom, Jonathan, Cook, Jonathan, Quansah, Jonathan I K, Chejfec Ciociano, Jonathan M, Jiménez Tornero, Jorge, Herrera-Esquivel, Jose, Flores Cardoza, Jose A, Sánchez Martínez, José A, Guzmán Barba, José A, Pesquera, Jose Alberto A, Orozco Navarro, Jose Esteban, Sandoval Pulido, José I, Pérez Navarro, Jose V, Igiraneza, Joselyne, Ejimogu, Joseph, Awindaogo, Joseph K, Ugboajah, Joseph O, Ashong, Josephine, Nsaful, Josephine, Arthur, Joshua, Yakubu, Josiah, Mutuyimana, Josiane, Umuhoza, Josine, Thomas, Josy, Ibarrola Peña, Juan C, Tijerina Ávila, Juan J, Oladayo Kuku, Jubril, Gyamfi, Jude E, Brown, Julia, Appiah, Juliana, Attinon, Julien, Jacob, Jurgen, Gimba, Justina, Seyi-Olajide, Justina O, Ngaguene, Juvenal, Jyoti, Jyoti, Leshiini, K, Boukari, K. Alassan, Kumar, Karan, Mumuni, Kareem, Quarchey, Karen N D, Sanni, Katia, Bozada-Gutierrez, Katya, Mandrelle, Kavita, Atobatele, Kazeem M, Awodele, Kehinde, Bawa, Kehinde G, Duromola, Kehinde Michael, Egbuchulem, Kelvin I, Ngaaso, Kennedy, Onyekachi, Kenneth, Ugwuanyi, Kenneth, Okoduwa, Kester O, Ado, Khadija A, Rathod, Kirti K, Nunoo-Ghartey, Kojo, Rautela, Komal, Kennedy, Korankye K, Ascencio Díaz, Kriscia V, Boakye-Yiadom, Kwaku, Onahi Iji, Lambert, Magill, Laura, Martinez Perez Maldonado, Laura, Pena Baolboa, Laura Gabriela, Montano Angeles, Laura Olivia, Barau Abdullahi, Lawal, Ismail, Lawani, Awere-Kyere, Lawrence K B, Uzikwambara, Leoncie, Adam-Zakariah, Leslie, Larbi-Siaw, Linda A, Chukwuemeka Anyanwu, Lofty-John, Etchisse, Lolyta, Abdulrasheed, Lubabatu, Agbanda, Lucien, García González, Luis A, Suárez Carreón, Luis O, Cifuentes Andrade, Luis R, Pacheco Vallejo, Luis R, Ramirez Gonzalez, Luis R, Aniakwo, Luke A, Olajide Abdur-Rahman, Lukman, Abdur-Rahman, Lukman Olajide, Namur, Luz del Carmen M, Mukamazera, Lydia, Airede, Lydia R, Nontonwanou, M.J. Bienvenue, Amoako-Boateng, Mabel P, Rodha, Mahaveer S, Kawu Magashi, Mahmoud, Abubakar, Maimuna, Yigah, Makafui, Dayie, Makafui S C J K, Victorin Agbangla, Mamonde, Pathak, Manish, Aggarwal, Manisha, Lokavarapu, Manoj J, Talla Timo, Manuella, Isikhuemen, Maradona E, Gbassi, Marcel, Uwizeye, Marcel, Akpla, Marcelin, Adjei, Margarey N M, Picciochi, Maria, Chávez, Maria, Fourtounas, Maria, Quirarte Hernández, María A, Zarate Casas, Maria F, Gloriose Nabada, Marie, Kouroumta, Marie-Claire, De Cristo Gonzalez Calvillo, Marijose, Trejo-Avila, Mario, Guzmán Ruvalcaba, Mario J, Monahan, Mark, Jesudason, Mark R, Zume, Marshall, Totin, Martin, Djeto, Martin, Awe, Martin, Islas Torres, Martin, Morna, Martin T, Oluwadamilola Adebisi, Mary, Adams, Mary Augusta, Oluwatobi Busari, Maryam, Lazo Ramirez, Maryzela, Taingson, Mathew C, Ruhosha, Mathias, Dery, Mathias K, Batangana, Mediatrice, Mellado Tellez, Mel P, Vicencio Ramirez, Melissa L, Agyapong, Meshach M, Nortey, Michael, Amao, Michael, Bahrami-Hessari, Michael, Calderón Llamas, Miguel A, Calderon Vanegas, Miguel Antonio, Azanlerigu, Millicent, Becerra Moscoso, Mitzi R, Sethoana, Mmule Evelyn, Oludara, Mobolaji A, Moussa Alidou, Mohamed, Mohammad, Mohammad A, Bashir, Mohammed, Usman, Mohammed, Adnan, Mohammed, Alhassan, Mohammed S, Aliyu, Mohammed S, Singh, Mohit, Muhindo, Moise, Dusabeyezu, Moise, Kichu, Moloti, Castillo, Monica N, Gureh, Monika, Hans, Monika A, Hollo, Monsede, Hodonou, Montcho Adrien, Sivakumar, Moonish V, Edena, Morrison E, Abdulsalam, Moruf A, Adebisi Ogunjimi, Moses, Dusabe, Moses, Dokurugu, Moses A, Galadima, Moses C, Agbulu, Moses Vincent, Agbadebo, Mouhamed, Eunice, Moyosoluwa Eunice, Nosipho Mathe, Mpho, Moreno-Portillo, Mucio, Awaisu, Mudi, Daniyan, Muhammad, Duke George, Mukoro, Malik, Muneer A, Amadu, Munira, Pai, Murlidhar V, Adetola Tolani, Musliu, Abdullahi, Muzzammil, Moussa, Nabil, Guessou, Nafissatou Orou, Saqib, Najmus, Christian, Nana Ama, Essel, Nanabanyin, Tabuanu, Nancy O, Olagunju, Naomi, Sam, Napoleon Bellua, Akhtar, Naseem, Oyelowo, Nasir, Bisimwa Mitima, Nathan, Adewole, Nathaniel D, Sharma, Naveen, Anthea Nhlabathi, Ncamsile, Mbajiekwe, Ndubuisi, Mishra, Neha, Pundir, Neha, Winkles, Neil, Smart, Neil, Agboadoh, Nelson, Ndukwe, Ngozi O, Aperkor, Nicholas T, Adu-Aryee, Nii A, Chowdri, Nisar A, Singh, Nishu, Peters, Nitin J, Sharma, Nivedita, Agrawal, Nivesh, Syam, Niyah, Duru, Nnamdi Jonathan, Sentholang, Nnosa, Okoi, Nnyonno, Anyanwu, Noble, Rene Hounsou, Nounagnon, Aliyu, Nura U, Abiola Adeleke, Nurudeen, Egwuonwu, Ochonma A, Okoye, Odili A, Hyginus Ekwunife, Okechukwu, Olanrewaju, Olabisi, Osagie, Olabisi O, Adeyemo, Olabisi T, Oshodi, Olabode A, Olaolu Ogundoyin, Olakayode, Ogundoyin, Olakayode O, Babalola, Olakunle F, Olasehinde, Olalekan, Ajai, Olalekan T, Balogun, Olanrewaju S, Lawal, Olatunji O, Olayioye, Olawunmi, Sayomi, Olayinka, Samuel, Oliver, Mwenedata, Olivier, Oluwaseyi Bakare, Oludayo, Sowande, Oludayo A, Ojewuyi, Olufemi O, Omisanjo, 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Koggoh, Patience, Igwe, Patrick O, Trinity, Paul, Aderemi Adegoke, Paul, Wondoh, Paul, Domínguez Barradas, Paulina, Ogouyemi, Pencome, Boakye, Percy, Brocklehurst, Peter, Elemile, Peter, Egharevba, Peter A, Agbonrofo, Peter I, Okoro, Philemon E, Kumassah, Philemon K, Mensah, Philip, Munda, Philip, Mshelbwala, Philip M, Alexander, Philip V, Nyirangeri, Pierrine, Muroruhirwe, Piolette, Hardy, Pollyanna, Kwabena, Ponala W, Zechariah, Pradeep, Nayak, Pragyanmai, Dummala, Prashant, Singh, Prashant, Solanki, Pratik, Yeboah Owusu, Prince, Mary, Priya, Chowdhury, Priyanka, Luri, Prosper T, Pareek, Puneet, Prakash, Puneet, Kumari, Pushplatha, Lillywhite, Rachel, Moore, Rachel, Tinuola Afolabi, Rafiat, Williams, Rahul, Alpheus, Rahul A, Sharma, Rajeev, Seenivasagam, Rajkumar K, Vakil, Rakesh, Armah, Ralph, Samujh, Ram, Chaudhary, Ramkaran, John, Raphael E, Gunny, Rashmi Jacob, Wani, Rauf A, Verma, Raunak, Thind, Ravinder Singh, Dar, Rayees A, Eghonghon, Raymond A, Acquah, Regina, Rajappa, 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Abstract

Surgical site infection (SSI) remains the most common complication of surgery around the world. WHO does not make recommendations for changing gloves and instruments before wound closure owing to a lack of evidence. This study aimed to test whether a routine change of gloves and instruments before wound closure reduced abdominal SSI.

Published
2022
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98. Liner dissociation in total hip arthroplasty: a systematic review.

Author

CIOLLI, G., SILVA, R., GIOVANNETTI DE SANCTIS, E., PROIETTI, L., MOCINI, F., CORONA, K., MAZZOLENI, M. G., ROMANINI, E., MARESCALCHI, M., BRANCACCIO, V., MACCAURO, G., and CERCIELLO, S.

Abstract

OBJECTIVE: Liner dissociation (LD) is a rare catastrophic mechanical failure of total hip arthroplasty (THA). The study aims at reviewing the available literature regarding liner dissociations to point out their prevalence, describing any possible association and highlighting the surgical management at the time of revision. MATERIALS AND METHODS: A systematic review of the literature was conducted from January 2002, until February 2022, according to the PRISMA guidelines. The main keywords were: "dissociation" AND "liner" OR "hip arthroplasty" OR "THA" and their MeSH terms in any possible combination. Cases of liner dissociation with all levels of evidence of any age published in indexed journals were included. The study quality of all included studies was evaluated using the MINORS criteria. The kappa (k) value was used to assess the consensus between reviewers in the selection of articles and methodological quality assessment. Finally, a sub-analysis was performed specifically concerning the elderly population. RESULTS: Thirty-one manuscripts met the inclusion criteria of the systematic review (21 case reports and 10 case series). 124 LD in 123 patients, (53% females and 47% males) were evaluated. The overall prevalence of LD was 0.15%. The mean age at surgery was of 56.5 years (range 31-75 years). LD occurred in a primary surgery setting in 86% of the cases, at a mean time of presentation of 45.8 months after replacement surgery. 39.5% of the cups and 8.8% of the stems required revision. The mean follow-up after the revision was 18.4 months. Complications after revision occurred in 19.6% of cases, including 3 cases of re-dissociations. Re-revision was required in 13.6% of the revisions. The sub-analysis of the elderly population included 28 cases of LD identified in 10 manuscripts, with an average age of 73.5 years. CONCLUSIONS: LD is a rare but catastrophic mechanical complication of modular THA that requires implant revision. The LD is not related to a specific prosthetic implant, liner material or design, acetabular positioning within the safe zone or age group. [ABSTRACT FROM AUTHOR]

Published
2022

99. Measurement of electroweak parameters fromZ decays into fermion pairs

Author

Decamp, D., Deschizeaux, B., Goy, C., Lees, J. -P., Minard, M. -N., Alemany, R., Crespo, J. M., Delfino, M., Fernandez, E., Gaitan, V., Garrido, Ll., Mato, P., Miquel, R., Mir, Ll. M., Orteu, S., Pacheco, A., Perlas, J. A., Tubau, E., Catanesi, M. G., Creanza, D., de Palma, M., Farilla, A., Iaselli, G., Maggi, G., Maggi, M., Natali, S., Nuzzo, S., Quattromini, M., Ranieri, A., Raso, G., Romano, F., Ruggieri, F., Selvaggi, G., Silvestris, L., Tempesta, P., Zito, G., Gao, Y., Hu, H., Huang, D., Jin, S., Lin, J., Ruan, T., Wang, T., Wu, W., Xie, Y., Xu, D., Xu, R., Zhang, J., Zhao, W., Albrecht, H., Atwood, W. B., Bird, F., Blucher, E., Bonvicini, G., Bossi, F., Bourotte, J., Brown, D., Burnett, T. H., Drevermann, H., Dydak, F., Forty, R. W., Grab, C., Hagelberg, R., Haywood, S., Jost, B., Kasemann, M., Kellner, G., Knobloch, J., Lacourt, A., Lehraus, I., Lohse, T., Lüke, D., Marchioro, A., Martinez, M., May, J., Menary, S., Minten, A., Miotto, A., Nash, J., Palazzi, P., Ranjard, F., Redlinger, G., Roth, A., Rothberg, J., Rotscheidt, H., von Rüden, W., Denis, R. St., Schlatter, D., Takashima, M., Talby, M., Taureg, H., Tejessy, W., Wachsmuth, H., Wasserbaech, S., Wheeler, S., Wiedenmann, W., Witzeling, W., Wotschack, J., Ajaltouni, Z., Bardadin-Otwinowska, M., Falvard, A., Fellous, R. El, Gay, P., Henrard, P., Jousset, J., Michel, B., Montret, J-C., Pallin, D., Perret, P., Proriol, J., Prulhière, F., Hansen, J. D., Hansen, J. R., Hansen, P. H., Møllerud, R., Nilsson, B. S., Petersen, G., Efthymiopoulos, I., Simopoulou, E., Vayaki, A., Badier, J., Blondel, A., Bonneaud, G., Braems, F., Brient, J. C., Fouque, G., Gamess, A., Guirlet, R., Rosowsky, A., Rougé, A., Rumpf, M., Tanaka, R., Videau, H., Videau, I., Candlin, D. J., Parrini, G., Corden, M., Georgiopoulos, C., Ikeda, M., Lannutti, J., Levinthal, D., Mermikides, M., Sawyer, L., Stimpfl, G., Antonelli, A., Baldini, R., Bencivenni, G., Bologna, G., Campana, P., Capon, G., Chiarella, V., D'Ettorre-Piazzoli, B., Felici, G., Laurelli, P., Mannocchi, G., Massimo Brancaccio, F., Murtas, F., Murtas, G. P., Nicoletti, G., Pepe-Altarelli, M., Picchi, P., Zografou, P., Altoon, B., Boyle, O., Halley, A. W., ten Have, I., Hearns, J. L., Lynch, J. G., Morton, W. T., Raine, C., Scarr, J. M., Smith, K., Thompson, A. S., Brandl, B., Braun, O., Geiges, R., Geweniger, C., Hanke, P., Hepp, V., Kluge, E. E., Maumary, Y., Panter, M., Putzer, A., Rensch, B., Stahl, A., Tittel, K., Wunsch, M., Belk, A. T., Beuselinck, R., Binnie, D. M., Cameron, W., Cattaneo, M., Dornan, P. J., Dugeay, S., Greene, A. M., Hassard, J. F., Patton, S. J., Sedgbeer, J. K., Taylor, G., Tomalin, I. R., Wright, A. G., Girtler, P., Kneringer, E., Kuhn, D., Rudolph, G., Bowdery, C. K., Brodbeck, T. J., Finch, A. J., Foster, F., Hughes, G., Keemer, N. R., Nuttall, M., Rowlingson, B. S., Sloan, T., Snow, S. W., Barczewski, T., Bauerdick, L. A. T., Kleinknecht, K., Renk, B., Roehn, S., Sander, H. G., Schmelling, M., Steeg, F., Albanese, J-P., Aubert, J-J., Benchouk, C., Bernard, V., Bonissent, A., Courvoisier, D., Etienne, F., Papalexiou, S., Payre, P., Puietrzyk, B., Qian, Z., Blum, W., Cattaneo, P., Cowan, G., Dehning, B., Dietl, H., Fernandez-Bosman, M., Frank, M., Jahn, A., Lange, E., Lütjens, G., Lutz, G., Männer, W., Moser, H-G., Pan, Y., Richter, R., Schwarz, A. S., Settles, R., Stiegler, U., Stierlin, U., Thomas, J., Bertin, V., de Bouard, G., Boucrot, J., Callot, O., Chen, X., Cordier, A., Davier, M., Ganis, G., Grivaz, J. -F., Heusse, Ph., Janot, P., Journé, V., Kim, D. W., Lefrançois, J., Lutz, A. M., Veillet, J. -J., Zhang, Z., Zomer, F., Amendolia, S. R., Bagliesi, G., Batignani, G., Bosisio, L., Bottigli, U., Bradaschia, C., Ciocci, M. A., Ferrante, I., Fidecaro, F., Foà, L., Focardi, E., Forti, F., Giassi, A., Giorgi, M. A., Ligabue, F., Lusiani, A., Mannelli, E. B., Marrocchesi, P. S., Messineo, A., Palla, F., Sanguinetti, G., Steinberger, J., Tenchini, R., Tonelli, G., Triggiani, G., Carter, J. M., Green, M. G., March, P. V., Medcalf, T., Saich, M. R., Strong, J. A., Thomas, R. M., Wildish, T., Botterill, D. R., Clifft, R. W., Edgecock, T. R., Edwards, M., Fisher, S. M., Harvey, J., Jones, T. J., Norton, P. R., Salmon, D. P., Thompson, J. C., Bloch-Devaux, B., Colas, P., Klopfenstein, C., Lançon, E., Locci, E., Loucatos, S., Mirabito, L., Monnier, E., Perez, P., Perrier, F., Rander, J., Renardy, J. -F., Roussarie, A., Schuller, J. -P., Ashman, J. G., Booth, C. N., Combley, F., Dinsdale, M., Martin, J., Parker, D., Thompson, L. F., Brandt, S., Burkhardt, H., Grupen, C., Meinhard, H., Neugebauer, E., Schäfer, U., Seywerd, H., Apollinari, G., Giannini, G., Gobbo, B., Liello, F., Milotti, E., Rolandi, L., Bellantoni, L., Boudreau, J. F., Cinabro, D., Conway, J. S., Cowen, D. F., DeWeerd, A. J., Feng, Z., Ferguson, D. P. S., Gao, Y. S., Harton, J. L., Hilgart, J., Jacobsen, J. E., Jared, R. C., Johnson, R. P., LeClaire, B. W., Pan, Y. B., Parker, T., Pater, J. R., Saadi, Y., Sharma, V., Wear, J. A., Weber, F. V., Lan Wu, Sau, Zobernig, G., and ALEPH Collaboration

Published
1990
Full Text
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100. MASS-SAT: Matter-Antimatter Space Spectrometer on Satellite

Author

Basini, G., Candusso, M., Massimo Brancaccio, F., Ricci, M., Bocciolini, M., Spillantini, P., Wang, Yi. -F., Bongiorno, F., De Pascale, M. P., Morselli, A., Picozza, P., De Marzo, C., Erriquez, O., Barbiellini, G., Vacchi, A., Galeotti, P., Ballocchi, G., Simon, M., Carlson, P., Goret, P., and Golden, R. L.

Published
1990
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