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Erythrocytes of the horse and some other species treated with mallein were rendered thereby agglutinable by high dilutions of anti-mallein sera and by the serum of a human patient suffering from infectious melidioidosis. Erythrocytes of ox and pig could not be sensitized to agglutination under the same conditions. The sensitization by mallein of horse red cells to agglutination by antimallein sera was inhibited by an alcohol-ether extract of these cells.

Comments on the significance of biohistorical paradigm in the development of a society and the achievement of ecological sustainability. Background on cultural maladaptations; Information on cultural reform movements employed in response to ecological sustainability; Role of ecological unsustainability in changing a society.